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502 results on '"Noma, Kazuhiro"'

51. Supplementary Figure S2: Transduction efficiency by Ad/HER2-ECD in organs and peritoneally disseminated tumor from Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

Author

Ishida, Michihiro, primary, Kagawa, Shunsuke, primary, Shimoyama, Kyoko, primary, Takehara, Kiyoto, primary, Noma, Kazuhiro, primary, Tanabe, Shunsuke, primary, Shirakawa, Yasuhiro, primary, Tazawa, Hiroshi, primary, Kobayashi, Hisataka, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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53. Supplementary Figure S3: The characteristics of SKOV-3/Luc cells from Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

Author

Ishida, Michihiro, primary, Kagawa, Shunsuke, primary, Shimoyama, Kyoko, primary, Takehara, Kiyoto, primary, Noma, Kazuhiro, primary, Tanabe, Shunsuke, primary, Shirakawa, Yasuhiro, primary, Tazawa, Hiroshi, primary, Kobayashi, Hisataka, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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54. Morphological changes induced immediately after Tra-IR700-mediated PIT from Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

Author

Ishida, Michihiro, primary, Kagawa, Shunsuke, primary, Shimoyama, Kyoko, primary, Takehara, Kiyoto, primary, Noma, Kazuhiro, primary, Tanabe, Shunsuke, primary, Shirakawa, Yasuhiro, primary, Tazawa, Hiroshi, primary, Kobayashi, Hisataka, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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60. Supplementary Table S1 from Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor

Author

Sakurama, Kazufumi, primary, Noma, Kazuhiro, primary, Takaoka, Munenori, primary, Tomono, Yasuko, primary, Watanabe, Nobuyuki, primary, Hatakeyama, Shinji, primary, Ohmori, Osamu, primary, Hirota, Seiichi, primary, Motoki, Takayuki, primary, Shirakawa, Yasuhiro, primary, Yamatsuji, Tomoki, primary, Haisa, Minoru, primary, Matsuoka, Junji, primary, Tanaka, Noriaki, primary, and Naomoto, Yoshio, primary

Published
2023
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61. Data from Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor

Author

Sakurama, Kazufumi, primary, Noma, Kazuhiro, primary, Takaoka, Munenori, primary, Tomono, Yasuko, primary, Watanabe, Nobuyuki, primary, Hatakeyama, Shinji, primary, Ohmori, Osamu, primary, Hirota, Seiichi, primary, Motoki, Takayuki, primary, Shirakawa, Yasuhiro, primary, Yamatsuji, Tomoki, primary, Haisa, Minoru, primary, Matsuoka, Junji, primary, Tanaka, Noriaki, primary, and Naomoto, Yoshio, primary

Published
2023
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62. Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7, Table S1, Table S2, Table S3, Table S4 from Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment

Author

Kato, Takuya, primary, Noma, Kazuhiro, primary, Ohara, Toshiaki, primary, Kashima, Hajime, primary, Katsura, Yuki, primary, Sato, Hiroaki, primary, Komoto, Satoshi, primary, Katsube, Ryoichi, primary, Ninomiya, Takayuki, primary, Tazawa, Hiroshi, primary, Shirakawa, Yasuhiro, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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63. Data from Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery

Author

Kuroda, Shinji, primary, Fujiwara, Toshiya, primary, Shirakawa, Yasuhiro, primary, Yamasaki, Yasumoto, primary, Yano, Shuya, primary, Uno, Futoshi, primary, Tazawa, Hiroshi, primary, Hashimoto, Yuuri, primary, Watanabe, Yuichi, primary, Noma, Kazuhiro, primary, Urata, Yasuo, primary, Kagawa, Shunsuke, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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64. Supplementary Methods, Figures 1-10 from Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery

Author

Kuroda, Shinji, primary, Fujiwara, Toshiya, primary, Shirakawa, Yasuhiro, primary, Yamasaki, Yasumoto, primary, Yano, Shuya, primary, Uno, Futoshi, primary, Tazawa, Hiroshi, primary, Hashimoto, Yuuri, primary, Watanabe, Yuichi, primary, Noma, Kazuhiro, primary, Urata, Yasuo, primary, Kagawa, Shunsuke, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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72. RNA Editing is a Valuable Biomarker for Predicting Carcinogenesis in Ulcerative Colitis

Author

Takahashi, Kazutaka, primary, Shigeyasu, Kunitoshi, additional, Kondo, Yoshitaka, additional, Gotoh, Kazuyoshi, additional, Yano, Shuya, additional, Umeda, Yuzo, additional, Inokuchi, Toshihiro, additional, Xu, Caiming, additional, Yoshida, Kazuhiro, additional, Umeda, Hibiki, additional, Takahashi, Toshiaki, additional, Takeda, Sho, additional, Yoshida, Ryuichi, additional, Teraishi, Fuminori, additional, Kishimoto, Hiroyuki, additional, Mori, Yoshiko, additional, Noma, Kazuhiro, additional, Okugawa, Yoshinaga, additional, Hiraoka, Sakiko, additional, Michiue, Hiroyuki, additional, Tazawa, Hiroshi, additional, Matsushita, Osamu, additional, Goel, Ajay, additional, and Fujiwara, Toshiyoshi, additional

Published
2022
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73. ASO Visual Abstract: Effect of Patient-Participation Continuous Nutritional Counseling in Gastric Cancer Patients Who Underwent Gastrectomy

Author

Takata, Nobuo, primary, Kikuchi, Satoru, additional, Kuroda, Shinji, additional, Tanabe, Shunsuke, additional, Maeda, Naoaki, additional, Noma, Kazuhiro, additional, Takahashi, Ayako, additional, Umeda, Yuzo, additional, Shikata, Kenichi, additional, Ozaki, Kazuhide, additional, and Fujiwara, Toshiyoshi, additional

Published
2022
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80. Dual-Targeted Near-Infrared Photoimmunotherapy for Esophageal Cancer and Cancer-Associated Fibroblasts in the Tumor Microenvironment

Author

Sato, Hiroaki, primary, Noma, Kazuhiro, additional, Ohara, Toshiaki, additional, Kawasaki, Kento, additional, Akai, Masaaki, additional, Kobayashi, Teruki, additional, Nishiwaki, Noriyuki, additional, Narusaka, Toru, additional, Komoto, Satoshi, additional, Kashima, Hajime, additional, Katsura, Yuki, additional, Kato, Takuya, additional, Kikuchi, Satoru, additional, Tazawa, Hiroshi, additional, Kagawa, Shunsuke, additional, Shirakawa, Yasuhiro, additional, Kobayashi, Hisataka, additional, and Fujiwara, Toshiyoshi, additional

Published
2022
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81. Impact of Amino Acids Nutrition Following Gastrectomy in Gastric Cancer Patients

Author

KIKUCHI, SATORU, primary, TAKATA, NOBUO, additional, KURODA, SHINJI, additional, UMEDA, HIBIKI, additional, TANABE, SHUNSUKE, additional, MAEDA, NAOAKI, additional, TAKAGI, KOSEI, additional, NOMA, KAZUHIRO, additional, HASEGAWA, YUKO, additional, NAWACHI, KUMIKO, additional, KAGAWA, SHUNSUKE, additional, UMEDA, YUZO, additional, SHIKATA, KENICHI, additional, and FUJIWARA, TOSHIYOSHI, additional

Published
2022
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82. RNA Editing is a Valuable Biomarker for Predicting Carcinogenesis in Ulcerative Colitis.

Author

Takahashi, Kazutaka, Shigeyasu, Kunitoshi, Kondo, Yoshitaka, Gotoh, Kazuyoshi, Yano, Shuya, Umeda, Yuzo, Inokuchi, Toshihiro, Xu, Caiming, Yoshida, Kazuhiro, Umeda, Hibiki, Takahashi, Toshiaki, Takeda, Sho, Yoshida, Ryuichi, Teraishi, Fuminori, Kishimoto, Hiroyuki, Mori, Yoshiko, Noma, Kazuhiro, Okugawa, Yoshinaga, Hiraoka, Sakiko, and Michiue, Hiroyuki

Abstract

Background and Aims Ulcerative colitis [UC] can lead to colitis-associated colorectal neoplasm [CAN]. Adenosine-to-inosine RNA editing, which is regulated by adenosine deaminase acting on RNA [ADAR], induces the post-transcriptional modification of critical oncogenes, including antizyme inhibitor 1 [AZIN1], leading to colorectal carcinogenesis. Therefore, we hypothesized that ADAR1 might be involved in the development of CAN in UC. Methods We systematically analysed a cohort of 139 UC cases [40 acute phase, 73 remission phase, 26 CAN]. The degree of inflammation was evaluated using the Mayo endoscopic score [MES]. Results The type 1 interferon [IFN]-related inflammation pathway was upregulated in the rectum of active UC, rectum of UC-CAN and tumour site of UC-CAN patients. ADAR1 expression was upregulated in the entire colon of CAN cases, while it was downregulated in non-CAN MES0 cases. ADAR1 expression in the rectum predicted the development of CAN better than p53 or β-catenin, with an area under the curve of 0.93. The high expression of ADAR1 and high AZIN1 RNA editing in UC was triggered by type 1 IFN stimulation from UC-specific microbiomes, such as seen in Fusobacterium in vitro analyses. The induction of AZIN1 RNA editing by ADAR1, whose expression is promoted by Fusobacterium , may induce carcinogenesis in UC. Conclusions The risk of CAN can be evaluated by assessing ADAR1 expression in the rectum of MES0 UC patients, freeing UC patients from unnecessary colonoscopy and reducing their physical burden. RNA editing may be involved in UC carcinogenesis, and may be used to facilitate the prevention and treatment of CAN in UC. [ABSTRACT FROM AUTHOR]

Published
2023
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88. Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments

Author

Shirakawa, Yasuhiro, primary, Tazawa, Hiroshi, additional, Tanabe, Shunsuke, additional, Kanaya, Nobuhiko, additional, Noma, Kazuhiro, additional, Koujima, Takeshi, additional, Kashima, Hajime, additional, Kato, Takuya, additional, Kuroda, Shinji, additional, Kikuchi, Satoru, additional, Kagawa, Shunsuke, additional, Katsui, Kuniaki, additional, Kanazawa, Susumu, additional, Urata, Yasuo, additional, and Fujiwara, Toshiyoshi, additional

Published
2021
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90. Nanog is a promising chemoresistant stemness marker and therapeutic target by iron chelators for esophageal cancer

Author

Narusaka, Toru, primary, Ohara, Toshiaki, additional, Noma, Kazuhiro, additional, Nishiwaki, Noriyuki, additional, Katsura, Yuki, additional, Kato, Takuya, additional, Sato, Hiroaki, additional, Tomono, Yasuko, additional, Kikuchi, Satoru, additional, Tazawa, Hiroshi, additional, Shirakawa, Yasuhiro, additional, Matsukawa, Akihiro, additional, and Fujiwara, Toshiyoshi, additional

Published
2021
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91. Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis

Author

Kajioka, Hiroki, primary, Kagawa, Shunsuke, additional, Ito, Atene, additional, Yoshimoto, Masashi, additional, Sakamoto, Shuichi, additional, Kikuchi, Satoru, additional, Kuroda, Shinji, additional, Yoshida, Ryuichi, additional, Umeda, Yuzo, additional, Noma, Kazuhiro, additional, Tazawa, Hiroshi, additional, and Fujiwara, Toshiyoshi, additional

Published
2021
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93. P73 CONTRIBUTION TO THE IMPROVEMENT OF CARDIAC LOAD BY RADICAL SURGERY FOR ADVANCED ESOPHAGEAL HIATAL HERNIA

Author

Tanabe Shunsuke, Fujiwara Toshiyoshi, Shirakawa Yasuhiro, Maeda Naoaki, and Noma Kazuhiro

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Medicine, General Medicine, Radical surgery, business, Esophageal hiatal hernia, digestive system diseases, Surgery
Abstract

Aim The aim of this study is to clarify whether radical surgery for advanced esophageal hiatal hernia contribute to the improvement of cardiac load. Background & Methods In Japan, endoscopic surgery for esophageal hiatal hernia is increasing. In many cases, patients with mixed type hernia have the main symptom of meal passage disorder due to gastric torsion. On the other hand, there are cases in which the contents of hernia squeeze the heart and lung and the symptoms of respiratory and circulatory system get worse. And there are cases where cardiac load is exacerbated and QOL is got worse. Therefore, in addition to conventional surgical adaptation criteria such as vomiting and food loss, cardiac load aggravation may be added to the new surgical adaptation criteria. In this study, we measured BNP before and after surgery in the case of mixed type hiatal hernia who underwent surgery at our hospital, and examined changes in cardiac load. Our surgical procedure of laparoscopic fundoplication is basically toupet fundplication. In the elderly patients, the formation of toupet fundplication is about half a cycle, which is slightly looser than usual, in order to avoid passage obstruction of the wrap. If the esophageal hiatus is too large and it is difficult to suture closure, try to reduce the air pressure of laparoscopic surgery as much as possible to reduce the resistance to the suture closure. And we try not to damage the diaphragm leg. Results We experienced 70 esophageal hiatal hernia surgeries in 2012-2018 and 45 patient had mixed type hiatal hernia. In mixed type hiatal hernia case, 18 cases (40.0%) had chest symptoms such as fatigue and dyspnea on exertion. And there were 12 cases in which BNP could be measured before and after surgery as an evaluation for the presence of cardiac load. Postoperative BNP decreased in 11 of 12 cases from preoperative values. Almost all cases chest symptoms improved. In the above 45 cases, there have been no cases of reoperation and very few cases have taken proton pump inhibitors after surgery. Conclusion Surgical cases of giant hiatal hernia may increase in the future, especially in the elderly. Surgery for giant hiatal hernia can contribute to the improvement of cardiac load.

Published
2019

98. Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer

Author

Ishikawa, Wataru, primary, Kikuchi, Satoru, additional, Ogawa, Toshihiro, additional, Tabuchi, Motoyasu, additional, Tazawa, Hiroshi, additional, Kuroda, Shinji, additional, Noma, Kazuhiro, additional, Nishizaki, Masahiko, additional, Kagawa, Shunsuke, additional, Urata, Yasuo, additional, and Fujiwara, Toshiyoshi, additional

Published
2020
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