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52. A Multi-Population Multi-Objective Evolutionary Algorithm Based on the Contribution of Decision Variables to Objectives for Large-Scale Multi/Many-Objective Optimization

Author

Xu, Ying, Xu, Chong, Zhang, Huan, Huang, Lei, Liu, Yiping, Nojima, Yusuke, and Zeng, Xiangxiang

Abstract

Most existing multiobjective evolutionary algorithms treat all decision variables as a whole to perform genetic operations and optimize all objectives with one population at the same time. Considering different control attributes, different decision variables have different optimization effects on each objective, so decision variables can be divided into convergence- or diversity-related variables. In this article, we propose a new metric called the optimization degree of the convergence-related decision variable to each objective to calculate the contribution objective of each decision variable. All decision variables are grouped according to their contribution objectives. Then, a multiobjective evolutionary algorithm, namely, decision variable contributing to objectives evolutionary algorithm (DVCOEA), has been proposed. In order to balance the convergence and diversity of the population, the DVCOEA algorithm combines the multipopulation multiobjective framework, where two different optimization strategies are designed to optimize the subpopulation and individuals in the external archive, respectively. Finally, DVCOEA is compared with several state-of-the-art algorithms on a number of benchmark functions. Experimental results show that DVCOEA is a competitive approach for solving large-scale multi/many-objective problems.

Published
2023
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55. Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting

Author

Aizawa, Yoshihiro, primary, Takada, Kentaro, additional, Aoyama, Jun, additional, Sano, Daisuke, additional, Yamanaka, Shoji, additional, Seki, Masahide, additional, Kuze, Yuta, additional, Ramilowski, Jordan A., additional, Okuda, Ryo, additional, Ueno, Yasuharu, additional, Nojima, Yusuke, additional, Inayama, Yoshiaki, additional, Hatakeyama, Hiromitsu, additional, Hatano, Takashi, additional, Takahashi, Hideaki, additional, Nishimura, Goshi, additional, Fujii, Satoshi, additional, Suzuki, Yutaka, additional, Taniguchi, Hideki, additional, and Oridate, Nobuhiko, additional

Published
2022
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61. Greedy Approximation Algorithms for Generalized Maximum Flow Problem towards Relation Extraction in Information Networks

Author

Nojima, Yusuke, Asano, Yasuhito, Yoshikawa, Masatoshi, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Akiyama, Jin, editor, Kano, Mikio, editor, and Sakai, Toshinori, editor

Published
2013
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64. Difficulty in Evolutionary Multiobjective Optimization of Discrete Objective Functions with Different Granularities

Author

Ishibuchi, Hisao, Yamane, Masakazu, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Purshouse, Robin C., editor, Fleming, Peter J., editor, Fonseca, Carlos M., editor, Greco, Salvatore, editor, and Shaw, Jane, editor

Published
2013
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65. Relation between Neighborhood Size and MOEA/D Performance on Many-Objective Problems

Author

Ishibuchi, Hisao, Akedo, Naoya, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Purshouse, Robin C., editor, Fleming, Peter J., editor, Fonseca, Carlos M., editor, Greco, Salvatore, editor, and Shaw, Jane, editor

Published
2013
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66. Ensemble Fuzzy Rule-Based Classifier Design by Parallel Distributed Fuzzy GBML Algorithms

Author

Ishibuchi, Hisao, Yamane, Masakazu, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Bui, Lam Thu, editor, Ong, Yew Soon, editor, Hoai, Nguyen Xuan, editor, Ishibuchi, Hisao, editor, and Suganthan, Ponnuthurai Nagaratnam, editor

Published
2012
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67. Recombination of Similar Parents in SMS-EMOA on Many-Objective 0/1 Knapsack Problems

Author

Ishibuchi, Hisao, Akedo, Naoya, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Coello, Carlos A. Coello, editor, Cutello, Vincenzo, editor, Deb, Kalyanmoy, editor, Forrest, Stephanie, editor, Nicosia, Giuseppe, editor, and Pavone, Mario, editor

Published
2012
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68. Mobile Robot Controller Design by Evolutionary Multiobjective Optimization in Multiagent Environments

Author

Nojima, Yusuke, Ishibuchi, Hisao, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Jeschke, Sabina, editor, Liu, Honghai, editor, and Schilberg, Daniel, editor

Published
2011
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69. Effects of the Existence of Highly Correlated Objectives on the Behavior of MOEA/D

Author

Ishibuchi, Hisao, Hitotsuyanagi, Yasuhiro, Ohyanagi, Hiroyuki, Nojima, Yusuke, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Takahashi, Ricardo H. C., editor, Deb, Kalyanmoy, editor, Wanner, Elizabeth F., editor, and Greco, Salvatore, editor

Published
2011
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73. Parallel Distributed Implementation of Genetics-Based Machine Learning for Fuzzy Classifier Design

Author

Nojima, Yusuke, Mihara, Shingo, Ishibuchi, Hisao, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Deb, Kalyanmoy, editor, Bhattacharya, Arnab, editor, Chakraborti, Nirupam, editor, Chakroborty, Partha, editor, Das, Swagatam, editor, Dutta, Joydeep, editor, Gupta, Santosh K., editor, Jain, Ashu, editor, Aggarwal, Varun, editor, Branke, Jürgen, editor, Louis, Sushil J., editor, and Tan, Kay Chen, editor

Published
2010
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74. Many-Objective Test Problems to Visually Examine the Behavior of Multiobjective Evolution in a Decision Space

Author

Ishibuchi, Hisao, Hitotsuyanagi, Yasuhiro, Tsukamoto, Noritaka, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Schaefer, Robert, editor, Cotta, Carlos, editor, Kołodziej, Joanna, editor, and Rudolph, Günter, editor

Published
2010
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75. How to Choose Solutions for Local Search in Multiobjective Combinatorial Memetic Algorithms

Author

Ishibuchi, Hisao, Hitotsuyanagi, Yasuhiro, Wakamatsu, Yoshihiko, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Schaefer, Robert, editor, Cotta, Carlos, editor, Kołodziej, Joanna, editor, and Rudolph, Günter, editor

Published
2010
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78. Adaptation of Scalarizing Functions in MOEA/D: An Adaptive Scalarizing Function-Based Multiobjective Evolutionary Algorithm

Author

Ishibuchi, Hisao, Sakane, Yuji, Tsukamoto, Noritaka, Nojima, Yusuke, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Ehrgott, Matthias, editor, Fonseca, Carlos M., editor, Gandibleux, Xavier, editor, Hao, Jin-Kao, editor, and Sevaux, Marc, editor

Published
2009
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81. Multiobjective Classification Rule Mining

Author

Ishibuchi, Hisao, Kuwajima, Isao, Nojima, Yusuke, Rozenberg, G., editor, Bäck, Th., editor, Eiben, A.E., editor, Kok, J.N., editor, Spaink, H.P., editor, Amari, S., editor, Brassard, G., editor, Jong, K.A. De, editor, Gielen, C.C.A.M., editor, Head, T., editor, Kari, L., editor, Landweber, L., editor, Martinetz, T., editor, Martinetz, Z., editor, Mozer, M.C., editor, Oja, E., editor, Păun, G., editor, Reif, J., editor, Rubin, H., editor, Salomaa, A., editor, Schoenauer, M., editor, Schwefel, H.-P., editor, Torras, C., editor, Whitley, D., editor, Winfree, E., editor, Zurada, J.M., editor, Knowles, Joshua, editor, Corne, David, editor, Deb, Kalyanmoy, editor, and Chair, Deva Raj, editor

Published
2008
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83. Use of Local Ranking in Cellular Genetic Algorithms with Two Neighborhood Structures

Author

Ishibuchi, Hisao, Tsukamoto, Noritaka, Nojima, Yusuke, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Li, Xiaodong, editor, Kirley, Michael, editor, Zhang, Mengjie, editor, Green, David, editor, Ciesielski, Vic, editor, Abbass, Hussein, editor, Michalewicz, Zbigniew, editor, Hendtlass, Tim, editor, Deb, Kalyanmoy, editor, Tan, Kay Chen, editor, Branke, Jürgen, editor, and Shi, Yuhui, editor

Published
2008
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84. Use of Heuristic Local Search for Single-Objective Optimization in Multiobjective Memetic Algorithms

Author

Ishibuchi, Hisao, Hitotsuyanagi, Yasuhiro, Tsukamoto, Noritaka, Nojima, Yusuke, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Rudolph, Günter, editor, Jansen, Thomas, editor, Beume, Nicola, editor, Lucas, Simon, editor, and Poloni, Carlo, editor

Published
2008
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85. Examining the Effect of Elitism in Cellular Genetic Algorithms Using Two Neighborhood Structures

Author

Ishibuchi, Hisao, Tsukamoto, Noritaka, Nojima, Yusuke, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Rudolph, Günter, editor, Jansen, Thomas, editor, Beume, Nicola, editor, Lucas, Simon, editor, and Poloni, Carlo, editor

Published
2008
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88. Optimization of Scalarizing Functions Through Evolutionary Multiobjective Optimization

Author

Ishibuchi, Hisao, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Obayashi, Shigeru, editor, Deb, Kalyanmoy, editor, Poloni, Carlo, editor, Hiroyasu, Tomoyuki, editor, and Murata, Tadahiko, editor

Published
2007
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91. Finding Simple Fuzzy Classification Systems with High Interpretability Through Multiobjective Rule Selection

Author

Ishibuchi, Hisao, Nojima, Yusuke, Kuwajima, Isao, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Gabrys, Bogdan, editor, Howlett, Robert J., editor, and Jain, Lakhmi C., editor

Published
2006
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92. Effects of Using Two Neighborhood Structures in Cellular Genetic Algorithms for Function Optimization

Author

Ishibuchi, Hisao, Doi, Tsutomu, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Runarsson, Thomas Philip, editor, Beyer, Hans-Georg, editor, Burke, Edmund, editor, Merelo-Guervós, Juan J., editor, Whitley, L. Darrell, editor, and Yao, Xin, editor

Published
2006
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93. Incorporation of Scalarizing Fitness Functions into Evolutionary Multiobjective Optimization Algorithms

Author

Ishibuchi, Hisao, Doi, Tsutomu, Nojima, Yusuke, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Runarsson, Thomas Philip, editor, Beyer, Hans-Georg, editor, Burke, Edmund, editor, Merelo-Guervós, Juan J., editor, Whitley, L. Darrell, editor, and Yao, Xin, editor

Published
2006
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95. Effects of Removing Overlapping Solutions on the Performance of the NSGA-II Algorithm

Author

Nojima, Yusuke, Narukawa, Kaname, Kaige, Shiori, Ishibuchi, Hisao, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Coello Coello, Carlos A., editor, Hernández Aguirre, Arturo, editor, and Zitzler, Eckart, editor

Published
2005
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98. Experimental models of salivary gland cancer established using organoid culture and patient-derived xenografting

Author

Aizawa, Yoshihiro, primary, Takada, Kentaro, additional, Aoyama, Jun, additional, Sano, Daisuke, additional, Yamanaka, Shoji, additional, Seki, Masahide, additional, Kuze, Yuta, additional, Ramilowski, Jordan, additional, Okuda, Ryo, additional, Ueno, Yasuharu, additional, Nojima, Yusuke, additional, Inayama, Yoshiaki, additional, Hatakeyama, Hiromitsu, additional, Hatano, Takashi, additional, Takahashi, Hideaki, additional, Nishimura, Goshi, additional, Fujii, Satoshi, additional, Suzuki, Yutaka, additional, Taniguchi, Hideki, additional, and Oridate, Nobuhiko, additional

Published
2022
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99. GPR56 C‐terminal fragment mediates signal received by N‐terminal fragment of another adhesion GPCR Latrophilin1 in neurons.

Author

Nojima, Yusuke, Toriyama, Manami, Tago, Kenji, Mizuno, Norikazu, Morishita, Kazuhiro, and Itoh, Hiroshi

Subjects
*G protein coupled receptors, *CELL migration, *CELL adhesion, *CELLULAR signal transduction, *NEURONS, *CALCIUM ions
Abstract

Adhesion GPCRs (aGPCRs) are a subfamily of GPCRs that are involved in cell adhesion, cell proliferation, and cell migration in various tissues. G protein‐coupled receptor proteolytic site (GPS) of aGPCR is required to cleave the extracellular domain autocatalytically, generating two fragments; a N‐terminal fragment (NTF) and a C‐terminal fragment (CTF) containing seven transmembrane structure. NTF can interact with CTF non‐covalently after cleavage, however the physiological significance of the cleavage of aGPCR at GPS, and also the interaction between NTF and CTF have not been fully clarified yet. In this study, we first investigated the expression profiles of two aGPCRs, GPR56/ADGRG1, and LPHN1/ADGRL1 in mouse brain, and found that the NTF and CTF of GPR56 independently expressed in different brain region at different developmental stages. Immunoprecipitation of GPR56CTF co‐immunoprecipitated LPHN1NTF from mouse brain and HEK293T cells expressing both fragments. Stimulation with LPHN1 ligand, α‐Latrotoxin N4C (αLTXN4C), to cells expressing LPHN1NTF and GPR56CTF increased intracellular Ca2+ concentration ([Ca2+]i). We also demonstrated that GPR56KO mouse neurons attenuated their Ca2+ response to αLTXN4C. These results suggest the possibility of functional and chimeric complex containing LPHN1NTF and GPR56CTF in neuronal signal transduction. [ABSTRACT FROM AUTHOR]

Published
2023
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