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601 results on '"Nishioka, N"'

54. Plasma orexin-A is lower in patients with narcolepsy

Author

Higuchi, S, primary, Usui, A, additional, Murasaki, M, additional, Matsushita, S, additional, Nishioka, N, additional, Yoshino, A, additional, Matsui, T, additional, Muraoka, H, additional, Ishizuka, Y, additional, Kanba, S, additional, and Sakurai, T, additional

Published
2002
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77. Five-year efficacy and safety of photodynamic therapy with Photofrin in Barrett's high-grade dysplasia.

Author

Overholt BF, Wang KK, Burdick JS, Lightdale CJ, Kimmey M, Nava HR, Sivak MV Jr., Nishioka N, Barr H, Marcon N, Pedrosa M, Bronner MP, Grace M, Depot M, and International Photodynamic Group for High-Grade Dysplasia in Barrett's Esophagus

Abstract

BACKGROUND: Barrett's esophagus (BE) with high-grade dysplasia (HGD) is a risk factor for development of esophageal carcinoma. Photodynamic therapy (PDT) with Photofrin (PHO) has been used to eliminate HGD in BE. OBJECTIVE: Our purpose was to compare PHOPDT plus omeprazole with omeprazole only (OM). DESIGN: Five-year follow-up of a randomized, multicenter, multinational, pathology-blinded HGD trial. SETTING: 30 sites in 4 countries. PATIENTS: 208. INTERVENTIONS: Patients with BE and HGD were randomized (2:1) to PHOPDT (n=138) or OM (n=70) into a 2-year trial followed up for 3 more years. PHOPDT patients received 2 mg/kg PHO intravenously followed by endoscopic laser light exposure of Barrett's mucosa at a wavelength of 630 nm within 40 to 50 hours to a maximum of 3 courses at least 90 days apart. Both groups received 20 mg of OM twice daily. Pathologists at one center assessed biopsy specimens in a blinded fashion. MAIN OUTCOME MEASUREMENT: HGD ablation status over 5 years of follow-up. RESULTS: At 5 years PHOPDT was significantly more effective than OM in eliminating HGD (77% [106/138] vs 39% [27/70], P<.0001). A secondary outcome measure preventing progression to cancer showed a significant difference (P=.027) with about half the likelihood of cancer occurring in PHOPDT (21/138 [15%]) compared with OM (20/70 [29%]), with a significantly (P=.004) longer time to progression to cancer favoring PHOPDT. LIMITATIONS: Not all patients were available for follow-up. CONCLUSIONS: This 5-year randomized trial of BE patients with HGD demonstrates that PHOPDT is a clinically and statistically effective therapy in producing long-term ablation of HGD and reducing the potential impact of cancer compared with OM. [ABSTRACT FROM AUTHOR]

Published
2007
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93. Gastrointestinal: Knuckle guidewire insertion: Safe techniques of guidewire insertion into the pancreatobiliary tract using a novel 0.025‐inch guidewire.

Author

Ogura, T., Yamada, M., Nishioka, N., Yamada, T., and Higuchi, K.

Subjects
PANCREATIC duct
Abstract

In this paper, knuckle guidewire technique for the pancreatic and bile ducts in the ERCP procedure is described. A knuckle shape can prevent pancreatic and bile duct penetration, and it is easily made if this novel guidewire is used. In conclusion, knuckle guidewire technique using a novel guidewire may be useful to prevent penetration of the pancreatic and bile ducts. [Extracted from the article]

Published
2020
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95. Serotypes of bovine rotaviruses distinguished by serum neutralization

Author

Murakami, Y, Nishioka, N, Hashiguchi, Y, and Kuniyasu, C

Abstract

Fourteen cytopathic bovine rotaviruses isolated from naturally affected calves were characterized serologically by serum neutralization. Antisera were prepared in guinea pigs against the three isolates and the Lincoln strain of bovine rotavirus. These four rotaviruses were segregated into at least two distinct serotypes (designated types 1 and 2) by serum neutralization. The remaining 11 isolates were also placed into two groups according to neutralization specificity by using the antisera against types 1 and 2 bovine rotavirus. When colostrum-deprived calves were experimentally inoculated with type 1 or 2 bovine rotavirus, respectively, the calves produced neutralizing antibodies against the inoculated serotype but not against the other serotype. Calf sera obtained from six herds with naturally occurring rotavirus infections possessed neutralizing antibodies against type 1 or 2 or both. Thus, distinct serotypes of bovine rotavirus were demonstrated by serum neutralization. The possible role of serotypes in the epidemiology of rotavirus infection among bovine species is discussed.

Published
1983
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