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69 results on '"Nirel, Ronit"'

52. ATMGermline Pathogenic Variants Affect Treatment Outcomes in Children with Acute Lymphoblastic Leukemia/Lymphoma and Ataxia Telangiectasia

Author

Elitzur, Sarah, Shiloh, Ruth, Loeffen, Jan, Pastorczak, Agata, Takagi, Masatoshi, Bomken, Simon, Baruchel, Andre, Ducassou, Stephane, Mahlaoui, Nizar, Strullu, Marion, Lehrnbecher, Thomas, Schmiegelow, Kjeld, Abla, Oussama, Anderzhanova, Liliia, Arad-Cohen, Nira, Astigarraga, Itziar, Ben-Harosh, Miriam, Ceppi, Francesco, Bodmer, Nicole, Brozou, Triantafyllia, Dalla-Pozza, Luciano, Escherich, Gabriele, Farah, Roula, Gibson, Amber, Hasle, Henrik, Hoveyan, Julieta, Jacoby, Elad, Jazbec, Janez, Kolenova, Alexandra, Lazic, Jelena, Lo Nigro, Luca, Miller, Lane, Papadakis, Vassilios, Pecheux, Lucie, Pillon, Marta, Sarouk, Ifat, Stary, Jan, Stiakaki, Eftichia, Tasian, Sarah K., Tran, Thai Hoa, Ussowicz, Marek, Verdu-Amoros, Jose Jaime, Wakulinska, Anna, Zawitkowska, Joanna, Stoppa-Lyonnet, Dominique, Taylor, Malcolm, Shiloh, Yosef, Izraeli, Shai, Nirel, Ronit, Minard-Colin, Veronique, Attarbaschi, Andishe, and Borkhardt, Arndt

Abstract

IntroductionAtaxia telangiectasia (A-T) is a multisystem disorder caused by biallelic germline pathogenic variants (PV) in the ATM gene. An important feature of A-T is an increased predisposition to cancer with a reported incidence of 25%, primarily attributed to hematological malignancies. Patients with A-T and cancer are usually excluded from therapeutic clinical trials, limited information thus exists concerning their treatment outcomes and toxicity profiles and consequently, optimal management strategies are unclear and an unmet need. In this multinational study, we aimed to investigate the characteristics and outcomes of leukemia and lymphoma in a large cohort of children with A-T and to determine risk factors which impact treatment outcome in order to generate consensus and data-based prospective treatment recommendations.

Published
2023
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55. Characteristics and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia: Comparison Between Ethnic Populations in Israel

Author

Elhasid, Ronit, primary, Abramov, Aya, additional, Arad -Cohen, Nira, additional, Attias, Dina, additional, Avrahami, Galia, additional, Ballin, Ami, additional, Ben Arush, Myriam, additional, Bielorai, Bella, additional, Burstein, Yoav, additional, Elitzur, Sara, additional, Gavriel, Hertzel, additional, Kapelushnik, Joseph, additional, Sthoeger, Dalia, additional, Toren, Amos, additional, Yaniv, Isaac, additional, Wientraub, Michael, additional, Nirel, Ronit, additional, Izraeli, Shai, additional, and Stark, Batia, additional

Published
2014
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62. Characteristics and Outcome of Adolescents with Acute Lymphoblastic Leukemia (ALL) Differ from Young Children in the B-Cell Lineage but Not in the T-Cell Lineage: Experience of the ALL Israeli National Studies (INS).

Author

Elhasid, Ronit, primary, Avrahami, Gali, additional, Abramov, Aya, additional, Attias, Dina, additional, Ballin, Ami, additional, Bielorai, Bella, additional, Burstein, Yoav, additional, Gavriel, Herzel, additional, Kapelushnik, Joseph, additional, Miskin, Hagit, additional, Sthoeger, Dalia, additional, Weintraub, Michael, additional, Stein, Jerry, additional, Yaniv, Isaac, additional, Toren, Amos, additional, Ben Arush, Myriam, additional, Nirel, Ronit, additional, Izraeli, Shai, additional, and Stark, B., additional

Published
2008
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68. Poorer outcome of childhood acute lymphoblastic leukemia in the Bedouin population: A report from the Berlin-Frankfurt-Muenster-based Israeli national protocols.

Author

Elhasid, Ronit, Nirel, Ronit, Avigad, Smadar, Avrahami, Gali, Abramov, Aya, Attias, Dina, Arad, Nira, Ballin, Ami, Ben‐Arush, Myriam, Bielorai, Bella, Burstein, Yoav, Elitzur, Sarah, Gabriel, Herzel, Hameiri‐Grossman, Michal, Kapelushnik, Joseph, Sthoeger, Dalia, Toren, Amos, Wientraub, Michael, Yaniv, Isaac, and Izraeli, Shai

Published
2020
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69. Mother-level random effect in the association between PM 2.5 and fetal growth: A population-based pregnancy cohort.

Author

Ahmad WA, Nirel R, Golan R, Jolles M, Kloog I, Rotem R, Negev M, Koren G, and Levine H

Subjects
Female, Gestational Age, Humans, Infant, Newborn, Maternal Exposure, Mothers, Particulate Matter analysis, Particulate Matter toxicity, Pregnancy, Air Pollutants analysis, Air Pollutants toxicity, Air Pollution
Abstract

Background: A growing body of literature reports associations between exposure to particulate matter with diameter ≤2.5 μm (PM 2.5 ) during pregnancy and birth outcomes. However, findings are inconsistent across studies., Objectives: To assess the association between PM 2.5 and birth outcomes of fetal growth in a cohort with high prevalence of siblings by multilevel models accounting for geographical- and mother-level correlations., Methods: In Israel, we used Maccabi Healthcare Services data to establish a population-based cohort of 381,265 singleton births reaching 24-42 weeks' gestation and birth weight of 500-5000 g (2004-2015). Daily PM 2.5 predictions from a satellite-based spatiotemporal model were linked to the date of birth and maternal residence. We generated mean PM 2.5 values for the entire pregnancy and for exposure periods during pregnancy. Associations between exposure and birth outcomes were modeled by using multilevel logistic regression with random effects for maternal locality of residence, administrative census area (ACA) and mother., Results: In fully adjusted models with a mother-level random intercept only, a 10-μg/m 3 increase in PM 2.5 over the entire pregnancy was positively associated with term low birth weight (TLBW) (Odds ratio, OR = 1.25, 95% confidence interval, CI: 1.09,1.43) and small for gestational age (SGA) (OR = 1.15, 95% CI: 1.06,1.26). Locality- and ACA-level effects accounted for <0.4% of the variance while mother-level effects explained ∼50% of the variability. Associations varied by exposure period, infants' sex, birth order, and maternal pre-pregnancy BMI., Conclusions: Consideration of mother-level variability in a region with high fertility rates provides new insights on the strength of associations between PM 2.5 and birth outcomes., (Copyright © 2022. Published by Elsevier Inc.)

Published
2022
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