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53. Micropatterning of electrochemiluminescent polymers based on multipolar Ru-complex two-photon initiators

Author

Rana Mhanna, Nicolas Durand, Paul Savel, Huriye Akdas-Kiliç, Stephania Abdallah, Davy-Louis Versace, Olivier Soppera, Jean-Luc Fillaut, Neso Sojic, Jean-Pierre Malval, Jonchère, Laurent, Institut de Science des Matériaux de Mulhouse (IS2M), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Yildiz Technical University (YTU), Institut de Chimie et des Matériaux Paris-Est (ICMPE), Institut de Chimie du CNRS (INC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.POLY] Chemical Sciences/Polymers, [CHIM.POLY]Chemical Sciences/Polymers, [SPI.NANO] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, Materials Chemistry, Metals and Alloys, Ceramics and Composites, [CHIM.COOR]Chemical Sciences/Coordination chemistry, General Chemistry, [CHIM.COOR] Chemical Sciences/Coordination chemistry, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Abstract

International audience; In this work, we present an original stereolithography strategy based on multibranched Ru-complexes with a high two-photon initiating ability allowing the ’one-pot’ direct laser writing of ECL-active materials deposited onto electro-active surfaces at the μm scale.

Published
2022
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63. Neuroligin 1 expression is linked to plasticity of behavioral and neuronal responses to sex pheromone in the male moth Agrotis ipsilon

Author

Paleo Aguilar, Elodie Demondion, Stéphane Debernard, Nicolas Durand, Françoise Bozzolan, Thomas Bourgeois, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), and Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Male, Olfactory system, Physiology, Cell Adhesion Molecules, Neuronal, Mating behavior, Agrotis ipsilon, Neuroligin, Moth, Sex pheromone, Moths, Aquatic Science, 03 medical and health sciences, 0302 clinical medicine, Olfactory plasticity, medicine, Animals, Sex Attractants, Mating, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Neurons, 0303 health sciences, biology, Neuroligin 1, biology.organism_classification, Antennal lobes, Cell biology, medicine.anatomical_structure, Odor, Insect Science, Pheromone, Female, Animal Science and Zoology, Antennal lobe, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, 030217 neurology & neurosurgery
Abstract

In the moth Agrotis ipsilon, the behavioral response of males to the female-emitted sex pheromone increases throughout adult life and following a prior exposure to sex pheromone, whereas it is temporally inhibited after the onset of mating. This behavioral flexibility is paralleled with changes in neuronal sensitivity to pheromone signal within the primary olfactory centers, the antennal lobes. In the present study, we tested the hypothesis that neuroligins, post-synaptic transmembrane proteins known to act as mediators of neuronal remodeling, are involved in the olfactory modulation in A. ipsilon males. We cloned a full-length cDNA encoding neuroligin 1, which is expressed predominantly in brain and especially in antennal lobes. The level of neuroligin 1 expression in antennal lobes gradually raised from day-2 until day-4 of adult life, as well as at 24 h, 48 h and 72 h following pre-exposure to sex pheromone, and the temporal dynamic of these changes correlated with increased sex pheromone responsiveness. By contrast, there was no significant variation in antennal lobe neuroligin 1 expression during the post-mating refractory period. Taken together, these results highlight that age- and odor experience-related increase in sex pheromone responsiveness is linked to the overexpression of neuroligin 1 in antennal lobes, thus suggesting a potential role played by this post-synaptic cell-adhesion molecule in mediating the plasticity of the central olfactory system in A. ipsilon.

Published
2021
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67. Parce que c’est nous

Author

Nicolas Durand and Nicolas Durand

Abstract

Ne dit-on pas que le bonheur arrive lorsqu'on s'y attend le moins? Rien ne prédestinait Rayan, jeune homme solaire à qui tout réussit, à croiser Clément, solitaire, inlassable rêveur, un brin naïf. Pourtant, leur rencontre inopinée, dans des circonstances dramatiques, donnera naissance à une amitié sincère, forte et touchante. Parce que c'est nous est une histoire tumultueuse où les aventures des uns et des autres s'entremêlent et s'entrechoquent parfois. La subtilité de la nouvelle est de mêler toutes les péripéties et de dévoiler ainsi, peu à peu, la destinée de chacun et les liens entre les protagonistes avec un suspens prenant.À PROPOS DE L'AUTEURNicolas Durand a toujours travaillé dur pour réussir, au point d'oublier de vivre, jusqu'au jour où il a fait la rencontre de sa vie, celle de son meilleur ami, malgré leurs différences, culture, religion, personnalité. Ce coup de foudre amical a nourri son imagination, sa compréhension de l'être humain et a inspiré l'écriture de ce livre.

Published
2023

68. Un cœur pour deux

Author

Nicolas Durand and Nicolas Durand

Abstract

'Un cœur pour deux'est une histoire riche en émotions et un exceptionnel témoignage d'amitié entre Ryan et Clément. Ce dernier, ayant appris que son meilleur ami est hospitalisé après une sévère crise cardiaque, abandonne toute activité et se rend à son chevet à l'autre bout de la France. Au fil des jours, Rayan délivre des préceptes de vie invitant Clément et le lecteur à s'interroger sur la quête du bonheur et sur la réussite de la vie. Derrière ces enseignements se cache une énigme que Clément tente de résoudre… Ce récit, dont le dénouement est pour le moins inattendu, nous plonge dans les intrications de la relation amicale, dévoilant ses multiples facettes, ses défis et ses beautés.À PROPOS DE L'AUTEURAuteur de'Parce que c'est nous', Nicolas Durand revient avec'Un cœur pour deux', récit dans lequel il explore les liens profonds et précieux qui unissent les individus, capturant les émotions sincères et les moments inoubliables partagés entre amis. Son expérience amicale transcende les pages pour toucher les cœurs, rappelant que l'amitié est un trésor inestimable dans nos vies.

Published
2023

69. Involvement of Methoprene-tolerant and Krüppel homolog 1 in juvenile hormone-signaling regulating the maturation of male accessory glands in the moth Agrotis ipsilon

Author

Paleo Aguilar, Elodie Demondion, Françoise Bozzolan, Edmundo Gassias, Annick Maria, Nicolas Durand, Stéphane Debernard, and Philippe Couzi

Subjects
0106 biological sciences, Male, DNA, Complementary, Kruppel-Like Transcription Factors, Methoprene, Agrotis ipsilon, Moths, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Animals, Receptor, Gonads, Molecular Biology, Transcription factor, 030304 developmental biology, 0303 health sciences, Gene knockdown, biology, Reproduction, Metamorphosis, Biological, Gene Expression Regulation, Developmental, biology.organism_classification, Cell biology, Juvenile Hormones, 010602 entomology, Fertility, nervous system, chemistry, Insect Science, Larva, Juvenile hormone, Insect Proteins, Signal transduction, Sesquiterpenes, Hormone, Signal Transduction
Abstract

Male accessory glands (MAGs) produce seminal fluid proteins that are essential for the fertility and also influence the reproductive physiology and behavior of mated females. In many insect species, and especially in the moth Agrotis ipsilon, juvenile hormone (JH) promotes the maturation of the MAGs but the underlying molecular mechanisms in this hormonal regulation are not yet well identified. Here, we examined the role of the JH receptor, Methoprene-tolerant (Met) and the JH-inducible transcription factor, Kruppel homolog 1 (Kr-h1) in transmitting the JH signal that upregulates the growth and synthetic activity of the MAGs in A. ipsilon. We cloned two full length cDNAs encoding Met1 and Met2 which are co-expressed with Kr-h1 in the MAGs where their expression levels increase with age in parallel with the length and protein content of the MAGs. RNAi-mediated knockdown of either Met1, Met2, or Kr-h1 resulted in reduced MAG length and protein amount. Moreover, injection of JH-II into newly emerged adult males induced the transcription of Met1, Met2 and Kr-h1 associated to an increase in the length and protein content of the MAGs. By contrast, JH deficiency decreased Met1, Met2 and Kr-h1 mRNA levels as well as the length and protein reserves of the MAGs of allatectomized old males and these declines were partly compensated by a combined injection of JH-II in operated males. Taken together, our results highlighted an involvement of the JH-Met-Kr-h1 signaling pathway in the development and secretory activity of the MAGs in A. ipsilon.

Published
2020

70. Ant Colony Systems for Optimizing Sequences of Airspace Partitions

Author

Nicolas Durand, David Gianazza, and Ecole Nationale de l'Aviation Civile (ENAC)

Subjects
0209 industrial biotechnology, Mathematical optimization, Situation awareness, Airspace configuration, Computer science, A* search algorithm, Branch & bound, ComputerApplications_COMPUTERSINOTHERSYSTEMS, 02 engineering and technology, Workload, law.invention, 020901 industrial engineering & automation, law, Airspace partition, 0202 electrical engineering, electronic engineering, information engineering, Ant colony optimization algorithms, Air traffic management, Ant colony, Air traffic control, Tree search, Ant Colony Optimization, A* algorithm, Ant Colony System, 020201 artificial intelligence & image processing, A_star algorithm, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Airspace class
Abstract

International audience; In this paper, we introduce an Ant Colony System algorithm which finds optimal or near-optimal sequences of airspace partitions, taking into account some constraints on the transitions between two successive airspace configurations. The transitions should be simple enough to allow air traffic controllers to maintain their situation awareness during the airspace configuration changes. For the same reason, once a sector is opened it should remain so for a minimum duration. The Ant Colony System (ACS) finds a sequence of airspace configurations minimizing a cost related to the workload and the usage of manpower resources, while satisfying the transition constraints. This approach shows good results in a limited time when compared with a previously proposed $A$ * algorithm on some instances from the french air traffic control center of Aix (East qualification zone) where the $A$ * algorithm exhibited high computation times.00

Published
2020
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71. Unexpected disruption of the dimensionality-driven two-photon absorption enhancement within a multipolar polypyridyl ruthenium complex series

Author

Huriye Akdas-Kiliç, Jean-Luc Fillaut, Rana Mhanna, Jean-Pierre Malval, Nicolas Durand, Olivier Soppera, Paul Savel, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Science des Matériaux de Mulhouse (IS2M), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)

Subjects
Materials science, Series (mathematics), 010405 organic chemistry, Metals and Alloys, chemistry.chemical_element, General Chemistry, 010402 general chemistry, 01 natural sciences, Two-photon absorption, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Ruthenium, chemistry, Chemical physics, Materials Chemistry, Ceramics and Composites, [CHIM]Chemical Sciences, Absorption (electromagnetic radiation), Curse of dimensionality
Abstract

International audience; The dimensionality-driven two-photon absorption (2PA) enhancement effect is investigated in a series of functionalized bipyridyl Ru-complexes. Our design strategy leads to very high 2PA responses up to ∼1500 GM. However, we highlight that the 2PA performance vs. dimensionality correlation reaches an unexpected limit stemming from 'anti-cooperative' interchromophoric couplings.

Published
2020
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72. Understanding and overcoming horizontal separation complexity in air traffic control: an expert/novice comparison

Author

Jean-Baptiste Gotteland, Léa Bortolotti, Margot Sandt, Nicolas Durand, Nadine Matton, Ecole Nationale de l'Aviation Civile (ENAC), and Direction Générale de l'Aviation Civile (DGAC)

Subjects
decision support tool, Conflict detection, SIMPLE (military communications protocol), Computer science, Trainer, 05 social sciences, Separation (aeronautics), ComputerApplications_COMPUTERSINOTHERSYSTEMS, Visualization tool, Air traffic control, 050105 experimental psychology, Computer Science Applications, Task (project management), Visualization, Human-Computer Interaction, Philosophy, air traffic complexity, Dynamic visualization, [SCCO.PSYC]Cognitive science/Psychology, Key (cryptography), 0501 psychology and cognitive sciences, 050107 human factors, Simulation
Abstract

International audience; Humans still play a key role in air traffic control but their performances limit the capacity of the airspace and are responsible for delays. At the tactical level, even though air traffic controllers (ATCO) are trained for years, their performances are limited. In this article, we first isolated the tactical horizontal deconfliction task and explained its mathematical complexity. We observed through a simple experiment conducted on trainee and experienced ATCOs its complexity on random traffic in a part-task trainer displaying two to five aircraft trajectories at the same altitude. We compared performances of trainee ATCOs with experienced ATCOs using two different displays: a basic display showing information on aircraft positions and a dynamic visualization tool that represents the conflicting portions of aircraft trajectories and the evolution of the conflict zone when the user adds a maneuver to an aircraft. The tool allows the user to dynamically check the potential conflicting zones with the computer mouse before making a maneuver decision. Results showed that in easy situations (two aircraft), performance was similar with both displays and groups. However, as the complexity of the situations grows (from three to five aircraft), the dynamic visualization tool enables users to solve the conflicts more efficiently. Using the tool leads to fewer unsolved conflicts. Even if experienced ATCOs performed much better than trainee ATCOs on complex situations, they also performed much better with the conflict visualization tool than without on such situations.

Published
2020
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74. Constant speed optimal reciprocal collision avoidance

Author

Nicolas Durand and Ecole Nationale de l'Aviation Civile (ENAC)

Subjects
air traffic, Computer science, Self-separation, Constant speed, Transportation, 02 engineering and technology, Management Science and Operations Research, Control theory, 0502 economics and business, Conflict resolution, 0202 electrical engineering, electronic engineering, information engineering, CSORCA, Civil and Structural Engineering, 050210 logistics & transportation, 05 social sciences, Relative velocity, self-separation, Air traffic control, Horizontal plane, geometrical algorithm, Norm (mathematics), Automotive Engineering, 020201 artificial intelligence & image processing, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], ORCA, Reciprocal
Abstract

International audience; In this article, the Optimal Reciprocal Collision Avoidance (ORCA) algorithm is modified to make it work for speed constrained aircraft. The adaptation of ORCA to aircraft conflict resolution shows that when the speed norm is constrained, aircraft flying within the same speed range with small angle converging trajectories tend to remain on parallel tracks, preventing a resolution of the conflict. The ORCA algorithm is slightly modified to avoid this behavior. In the new algorithm called CSORCA (Constant Speed Optimal Reciprocal Collision Avoidance), the directions of the semi-plane used to calculate the conflict free maneuvers are modified when the relative speed vector is in the semi-circular part of the conflicting area. After explaining the reasons that make the original algorithm fail in the constant speed environment, the modification made on the algorithm is detailed and its impact on a simple example is shown. The new strategy is also compared to an Add-Up strategy close to the Airborne Separation Assurance System (ASAS) strategy found in the literature. Hundreds of fast time simulations are then performed to compare the two versions of the algorithm for different traffic densities in the horizontal plane. In these simulations the speed norm is first constrained. The aircraft can only change direction with a limited turning rate. Simulations with released speed constraints are then performed to compare the behavior of both algorithms in a more general environment. In all the scenarios tested, CSORCA is more efficient than ORCA to solve conflicts.

Published
2018
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75. Evidence for a role of oestrogen receptor-related receptor in the regulation of male sexual behaviour in the mothAgrotis ipsilon

Author

Elisabeth Gassias, Stéphane Debernard, Thomas Bourgeois, Nicolas Durand, Elodie Demondion, and Françoise Bozzolan

Subjects
0301 basic medicine, Genetics, medicine.medical_specialty, Gene knockdown, biology, Estrogen receptor, Agrotis ipsilon, biology.organism_classification, Homology (biology), 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Insect Science, Internal medicine, Sex pheromone, medicine, Pheromone, Receptor, Molecular Biology, Gene, 030217 neurology & neurosurgery
Abstract

The oestrogen receptor-related receptors (ERRs) are orphan nuclear receptors that were originally identified on the basis of their close homology to the oestrogen receptors. The three mammalian ERR genes participate in the regulation of vital physiological processes including reproduction, development and metabolic homeostasis. Although unique ERRs have been found in insects, data on the function and regulation of these receptors remain sparse. In the present study, a 2095-bp full-length cDNA encoding an ERR, termed AiERR, was isolated from males of the moth Agrotis ipsilon and deposited in the GenBank database under the accession number KT944662. The predicted AiERR protein shared an overall identity of 47–82% with other known insect and mammalian ERR homologues. AiERR exhibited a broad tissue expression pattern with the detection of one transcript of approximately 2 kb in the primary olfactory centres, the antennal lobes (AL). In adult males, the amount of AiERR mRNA in the AL increased concomitantly with age and responses to the female-emitted sex pheromone. Moreover, AiERR knockdown induced an inhibition in the sex pheromone-orientated flight of male. Using A. ipsilon as a model, our study demonstrates that the insect ERR is critical for the performance of male sexual behaviour, probably by acting on central pheromone processing.

Published
2017
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76. A critical role for Dop1-mediated dopaminergic signaling in the plasticity of behavioral and neuronal responses to sex pheromone in a moth

Author

Elodie Demondion, Françoise Bozzolan, Paleo Aguilar, Stéphane Debernard, Edmundo Gassias, Thomas Bourgeois, Nicolas Durand, Institute of Biology, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
0106 biological sciences, Male, Sexual behavior, Physiology, 030310 physiology, Dopamine, Agrotis ipsilon, Aquatic Science, Moths, Dop1 receptor, 010603 evolutionary biology, 01 natural sciences, Adenylyl cyclase, 03 medical and health sciences, chemistry.chemical_compound, Sexual Behavior, Animal, Olfactory plasticity, Neuromodulation, medicine, Animals, Sex Attractants, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 0303 health sciences, biology, [SDV.BA]Life Sciences [q-bio]/Animal biology, Dopaminergic, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, biology.organism_classification, Insects, medicine.anatomical_structure, chemistry, Dopamine receptor, Insect Science, Sex pheromone, Pheromone, Animal Science and Zoology, Female, Neuroscience, medicine.drug, Signal Transduction
Abstract

Most animal species, including insects, are able to modulate their responses to sexual chemosignals and this flexibility originates from the remodeling of olfactory areas under the influence of dopaminergic system. In the moth Agrotis ipsilon, the behavioral response of males to the female-emitted sex pheromone increases throughout adult life and after a prior exposure to pheromone signal and this change is accompanied by an increase in neuronal sensitivity within the primary olfactory centers, the antennal lobes (ALs). To identify the underlying neuromodulatory mechanisms, we examined whether this age- and experience-dependent olfactory plasticity is mediated by dopamine (DA) through the Dop1 receptor, an ortholog of the vertebrate D1-type dopamine receptors, which is positively coupled to adenylyl cyclase. We cloned A. ipsilon Dop1 (AiDop1) which is expressed predominantly in brain and especially in ALs and its knockdown induced decreased AL cAMP amounts and altered sex pheromone-orientated flight. The levels of DA, AiDop1 expression and cAMP in ALs increased from the third day of adult life and at 24h and 48h following pre-exposure to sex pheromone and the dynamic of these changes correlated with the increased responsiveness to sex pheromone. These results demonstrate that Dop1 is required for the display of male sexual behavior and that age- and experience-related neuronal and behavioral changes are sustained by DA-Dop1 signaling that operates within ALs probably through cAMP-dependent mechanisms in A. ipsilon. Thus, this study expands our understanding of the neuromodulatory mechanisms underlying olfactory plasticity, mechanisms that appear to be highly conserved between insects and mammals.

Published
2019
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77. Editorial: Insect Olfactory Proteins (From Gene Identification to Functional Characterization)

Author

Shuang-Lin Dong, Peng He, and Nicolas Durand

Subjects
lcsh:QP1-981, Physiology, media_common.quotation_subject, odorant-degrading enzymes, odorant-binding proteins, odorant receptors, Computational biology, Insect, Biology, ionotropic receptors, lcsh:Physiology, Physiology (medical), Identification (biology), chemosensory proteins, Gene, media_common
Published
2019
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78. Polypyridyl Ruthenium Complexes: Versatile Tools for Linear and Non-Linear Optics

Author

Jean-Luc Fillaut, Huriye Akdas-Kiliç, Paul Savel, Nicolas Durand, Abdou Boucekkine, Jean-Pierre Malval, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Jonchère, Laurent, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, 010407 polymers, Materials science, business.industry, Metal ions in aqueous solution, Coordination complexes, π-conjugated systems linear optical properties, Nonlinear optics, chemistry.chemical_element, nonlinear optical properties, [CHIM.MATE]Chemical Sciences/Material chemistry, 01 natural sciences, 0104 chemical sciences, Ruthenium, Metal, Crystallography, Nonlinear optical, chemistry, visual_art, visual_art.visual_art_medium, two-photon absorption, Absorption (chemistry), Photonics, business, ruthenium
Abstract

International audience; Coordination complexes have been attracting considerable interest due to their potential nonlinear optical (NLO) properties and applications in optoelectronic and photonic devices. Incorporation of metal atoms into π-conjugated systems allows many variables to be adjusted, such as the nature of ligands and metal ions as well as the symmetry of the complexes. In this paper, new ruthenium(II) complexes of formula [Ru(bpy)2(L)][PF6] and [Ru (L)3][PF6]2 are reported. We studied the influence of the nature of ligands, structural features and symmetry of these complexes on their two-photon absorption properties to provide useful physical and chemical insights for similar ruthenium complexes.

Published
2019

79. Impact of ATCO training and expertise on dynamic spatial abilities

Author

Nadine Matton, Jean-Baptiste Gotteland, Géraud Granger, Nicolas Durand, Ecole Nationale de l'Aviation Civile (ENAC), Cognition, Langues, Langage, Ergonomie (CLLE), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), EAAP : European Association for Aviation psychology, and Matton, Nadine

Subjects
[SHS.PSY] Humanities and Social Sciences/Psychology, [SHS.PSY]Humanities and Social Sciences/Psychology
Abstract

International audience; Dynamic spatial ability is supposed to be involved in a critical process of air traffic controllers, namely conflict detection. The present paper aims at testing whether dynamic spatial ability improves with air traffic control training and/or experience. We designed a laboratory task to assess the performance in predicting if two moving disks would collide or not. We conducted a cross-sectional study with four groups of participants : ATCO trainees at the beginning (N=129), middle (N=80) or end of training (N=66) and experienced ATCOs (N=14). Results suggested on one hand that air traffic control training leads to a decrease in the number of extremely high proportions of undetected collisions from the middle of the training. On the other hand, air traffic control operational experience leads to a decrease in the number of extremely high proportions of falsely detected collisions.

Published
2019

80. Systematics of U–Th disequilibrium in calcrete profiles: Lessons from southwest India

Author

Yanni Gunnell, Bruno Hamelin, Nicolas Durand, Pierre Deschamps, Pierre Curmi, Laboratoire des Sciences de l'Information et des Systèmes ( LSIS ), Aix Marseille Université ( AMU ) -Université de Toulon ( UTLN ) -Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique ( CNRS ), Polytech Marseille, Aix Marseille Université ( AMU ), Institut Pythéas ( OSU PYTHEAS ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement, Plateforme de géochimie isotopique ASTER-CEREGE, Centre européen de recherche et d'enseignement de géosciences de l'environnement ( CEREGE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Collège de France ( CdF ) -Institut National de la Recherche Agronomique ( INRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Collège de France ( CdF ) -Institut National de la Recherche Agronomique ( INRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ), Institut de Recherche pour le Développement ( IRD [France-Ouest] ), Environnement Ville Société / Institut de Recherches Géographiques (EVS/IRG), Université de Lyon (COMUE), Agroécologie [Dijon], Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté ( UBFC ), Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Institut de Recherche pour le Développement (IRD [France-Ouest]), Université de Lyon, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), and Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
weathering profile, 010506 paleontology, [SDV]Life Sciences [q-bio], Geochemistry, Mineralogy, Impure carbonate, 010502 geochemistry & geophysics, 01 natural sciences, chemistry.chemical_compound, Southwest India, impure carbonate, Geochemistry and Petrology, U-series, Parent rock, 0105 earth and related environmental sciences, Isochron, Isochron dating, [ SDV ] Life Sciences [q-bio], Weathering profile, Geology, Secular equilibrium, Authigenic, 15. Life on land, southwest India, Calcrete, Pedogenesis, chemistry, 13. Climate action, calcrete, isochron, Soil horizon, Carbonate
Abstract

EASPEBIOmEAGROSUP; Pedogenic carbonates (calcretes) have often been proposed as possible markers of the pedogenetic processes in soils under semi-arid climate. However, precise chronological constraints on, their formation are required in order to investigate the climatic and paleo-environmental conditions that prevailed during and after their formation, and to improve our understanding of the, physical and chemical conditions that promoted their development and preservation. Moreover, these authigenic calcium carbonate precipitates provide us with an interesting test of the U-Th radioactive disequilibrium dating method, the reliability of which has been demonstrated extensively in aragonitic corals and calcitic continental speleothems, but which remains much more questionable in highly porous, chemically and mineralogically complex media such as soil profiles. We report here U-238-U-234-Th-230 radioactive disequilibrium analyses measured by Thermo-Ionization Mass Spectrometry in calcretes from two sites in southwest India. Since calcretes are impure carbonates mixed with various amounts of parent rock and weathered minerals, all ages must be computed using the isochron technique, involving the extraction of several coeval subsamples from the same soil horizon and U-Th analyses after total dissolution (TSD) method, in order to correct for the detrital component. Th-232 is usually used as index of the detrital contamination, and the isochron age is derived from the isotopic composition (Th-230/U-238; U-234/U-238) of the pure authigenic carbonate end-member of the mixing line. Our results show that each set of samples taken from decimetric blocks is characterized by a well-defined isochron line in a 3-D Osmond diagram (Th-232/U-238; Th-230/U-238; U-234/U-238). The regression lines obtained for most of the samples show probabilities of fit satisfying the mathematical assumptions of the isochron model (in most cases 0.05), and mean square weighted deviations (MSWD) values around 1. The compositions of the end-members are highly variable between the different isochrons, both for the carbonate phase, indicating various ages of cristallisation, and for the detrital phase, indicating various origins and compositions. Notably, our data demonstrate that the detrital component is in all cases out of secular equilibrium, by contrast with the standard paradigm of "dirty carbonate" dating, which is based on the assumption of average continental crust Th/U elemental ratio, and secular equilibrium values of the ((Th-230/U-238) and (U-234/U-238) ratios. At the first site (Coimbatore), we obtain U-Th ages between 304 +/- 38 ka and 44 +/- 2.9 ka (2 sigma) from the base to the top of the profile. These suggest discontinuous precipitation of the different fades in good agreement with micro morphological observations. At the second study site (Gundlupet), the carbonate nodules sampled from two different profiles, yield consistent ages of 200 ka, which suggests that precipitation of nodular carbonate occurred across the entire pediment toposequence during a single event. Surprisingly, in mere contradiction with the standard model of impure carbonate dating, two puzzling samples display "vertical isochrons", i.e., variable Th-232/U-238 without any variation of the Th-230/U-238 and U-234/U-238 ratios. Such patterns require extremely high Th-232/U-238 ratios, in an as yet unidentified detrital phase. Taken at face value, these results suggest that no clear correlation can be inferred between the precipitation of these pedogenic carbonates and major orbitally-driven climate variations recorded in other archives during the last glacial/interglacial cycles.

Published
2016
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81. Expression and modulation of neuroligin and neurexin in the olfactory organ of the cotton leaf wormSpodoptera littoralis

Author

Françoise Bozzolan, Thomas Chertemps, Nicolas Durand, and Martine Maïbèche

Subjects
0301 basic medicine, Olfactory system, animal structures, biology, media_common.quotation_subject, fungi, Central nervous system, Neurexin, Neuroligin, Insect, Olfaction, Spodoptera, biology.organism_classification, General Biochemistry, Genetics and Molecular Biology, Cell biology, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Insect Science, Botany, medicine, Spodoptera littoralis, Agronomy and Crop Science, Ecology, Evolution, Behavior and Systematics, media_common
Abstract

Carboxylesterases are enzymes widely distributed within living organisms. In insects, they have been mainly involved in dietary metabolism and detoxification function. Interestingly, several members of this family called carboxylesterase-like adhesion molecules (CLAMs) have lost their catalytic properties and are mainly involved in neuro/developmental functions. CLAMs include gliotactins, neurotactins, glutactins, and neuroligins. The latter have for binding partner the neurexin. In insects, the function of these proteins has been mainly studied in Drosophila central nervous system or neuromuscular junction. Some studies suggested a role of neuroligins and neurexin in sensory processing but CLAM expression within sensory systems has not been investigated. Here, we reported the identification of 5 putative CLAMs expressed in the olfactory system of the model pest insect Spodoptera littoralis. One neuroligin, Slnlg4-yll and its putative binding partner neurexin SlnrxI were the most expressed in the antennae and were surprisingly associated with olfactory sensilla. In addition, both transcripts were upregulated in male antennae after mating, known to modulate the sensitivity of the peripheral olfactory system in S. littoralis, suggesting that these molecules could be involved in sensory plasticity.

Published
2016
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82. Prédiction de l'état du trafic routier basée sur les motifs et les chaînes de Markov

Author

Feda Almuhisen, Nicolas Durand, Leonardo Brenner, Quafafou Mohamed, Data Mining at scale (DANA), Laboratoire d'Informatique et Systèmes (LIS), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Modèles et Formalismes à Evénements Discrets (MOFED), and Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [SCCO.COMP]Cognitive science/Computer science
Abstract

National audience; This paper proposes a new method for predicting traffic state within short time windows. This method takes advantage from space-partitioning, pattern extraction and Markov modelling. From trajectories, frequent regions are extracted where vehicles repeatedly pass through by using the frequent closed patterns and the traffic state is detected based on the evolution of these patterns over time. The next state of traffic for the frequent regions is then predicted based on the Markov models. Experiments on real-world data show that the proposed method is more accurate than a baseline method.; Cet article propose une nouvelle méthode de prédiction de l'état du trafic routier sur de courtes fenêtres temporelles. Cette méthode bénéficie des méthodes de partitionnement spatial, d'extraction de motifs et de modélisation Markovienne. À partir de trajectoires, nous extrayons des régions fréquentes où des véhicules passent de manière récurrente en utilisant les motifs fermés fré-quents et nous détectons l'état du trafic en se basant sur l'évolution des motifs dans le temps. Nous prédisons ensuite l'état suivant du trafic pour les régions fréquentes en se basant sur les chaînes de Markov. Les expérimentations effec-tuées sur des données réelles montrent que la méthode proposée est plus efficace qu'une méthode de base.

Published
2018

83. Effects of DEHP on post-embryonic development, nuclear receptor expression, metabolite and ecdysteroid concentrations of the moth Spodoptera littoralis

Author

Matthieu Dacher, Nicolas Durand, Isabelle Boulogne, David Siaussat, Amandine Aviles, Martine Maïbèche, Aurélie Goutte, Annick Maria, Alexandra Cordeiro, Françoise Bozzolan, David Renault, Fabrice Alliot, Institut d'écologie et des sciences de l'environnement de Paris (IEES (UMR_7618 / UMR_D_242 / UMR_A_1392 / UM_113) ), Institut National de la Recherche Agronomique (INRA)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Glycobiologie et Matrice Extracellulaire Végétale (Glyco-MEV), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols (METIS), École pratique des hautes études (EPHE)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), This work was supported by the French National Research Agency (ANR) [project endocrine Disruption of Insect Sexual Communication 2016–2019] and grant for INRA SPE department., ANR-14-CE21-0003,DISCO,Impact des perturbateurs endocriniens sur la communication sexuelle des insectes(2014), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2), and Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Health, Toxicology and Mutagenesis, 0208 environmental biotechnology, Gene Expression, Receptors, Cytoplasmic and Nuclear, Environmental pollution, 02 engineering and technology, 010501 environmental sciences, Endocrine Disruptors, 01 natural sciences, chemistry.chemical_compound, [SDV.BDD]Life Sciences [q-bio]/Development Biology, media_common, Larva, biology, Reproduction, Phthalate, Metamorphosis, Biological, Pupa, General Medicine, Pollution, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, medicine.medical_specialty, endocrine system, Environmental Engineering, media_common.quotation_subject, Spodoptera, Internal medicine, Diethylhexyl Phthalate, medicine, Environmental Chemistry, Animals, Metamorphosis, Spodoptera littoralis, 0105 earth and related environmental sciences, Bis(2-ethylhexyl) phthalate, Ecdysteroid, Bis(2-ethylhexyl)phthalate, fungi, Public Health, Environmental and Occupational Health, metabolic profiling, Ecdysteroids, General Chemistry, biology.organism_classification, 020801 environmental engineering, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Endocrinology, chemistry, insect, environmental pollution, Hormone
Abstract

International audience; Di (2-ethylhexyl) phthalate (DEHP) is recognized in vertebrates as an Endocrine Disrupting Chemical (EDC). DEHP can alter steroid hormones production, development, reproduction and behavior in vertebrates. Only few studies investigated DEHP effects on insects. However, some recent studies on aquatic insects showed that DEHP could also act as an EDC by interfering with the signaling pathways of ecdysteroids, the main hormones involved in the control of insect post-embryonic development and physiology. The aim of the study was to investigate (1) the fate of DEHP within a terrestrial insect species by exposing larvae to food containing a wide range of DEHP concentrations and (2) the effects of this chemical on their post-embryonic development and metamorphosis, by using a multi-level approach. DEHP was shown to be present both in larvae and resulting stages, with higher concentrations in chrysalises and adults than in larvae. DEHP concentrations also decreased at the end of the last larval instar, suggesting the metabolic transformation or excretion of this chemical during this time. Only the two highest DEHP doses induced higher insect mortality, whereas low and intermediate concentrations increased larval food consumption without affecting body weight. Metabolic profiles showed that in control insects, the last three days before metamorphosis correspond to a metabolic transition, but with time-dependent changes in treated insects. Interestingly, DEHP treatments also alter both hemolymphatic ecdysteroid titers and expression levels of ecdysteroid response genes. These results confirm that DEHP can alter insect post-embryonic development and metamorphosis, by interfering with ecdysteroid pathways.

Published
2018
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84. Changes in latitudinal sea surface temperature gradients along the Southern Chilean margin since the last glacial

Author

Catherine Kissel, Naoufel Haddam, Fabien Dewilde, Nadine Tisnérat-Laborde, Stéphanie Duchamp-Alphonse, Elisabeth Michel, Giuseppe Siani, Jérôme Kaiser, Jens Hefter, François Thil, Pascale Braconnot, Gulay Isguder, Frank Lamy, Nicolas Durand, Géosciences Paris Sud (GEOPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Paléocéanographie (PALEOCEAN), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), Modelling the Earth Response to Multiple Anthropogenic Interactions and Dynamics (MERMAID), Géochrononologie Traceurs Archéométrie (GEOTRAC), Laboratoire de mesure du carbone 14 (LMC14 - UMS 2572), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Climat et Magnétisme (CLIMAG), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

Subjects
Archeology, Global and Planetary Change, geography, Alkenone, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, Intertropical Convergence Zone, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Geology, 15. Life on land, 010502 geochemistry & geophysics, 01 natural sciences, Sea surface temperature, Oceanography, 13. Climate action, Deglaciation, 14. Life underwater, Glacial period, Ice sheet, Subtropical front, Ecology, Evolution, Behavior and Systematics, Holocene, 0105 earth and related environmental sciences
Abstract

International audience; The comparison between different climate model simulations of water hosing experiments under glacial conditions points toward diverging responses in Sea Surface Temperature changes (SST) especially in the Southeast Pacific (SEP). This suggests that reconstituting the latitudinal SST gradient in the SEP is a critical parameter for a better understanding of the mechanisms behind the abrupt climatic events since the last glacial period. Here we present, high-resolution records of SST, using planktonic foraminiferal assemblages and alkenone temperature reconstructions and stable oxygen and carbon isotopes from three deep-sea sediment cores along a latitudinal transect off the southern Chilean coast. This allowed us to reconstruct the variations of the latitudinal SST gradient and the Subtropical Front movements in the SEP. The SST results suggest a clear Antarctic timing consistent with the bipolar seesaw control, especially during the late glacial and the deglaciation. Our records do not suggest a complete oceanic heat transfer signal, highlighting the implication of an atmospheric component in the heat transfers between the two hemispheres, controlled by the latitudinal movements of the intertropical convergence zone in the Atlantic and the associated weaker South Pacific westerly split jet. Furthermore, our records indicate variable conditions during the Holocene, and also emphasize the influence of local fresh water inputs from the Patagonian ice sheet and/or precipitation on the SST fresh water input estimates along the Chilean margin (North and South of 49 degrees S) from the onset of the deglaciation until 8 kyr cal. BP. (C) 2018 Elsevier Ltd. All rights reserved.

Published
2018
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85. The insect HR38 nuclear receptor, a member of the NR4A subfamily, is a synchronizer of reproductive activity in a moth

Author

Edmundo Gassias, Elodie Demondion, Nicolas Durand, Stéphane Debernard, Thomas Bourgeois, Françoise Bozzolan, Universitat de Barcelona (UB), Institut d'écologie et des sciences de l'environnement de Paris (IEES), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Recherche Agronomique (INRA), Institut d'écologie et des sciences de l'environnement de Paris (IEES (UMR_7618 / UMR_D_242 / UMR_A_1392 / UM_113) ), Institut National de la Recherche Agronomique (INRA)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Institut d'écologie et des sciences de l'environnement de Paris (iEES), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris), and Institut National de la Recherche Agronomique (INRA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Male, media_common.quotation_subject, synchronisation, Receptors, Cytoplasmic and Nuclear, Agrotis ipsilon, chemical and pharmacologic phenomena, Insect, Moths, Biochemistry, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, 03 medical and health sciences, chemistry.chemical_compound, Sexual Behavior, Animal, parasitic diseases, sexual activity, Animals, Amino Acid Sequence, Mating, Sex Attractants, Receptor, Molecular Biology, media_common, fertility, Ecdysteroid, biology, Base Sequence, Reproduction, Cell Biology, biology.organism_classification, Cell biology, body regions, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, 030104 developmental biology, chemistry, Nuclear receptor, Gene Expression Regulation, Sex pheromone, NR4A nuclear receptor, Pheromone, insect, Female, Signal Transduction
Abstract

In the male moth, Agrotis ipsilon, the behavioural response and neuron sensitivity within the olfactory centres, the antennal lobes (ALs), to female sex pheromone increase with age, in correlation with the maturation of sex accessory glands (SAGs). By contrast, newly mated males cease to be attracted to sex pheromone and remate when their SAGs are refilled during the next night. The insect hormone receptor 38 (HR38), an ortholog of the vertebrate NR4A receptors, is a component of ecdysteroid signalling pathway which controls adult male physiology and behaviour. Here, we cloned the A. ipsilon HR38 (AiHR38) and explored its function in the coordination of reproductive events in the male. AiHR38 was detected in SAGs and ALs, and where its amount raised with age, in parallel with SAG protein content and sex pheromone responsiveness. By contrast, the AL and SAG AiHR38 expressions declined at 0-2 h after mating, in linking with depletion of SAG protein reserves and loss of sensitivity to sex pheromone. The increased AL and SAG AiHR38 expressions at 20-24 h postmating coincided with replenishing of SAGs and recovery of sensitivity to sex pheromone for a new mating. Moreover, AiHR38 knockdown resulted in reduction in SAG protein amount and disruption of sex pheromone-orientated flight. These results show that the insect HR38 is essential both for SAG activity, probably by controlling the protein synthesis, and display of male sexual behaviour, and that the concomitant regulation of its expression within SAGs and olfactory centres contributes to synchronisation between fertility and sexual activity. DATABASE: The nucleotide sequence of Agrotis ipsilon HR38 is available in the DDBJ/EMBL/GenBank databases under the accession number MF402845.

Published
2018
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86. List of Contributors

Author

W. Paul Adderley, José Aguilar, Octavio Artieda, Maria Bronnikova, Matthew G. Canti, Marie-Agnès Courty, Mauro Cremaschi, Donald A. Davidson, Yannick Devos, Nicolas Durand, William R. Effland, Nicolas Fedoroff, Catherine A. Fox, Maria Gerasimova, Paul Goldberg, Zhengtang Guo, Ma. del Carmen Gutiérrez-Castorena, Kristin Ismail-Meyer, Danuta Kaczorek, Panagiotis Karkanas, Maja J. Kooistra, Irina Kovda, Peter Kühn, Frans Kwaad, Marina Lebedeva, David L. Lindbo, Richard I. Macphail, Vera Marcelino, Florias Mees, Ahmet R. Mermut, Rienk Miedema, H. Curtis Monger, Herman Mücher, Marcello Pagliai, Ákos Petó, Rosa M. Poch, Mirjam M. Pulleman, Dominique Righi, Carlos E.G.R. Schaefer, Sergey Sedov, Sergei Shoba, Felipe N.B. Simas, Ian A. Simpson, Mark H. Stolt, Georges Stoops, Luca Trombino, Tatiana V. Tursina, Eric Van Ranst, Henk van Steijn, Brigitte Van Vliet-Lanoë, Michael J. Vepraskas, Eric P. Verrecchia, Luc Vrydaghs, Amanda J. Williams, Clare A. Wilson, Michael A. Wilson, Siti Zauyah, and Andrea Zerboni

Published
2018
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87. Calcium Carbonate Features

Author

Nicolas Durand, H. Curtis Monger, Matthew G. Canti, and Eric P. Verrecchia

Subjects
010504 meteorology & atmospheric sciences, 010502 geochemistry & geophysics, 01 natural sciences, 0105 earth and related environmental sciences
Published
2018
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88. Glutathione-s-transferases in the olfactory organ of the noctuid moth spodoptera littoralis, diversity and conservation of chemosensory clades

Author

David Siaussat, Nicolas Durand, Françoise Bozzolan, Martine Maïbèche, Marie-Anne Pottier, Thomas Chertemps, Institut d'écologie et des sciences de l'environnement de Paris (iEES), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Recherche Agronomique (INRA), and Chertemps, Thomas

Subjects
0301 basic medicine, Signal peptide, Olfactory system, Physiology, media_common.quotation_subject, [SDV]Life Sciences [q-bio], Olfaction, Insect, Biology, lcsh:Physiology, 03 medical and health sciences, Physiology (medical), GST (glutathione S transferase), Spodoptera littoralis, olfaction, detoxification, odorant degrading enzyme, Clade, Gene, media_common, lcsh:QP1-981, Phylogenetic tree, fungi, biology.organism_classification, 030104 developmental biology, Evolutionary biology, [SDE]Environmental Sciences
Abstract

International audience; Glutathione-S-transferases (GSTs) are conjugating enzymes involved in the detoxification of a wide range of xenobiotic compounds. The expression of GSTs as well as their activities have been also highlighted in the olfactory organs of several species, including insects, where they could play a role in the signal termination and in odorant clearance. Using a transcriptomic approach, we identified 33 putative GSTs expressed in the antennae of the cotton leafworm Spodoptera littoralis. We established their expression patterns and revealed four olfactory-enriched genes in adults. In order to investigate the evolution of antennal GST repertoires in moths, we re-annotated antennal transcripts corresponding to GSTs in two moth and one coleopteran species. We performed a large phylogenetic analysis that revealed an unsuspected structural-and potentially functional-diversity of GSTs within the olfactory organ of insects. This led us to identify a conserved clade containingmost of the already identified antennal-specific and antennal-enriched GSTs from moths. In addition, for all the sequences from this clade, we were able to identify a signal peptide, which is an unusual structural feature for GSTs. Taken together, these data highlight the diversity and evolution of GSTs in the olfactory organ of a pest species and more generally in the olfactory system of moths, and also the conservation of putative extracellular members across multiple insect orders.

Published
2018
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89. Classification orientée perceptions

Author

Mohamed Quafafou, Nicolas Durand, Data Mining at scale (DANA), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), DURAND, Nicolas, and Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], [SCCO.COMP] Cognitive science/Computer science, [SCCO.COMP]Cognitive science/Computer science, [INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Classer un objet quelconque revient à examiner ses caractéristiques et lui attribuer une classe qui est une valeur discrète appartenant au domaine d'un attribut donné. Cependant, pour examiner une caractéristique il faudra d'abord la percevoir et cette perception dépend de l'observateur de l'objet (machine ou humain). La question est alors : comment faire de la classification en présence de multiples observateurs ayant des perceptions différentes de l'univers ? Cette question est fondamentale car même en faisant appel à des experts d'un domaine particulier pour classer, chacun de son côté des cas d'études, alors on n'obtient pas forcément la même classification. Nous étudions ce problème de classification intégrant la perception dans le cadre de la théorie des ensembles accessibles en le formalisant et en déclinant quelques solutions possibles. Ainsi, le problème de la classification orientée perceptions se réduit au problème de classification classique lorsque tous les observateurs ont la même perception de l'univers.

Published
2017

90. Équilibration de la douleur en soins palliatifs chez un patient atteint de cancer par une analgésie autocontrôlée par méthadone : une alternative possible à la prise de doses fixes

Author

Patricia Monplaisi, Nicolas Durand de Grossouvre, Philippe Poulain, and Nathalie Laffargue

Subjects
Anesthesiology and Pain Medicine, Neurology (clinical)
Abstract

Resume La methadone est utilisee dans de nombreux pays comme traitement antalgique des douleurs liees au cancer. Nous rapportons le cas d’un patient ayant bien repondu a la methode d’analgesie autocontrolee preconisee comme methode d’equilibration par le protocole de l’Afssaps 2010.

Published
2014
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91. Antennal uridine diphosphate (UDP)-glycosyltransferases in a pest insect: diversity and putative function in odorant and xenobiotics clearance

Author

Annick Maria, Thomas Chertemps, Martine Maïbèche-Coisne, David Siaussat, Marie-Anne Pottier, Françoise Bozzolan, and Nicolas Durand

Subjects
Olfactory system, media_common.quotation_subject, fungi, Insect, Olfaction, Biology, biology.organism_classification, digestive system, Transcriptome, Olfactory mucosa, Uridine diphosphate, chemistry.chemical_compound, medicine.anatomical_structure, Biochemistry, chemistry, Insect Science, Botany, Genetics, medicine, Spodoptera littoralis, Molecular Biology, Gene, media_common
Abstract

Uridine diphosphate UDP-glycosyltransferases (UGTs) are detoxification enzymes widely distributed within living organisms. They are involved in the biotransformation of various lipophilic endogenous compounds and xenobiotics, including odorants. Several UGTs have been reported in the olfactory organs of mammals and involved in olfactory processing and detoxification within the olfactory mucosa but, in insects, this enzyme family is still poorly studied. Despite recent transcriptomic analyses, the diversity of antennal UGTs in insects has not been investigated. To date, only three UGT cDNAs have been shown to be expressed in insect olfactory organs. In the present study, we report the identification of eleven putative UGTs expressed in the antennae of the model pest insect Spodoptera littoralis. Phylogenetic analysis revealed that these UGTs belong to five different families, highlighting their structural diversity. In addition, two genes, UGT40R3 and UGT46A6, were either specifically expressed or overexpressed in the antennae, suggesting specific roles in this sensory organ. Exposure of male moths to the sex pheromone and to a plant odorant differentially downregulated the transcription levels of these two genes, revealing for the first time the regulation of insect UGTs by odorant exposure. Moreover, the specific antennal gene UGT46A6 was upregulated by insecticide topical application on antennae, suggesting its role in the protection of the olfactory organ towards xenobiotics. This work highlights the structural and functional diversity of UGTs within this highly specialized tissue.

Published
2014
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92. Metaheuristics for Air Traffic Management

Author

Nicolas Durand, David Gianazza, Jean-Baptiste Gotteland, Jean-Marc Alliot, Nicolas Durand, David Gianazza, Jean-Baptiste Gotteland, and Jean-Marc Alliot

Subjects
Air traffic control, Mathematical optimization, Heuristic programming
Abstract

Air Traffic Management involves many different services such as Airspace Management, Air Traffic Flow Management and Air Traffic Control. Many optimization problems arise from these topics and they generally involve different kinds of variables, constraints, uncertainties. Metaheuristics are often good candidates to solve these problems. The book models various complex Air Traffic Management problems such as airport taxiing, departure slot allocation, en route conflict resolution, airspace and route design. The authors detail the operational context and state of art for each problem. They introduce different approaches using metaheuristics to solve these problems and when possible, compare their performances to existing approaches

Published
2016

93. Aircraft deconfliction with speed regulation: new models from mixed-integer optimization

Author

Nicolas Durand, Sonia Cafieri, ENAC - Laboratoire de Mathématiques Appliquées, Informatique et Automatique pour l'Aérien (MAIAA), Ecole Nationale de l'Aviation Civile (ENAC), and ANR-12-JS02-0009,ATOMIC,Optimisation du trafic aérien via des méthodes mixtes (discretes-continus)(2012)

Subjects
MINLP, Mathematical optimization, Control and Optimization, Heuristic (computer science), 0211 other engineering and technologies, 02 engineering and technology, Management Science and Operations Research, Conflict avoidance, air traffic management, 0502 economics and business, Global optimality, global exact solution, Mathematics, conflict avoidance, 050210 logistics & transportation, 021103 operations research, Applied Mathematics, 05 social sciences, Air traffic management, modeling, Solver, Computer Science Applications, heuristic, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Heuristic procedure, Focus (optics), Integer (computer science)
Abstract

International audience; Detecting and solving aircraft conflicts, which occur when aircraft sharing the same airspace are too close to each other according to their predicted trajectories, is a crucial problem in Air Traffic Management. We focus on mixed-integer optimization models based on speed regulation. We first solve the problem to global optimality by means of an exact solver. The problem being very difficult to solve, we also propose a heuristic procedure where the problem is decomposed and it is locally exactly solved. Computational results show that the proposed approach provides satisfactory results.

Published
2013
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94. Comparison of 14C and U-Th Ages in Corals from IODP #310 Cores Offshore Tahiti

Author

Edouard Bard, Nicolas Durand, Gideon M. Henderson, Alexander L. Thomas, Gilbert Camoin, Pierre Deschamps, Yusuke Yokoyama, Bruno Hamelin, and Hiroyuki Matsuzaki

Subjects
010506 paleontology, Archeology, geography, Plateau, geography.geographical_feature_category, 060102 archaeology, Drilling, 06 humanities and the arts, 01 natural sciences, Carbon cycle, law.invention, Oceanography, 13. Climate action, Time windows, law, Period (geology), Deglaciation, General Earth and Planetary Sciences, 0601 history and archaeology, Submarine pipeline, 14. Life underwater, Radiocarbon dating, Geology, 0105 earth and related environmental sciences
Abstract

Shallow-water tropical corals can be used to calibrate the radiocarbon timescale. In this paper, we present a new data set based on the comparison between 14C ages and U-Th ages measured in fossil corals collected offshore the island of Tahiti during the Integrated Oceanic Drilling Program (IODP) Expedition 310. After applying strict mineralogical and geochemical screening criteria, the Tahiti record provides new data for 2 distinct time windows: 7 data for the interval between 29 and 37 cal kyr BP and 58 for the last deglaciation period, notably a higher resolution for the 14–16 cal kyr BP time interval. There are 3 main outcomes of this study. First, it extends the previous Tahiti record beyond 13.9 cal kyr BP, the oldest U-Th age obtained on cores drilled onshore in the modern Tahiti barrier reef. Second, it strengthens the data set of the 14–15 cal kyr BP period, allowing for better documentation of the 14C age plateau in this time range. This age plateau corresponds to a drop of the atmospheric 14C synchronous with an abrupt period of sea-level rise (Melt Water Pulse 1 A, MWP-1 A). The Tahiti 14C record documents complex changes in the global carbon cycle due to variations in the exchange rates between its different reservoirs. Third, during the Heinrich event 1, the Tahiti record disagrees with the Cariaco record, but is in broad agreement with other marine and continental data.

Published
2013
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95. Integration of UAS in Terminal Control Area

Author

Nicolas Barnier, Eric Blond, Guido Manfredi, Nicolas Durand, Cyril Allignol, Ecole Nationale de l'Aviation Civile (ENAC), Direction de la technique et de l'innovation de la DGAC (DTI), and Direction Générale de l'Aviation Civile (DGAC)

Subjects
0209 industrial biotechnology, Engineering, Heading (navigation), business.industry, Separation (aeronautics), Context (language use), 02 engineering and technology, 020901 industrial engineering & automation, Detect and avoid, Robustness (computer science), 0202 electrical engineering, electronic engineering, information engineering, Trajectory, Commercial aviation, 020201 artificial intelligence & image processing, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], business, Terminal control area, Simulation
Abstract

International audience; In this article, we test a horizontal detect and avoid algorithm for UASs flying in Terminal Control Areas. We have used recorded commercial traffic trajectories and randomly built thousands of conflict scenarios with UASs to check the ability of such an algorithm to ensure the separation with commercial aviation. We consider two different types of UASs, flying at 80kn or 160kn, with six different missions: flying straight or turning and leveled, climbing or descending. We only focus on horizontal maneuvers at constant speed in order to not interfere with the TCASs of aircraft, nor rely on most UASs poor ability to change speed. The article investigates the influence of the various parameters on the separation achieved and the amount of maneuvers required, especially the strategy used to select the best maneuver among the allowed headings. The analysis of our results shows that, amid two basic and “extreme” strategies that favor either minimal heading changes or the robustness of the maneuvers, the combination of both, switching from the first one to the second whenever the distance between the UAS and aircraft falls under a given threshold, gives the best results with very few remaining airproxes, while keeping low the amount and amplitude of maneuvers.

Published
2016
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96. Assessing subsidence rates and paleo water-depths for Tahiti reefs using U-Th chronology of altered corals

Author

Yasunari Takahashi, Nicolas Durand, Terry Quinn, Alexander L. Thomas, Gilbert Camoin, Edouard Bard, Andrew J. Mason, Katrin Heindel, Akitoshi Omori, Hiroki Matsuda, Tokiyuki Sato, Saburo Sakai, Lucie Menabreaz, Alexander W. Tudhope, Kazuhiko Fujita, Yusuke Yokoyama, Bruno Hamelin, Jody M. Webster, Hildegard Westphal, Pierre Deschamps, Guy Cabioch, Julia E. Cole, Kaoru Sugihara, Yasufumi Iryu, Nicolas Thouveny, Gideon M. Henderson, Department of Earth Sciences, University of Oxford, University of Oxford [Oxford], Department of Physics and Earth Sciences, University of the Ryukyus [Okinawa], Institute of Geology and Paleontology, Tohoku University [Sendai], Chaire Evolution du climat et de l'océan, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Paléoclimats, proxies, processus (PALEOPROXUS), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Geosciences, University of Arizona, University of Arizona, Center for Marine Environmental Sciences [Bremen] (MARUM), Universität Bremen, Department of Earth and Environmental Science [Kumamoto], Kumamoto University, Institute of Geosciences [Shizuoka], University of Shizuoka, College of Marine Science [Florida], University of South Florida [Tampa] (USF), Institute for Research on Earth Evolution [Yokosuka] (IFREE), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Department of Earth System Science [Fukuoka], Fukuoka University, School of Geosciences [Edinburgh], University of Edinburgh, The University of Sydney, James Cook University (JCU), Atmosphere and Ocean Research Institute [Kashiwa-shi] (AORI), The University of Tokyo (UTokyo), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), Department of Earth and Environmental Sciences [Kumamoto], University of South Florida (USF), The University of Tokyo, Department of Earth Sciences [Oxford], University of Oxford, Collège de France - Chaire Evolution du climat et de l'océan, Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Department of Geosciences [University of Arizona], and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Marine isotope stage, 010504 meteorology & atmospheric sciences, Pleistocene, Marine geology and geophysics, Coral, PLEISTOCENE, [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], PALEOENVIRONNEMENT, U–Th, 010502 geochemistry & geophysics, Oceanography, 01 natural sciences, Paleontology, paleo water-depth, Geochemistry and Petrology, IODP Expedition 310, 14. Life underwater, Reef, coral, Sea level, island subsidence, 0105 earth and related environmental sciences, geography, geography.geographical_feature_category, ALTERATION, Geology, CORAIL, Diagenesis, Earth sciences, Geochemistry, NIVEAU MARIN, Facies, open system, Tahiti, CHRONOLOGIE, Chronology
Abstract

International audience; We present uranium–thorium chronology for a 102 m core through a Pleistocene reef at Tahiti (French Polynesia) sampled during IODP Expedition 310 “Tahiti Sea Level”. We employ total and partial dissolution procedures on the older coral samples to investigate the diagenetic overprint of the uranium–thorium system. Although alteration of the U–Th system cannot be robustly corrected, diagenetic trends in the U–Th data, combined with sea level and subsidence constraints for the growth of the corals enables the age of critical samples to be constrained to marine isotope stage 9. We use the ages of the corals, together with δ18O based sea-level histories, to provide maximum constraints on possible paleo water-depths. These depth constraints are then compared to independent depth estimates based on algal and foraminiferal assemblages, microbioerosion patterns, and sedimentary facies, confirming the accuracy of these paleo water-depth estimates. We also use the fact that corals could not have grown above sea level to place a maximum constraint on the subsidence rate of Tahiti to be 0.39 m ka−1, with the most likely rate being close to the existing minimum estimate of 0.25 m ka−1.

Published
2016
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97. Frequent Itemset Border Approximation by Dualization

Author

Nicolas Durand, Mohamed Quafafou, Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS), and DURAND, Nicolas

Subjects
Discrete mathematics, Hypergraph, Reduction (recursion theory), Computation, 02 engineering and technology, Function (mathematics), borders, [INFO] Computer Science [cs], dualization, hypergraph transversals, Combinatorics, frequent itemsets, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Point (geometry), [INFO]Computer Science [cs], Hypergraph transversals, approximation, Mathematics
Abstract

The approach FIBAD is introduced with the purpose of computing approximate borders of frequent itemsets by leveraging dualization and computation of approximate minimal transversals of hypergraphs. The distinctiveness of the FIBAD's theoretical foundations is the approximate dualization where a new function $$\widetilde{f}$$ is defined to compute the approximate negative border. From a methodological point of view, the function $$\widetilde{f}$$ is implemented by the method AMTHR that consists of a reduction of the hypergraph and a computation of its minimal transversals. For evaluation purposes, we study the sensibility of FIBAD to AMTHR by replacing this latter by two other algorithms that compute approximate minimal transversals. We also compare our approximate dualization-based method with an existing approach that computes directly, without dualization, the approximate borders. The experimental results show that our method outperforms the other methods as it produces borders that have the highest quality.

Published
2016

98. Semantic Pattern Mining Based Web Service Recommendation

Author

Mohamed Quafafou, Nicolas Durand, Mustapha Aznag, Hafida Naim, DURAND, Nicolas, Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS)

Subjects
Topic model, Topic models, Process (engineering), Computer science, Computation, Formal concept analysis, Probabilistic logic, 02 engineering and technology, Recommendation, [INFO] Computer Science [cs], Recommender system, computer.software_genre, Maximal frequent itemsets, 020204 information systems, Semantic computing, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], 020201 artificial intelligence & image processing, Data mining, Web service, computer, Concept lattice, Web services
Abstract

International audience; This paper deals with the problem of web service recommendation. We propose a new content-based recommendation system. Its originality comes from the combination of probabilistic topic models and pattern mining to capture the maximal common semantic of sets of services. We define the notion of semantic patterns which are maximal frequent itemsets of topics. In the off-line process, the computation of these patterns is performed by using frequent concept lattices in order to find also the sets of services associated to the semantic patterns. These sets of services are then used to recommend services in the on-line process. We compare the results of the proposed system in terms of precision and normalized discounted cumulative gain with Apache Lucene and SAWSDL-MX2 Matchmaker on real-world data. Our proposition outperforms these two systems.

Published
2016
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99. Probabilistic Approach for Diversifying Web Services Discovery and Composition

Author

Mustapha Aznag, Mohamed Quafafou, Hafida Naim, Nicolas Durand, Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS), DURAND, Nicolas, and Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU)

Subjects
Web standards, medicine.medical_specialty, Topic Models, Computer science, Formal Concept Analysis, Service discovery, Services computing, 02 engineering and technology, [INFO] Computer Science [cs], computer.software_genre, World Wide Web, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, medicine, [INFO]Computer Science [cs], Web services, WS-Addressing, Diversity, 020207 software engineering, Discovery and ranking, Web Services Discovery, Service Dependency Network, Web service, WS-Policy, computer, Web modeling, Composition
Abstract

International audience; Due to the increasing number of available web services, discovering the best service that matches a user requirement is still a challenge. In most cases the discovery system returns a set of very similar services and sometimes it is unable to find results for some complex queries. Therefore, integrating web service discovery and composition, taking into account the diversity of discovered results, in a unified way is still a big issue for web services. In this paper, we propose a novel service ranking algorithm for diversifying web services discovery results in order to minimize the redundancy in the search results. This algorithm chooses a set of selected web services based on relevancy, service diversity and service density. We also propose a new method to generate service dependency network using the Formal Concept Analysis (FCA) framework. The generated graph is used to select the composition of discovered web services set. Experimental results show that our method performs better than others baseline approaches.

Published
2016

100. Semantic Divergence based Evaluation of Web Service Communities

Author

Mustapha Aznag, Hafida Naim, Mohamed Quafafou, Nicolas Durand, DURAND, Nicolas, Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS)

Subjects
Topic model, Computer science, Topic models, [INFO] Computer Science [cs], computer.software_genre, Machine learning, 01 natural sciences, Social Semantic Web, 010305 fluids & plasmas, Semantic divergence, 0103 physical sciences, [INFO]Computer Science [cs], 010306 general physics, Divergence (statistics), Web services, Community detection algorithms, business.industry, Rank (computer programming), Probabilistic logic, Dependency network, Ranking, Data mining, Artificial intelligence, Web service, business, Service communities, computer
Abstract

International audience; The number of community detection algorithms is growing continuously adopting a topological based approach to discover optimal subgraphs or communities. In this paper, we propose a new method combining both topology and semantic to evaluate and rank community detection algorithms. To achieve this goal we consider a probabilistic topic based approach to define a new measure called semantic divergence of communities. Combining this measure with others related to prior knowledge, we compute a score for each algorithm to evaluate the effectiveness of its communities and propose a ranking method. We have evaluated our approach considering communities of real web services.

Published
2016

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