5,778 results on '"Nicolas B"'
Search Results
52. New Mass and Radius Constraints on the LHS 1140 Planets -- LHS 1140 b is Either a Temperate Mini-Neptune or a Water World
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Cadieux, Charles, Plotnykov, Mykhaylo, Doyon, René, Valencia, Diana, Jahandar, Farbod, Dang, Lisa, Turbet, Martin, Fauchez, Thomas J., Cloutier, Ryan, Cherubim, Collin, Artigau, Étienne, Cook, Neil J., Edwards, Billy, Hallatt, Tim, Charnay, Benjamin, Bouchy, François, Allart, Romain, Mignon, Lucile, Baron, Frédérique, Barros, Susana C. C., Benneke, Björn, Martins, B. L. Canto, Cowan, Nicolas B., De Medeiros, J. R., Delfosse, Xavier, Delgado-Mena, Elisa, Dumusque, Xavier, Ehrenreich, David, Hara, Nathan C., Lafrenière, David, Frensch, Yolanda G. C., Hernández, J. I. González, Curto, Gaspare Lo, Malo, Lison, Melo, Claudio, Mounzer, Dany, Passeger, Vera Maria, Pepe, Francesco, Poulin-Girard, Anne-Sophie, Santos, Nuno C., Sosnowska, Danuta, Mascareño, Alejandro Suárez, Thibault, Simon, Vaulato, Valentina, Wade, Gregg A., and Wildi, François
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The two-planet transiting system LHS 1140 has been extensively observed since its discovery in 2017, notably with $Spitzer$, HST, TESS, and ESPRESSO, placing strong constraints on the parameters of the M4.5 host star and its small temperate exoplanets, LHS 1140 b and c. Here, we reanalyse the ESPRESSO observations of LHS 1140 with the novel line-by-line framework designed to fully exploit the radial velocity content of a stellar spectrum while being resilient to outlier measurements. The improved radial velocities, combined with updated stellar parameters, consolidate our knowledge on the mass of LHS 1140 b (5.60$\pm$0.19 M$_{\oplus}$) and LHS 1140 c (1.91$\pm$0.06 M$_{\oplus}$) with unprecedented precision of 3%. Transits from $Spitzer$, HST, and TESS are jointly analysed for the first time, allowing us to refine the planetary radii of b (1.730$\pm$0.025 R$_{\oplus}$) and c (1.272$\pm$0.026 R$_{\oplus}$). Stellar abundance measurements of refractory elements (Fe, Mg and Si) obtained with NIRPS are used to constrain the internal structure of LHS 1140 b. This planet is unlikely to be a rocky super-Earth as previously reported, but rather a mini-Neptune with a $\sim$0.1% H/He envelope by mass or a water world with a water-mass fraction between 9 and 19% depending on the atmospheric composition and relative abundance of Fe and Mg. While the mini-Neptune case would not be habitable, a water-abundant LHS 1140 b potentially has habitable surface conditions according to 3D global climate models, suggesting liquid water at the substellar point for atmospheres with relatively low CO$_2$ concentration, from Earth-like to a few bars., Comment: 31 pages, 18 figures, accepted for publication in ApJL
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- 2023
53. Near-Infrared Transmission Spectroscopy of HAT-P-18$\,$b with NIRISS: Disentangling Planetary and Stellar Features in the Era of JWST
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Fournier-Tondreau, Marylou, MacDonald, Ryan J., Radica, Michael, Lafrenière, David, Welbanks, Luis, Piaulet, Caroline, Coulombe, Louis-Philippe, Allart, Romain, Morel, Kim, Artigau, Étienne, Albert, Loïc, Lim, Olivia, Doyon, René, Benneke, Björn, Rowe, Jason F., Darveau-Bernier, Antoine, Cowan, Nicolas B., Lewis, Nikole K., Cook, Neil James, Flagg, Laura, Genest, Frédéric, Pelletier, Stefan, Johnstone, Doug, Dang, Lisa, Kaltenegger, Lisa, Taylor, Jake, and Turner, Jake D.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The JWST Early Release Observations (ERO) included a NIRISS/SOSS (0.6-2.8$\,\mu$m) transit of the $\sim\,$850$\,$K Saturn-mass exoplanet HAT-P-18$\,$b. Initial analysis of these data reported detections of water, escaping helium, and haze. However, active K dwarfs like HAT-P-18 possess surface heterogeneities $-$ starspots and faculae $-$ that can complicate the interpretation of transmission spectra, and indeed, a spot-crossing event is present in HAT-P-18$\,$b's NIRISS/SOSS light curves. Here, we present an extensive reanalysis and interpretation of the JWST ERO transmission spectrum of HAT-P-18$\,$b, as well as HST/WFC3 and $\textit{Spitzer}$/IRAC transit observations. We detect H$_2$O (12.5$\,\sigma$), CO$_2$ (7.3$\,\sigma$), a cloud deck (7.4$\,\sigma$), and unocculted starspots (5.8$\,\sigma$), alongside hints of Na (2.7$\,\sigma$). We do not detect the previously reported CH$_4$ ($\log$ CH$_4$ $<$ -6 to 2$\,\sigma$). We obtain excellent agreement between three independent retrieval codes, which find a sub-solar H$_2$O abundance ($\log$ H$_2$O $\approx -4.4 \pm 0.3$). However, the inferred CO$_2$ abundance ($\log$ CO$_2$ $\approx -4.8 \pm 0.4$) is significantly super-solar and requires further investigation into its origin. We also introduce new stellar heterogeneity considerations by fitting for the active regions' surface gravities $-$ a proxy for the effects of magnetic pressure. Finally, we compare our JWST inferences to those from HST/WFC3 and $\textit{Spitzer}$/IRAC. Our results highlight the exceptional promise of simultaneous planetary atmosphere and stellar heterogeneity constraints in the era of JWST and demonstrate that JWST transmission spectra may warrant more complex treatments of the transit light source effect.
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- 2023
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54. Characterizing the Near-infrared Spectra of Flares from TRAPPIST-1 During JWST Transit Spectroscopy Observations
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Howard, Ward S., Kowalski, Adam F., Flagg, Laura, MacGregor, Meredith A., Lim, Olivia, Radica, Michael, Piaulet, Caroline, Roy, Pierre-Alexis, Lafrenière, David, Benneke, Björn, Brown, Alexander, Espinoza, Néstor, Doyon, René, Coulombe, Louis-Philippe, Johnstone, Doug, Cowan, Nicolas B., Jayawardhana, Ray, Turner, Jake D., and Dang, Lisa
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present the first analysis of JWST near-infrared spectroscopy of stellar flares from TRAPPIST-1 during transits of rocky exoplanets. Four flares were observed from 0.6--2.8 $\mu$m with NIRISS and 0.6--3.5 $\mu$m with NIRSpec during transits of TRAPPIST-1b, f, and g. We discover P$\alpha$ and Br$\beta$ line emission and characterize flare continuum at wavelengths from 1--3.5 $\mu$m for the first time. Observed lines include H$\alpha$, P$\alpha$-P$\epsilon$, Br$\beta$, He I $\lambda$0.7062$\mu$m, two Ca II infrared triplet (IRT) lines, and the He I IRT. We observe a reversed Paschen decrement from P$\alpha$-P$\gamma$ alongside changes in the light curve shapes of these lines. The continuum of all four flares is well-described by blackbody emission with an effective temperature below 5300 K, lower than temperatures typically observed at optical wavelengths. The 0.6--1 $\mu$m spectra were convolved with the TESS response, enabling us to measure the flare rate of TRAPPIST-1 in the TESS bandpass. We find flares of 10$^{30}$ erg large enough to impact transit spectra occur at a rate of 3.6$\substack{+2.1 \\ -1.3}$ flare d$^{-1}$, $\sim$10$\times$ higher than previous predictions from K2. We measure the amount of flare contamination at 2 $\mu$m for the TRAPPIST-1b and f transits to be 500$\pm$450 and 2100$\pm$400 ppm, respectively. We find up to 80% of flare contamination can be removed, with mitigation most effective from 1.0--2.4 $\mu$m. These results suggest transits affected by flares may still be useful for atmospheric characterization efforts., Comment: 29 pages, 17 figures, 3 tables, accepted to The Astrophysical Journal
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- 2023
55. Super-Earth LHS3844b is tidally locked
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Lyu, Xintong, Koll, Daniel D. B., Cowan, Nicolas B., Hu, Renyu, Kreidberg, Laura, and Rose, Brain E. J.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Short period exoplanets on circular orbits are thought to be tidally locked into synchronous rotation. If tidally locked, these planets must possess permanent day- and nightsides, with extreme irradiation on the dayside and none on the nightside. However, so far the tidal locking hypothesis for exoplanets is supported by little to no empirical evidence. Previous work showed that the super-Earth LHS 3844b likely has no atmosphere, which makes it ideal for constraining the planet's rotation. Here we revisit the Spitzer phase curve of LHS 3844b with a thermal model of an atmosphere-less planet and analyze the impact of non-synchronous rotation, eccentricity, tidal dissipation, and surface composition. Based on the lack of observed strong tidal heating we rule out rapid non-synchronous rotation (including a Mercury-like 3:2 spin-orbit resonance) and constrain the planet's eccentricity to less than 0.001 (more circular than Io's orbit). In addition, LHS 3844b's phase curve implies that the planet either still experiences weak tidal heating via a small-but-nonzero eccentricity (requiring an undetected orbital companion), or that its surface has been darkened by space weathering; of these two scenarios we consider space weathering more likely. Our results thus support the hypothesis that short period rocky exoplanets are tidally locked, and further show that space weathering can significantly modify the surfaces of atmosphere-less exoplanets., Comment: Accepted
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- 2023
56. Atmospheric Reconnaissance of TRAPPIST-1 b with JWST/NIRISS: Evidence for Strong Stellar Contamination in the Transmission Spectra
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Lim, Olivia, Benneke, Björn, Doyon, René, MacDonald, Ryan J., Piaulet, Caroline, Artigau, Étienne, Coulombe, Louis-Philippe, Radica, Michael, L'Heureux, Alexandrine, Albert, Loïc, Rackham, Benjamin V., de Wit, Julien, Salhi, Salma, Roy, Pierre-Alexis, Flagg, Laura, Fournier-Tondreau, Marylou, Taylor, Jake, Cook, Neil J., Lafrenière, David, Cowan, Nicolas B., Kaltenegger, Lisa, Rowe, Jason F., Espinoza, Néstor, Dang, Lisa, and Darveau-Bernier, Antoine
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
TRAPPIST-1 is a nearby system of seven Earth-sized, temperate, rocky exoplanets transiting a Jupiter-sized M8.5V star, ideally suited for in-depth atmospheric studies. Each TRAPPIST-1 planet has been observed in transmission both from space and from the ground, confidently rejecting cloud-free, hydrogen-rich atmospheres. Secondary eclipse observations of TRAPPIST-1 b with JWST/MIRI are consistent with little to no atmosphere given the lack of heat redistribution. Here we present the first transmission spectra of TRAPPIST-1 b obtained with JWST/NIRISS over two visits. The two transmission spectra show moderate to strong evidence of contamination from unocculted stellar heterogeneities, which dominates the signal in both visits. The transmission spectrum of the first visit is consistent with unocculted starspots and the second visit exhibits signatures of unocculted faculae. Fitting the stellar contamination and planetary atmosphere either sequentially or simultaneously, we confirm the absence of cloud-free hydrogen-rich atmospheres, but cannot assess the presence of secondary atmospheres. We find that the uncertainties associated with the lack of stellar model fidelity are one order of magnitude above the observation precision of 89 ppm (combining the two visits). Without affecting the conclusion regarding the atmosphere of TRAPPIST-1 b, this highlights an important caveat for future explorations, which calls for additional observations to characterize stellar heterogeneities empirically and/or theoretical works to improve model fidelity for such cool stars. This need is all the more justified as stellar contamination can affect the search for atmospheres around the outer, cooler TRAPPIST-1 planets for which transmission spectroscopy is currently the most efficient technique., Comment: 26 pages, 11 figures, accepted for publication in The Astrophysical Journal Letters
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- 2023
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57. Integrated photonic-based coronagraphic systems for future space telescopes
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Desai, Niyati, König, Lorenzo, Por, Emiel, Juanola-Parramon, Roser, Belikov, Ruslan, Laginja, Iva, Guyon, Olivier, Pueyo, Laurent, Fogarty, Kevin, Absil, Olivier, Altinier, Lisa, Baudoz, Pierre, Bidot, Alexis, Bonse, Markus Johannes, Bott, Kimberly, Brandl, Bernhard, Carlotti, Alexis, Casewell, Sarah L., Choquet, Elodie, Cowan, Nicolas B., Doelman, David, Fowler, J., Gebhard, Timothy D., Gutierrez, Yann, Haffert, Sebastiaan Y., Herscovici-Schiller, Olivier, Hours, Adrien, Kenworthy, Matthew, Kleisioti, Elina, Krasteva, Mariya, Landman, Rico, Leboulleux, Lucie, Mazoyer, Johan, Millar-Blanchaer, Maxwell A., Mouillet, David, NDiaye, Mamadou, Snik, Frans, van Dam, Dirk, van Gorkom, Kyle, van Kooten, Maaike, and Vaughan, Sophia R.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The detection and characterization of Earth-like exoplanets around Sun-like stars is a primary science motivation for the Habitable Worlds Observatory. However, the current best technology is not yet advanced enough to reach the 10^-10 contrasts at close angular separations and at the same time remain insensitive to low-order aberrations, as would be required to achieve high-contrast imaging of exo-Earths. Photonic technologies could fill this gap, potentially doubling exo-Earth yield. We review current work on photonic coronagraphs and investigate the potential of hybridized designs which combine both classical coronagraph designs and photonic technologies into a single optical system. We present two possible systems. First, a hybrid solution which splits the field of view spatially such that the photonics handle light within the inner working angle and a conventional coronagraph that suppresses starlight outside it. Second, a hybrid solution where the conventional coronagraph and photonics operate in series, complementing each other and thereby loosening requirements on each subsystem. As photonic technologies continue to advance, a hybrid or fully photonic coronagraph holds great potential for future exoplanet imaging from space., Comment: Conference Proceedings of SPIE: Techniques and Instrumentation for Detection of Exoplanets XI, vol. 12680 (2023)
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- 2023
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58. Visible extreme adaptive optics on extremely large telescopes: Towards detecting oxygen in Proxima Centauri b and analogs
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Fowler, J., Haffert, Sebastiaan Y., van Kooten, Maaike A. M., Landman, Rico, Bidot, Alexis, Hours, Adrien, N'Diaye, Mamadou, Absil, Olivier, Altinier, Lisa, Baudoz, Pierre, Belikov, Ruslan, Bonse, Markus Johannes, Bott, Kimberly, Brandl, Bernhard, Carlotti, Alexis, Casewell, Sarah L., Choquet, Elodie, Cowan, Nicolas B., Desai, Niyati, Doelman, David, Fogarty, Kevin, Gebhard, Timothy D., Gutierrez, Yann, Guyon, Olivier, Herscovici-Schiller, Olivier, Juanola-Parramon, Roser, Kenworthy, Matthew, Kleisioti, Elina, Konig, Lorenzo, Krasteva, Mariya, Laginja, Iva, Leboulleux, Lucie, Mazoyer, Johan, Millar-Blanchaer, Maxwell A., Mouillet, David, Por, Emiel, Pueyo, Laurent, Snik, Frans, van Dam, Dirk, van Gorkom, Kyle, and Vaughan, Sophia R.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Looking to the future of exo-Earth imaging from the ground, core technology developments are required in visible extreme adaptive optics (ExAO) to enable the observation of atmospheric features such as oxygen on rocky planets in visible light. UNDERGROUND (Ultra-fast AO techNology Determination for Exoplanet imageRs from the GROUND), a collaboration built in Feb. 2023 at the Optimal Exoplanet Imagers Lorentz Workshop, aims to (1) motivate oxygen detection in Proxima Centauri b and analogs as an informative science case for high-contrast imaging and direct spectroscopy, (2) overview the state of the field with respect to visible exoplanet imagers, and (3) set the instrumental requirements to achieve this goal and identify what key technologies require further development., Comment: SPIE Proceeding: 2023 / 12680-67
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- 2023
59. Device rounds: T-wave oversensing: A cause of loss of cardiac resynchronization therapy
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Nicolas B. Dayal and Haran Burri
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T-wave oversensing ,Cardiac resynchronisation therapy ,Loss of biventricular pacing ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
A CRT-D patient presented with loss of biventricular pacing associated with heart failure symptoms. The electrocardiogram showed sinus rhythm with alternating wide unpaced and narrower paced QRS complexes. Device interrogation showed T-wave oversensing on all paced biventricular beats, with the following sinus P-wave not tracked due to it falling in the post-ventricular atrial refractory period, leading to intrinsic conduction. Device reprogramming from true bipolar (RV tip to RV ring) sensing to integrated bipolar (RV tip to RV coil) resolved the problem without having to decrease sensitivity values, allowing biventricular pacing close to 100% to resume with improvement of symptoms. T-wave oversensing is a frequently recognised cause of inappropriate therapy in implantable cardioverter defibrillators, but less frequently as a cause of loss of biventricular pacing in CRT-Ds. We review the different non-invasive strategies to overcome this problem.
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- 2016
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60. Creativity Research Overlooks the Study of Resilience among Young Children: A Bibliometric Network Review
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Nicolas B. Verger, Julie Roberts, Jane Guiller, and Kareena McAloney-Kocaman
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Creativity researchers are increasingly interested in understanding when, how, and for whom creativity can be beneficial. Previous reviews have demonstrated that creativity research largely ignores the study of its impact on factors that promote health, and well-being among populations of adults. It is unclear, in fact, whether this gap in research also extends to creativity research among young children. This paper addresses this issue. Early childhood is a crucial stage for the cognitive development of young children who remain highly sensitive to stress, and adversity. It is therefore essential to identify and promote factors that are beneficial to early childhood resilience, thereby contributing to documenting more of the effects of creative activities on positive outcomes. This paper presents a review with a bibliometric analysis of 1000 randomly selected articles from the Web of Science, without bias towards any specific peer-reviewed journal. The analysis of 454 included articles shows that approximately 80% of the included studies focus on creativity as an outcome (replicating previous findings with a larger sample), with only 3.78% investigating creative activities as predictors among young children. In this small percentage, most of the studies addressed creative activities in young children related to resilience outcomes.
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- 2024
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61. The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders
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Nicolas B. Senese, Mark M. Rasenick, and John R. Traynor
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G-protein ,RGS ,antidepressant ,depression ,GPCR ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Progress toward new antidepressant therapies has been relatively slow over the past few decades, with the result that individuals suffering from depression often struggle to find an effective treatment – a process often requiring months. Furthermore, the neural factors that contribute to depression remain poorly understood, and there are many open questions regarding the mechanism of action of existing antidepressants. A better understanding of the molecular processes that underlie depression and contribute to antidepressant efficacy is therefore badly needed. In this review we highlight research investigating the role of G-proteins and the regulators of G-protein signaling (RGS) proteins, two protein families that are intimately involved in both the genesis of depressive states and the action of antidepressant drugs. Many antidepressants are known to indirectly affect the function of these proteins. Conversely, dysfunction of the G-protein and RGS systems can affect antidepressant efficacy. However, a great deal remains unknown about how these proteins interact with antidepressants. Findings pertinent to each individual G-protein and RGS protein are summarized from in vitro, in vivo, and clinical studies.
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- 2018
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62. Multiscale and Anisotropic Characterization of Images Based on Complexity: an Application to Turbulence
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Granero-Belinchon, Carlos, Roux, Stéphane G., and Garnier, Nicolas B.
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Physics - Fluid Dynamics ,Physics - Data Analysis, Statistics and Probability - Abstract
This article presents a multiscale, non-linear and directional statistical characterization of images based on the estimation of the skewness, flatness, entropy and distance from Gaussianity of the spatial increments. These increments are characterized by their magnitude and direction; they allow us to characterize the multiscale properties directionally and to explore anisotropy. To describe the evolution of the probability density function of the increments with their magnitude and direction, we use the skewness to probe the symmetry, the entropy to measure the complexity, and both the flatness and distance from Gaussianity to describe the shape. These four quantities allow us to explore the anisotropy of the linear correlations and non-linear dependencies of the field across scales. First, we validate the methodology on two-dimensional synthetic scale-invariant fields with different multiscale properties and anisotropic characteristics. Then, we apply it on two synthetic turbulent velocity fields: a perfectly isotropic and homogeneous one, and a channel flow where boundaries induce inhomogeneity and anisotropy. Our characterization unambiguously detects the anisotropy in the second case, where our quantities report scaling properties that depend on the direction of analysis. Furthermore, we show in both cases that turbulent velocity fluctuations are always isotropic, when the mean velocity profile is adequately removed.
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- 2023
63. Identification of the Top TESS Objects of Interest for Atmospheric Characterization of Transiting Exoplanets with JWST
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Hord, Benjamin J., Kempton, Eliza M. -R., Mikal-Evans, Thomas, Latham, David W., Ciardi, David R., Dragomir, Diana, Colón, Knicole D., Ross, Gabrielle, Vanderburg, Andrew, de Beurs, Zoe L., Collins, Karen A., Watkins, Cristilyn N., Bean, Jacob, Cowan, Nicolas B., Daylan, Tansu, Morley, Caroline V., Ih, Jegug, Baker, David, Barkaoui, Khalid, Batalha, Natalie M., Behmard, Aida, Belinski, Alexander, Benkhaldoun, Zouhair, Benni, Paul, Bernacki, Krzysztof, Bieryla, Allyson, Binnenfeld, Avraham, Bosch-Cabot, Pau, Bouchy, François, Bozza, Valerio, Brahm, Rafael, Buchhave, Lars A., Calkins, Michael, Chontos, Ashley, Clark, Catherine A., Cloutier, Ryan, Cointepas, Marion, Collins, Kevin I., Conti, Dennis M., Crossfield, Ian J. M., Dai, Fei, de Leon, Jerome P., Dransfield, Georgina, Dressing, Courtney, Dustor, Adam, Esquerdo, Gilbert, Evans, Phil, Fajardo-Acosta, Sergio B., Fiołka, Jerzy, Forés-Toribio, Raquel, Frasca, Antonio, Fukui, Akihiko, Fulton, Benjamin, Furlan, Elise, Gan, Tianjun, Gandolfi, Davide, Ghachoui, Mourad, Giacalone, Steven, Gilbert, Emily A., Gillon, Michaël, Girardin, Eric, Gonzales, Erica, Horta, Ferran Grau, Gregorio, Joao, Greklek-McKeon, Michael, Guerra, Pere, Hartman, J. D., Hellier, Coel, Hełminiak, Krzysztof G., Henning, Thomas, Hill, Michelle L., Horne, Keith, Howard, Andrew W., Howell, Steve B., Huber, Daniel, Isaacson, Howard, Isopi, Giovanni, Jehin, Emmanuel, Jenkins, Jon M., Jensen, Eric L. N., Johnson, Marshall C., Jordán, Andrés, Kane, Stephen R., Kielkopf, John F., Krushinsky, Vadim, Lasota, Sławomir, Lee, Elena, Lewin, Pablo, Livingston, John H., Lubin, Jack, Lund, Michael B., Mallia, Franco, Mann, Christopher R., Marino, Giuseppe, Maslennikova, Nataliia, Massey, Bob, Matson, Rachel, Matthews, Elisabeth, Mayo, Andrew W., Mazeh, Tsevi, McLeod, Kim K., Michaels, Edward J., Močnik, Teo, Mori, Mayuko, Mraz, Georgia, Muñoz, Jose A., Narita, Norio, Nielsen, Louise Dyregaard, Osborn, Hugh, Palle, Enric, Panahi, Aviad, Papini, Riccardo, Polanski, Alex S., Popowicz, Adam, Pozuelos, Francisco J., Quinn, Samuel N., Radford, Don J., Reed, Phillip A., Relles, Howard M., Rice, Malena, Robertson, Paul, Rodriguez, Joseph E., Rosenthal, Lee J., Rubenzahl, Ryan A., Schanche, Nicole, Schlieder, Joshua, Schwarz, Richard P., Sefako, Ramotholo, Shporer, Avi, Sozzetti, Alessandro, Srdoc, Gregor, Stockdale, Chris, Tarasenkov, Alexander, Tan, Thiam-Guan, Timmermans, Mathilde, Ting, Eric B., Van Zandt, Judah, Vignes, JP, Waite, Ian, Watanabe, Noriharu, Weiss, Lauren M., Wittrock, Justin, Zhou, George, Ziegler, Carl, and Zucker, Shay
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Astrophysics - Earth and Planetary Astrophysics - Abstract
JWST has ushered in an era of unprecedented ability to characterize exoplanetary atmospheres. While there are over 5,000 confirmed planets, more than 4,000 TESS planet candidates are still unconfirmed and many of the best planets for atmospheric characterization may remain to be identified. We present a sample of TESS planets and planet candidates that we identify as "best-in-class" for transmission and emission spectroscopy with JWST. These targets are sorted into bins across equilibrium temperature $T_{\mathrm{eq}}$ and planetary radius $R{_\mathrm{p}}$ and are ranked by transmission and emission spectroscopy metric (TSM and ESM, respectively) within each bin. In forming our target sample, we perform cuts for expected signal size and stellar brightness, to remove sub-optimal targets for JWST. Of the 194 targets in the resulting sample, 103 are unconfirmed TESS planet candidates, also known as TESS Objects of Interest (TOIs). We perform vetting and statistical validation analyses on these 103 targets to determine which are likely planets and which are likely false positives, incorporating ground-based follow-up from the TESS Follow-up Observation Program (TFOP) to aid the vetting and validation process. We statistically validate 23 TOIs, marginally validate 33 TOIs to varying levels of confidence, deem 29 TOIs likely false positives, and leave the dispositions for 4 TOIs as inconclusive. 14 of the 103 TOIs were confirmed independently over the course of our analysis. We provide our final best-in-class sample as a community resource for future JWST proposals and observations. We intend for this work to motivate formal confirmation and mass measurements of each validated planet and encourage more detailed analysis of individual targets by the community., Comment: Submitted to AJ. Machine-readable versions of Tables 2 and 3 are included. 40 pages, 7 figures, 3 tables
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- 2023
64. The Role of Magma Oceans in Maintaining Surface Water on Rocky Planets Orbiting M-Dwarfs
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Moore, Keavin, Cowan, Nicolas B., and Boukaré, Charles-Édouard
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Earth-like planets orbiting M-dwarf stars, M-Earths, are currently the best targets to search for signatures of life. Life as we know it requires water. The habitability of M-Earths is jeopardized by water loss to space: high flux from young M-dwarf stars can drive the loss of 3--20 Earth oceans from otherwise habitable planets. We develop a 0-D box model for Earth-mass terrestrial exoplanets, orbiting within the habitable zone, which tracks water loss to space and exchange between reservoirs during an early surface magma ocean phase and the longer deep-water cycling phase. A key feature is the duration of the surface magma ocean, assumed concurrent with the runaway greenhouse. This timescale can discriminate between desiccated planets, planets with desiccated mantles but substantial surface water, and planets with significant water sequestered in the mantle. A longer-lived surface magma ocean helps M-Earths retain water: dissolution of water in the magma provides a barrier against significant loss to space during the earliest, most active stage of the host M-dwarf, depending on the water saturation limit of the magma. Although a short-lived basal magma ocean can be beneficial to surface habitability, a long-lived basal magma ocean may sequester significant water in the mantle at the detriment of surface habitability. We find that magma oceans and deep-water cycling can maintain or recover habitable surface conditions on Earth-like planets at the inner edge of the habitable zone around late M-dwarf stars -- these planets would otherwise be desiccated if they form with less than ${\sim}$10 terrestrial oceans of water., Comment: 14 pages, 5 figures, accepted to MNRAS
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- 2023
65. Chasing rainbows and ocean glints: Inner working angle constraints for the Habitable Worlds Observatory
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Vaughan, Sophia R., Gebhard, Timothy D., Bott, Kimberly, Casewell, Sarah L., Cowan, Nicolas B., Doelman, David S., Kenworthy, Matthew, Mazoyer, Johan, Millar-Blanchaer, Maxwell A., Trees, Victor J. H., Stam, Daphne M., Absil, Olivier, Altinier, Lisa, Baudoz, Pierre, Belikov, Ruslan, Bidot, Alexis, Birkby, Jayne L., Bonse, Markus J., Brandl, Bernhard, Carlotti, Alexis, Choquet, Elodie, van Dam, Dirk, Desai, Niyati, Fogarty, Kevin, Fowler, J., van Gorkom, Kyle, Gutierrez, Yann, Guyon, Olivier, Haffert, Sebastiaan Y., Herscovici-Schiller, Olivier, Hours, Adrien, Juanola-Parramon, Roser, Kleisioti, Evangelia, König, Lorenzo, van Kooten, Maaike, Krasteva, Mariya, Laginja, Iva, Landman, Rico, Leboulleux, Lucie, Mouillet, David, N'Diaye, Mamadou, Por, Emiel H., Pueyo, Laurent, and Snik, Frans
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Astrophysics - Earth and Planetary Astrophysics - Abstract
NASA is engaged in planning for a Habitable Worlds Observatory (HabWorlds), a coronagraphic space mission to detect rocky planets in habitable zones and establish their habitability. Surface liquid water is central to the definition of planetary habitability. Photometric and polarimetric phase curves of starlight reflected by an exoplanet can reveal ocean glint, rainbows and other phenomena caused by scattering by clouds or atmospheric gas. Direct imaging missions are optimised for planets near quadrature, but HabWorlds' coronagraph may obscure the phase angles where such optical features are strongest. The range of accessible phase angles for a given exoplanet will depend on the planet's orbital inclination and/or the coronagraph's inner working angle (IWA). We use a recently-created catalog relevant to HabWorlds of 164 stars to estimate the number of exo-Earths that could be searched for ocean glint, rainbows, and polarization effects due to Rayleigh scattering. We find that the polarimetric Rayleigh scattering peak is accessible in most of the exo-Earth planetary systems. The rainbow due to water clouds at phase angles of ${\sim}20-60^\circ$ would be accessible with HabWorlds for a planet with an Earth equivalent instellation in ${\sim}{46}$ systems, while the ocean glint signature at phase angles of ${\sim}130-170^\circ$ would be accessible in ${\sim}{16}$ systems, assuming an IWA${=}62$ mas ($3\lambda/D$). Improving the IWA${=}41$ mas ($2\lambda/D$) increases accessibility to rainbows and glints by factors of approximately 2 and 3, respectively. By observing these scattering features, HabWorlds could detect a surface ocean and water cycle, key indicators of habitability., Comment: MNRAS accepted, 9 pages, 8 figures, 3 tables
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- 2023
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66. Warm Jupiters Beyond the Tidal Synchronization Limit May Exhibit a Wide Range of Secondary Eclipse Depths
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Rauscher, Emily, Cowan, Nicolas B., and Luger, Rodrigo
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Astrophysics - Earth and Planetary Astrophysics - Abstract
With JWST we can now characterize the atmospheres of planets on longer orbital planets, but this moves us into a regime where we cannot assume that tidal forces from the star have eroded planets' obliquities and synchronized their rotation rates. These rotation vectors may be tracers of formation and evolution histories and also enable a range of atmospheric circulation states. Here we delineate the orbital space over which tidal synchronization and alignment assumptions may no longer apply and present three-dimensional atmospheric models of a hypothetical warm Jupiter over a range of rotation rates and obliquities. We simulate the secondary eclipses of this planet for different possible viewing orientations and times during its orbital, seasonal cycle. We find that the eclipse depth can be strongly influenced by rotation rate and obliquity through the timing of the eclipse relative to the planet's seasonal cycle, and advise caution in attempting to derive properties such as albedo or day-night transport from this measurement. We predict that if warm Jupiters beyond the tidal limit have intrinsic diversity in their rotation vectors, then it will manifest itself as dispersion in their secondary eclipse depths. We explore eclipse mapping as a way to uniquely constrain the rotation vector of warm Jupiters but find that the associated signals are likely at the edge of JWST performance. Nevertheless, as JWST begins to measure the secondary eclipses of longer orbital period planets, we should expect to observe the consequences of a wider range of rotation states and circulation patterns., Comment: 14 pages, 6 figures, animated figures available in the journal's online version
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- 2023
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67. Genetic control of abiotic stress-related specialized metabolites in sunflower
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Moroldo, Marco, Blanchet, Nicolas, Duruflé, Harold, Bernillon, Stéphane, Berton, Thierry, Fernandez, Olivier, Gibon, Yves, Moing, Annick, and Langlade, Nicolas B.
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- 2024
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68. Genomic Prediction of Sunflower Hybrids Oil Content
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Brigitte Mangin, Fanny Bonnafous, Nicolas Blanchet, Marie-Claude Boniface, Emmanuelle Bret-Mestries, Sébastien Carrère, Ludovic Cottret, Ludovic Legrand, Gwenola Marage, Prune Pegot-Espagnet, Stéphane Munos, Nicolas Pouilly, Felicity Vear, Patrick Vincourt, and Nicolas B. Langlade
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genomic selection ,factorial design ,sunflower ,oil content ,hybrid ,GBS ,Plant culture ,SB1-1110 - Abstract
Prediction of hybrid performance using incomplete factorial mating designs is widely used in breeding programs including different heterotic groups. Based on the general combining ability (GCA) of the parents, predictions are accurate only if the genetic variance resulting from the specific combining ability is small and both parents have phenotyped descendants. Genomic selection (GS) can predict performance using a model trained on both phenotyped and genotyped hybrids that do not necessarily include all hybrid parents. Therefore, GS could overcome the issue of unknown parent GCA. Here, we compared the accuracy of classical GCA-based and genomic predictions for oil content of sunflower seeds using several GS models. Our study involved 452 sunflower hybrids from an incomplete factorial design of 36 female and 36 male lines. Re-sequencing of parental lines allowed to identify 468,194 non-redundant SNPs and to infer the hybrid genotypes. Oil content was observed in a multi-environment trial (MET) over 3 years, leading to nine different environments. We compared GCA-based model to different GS models including female and male genomic kinships with the addition of the female-by-male interaction genomic kinship, the use of functional knowledge as SNPs in genes of oil metabolic pathways, and with epistasis modeling. When both parents have descendants in the training set, the predictive ability was high even for GCA-based prediction, with an average MET value of 0.782. GS performed slightly better (+0.2%). Neither the inclusion of the female-by-male interaction, nor functional knowledge of oil metabolism, nor epistasis modeling improved the GS accuracy. GS greatly improved predictive ability when one or both parents were untested in the training set, increasing GCA-based predictive ability by 10.4% from 0.575 to 0.635 in the MET. In this scenario, performing GS only considering SNPs in oil metabolic pathways did not improve whole genome GS prediction but increased GCA-based prediction ability by 6.4%. Our results show that GS is a major improvement to breeding efficiency compared to the classical GCA modeling when either one or both parents are not well-characterized. This finding could therefore accelerate breeding through reducing phenotyping efforts and more effectively targeting for the most promising crosses.
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- 2017
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69. Prominent features of the amino acid mutation landscape in cancer.
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Zachary A Szpiech, Nicolas B Strauli, Katharine A White, Diego Garrido Ruiz, Matthew P Jacobson, Diane L Barber, and Ryan D Hernandez
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Medicine ,Science - Abstract
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver mutations, and genetic signatures. Accordingly, each of these distinctions have been used to classify cancer subtypes and to reveal common features. Here, we present a different analysis of cancer based on amino acid mutation signatures. Non-negative Matrix Factorization and principal component analysis of 29 cancers revealed six amino acid mutation signatures, including four signatures that were dominated by either arginine to histidine (Arg>His) or glutamate to lysine (Glu>Lys) mutations. Sample-level analyses reveal that while some cancers are heterogeneous, others are largely dominated by one type of mutation. Using a non-overlapping set of samples from the COSMIC somatic mutation database, we validate five of six mutation signatures, including signatures with prominent arginine to histidine (Arg>His) or glutamate to lysine (Glu>Lys) mutations. This suggests that our classification of cancers based on amino acid mutation patterns may provide avenues of inquiry pertaining to specific protein mutations that may generate novel insights into cancer biology.
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- 2017
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70. Awesome SOSS: Transmission Spectroscopy of WASP-96b with NIRISS/SOSS
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Radica, Michael, Welbanks, Luis, Espinoza, Néstor, Taylor, Jake, Coulombe, Louis-Philippe, Feinstein, Adina D., Goyal, Jayesh, Scarsdale, Nicholas, Albert, Loic, Baghel, Priyanka, Bean, Jacob L., Blecic, Jasmina, Lafrenière, David, MacDonald, Ryan J., Zamyatina, Maria, Allart, Romain, Artigau, Étienne, Batalha, Natasha E., Cook, Neil James, Cowan, Nicolas B., Dang, Lisa, Doyon, René, Fournier-Tondreau, Marylou, Johnstone, Doug, Line, Michael R., Moran, Sarah E., Mukherjee, Sagnick, Pelletier, Stefan, Roy, Pierre-Alexis, Talens, Geert Jan, Filippazzo, Joseph, Pontoppidan, Klaus, and Volk, Kevin
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The future is now - after its long-awaited launch in December 2021, JWST began science operations in July 2022 and is already revolutionizing exoplanet astronomy. The Early Release Observations (ERO) program was designed to provide the first images and spectra from JWST, covering a multitude of science cases and using multiple modes of each on-board instrument. Here, we present transmission spectroscopy observations of the hot-Saturn WASP-96b with the Single Object Slitless Spectroscopy (SOSS) mode of the Near Infrared Imager and Slitless Spectrograph, observed as part of the ERO program. As the SOSS mode presents some unique data reduction challenges, we provide an in-depth walk-through of the major steps necessary for the reduction of SOSS data: including background subtraction, correction of 1/f noise, and treatment of the trace order overlap. We furthermore offer potential routes to correct for field star contamination, which can occur due to the SOSS mode's slitless nature. By comparing our extracted transmission spectrum with grids of atmosphere models, we find an atmosphere metallicity between 1x and 5x solar, and a solar carbon-to-oxygen ratio. Moreover, our models indicate that no grey cloud deck is required to fit WASP-96b's transmission spectrum, but find evidence for a slope shortward of 0.9$\mu$m, which could either be caused by enhanced Rayleigh scattering or the red wing of a pressure-broadened Na feature. Our work demonstrates the unique capabilities of the SOSS mode for exoplanet transmission spectroscopy and presents a step-by-step reduction guide for this new and exciting instrument., Comment: MNRAS, in press. Updated to reflect published version
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- 2023
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71. CO or no CO? Narrowing the CO abundance constraint and recovering the H2O detection in the atmosphere of WASP-127 b using SPIRou
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Boucher, Anne, Lafrenière, David, Pelletier, Stefan, Darveau-Bernier, Antoine, Radica, Michael, Allart, Romain, Artigau, Étienne, Cook, Neil J., Debras, Florian, Doyon, René, Gaidos, Eric, Benneke, Björn, Cadieux, Charles, Carmona, Andres, Cloutier, Ryan, Cortés-Zuleta, Pía, Cowan, Nicolas B., Delfosse, Xavier, Donati, Jean-François, Fouqué, Pascal, Forveille, Thierry, Grankin, Konstantin, Hébrard, Guillaume, Martins, Jorge H. C., Martioli, Eder, Masson, Adrien, and Vinatier, Sandrine
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Precise measurements of chemical abundances in planetary atmospheres are necessary to constrain the formation histories of exoplanets. A recent study of WASP-127b, a close-in puffy sub-Saturn orbiting its solar-type host star in 4.2 d, using HST and Spitzer revealed a feature-rich transmission spectrum with strong excess absorption at 4.5 um. However, the limited spectral resolution and coverage of these instruments could not distinguish between CO and/or CO2 absorption causing this signal, with both low and high C/O ratio scenarios being possible. Here we present near-infrared (0.9--2.5 um) transit observations of WASP-127 b using the high-resolution SPIRou spectrograph, with the goal to disentangle CO from CO2 through the 2.3 um CO band. With SPIRou, we detect H2O at a t-test significance of 5.3 sigma and observe a tentative (3 sigma) signal consistent with OH absorption. From a joint SPIRou + HST + Spitzer retrieval analysis, we rule out a CO-rich scenario by placing an upper limit on the CO abundance of log10[CO]<-4.0, and estimate a log10[CO2] of -3.7^(+0.8)_(-0.6), which is the level needed to match the excess absorption seen at 4.5um. We also set abundance constraints on other major C-, O-, and N-bearing molecules, with our results favoring low C/O (0.10^(+0.10)_(-0.06)), disequilibrium chemistry scenarios. We further discuss the implications of our results in the context of planet formation. Additional observations at high and low-resolution will be needed to confirm these results and better our understanding of this unusual world., Comment: 23 pages, 13 figures, Submitted for publication in the Monthly Notice of the Royal Astronomical Society
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- 2023
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72. Effect of Ocrelizumab on B- and T-Cell Receptor Repertoire Diversity in Patients With Relapsing Multiple Sclerosis From the Randomized Phase III OPERA Trial
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Laurent, Sarah A, Strauli, Nicolas B, Eggers, Erica L, Wu, Hao, Michel, Brady, Demuth, Stanislas, Palanichamy, Arumugam, Wilson, Michael R, Sirota, Marina, Hernandez, Ryan D, Cree, Bruce Anthony Campbell, Herman, Ann E, and von Büdingen, H-Christian
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Immunotherapy ,Minority Health ,Clinical Research ,Clinical Trials and Supportive Activities ,Health Disparities ,Autoimmune Disease ,Inflammatory and immune system ,Humans ,Multiple Sclerosis ,Immunologic Factors ,Antibodies ,Monoclonal ,Humanized ,Recurrence ,Receptors ,Antigen ,T-Cell ,Neurosciences - Abstract
Background and objectivesThe B cell-depleting anti-CD20 antibody ocrelizumab (OCR) effectively reduces MS disease activity and slows disability progression. Given the role of B cells as antigen-presenting cells, the primary goal of this study was to evaluate the effect of OCR on the T-cell receptor repertoire diversity.MethodsTo examine whether OCR substantially alters the molecular diversity of the T-cell receptor repertoire, deep immune repertoire sequencing (RepSeq) of CD4+ and CD8+ T-cell receptor β-chain variable regions was performed on longitudinal blood samples. The IgM and IgG heavy chain variable region repertoire was also analyzed to characterize the residual B-cell repertoire under OCR treatment.ResultsPeripheral blood samples for RepSeq were obtained from 8 patients with relapsing MS enrolled in the OPERA I trial over a period of up to 39 months. Four patients each were treated with OCR or interferon β1-a during the double-blind period of OPERA I. All patients received OCR during the open-label extension. The diversity of the CD4+/CD8+ T-cell repertoires remained unaffected in OCR-treated patients. The expected OCR-associated B-cell depletion was mirrored by reduced B-cell receptor diversity in peripheral blood and a shift in immunoglobulin gene usage. Despite deep B-cell depletion, longitudinal persistence of clonally related B-cells was observed.DiscussionOur data illustrate that the diversity of CD4+/CD8+ T-cell receptor repertoires remained unaltered in OCR-treated patients with relapsing MS. Persistence of a highly diverse T-cell repertoire suggests that aspects of adaptive immunity remain intact despite extended anti-CD20 therapy.Trial registration informationThis is a substudy (BE29353) of the OPERA I (WA21092; NCT01247324) trial. Date of registration, November 23, 2010; first patient enrollment, August 31, 2011.
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- 2023
73. OGLE-2016-BLG-1195Lb: A Sub-Neptune Beyond the Snow Line of an M-dwarf Confirmed by Keck AO
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Vandorou, Aikaterini, Dang, Lisa, Bennett, David P., Koshimoto, Naoki, Terry, Sean K., Beaulieu, Jean-Phillipe, Alard, Christophe, Bhattacharya, Aparna, Blackman, Joshua W., Bouchoutrouch-Ku, Tarik, Cole, Andrew A., Cowan, Nicolas B., Marquette, Jean-Baptiste, Ranc, Clément, and Rektsini, Natalia
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present the analysis of high resolution follow-up observations of OGLE-2016-BLG-1195 using Laser Guide Star Adaptive Optics with Keck, seven years after the event's peak. We resolve the lens, measuring its flux and the relative source-lens proper motion, thus finding the system to be a $M_{\rm p} = 10.08\pm 1.18\ M_{\rm \oplus}$ planet orbiting an M-dwarf, $M_{\rm L} = 0.62\pm 0.05\ M_{\odot}$, beyond the snow line, with a projected separation of $r_\perp=2.24\pm 0.21$ AU at $D_{\rm L} = 7.45\pm 0.55$ kpc. Our results are consistent with the discovery paper, which reports values with 1-sigma uncertainties based on a single mass-distance constraint from finite source effects. However, both the discovery paper and our follow-up results disagree with the analysis of a different group that also present the planetary signal detection. The latter utilizes \textit{Spitzer} photometry to measure a parallax signal claiming the system is an Earth-mass planet orbiting an ultracool dwarf. Their parallax signal though is improbable since it suggests a lens star in the disk moving perpendicular to Galactic rotation. Moreover, microlensing parallaxes can be impacted by systematic errors in the photometry. Therefore, we reanalyze the \textit{Spitzer} photometry using a Pixel Level Decorrelation (PLD) model to detrend detector systematics. We find that we can not confidently recover the same detrended light curve that is likely dominated by systematic errors in the photometric data. The results of this paper act as a cautionary tale that a careful understanding of detector systematics and how they influence astrophysical constraints is crucial., Comment: Submitted to AJ
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- 2023
74. The Roasting Marshmallows Program with IGRINS on Gemini South I: Composition and Climate of the Ultra Hot Jupiter WASP-18 b
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Brogi, Matteo, Emeka-Okafor, Vanessa, Line, Michael R., Gandhi, Siddharth, Pino, Lorenzo, Kempton, Eliza M. -R., Rauscher, Emily, Parmentier, Vivien, Bean, Jacob L., Mace, Gregory N., Cowan, Nicolas B., Shkolnik, Evgenya, Wardenier, Joost P., Mansfield, Megan, Welbanks, Luis, Smith, Peter, Fortney, Jonathan J., Birkby, Jayne L., Zalesky, Joseph A., Dang, Lisa, Patience, Jennifer, and Désert, Jean-Michel
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present high-resolution dayside thermal emission observations of the exoplanet WASP-18b using IGRINS on Gemini South. We remove stellar and telluric signatures using standard algorithms, and we extract the planet signal via cross correlation with model spectra. We detect the atmosphere of WASP-18b at a signal-to-noise ratio (SNR) of 5.9 using a full chemistry model, measure H2O (SNR=3.3), CO (SNR=4.0), and OH (SNR=4.8) individually, and confirm previous claims of a thermal inversion layer. The three species are confidently detected (>4$\sigma$) with a Bayesian inference framework, which we also use to retrieve abundance, temperature, and velocity information. For this ultra-hot Jupiter (UHJ), thermal dissociation processes likely play an important role. Retrieving abundances constant with altitude and allowing the temperature-pressure profile to freely adjust results in a moderately super-stellar carbon to oxygen ratio (C/O=0.75^{+0.14}_{-0.17}) and metallicity ([M/H]=1.03^{+0.65}_{-1.01}). Accounting for undetectable oxygen produced by thermal dissociation leads to C/O=0.45^{+0.08}_{-0.10} and [M/H]=1.17^{+0.66}_{-1.01}. A retrieval that assumes radiative-convective-thermochemical-equilibrium and naturally accounts for thermal dissociation constrains C/O<0.34 (2$\sigma$) and [M/H]=0.48^{+0.33}_{-0.29}, in line with the chemistry of the parent star. Looking at the velocity information, we see a tantalising signature of different Doppler shifts at the level of a few km/s for different molecules, which might probe dynamics as a function of altitude and location on the planet disk. Our results demonstrate that ground-based, high-resolution spectroscopy at infrared wavelengths can provide meaningful constraints on the compositions and climate of highly irradiated planets. This work also elucidates potential pitfalls with commonly employed retrieval assumptions when applied to UHJ spectra., Comment: 27 pages, 18 figures, submitted to AAS Journals. Community feedback welcome
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- 2022
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75. Revisiting the Iconic Spitzer Phase Curve of 55 Cancri e: Hotter Dayside, Cooler Nightside and Smaller Phase Offset
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Mercier, Samson J., Dang, Lisa, Gass, Alexander, Cowan, Nicolas B., and Bell, Taylor J.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Thermal phase curves of short period exoplanets provide the best constraints on the atmospheric dynamics and heat transport in their atmospheres. The published Spitzer Space Telescope phase curve of 55 Cancri e, an ultra-short period super-Earth, exhibits a large phase offset suggesting significant eastward heat recirculation, unexpected on such a hot planet arXiv:1604.05725. We present our re-reduction and analysis of these iconic observations using the open source and modular Spitzer Phase Curve Analysis (SPCA) pipeline. In particular, we attempt to reproduce the published analysis using the same instrument detrending scheme as the original authors. We retrieve the dayside temperature ($T_{\rm day} = 3771^{+669}_{-520}$ K), nightside temperature ($T_{\rm night} < 1649$ K at $2\sigma$), and longitudinal offset of the planet's hot spot and quantify how they depend on the reduction and detrending. Our re-analysis suggests that 55 Cancri e has a negligible hot spot offset of $-12^{+21}_{-18}$ degrees east. The small phase offset and cool nightside are consistent with the poor heat transport expected on ultra-short period planets. The high dayside 4.5-micrometer brightness temperature is qualitatively consistent with SiO emission from an inverted rock vapour atmosphere., Comment: Accepted for publication in AAS Journals. Includes 12 pages, 4 figures, and 3 tables
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- 2022
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76. Evaluating connectivity models for conservation: insights from African lion dispersal patterns
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Finerty, Genevieve E., Cushman, Samuel A., Bauer, Dominik T., Elliot, Nicolas B., Kesch, M. Kristina, Macdonald, David W., and Loveridge, Andrew J.
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- 2023
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77. The role of cellular coupling in the spontaneous generation of electrical activity in uterine tissue.
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Jinshan Xu, Shakti N Menon, Rajeev Singh, Nicolas B Garnier, Sitabhra Sinha, and Alain Pumir
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Medicine ,Science - Abstract
The spontaneous emergence of contraction-inducing electrical activity in the uterus at the beginning of labor remains poorly understood, partly due to the seemingly contradictory observation that isolated uterine cells are not spontaneously active. It is known, however, that the expression of gap junctions increases dramatically in the approach to parturition, by more than one order of magnitude, which results in a significant increase in inter-cellular electrical coupling. In this paper, we build upon previous studies of the activity of electrically excitable smooth muscle cells (myocytes) and investigate the mechanism through which the coupling of these cells to electrically passive cells results in the generation of spontaneous activity in the uterus. Using a recently developed, realistic model of uterine muscle cell dynamics, we investigate a system consisting of a myocyte coupled to passive cells. We then extend our analysis to a simple two-dimensional lattice model of the tissue, with each myocyte being coupled to its neighbors, as well as to a random number of passive cells. We observe that different dynamical regimes can be observed over a range of gap junction conductances: at low coupling strength, corresponding to values measured long before delivery, the activity is confined to cell clusters, while the activity for high coupling, compatible with values measured shortly before delivery, may spread across the entire tissue. Additionally, we find that the system supports the spontaneous generation of spiral wave activity. Our results are both qualitatively and quantitatively consistent with observations from in vitro experiments. In particular, we demonstrate that the increase in inter-cellular electrical coupling observed experimentally strongly facilitates the appearance of spontaneous action potentials that may eventually lead to parturition.
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- 2015
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78. The TORC2 component, Sin1, controls migration of anterior mesendoderm during zebrafish gastrulation.
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Julien G Dumortier and Nicolas B David
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Medicine ,Science - Abstract
TORC2 is a serine-threonine kinase complex conserved through evolution that recently emerged as a new regulator of actin dynamics and cell migration. However, knockout in mice of its core components Sin1 and Rictor is embryonic lethal, which has limited in vivo analyses. Here, we analysed TORC2 function during early zebrafish development, using a morpholino-mediated loss of function of sin1. Sin1 appears required during gastrulation for migration of the prechordal plate, the anterior most mesoderm. In absence of Sin1, cells migrate both slower and less persistently, which can be correlated to a reduction in actin-rich protrusions and a randomisation of the remaining protrusions. These results demonstrate that, as established in vitro, the TORC2 component Sin1 controls actin dynamics and cell migration in vivo. We furthermore establish that Sin1 is required for protrusion formation downstream of PI3K, and is acting upstream of the GTPase Rac1, since expression of an activated form of Rac1 is sufficient to rescue sin1 loss of function.
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- 2015
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79. Association of MnSOD AA Genotype with the Progression of Prostate Cancer.
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Taro Iguchi, Ching Y Wang, Nicolas B Delongchamps, Minoru Kato, Satoshi Tamada, Takeshi Yamasaki, Gustavo de la Roza, Tatsuya Nakatani, and Gabriel P Haas
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Medicine ,Science - Abstract
To investigate whether manganese superoxide dismutase (MnSOD) genetic polymorphism is associated with the clinical significance of prostate cancer.Prostates were obtained from 194 deceased men 45 years or older who did not have a history of prostate cancer. Serial sections and histological examinations of the prostate were performed. The MnSOD genotypes of the specimens were determined by polymerase chain reaction restriction fragment length polymorphism analysis.Of the 194 men, 31 and 26 had clinically insignificant and significant prostate cancer. Clinically significant cancer comprised 29% and 58% of the cancers in men 70 years old, respectively. The age-specific proportion of significant cancer significantly increased with the advance of age (p
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- 2015
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80. GJ 1252b: A Hot Terrestrial Super-Earth With No Atmosphere
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Crossfield, Ian J. M., Malik, Matej, Hill, Michelle L., Kane, Stephen R., Foley, Bradford, Polanski, Alex S., Coria, David, Brande, Jonathan, Zhang, Yanzhe, Wienke, Katherine, Kreidberg, Laura, Cowan, Nicolas B., Dragomir, Diana, Gorjian, Varoujan, Mikal-Evans, Thomas, Benneke, Bjoern, Christiansen, Jessie L., Deming, Drake, and Morales, Farisa Y.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The increasing numbers of rocky, terrestrial exoplanets known to orbit nearby stars (especially M dwarfs) has drawn increased attention to the possibility of studying these planets' surface properties, and atmospheric compositions & escape histories. Here we report the detection of the secondary eclipse of the terrestrial exoplanet GJ1252b using the Spitzer Space Telescope's IRAC2 4.5 micron channel. We measure an eclipse depth of 149(+25/-32) ppm, corresponding to a day-side brightness temperature of 1410(+91/-125) K and consistent with the prediction for no atmosphere. Comparing our measurement to atmospheric models indicates that GJ1252b has a surface pressure of <10 bar, substantially less than Venus. Assuming energy-limited escape, even a 100 bar atmosphere would be lost in <1 Myr, far shorter than estimated age of 3.9+/-0.4 Gyr. The expected mass loss could be overcome by mantle outgassing, but only if the mantle's carbon content were >7% by mass - over two orders of magnitude greater than that found in Earth. We therefore conclude that GJ1252b has no significant atmosphere. Model spectra with granitoid or feldspathic surface composition, but with no atmosphere, are disfavored at >2 sigma. The eclipse occurs just +1.4(+2.8/-1.0) min after orbital phase 0.5, indicating e cos omega=+0.0025(+0.0049/-0.0018), consistent with a circular orbit. Tidal heating is therefore likely to be negligible to GJ1252b's global energy budget. Finally, we also analyze additional, unpublished TESS transit photometry of GJ1252b which improves the precision of the transit ephemeris by a factor of ten, provides a more precise planetary radius of 1.180+/-0.078 R_E, and rules out any transit timing variations with amplitudes <1 min., Comment: ApJL in press. 16 pages, 12 figures, 10 eclipses, 1 bandpass. Models will be available at journal website
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- 2022
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81. Combining Photometry and Astrometry to Improve Orbit Retrieval of Directly Imaged Exoplanets
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Bruna, Margaret, Cowan, Nicolas B., Sheffler, Julia, Haggard, Hal M., Bourdon, Audrey, and Mâlin, Mathilde
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Future missions like Roman, HabEx, and LUVOIR will directly image exoplanets in reflected light. While current near infrared direct imaging searches are only sensitive to young, self-luminous planets whose brightness is independent of their orbital phase, reflected light imaging will reveal changes in planet brightness over the course of an orbit due to phase variations. One of the first objectives will be determining the planet's orbit via astrometry, the projected position of the planet with respect to its host star in the sky plane. We show that phase variations can significantly improve the accuracy and precision of orbital retrieval with two or three direct images. This would speed up the classification of exoplanets and improve the efficiency of subsequent spectroscopic characterization. We develop a forward model to generate synthetic observations of the two dimensional position of the planet with respect to its host star on the sky plane, and the planet/star flux ratio. Synthetic data are fitted with Keplerian orbits and Henyey-Greenstein phase variations to retrieve orbital and phase parameters. For astrometric uncertainties of 0.01 AU in projected separation and flux ratio uncertainties of 10^-12, using photometry in orbit retrieval improves the accuracy of semi-major axis by 47% for two epochs and 61% for three epochs if the phase curves have a known shape, but unknown amplitude. In the more realistic scenario where the shape and amplitude of the phase curve are a priori unknown, photometry still improves accuracy by 16% for two epochs and 50% for three., Comment: 11 pages, 6 figures. Monthly Notices of the Royal Astronomical Society, in press
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- 2022
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82. TOI-1452 b: SPIRou and TESS reveal a super-Earth in a temperate orbit transiting an M4 dwarf
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Cadieux, Charles, Doyon, René, Plotnykov, Mykhaylo, Hébrard, Guillaume, Jahandar, Farbod, Artigau, Étienne, Valencia, Diana, Cook, Neil J., Martioli, Eder, Vandal, Thomas, Donati, Jean-François, Cloutier, Ryan, Narita, Norio, Fukui, Akihiko, Hirano, Teruyuki, Bouchy, François, Cowan, Nicolas B., Gonzales, Erica J., Ciardi, David R., Stassun, Keivan G., Arnold, Luc, Benneke, Björn, Boisse, Isabelle, Bonfils, Xavier, Carmona, Andrés, Cortés-Zuleta, Pía, Delfosse, Xavier, Forveille, Thierry, Fouqué, Pascal, da Silva, João Gomes, Jenkins, Jon M., Kiefer, Flavien, Kóspál, Ágnes, Lafrenière, David, Martins, Jorge H. C., Moutou, Claire, Nascimento Jr., J. -D. do, Ould-Elhkim, Merwan, Pelletier, Stefan, Twicken, Joseph D., Bouma, Luke G., Cartwright, Scott, Darveau-Bernier, Antoine, Grankin, Konstantin, Ikoma, Masahiro, Kagetani, Taiki, Kawauchi, Kiyoe, Kodama, Takanori, Kotani, Takayuki, Latham, David W., Menou, Kristen, Ricker, George, Seager, Sara, Tamura, Motohide, Vanderspek, Roland, and Watanabe, Noriharu
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Exploring the properties of exoplanets near or inside the radius valley provides insights on the transition from the rocky super-Earths to the larger, hydrogen-rich atmosphere mini-Neptunes. Here, we report the discovery of TOI-1452 b, a transiting super-Earth ($R_{\rm p} = 1.67 \pm 0.07$ R$_{\oplus}$) in an 11.1--day temperate orbit ($T_{\rm eq} = 326 \pm 7$ K) around the primary member ($H = 10.0$, $T_{\rm eff} = 3185 \pm 50$ K) of a nearby visual binary M dwarf. The transits were first detected by TESS, then successfully isolated between the two $3.2^{\prime\prime}$ companions with ground-based photometry from OMM and MuSCAT3. The planetary nature of TOI-1452 b was established through high-precision velocimetry with the near-infrared SPIRou spectropolarimeter as part of the ongoing SPIRou Legacy Survey. The measured planetary mass ($4.8 \pm 1.3$ M$_{\oplus}$) and inferred bulk density ($5.6^{+1.8}_{-1.6}$ g/cm$^3$) is suggestive of a rocky core surrounded by a volatile-rich envelope. More quantitatively, the mass and radius of TOI-1452 b, combined with the stellar abundance of refractory elements (Fe, Mg and Si) measured by SPIRou, is consistent with a core mass fraction of $18\pm6$ % and a water mass fraction of $22^{+21}_{-13}$%. The water world candidate TOI-1452 b is a prime target for future atmospheric characterization with JWST, featuring a Transmission Spectroscopy Metric similar to other well-known temperate small planets such as LHS 1140 b and K2-18 b. The system is located near Webb's northern Continuous Viewing Zone, implying that is can be followed at almost any moment of the year., Comment: Published in The Astronomical Journal
- Published
- 2022
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83. Atmospheric gravitational tides of Earth-like planets orbiting low-mass stars
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Navarro, Thomas, Merlis, Timothy M., Cowan, Nicolas B., and Gomez, Natalya
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Temperate terrestrial planets orbiting low-mass stars are subject to strong tidal forces. The effects of gravitational tides on the solid planet and that of atmospheric thermal tides have been studied, but the direct impact of gravitational tides on the atmosphere itself has so far been ignored. We first develop a simplified analytic theory of tides acting on the atmosphere of a planet. We then implement gravitational tides into a general circulation model of a static-ocean planet in a short-period orbit around a low-mass star -- the results agree with our analytic theory. Because atmospheric tides and solid-body tides share a scaling with the semi-major axis, we show that there is a maximum amplitude of the atmospheric tide that a terrestrial planet can experience while still having a solid surface; Proxima Centauri b is the poster child for a planet that could be geophysically Earth-like but with atmospheric tides more than 500$\times$ stronger than Earth's. In this most extreme scenario, we show that atmospheric tides significantly impact the planet's meteorology -- but not its climate. Two possible modest climate impacts are enhanced longitudinal heat transport and cooling of the lowest atmospheric layers. The strong radiative forcing of such planets dominates over gravitational tides, unlike moons of cold giant planets, such as Titan. We speculate that atmospheric tides could be climatologically important on planets where the altitude of maximal tidal forcing coincides with the altitude of cloud formation and that the effect could be detectable for non-Earth-like planets subject to even greater tides.
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- 2022
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84. Stratospheric Clouds Do Not Impede JWST Transit Spectroscopy for Exoplanets with Earth-Like Atmospheres
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Doshi, Dhvani, Cowan, Nicolas B., and Huang, Yi
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
The James Webb Space Telescope (JWST) will provide an opportunity to investigate the atmospheres of potentially habitable planets. Aerosols, significantly mute molecular features in transit spectra because they prevent light from probing the deeper layers of the atmosphere. Earth occasionally has stratospheric/high tropospheric clouds at 15-20 km that could substantially limit the observable depth of the underlying atmosphere. We use solar occultations of Earth's atmosphere to create synthetic JWST transit spectra of Earth analogs orbiting dwarf stars. Unlike previous investigations, we consider both clear and cloudy sightlines from the SCISAT satellite. We find that the maximum difference in effective thickness of the atmosphere between a clear and globally cloudy atmosphere is 8.5 km at 2.28 microns with a resolution of 0.02 microns. After incorporating the effects of refraction and Pandexo's noise modeling, we find that JWST would not be able to detect Earth like stratospheric clouds if an exo-Earth was present in the TRAPPIST-1 system, as the cloud spectrum differs from the clear spectrum by a maximum of 10 ppm. These stratospheric clouds are also not robustly detected by TauREx when performing spectral retrieval for a cloudy TRAPPIST-1 planet. However, if an Earth size planet were to orbit in a white dwarf's habitable zone, then, we predict that JWST's NIRSpec would be able to detect its stratospheric clouds after only 4 transits. We conclude that stratospheric clouds would not impede JWST transit spectroscopy or the detection of biosignatures for Earth-like atmospheres., Comment: 12 pages, 6 figures, Accepted for publication in MNRAS
- Published
- 2022
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85. Information Theory to Probe Intrapartum Fetal Heart Rate Dynamics
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Carlos Granero-Belinchon, Stéphane G. Roux, Patrice Abry, Muriel Doret, and Nicolas B. Garnier
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n/a ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Intrapartum fetal heart rate (FHR) monitoring constitutes a reference tool in clinical practice to assess the baby’s health status and to detect fetal acidosis. It is usually analyzed by visual inspection grounded on FIGO criteria. Characterization of intrapartum fetal heart rate temporal dynamics remains a challenging task and continuously receives academic research efforts. Complexity measures, often implemented with tools referred to as approximate entropy (ApEn) or sample entropy (SampEn), have regularly been reported as significant features for intrapartum FHR analysis. We explore how information theory, and especially auto-mutual information (AMI), is connected to ApEn and SampEn and can be used to probe FHR dynamics. Applied to a large (1404 subjects) and documented database of FHR data, collected in a French academic hospital, it is shown that (i) auto-mutual information outperforms ApEn and SampEn for acidosis detection in the first stage of labor and continues to yield the best performance in the second stage; (ii) Shannon entropy increases as labor progresses and is always much larger in the second stage; (iii) babies suffering from fetal acidosis additionally show more structured temporal dynamics than healthy ones and that this progressive structuration can be used for early acidosis detection.
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- 2017
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86. Is gene transcription involved in seed dry after-ripening?
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Patrice Meimoun, Ernest Mordret, Nicolas B Langlade, Sandrine Balzergue, Sandrine Arribat, Christophe Bailly, and Hayat El-Maarouf-Bouteau
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Medicine ,Science - Abstract
Orthodox seeds are living organisms that survive anhydrobiosis and may display dormancy, an inability to germinate at harvest. Seed germination potential can be acquired during a prolonged period of dry storage called after-ripening. The aim of this work was to determine if gene transcription is an underlying regulatory mechanism for dormancy alleviation during after-ripening. To identify changes in gene transcription strictly associated with the acquisition of germination potential but not with storage, we used seed storage at low relative humidity that maintains dormancy as control. Transcriptome profiling was performed using DNA microarray to compare change in gene transcript abundance between dormant (D), after-ripened non-dormant (ND) and after-ripened dormant seeds (control, C). Quantitative real-time polymerase chain reaction (qPCR) was used to confirm gene expression. Comparison between D and ND showed the differential expression of 115 probesets at cut-off values of two-fold change (p
- Published
- 2014
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87. Genetic control of water use efficiency and leaf carbon isotope discrimination in sunflower (Helianthus annuus L.) subjected to two drought scenarios.
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Afifuddin Latif Adiredjo, Olivier Navaud, Stephane Muños, Nicolas B Langlade, Thierry Lamaze, and Philippe Grieu
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Medicine ,Science - Abstract
High water use efficiency (WUE) can be achieved by coordination of biomass accumulation and water consumption. WUE is physiologically and genetically linked to carbon isotope discrimination (CID) in leaves of plants. A population of 148 recombinant inbred lines (RILs) of sunflower derived from a cross between XRQ and PSC8 lines was studied to identify quantitative trait loci (QTL) controlling WUE and CID, and to compare QTL associated with these traits in different drought scenarios. We conducted greenhouse experiments in 2011 and 2012 by using 100 balances which provided a daily measurement of water transpired, and we determined WUE, CID, biomass and cumulative water transpired by plants. Wide phenotypic variability, significant genotypic effects, and significant negative correlations between WUE and CID were observed in both experiments. A total of nine QTL controlling WUE and eight controlling CID were identified across the two experiments. A QTL for phenotypic response controlling WUE and CID was also significantly identified. The QTL for WUE were specific to the drought scenarios, whereas the QTL for CID were independent of the drought scenarios and could be found in all the experiments. Our results showed that the stable genomic regions controlling CID were located on the linkage groups 06 and 13 (LG06 and LG13). Three QTL for CID were co-localized with the QTL for WUE, biomass and cumulative water transpired. We found that CID and WUE are highly correlated and have common genetic control. Interestingly, the genetic control of these traits showed an interaction with the environment (between the two drought scenarios and control conditions). Our results open a way for breeding higher WUE by using CID and marker-assisted approaches and therefore help to maintain the stability of sunflower crop production.
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- 2014
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88. Deep two-phase, hemispherical magma oceans on lava planets
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Boukaré, Charles-Édouard, Cowan, Nicolas B., and Badro, James
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Geophysics - Abstract
Astronomers have discovered a handful of exoplanets with rocky bulk compositions but orbiting so close to their host star that the surface of the planet must be at least partially molten. It is expected that the dayside of such "lava planets" harbors a rock vapor atmosphere that flows quickly towards the airless nightside -- this partial atmosphere is critical to the interpretation of lava planet observations, but transports negligible heat towards the nightside. As a result, the surface temperature of the magma ocean may range from 3000~K near the sub-stellar point down to 1500~K near the day-night terminator. We use simple models incorporating the thermodynamics and geochemistry of partial melt to predict the physical and chemical properties of the magma ocean as a function of the distance from the sub-stellar point. Our two principal findings are that 1) the dayside magma ocean is much deeper than previously thought, probably extending down to the core-mantle boundary in some locations, and 2) much of the dayside is only partially molten, leading to gradients in the surface chemistry of the magma ocean. These findings have important implications for the dynamics of the magma ocean as well as the composition and dynamics of the atmosphere., Comment: 16 pages, 5 figures. Resubmitted to ApJ after revision
- Published
- 2022
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89. The impact of ultraviolet heating and cooling on the dynamics and observability of lava planet atmospheres
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Nguyen, T. Giang, Cowan, Nicolas B., Pierrehumbert, Raymond T., Lupu, Roxana E., and Moores, John E.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
Lava planets have non-global, condensible atmospheres similar to icy bodies within the solar system. Because they depend on interior dynamics, studying the atmospheres of lava planets can lead to understanding unique geological processes driven by their extreme environment. Models of lava planet atmospheres have thus far focused on either radiative transfer or hydrodynamics. In this study, we couple the two processes by introducing ultraviolet and infrared radiation to a turbulent boundary layer model. We also test the effect of different vertical temperature profiles on atmospheric dynamics. Results from the model show that UV radiation affects the atmosphere much more than IR. UV heating and cooling work together to produce a horizontally isothermal atmosphere away from the sub-stellar point regardless of the vertical temperature profile. We also find that stronger temperature inversions induce stronger winds and hence cool the atmosphere. Our simulated transmission spectra of the bound atmosphere show a strong SiO feature in the UV that would be challenging to observe in the planet's transit spectrum due to the precision required. Our simulated emission spectra are more promising, with significant SiO spectral features at 4.5 and 9 $\mu$m that can be observed with the James Webb Space Telescope. Different vertical temperature profiles produce discernible dayside emission spectra, but not in the way one would expect., Comment: Accepted to MNRAS
- Published
- 2022
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90. Transit Time Estimation in Catchments: Recent Developments and Future Directions
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Benettin, Paolo, Rodriguez, Nicolas B, Sprenger, Matthias, Kim, Minseok, Klaus, Julian, Harman, Ciaran J, van der Velde, Ype, Hrachowitz, Markus, Botter, Gianluca, McGuire, Kevin J, Kirchner, James W, Rinaldo, Andrea, and McDonnell, Jeffrey J
- Subjects
Hydrology ,Earth Sciences ,transit time ,water age ,catchment ,review ,transport ,tracer ,Physical Geography and Environmental Geoscience ,Civil Engineering ,Environmental Engineering ,Civil engineering ,Environmental engineering - Abstract
Water transit time is now a standard measure in catchment hydrological and ecohydrological research. The last comprehensive review of transit time modeling approaches was published 15+ years ago. But since then the field has largely expanded with new data, theory and applications. Here, we review these new developments with focus on water-age-balance approaches and data-based approaches. We discuss and compare methods including StorAge-Selection functions, well/partially mixed compartments, water age tracking through spatially distributed models, direct transit time estimates from controlled experiments, young water fractions, and ensemble hydrograph separation. We unify some of the heterogeneity in the literature that has crept in with these many new approaches, in an attempt to clarify the key differences and similarities among them. Finally, we point to open questions in transit time research, including what we still need from theory, models, field work, and community practice.
- Published
- 2022
91. Two-dimensional structure functions to characterize convective rolls in the marine atmospheric boundary layer from Sentinel-1 SAR images
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Granero-Belinchon, Carlos, Roux, Stéphane G., Garnier, Nicolas B., Tandeo, Pierre, Bertrand, Chapron, and Mouche, Alexis
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Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing ,Physics - Atmospheric and Oceanic Physics ,Physics - Data Analysis, Statistics and Probability ,Physics - Fluid Dynamics - Abstract
We study the shape of convective rolls in the Marine Atmospheric Boundary Layer from Synthetic Aperture Radar images of the ocean. We propose a multiscale analysis with structure functions which allow an easy generalization to analyse high-order statistics and so to finely describe the shape of the rolls. The two main results are : 1) second order structure function characterizes the size and direction of rolls just like correlation or power spectrum do, 2) high order statistics can be studied with skewness and Flatness which characterize the asymmetry and intermittency of rolls respectively. From the best of our knowledge, this is the first time that the asymmetry and intermittency of rolls is shown from radar images of the ocean surface.
- Published
- 2022
92. Mapping the Surface of Partially Cloudy Exoplanets is Hard
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Teinturier, Lucas, Vieira, Nicholas, Jacquet, Elisa, Geoffrion, Juliette, Bestavros, Youssef, Keating, Dylan, and Cowan, Nicolas B.
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Reflected light photometry of terrestrial exoplanets could reveal the presence of oceans and continents, hence placing direct constraints on the current and long-term habitability of these worlds. Inferring the albedo map of a planet from its observed light curve is challenging because different maps may yield indistinguishable light curves. This degeneracy is aggravated by changing clouds. It has previously been suggested that disk-integrated photometry spanning multiple days could be combined to obtain a cloud-free surface map of an exoplanet. We demonstrate this technique as part of a Bayesian retrieval by simultaneously fitting for the fixed surface map of a planet and the time-variable overlying clouds. We test this approach on synthetic data then apply it to real disk-integrated observations of the Earth. We find that eight days of continuous synthetic observations are sufficient to reconstruct a faithful low resolution surface albedo map, without needing to make assumptions about cloud physics. For lightcurves with negligible photometric uncertainties, the minimal top-of-atmosphere albedo at a location is a good estimate of its surface albedo. When applied to observations from the Earth Polychromating Imaging Camera aboard the DSCOVR spacecraft, our approach removes only a small fraction of clouds. We attribute this difficulty to the full-phase geometry of observations combined with the short correlation length for Earth clouds. For exoplanets with Earth-like climatology, it may be hard to do much better than a cloud-averaged map. We surmise that cloud removal will be most successful for exoplanets imaged near quarter phase that harbour large cloud systems., Comment: 9 pages, 3 figures To be published in MNRAS
- Published
- 2022
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93. Quantifying Non-Stationarity with Information Theory
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Granero-Belinchon, Carlos, Roux, Stéphane G., and Garnier, Nicolas B.
- Subjects
Physics - Data Analysis, Statistics and Probability ,Physics - Fluid Dynamics - Abstract
We introduce an index based on information theory to quantify the stationarity of a stochastic process.The index compares on the one hand the information contained in the increment at the time scale $\tau$ of the process at time $t$ with, on the other hand, the extra information in the variable at time $t$ that is not present at time $t-\tau$. By varying the scale $\tau$, the index can explore a full range of scales. We thus obtain a multi-scale quantity that is not restricted to the first two moments of the density distribution, nor to the covariance, but that probes the complete dependences in the process. This index indeed provides a measure of the regularity of the process at a given scale.Not only is this index able to indicate whether a realization of the process is stationary, but its evolution across scales also indicates how rough and non-stationary it is.We show how the index behaves for various synthetic processes proposed to model fluid turbulence, as well as on experimental fluid turbulence measurements., Comment: Entropy, MDPI, 2021
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- 2021
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94. A gene-phenotype network based on genetic variability for drought responses reveals key physiological processes in controlled and natural environments.
- Author
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David Rengel, Sandrine Arribat, Pierre Maury, Marie-Laure Martin-Magniette, Thibaut Hourlier, Marion Laporte, Didier Varès, Sébastien Carrère, Philippe Grieu, Sandrine Balzergue, Jérôme Gouzy, Patrick Vincourt, and Nicolas B Langlade
- Subjects
Medicine ,Science - Abstract
Identifying the connections between molecular and physiological processes underlying the diversity of drought stress responses in plants is key for basic and applied science. Drought stress response involves a large number of molecular pathways and subsequent physiological processes. Therefore, it constitutes an archetypical systems biology model. We first inferred a gene-phenotype network exploiting differences in drought responses of eight sunflower (Helianthus annuus) genotypes to two drought stress scenarios. Large transcriptomic data were obtained with the sunflower Affymetrix microarray, comprising 32423 probesets, and were associated to nine morpho-physiological traits (integrated transpired water, leaf transpiration rate, osmotic potential, relative water content, leaf mass per area, carbon isotope discrimination, plant height, number of leaves and collar diameter) using sPLS regression. Overall, we could associate the expression patterns of 1263 probesets to six phenotypic traits and identify if correlations were due to treatment, genotype and/or their interaction. We also identified genes whose expression is affected at moderate and/or intense drought stress together with genes whose expression variation could explain phenotypic and drought tolerance variability among our genetic material. We then used the network model to study phenotypic changes in less tractable agronomical conditions, i.e. sunflower hybrids subjected to different watering regimes in field trials. Mapping this new dataset in the gene-phenotype network allowed us to identify genes whose expression was robustly affected by water deprivation in both controlled and field conditions. The enrichment in genes correlated to relative water content and osmotic potential provides evidence of the importance of these traits in agronomical conditions.
- Published
- 2012
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95. Early T cell signalling is reversibly altered in PD-1+ T lymphocytes infiltrating human tumors.
- Author
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Shu-Fang Wang, Stéphane Fouquet, Maxime Chapon, Hélène Salmon, Fabienne Regnier, Karine Labroquère, Cécile Badoual, Diane Damotte, Pierre Validire, Eve Maubec, Nicolas B Delongchamps, Aurélie Cazes, Laure Gibault, Marylène Garcette, Marie-Caroline Dieu-Nosjean, Marc Zerbib, Marie-Françoise Avril, Armelle Prévost-Blondel, Clotilde Randriamampita, Alain Trautmann, and Nadège Bercovici
- Subjects
Medicine ,Science - Abstract
To improve cancer immunotherapy, a better understanding of the weak efficiency of tumor-infiltrating T lymphocytes (TIL) is necessary. We have analyzed the functional state of human TIL immediately after resection of three types of tumors (NSCLC, melanoma and RCC). Several signalling pathways (calcium, phosphorylation of ERK and Akt) and cytokine secretion are affected to different extents in TIL, and show a partial spontaneous recovery within a few hours in culture. The global result is an anergy that is quite distinct from clonal anergy induced in vitro, and closer to adaptive tolerance in mice. PD-1 (programmed death -1) is systematically expressed by TIL and may contribute to their anergy by its mere expression, and not only when it interacts with its ligands PD-L1 or PD-L2, which are not expressed by every tumor. Indeed, the TCR-induced calcium and ERK responses were reduced in peripheral blood T cells transfected with PD-1. Inhibition by sodium stibogluconate of the SHP-1 and SHP-2 phosphatases that associate with several inhibitory receptors including PD-1, relieves part of the anergy apparent in TIL or in PD-1-transfected T cells. This work highlights some of the molecular modifications contributing to functional defects of human TIL.
- Published
- 2011
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- View/download PDF
96. Thermal Phase Curves of XO-3b: an Eccentric Hot Jupiter at the Deuterium Burning Limit
- Author
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Dang, Lisa, Bell, Taylor J., Cowan, Nicolas B., Thorngren, Daniel, Kataria, Tiffany, Knutson, Heather A., Lewis, Nikole K., Stassun, Keivan G., Fortney, Jonathan J., Agol, Eric, Laughlin, Gregory P., Burrows, Adam, Collins, Karen A., Deming, Drake, Jovmir, Diana, Langton, Jonathan, Rastegar, Sara, and Showman, Adam P.
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We report \textit{Spitzer} full-orbit phase observations of the eccentric hot Jupiter XO-3b at 3.6 and 4.5 $\mu$m. Our new eclipse depth measurements of $1770 \pm 180$ ppm at 3.6 $\mu$m and $1610 \pm 70$ ppm at 4.5 $\mu$m show no evidence of the previously reported dayside temperature inversion. We also empirically derive the mass and radius of XO-3b and its host star using Gaia DR3's parallax measurement and find a planetary mass $M_p=11.79 \pm 0.98 ~M_{\rm{Jup}}$ and radius $R_p=1.295 \pm 0.066 ~R_{\rm{Jup}}$. We compare our \textit{Spitzer} observations with multiple atmospheric models to constrain the radiative and advective properties of XO-3b. While the decorrelated 4.5 $\mu$m observations are pristine, the 3.6 $\mu$m phase curve remains polluted with detector systematics due to larger amplitude intrapixel sensitivity variations in this channel. We focus our analysis on the more reliable 4.5 $\mu$m phase curve and fit an energy balance model with solid body rotation to estimate the zonal wind speed and the pressure of the bottom of the mixed layer. Our energy balance model fit suggests an eastward equatorial wind speed of $3.13 ^{+0.26} _{-0.83}$ km/s, an atmospheric mixed layer down to $2.40 ^{+0.92} _{-0.16}$ bar, and Bond albedo of $0.106 ^{+0.008} _{-0.106}$. We assume that the wind speed and mixed layer depth are constant throughout the orbit. We compare our observations with a 1D planet-averaged model predictions at apoapse and periapse and 3D general circulation model (GCM) predictions for XO-3b. We also investigate the inflated radius of XO-3b and find that it would require an unusually large amount of internal heating to explain the observed planetary radius., Comment: 23 pages, 14 figures, accepted for publication in AJ
- Published
- 2021
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97. Using the Climate App to learn about Planetary Habitability and Climate Change
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Zhu, Lan Xi, Courchesne, Anthony, and Cowan, Nicolas B.
- Subjects
Physics - Physics Education ,Astrophysics - Earth and Planetary Astrophysics ,Physics - Atmospheric and Oceanic Physics - Abstract
Simple climate models have been around for more than a century but have recently come back into fashion: they are useful for explaining global warming and the habitability of extrasolar planets. The Climate App (https://www.climateapp.ca) is an interactive web-based application that describes the radiative transfer governing planetary climate. The App is currently available in French and English and is suitable for teaching high-school through college students, or public outreach. The beginner version can be used to explore the greenhouse effect and planetary albedo, sufficient for explaining anthropogenic climate change, the Faint Young Sun Paradox, the habitability of TRAPPIST planets and other simple scenarios. There is also an advanced option with more atmospheric layers and incorporating the absorption and scattering of shortwave radiation for students and educators wishing a deeper dive into atmospheric radiative transfer. A number of pedagogical activities are being beta tested and rolled out., Comment: 8 pages, 4 figures. A summarized version is included in International Astronomical Union CAP2021 conference proceedings
- Published
- 2021
98. Tinkering with the C-function: a molecular frame for the selection of double flowers in cultivated roses.
- Author
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Annick Dubois, Olivier Raymond, Marion Maene, Sylvie Baudino, Nicolas B Langlade, Véronique Boltz, Philippe Vergne, and Mohammed Bendahmane
- Subjects
Medicine ,Science - Abstract
BACKGROUND: Roses have been cultivated for centuries and a number of varieties have been selected based on flower traits such as petal form, color, and number. Wild-type roses have five petals (simple flowers), whereas high numbers of petals (double flowers) are typical attributes of most of the cultivated roses. Here, we investigated the molecular mechanisms that could have been selected to control petal number in roses. METHODOLOGY/PRINCIPAL FINDINGS: We have analyzed the expression of several candidate genes known to be involved in floral organ identity determination in roses from similar genetic backgrounds but exhibiting contrasting petal numbers per flower. We show that the rose ortholog of AGAMOUS (RhAG) is differentially expressed in double flowers as compared to simple flowers. In situ hybridization experiments confirm the differential expression of RhAG and demonstrate that in the double-flower roses, the expression domain of RhAG is restricted toward the center of the flower. Conversely, in simple-flower roses, RhAG expression domain is wider. We further show that the border of RhAG expression domain is labile, which allows the selection of rose flowers with increased petal number. Double-flower roses were selected independently in the two major regions for domestication, China and the peri-Mediterranean areas. Comparison of RhAG expression in the wild-type ancestors of cultivated roses and their descendants both in the European and Chinese lineages corroborates the correlation between the degree of restriction of RhAG expression domain and the number of petals. Our data suggests that a restriction of RhAG expression domain is the basis for selection of double flowers in both the Chinese and peri-Mediterranean centers of domestication. CONCLUSIONS/SIGNIFICANCE: We demonstrate that a shift in RhAG expression domain boundary occurred in rose hybrids, causing double-flower phenotype. This molecular event was selected independently during rose domestication in Europe/Middle East and in China.
- Published
- 2010
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99. The whys and wherefores of home creativity support: A cross-cultural reflexive thematic analysis between British and French parents
- Author
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Verger, Nicolas B., Roberts, Julie, Guiller, Jane, and McAloney-Kocaman, Kareena
- Published
- 2024
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100. BRAFV600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism
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Rzasa, Paulina, Whelan, Sarah, Farahmand, Pooyeh, Cai, Hong, Guterman, Inna, Palacios-Gallego, Raquel, Undru, Shanthi S., Sandford, Lauren, Green, Caleb, Andreadi, Catherine, Mintseva, Maria, Parrott, Emma, Jin, Hong, Hey, Fiona, Giblett, Susan, Sylvius, Nicolas B., Allcock, Natalie S., Straatman-Iwanowska, Anna, Feuda, Roberto, Tufarelli, Cristina, Brown, Karen, Pritchard, Catrin, and Rufini, Alessandro
- Published
- 2023
- Full Text
- View/download PDF
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