768 results on '"Niccoli P"'
Search Results
52. Sunitinib for metastatic progressive phaeochromocytomas and paragangliomas: results from FIRSTMAPPP, an academic, multicentre, international, randomised, placebo-controlled, double-blind, phase 2 trial
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Baudin, E., Goichot, B., Berruti, A., Hadoux, J., Moalla, S., Laboureau, S., Nölting, S., Fouchardière, C. de la, Kienitz, T., Deutschbein, T., Zovato, S., Amar, L., Haissaguerre, M., Timmers, H.J.L.M., Niccoli, P., Faggiano, A., Angokai, M., Lamartina, L., Luca, F., Cosentini, D., Hahner, S., Beuschlein, F., Attard, M., Texier, M., Fassnacht, M., Baudin, E., Goichot, B., Berruti, A., Hadoux, J., Moalla, S., Laboureau, S., Nölting, S., Fouchardière, C. de la, Kienitz, T., Deutschbein, T., Zovato, S., Amar, L., Haissaguerre, M., Timmers, H.J.L.M., Niccoli, P., Faggiano, A., Angokai, M., Lamartina, L., Luca, F., Cosentini, D., Hahner, S., Beuschlein, F., Attard, M., Texier, M., and Fassnacht, M.
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Contains fulltext : 304834.pdf (Publisher’s version ) (Closed access), BACKGROUND: No randomised controlled trial has ever been done in patients with metastatic phaeochromocytomas and paragangliomas. Preclinical and first clinical evidence suggested beneficial effects of sunitinib. We aimed to evaluate the safety and efficacy of sunitinib in patients with metastatic phaeochromocytomas and paragangliomas. METHODS: FIRSTMAPPP is a multicentre, international, randomised, placebo-controlled, double-blind, phase 2 trial done at 14 academic centres across four European countries. Eligible participants were adults (aged ≥18 years) with sporadic or inherited progressive metastatic phaeochromocytomas and paragangliomas. Patients were randomly assigned (1:1) to receive either oral sunitinib (37·5 mg per day) or placebo. Randomisation was stratified according to SDHB status (mutation present vs wild type) and number of previous systemic therapies (0 vs ≥1). Primary endpoint was the rate of progression-free survival at 12 months according to real-time central review (Response Evaluation Criteria in Solid Tumours version 1.1). On the basis of a two-step Simon model, we aimed for the accrual of 78 patients, assuming a 20% improvement of the 12-month progression-free survival rate from 20% to 40%, to conclude that sunitinib is effective. Crossover from the placebo group was allowed. This trial is registered with ClinicalTrials.gov, number NCT01371201, and is closed for enrolment. FINDINGS: From Dec 1, 2011, to Jan 31, 2019, a total of 78 patients with progressive metastatic phaeochromocytomas and paragangliomas were enrolled (39 patients per group). 25 (32%) of 78 patients had germline SDHx variants and 54 (69%) had used previous therapies. The primary endpoint was met, with a 12-month progression-free survival in 14 of 39 patients (36% [90% CI 23-50]) in the sunitinib group. In the placebo group, the 12-month progression-free survival in seven of 39 patients was 19% (90% CI 11-31), validating the hypotheses of our study design. The most frequent gra
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- 2024
53. Prognostic Impact of Coronary Flow Reserve in Patients With Reduced Left Ventricular Ejection Fraction
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Hyun Sung Joh, Doosup Shin, Joo Myung Lee, Seung Hun Lee, David Hong, Ki Hong Choi, Doyeon Hwang, Coen K. M. Boerhout, Guus A. de Waard, Ji‐Hyun Jung, Hernan Mejia‐Renteria, Masahiro Hoshino, Mauro Echavarria‐Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera‐Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon‐Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Hyun Kuk Kim, Chang‐Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun‐Seok Shin, Steven A. J. Chamuleau, Niels van Royen, Paul Knaapen, Bon Kwon Koo, Tsunekazu Kakuta, Javier Escaned, Jan J. Piek, and Tim P. van de Hoef
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coronary flow reserve ,coronary physiology ,left ventricular ejection fraction ,prognosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Intracoronary physiologic indexes such as coronary flow reserve (CFR) and left ventricular ejection fraction (LVEF) have been regarded as prognostic indicators in patients with coronary artery disease. The current study evaluated the association between intracoronary physiologic indexes and LVEF and their differential prognostic implications in patients with coronary artery disease. Methods and Results A total of 1889 patients with 2492 vessels with available CFR and LVEF were selected from an international multicenter prospective registry. Baseline physiologic indexes were measured by thermodilution or Doppler methods and LVEF was recorded at the index procedure. The primary outcome was target vessel failure, which was a composite of cardiac death, target vessel myocardial infarction, or clinically driven target vessel revascularization over 5 years of follow‐up. Patients with reduced LVEF
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- 2022
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54. The 8-vertex model with quasi-periodic boundary conditions
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Niccoli, G. and Terras, V.
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Mathematical Physics ,Condensed Matter - Statistical Mechanics ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We study the inhomogeneous 8-vertex model (or equivalently the XYZ Heisenberg spin-1/2 chain) with all kinds of integrable quasi-periodic boundary conditions: periodic, $\sigma^x$-twisted, $\sigma^y$-twisted or $\sigma^z$-twisted. We show that in all these cases but the periodic one with an even number of sites $\mathsf{N}$, the transfer matrix of the model is related, by the vertex-IRF transformation, to the transfer matrix of the dynamical 6-vertex model with antiperiodic boundary conditions, which we have recently solved by means of Sklyanin's Separation of Variables (SOV) approach. We show moreover that, in all the twisted cases, the vertex-IRF transformation is bijective. This allows us to completely characterize, from our previous results on the antiperiodic dynamical 6-vertex model, the twisted 8-vertex transfer matrix spectrum (proving that it is simple) and eigenstates. We also consider the periodic case for $\mathsf{N}$ odd. In this case we can define two independent vertex-IRF transformations, both not bijective, and by using them we show that the 8-vertex transfer matrix spectrum is doubly degenerate, and that it can, as well as the corresponding eigenstates, also be completely characterized in terms of the spectrum and eigenstates of the dynamical 6-vertex antiperiodic transfer matrix. In all these cases we can adapt to the 8-vertex case the reformulations of the dynamical 6-vertex transfer matrix spectrum and eigenstates that had been obtained by $T$-$Q$ functional equations, where the $Q$-functions are elliptic polynomials with twist-dependent quasi-periods. Such reformulations enables one to characterize the 8-vertex transfer matrix spectrum by the solutions of some Bethe-type equations, and to rewrite the corresponding eigenstates as the multiple action of some operators on a pseudo-vacuum state, in a similar way as in the algebraic Bethe ansatz framework., Comment: 35 pages
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- 2015
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55. Antiperiodic dynamical 6-vertex model by separation of variables II: Functional equations and form factors
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Levy-Bencheton, D., Niccoli, G., and Terras, V.
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Mathematical Physics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We pursue our study of the antiperiodic dynamical 6-vertex model using Sklyanin's separation of variables approach, allowing in the model new possible global shifts of the dynamical parameter. We show in particular that the spectrum and eigenstates of the antiperiodic transfer matrix are completely characterized by a system of discrete equations. We prove the existence of different reformulations of this characterization in terms of functional equations of Baxter's type. We notably consider the homogeneous functional $T$-$Q$ equation which is the continuous analog of the aforementioned discrete system and show, in the case of a model with an even number of sites, that the complete spectrum and eigenstates of the antiperiodic transfer matrix can equivalently be described in terms of a particular class of its $Q$-solutions, hence leading to a complete system of Bethe equations. Finally, we compute the form factors of local operators for which we obtain determinant representations in finite volume., Comment: 52 pages
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- 2015
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56. On determinant representations of scalar products and form factors in the SoV approach: the XXX case
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Kitanine, N., Maillet, J. M., Niccoli, G., and Terras, V.
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Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
In the present article we study the form factors of quantum integrable lattice models solvable by the separation of variables (SoV) method. It was recently shown that these models admit universal determinant representations for the scalar products of the so-called separate states (a class which includes in particular all the eigenstates of the transfer matrix). These results permit to obtain simple expressions for the matrix elements of local operators (form factors). However, these representations have been obtained up to now only for the completely inhomogeneous versions of the lattice models considered. In this article we give a simple algebraic procedure to rewrite the scalar products (and hence the form factors) for the SoV related models as Izergin or Slavnov type determinants. This new form leads to simple expressions for the form factors in the homogeneous and thermodynamic limits. To make the presentation of our method clear, we have chosen to explain it first for the simple case of the $XXX$ Heisenberg chain with anti-periodic boundary conditions. We would nevertheless like to stress that the approach presented in this article applies as well to a wide range of models solved in the SoV framework., Comment: 46 pages
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- 2015
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57. The NLO jet vertex in the small-cone approximation for kt and cone algorithms
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Colferai, Dimitri and Niccoli, Alessandro
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High Energy Physics - Phenomenology - Abstract
We determine the jet vertex for Mueller-Navelet jets and forward jets in the small-cone approximation for two particular choices of jet algoritms: the kt algorithm and the cone algorithm. These choices are motivated by the extensive use of such algorithms in the phenomenology of jets. The differences with the original calculations of the small-cone jet vertex by Ivanov and Papa, which is found to be equivalent to a formerly algorithm proposed by Furman, are shown at both analytic and numerical level, and turn out to be sizeable. A detailed numerical study of the error introduced by the small-cone approximation is also presented, for various observables of phenomenological interest. For values of the jet "radius" R=0.5, the use of the small-cone approximation amounts to an error of about 5% at the level of cross section, while it reduces to less than 2% for ratios of distributions such as those involved in the measure of the azimuthal decorrelation of dijets., Comment: 22 pages, 7 figures, 13 eps files
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- 2015
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58. The Dark Side of the Exceptional: On Moral Exemplars, Character Education, and Negative Emotions
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Vaccarezza, Maria Silvia and Niccoli, Ariele
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This article focuses on negative exemplarity-related emotions (NEREs) and on their educational implications. In this article, we first argue for the nonexpendability of negative emotions broadly conceived by defending their instrumental and intrinsic role in a good and flourishing life. We make the claim more specific by focusing on the narrower domain of NEREs and argue for their moral and educational significance by evaluating whether they fit the arguments provided in the previous section. We go on to propose three educational strategies to foster NEREs' positive moral role. In conclusion, we point out that an exemplarist approach to character education would greatly benefit from a more fine-grained account of the emotions involved in the educational process and from a broader perspective on which of these emotions should be taken as valuable for educational purposes.
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- 2019
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59. Fatigue Crack Growth in Austenitic and Martensitic NiTi: Modeling and Experiments
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Sgambitterra, E., Magarò, P., Niccoli, F., Furgiuele, F., and Maletta, C.
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- 2021
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60. Maximizing Relayed 1H Hyperpolarization Transfer by Slow-Fast MAS NMR Spectroscopy.
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Badoni, Saumya, Berruyer, Pierrick, Niccoli, Lorenzo, Lesage, Anne, and Emsley, Lyndon
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- 2024
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61. Identification of the haemodynamic environment permissive for plaque erosion
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Michael McElroy, Yongcheol Kim, Giampaolo Niccoli, Rocco Vergallo, Alexander Langford-Smith, Filippo Crea, Frank Gijsen, Thomas Johnson, Amir Keshmiri, and Stephen J. White
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Medicine ,Science - Abstract
Abstract Endothelial erosion of atherosclerotic plaques is the underlying cause of approximately 30% of acute coronary syndromes (ACS). As the vascular endothelium is profoundly affected by the haemodynamic environment to which it is exposed, we employed computational fluid dynamic (CFD) analysis of the luminal geometry from 17 patients with optical coherence tomography (OCT)-defined plaque erosion, to determine the flow environment permissive for plaque erosion. Our results demonstrate that 15 of the 17 cases analysed occurred on stenotic plaques with median 31% diameter stenosis (interquartile range 28–52%), where all but one of the adherent thrombi located proximal to, or within the region of maximum stenosis. Consequently, all flow metrics related to elevated flow were significantly increased (time averaged wall shear stress, maximum wall shear stress, time averaged wall shear stress gradient) with a reduction in relative residence time, compared to a non-diseased reference segment. We also identified two cases that did not exhibit an elevation of flow, but occurred in a region exposed to elevated oscillatory flow. Our study demonstrates that the majority of OCT-defined erosions occur where the endothelium is exposed to elevated flow, a haemodynamic environment known to evoke a distinctive phenotypic response in endothelial cells.
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- 2021
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62. Clinical Relevance of Ischemia with Nonobstructive Coronary Arteries According to Coronary Microvascular Dysfunction
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Seung Hun Lee, Doosup Shin, Joo Myung Lee, Tim P. van de Hoef, David Hong, Ki Hong Choi, Doyeon Hwang, Coen K. M. Boerhout, Guus A. de Waard, Ji‐Hyun Jung, Hernan Mejia‐Renteria, Masahiro Hoshino, Mauro Echavarria‐Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera‐Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon‐Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Hyun Kuk Kim, Chang‐Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun‐Seok Shin, Steven A. J. Chamuleau, Niels van Royen, Paul Knaapen, Bon Kwon Koo, Tsunekazu Kakuta, Javier Escaned, and Jan J. Piek
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coronary flow reserve ,coronary microvascular disease ,ischemia with nonobstructive coronary arteries ,myocardial ischemia ,prognosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background In the absence of obstructive coronary stenoses, abnormality of noninvasive stress tests (NIT) in patients with chronic coronary syndromes may indicate myocardial ischemia of nonobstructive coronary arteries (INOCA). The differential prognosis of INOCA according to the presence of coronary microvascular dysfunction (CMD) and incremental prognostic value of CMD with intracoronary physiologic assessment on top of NIT information remains unknown. Methods and Results From the international multicenter registry of intracoronary physiologic assessment (ILIAS [Inclusive Invasive Physiological Assessment in Angina Syndromes] registry, N=2322), stable patients with NIT and nonobstructive coronary stenoses with fractional flow reserve >0.80 were selected. INOCA was diagnosed when patients showed positive NIT results. CMD was defined as coronary flow reserve ≤2.5. According to the presence of INOCA and CMD, patients were classified into 4 groups: group 1 (no INOCA nor CMD, n=116); group 2 (only CMD, n=90); group 3 (only INOCA, n=41); and group 4 (both INOCA and CMD, n=40). The primary outcome was major adverse cardiovascular events, a composite of all‐cause death, target vessel myocardial infarction, or clinically driven target vessel revascularization at 5 years. Among 287 patients with nonobstructive coronary stenoses (fractional flow reserve=0.91±0.06), 81 patients (38.2%) were diagnosed with INOCA based on positive NIT. By intracoronary physiologic assessment, 130 patients (45.3%) had CMD. Regardless of the presence of INOCA, patients with CMD showed a significantly lower coronary flow reserve and higher hyperemic microvascular resistance compared with patients without CMD (P
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- 2022
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63. Pasireotide for Refractory Hypoglycemia in Malignant Insulinoma- Case Report and Review of the Literature
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Sandrine Oziel-Taieb, Jemima Maniry-Quellier, Brice Chanez, Flora Poizat, Jacques Ewald, and Patricia Niccoli
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pasireotide ,refractory hypoglycemia ,neuroendocrine tumor ,pancreatic neuroendocrine cancer ,malignant insulinoma ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Malignant insulinomas are functional neuroendocrine tumors of the pancreas and the primary cause of tumor-related hypoglycemia. Malignant insulinoma is rare and has a poor prognosis. We report a case of metastatic malignant insulinoma in a 64-year-old female patient with severe and refractory hypoglycemia. After several ineffective locoregional and systemic therapeutic lines for the secretory disease, the introduction of pasireotide, a second-generation somatostatin analog, provided an improved clinical and secretory evolution both quickly and sustainably, with an excellent safety profile. Pasireotide is an effective and well-tolerated therapy in the treatment of refractory hypoglycemia in metastatic insulinoma.
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- 2022
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64. Antiperiodic XXZ chains with arbitrary spins: Complete eigenstate construction by functional equations in separation of variables
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Niccoli, G. and Terras, V.
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Mathematical Physics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
Generic inhomogeneous integrable XXZ chains with arbitrary spins are studied by means of the quantum separation of variables (SOV) method. Within this framework, a complete description of the spectrum (eigenvalues and eigenstates) of the antiperiodic transfer matrix is derived in terms of discrete systems of equations involving the inhomogeneity parameters of the model. We show here that one can reformulate this discrete SOV characterization of the spectrum in terms of functional T-Q equations of Baxter's type, hence proving the completeness of the solutions to the associated systems of Bethe-type equations. More precisely, we consider here two such reformulations. The first one is given in terms of Q-solutions, in the form of trigonometric polynomials of a given degree $N_s$, of a one-parameter family of T-Q functional equations with an extra inhomogeneous term. The second one is given in terms of Q-solutions, again in the form of trigonometric polynomials of degree $N_s$ but with double period, of Baxter's usual (i.e. without extra term) T-Q functional equation. In both cases, we prove the precise equivalence of the discrete SOV characterization of the transfer matrix spectrum with the characterization following from the consideration of the particular class of Q-solutions of the functional T-Q equation: to each transfer matrix eigenvalue corresponds exactly one such Q-solution and vice versa, and this Q-solution can be used to construct the corresponding eigenstate., Comment: 38 pages
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- 2014
65. Open spin chains with generic integrable boundaries: Baxter equation and Bethe ansatz completeness from SOV
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Kitanine, N., Maillet, J. -M., and Niccoli, G.
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Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We solve the longstanding problem to define a functional characterization of the spectrum of the transfer matrix associated to the most general spin-1/2 representations of the 6-vertex reflection algebra for general inhomogeneous chains. The corresponding homogeneous limit reproduces the spectrum of the Hamiltonian of the spin-1/2 open XXZ and XXX quantum chains with the most general integrable boundaries. The spectrum is characterized by a second order finite difference functional equation of Baxter type with an inhomogeneous term which vanishes only for some special but yet interesting non-diagonal boundary conditions. This functional equation is shown to be equivalent to the known separation of variable (SOV) representation hence proving that it defines a complete characterization of the transfer matrix spectrum. The polynomial character of the Q-function allows us then to show that a finite system of equations of generalized Bethe type can be similarly used to describe the complete transfer matrix spectrum., Comment: 28 pages
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- 2014
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66. A single-center experience with pancreatic cystic neuroendocrine tumors
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Ange Khalil, Jacques Ewald, Ugo Marchese, Aurélie Autret, Jonathan Garnier, Patricia Niccoli, Gilles Piana, Flora Poizat, Marc Giovannini, Jean-Robert Delpero, and Olivier Turrini
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Pancreatic neuroendocrine tumor ,Survival ,Cystic component ,Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Pancreatic neuroendocrine tumors (PNET) are rare, with a significant malignant potential. This study aimed to determine outcomes of patients with resected PNETs according to the cystic component and confirm the accuracy of preoperative staging. Methods From 1997 to 2016, 106 patients underwent resection of PNETs, including 73 purely solid (S-PNETs, 69%), 21 mixed (M-PNETs, 20%), and 12 purely cystic lesions (C-PNETs, 11%). To ensure consistent comparisons of overall (OS) and disease-free (DFS) survival outcomes between the 3 groups, the patients were matched according to the World Health Organization (WHO) grade and tumor height. Results Overall, the rate of correlation between the preoperative and pathological diagnoses was low in the C-PNET group (33%, P = 0.03). None of the 24 patients (23%) with metastatic disease at the time of surgery were in the C-PNET group. Furthermore, significantly more parenchyma-sparing resections (P = 0.039) and fewer enlarged resections (P = 0.019) were achieved in the C-PNET group. C-PNET group had a significantly lower node invasion rate than the S-PNET and M-PNET groups (8% vs. 41% and 24%, P = 0.004). Although median OS was comparable in all 3 groups before (P = 0.3) and after (P = 0.18) matching, higher median DFS was observed in the C-PNET group than in the other groups after matching (P = 0.038). Conclusion C-PNET was associated with a better prognosis than PNET with a solid component. The results support a wait-and-see policy in cases wherein a reliable preoperative diagnosis remains challenging.
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- 2020
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67. Therapeutic Potential of Ixekizumab in the Treatment of Ankylosing Spondylitis: A Review on the Emerging Clinical Data
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Benucci M, Damiani A, Li Gobbi F, Grossi V, Infantino M, Manfredi M, Niccoli L, and Cantini F
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ixekizumab ,ankylosing spondylitis ,randomized control trials ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Maurizio Benucci,1 Arianna Damiani,2 Francesca Li Gobbi,1 Valentina Grossi,3 Maria Infantino,3 Mariangela Manfredi,3 Laura Niccoli,4 Fabrizio Cantini4 1Rheumatology Unit, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, Florence, Italy; 2Rheumatology Unit, University of Florence, Florence, Italy; 3Immunology and Allergology Laboratory Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, Florence, Italy; 4Rheumatology Unit, S. Stefano Hospital, Azienda USL-Toscana Centro, Prato, ItalyCorrespondence: Maurizio BenucciRheumatology Unit, Azienda Sanitaria USL-Toscana Centro, Hospital S. Giovanni di Dio, Via Torregalli 3, Florence 50143, ItalyTel +39-055-6932636Fax +39-055-6932099Email maurizio.benucci@uslcentro.toscana.itAbstract: Over the last 20 years, the greatly improved knowledges of underlying pathogenic mechanisms of AS, including the role of tumor necrosis factor (TNF), the interleukin 23/Th17 axis, and interleukin-17 (Il-17), constituted the rationale to develop biologics selectively inhibiting these pathways. For more than 10 years, anti-TNF biologics were successfully employed to treat AS, with marked improvement of signs and symptoms in around 60% of the patients. Recent knowledge of the pathophysiology of spondyloarthritis has highlighted the emerging role of the IL-17/IL-23 axis. New therapies with selective biological drugs have emerged in the treatment of this pathology. In this review, we evaluated the effects of ixekizumab, a new anti–IL-17A, that was licensed both by EMA and FDA in August 2019 for the treatment of ankylosing spondylitis. The review highlights the efficacy and safety data of the 3 randomized controlled trials (COAST V-COAST W-COAST X) and those of the extension to 52 weeks of COAST V and COAST W.Keywords: ixekizumab, ankylosing spondylitis, randomized control trials
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- 2020
68. Ticagrelor and preconditioning in patients with stable coronary artery disease (TAPER-S): a randomized pilot clinical trial
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D. D’Amario, A. Restivo, A. M. Leone, R. Vergallo, S. Migliaro, F. Canonico, M. Galli, C. Trani, F. Burzotta, C. Aurigemma, G. Niccoli, A. Buffon, R. A. Montone, A. Flex, F. Franceschi, G. Tinelli, U. Limbruno, F. Francese, I. Ceccarelli, J. A. Borovac, I. Porto, and F. Crea
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Angina ,Ischemic preconditioning ,Ticagrelor ,Clopidogrel ,Adenosine ,Fractional flow reserve ,Medicine (General) ,R5-920 - Abstract
Abstract Background Ticagrelor is a reversibly binding, direct-acting, oral, P2Y12 antagonist used for the prevention of atherothrombotic events in patients with coronary artery disease (CAD). Ticagrelor blocks adenosine reuptake through the inhibition of equilibrative nucleoside transporter 1 (ENT-1) on erythrocytes and platelets, thereby facilitating adenosine-induced physiological responses such as an increase in coronary blood flow velocity. Meanwhile, adenosine plays an important role in triggering ischemic preconditioning through the activation of the A1 receptor. Therefore, an increase in ticagrelor-enhanced adenosine bioavailability may confer beneficial effects through mechanisms related to preconditioning activation and improvement of coronary microvascular dysfunction. Methods To determine whether ticagrelor can trigger ischemic preconditioning and influence microvascular function, we designed this prospective, open-label, pilot study that enrolled patients with stable multivessel CAD requiring staged, fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI). Participants will be randomized in 1:1 ratios either to ticagrelor (loading dose (LD) 180 mg, maintenance dose (MD) 90 mg bid) or to clopidogrel (LD 600 mg, MD 75 mg) from 3 to 1 days before the scheduled PCI. The PCI operators will be blinded to the randomization arm. The primary endpoint is the delta (difference) between ST segment elevations (in millimeters, mm) as assessed by intracoronary electrocardiogram (ECG) during the two-step sequential coronary balloon inflation in the culprit vessel. Secondary endpoints are 1) changes in coronary flow reserve (CFR), index of microvascular resistance (IMR), and FFR measured in the culprit vessel and reference vessel at the end of PCI, and 2) angina score during inflations. This study started in 2018 with the aim of enrolling 100 patients. Based on the rate of negative FFR up to 30% and a drop-out rate up to 10%, we expect to detect an absolute difference of 4 mm among the study arms in the mean change of ST elevation following repeated balloon inflations. All study procedures were reviewed and approved by the Ethical Committee of the Catholic University of Sacred Heart. Discussion Ticagrelor might improve ischemia tolerance and microvascular function compared to clopidogrel, and these effects might translate to better long-term clinical outcomes. Trial registration EudraCT No. 2016–004746-28. No. NCT02701140. Trial status Information provided in this manuscript refers to the definitive version (n. 3.0) of the study protocol, dated 31 October 2017, and includes all protocol amendments. Recruitment started on 18 September 2018 and is currently ongoing. The enrollment is expected to be completed by the end of 2019. Trial sponsor Fondazione Policlinico Universitario A. Gemelli – Roma, Polo di Scienze Cardiovascolari e Toraciche, Largo Agostino Gemelli 8, 00168 Rome, Italy.
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- 2020
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69. Frontotemporal Dementia and Glucose Metabolism
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Liam Rodney Garrett and Teresa Niccoli
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FTD ,glucose ,TDP-42 ,FUS ,MAPT ,C9orf72 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Frontotemporal dementia (FTD), hallmarked by antero-temporal degeneration in the human brain, is the second most common early onset dementia. FTD is a diverse disease with three main clinical presentations, four different identified proteinopathies and many disease-associated genes. The exact pathophysiology of FTD remains to be elucidated. One common characteristic all forms of FTD share is the dysregulation of glucose metabolism in patients’ brains. The brain consumes around 20% of the body’s energy supply and predominantly utilizes glucose as a fuel. Glucose metabolism dysregulation could therefore be extremely detrimental for neuronal health. Research into the association between glucose metabolism and dementias has recently gained interest in Alzheimer’s disease. FTD also presents with glucose metabolism dysregulation, however, this remains largely an unexplored area. A better understanding of the link between FTD and glucose metabolism may yield further insight into FTD pathophysiology and aid the development of novel therapeutics. Here we review our current understanding of FTD and glucose metabolism in the brain and discuss the evidence of impaired glucose metabolism in FTD. Lastly, we review research potentially suggesting a causal relationship between FTD proteinopathies and impaired glucose metabolism in FTD.
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- 2022
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70. Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review
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Cantini, Fabrizio, Goletti, Delia, Petrone, Linda, Najafi Fard, Saied, Niccoli, Laura, and Foti, Rosario
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- 2020
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71. The role of 18F-FDG PET/CT in endometrial adenocarcinoma: a review of the literature and recent advances
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Garau, Ludovico M., Niccoli-Asabella, Artor, Ferrari, Cristina, Sardaro, Angela, Pisani, Antonio, and Rubini, Giuseppe
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- 2020
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72. Clinical, angiographic and echocardiographic correlates of epicardial and microvascular spasm in patients with myocardial ischaemia and non-obstructive coronary arteries
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Montone, Rocco Antonio, Niccoli, Giampaolo, Russo, Michele, Giaccari, Marta, Del Buono, Marco Giuseppe, Meucci, Maria Chiara, Gurgoglione, Filippo, Vergallo, Rocco, D’Amario, Domenico, Buffon, Antonino, Leone, Antonio M., Burzotta, Francesco, Aurigemma, Cristina, Trani, Carlo, Liuzzo, Giovanna, Lanza, Gaetano A., and Crea, Filippo
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- 2020
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73. Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome
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Kim, Hyung Oh, Kim, Chong Jin, Kim, Weon, Cho, Jin-Man, Soeda, Tsunenari, Takano, Masamichi, Yan, Bryan P., Crea, Filippo, Niccoli, Giampaolo, Vergallo, Rocco, Minami, Yoshiyasu, Higuma, Takumi, Kimura, Shigeki, Boeder, Niklas Frederik, Nef, Holger, Adriaenssens, Tom, Kurihara, Osamu, Thondapu, Vikas, Russo, Michele, Yamamoto, Erika, Sugiyama, Tomoyo, Lee, Hang, Kakuta, Tsunekazu, Yonetsu, Taishi, and Jang, Ik-Kyung
- Published
- 2020
- Full Text
- View/download PDF
74. Self-similarity properties of nafionized and filtered water and deformed coherent states
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Capolupo, A., Del Giudice, E., Elia, V., Germano, R., Napoli, E., Niccoli, M., Tedeschi, A., and Vitiello, G.
- Subjects
Physics - General Physics - Abstract
By resorting to measurements of physically characterizing observables of water samples perturbed by the presence of Nafion and by iterative filtration processes, we discuss their scale free, self-similar fractal properties. By use of algebraic methods the isomorphism is proved between such self-similarity features and the deformed coherent state formalism., Comment: 20 pages, 3 figures. International Journal of Modern Physics B, to appear
- Published
- 2013
- Full Text
- View/download PDF
75. On the form factors of local operators in the Bazhanov-Stroganov and chiral Potts models
- Author
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Grosjean, N., Maillet, J. M., and Niccoli, G.
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We consider general cyclic representations of the 6-vertex Yang-Baxter algebra and analyze the associated quantum integrable systems, the Bazhanov-Stroganov model and the corresponding chiral Potts model on finite size lattices. We first determine the propagator operator in terms of the chiral Potts transfer matrices and we compute the scalar product of separate states (including the transfer matrix eigenstates) as a single determinant formulae in the framework of Sklyanin's quantum separation of variables. Then, we solve the quantum inverse problem and reconstruct the local operators in terms of the separate variables. We also determine a basis of operators whose form factors are characterized by a single determinant formulae. This implies that the form factors of any local operator are expressed as finite sums of determinants. Among these form factors written in determinant form are in particular those which will reproduce the chiral Potts order parameters in the thermodynamic limit., Comment: 45 pages
- Published
- 2013
- Full Text
- View/download PDF
76. SOV approach for integrable quantum models associated to general representations on spin-1/2 chains of the 8-vertex reflection algebra
- Author
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Faldella, S. and Niccoli, G.
- Subjects
Mathematical Physics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
The analysis of the transfer matrices associated to the most general representations of the 8-vertex reflection algebra on spin-1/2 chains is here implemented by introducing a quantum separation of variables (SOV) method which generalizes to these integrable quantum models the method first introduced by Sklyanin. More in detail, for the representations reproducing in their homogeneous limits the open XYZ spin-1/2 quantum chains with the most general integrable boundary conditions, we explicitly construct representations of the 8-vertex reflection algebras for which the transfer matrix spectral problem is separated. Then, in these SOV representations we get the complete characterization of the transfer matrix spectrum (eigenvalues and eigenstates) and its non-degeneracy. Moreover, we present the first fundamental step toward the characterization of the dynamics of these models by deriving determinant formulae for the matrix elements of the identity on separated states, which apply in particular to transfer matrix eigenstates. The comparison of our analysis for the 8-vertex reflection algebra with that of [1, 2] for the 6-vertex one leads to the interesting remark that a profound similarity in both the characterization of the spectral problems and of the scalar products exists for these two different realizations of the reflection algebra once they are described by SOV method. As it will be shown in a future publication, this remarkable similarity will be at the basis of the simultaneous determination of form factors of local operators of integrable quantum models associated to general reflection algebra representations of both 8-vertex and 6-vertex type., Comment: 37 pages
- Published
- 2013
- Full Text
- View/download PDF
77. Complete spectrum and scalar products for the open spin-1/2 XXZ quantum chains with non-diagonal boundary terms
- Author
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Faldella, S., Kitanine, N., and Niccoli, G.
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We use the quantum separation of variable (SOV) method to construct the eigenstates of the open XXZ chain with the most general boundary terms. The eigenstates in the inhomogeneous case are constructed in terms of solutions of a system of quadratic equations. This SOV representation permits us to compute scalar products and can be used to calculate form factors and correlation functions., Comment: 32 pages
- Published
- 2013
- Full Text
- View/download PDF
78. On the developments of Sklyanin's quantum separation of variables for integrable quantum field theories
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Niccoli, G.
- Subjects
Mathematical Physics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We present a microscopic approach in the framework of Sklyanin's quantum separation of variables (SOV) for the exact solution of 1+1-dimensional quantum field theories by integrable lattice regularizations. Sklyanin's SOV is the natural quantum analogue of the classical method of separation of variables and it allows a more symmetric description of classical and quantum integrability w.r.t. traditional Bethe ansatz methods. Moreover, it has the advantage to be applicable to a more general class of models for which its implementation gives a characterization of the spectrum complete by construction. Our aim is to introduce a method in this framework which allows at once to derive the spectrum (eigenvalues and eigenvectors) and the dynamics (time dependent correlation functions) of integrable quantum field theories (IQFTs). This approach is presented for a paradigmatic example of relativistic IQFT, the sine-Gordon model., Comment: 8 pages; invited contribution to the Proceedings of the XVIIth INTERNATIONAL CONGRESS ON MATHEMATICAL PHYSICS, August 2012, Aalborg, Danemark; accepted for publication on the ICMP12 Proceedings by World Scientific. The material here presented is strictly connected to that introduced in arXiv:0910.3173 and arXiv:1204.6307
- Published
- 2013
79. Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models
- Author
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Sharifah Anoar, Nathaniel S. Woodling, and Teresa Niccoli
- Subjects
Drosophila ,neurodegeneration ,mitochondria ,ALS ,FTD ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by declining motor and cognitive functions. Even though these diseases present with distinct sets of symptoms, FTD and ALS are two extremes of the same disease spectrum, as they show considerable overlap in genetic, clinical and neuropathological features. Among these overlapping features, mitochondrial dysfunction is associated with both FTD and ALS. Recent studies have shown that cells derived from patients’ induced pluripotent stem cells (iPSC)s display mitochondrial abnormalities, and similar abnormalities have been observed in a number of animal disease models. Drosophila models have been widely used to study FTD and ALS because of their rapid generation time and extensive set of genetic tools. A wide array of fly models have been developed to elucidate the molecular mechanisms of toxicity for mutations associated with FTD/ALS. Fly models have been often instrumental in understanding the role of disease associated mutations in mitochondria biology. In this review, we discuss how mutations associated with FTD/ALS disrupt mitochondrial function, and we review how the use of Drosophila models has been pivotal to our current knowledge in this field.
- Published
- 2021
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80. Identification of the haemodynamic environment permissive for plaque erosion
- Author
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McElroy, Michael, Kim, Yongcheol, Niccoli, Giampaolo, Vergallo, Rocco, Langford-Smith, Alexander, Crea, Filippo, Gijsen, Frank, Johnson, Thomas, Keshmiri, Amir, and White, Stephen J.
- Published
- 2021
- Full Text
- View/download PDF
81. The effects of exercise and active assisted cycle ergometry in post-operative total knee arthroplasty patients - a randomized controlled trial
- Author
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Sanzo, P., Niccoli, S., Droll, K., Puskas, D., Cullinan, C., and Lees, S. J.
- Published
- 2021
- Full Text
- View/download PDF
82. Antiperiodic dynamical 6-vertex model I: Complete spectrum by SOV, matrix elements of the identity on separate states and connections to the periodic 8-vertex model
- Author
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Niccoli, G.
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory - Abstract
The spin-1/2 highest weight representations of the dynamical 6-vertex and the standard 8-vertex Yang-Baxter algebra on a finite chain are considered in this paper. For the antiperiodic dynamical 6-vertex transfer matrix defined on chains with an odd number of sites, we adapt the Sklyanin's quantum separation of variable (SOV) method and explicitly construct SOV representations from the original space of representations. We provide the complete characterization of eigenvalues and eigenstates proving also the simplicity of its spectrum. Moreover, we characterize the matrix elements of the identity on separated states by determinant formulae. The matrices entering in these determinants have elements given by sums over the SOV spectrum of the product of the coefficients of separate states. This SOV analysis is not reduced to the case of the elliptic roots of unit and the results here derived define the required setup to extend to the dynamical 6-vertex model the approach recently developed in [1]-[5] to compute the form factors of the local operators in the SOV framework, these results will be presented in a future publication. For the periodic 8-vertex transfer matrix, we prove that its eigenvalues have to satisfy a fixed system of equations. In the case of a chain with an odd number of sites, this system of equations is the same entering in the SOV characterization of the antiperiodic dynamical 6-vertex transfer matrix spectrum. This implies that the set of the periodic 8-vertex eigenvalues is contained in the set of the antiperiodic dynamical 6-vertex eigenvalues. A criterion is introduced to find simultaneous eigenvalues of these two transfer matrices and associate to any of such eigenvalues one nonzero eigenstate of the periodic 8-vertex transfer matrix by using the SOV results. Moreover, a preliminary discussion on the degeneracy of the periodic 8-vertex spectrum is also presented., Comment: 36 pages, main modifications in section 3 and one appendix added, no result modified for the dynamical 6-vertex transfer matrix spectrum and the matrix elements of identity on separate states for chains with an odd number of sites
- Published
- 2012
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83. Form factors and complete spectrum of XXX antiperiodic higher spin chains by quantum separation of variables
- Author
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Niccoli, G.
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory - Abstract
The antiperiodic transfer matrix associated to higher spin representations of the rational 6-vertex Yang-Baxter algebra is analyzed by generalizing the approach introduced recently in [1], for the cyclic representations, in [2], for the spin-1/2 highest weight representations, and in [3], for the spin 1/2 representations of the reflection algebra. Here, we derive the complete characterization of the transfer matrix spectrum and we prove its simplicity in the framework of Sklyanin's quantum separation of variables (SOV). Then, the characterization of local operators by Sklyanin's quantum separate variables and the expression of the scalar products of separates states by determinant formulae allow to compute the form factors of the local spin operators by one determinant formulae similar to the scalar product ones. Finally, let us comment that these results represent the SOV analogous in the antiperiodic higher spin XXX quantum chains of the results obtained for the periodic chains in [4] in the framework of the algebraic Bethe ansatz., Comment: 20 pages, introduction improved by taking into account some relevant references on the spectrum of the model under general boundary conditions, no further relevant modifications
- Published
- 2012
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84. Non-diagonal open spin-1/2 XXZ quantum chains by separation of variables: Complete spectrum and matrix elements of some quasi-local operators
- Author
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Niccoli, G.
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory - Abstract
The integrable quantum models, associated to the transfer matrices of the 6-vertex reflection algebra for spin 1/2 representations, are studied in this paper. In the framework of Sklyanin's quantum separation of variables (SOV), we provide the complete characterization of the eigenvalues and eigenstates of the transfer matrix and the proof of the simplicity of the transfer matrix spectrum. Moreover, we use these integrable quantum models as further key examples for which to develop a method in the SOV framework to compute matrix elements of local operators. This method has been introduced first in [1] and then used also in [2], it is based on the resolution of the quantum inverse problem (i.e. the reconstruction of all local operators in terms of the quantum separate variables) plus the computation of the action of separate covectors on separate vectors. In particular, for these integrable quantum models, which in the homogeneous limit reproduce the open spin-1/2 XXZ quantum chains with non-diagonal boundary conditions, we have obtained the SOV-reconstructions for a class of quasi-local operators and determinant formulae for the covector-vector actions. As consequence of these findings we provide one determinant formulae for the matrix elements of this class of reconstructed quasi-local operators on transfer matrix eigenstates., Comment: 40 pages. Minor modifications in the text and some notations and some more reference added
- Published
- 2012
- Full Text
- View/download PDF
85. Antiperiodic spin-1/2 XXZ quantum chains by separation of variables: Complete spectrum and form factors
- Author
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Niccoli, G.
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory - Abstract
In this paper we consider the spin 1/2 highest weight representations for the 6-vertex Yang-Baxter algebra on a finite lattice and analyze the integrable quantum models associated to the antiperiodic transfer matrix. For these models, which in the homogeneous limit reproduces the XXZ spin 1/2 quantum chains with antiperiodic boundary conditions, we obtain in the framework of Sklyanin's quantum separation of variables (SOV) the following results: I) The complete characterization of the transfer matrix spectrum (eigenvalues/eigenstates) and the proof of its simplicity. II) The reconstruction of all local operators in terms of Sklyanin's quantum separate variables. III) One determinant formula for the scalar products of separates states, the elements of the matrix in the scalar product are sums over the SOV spectrum of the product of the coefficients of the states. IV) The form factors of the local spin operators on the transfer matrix eigenstates by a one determinant formula given by simple modifications of the scalar product formula., Comment: 29 pages
- Published
- 2012
- Full Text
- View/download PDF
86. The tau_2-model and the chiral Potts model revisited: completeness of Bethe equations from Sklyanin's SOV method
- Author
-
Grosjean, N. and Niccoli, G.
- Subjects
Mathematical Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory - Abstract
The most general cyclic representations of the quantum integrable tau_2-model are analyzed. The complete characterization of the tau_2-spectrum (eigenvalues and eigenstates) is achieved in the framework of Sklyanin's Separation of Variables (SOV) method by extending and adapting the ideas first introduced in [1, 2]: i) The determination of the tau_2-spectrum is reduced to the classification of the solutions of a given functional equation in a class of polynomials. ii) The determination of the tau_2-eigenstates is reduced to the classification of the solutions of an associated Baxter equation. These last solutions are proven to be polynomials for a quite general class of tau_2-self-adjoint representations and the completeness of the associated Bethe ansatz type equations is derived. Finally, the following results are derived for the inhomogeneous chiral Potts model: i) Simplicity of the spectrum, for general representations. ii) Complete characterization of the chiral Potts spectrum (eigenvalues and eigenstates) and completeness of Bethe ansatz type equations, for the self-adjoint representations of tau_2-model on the chiral Potts algebraic curves., Comment: 40 pages. Minor modifications in the text and some notations
- Published
- 2012
- Full Text
- View/download PDF
87. On the form factors of local operators in the lattice sine-Gordon model
- Author
-
Grosjean, N., Maillet, J. M., and Niccoli, G.
- Subjects
Mathematical Physics ,High Energy Physics - Theory ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We develop a method for computing form factors of local operators in the framework of Sklyanin's separation of variables (SOV) approach to quantum integrable systems. For that purpose, we consider the sine-Gordon model on a finite lattice and in finite dimensional cyclic representations as our main example. We first build our two central tools for computing matrix elements of local operators, namely, a generic determinant formula for the scalar products of states in the SOV framework and the reconstruction of local fields in terms of the separate variables. The general form factors are then obtained as sums of determinants of finite dimensional matrices, their matrix elements being given as weighted sums running over the separate variables and involving the Baxter Q-operator eigenvalues., Comment: 43 pages
- Published
- 2012
- Full Text
- View/download PDF
88. Maximizing Relayed 1H Hyperpolarization Transfer by Slow-Fast MAS NMR Spectroscopy
- Author
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Badoni, Saumya, Berruyer, Pierrick, Niccoli, Lorenzo, Lesage, Anne, and Emsley, Lyndon
- Abstract
1H-detected dynamic nuclear polarization (DNP)-enhanced fast magic angle spinning (MAS) NMR experiments provide unprecedented sensitivity to study the structure and dynamics in advanced materials and biomolecules. However, in relayed DNP experiments, DNP enhancements decrease with faster MAS rates, which is detrimental for sensitivity. The decrease is because 1H-1H spin diffusion rates are significantly reduced at fast MAS frequencies. To improve sensitivity at these fast MAS rates, here, we propose to combine fast polarization build-up by relay at slow MAS rate with high-resolution 1H NMR at fast MAS for acquisition. We perform experiments on l-histidine·HCl·H2O with MAS rates of up to 65 kHz using a 0.7 mm DNP probe at 18.8 T and 100 K. We obtain a 35% improvement in sensitivity in experiments where the sample is polarized at 20 kHz MAS and where the signal is acquired at 60 kHz MAS.
- Published
- 2024
- Full Text
- View/download PDF
89. Measurement and Computation of NbSn Rutherford Cables Strength Under Multi-Axial Loading Conditions<sub/>
- Author
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Vallone, G., Croteau, J.F., Anderssen, E., Bordini, B., D'Addazio, M., Ferracin, P., and Niccoli, F.
- Abstract
Superconducting magnet coils are subject to large thermo-mechanical loads applied during magnet assembly, cooldown and operation. These loads can cause the reduction of their critical current due to mechanical strains or local filament failures. Measurements on longitudinally stretched strands and Rutherford cables under transverse pressure have allowed exploration of material limits in two directions. However, no systematic study of the effect of multi-axial loading conditions has been done. Finite Element (FE) models show that, indeed, the actual limits of the material are strongly dependent on the nature of the applied load and that the strength under multi-axial loading can be significantly higher with respect to uniaxial loading conditions. In this paper, we try, for the first time, to measure the effect of multi-direction loading conditions on Nb
3 Sn Rutherford cables. The experiments are performed on impregnated cable stacks under transverse, lateral, and longitudinal constraints. The integrity of the cables is verified by destructive metallography inspection, evaluating the damage as a function of the applied loading condition.- Published
- 2024
- Full Text
- View/download PDF
90. Completeness of Bethe Ansatz by Sklyanin SOV for Cyclic Representations of Integrable Quantum Models
- Author
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Niccoli, G.
- Subjects
Mathematical Physics ,High Energy Physics - Theory - Abstract
In [1] an integrable quantum model was introduced and a class of its cyclic representations was proven to define lattice regularizations of the Sine-Gordon model. Here, we analyze general cyclic representations of this integrable quantum model by extending the spectrum construction introduced in [2] in the framework of the Separation of Variables (SOV) of Sklyanin. We show that as in [1] also for general representations, the transfer matrix spectrum (eigenvalues and eigenstates) is completely characterized in terms of polynomial solutions of an associated functional Baxter equation. Moreover, we prove that the method here developed has two fundamental built-in features: i) the completeness of the set of the transfer matrix eigenstates constructed from the solutions of the associated Bethe ansatz equations, ii) the existence and complete characterization of the Baxter Q-operator., Comment: 38 pages, two references added, minor modifications
- Published
- 2011
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91. Reconstruction of Baxter Q-operator from Sklyanin SOV for cyclic representations of integrable quantum models
- Author
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Niccoli, G.
- Subjects
High Energy Physics - Theory - Abstract
In [1], the spectrum (eigenvalues and eigenstates) of a lattice regularizations of the Sine-Gordon model has been completely characterized in terms of polynomial solutions with certain properties of the Baxter equation. This characterization for cyclic representations has been derived by the use of the Separation of Variables (SOV) method of Sklyanin and by the direct construction of the Baxter Q-operator family. Here, we reconstruct the Baxter Q-operator and the same characterization of the spectrum by only using the SOV method. This analysis allows us to deduce the main features required for the extension to cyclic representations of other integrable quantum models of this kind of spectrum characterization., Comment: 25 pages, Version published on Nucl.Phys. B; no formula changed, some references added together with Appendix B.
- Published
- 2009
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- View/download PDF
92. The Sine-Gordon model revisited I
- Author
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Niccoli, G. and Teschner, J.
- Subjects
High Energy Physics - Theory ,Mathematical Physics - Abstract
We study integrable lattice regularizations of the sine-Gordon model with the help of the separation of variables method of Sklyanin and the Baxter Q-operators. This leads us to the complete characterization of the spectrum (eigenvalues and eigenstates), in terms of the solutions to the Bethe ansatz equations. The completeness of the set of states that can be constructed from the solutions to the Bethe ansatz equations is proven by our approach., Comment: 44 pages, presentation improved, no result changed
- Published
- 2009
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- View/download PDF
93. Excimer Laser LEsion Modification to Expand Non-dilatable sTents: The ELLEMENT Registry
- Author
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Latib, Azeem, Takagi, Kensuke, Chizzola, Giuliano, Tobis, Jonathan, Ambrosini, Vittorio, Niccoli, Giampaolo, Sardella, Gennaro, DiSalvo, Maria Elena, Armigliato, Pietro, Valgimigli, Marco, Tarsia, Giandomenico, Gabrielli, Gabriele, Lazar, Lawrence, Maffeo, Diego, and Colombo, Antonio
- Subjects
Bioengineering ,Cardiovascular ,Heart Disease ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Assistive Technology ,Aged ,Aged ,80 and over ,Angioplasty ,Balloon ,Laser-Assisted ,Contrast Media ,Coronary Angiography ,Coronary Restenosis ,Coronary Stenosis ,Coronary Thrombosis ,Feasibility Studies ,Female ,Humans ,Italy ,Lasers ,Excimer ,Male ,Middle Aged ,Myocardial Infarction ,Pilot Projects ,Prospective Studies ,Prosthesis Design ,Registries ,Stents ,Time Factors ,Treatment Outcome ,Ultrasonography ,Interventional ,Vascular Calcification ,In-stent restenosis ,Excimer Laser Coronary Angioplasty ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
Background/objectivesStent underexpansion is a risk factor for in-stent restenosis and stent thrombosis. Existing techniques to optimize stent expansion are sometimes ineffective. The aim of this study was to evaluate the effectiveness and feasibility of Excimer Laser Coronary Angioplasty (ELCA) in improving stent expansion when high-pressure non-compliant balloon inflation was ineffective.Methods and resultsECLA ablation was performed at high energy during contrast injection and only within the underexpanded stent. The primary endpoint of successful laser dilatation was defined as an increase of at least 1mm(2) in minimal stent cross-sectional area (MSA) on IVUS or an increase of at least 20% in minimal stent diameter (MSD) by QCA, following redilatation with the same non-compliant balloon that had been unsuccessful prior to ELCA. Secondary endpoints were cardiac death, myocardial infarction (MI) and target lesion revascularization. Between June 2009 and November 2011, 28 patients with an underexpanded stent despite high-pressure balloon inflation were included. The mean laser catheter size was 1.2±0.4 (range 0.9-2.0mm) and a mean of 62±12mJ/mm(2) at 62±21hertz were required for optimal expansion. Laser-assisted stent dilatation was successful in 27 cases (96.4%), with an improvement in MSD by QCA (1.6±0.6mm at baseline to 2.6±0.6mm post-procedure) and MSA by IVUS (3.5±1.1mm(2) to 7.1±1.9mm(2)). Periprocedural MI occurred in 7.1%, transient slow-flow in 3.6% and ST elevation in 3.6%. During follow-up, there were no MIs, there was 1 cardiac-death, and TLR occurred in 6.7%.ConclusionsThe ELLEMENT study confirms the feasibility of ELCA with contrast injection to improve stent underexpansion in undilatable stented lesions.
- Published
- 2014
94. Results beyond 5-years of surgery or percutaneous approach in severe coronary disease. Reconstructed time-to-event meta-analysis of randomized trials.
- Author
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Formica, Francesco, Hernandez-Vaquero, Daniel, Tuttolomondo, Domenico, Gallingani, Alan, Singh, Gurmeet, Pattuzzi, Claudia, Niccoli, Giampaolo, Lorusso, Roberto, and Nicolini, Francesco
- Abstract
Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
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95. A general CFT model for antiferromagnetic spin-1/2 ladders with Mobius boundary conditions
- Author
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Cristofano, Gerardo, Marotta, Vincenzo, Naddeo, Adele, and Niccoli, Giuliano
- Subjects
High Energy Physics - Theory - Abstract
We show how the low-energy properties of the 2-leg XXZ spin-1/2 ladders with general anisotropy parameter $\Delta $ on closed geometries can be accounted for in the framework of the m-reduction procedure developed in [1]. In the limit of quasi-decoupled chains, a conformal field theory (CFT) with central charge c=2 is derived and its ability to describe the model with different boundary conditions is shown. Special emphasis is given to the Mobius boundary conditions which generate a topological defect corresponding to non trivial single-spinon excitations. Then, in the case of the 2-leg XXX ladders we discuss in detail the role of various perturbations in determining the renormalization group flow starting from the ultraviolet (UV) critical point with c=2., Comment: 23 pages, 5 figures; J. Stat. Mech.: Theory Exp. (2008), in print
- Published
- 2008
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96. Topologically protected qubits as minimal Josephson junction arrays with non trivial boundary conditions: a proposal
- Author
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Cristofano, Gerardo, Marotta, Vincenzo, Naddeo, Adele, and Niccoli, Giuliano
- Subjects
High Energy Physics - Theory ,Quantum Physics - Abstract
Recently a one-dimensional closed ladder of Josephson junctions has been studied (G. Cristofano et al., Phys. Lett. A 372 (2008) 2464) within a twisted conformal field theory (CFT) approach (G. Cristofano et al., Mod. Phys. Lett. A 15 (2000) 1679; Nucl. Phys. B 641 (2002) 547) and shown to develop the phenomenon of flux fractionalization (G. Cristofano et al., Eur. Phys. J. B 49 (2006) 83). That led us to predict the emergence of a topological order in such a system (G. Cristofano et al., JSTAT (2005) P03006). In this letter we analyze the ground states and the topological properties of fully frustrated Josephson junction arrays (JJA) arranged in a Corbino disk geometry for a variety of boundary conditions. In particular minimal configurations of fully frustrated JJA are considered and shown to exhibit the properties needed in order to build up a solid state qubit, protected from decoherence. The stability and transformation properties of the ground states of the JJA under adiabatic magnetic flux changes are analyzed in detail in order to provide a tool for the manipulation of the proposed qubit., Comment: 24 pages, 4 figures
- Published
- 2008
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97. FCC Physics Opportunities
- Author
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A. Abada, M. Abbrescia, S. S. AbdusSalam, I. Abdyukhanov, J. Abelleira Fernandez, A. Abramov, M. Aburaia, A. O. Acar, P. R. Adzic, P. Agrawal, J. A. Aguilar-Saavedra, J. J. Aguilera-Verdugo, M. Aiba, I. Aichinger, G. Aielli, A. Akay, A. Akhundov, H. Aksakal, J. L. Albacete, S. Albergo, A. Alekou, M. Aleksa, R. Aleksan, R. M. Alemany Fernandez, Y. Alexahin, R. G. Alía, S. Alioli, N. Alipour Tehrani, B. C. Allanach, P. P. Allport, M. Altınlı, W. Altmannshofer, G. Ambrosio, D. Amorim, O. Amstutz, L. Anderlini, A. Andreazza, M. Andreini, A. Andriatis, C. Andris, A. Andronic, M. Angelucci, F. Antinori, S. A. Antipov, M. Antonelli, M. Antonello, P. Antonioli, S. Antusch, F. Anulli, L. Apolinário, G. Apollinari, A. Apollonio, D. Appelö, R. B. Appleby, Ara. Apyan, Arm. Apyan, A. Arbey, A. Arbuzov, G. Arduini, V. Arı, S. Arias, N. Armesto, R. Arnaldi, S. A. Arsenyev, M. Arzeo, S. Asai, E. Aslanides, R. W. Aßmann, D. Astapovych, M. Atanasov, S. Atieh, D. Attié, B. Auchmann, A. Audurier, S. Aull, S. Aumon, S. Aune, F. Avino, G. Avrillaud, G. Aydın, A. Azatov, G. Azuelos, P. Azzi, O. Azzolini, P. Azzurri, N. Bacchetta, E. Bacchiocchi, H. Bachacou, Y. W. Baek, V. Baglin, Y. Bai, S. Baird, M. J. Baker, M. J. Baldwin, A. H. Ball, A. Ballarino, S. Banerjee, D. P. Barber, D. Barducci, P. Barjhoux, D. Barna, G. G. Barnaföldi, M. J. Barnes, A. Barr, J. Barranco García, J. Barreiro Guimarães da Costa, W. Bartmann, V. Baryshevsky, E. Barzi, S. A. Bass, A. Bastianin, B. Baudouy, F. Bauer, M. Bauer, T. Baumgartner, I. Bautista-Guzmán, C. Bayındır, F. Beaudette, F. Bedeschi, M. Béguin, I. Bellafont, L. Bellagamba, N. Bellegarde, E. Belli, E. Bellingeri, F. Bellini, G. Bellomo, S. Belomestnykh, G. Bencivenni, M. Benedikt, G. Bernardi, J. Bernardi, C. Bernet, J. M. Bernhardt, C. Bernini, C. Berriaud, A. Bertarelli, S. Bertolucci, M. I. Besana, M. Besançon, O. Beznosov, P. Bhat, C. Bhat, M. E. Biagini, J.-L. Biarrotte, A. Bibet Chevalier, E. R. Bielert, M. Biglietti, G. M. Bilei, B. 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Slavich, R. Slovak, V. Smaluk, V. Smirnov, W. Snoeys, L. Soffi, P. Sollander, O. Solovyanov, H. K. Soltveit, H. Song, P. Sopicki, M. Sorbi, L. Spallino, M. Spannowsky, B. Spataro, P. Sphicas, H. Spiesberger, P. Spiller, M. Spira, T. Srivastava, J. Stachel, A. Stakia, J. L. Stanyard, E. Starchenko, A. Yu. Starikov, A. M. Staśto, M. Statera, R. Steerenberg, J. Steggemann, A. Stenvall, F. Stivanello, D. Stöckinger, L. S. Stoel, M. Stöger-Pollach, B. Strauss, M. Stuart, G. Stupakov, S. Su, A. Sublet, K. Sugita, L. Sulak, M. K. Sullivan, S. Sultansoy, T. Sumida, K. Suzuki, G. Sylva, M. J. Syphers, A. Sznajder, M. Taborelli, N. A. Tahir, E. Tal Hod, M. Takeuchi, C. Tambasco, J. Tanaka, K. Tang, I. Tapan, S. Taroni, G. F. Tartarelli, G. Tassielli, L. Tavian, T. M. Taylor, G. N. Taylor, A. M. Teixeira, G. Tejeda-Muñoz, V. I. Telnov, R. Tenchini, H. H. J. ten Kate, K. Terashi, A. Tesi, M. Testa, C. Tetrel, D. Teytelman, J. Thaler, A. Thamm, S. Thomas, M. T. Tiirakari, V. Tikhomirov, D. Tikhonov, H. Timko, V. Tisserand, L. M. Tkachenko, J. Tkaczuk, J. Ph. Tock, B. Todd, E. Todesco, R. Tomás Garcia, D. Tommasini, G. Tonelli, F. Toral, T. Torims, R. Torre, Z. Townsend, R. Trant, D. Treille, L. Trentadue, A. Tricoli, A. Tricomi, W. Trischuk, I. S. Tropin, B. Tuchming, A. A. Tudora, B. Turbiarz, I. Turk Cakir, M. Turri, T. Tydecks, J. Usovitsch, J. Uythoven, R. Vaglio, A. Valassi, F. Valchkova, M. A. Valdivia Garcia, P. Valente, R. U. Valente, A.-M. Valente-Feliciano, G. Valentino, L. Vale Silva, J. M. Valet, R. Valizadeh, J. W. F. Valle, S. Vallecorsa, G. Vallone, M. van Leeuwen, U. H. van Rienen, L. van Riesen-Haupt, M. Varasteh, L. Vecchi, P. Vedrine, G. Velev, R. Veness, A. Ventura, W. Venturini Delsolaro, M. Verducci, C. B. Verhaaren, C. Vernieri, A. P. Verweij, O. Verwilligen, O. Viazlo, A. Vicini, G. Viehhauser, N. Vignaroli, M. Vignolo, A. Vitrano, I. Vivarelli, S. Vlachos, M. Vogel, D. M. Vogt, V. Völkl, P. Volkov, G. Volpini, J. von Ahnen, G. Vorotnikov, G. G. Voutsinas, V. Vysotsky, U. Wagner, R. Wallny, L.-T. Wang, R. Wang, K. Wang, B. F. L. Ward, T. P. Watson, N. K. Watson, Z. Wa̧s, C. Weiland, S. Weinzierl, C. P. Welsch, J. Wenninger, M. Widorski, U. A. Wiedemann, H.-U. Wienands, G. Wilkinson, P. H. Williams, A. Winter, A. Wohlfahrt, T. Wojtoń, D. Wollmann, J. Womersley, D. Woog, X. Wu, A. Wulzer, M. K. Yanehsari, G. Yang, H. J. Yang, W.-M. Yao, E. Yazgan, V. Yermolchik, Ay. Yilmaz, Al. Yilmaz, H.-D. Yoo, S. A. Yost, T. You, C. Young, T.-T. Yu, F. Yu, A. Zaborowska, S. G. Zadeh, M. Zahnd, M. Zanetti, L. Zanotto, L. Zawiejski, P. Zeiler, M. Zerlauth, S. M. Zernov, G. Zevi Dell Porta, Z. Zhang, Y. Zhang, C. Zhang, H. Zhang, Z. Zhao, Y.-M. Zhong, J. Zhou, D. Zhou, P. Zhuang, G. Zick, F. Zimmermann, J. Zinn-Justin, L. Zivkovic, A. V. Zlobin, M. Zobov, J. Zupan, J. Zurita, and The FCC Collaboration
- Subjects
Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.
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- 2019
- Full Text
- View/download PDF
98. Changes in renal function and occurrence of contrast-induced nephropathy after percutaneous coronary interventions in patients with atrial fibrillation treated with non-vitamin K oral anticoagulants or warfarin
- Author
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Rocco A. Montone, Giampaolo Niccoli, Vincenzo Tufaro, Silvia Minelli, Michele Russo, Federico Vergni, Luigi Sommariva, Francesco Pelliccia, Francesco Bedogni, and Filippo Crea
- Subjects
percutaneous coronary intervention ,warfarin ,atrial fibrillation ,non-vitamin k oral anticoagulants ,contrast-induced nephropathy ,Medicine - Published
- 2019
- Full Text
- View/download PDF
99. Correlation functions of the open XXZ chain II
- Author
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Kitanine, N., Kozlowski, K., Maillet, J. M., Niccoli, G., Slavnov, N. A., and Terras, V.
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High Energy Physics - Theory ,Condensed Matter - Statistical Mechanics ,Mathematical Physics ,Nonlinear Sciences - Exactly Solvable and Integrable Systems - Abstract
We derive compact multiple integral formulas for several physical spin correlation functions in the semi-infinite XXZ chain with a longitudinal boundary magnetic field. Our formulas follow from several effective re-summations of the multiple integral representation for the elementary blocks obtained in our previous article (I). In the free fermion point we compute the local magnetization as well as the density of energy profiles. These quantities, in addition to their bulk behavior, exhibit Friedel type oscillations induced by the boundary; their amplitudes depend on the boundary magnetic field and decay algebraically in terms of the distance to the boundary., Comment: 38 pages
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- 2008
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100. Isomorphism of critical and off-critical operator spaces in two-dimensional quantum field theory
- Author
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Delfino, G. and Niccoli, G.
- Subjects
High Energy Physics - Theory ,Condensed Matter - Statistical Mechanics ,Mathematical Physics - Abstract
For the simplest quantum field theory originating from a non-trivial fixed point of the renormalization group, the Lee-Yang model, we show that the operator space determined by the particle dynamics in the massive phase and that prescribed by conformal symmetry at criticality coincide., Comment: 16 pages, typo corrected in (2.17)
- Published
- 2007
- Full Text
- View/download PDF
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