Search

Your search keyword '"Newman, Jonathan A."' showing total 1,880 results
Start Over Author "Newman, Jonathan A."
1,880 results on '"Newman, Jonathan A."'

54. Outcomes of Participants with Diabetes in the ISCHEMIA Trials

Author

Newman, Jonathan D., Anthopolos, Rebecca, Mancini, G.B. John, Bangalore, Sripal, Reynolds, Harmony R., Kunichoff, Dennis F., Senior, Roxy, Peteiro, Jesus, Bhargava, Balram, Garg, Pallav, Escobedo, Jorge, Doerr, Rolf, Mazurek, Tomasz, Gonzalez-Juanatey, Jose, Gajos, Grzegorz, Briguori, Carlo, Cheng, Hong, Vertes, Andras, Mahajan, Sandeep, Guzman, Luis A., Keltai, Matyas, Maggioni, Aldo P., Stone, Gregg W., Berger, Jeffrey S., Rosenberg, Yves D., Boden, William E., Chaitman, Bernard R., Fleg, Jerome L., Hochman, Judith S., and Maron, David J.

Published
2021
Full Text
View/download PDF

55. Myocardial infarction accelerates breast cancer via innate immune reprogramming

Author

Koelwyn, Graeme J., Newman, Alexandra A.C., Afonso, Milessa S., van Solingen, Coen, Corr, Emma M., Brown, Emily J., Albers, Kathleen B., Yamaguchi, Naoko, Narke, Deven, Schlegel, Martin, Sharma, Monika, Shanley, Lianne C., Barrett, Tessa J., Rahman, Karishma, Mezzano, Valeria, Fisher, Edward A., Park, David S., Newman, Jonathan D., Quail, Daniela F., Nelson, Erik R., Caan, Bette J., Jones, Lee W., and Moore, Kathryn J.

Subjects
Heart attack -- Models -- Complications and side effects, Immune response -- Health aspects, Breast cancer -- Models -- Development and progression, Biological sciences, Health
Abstract

Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity.sup.1 or surgery.sup.2, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors.sup.3-5. While elevated risk and incidence of cardiovascular events in breast cancer is well established, whether such events impact cancer pathogenesis is not known. Here we show that myocardial infarction (MI) accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. In mouse models of breast cancer, MI epigenetically reprogrammed Ly6C.sup.hi monocytes in the bone marrow reservoir to an immunosuppressive phenotype that was maintained at the transcriptional level in monocytes in both the circulation and tumor. In parallel, MI increased circulating Ly6C.sup.hi monocyte levels and recruitment to tumors and depletion of these cells abrogated MI-induced tumor growth. Furthermore, patients with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis had increased risk of recurrence and cancer-specific death. These preclinical and clinical results demonstrate that MI induces alterations in systemic homeostasis, triggering cross-disease communication that accelerates breast cancer. By reprogramming innate immune cells to an immunosuppressive phenotype, myocardial infarction accelerates breast cancer progression in mice, and the clinical relevance of these findings was demonstrated in individuals with early-stage breast cancer who experienced cardiovascular events after cancer diagnosis., Author(s): Graeme J. Koelwyn [sup.1] , Alexandra A. C. Newman [sup.1] , Milessa S. Afonso [sup.1] , Coen van Solingen [sup.1] , Emma M. Corr [sup.1] , Emily J. Brown [...]

Published
2020
Full Text
View/download PDF

56. Delivery of time-varying stimuli using ChR2

Author

Tchumatchenko, Tatjana, Newman, Jonathan P., Fong, Ming-fai, and Potter, Steve M.

Subjects
Quantitative Biology - Neurons and Cognition, Quantitative Biology - Biomolecules
Abstract

To understand sensory processing in neuronal populations, it is necessary to deliver stimuli to the sensory organs of animals and record evoked population activity downstream. However, the pathways from sensory input to synaptic currents in cells that are several synapses removed from sensory organs are complex. Intrinsic noise and uncontrolled modulatory input from other brain regions can interfere with the delivery of well-defined stimuli. Here we investigate the ability of channelrhodopsins to deliver precise time-varying currents to neurons at any point along the sensory-motor pathway. To do this, we first deduce the amplitude response function of channelrhodopsin-2 (ChR2) using a three state Markov model of channel kinetics. With biophysically realistic parameters, this function supports a relatively broad signal passband and contains a resonance. We confirm the validity of our predicted amplitude response function using time-varying optical stimulation of excitatory neurons that express either wild type ChR2 or the ChR2(H134R) mutant. Together, our results indicate that ChR2-derived optogenetic tools are useful for delivering repeatable, time-varying currents to genetically-specified populations over a physiologically-relevant frequency band., Comment: 17 pages, 2 figures

Published
2013

59. An infinite family of convex Brunnian links in $R^n$

Author

Davis, Robert, Howards, Hugh, Newman, Jonathan, and Parsley, Jason

Subjects
Mathematics - Geometric Topology, 57Q45
Abstract

This paper proves that convex Brunnian links exist for every dimension $n \geq 3$ by constructing explicit examples. These examples are three-component links which are higher-dimensional generalizations of the Borromean rings., Comment: 10 pages, 4 figures

Published
2011
Full Text
View/download PDF

60. The effect of hormone therapy on mean blood pressure and visit-to-visit blood pressure variability in postmenopausal women

Author

Shimbo, Daichi, Wang, Lu, Lamonte, Michael J, Allison, Matthew, Wellenius, Gregory A, Bavry, Anthony A, Martin, Lisa W, Aragaki, Aaron, Newman, Jonathan D, Swica, Yael, Rossouw, Jacques E, Manson, JoAnn E, and Wassertheil-Smoller, Sylvia

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Cardiovascular, Clinical Research, Estrogen, Clinical Trials and Supportive Activities, Aging, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Aged, Blood Pressure, Blood Pressure Determination, Estrogen Replacement Therapy, Estrogens, Conjugated (USP), Female, Humans, Medroxyprogesterone Acetate, Middle Aged, Postmenopause, Women's Health, blood pressure, hormone therapy, hypertension, postmenopause, women, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Medical Physiology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesMean and visit-to-visit variability (VVV) of blood pressure (BP) are associated with an increased cardiovascular disease risk. We examined the effect of hormone therapy on mean and VVV of BP in postmenopausal women from the Women's Health Initiative (WHI) randomized controlled trials.MethodsBP was measured at baseline and annually in the two WHI hormone therapy trials, in which 10 739 and 16 608 postmenopausal women were randomized to conjugated equine estrogens (CEEs, 0.625 mg/day) or placebo, and CEEs and medroxyprogesterone acetate (MPA, 2.5 mg/day) or placebo, respectively.ResultsAt the first annual visit (year 1), mean SBP was 1.04 mmHg [95% confidence interval (CI) 0.58, 1.50] and 1.35 mmHg (95% CI 0.99, 1.72) higher in the CEEs and CEEs and MPA arms, respectively, compared with the corresponding placebos. These effects remained stable after year 1. CEEs also increased the VVV of SBP (ratio of VVV in CEEs vs. placebo, 1.03; P

Published
2014

62. A unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior

Author

Newman, Jonathan P, primary, Zhang, Jie, additional, Cuevas-Lopez, Aaron, additional, Miller, Nicholas J, additional, Honda, Takato, additional, van der Goes, Marie-Sophie H, additional, Leighton, Alexandra H, additional, Carvalho, Filipe, additional, Lopes, Goncalo, additional, Lakunina, Anna, additional, Siegle, Joshua H, additional, Harnett, Mark T, additional, Wilson, Matthew A, additional, and Voigts, Jakob, additional

Published
2023
Full Text
View/download PDF

63. SARS-CoV-2 infection triggers pro-atherogenic inflammatory 1 responses in human coronary vessels

Author

Eberhardt, Natalia, primary, Noval, Maria Gabriela, additional, Kaur, Ravneet, additional, Sajja, Swathy, additional, Amadori, Letizia, additional, Das, Dayasagar, additional, Cilhoroz, Burak, additional, Stewart, O Jay, additional, Fernandez, Dawn M, additional, Shamailova, Roza, additional, Guillen, Andrea Vasquez, additional, Jangra, Sonia, additional, Schotsaert, Michael, additional, Gildea, Michael, additional, Newman, Jonathan D, additional, Faries, Peter, additional, Maldonado, Thomas, additional, Rockman, Caron, additional, Rapkiewicz, Amy, additional, Stapleford, Kenneth A, additional, Narula, Navneet, additional, Moore, Kathryn J, additional, and Giannarelli, Chiara, additional

Published
2023
Full Text
View/download PDF

76. The Effect of Sensory Blind Zones on Milling Behavior in a Dynamic Self-Propelled Particle Model

Author

Newman, Jonathan P. and Sayama, Hiroki

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Emergent pattern formation in self-propelled particle (SPP) systems is extensively studied because it addresses a range of swarming phenomena which occur without leadership. Here we present a dynamic SPP model in which a sensory blind zone is introduced into each particle's zone of interaction. Using numerical simulations we discovered that the degradation of milling patterns with increasing blind zone ranges undergoes two distinct transitions, including a new, spatially nonhomogeneous transition that involves cessation of particles' motion caused by broken symmetries in their interaction fields. Our results also show the necessity of nearly complete panoramic sensory ability for milling behavior to emerge in dynamic SPP models, suggesting a possible relationship between collective behavior and sensory systems of biological organisms., Comment: 12 pages, 4 figures

Published
2007
Full Text
View/download PDF

93. Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease

Author

Nguyen, Dan D., primary, Spertus, John A., additional, Alexander, Karen P., additional, Newman, Jonathan D., additional, Dodson, John A., additional, Jones, Philip G., additional, Stevens, Susanna R., additional, O’Brien, Sean M., additional, Gamma, Reto, additional, Perna, Gian P., additional, Garg, Pallav, additional, Vitola, João V., additional, Chow, Benjamin J.W., additional, Vertes, Andras, additional, White, Harvey D., additional, Smanio, Paola E.P., additional, Senior, Roxy, additional, Held, Claes, additional, Li, Jianghao, additional, Boden, William E., additional, Mark, Daniel B., additional, Reynolds, Harmony R., additional, Bangalore, Sripal, additional, Chan, Paul S., additional, Stone, Gregg W., additional, Arnold, Suzanne V., additional, Maron, David J., additional, and Hochman, Judith S., additional

Published
2023
Full Text
View/download PDF

94. Abstract 441: Relationship Between Diabetes, Glucose Control, And Vascular Health: Findings From The American Heart Association Cardiometabolic Health Strategically Focused Research Network

Author

Garshick, Michael, primary, Barrett, Tessa A, additional, Jindal, Manila, additional, Newman, Jonathan D, additional, Fadzan, Maja, additional, Bredefeld, Cindy, additional, Levy, Natalie, additional, Akinlonu, Adedoyin, additional, Heguy, Adriana, additional, Drenkova, Kamelia, additional, Schlamp, Florencia, additional, Giannarelli, Chiara, additional, Fisher, Edward A, additional, Goldberg, Ira J, additional, and Berger, Jeffrey, additional

Published
2023
Full Text
View/download PDF

95. Abstract 116: Variation In Lipoprotein (a) Level Reduction With Potent Lipid Lowering: An Analysis Of The Cholesterol Reduction And Residual Risk In Diabetes Study

Author

Akinlonu, Adedoyin, primary, Boffa, Michael, additional, Lyu, Chen, additional, Zhong, Hua, additional, Jindal, Manila, additional, Bredefeld, Cindy, additional, Newman, Jonathan D, additional, Fisher, Edward, additional, Koschinsky, Marlys L, additional, Goldberg, Ira J, additional, and Berger, Jeffrey, additional

Published
2023
Full Text
View/download PDF

100. Abstract 13030: Causes of Cardiovascular and Non-cardiovascular Mortality in the Ischemia Trial

Author

Sidhu, Mandeep S, Alexander, Karen P, Huang, Zhen, O’Brien, Sean M, Chaitman, Bernard R, Stone, Gregg W, Newman, Jonathan D, Boden, William E, Maggioni, Aldo P, Steg, Philippe Gabriel, Ferguson, T Bruce, Demkow, Marcin, Peteiro, Jesus, Wander, Gurpreet S, de Belder, Mark A, Szwed, Hanna, Doerr, Rolf, Alexanderson, Erick, Polanczyk, Carisi, Henriksen, Peter, Conway, Dwayne, Miro, Vicente, Sharir, Tali, Rosenberg, Yves D, Bangalore, Sripal, Reynolds, Harmony R, Hochman, Judith S, and Maron, David J

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results