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498 results on '"Netea, M. G."'

76. Integration of similar to 10,000 metabolite features with genotype data and immune phenotypes reveals genetic determinants and common regulatory modules

Author

Chu, X., Jaeger, M., Bakker, O. B., Aguirre-Gamboa, R., Oosting, M., Smeekens, S. P., Withoff, S., Netea-Maier, R. T., Koenen, H. J. P. M., Joosten, I., Xavier, R. J., Franke, L., Joosten, L. A. B., Sanna, S., Kumar, V., Wijmenga, C., Netea, M. G., Li, Y., Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Molecular Neuroscience and Ageing Research (MOLAR), and Stem Cell Aging Leukemia and Lymphoma (SALL)

Published
2019

78. Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies

Author

van den Munckhof, I. C. L., Kurilshikov, A., ter Horst, R., Riksen, N. P., Joosten, L. A. B., Zhernakova, A., Fu, J., Keating, S. T., Netea, M. G., de Graaf, J., Rutten, J. H. W., Translational Immunology Groningen (TRIGR), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
obesity, INSULIN-RESISTANCE, INDUCED OBESITY, gut microbiome, digestive system, COLONIC INFLAMMATION, inflammation, INTESTINAL MICROBIOTA, Atherosclerotic cardiovascular disease, METABOLIC-DISORDERS, CAROTID ATHEROSCLEROSIS, ENDOTOXEMIA, IMMUNE-SYSTEM, TRIMETHYLAMINE-N-OXIDE, HIGH-FAT-DIET
Abstract

A hallmark of obesity is chronic low-grade inflammation, which plays a major role in the process of atherosclerotic cardiovascular disease (ACVD). Gut microbiota is one of the factors influencing systemic immune responses, and profound changes have been found in its composition and metabolic function in individuals with obesity. This systematic review assesses the association between the gut microbiota and markers of low-grade inflammation in humans. We identified 14 studies which were mostly observational and relatively small (n = 10 to 471). The way in which the microbiome is analysed differed extensively between these studies. Lower gut microbial diversity was associated with higher white blood cell counts and high sensitivity C-reactive protein (hsCRP) levels. The abundance of Bifidobacterium, Faecalibacterium, Ruminococcus and Prevotella were inversely related to different markers of low-grade inflammation such as hsCRP and interleukin (IL)-6. In addition, this review speculates on possible mechanisms through which the gut microbiota can affect low-grade inflammation and thereby ACVD. We discuss the associations between the microbiome and the inflammasome, the innate immune system, bile acids, gut permeability, the endocannabinoid system and TMAO. These data reinforce the importance of human research into the gut microbiota as potential diagnostic and therapeutic strategy to prevent ACVD.

Published
2018

87. Exome sequencing in routine diagnostics:a generic test for 254 patients with primary immunodeficiencies

Author

Arts, P. (Peer), Simons, A. (Annet), AlZahrani, M. S. (Mofareh S.), Yilmaz, E. (Elanur), AlIdrissi, E. (Eman), van Aerde, K. J. (Koen J.), Alenezi, N. (Njood), AlGhamdi, H. A. (Hamza A.), AlJubab, H. A. (Hadeel A.), Al-Hussaini, A. A. (Abdulrahman A.), AlManjomi, F. (Fahad), Alsaad, A. B. (Alaa B.), Alsaleem, B. (Badr), Andijani, A. A. (Abdulrahman A.), Asery, A. (Ali), Ballourah, W. (Walid), Bleeker-Rovers, C. P. (Chantal P.), van Deuren, M. (Marcel), van der Flier, M. (Michiel), Gerkes, E. H. (Erica H.), Gilissen, C. (Christian), Habazi, M. K. (Murad K.), Hehir-Kwa, J. Y. (Jayne Y.), Henriet, S. S. (Stefanie S.), Hoppenreijs, E. P. (Esther P.), Hortillosa, S. (Sarah), Kerkhofs, C. H. (Chantal H.), Keski-Filppula, R. (Riikka), Lelieveld, S. H. (Stefan H.), Lone, K. (Khurram), MacKenzie, M. A. (Marius A.), Mensenkamp, A. R. (Arjen R.), Moilanen, J. (Jukka), Nelen, M. (Marcel), ten Oever, J. (Jaap), Potjewijd, J. (Judith), van Paassen, P. (Pieter), Schuurs-Hoeijmakers, J. H. (Janneke H. M.), Simon, A. (Anna), Stokowy, T. (Tomasz), van de Vorst, M. (Maartje), Vreeburg, M. (Maaike), Wagner, A. (Anja), van Well, G. T. (Gijs T. J.), Zafeiropoulou, D. (Dimitra), Zonneveld-Huijssoon, E. (Evelien), Veltman, J. A. (Joris A.), van Zelst-Stams, W. A. (Wendy A. G.), Faqeih, E. A. (Eissa A.), van de Veerdonk, F. L. (Frank L.), Netea, M. G. (Mihai G.), Hoischen, A. (Alexander), Arts, P. (Peer), Simons, A. (Annet), AlZahrani, M. S. (Mofareh S.), Yilmaz, E. (Elanur), AlIdrissi, E. (Eman), van Aerde, K. J. (Koen J.), Alenezi, N. (Njood), AlGhamdi, H. A. (Hamza A.), AlJubab, H. A. (Hadeel A.), Al-Hussaini, A. A. (Abdulrahman A.), AlManjomi, F. (Fahad), Alsaad, A. B. (Alaa B.), Alsaleem, B. (Badr), Andijani, A. A. (Abdulrahman A.), Asery, A. (Ali), Ballourah, W. (Walid), Bleeker-Rovers, C. P. (Chantal P.), van Deuren, M. (Marcel), van der Flier, M. (Michiel), Gerkes, E. H. (Erica H.), Gilissen, C. (Christian), Habazi, M. K. (Murad K.), Hehir-Kwa, J. Y. (Jayne Y.), Henriet, S. S. (Stefanie S.), Hoppenreijs, E. P. (Esther P.), Hortillosa, S. (Sarah), Kerkhofs, C. H. (Chantal H.), Keski-Filppula, R. (Riikka), Lelieveld, S. H. (Stefan H.), Lone, K. (Khurram), MacKenzie, M. A. (Marius A.), Mensenkamp, A. R. (Arjen R.), Moilanen, J. (Jukka), Nelen, M. (Marcel), ten Oever, J. (Jaap), Potjewijd, J. (Judith), van Paassen, P. (Pieter), Schuurs-Hoeijmakers, J. H. (Janneke H. M.), Simon, A. (Anna), Stokowy, T. (Tomasz), van de Vorst, M. (Maartje), Vreeburg, M. (Maaike), Wagner, A. (Anja), van Well, G. T. (Gijs T. J.), Zafeiropoulou, D. (Dimitra), Zonneveld-Huijssoon, E. (Evelien), Veltman, J. A. (Joris A.), van Zelst-Stams, W. A. (Wendy A. G.), Faqeih, E. A. (Eissa A.), van de Veerdonk, F. L. (Frank L.), Netea, M. G. (Mihai G.), and Hoischen, A. (Alexander)

Abstract

Background: Diagnosis of primary immunodeficiencies (PIDs) is complex and cumbersome yet important for the clinical management of the disease. Exome sequencing may provide a genetic diagnosis in a significant number of patients in a single genetic test. Methods: In May 2013, we implemented exome sequencing in routine diagnostics for patients suffering from PIDs. This study reports the clinical utility and diagnostic yield for a heterogeneous group of 254 consecutively referred PID patients from 249 families. For the majority of patients, the clinical diagnosis was based on clinical criteria including rare and/or unusual severe bacterial, viral, or fungal infections, sometimes accompanied by autoimmune manifestations. Functional immune defects were interpreted in the context of aberrant immune cell populations, aberrant antibody levels, or combinations of these factors. Results: For 62 patients (24%), exome sequencing identified pathogenic variants in well-established PID genes. An exome-wide analysis diagnosed 10 additional patients (4%), providing diagnoses for 72 patients (28%) from 68 families altogether. The genetic diagnosis directly indicated novel treatment options for 25 patients that received a diagnosis (34%). Conclusion: Exome sequencing as a first-tier test for PIDs granted a diagnosis for 28% of patients. Importantly, molecularly defined diagnoses indicated altered therapeutic options in 34% of cases. In addition, exome sequencing harbors advantages over gene panels as a truly generic test for all genetic diseases, including in silico extension of existing gene lists and re-analysis of existing data.

Published
2019

88. Immune parameters for diagnosis and treatment monitoring in invasive mold infection

Author

Jenks, J. D., Rawlings, S. A., Garcia-Vidal, C., Koehler, P., Mercier, T., Prattes, J., Lass-Florl, C., Martin-Gomez, M. T., Buchheidt, D., Pagano, Livio, Gangneux, J. -P., van de Veerdonk, F. L., Netea, M. G., Carvalho, A., Hoenigl, M., Pagano L. (ORCID:0000-0001-8287-928X), Jenks, J. D., Rawlings, S. A., Garcia-Vidal, C., Koehler, P., Mercier, T., Prattes, J., Lass-Florl, C., Martin-Gomez, M. T., Buchheidt, D., Pagano, Livio, Gangneux, J. -P., van de Veerdonk, F. L., Netea, M. G., Carvalho, A., Hoenigl, M., and Pagano L. (ORCID:0000-0001-8287-928X)

Abstract

Infections caused by invasive molds, including Aspergillus spp., can be difficult to diagnose and remain associated with high morbidity and mortality. Thus, early diagnosis and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals with invasive mold infections. Diagnosis remains difficult due to low sensitivities of diagnostic tests including culture and other mycological tests for mold pathogens, particularly in patients on mold-active antifungal prophylaxis. As a result, antifungal treatment is rarely targeted and reliable markers for treatment monitoring and outcome prediction are missing. Thus, there is a need for improved markers to diagnose invasive mold infections, monitor response to treatment, and assist in determining when antifungal therapy should be escalated, switched, or can be stopped. This review focuses on the role of immunologic markers and specifically cytokines in diagnosis and treatment monitoring of invasive mold infections.

Published
2019

95. A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis

Author

Jaeger, M., primary, Pinelli, M., additional, Borghi, M., additional, Constantini, C., additional, Dindo, M., additional, van Emst, L., additional, Puccetti, M., additional, Pariano, M., additional, Ricaño-Ponce, I., additional, Büll, C., additional, Gresnigt, M. S., additional, Wang, X., additional, Gutierrez Achury, J., additional, Jacobs, C. W. M., additional, Xu, N., additional, Oosting, M., additional, Arts, P., additional, Joosten, L. A. B., additional, van de Veerdonk, F. L., additional, Veltman, J. A., additional, ten Oever, J., additional, Kullberg, B. J., additional, Feng, M., additional, Adema, G. J., additional, Wijmenga, C., additional, Kumar, V., additional, Sobel, J., additional, Gilissen, C., additional, Romani, L., additional, and Netea, M. G., additional

Published
2019
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96. Human Bacille Calmette-Guérin Vaccination Elicits Trained Immunity Via the Hematopoietic Progenitor Compartment

Author

Cirovic, B., primary, de Bree, L. C. J., additional, Groh, L., additional, Blok, B. A., additional, Chan, J., additional, Velden, W.J.F.M. van der, additional, Bremmers, M. E. J., additional, van Crevel, Reinout, additional, Händler, K., additional, Picelli, S., additional, Schulte-Schrepping, J., additional, Klee, K., additional, Oosting, M., additional, Li, Y., additional, Benn, C. S., additional, Schultze, Joachim L., additional, Joosten, L. A. B., additional, Curtis, N., additional, Netea, M. G., additional, and Schlitzer, Andreas, additional

Published
2019
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