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53. OC.10.4: Survival of Non-Familial Small Bowel Carcinomas Depends on the Underlying Intestinal Immune-Mediated Disorder

Author

Di Sabatino, A., primary, Vanoli, A., additional, Furlan, D., additional, Giuffrida, P., additional, Klersy, C., additional, Grillo, F., additional, Fiocca, R., additional, Mescoli, C., additional, Rugge, M., additional, Nesi, G., additional, Fociani, P., additional, Sampietro, G.M., additional, Ardizzone, S., additional, Luinetti, O., additional, Calabrò, A., additional, Tonelli, F., additional, Volta, U., additional, Santini, D., additional, Elli, L., additional, Ferrero, S., additional, Latella, G., additional, Ciardi, A., additional, Solina, G., additional, Rizzo, A., additional, Ciacci, C., additional, D’Armiento, F.P., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Reggiani Bonetti, L., additional, Biancone, L., additional, Monteleone, G., additional, Orlandi, A., additional, Santeusanio, G., additional, Macciomei, M.C., additional, D’Incà, R., additional, Perfetti, V., additional, Sandri, G., additional, Silano, M., additional, Giannone, A.G., additional, Papi, C., additional, Coppola, L., additional, Usai, P., additional, Maccioni, A., additional, Astegiano, M., additional, Migliora, P., additional, Manca, R., additional, Martino, M., additional, Trapani, D., additional, Cerutti, R., additional, Alberizzi, P., additional, Riboni, R., additional, Sessa, F., additional, Paulli, M., additional, Solcia, E., additional, and Corazza, G.R., additional

Published
2017
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54. Analisi delle varianti rare del carcinoma a cellule uroteliali della vescica nei Pazienti sottoposti a cistectomia radicale: impatto sulla prognosi

Author

Cai, T, Tiscione, D, Pomara, G, Verze, P, Racioppi, M, Nesi, G, Brausi, M, Gacci, M, Gontero, P, Francesca, F, Campodonico, F, Simonato, A, Di Stasi, S, Colombo, R, Carmignani, C, Malossini, G, Maffezzini, M, Altieri, V, Carini, M, Terrone, C, Selli, C, Bassi, P, Mirone, V, Bartoletti, R., SERRETTA, Vincenzo, Cai, T, Tiscione, D, Pomara, G, Verze, P, Racioppi, M, Nesi, G, Brausi, M, Gacci, M, Gontero, P, Francesca, F, Campodonico, F, Simonato, A, Di Stasi, S, Colombo, R, Serretta, V, Carmignani, C, Malossini, G, Maffezzini, M, Altieri, V, Carini, M, Terrone, C, Selli, C, Bassi, P, Mirone, V, and Bartoletti, R

Subjects
Tumore vescicale, cistectomia, istologia, Settore MED/24 - Urologia
Published
2013

56. Intraductal carcinoma of prostate reporting practice: a survey of expert European uropathologists

Author

Varma, M., Egevad, L., Algaba, F., Berney, D., Bubendorf, L., Camparo, P., Comperat, E., Erbersdobler, A., Griffiths, D., Grobholz, R., Haitel, A., Hulsbergen-van de Kaa, C.A., Langner, C., Loftus, B., Lopez-Beltran, A., Mayer, N., Nesi, G., Oliveira, P., Oxley, J., Rioux-Leclercq, N., Seitz, G., Shanks, J., Kristiansen, G., Varma, M., Egevad, L., Algaba, F., Berney, D., Bubendorf, L., Camparo, P., Comperat, E., Erbersdobler, A., Griffiths, D., Grobholz, R., Haitel, A., Hulsbergen-van de Kaa, C.A., Langner, C., Loftus, B., Lopez-Beltran, A., Mayer, N., Nesi, G., Oliveira, P., Oxley, J., Rioux-Leclercq, N., Seitz, G., Shanks, J., and Kristiansen, G.

Abstract

Item does not contain fulltext, BACKGROUND: It is unclear whether the reported variation in the diagnosis of intraductal carcinoma of the prostate (IDC-P) is due to variable interpretation of borderline morphology, use of different diagnostic criteria or both. AIMS: We sought to determine the degree of variation in the diagnostic criteria and reporting rules for IDC-P in prostate biopsies employed by expert uropathologists. METHODS: A questionnaire survey was circulated to 23 expert uropathologists from 11 European countries. RESULTS: Criteria used for diagnosis of IDC-P included solid intraductal growth (100%), dense cribriform (96%), loose cribriform/micropapillary with nuclear size >6x normal (83%) or comedonecrosis (74%) and dilated ducts >2x normal (39%). 'Nuclear size' was interpreted as nuclear area by 74% and nuclear diameter by 21%. Pure IDC-P in needle biopsies was reported by 100% and Gleason graded by 30%. All would perform immunohistochemistry in such cases to rule out invasive cancer. An IDC-P component associated with invasive cancer would be included in the determination of tumour extent and number of cores involved by 74% and 83%, respectively. 52% would include IDC-P component when grading invasive cancer. 48% would perform immunohistochemistry in solid or cribriform nests with comedonecrosis to exclude IDC-P (17% routinely, 30% if the focus appeared to have basal cells on H&E). 48% graded such foci as Gleason pattern 5 even if immunohistochemistry demonstrated the presence of basal cells. CONCLUSIONS: There is a need for more clarity in the definition of some of the diagnostic criteria for IDC-P as well as for greater standardisation of IDC-P reporting.

Published
2016

60. FATTORI PREDITTIVI DI PATOLOGIA EXTRACAPSULARE IN PAZIENTI AFFETTI DA ETP PROSTATA IN STADIO CLINICO INFERIORE O UGUALE A CT2, CON GLEASON SCORE BIOPTICO INFERIORE O UGUALE A 3+3 E PSA PREOPERATORIO INFERIORE O UGUALE A 10

Author

Gacci M, Lapini A, SALONIA, ANDREA, Mearini L, Nesi G, Palli D, MONTORSI, FRANCESCO, Rigatti P, Porena M, Carini M., BRIGANTI , ALBERTO, Gacci, M, Lapini, A, Salonia, Andrea, Mearini, L, Nesi, G, Palli, D, Briganti, Alberto, Montorsi, Francesco, Rigatti, P, Porena, M, and Carini, M.

Published
2006

63. OC.11.2 CROHN'S DISEASE-ASSOCIATED SMALL BOWEL CARCINOMAS SHOW DISTINCTIVE HISTOLOGY AND PHENOTYPE IN COMPARISON TO SPORADIC CASES: AN ITALIAN MULTICENTRE STUDY

Author

Vanoli, A., primary, Grillo, F., additional, Mescoli, C., additional, Nesi, G., additional, Giuffrida, P., additional, Papi, C., additional, Luinetti, O., additional, Sampietro, G., additional, Latella, G., additional, Fociani, P., additional, Tonelli, F., additional, Cannizzaro, R., additional, Coppola, L., additional, D'Incà, R., additional, Monteleone, G., additional, Biancone, L., additional, Solina, G., additional, Villanacci, V., additional, Martino, M., additional, Orlandi, A., additional, Rizzo, A., additional, Salemme, M., additional, Astegiano, M., additional, Migliora, P., additional, Rugge, M., additional, Fiocca, R., additional, Corazza, G.R., additional, Solcia, E., additional, and Di Sabatino, A., additional

Published
2016
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66. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

Author

Papathomas, T.G., Oudijk, L., Persu, A., Gill, A.J., Nederveen, F. van, Tischler, A.S., Tissier, F., Volante, M, Matias-Guiu, X., Smid, M., Favier, J., Rapizzi, E., Libe, R., Curras-Freixes, M., Aydin, S., Huynh, T., Lichtenauer, U., Berkel, A van, Canu, L., Domingues, R., Clifton-Bligh, R.J., Bialas, M., Vikkula, M., Baretton, G., Papotti, M., Nesi, G., Badoual, C., Pacak, K., Eisenhofer, G., Timmers, H.J.L.M., Beuschlein, F., Bertherat, J., Mannelli, M., Robledo, M., Gimenez-Roqueplo, A.P., Dinjens, W.N., Korpershoek, E., Krijger, R.R. de, Papathomas, T.G., Oudijk, L., Persu, A., Gill, A.J., Nederveen, F. van, Tischler, A.S., Tissier, F., Volante, M, Matias-Guiu, X., Smid, M., Favier, J., Rapizzi, E., Libe, R., Curras-Freixes, M., Aydin, S., Huynh, T., Lichtenauer, U., Berkel, A van, Canu, L., Domingues, R., Clifton-Bligh, R.J., Bialas, M., Vikkula, M., Baretton, G., Papotti, M., Nesi, G., Badoual, C., Pacak, K., Eisenhofer, G., Timmers, H.J.L.M., Beuschlein, F., Bertherat, J., Mannelli, M., Robledo, M., Gimenez-Roqueplo, A.P., Dinjens, W.N., Korpershoek, E., and Krijger, R.R. de

Abstract

Item does not contain fulltext, Despite the established role of SDHB/SDHA immunohistochemistry as a valuable tool to identify patients at risk for familial succinate dehydrogenase-related pheochromocytoma/paraganglioma syndromes, the reproducibility of the assessment methods has not as yet been determined. The aim of this study was to investigate interobserver variability among seven expert endocrine pathologists using a web-based virtual microscopy approach in a large multicenter pheochromocytoma/paraganglioma cohort (n=351): (1) 73 SDH mutated, (2) 105 non-SDH mutated, (3) 128 samples without identified SDH-x mutations, and (4) 45 with incomplete SDH molecular genetic analysis. Substantial agreement among all the reviewers was observed either with a two-tiered classification (SDHB kappa=0.7338; SDHA kappa=0.6707) or a three-tiered classification approach (SDHB kappa=0.6543; SDHA kappa=0.7516). Consensus was achieved in 315 cases (89.74%) for SDHB immunohistochemistry and in 348 cases (99.15%) for SDHA immunohistochemistry. Among the concordant cases, 62 of 69 (~90%) SDHB-/C-/D-/AF2-mutated cases displayed SDHB immunonegativity and SDHA immunopositivity, 3 of 4 (75%) with SDHA mutations showed loss of SDHA/SDHB protein expression, whereas 98 of 105 (93%) non-SDH-x-mutated counterparts demonstrated retention of SDHA/SDHB protein expression. Two SDHD-mutated extra-adrenal paragangliomas were scored as SDHB immunopositive, whereas 9 of 128 (7%) tumors without identified SDH-x mutations, 6 of 37 (~16%) VHL-mutated, as well as 1 of 21 (~5%) NF1-mutated tumors were evaluated as SDHB immunonegative. Although 14 out of those 16 SDHB-immunonegative cases were nonmetastatic, an overall significant correlation between SDHB immunonegativity and malignancy was observed (P=0.00019). We conclude that SDHB/SDHA immunohistochemistry is a reliable tool to identify patients with SDH-x mutations with an additional value in the assessment of genetic variants of unknown significance. If SDH molecular genetic analysis

Published
2015

69. Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

Author

Sestito, S., Nesi, G., Daniele, S., Martelli, A., Digiacomo, M., Borghini, A., Pietra, D., Calderone, V., Lapucci, A., Falasca, Marco, Parrella, P., Notarangelo, A., Breschi, M., Macchia, M., Martini, C., Rapposelli, S., Sestito, S., Nesi, G., Daniele, S., Martelli, A., Digiacomo, M., Borghini, A., Pietra, D., Calderone, V., Lapucci, A., Falasca, Marco, Parrella, P., Notarangelo, A., Breschi, M., Macchia, M., Martini, C., and Rapposelli, S.

Abstract

© 2015 Elsevier Masson SAS. Aggressive behavior and diffuse infiltrative growth are the main features of Glioblastoma multiforme (GBM), together with the high degree of resistance and recurrence. Evidence indicate that GBM-derived stem cells (GSCs), endowed with unlimited proliferative potential, play a critical role in tumor development and maintenance. Among the many signaling pathways involved in maintaining GSC stemness, tumorigenic potential, and anti-apoptotic properties, the PDK1/Akt pathway is a challenging target to develop new potential agents able to affect GBM resistance to chemotherapy. In an effort to find new PDK1/Akt inhibitors, we rationally designed and synthesized a small family of 2-oxindole derivatives. Among them, compound 3 inhibited PDK1 kinase and downstream effectors such as CHK1, GS3Ka and GS3Kß, which contribute to GCS survival. Compound 3 appeared to be a good tool for studying the role of the PDK1/Akt pathway in GCS self-renewal and tumorigenicity, and might represent the starting point for the development of more potent and focused multi-target therapies for GBM.

Published
2015

72. Sclerosing variant of PEComa: report of a case and review of the literature

Author

Santi R, ALESSANDRO FRANCHI, Villari D, Paglierani M, Pepi M, Danielli D, Nicita G, and Nesi G

Subjects
Sclerosis, Perivascular Epithelioid Cell Neoplasms, Sclerosing PEComa, 6 - Ciencias aplicadas::61 - Medicina::611 - Anatomía [CDU], Aged, Female, Humans, Retroperitoneal Neoplasms, Retro-peritoneal tumours
Abstract

Tumours of perivascular epithelioid cells (PEComas) are a heterogeneous group of uncommon mesenchymal neoplasms which exhibit a peculiar immunohistochemical co-expression of muscle and melanocytic markers. PEComas occur at various visceral and soft tissue sites, generally with a benign clinical course. Nevertheless, there has been evidence of cases having an unfavourable outcome, thus prompting investigation of pathological criteria for malignancy. A sclerosing variant of PEComa, more frequently encountered in the retroperitoneum of middle-aged women, has been reported. Prognosis has generally been regarded as favourable and complete surgical excision appears to be adequate treatment. To the best of our knowledge, only two cases of sclerosing PEComa displayed high-grade malignant morphology and were associated with adverse outcome. An additional case of retroperitoneal sclerosing PEComa with a two-year follow-up and indolent behaviour is herein described. Light and electron microscopy were performed, along with immunohistochemical analysis. Further studies are needed to clarify the histogenesis and to predict the biological behaviour of this uncommon entity.

Published
2012

78. Re: Predicting biochemical recurrence-free survival for patients with positive pelvic lymph nodes at radical prostatectomy: C. Von Bodman, G. Godoy, D. C. Chade, A. Cronin, L. J. Tafe, S. W. Fine, V. Laudone, P. T. Scardino and J. A. Eastham J Urol 2010; 184: 143-148

Author

Cai, T, Nesi, G, Malossini, G, and Bartoletti, Riccardo

Subjects
Male, Prostatectomy, Predictive Value of Tests, Lymphatic Metastasis, Disease-Free Survival, Humans, Prostate-Specific Antigen, Prostatic Neoplasms
Published
2011

82. Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens

Author

Cai, T, Tiscione, D, Verze, P, Pomara, G, Racioppi, Marco, Nesi, G, Barbareschi, M, Brausi, M, Gacci, M, Luciani, Lg, Liguori, G, Gontero, P, Campodonico, F, Simonato, A, Boddi, V, Di Stasi, Sm, Colombo, R, Serretta, V, Carmignani, G, Malossini, G, Altieri, V, Carini, M, Terrone, C, Bassi, Pierfrancesco, Montorsi, F, Ficarra, V, Selli, C, Mirone, V, Bartoletti, R., Racioppi, Marco (ORCID:0000-0001-9129-8479), Bassi, Pierfrancesco (ORCID:0000-0002-4313-8427), Cai, T, Tiscione, D, Verze, P, Pomara, G, Racioppi, Marco, Nesi, G, Barbareschi, M, Brausi, M, Gacci, M, Luciani, Lg, Liguori, G, Gontero, P, Campodonico, F, Simonato, A, Boddi, V, Di Stasi, Sm, Colombo, R, Serretta, V, Carmignani, G, Malossini, G, Altieri, V, Carini, M, Terrone, C, Bassi, Pierfrancesco, Montorsi, F, Ficarra, V, Selli, C, Mirone, V, Bartoletti, R., Racioppi, Marco (ORCID:0000-0001-9129-8479), and Bassi, Pierfrancesco (ORCID:0000-0002-4313-8427)

Abstract

To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.

Published
2014

88. CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study

Author

Palli, D. Masala, G. Del Giudice, G. Plebani, M. Basso, D. Berti, D. Numans, M.E. Ceroti, M. Peeters, P.H.M. Bas Bueno De Mesquita, H. Buchner, F.L. Clavel-Chapelon, F. Boutron-Ruault, M.-C. Krogh, V. Saieva, C. Vineis, P. Panico, S. Tumino, R. Nyrén, O. Simán, H. Berglund, G. Hallmans, G. Sanchez, M.-J. Larrãnaga, N. Barricarte, A. Navarro, C. Quiros, J.R. Key, T. Allen, N. Bingham, S. Khaw, K.T. Boeing, H. Weikert, C. Linseisen, J. Nagel, G. Overvad, K. Thomsen, R.W. Tjonneland, A. Olsen, A. Trichoupoulou, A. Trichopoulos, D. Arvaniti, A. Pera, G. Kaaks, R. Jenab, M. Ferrari, P. Nesi, G. Carneiro, F. Riboli, E. Gonzalez, C.A.

Abstract

Helicobacter pylori (H. pylori), atrophic gastritis, dietary and lifestyle factors have been associated with gastric cancer (GC). These factors have been evaluated in a large case-control study nested in the European Prospective Investigation into Cancer and Nutrition carried out in 9 countries, including the Mediterranean area. Participants, enrolled in 1992-1998, provided life-style and dietary information and a blood sample (360,000; mean follow-up: 6.1 years). For 233 GC cases diagnosed after enrolment and their 910 controls individually-matched by center, gender, age and blood donation date H. pylori antibodies (antilysate and antiCagA) and plasma Pepsinogen A (PGA) were measured by ELISA methods. Severe chronic atrophic gastritis (SCAG) was defined as PGA circulating levels

Published
2007

91. SDH mutations in patients affected by paraganglioma syndromes

Author

Mannelli, M, Simi, L, Ercolino, T, Gagliano, Ms, Becherini, L, Vinci, S, Sestini, R, Gensini, F, Pinzani, P, Mascalchi, M, Guerrini, L, Pratesi, C, Nesi, G, Torti, F, Cipollini, F, Bernini, Giampaolo, and Genuardi, M.

Published
2006

95. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Author

González, C.A. Jakszyn, P. Pera, G. Agudo, A. Bingham, S. Palli, D. Ferrari, P. Boeing, H. del Giudice, G. Plebani, M. Carneiro, F. Nesi, G. Berrino, F. Sacerdote, C. Tumino, R. Panico, S. Berglund, G. Simán, H. Nyrén, O. Hallmans, G. Martinez, C. Dorronsoro, M. Barricarte, A. Navarro, C. Quirós, J.R. Allen, N. Key, T.J. Day, N.E. Linseisen, J. Nagel, G. Bergmann, M.M. Overvad, K. Jensen, M.K. Tjonneland, A. Olsen, A. Bueno-de-Mesquita, H.B. Ocke, M. Peeters, P.H.M. Numans, M.E. Clavel-Chapelon, F. Boutron-Ruault, M.-C. Trichopoulou, A. Psaltopoulou, T. Roukos, D. Lund, E. Hemon, B. Kaaks, R. Norat, T. Riboli, E.

Abstract

Background: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. Methods: A total of 521 457 men and women aged 35=70 years in 1 0 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric noncardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. Results: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric noncardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric noncardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. Conclusion: Total, red, and processed meat intakes were associated with an increased risk of gastric noncardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer. © 2006 Oxford University Press.

Published
2006

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