51. Why Brain Criticality Is Clinically Relevant: A Scoping Review
- Author
-
Vincent Zimmern
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Cognitive Neuroscience ,brain ,Models, Neurological ,Neuroscience (miscellaneous) ,Review ,anesthesia ,Sleep medicine ,lcsh:RC321-571 ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Application areas ,medicine ,Humans ,Relevance (information retrieval) ,criticality ,sleep ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Cognitive science ,neurodevelopment ,Information processing ,neurodegeneration ,Cognition ,Models, Theoretical ,Temporal correlation ,Neonatal hypoxia ,Sensory Systems ,030104 developmental biology ,Criticality ,epilepsy ,Psychology ,long-range temporal correlation ,Neuroscience ,030217 neurology & neurosurgery - Abstract
The past 25 years have seen a strong increase in the number of publications related to criticality in different areas of neuroscience. The potential of criticality to explain various brain properties, including optimal information processing, has made it an increasingly exciting area of investigation for neuroscientists. Recent reviews on this topic, sometimes termed brain criticality, make brief mention of clinical applications of these findings to several neurological disorders such as epilepsy, neurodegenerative disease, and neonatal hypoxia. Other clinicallyrelevant domains – including anesthesia, sleep medicine, developmental-behavioral pediatrics, and psychiatry – are seldom discussed in review papers of brain criticality. Thorough assessments of these application areas and their relevance for clinicians have also yet to be published. In this scoping review, studies of brain criticality involving human data of all ages are evaluated for their current and future clinical relevance. To make the results of these studies understandable to a more clinical audience, a review of the key concepts behind criticality (e.g., phase transitions, long-range temporal correlation, self-organized criticality, power laws, branching processes) precedes the discussion of human clinical studies. Open questions and forthcoming areas of investigation are also considered.
- Published
- 2020