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A new generation carbapenem, ertapenem has an important advantage as it can be administered once a day. Among carbapenems imipenem is known to have neurotoxic side effects and reduces the seizure threshold in the kidney diseases’ patient population. Rare cases of ertapenem neurotoxicity have been reported. We present a 53-year-old kidney transplant recipient with generalized convulsions who had renal dysfunction and was under ertapenem treatment due to urinary tract infection. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi is the property of Istanbul Tip Fakultesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Hepatitis Infection with hepatitis A virüs virus (HAV) infection is a common public health problem in our country and in the world. The prevalence of disease Prevalence of this disease, that which can be the a serious reason for morbidity and mortality reason, is closely related with socio-economic conditions and environmental factors. In this study, we aimed to investigate the seroprevalence of hepatitis A in pediatric age groups in Bingöl province. Methods: In this study, we retrospectively evaluated the results of 4211 pediatric patients who requested HAV IgG and HAV IgM tests for various reasons and were admitted to our hospital between January 2010 and June 2016. Chi-square test was used to determine the statistical differences between categorical variables. Results: The mean age of the patient ages in the this study was 8.9±5.8 years (min-max: 0-18 years). Of all patients, 44.5% of the patients were male and 55.5% were female. The total HAV Ig G seropositivity rate was found to be 58%. When The anti-HAV Ig G seropositivity rates were analyzed according to age groups, they were found to be 54.2% in patients aged below 2 years, 38.2% in 2-6 years, 49.6% in 7-10 years, and 78.2% in 11-18 years. The total HAV Ig M seropositivity rate was found to be 11.6%. When anti-HAV Ig M seropositivity rates were analyzed according to months, it was found to be higher in December (17.9%) and November (17.1%) and the least in May (4.6%) and June (5.2%). Conclusion: It has been determined that the frequency of acute hepatitis A cases increases in December and November and that the seropositivity of hepatitis A Ig G increases with age after 2 years. In cases under below 2 years of age, the seropositivity of HAV Ig G is high and the seropositivity that of HAV Ig M is low, which is thought to be related to with vaccination and maternal antibodies. [ABSTRACT FROM AUTHOR]

Introduction: Vancomycin-resistance in enterococci (VRE) poses a major threat in hospitals. It is well known that patients in the neonatal intensive care unit (NICU) is especially at risk of nosocomial VRE acquisition. In this study, it was aimed to present the VRE outbreak analysis identified in NICU. Materials and Methods: Patients with VRE colonization and infection were included in the study between 17.10.2016-30.03.2017 in NICU. Results: There are a total of 30 beds in the NICU, including five beds in the level 1 ICU, eight beds in the level 2 ICU and 17 beds in the level 3 ICU. Newborns in the NICU are hospitalised in the same ICU (room) in a mixed form. Enterococci were detected in blood culture samples of four patients in the NICU. Three of these cases were VRE and the other was VSE (vancomycin-sensitive enterococci). The most important problem identified in the NICU was the inability to use the interior architecture effectively. In addition, inadequate nurse both in number and level of education and lack of night observations were identified as other problems. Conclusion: As a result, the outbreak in NICU was controlled thanks to educated nurse support, frequent visits and change in interior architecture. [ABSTRACT FROM AUTHOR]

Background and Design: Ischemia-modified albumin (IMA) is a biomarker, which is an indicator of ischemia and oxidative stress, and measured by the albumin cobalt binding test. Androgenetic alopecia (AGA) is the most important cause of hair loss in males. Hair loss that is affected by androgenic hormones, age, and ethnic, family and environmental factors, may lead to psychological, social and physical problems in some individuals. The aim of the present study was to investigate the factors affecting AGA, and the correlation between AGA and IMA. Materials and Methods: Fifty male patients with AGA aged 18-35 years and 30 males of similar age without AGA were included in the study. Patients with AGA stage 3 or higher were included in the study group. Blood samples were collected after a 12-hour fasting period. Blood glucose, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride, insulin, testosterone, dehydroepiandrosterone-sulfate (DHEA-S), and albumin levels were analyzed using an autoanalyzer. IMA values were evaluated using a MINDRAY BS 2000 autoanalyzer. Results: A total of 80 individuals were included in the study. There was no significant difference in mean age (p=0.179), body mass index (p=0.847), DHEA-S (p=0.247), testosterone (p=0.874), lipid profile [triglyceride (p=0.086), total cholesterol (p=0.492), HDL (p=0.993), LDL (p=0.544)], insulin resistance (p=0.399) and IMA (p=0.976) between study group and control group. Additionally, a family history of alopecia was found to be significantly higher in the study group (p=0.000). Moreover, there was a positive correlation between AGA grade and insulin resistance (r=0.296; p=0.037). Conclusion: AGA, which leads to many cosmetic and psychosocial problems, was more frequent in individuals with a family history of alopecia; also, there was a positive correlation between AGA stage and insulin resistance. On the other hand, there was no significant correlation between AGA and IMA. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Actinomycosis is a chronic progressive bacterial infection caused by anaerobic Actinomyces species. Major clinical forms are cervicofacial, thoracic and abdominal actinomycosis. With history, clinical and radiological findings actinomyotic sulfur granules seen in patient samples is important for diagnosis. Since it is a rare disease, to take attention, we aimed to evaluate actinomycosis cases followed in our clinic. Materials and Methods: Actinomycosis cases followed between the years 2000-2016 were evaluated retrospectively. The demographic characteristics of patients, clinical actinomycosis type, involvement region, concomitant diseases, data related to the prognosis of the disease and the duration of antibiotic use were recorded. Results: The mean age was 56.9 ± 10.2 years, and all of eight (61.5%) were male and total 13 patients were evaluated. Cervicofacial (69.2%), thoracic (15.4%) and abdominal (15.4%) type actinomycosis were recorded in order of frequency. All of the cases were diagnosed clinically and pathologically. Except two patients all of them were treated with penicillin. The total mean treatment duration was six months, for the first month parenterally. One patient died because of primary disease, treatment was successful in 12 patients. Conclusion: Actinomycosis is an infectious disease, difficult to diagnose due to the chronic slowly progressive process can involve a variety of systems. Successful results are avaliable with early diagnosis and appropriate antibiotic therapy. [ABSTRACT FROM AUTHOR]

Necrotizing fasciitis is a serious soft tissue infection with rapidly spreading inflammation, thrombosis and necrosis affecting the skin, subcutaneous tissue and fasciae. The disease should be diagnosed early and appropriate antibiotherapy and surgical debridement should be applied. Delay in diagnosis or treatment significantly increases the morbidity and mortality of the disease. The aim of this report is to present a case with mortal necrotizing fasciitis in the light of the literature. [ABSTRACT FROM AUTHOR]

Copyright of Mediterranean Journal of Infection, Microbes & Antimicrobials is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mediterranean Journal of Infection, Microbes & Antimicrobials is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mediterranean Journal of Infection, Microbes & Antimicrobials is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Giriş: Sifiliz, etkeni Treponema pallidum isimli bir spiroket olan ve genellikle cinsel yolla bulaşan multisistemik bir hastalıktır. Son yıllarda HIV ile enfekte bireylerde sifiliz sıklığı artmaktadır. Sifiliz ilk olarak Sör William Osler tarafından “büyük taklitçi” olarak tanımlanmıştır. Hastalığın seyri boyunca, vücuttaki tüm organlar tutulabilir. Hastalık, semptomatik ya da asemptomatik olarak seyredebilir. Ağrısız tek bir genital ülser, deri döküntüsü, mukokutanöz lezyonlar ve lenfadenopati gibi birçok patolojiye neden olur. Sekonder sifilizde en karakteristik bulgu döküntü olmakla birlikte sıklıkla döküntü karakteri makülo papüler tarzdadır. Nadir veziküler formda lezyonların izlendiği olgu sunumları mevcuttur. Bu olgumuzda HIV ile enfekte bir bireyde gelişen nadir görülen veziküler formda lezyonların izlendiği sekonder sifiliz olgusuna yer verilmiştir. Olgu: Otuz yedi yaşında, beş yıldır HIV ile enfekte olan erkek hasta, bir haftadır var olan yüzde başlayıp gövde ve tüm ekstremitelere yayılan, kaşıntısız deri lezyonları ve ateş öyküsü ile başvurdu. Hastanın TDF/FTC + RAL tedavisi altında viral baskılanması sağlanmış olup, ilaç kullanımı düzenli idi. Öyküde bilinen yeni şüpheli cinsel teması, ek ilaç kullanımı mevcut değildi. Genital şankr öyküsü yoktu. Yapılan fizik muayenesinde yüzde, gövdede, tüm ekstremiteler ile avuç içi ve ayak tabanında makülopapüler karakterde lezyonlar ile yüz ve gövdede dağınık yerleşimli veziküler karakterde lezyonlar ile bilateral inguinal bölgede multiple milimetrik lenfadenopati izlendi. Eşlik eden sol alt ekstremite ön yüzde lezyonlar etrafında eritem ve ısı artışı varlığı mevcuttu. Hastaya varisella enfeksiyonu, sifiliz, ilaç erüpsiyonu, sweet sendromu ön tanıları ve eşlik eden yumuşak doku enfeksiyonu nedeniyle yatış verildi. Ampisilin-sulbaktam 4x1 g/gün iv tedavisi başlandı. Gönderilen tetkiklerinde VDRL ve TPHA pozitif izlendi (Tablo 1). Hastaya tek doz benzatin penisilin G 2,4 milyon U/im uygulandı. Takiplerinin 1. haftasında mevcut lezyonlarda yüzden başlayarak gerileme izlendi. Sol alt ekstremitede eritem, hassasiyet ve ısı artışı kayboldu. Sonuç: Sifilizin güncelliğini koruyan bir enfeksiyon hastalığı olması ile birlikte, bu hastalar birçok farklı klinik seyirlerle başvurabileceğinden hekimler dikkatli olmalıdır. HIV ile enfekte bireylerde sifiliz sıklığı diğer popülasyonlara göre daha yüksek seyretmektedir. HIV enfeksiyonu (özellikle ileri evrelerde), sifiliz enfeksiyonunun tanısını, doğal seyrini veya yönetimini bazen değiştirebilse de sifilizin klinik bulguları, tanı ve tedavisinin prensipleri, genellikle HIV ile enfekte olmayan kişilerdeki ile aynıdır. [ABSTRACT FROM AUTHOR]

Objective: Herpes Zoster is an exanthematous disease composed of vesicles and bullae on an erythematous ground in a skin region compatible with the dermatome or dermatomes of one or more sensorial nerves. The aim of this study was to evaluate the opinions of patients with Herpes Zoster on their disease such as cause, triggering factors and outcome and to investigate the elements that might affect these opinions. Material and Methods: Sixty patients older than 18 years presenting with pain and rash, who were clinically diagnosed to have Herpes Zoster were included in the study. A survey form including multiple choice questions that were obtained as a result of a literature search by the investigators was used to be applied in patients with Herpes Zoster. Results: Among the participants, 33 (55%) were males and 27 (45%) were females. Level of education of the cases was low in 81.7% (illiterate, elementary, middle and high school) and high in 18.3% (university) . The most frequently selected cause for triggering and exacerbating causes of the disease was stress. About the answers on the outcome of the disease, 25% of the patients thought that they would completely be healed, 21.7% though that they would be healed but the disease would recur, 18.3% thought that they wouldn't get well, and 35% responded as they had no idea on this subject. Conclusion: The knowledge of the patients on Herpes Zoster disease was found to be inadequate. [ABSTRACT FROM AUTHOR]

Community acquired pneumonia is a common and serious illness worldwide. The most common causative agents are Streptococcus pneumoniae and Mycoplasma pneumoniae. Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) emerges as agent of pneumonia in healthy people without health care risk factor. Cavitary pneumonia which is caused by CA-MRSA, has high mortality and morbidity. Therefore, early diagnosis and treatment are crucial. In this paper, we aimed to present a case of community-acquired pneumonia related cavitary lesion due to MRSA. [ABSTRACT FROM AUTHOR]

Giriş: Salmonella enfeksiyonları, mortalite ve morbidite açısından global bir sorun olmaya günümüzde de devam etmektedir. Endojen endoftalmi (EE), Salmonella enfeksiyonlarının seyri esnasında nadir görülen ancak agresif seyredebilen, korkutucu bir komplikasyondur. Salmonella’nın osteoartiküler enfeksiyonlarından septik artrit tanısı ile takip edilen, immünosüpresif bir hastada gelişen endoftalmi komplikasyonundan bahsedilmiştir. Olgu: Yirmi üç yaşındaki erkek hastanın son bir haftadır sol dizde ağrı ve şişlik şikayeti mevcuttu. Fizik muayenesinde patolojik bulgu olarak sol dizde ısı artışı ve kızarıklık saptandı. Ateş 36,5 °C, kan basıncı 130/70 mmHg ve nabız 84/dakika ölçüldü. Hastanın özgeçmişinde membaroproliferatif glomerülonefrit tanısıyla siklosporin ve yüksek doz steroid kullanım öyküsü mevcuttu. Periferik kanda lökosit sayısı 10.850/mm³, eritrosit sedimentasyon hızı 113 mm/saat, CRP 157 mg/dl idi. Ortopedi ve travmatoloji kliniği tarafından septik artrit ön tanısı ile hastaya eklem ponksiyonu yapıldı. Eklem sıvısında mm³’te, %95’i PNL olan 37 100 lökosit tespit edildi. Kültür için eklem sıvısından örnek gönderildi ve ampirik olarak septik artrite yönelik seftriakson 2x1 gr/gün tedavisi başlandı. Sinovial sıvı kültüründe Salmonella spp. üremesi oldu. Seftriakson tedavisinin yedinci gününde hastada sepsis bulguları gelişti. Kan, idrar ve gaita kültürü alındı, hastane kaynaklı bir sepsis olabileceği düşüncesi ile tedavisi meropenem 3x1 gr/gün ve vankomisin 2x1 gr/gün olarak değiştirildi. Çekilen tüm batın ve toraks tomografisinde kardiyak situs inversus dışında patolojik bulgu saptanmadı. Ateşi devam eden hastada görme bozukluğu ve bilinç bulanıklığının tabloya eklenmesi üzerine lomber ponksiyon yapıldı. BOS bulguları menenjit ile uyumlu değildi. Kraniyal görüntülemede meningoensefalit lehine tutulum izlenmedi. Göz hastalıkları muayenesinde hastaya bilateral EE (açık yaz) ve sol ven kök tıkanıklığı ön tanıları ile bilateral intravitreal vankomisin (1 mg/0,1 ml)-seftazidim (2,25 mg/0 ml) ve ek olarak sol göze intravitreal bevacizumab (1,25 mg/0,05 ml) uygulandı. Takip eden günlerde hastanın ateşi düştü ve enflamatuvar parametreleri geriledi. Göz hastalıkları kliniği tarafından günlük takip edilen ve intravitreal tedavisi devam eden hastada enükleasyon ya da başka cerrahi işlem yapılması planlanmadı. Hastanın genel durumu günler içinde düzeldi. Meropenem ve vankomisin tedavisi 28 güne tamamlanan hasta enfeksiyon ve göz hastalıkları poliklinik kontrolüyle taburcu edildi. Sonuç: EE ise Salmonella enfeksiyonlarının seyri esnasında karşılaşılabilecek bir durumdur. Erken ve uygun tedavi, gözün kurtarılmasında önemli rol oynar. [ABSTRACT FROM AUTHOR]

Copyright of Mediterranean Journal of Infection, Microbes & Antimicrobials is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mediterranean Journal of Infection, Microbes & Antimicrobials is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Brucellosis is an important public health problem in Turkey as well as in the world. The disease manifests with non-specific symptoms such as fever, joint aches, and sweating, and doxycycline has an important place in its treatment. Doxycycline is a broad-spectrum tetracycline antibiotic used in the treatment and prophylaxis of various inflammatory and infectious disorders. Along with several systemic complications (i.e. esophagitis, hepatotoxicity, diarrhea), doxycycline is also known to have phototoxic effects. Photoonycolysis, rarely accompanying phototoxic reactions, is the detachment of the nail plaque from the nail bed with exposure to ultraviolet light. The aim of the current case report was to present a patient, who was placed on doxycycline therapy due to brucellosis and who developed photoonycolysis in all fingers of the hands. [ABSTRACT FROM AUTHOR]

Musculoskeletal infections, including septic arthritis, osteomyelitis, and soft tissue infections, are critical morbidity factors for children and adolescents. This study investigated the role of D-dimer levels for diagnosing childhood musculoskeletal infections. This single-center prospective study was initiated in April 2020 following approval from the local ethics committee. The study included 54 children, divided into the infection group ( n = 21), comprising patients who underwent surgical treatment for childhood musculoskeletal infections and had macroscopically visible purulent discharge during surgery, and the control group ( n = 33), comprising healthy children. In the infection group, the mean values of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), plasma D-dimer, and white blood cell (WBC) were 39.42 ± 27.00 mm/h, 101.50 ± 76.90 mg/l, 2.34 ± 2.59 mg/l, and 15.55 ± 6.86 × 10 9 /l, respectively. On comparison, the infection group showed higher levels of WBC, CRP, ESR, D-dimer, and neutrophil-to-lymphocyte ratio than the control group. When the D-dimer cutoff value of 0.43 mg/l was taken, it was observed that it had 95.2% sensitivity and 81.8% specificity. The area under curve (AUC) of the above-mentioned parameters calculated via receiver operating characteristic curves showed CRP levels as the optimum predictor of childhood musculoskeletal infections, followed by the ESR, plasma D-dimer, and WBC levels in descending order (AUC: 0.999, 0.997, 0.986, and 0.935, respectively). D-dimer is another test, which in combination with other conventional established tests (CRP and ESR) can be helpful in diagnosis of pediatric infection. We recommend the addition of D-Dimer to ESR, CRP, and WBC as a first-line investigation in cases with suspected pediatric musculoskeletal infections., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)

The patient was a 83-year- old male who worked as a farmer. He had complaints of weight loss, abdominal pain and joint pains for almost 5 months. Twenty days ago, the patient was checked at another hospital for complaints of occasional coughing and bloody sputum. He was treated with a diagnosis of pneumonia. His respiratory complaints were reduced, but there was no relief of his ongoing abdominal pain. Gastroduodenoscopy and colonoscopy were performed to examine for possible etiologies of continuous abdominal pain. Biopsies were taken from duodenal bulbus and second duodenal segment. Intense eosinophilic leukocyte infiltration and Strongyloides stercoralis larvae were observed in pathologic examination. The patient was successfully treated with albendazole 2x400 mg/day for 7+7 day.

Myiasis is one of the reasons for urogenital parasitosis in our country. Psychoda albipennis is a fly that leads to urogenital myiasis. In this case, a 28-year-old female with complaints of dysuria, nausea, vomiting, abdominal pain, and dropping larvae with urine was referred to our hospital. Larvae in the urine sample were macroscopically and microscopically examined. Subsequently, the patient was diagnosed with urogenital myiasis due to P. albipennis fourth phase larvae. The symptoms were relieved with antibiotic and urinal antiseptic treatments. A diagnosis of urogenital myiasis should be considered in patients with urogenital complaints.

Background: The aim of the present study was to determine relationship of ischemia-modified albumin (IMA) level, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) to appendicitis in children., Methods: Study included total of 63 patients who presented at hospital between May 2015 and November 2015. Of these, 30 were cases of appendicitis, and 33 were healthy control subjects. The groups were statistically similar in age and gender., Results: Receiver operating characteristic curve was evaluated for IMA, CRP, ESR, WBC, MPV, NLR, and PLR values in patients with appendicitis, and IMA was determined to have highest area under the curve value (0.991), followed by NLR (0.946), CRP (0.808), PLR (0.779), ESR (0.767), WBC (0.749), and MPV (0.583)., Conclusion: Use of NLR, PLR, IMA, and ESR values may be helpful in diagnosis of appendicitis, in addition to WBC and CRP values, lower right quadrant abdominal pain, and ultrasonography signs commonly used.