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350 results on '"Narayan, Raj K."'

62. Trigeminal Nerve Stimulation

Author

Li, Chunyan, primary, Chiluwal, Amrit, additional, Afridi, Adil, additional, Chaung, Wayne, additional, Powell, Keren, additional, Yang, Weng-Lang, additional, Wang, Ping, additional, and Narayan, Raj K., additional

Published
2019
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63. Prehospital Factors Associated with Discharge Outcomes: Baseline Data from the Andhra Pradesh Traumatic Brain Injury Project

Author

Ram, Kodanda, primary, VaraPrasad, Kadali, additional, Krishna, Murali K., additional, Kannan, Nithya, additional, Sundar, Venkataraman, additional, Joseph, Mathew, additional, Sinha, Virendar D., additional, Shukla, Dhaval, additional, Gururaj, Gopalakrishnan, additional, Narayan, Raj K., additional, Pattisapu, Jogi V., additional, and Vavilala, Monica S., additional

Published
2019
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77. A clinical trial of progesterone for severe traumatic brain injury

Author

Skolnick, Brett, Maas, Andrew I, Narayan, Raj K, Öhman, Juha, Lääketieteen yksikkö - School of Medicine, and University of Tampere

Subjects
Neurotieteet - Neurosciences
Abstract

BACKGROUND: Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase 3 randomized clinical trial. METHODS: We conducted a multinational placebo-controlled trial, in which 1195 patients, 16 to 70 years of age, with severe TBI (Glasgow Coma Scale score, ≤8 [on a scale of 3 to 15, with lower scores indicating a reduced level of consciousness] and at least one reactive pupil) were randomly assigned to receive progesterone or placebo. Dosing began within 8 hours after injury and continued for 120 hours. The primary efficacy end point was the Glasgow Outcome Scale score at 6 months after the injury. RESULTS: Proportional-odds analysis with covariate adjustment showed no treatment effect of progesterone as compared with placebo (odds ratio, 0.96; confidence interval, 0.77 to 1.18). The proportion of patients with a favorable outcome on the Glasgow Outcome Scale (good recovery or moderate disability) was 50.4% with progesterone, as compared with 50.5% with placebo. Mortality was similar in the two groups. No relevant safety differences were noted between progesterone and placebo. CONCLUSIONS: Primary and secondary efficacy analyses showed no clinical benefit of progesterone in patients with severe TBI. These data stand in contrast to the robust preclinical data and results of early single-center trials that provided the impetus to initiate phase 3 trials. (Funded by BHR Pharma; SYNAPSE ClinicalTrials.gov number, NCT01143064.). Nejm,free fulltext

Published
2014

88. Regional temperature and quantitative cerebral blood flow responses to cortical spreading depolarization in the rat.

Author

Chunyan Li, Narayan, Raj K., Ping Wang, and Hartings, Jed A.

Abstract

Regional temperature and quantitative regional cerebral blood flow responses to cortical spreading depolarization in the rat were continuously monitored in the same tissue using a microfabricated thermal diffusion sensor that recalibrates and measures in 5-s cycles. The regional cerebral blood flow response had four phases, including early hyperemia (peak: 226% of baseline; duration: 113.1 ± 14.4 s) and late oligemia (minimum: 57%, duration: 28.4 ± 3.7 min). Temperature rose with the start of the regional cerebral blood flow response to a peak increase of 0.28 ± 0.06°C and returned to baseline near the start of oligemia. This technology may be useful for multimodal monitoring in both the laboratory and clinic. [ABSTRACT FROM AUTHOR]

Published
2017
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94. Jacob Chandy

Author

Abraham, Jacob, primary, Mathai, K. V., additional, Rajshekhar, Vedantam, additional, and Narayan, Raj K., additional

Published
2010
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95. Clinical Evaluation of a Portable Near-Infrared Device for Detection of Traumatic Intracranial Hematomas

Author

Robertson, Claudia S., primary, Zager, Eric L., additional, Narayan, Raj K., additional, Handly, Neal, additional, Sharma, Alok, additional, Hanley, Daniel F., additional, Garza, Homero, additional, Maloney-Wilensky, Eileen, additional, Plaum, Justin M., additional, Koenig, Carolyn H., additional, Johnson, Anne, additional, and Morgan, Timothy, additional

Published
2010
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