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Existing ionic artificial muscles still require a technology breakthrough for much faster response speed, higher bending strain, and longer durability. Here, we report an MXene artificial muscle based on ionically cross-linked Ti3C2Tx with poly(3,4 ethylenedioxythiophene)-poly(styrenesulfonate), showing ultrafast rise time of within 1 s in DC responses, extremely large bending strain up to 1.37% in very low input voltage regime (0.1 to 1 V), long-term cyclic stability of 97% up to 18,000 cycles, markedly reduced phase delay, and very broad frequency bandwidth up to 20 Hz with good structural reliability without delamination under continuous electrical stimuli. These artificial muscles were successfully applied to make an origami-inspired narcissus flower robot as a wearable brooch and dancing butterflies and leaves on a tree as a kinetic art piece. These successful demonstrations elucidate the wide potential of MXene-based soft actuators for the next-generation soft robotic devices including wearable electronics and kinetic art pieces. [ABSTRACT FROM AUTHOR]

Mechanically bendable and flexible functionalities are urgently required for next‐generation battery systems that will be included in soft and wearable electronics, active sportswear, and origami‐based deployable space structures. However, it is very difficult to synthesize anode and cathode electrodes that have high energy density and structural reliability under large bending deformation. Here, vanadium oxide (V2O5) and nickel cobalt oxide (NiCo2O4) nanowire‐carbon fabric electrodes for highly flexible and bendable lithium ion batteries are reported. The vanadium oxide and nickel cobalt oxide nanowires were directly grown on plasma‐treated carbon fabric and were used as cathode and anode electrodes in a full cell lithium ion battery. Most importantly, a pre‐lithiation process was added to the nickel cobalt oxide nanowire anode to facilitate the construction of a full cell using symmetrically‐architectured nanowire‐carbon fabric electrodes. The highly bendable full cell based on poly(ethylene oxide) polymer electrolyte and room temperature ionic liquid shows high energy density of 364.2 Wh kg−1 at power density of 240 W kg−1, without significant performance degradation even under large bending deformations. These results show that vanadium oxide and lithiated nickel cobalt oxide nanowire‐carbon fabrics are a good combination for binder‐free electrodes in highly flexible lithium‐ion batteries. [ABSTRACT FROM AUTHOR]

Background: Transient receptor potential vanilloid type 1 (TRPV1) has been studied in human malignancies, but has not been studied in epithelial ovarian cancer (EOC). We, therefore, investigated the significance of TRPV1 and correlation with phosphatase and tension homolog (PTEN) in EOC., Materials and Methods: Immunohistochemical analyses for TRPV1 and PTEN were performed using a tissue microarray. Moreover, the role of TRPV1 in cell growth was assessed in a EOC cell line., Results: High TRPV1 expression and the combination of high TRPV1 and low PTEN expression were an independent prognostic factor for overall survival and disease-free survival. In vitro results demonstrated that knockdown of TRPV1 was associated with decreased cell viability and colony formation., Conclusion: There is a strong association between TRPV1 and PTEN and the combination of TRPV1 and PTEN is a strong indicator of prognostic predictor in EOC., (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Existing ionic artificial muscles still require a technology breakthrough for much faster response speed, higher bending strain, and longer durability. Here, we report an MXene artificial muscle based on ionically cross-linked Ti 3 C 2 T x with poly(3,4 ethylenedioxythiophene)-poly(styrenesulfonate), showing ultrafast rise time of within 1 s in DC responses, extremely large bending strain up to 1.37% in very low input voltage regime (0.1 to 1 V), long-term cyclic stability of 97% up to 18,000 cycles, markedly reduced phase delay, and very broad frequency bandwidth up to 20 Hz with good structural reliability without delamination under continuous electrical stimuli. These artificial muscles were successfully applied to make an origami-inspired narcissus flower robot as a wearable brooch and dancing butterflies and leaves on a tree as a kinetic art piece. These successful demonstrations elucidate the wide potential of MXene-based soft actuators for the next-generation soft robotic devices including wearable electronics and kinetic art pieces., (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

A new treatment facility for heavy ion therapy since 2010 was constructed. In the broad beam, a range shifter, ridge filter and multi leaf collimator (MLC) for the generation of the spread-out Bragg peak is used. In this case, secondary neutrons produced by the interactions of the ion field with beam-modifying devices (e.g. double-scattering system, beam shaping collimators and range compensators) are very important for patient safety. Therefore, these components must be carefully examined in the context of secondary neutron yield and associated secondary cancer risk. In this article, Monte Carlo simulation has been carried out with the FLUktuierende KAskade particle transport code, the fluence and distribution of neutron generation and the neutron dose equivalent from the broad beam components are compared using carbon and proton beams. As a result, it is confirmed that the yield of neutron production using a carbon beam from all components of the broad beam was higher than using a proton beam. The ambient dose by neutrons per heavy ion and proton ion from the MLC surface was 0.12-0.18 and 0.0067-0.0087 pSv, respectively, which shows that heavy ions generate more neutrons than protons. However, ambient dose per treatment 2 Gy, which means physical dose during treatment by ion beam, is higher than carbon beam because proton therapy needs more beam flux to make 2-Gy prescription dose. Therefore, the neutron production from the MLC, which is closed to the patient, is a very important parameter for patient safety., (© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)