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752 results on '"Nakamoto S"'

53. Potential feedbacks between Pacific Ocean ecosystems and interdecadal climate variations

Author

Miller, A. J., Alexander, M. A., Boer, G. J., Chai, F., Denman, K., Erickson, D. J., Frouin, R., Gabric, A. J., Laws, E. A., Lewis, M. R., Liu, Z., Murtugudde, R., Nakamoto, S., Neilson, D. J., Norris, J. R., Ohlmann, J. C., Perry, R. I., Schneider, N., Shell, K. M., Timmermann, Axel, Miller, A. J., Alexander, M. A., Boer, G. J., Chai, F., Denman, K., Erickson, D. J., Frouin, R., Gabric, A. J., Laws, E. A., Lewis, M. R., Liu, Z., Murtugudde, R., Nakamoto, S., Neilson, D. J., Norris, J. R., Ohlmann, J. C., Perry, R. I., Schneider, N., Shell, K. M., and Timmermann, Axel

Abstract

Oceanic ecosystems altered by interdecadal climate variability may provide a feedback to the physical climate by phytoplankton affecting heat fluxes into the upper ocean and dimethylsulfide fluxes into the atmosphere

Published
2003
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64. Quantification of hepatitis C virus in patients treated with peginterferon‐alfa 2a plus ribavirin treatment by COBAS TaqMan HCV test

Author

Kanda, T., primary, Imazeki, F., additional, Yonemitsu, Y., additional, Mikami, S., additional, Takada, N., additional, Nishino, T., additional, Takashi, M., additional, Tsubota, A., additional, Kato, K., additional, Sugiura, N., additional, Tawada, A., additional, Wu, S., additional, Tanaka, T., additional, Nakamoto, S., additional, Mikata, R., additional, Tada, M., additional, Chiba, T., additional, Kurihara, T., additional, Arai, M., additional, Fujiwara, K., additional, Kanai, F., additional, and Yokosuka, O., additional

Published
2010
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76. Indications for the use of endoscopic mucosal resection for early gastric cancer in Japan: a comparative study with endoscopic submucosal dissection

Author

Nakamoto, S., primary, Sakai, Y., additional, Kasanuki, J., additional, Kondo, F., additional, Ooka, Y., additional, Kato, K., additional, Arai, M., additional, Suzuki, T., additional, Matsumura, T., additional, Bekku, D., additional, Ito, K., additional, Tanaka, T., additional, and Yokosuka, O., additional

Published
2009
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84. hTR repressor-related gene on human chromosome 10p15.1

Author

Miura, N, primary, Onuki, N, additional, Rathi, A, additional, Virmani, A, additional, Nakamoto, S, additional, Kishimoto, Y, additional, Murawaki, Y, additional, Kawasaki, H, additional, Hasegawa, J, additional, Oshimura, M, additional, Travis, W D, additional, and Gazdar, A F, additional

Published
2001
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91. Chlorophyll Control of Surface Temperature in the Arabian Sea

Author

FROUIN, Robert and NAKAMOTO, S.

Abstract

[ABSTRACT] A general ocean circulation model is used to investigate the effect of solar radiation absorption by phytoplankton on surface temperature. The model, an updated version of Oberhuber's (1993) OPYC model, solves primitive equations, uses isopycnals as Lagrangian vertical coordinates, and includes a fully coupled mixed layer. The vertical profile of heating rate is parameterized as a function of remotely-sensed chlorophyll concentration. The model is run for 50 years without chlorophyll (control run) and an additional 10 years with chlorophyll (experimental run). The difference between experimental and control runs gives the biological effect. In January, sea surface temperature anomalies are positive in the northern hemisphere and negative in the southern hemisphere. In July, the opposite result is obtained. This suggests that, on a global scale, phytoplankton acts at moderating meridional temperature gradients. In the Arabian Sea, along a zonal strip centered at 20N, positive anomalies reaching 0.6K appear twice a year, from March through June and from September through November, and are associated with the two maxima of solar radiation over the annual cycle. The anomalies are smaller by 0.2K during the fall inter-monsoon season despite a 5-fold increase in chlorophyll abundance, because of reduced solar radiation. Increased chlorophyll during the southwest monsoon causes surface warming and sub-surface cooling consistent with JGOFS observations during the 1994-1995 Arabian Sea experiment.

Published
1999

98. Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4.

Author

Tamura R, Kanda T, Imazeki F, Wu S, Nakamoto S, Tanaka T, Arai M, Fujiwara K, Saito K, Roger T, Wakita T, Shirasawa H, Yokosuka O, Tamura, Ryo, Kanda, Tatsuo, Imazeki, Fumio, Wu, Shuang, Nakamoto, Shingo, Tanaka, Takeshi, and Arai, Makoto

Abstract

Background: Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to modulate multiple cellular processes, including apoptosis. The aim of this study was to assess the effects of HCV NS5A on apoptosis induced by Toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS).Methods: Apoptotic responses to TLR4 ligands and the expression of molecules involved in TLR signaling pathways in human hepatocytes were examined with or without expression of HCV NS5A.Results: HCV NS5A protected HepG2 hepatocytes against LPS-induced apoptosis, an effect linked to reduced TLR4 expression. A similar downregulation of TLR4 expression was observed in Huh-7-expressing genotype 1b and 2a. In agreement with these findings, NS5A inhibited the expression of numerous genes encoding for molecules involved in TLR4 signaling, such as CD14, MD-2, myeloid differentiation primary response gene 88, interferon regulatory factor 3, and nuclear factor-κB2. Consistent with a conferred prosurvival advantage, NS5A diminished the poly(adenosine diphosphate-ribose) polymerase cleavage and the activation of caspases 3, 7, 8, and 9 and increased the expression of anti-apoptotic molecules Bcl-2 and c-FLIP.Conclusions: HCV NS5A downregulates TLR4 signaling and LPS-induced apoptotic pathways in human hepatocytes, suggesting that disruption of TLR4-mediated apoptosis may play a role in the pathogenesis of HCV infection. [ABSTRACT FROM AUTHOR]

Published
2011
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