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1,289 results on '"Nakamae, Hirohisa"'

53. Cytomegalovirus reactivation is associated with an increased risk of late-onset invasive aspergillosis independently of grade II–IV acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation: JSTCT Transplant Complications Working Group

Author

Kimura, Shun-ichi, Tamaki, Masaharu, Okinaka, Keiji, Seo, Sachiko, Uchida, Naoyuki, Igarashi, Aiko, Ozawa, Yukiyasu, Ikegame, Kazuhiro, Eto, Tetsuya, Tanaka, Masatsugu, Shiratori, Souichi, Nakamae, Hirohisa, Sawa, Masashi, Kawakita, Toshiro, Onizuka, Makoto, Fukuda, Takahiro, Atsuta, Yoshiko, Kanda, Yoshinobu, and Nakasone, Hideki

Published
2021
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54. Impact of HLA disparity on the risk of overall mortality in patients with grade II–IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation

Author

Fuji, Shigeo, Hakoda, Akitoshi, Kanda, Junya, Murata, Makoto, Terakura, Seitaro, Inamoto, Yoshihiro, Uchida, Naoyuki, Toya, Takashi, Eto, Tetsuya, Nakamae, Hirohisa, Ikegame, Kazuhiro, Tanaka, Masatsugu, Kawakita, Toshiro, Kondo, Tadakazu, Miyamoto, Toshihiro, Fukuda, Takahiro, Ichinohe, Tatsuo, Kimura, Takafumi, Atsuta, Yoshiko, Shintani, Ayumi, and Morishima, Satoko

Published
2021
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56. Impacts of Posttransplant Cyclophosphamide Dose on Graft-versus-Leukemia Effects via HLA-B Leader in HLA-Haploidentical Peripheral Blood Stem Cell Transplantation

Author

Moriguchi, Makoto, primary, Ido, Kentaro, additional, Okamura, Hiroshi, additional, Nakamae, Mika, additional, Sakatoku, Kazuki, additional, Makuuchi, Yosuke, additional, Kuno, Masatomo, additional, Takakuwa, Teruhito, additional, Hirose, Asao, additional, Nishimoto, Mitsutaka, additional, Nakashima, Yasuhiro, additional, Koh, Hideo, additional, Hino, Masayuki, additional, and Nakamae, Hirohisa, additional

Published
2024
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57. Improved survival of patients with aggressive ATL by increased use of allo-HCT: a prospective observational study

Author

Ito, Ayumu, Nakano, Nobuaki, Tanaka, Takashi, Fuji, Shigeo, Makiyama, Junya, Inoue, Yoshitaka, Choi, Ilseung, Nakamae, Hirohisa, Nagafuji, Koji, Takase, Ken, Machida, Shinichiro, Takahashi, Tsutomu, Sawayama, Yasushi, Kamimura, Tomohiko, Kato, Koji, Kawakita, Toshiro, Ogata, Masao, Sakai, Rika, Shiratori, Souichi, Uchimaru, Kaoru, Inamoto, Yoshihiro, Utsunomiya, Atae, and Fukuda, Takahiro

Published
2021
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58. Increasing numbers of CD19 + CD24highCD38high regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia

Author

Hayashi, Tetsuya, Nakamae, Hirohisa, Takeda, Shinichi, Nakashima, Yasuhiro, Koh, Hideo, Nishimoto, Mitsutaka, Okamura, Hiroshi, Nanno, Satoru, Makuuchi, Yosuke, Kuno, Masatomo, Nakamae, Mika, Hirose, Asao, and Hino, Masayuki

Published
2021
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59. Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome in adolescent and young adult patients

Author

Shimomura, Yoshimitsu, Hara, Masahiko, Konuma, Takaaki, Itonaga, Hidehiro, Doki, Noriko, Ozawa, Yukiyasu, Eto, Tetsuya, Uchida, Naoyuki, Aoki, Jun, Kato, Jun, Onishi, Yasushi, Takahashi, Satoshi, Fukushima, Kentaro, Nakamae, Hirohisa, Kawakita, Toshiro, Tanaka, Junji, Fukuda, Takahiro, Atsuta, Yoshiko, Ishikawa, Takayuki, and Ishiyama, Ken

Published
2021
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60. Comparison of Haploidentical Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus Umbilical Cord Blood Transplantation in Adult Patients with Aplastic Anemia

Author

Onishi, Yasushi, Mori, Takehiko, Yamazaki, Hirohito, Hiramoto, Nobuhiro, Zaimoku, Yoshitaka, Kanaya, Minoru, Matsue, Kosei, Onizuka, Makoto, Aotsuka, Nobuyuki, Uchida, Naoyuki, Onodera, Koichi, Kanda, Junya, Nakamae, Hirohisa, Yamamoto, Ryusuke, Kuriyama, Takuro, Kimura, Takafumi, Ichinohe, Tatsuo, and Atsuta, Yoshiko

Published
2023
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61. Expression of activated integrin β7 in multiple myeloma patients

Author

Hosen, Naoki, Yoshihara, Satoshi, Takamatsu, Hiroyuki, Ri, Masaki, Nagata, Yasuyuki, Kosugi, Hiroshi, Shimomura, Yoshimitsu, Hanamura, Ichiro, Fuji, Shigeo, Minauchi, Koichiro, Kuroda, Junya, Suzuki, Rikio, Nishimura, Noriko, Uoshima, Nobuhiko, Nakamae, Hirohisa, Kawano, Yawara, Mizuno, Ishikazu, Gomyo, Hiroshi, Suzuki, Kenshi, Ozaki, Shuji, Nakamura, Shingen, Imai, Yoichi, Kizaki, Masahiro, Negoro, Eiju, Handa, Hiroshi, and Iida, Shinsuke

Published
2021
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63. Effect of methotrexate dose in graft-versus-host disease prophylaxis after single-unit cord blood transplantation in adult acute myeloid leukemia

Author

Terakura, Seitaro, Kuwatsuka, Yachiyo, Sugita, Junichi, Takahashi, Satoshi, Ozawa, Yukiyasu, Ozeki, Kazutaka, Yoshioka, Satoshi, Nakamae, Hirohisa, Kawakita, Toshiro, Sawa, Masashi, Morishige, Satoshi, Najima, Yuho, Katsuoka, Yuna, Sakaida, Emiko, Kouzai, Yasuji, Kimura, Takafumi, Ichinohe, Tatsuo, Fukuda, Takahiro, Atsuta, Yoshiko, Murata, Makoto, and Teshima, Takanori

Published
2021
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64. Chromosomal defects and survival in patients with adult T-cell leukemia/lymphoma after allogeneic HSCT

Author

Nakano, Nobuaki, Utsunomiya, Atae, Matsuo, Keitaro, Yoshida, Noriaki, Seto, Masao, Ohshima, Kouichi, Fujiwara, Hiroshi, Fuji, Shigeo, Takatsuka, Yoshifusa, Ito, Ayumu, Miyamoto, Toshihiro, Suehiro, Youko, Nakamae, Hirohisa, Sawayama, Yasushi, Yuasa, Mitsuhiro, Miyazaki, Yasuhiko, Ota, Shuichi, Imada, Kazunori, Fukuda, Takahiro, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Kato, Koji

Published
2021
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65. Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

Author

Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, null, null, Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, and null, null

Abstract

PURPOSEAllogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of FLT3 (FLT3-ITD) AML. These patients are routinely treated with a FLT3 inhibitor after HCT, but there is limited evidence to support this. Accordingly, we conducted a randomized trial of post-HCT maintenance with the FLT3 inhibitor gilteritinib (ClinicalTrials.gov identifier: NCT02997202) to determine if all such patients benefit or if detection of measurable residual disease (MRD) could identify those who might benefit.METHODSAdults with FLT3-ITD AML in first remission underwent HCT and were randomly assigned to placebo or 120 mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival (RFS). Secondary end points included overall survival (OS) and the effect of MRD pre- and post-HCT on RFS and OS.RESULTSThree hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided P =.0518). However, 50.5% of participants had MRD detectable pre- or post-HCT, and, in a prespecified subgroup analysis, gilteritinib was beneficial in this population (HR, 0.515 [95% CI, 0.316 to 0.838]; P =.0065). Those without detectable MRD showed no benefit (HR, 1.213 [95% CI, 0.616 to 2.387]; P =.575).CONCLUSIONAlthough the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable FLT3-ITD MRD pre- or post-HCT who received gilteritinib treatment. To our knowledge, these data are among the first to support the effectiveness of MRD-based post-HCT therapy.

Published
2024

67. RhD mismatch does not affect haematopoietic recovery, graft‐versus‐host disease and survival in allogeneic haematopoietic cell transplantation: A Japanese registry‐based study.

Author

Konuma, Takaaki, Uchida, Naoyuki, Takeda, Wataru, Doki, Noriko, Yoshihara, Satoshi, Nishida, Tetsuya, Kuriyama, Takuro, Tanaka, Masatsugu, Ohigashi, Hiroyuki, Nakamae, Hirohisa, Katayama, Yuta, Ota, Shuichi, Hashii, Yoshiko, Ishimaru, Fumihiko, Fukuda, Takahiro, Ohbiki, Marie, and Atsuta, Yoshiko

Subjects
CELL transplantation, GRAFT versus host disease, OVERALL survival, HEMATOPOIETIC stem cell transplantation, STEM cell transplantation, ABO blood group system, ERYTHROCYTES
Abstract

Background and Objectives: ABO blood group mismatch between the donor and the recipient can affect the success of the transplant as well as problems with the red blood cells during allogeneic haematopoietic cell transplantation (HCT). However, the impact of the Rhesus (Rh) D mismatch on transplant outcomes in allogeneic HCT has been poorly elucidated. Materials and Methods: We retrospectively evaluated the impact of the RhD mismatch on post‐transplant outcomes in 64,923 patients who underwent allogeneic HCT between 2000 and 2021 using a Japanese registry database. Results: Out of the whole group, 64,293, 322, 270 and 38 HCTs were done when the recipient or donor was RhD‐mismatched with (+/+), (−/+), (+/−) or (−/−) combinations. The difference in RhD between recipient/donor (−/+), (+/−) and (−/−) did not affect haematopoietic recovery, acute and chronic graft‐versus‐host disease (GVHD), overall survival (OS), non‐relapse mortality (NRM) or relapse when RhD (+/+) was used as the reference group in multivariate analysis. Conclusion: Our registry‐based study demonstrated that RhD mismatch between recipient and donor did not significantly impact haematopoietic recovery, GVHD, OS, NRM or relapse after allogeneic HCT. These data suggest that RhD mismatches may not need to be avoided for recipient and donor combinations in allogeneic HCT. [ABSTRACT FROM AUTHOR]

Published
2024
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70. Treatment-free remission after first-line dasatinib discontinuation in patients with chronic myeloid leukaemia (first-line DADI trial): a single-arm, multicentre, phase 2 trial

Author

Kimura, Shinya, Imagawa, Jun, Murai, Kazunori, Hino, Masayuki, Kitawaki, Toshio, Okada, Masaya, Tanaka, Hideo, Shindo, Motohiro, Kumagai, Takashi, Ikezoe, Takayuki, Uoshima, Nobuhiko, Sato, Tsutomu, Watanabe, Reiko, Kowata, Shugo, Hayakawa, Masaya, Hosoki, Takaaki, Ikeda, Kazuhiko, Kobayashi, Tsutomu, Kakinoki, Yasutaka, Nishimoto, Tetsuo, Takezako, Naoki, Shibayama, Hirohiko, Takaori-Kondo, Akifumi, Nakamae, Hirohisa, Kawaguchi, Atsushi, Ureshino, Hiroshi, Sakamoto, Junichi, and Ishida, Yoji

Published
2020
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71. Time-Varying Effects of Graft Type on Outcomes for Patients with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation

Author

Yanada, Masamitsu, Konuma, Takaaki, Yamasaki, Satoshi, Kuwatsuka, Yachiyo, Masuko, Masayoshi, Tanaka, Masatsugu, Ozawa, Yukiyasu, Toya, Takashi, Fukuda, Takahiro, Ota, Shuichi, Sawa, Masashi, Uchida, Naoyuki, Nakamae, Hirohisa, Eto, Tetsuya, Kanda, Junya, Takanashi, Minoko, Kanda, Yoshinobu, Atsuta, Yoshiko, and Yano, Shingo

Published
2020
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72. Hematopoietic Stem Cell Transplantation in Solid Organ Recipients with Emphasis on Transplant Complications: A Nationwide Retrospective Survey on Behalf of the Japan Society for Hematopoietic Stem Cell Transplantation Transplant Complications Working Group

Author

Shinohara, Akihito, Oshima, Kumi, Fuji, Shigeo, Umeda, Katsutsugu, Kako, Shinichi, Kurokawa, Mineo, Tsukada, Nobuhiro, Kasai, Masanobu, Kondo, Takakazu, Hashii, Yoshiko, Nakamae, Hirohisa, Ikegame, Kazuhiro, Kosaka, Yoshiyuki, Shimada, Akira, Nawa, Yuichiro, Makoto, Yoshimitsu, Yoshiko, Atsuta, Fukuda, Takahiro, Tanaka, Junji, and Ogata, Masao

Published
2020
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73. Comparison of long-term outcomes after first HLA-mismatched unrelated donor transplantation with single unrelated cord blood transplantation using reduced-intensity or reduced-toxicity conditioning

Author

Kuno, Masatomo, primary, Koh, Hideo, additional, Ido, Kentaro, additional, Sakatoku, Kazuki, additional, Makuuchi, Yosuke, additional, Takakuwa, Teruhito, additional, Hirose, Asao, additional, Okamura, Hiroshi, additional, Nishimoto, Mitsutaka, additional, Nakashima, Yasuhiro, additional, Nakamae, Mika, additional, Hino, Masayuki, additional, and Nakamae, Hirohisa, additional

Published
2024
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74. Predicting non-relapse mortality following allogeneic hematopoietic cell transplantation during first remission of acute myeloid leukemia

Author

Yanada, Masamitsu, Konuma, Takaaki, Mizuno, Shohei, Saburi, Masuho, Shinohara, Akihito, Tanaka, Masatsugu, Marumo, Atsushi, Sawa, Masashi, Uchida, Naoyuki, Ozawa, Yukiyasu, Onizuka, Makoto, Yoshioka, Satoshi, Nakamae, Hirohisa, Kondo, Tadakazu, Kimura, Takafumi, Kanda, Junya, Fukuda, Takahiro, Atsuta, Yoshiko, Nakasone, Hideki, and Yano, Shingo

Published
2021
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75. Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study

Author

Kurosawa, Shuhei, primary, Shimomura, Yoshimitsu, additional, Ishiyama, Ken, additional, Fuse, Kyoko, additional, Shimazu, Yutaka, additional, Doki, Noriko, additional, Uchida, Naoyuki, additional, Tanaka, Masatsugu, additional, Takahashi, Satoshi, additional, Sakurai, Masatoshi, additional, Kobayashi, Hikaru, additional, Katayama, Yuta, additional, Takada, Satoru, additional, Ozeki, Kazutaka, additional, Nakamae, Hirohisa, additional, Ishimaru, Fumihiko, additional, Kanda, Yoshinobu, additional, Ichinohe, Tatsuo, additional, Atsuta, Yoshiko, additional, and Itonaga, Hidehiro, additional

Published
2023
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76. Effect of conditioning regimens and GVHD prophylaxis on the outcomes of umbilical cord blood transplantation performed with cyclophosphamide/total-body irradiation-based regimens

Author

Imahashi, Nobuhiko, primary, Kurita, Naoki, additional, Konuma, Takaaki, additional, Takahashi, Satoshi, additional, Nishida, Tetsuya, additional, Tanaka, Masatsugu, additional, Nakamae, Hirohisa, additional, Kawakita, Toshiro, additional, Ota, Shuichi, additional, Doki, Noriko, additional, Onishi, Yasushi, additional, Sawa, Masashi, additional, Ozeki, Kazutaka, additional, Hiramoto, Nobuhiro, additional, Onizuka, Makoto, additional, Ishimaru, Fumihiko, additional, Ichinohe, Tatsuo, additional, Atsuta, Yoshiko, additional, and Kanda, Junya, additional

Published
2023
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77. Invasive fungal infection caused by Blastobotrys mokoenaii in an immunocompromised patient with acute myeloid leukemia: A case report

Author

Shiomi, Ichiro, primary, Makuuchi, Yosuke, additional, Noura, Ikue, additional, Kakuno, Shigeki, additional, Niki, Makoto, additional, Kaimi, Yuto, additional, Ido, Kentaro, additional, Sakatoku, Kazuki, additional, Kuno, Masatomo, additional, Takakuwa, Teruhito, additional, Okamura, Hiroshi, additional, Nishimoto, Mitsutaka, additional, Nakashima, Yasuhiro, additional, Nakamae, Mika, additional, Kakeya, Hiroshi, additional, Kohashi, Kenichi, additional, Hino, Masayuki, additional, and Nakamae, Hirohisa, additional

Published
2023
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79. Effect of Graft-versus-Host Disease on Post-Transplantation Outcomes following Single Cord Blood Transplantation Compared with Haploidentical Transplantation with Post-Transplantation Cyclophosphamide for Adult Acute Myeloid Leukemia

Author

Konuma, Takaaki, Matsuda, Kensuke, Shimomura, Yoshimitsu, Tanoue, Susumu, Sugita, Junichi, Inamoto, Yoshihiro, Hirayama, Masahiro, Ara, Takahide, Nakamae, Hirohisa, Ota, Shuichi, Maruyama, Yumiko, Eto, Tetsuya, Uchida, Naoyuki, Tanaka, Masatsugu, Ishiwata, Kazuya, Koi, Satoshi, Takahashi, Satoshi, Ozawa, Yukiyasu, Onizuka, Makoto, Kanda, Yoshinobu, Kimura, Takafumi, Ichinohe, Tatsuo, Atsuta, Yoshiko, Kanda, Junya, and Yanada, Masamitsu

Published
2023
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83. Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant Complications Working Group of Japan Society for Hematopoietic Cell Transplantation

Author

Fuji, Shigeo, Oshima, Kumi, Ohashi, Kazuteru, Sawa, Masashi, Saito, Takeshi, Eto, Tetsuya, Tanaka, Masatsugu, Onizuka, Makoto, Nakamae, Hirohisa, Shiratori, Souichi, Ozawa, Yukiyasu, Hidaka, Michihiro, Nagamura-Inoue, Tokiko, Tanaka, Hidenori, Fukuda, Takahiro, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Ogata, Masao

Published
2020
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87. First complete remission favours haploidentical haematopoietic stem cell transplantation with post‐transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia.

Author

Jo, Tomoyasu, Ueda, Tomoaki, Akahoshi, Yu, Kondo, Tadakazu, Uchida, Naoyuki, Tanaka, Masatsugu, Nakamae, Hirohisa, Doki, Noriko, Ota, Shuichi, Sawa, Masashi, Ohigashi, Hiroyuki, Maruyama, Yumiko, Takayama, Nobuyuki, Nishida, Tetsuya, Hiramoto, Nobuhiro, Katayama, Yuta, Kanda, Yoshinobu, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Arai, Yasuyuki

Subjects
CORD blood transplantation, HEMATOPOIETIC stem cell transplantation, LYMPHOBLASTIC leukemia, ACUTE leukemia, CORD blood
Abstract

Summary: To assess the benefits of HLA‐haploidentical haematopoietic stem cell transplantation using post‐transplant cyclophosphamide (PTCy‐haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy‐haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy‐haplo was associated with a significantly higher relapse rate, but lower non‐relapse mortality, which results in overall survival and disease‐free survival, comparable to those of UCB. Among patients in CR1, PTCy‐haplo showed a significantly higher survival than UCB regardless of the CD34+ cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL. [ABSTRACT FROM AUTHOR]

Published
2024
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89. Development and evaluation of a rapid one-step high sensitivity real-time quantitative PCR system for minor BCR-ABL (e1a2) test in Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)

Author

Hidaka, Michihiro, primary, Inokuchi, Koiti, additional, Uoshima, Nobuhiko, additional, Takahashi, Naoto, additional, Yoshida, Nao, additional, Ota, Shuichi, additional, Nakamae, Hirohisa, additional, Iwasaki, Hiromi, additional, Watanabe, Kenichiro, additional, Kosaka, Yoshiyuki, additional, Komatsu, Norio, additional, Meguro, Kuniaki, additional, Najima, Yuho, additional, Eto, Tetsuya, additional, Kondo, Takeshi, additional, Kimura, Shinya, additional, Yoshida, Chikashi, additional, Ishikawa, Yuichi, additional, Sawa, Masashi, additional, Hata, Tomoko, additional, Horibe, Keizo, additional, Iida, Hiroatsu, additional, Shimomura, Takeshi, additional, Dobashi, Nobuaki, additional, Sugiura, Isamu, additional, Makiyama, Junya, additional, Miyagawa, Naoyuki, additional, Sato, Asuka, additional, Ito, Ryuta, additional, Matsumura, Itaru, additional, Kanakura, Yuzuru, additional, and Naoe, Tomoki, additional

Published
2023
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90. Hematopoietic stem cell transplantation from haploidentical offspring donors using post‐transplant cyclophosphamide versus human leukocyte antigen‐matched siblings in older patients with myelodysplastic syndrome

Author

Shimomura, Yoshimitsu, primary, Kitamura, Tetsuhisa, additional, Konuma, Takaaki, additional, Nakaya, Yosuke, additional, Doki, Noriko, additional, Sawa, Masashi, additional, Nakamae, Hirohisa, additional, Eto, Tetsuya, additional, Nishida, Tetsuya, additional, Ohigashi, Hiroyuki, additional, Ota, Shuichi, additional, Onizuka, Makoto, additional, Hiramoto, Nobuhiro, additional, Kawakita, Toshiro, additional, Kanda, Junya, additional, Ichinohe, Tatsuo, additional, Atsuta, Yoshiko, additional, and Itonaga, Hidehiro, additional

Published
2023
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91. Outcomes of allogeneic hematopoietic cell transplantation under letermovir prophylaxis for cytomegalovirus infection

Author

Takenaka, Katsuto, primary, Fuji, Shigeo, additional, Matsukawa, Toshihiro, additional, Uchida, Naoyuki, additional, Kobayashi, Takeshi, additional, Tanaka, Masatsugu, additional, Ara, Takahide, additional, Ikegame, Kazuhiro, additional, Ozawa, Yukiyasu, additional, Kanda, Yoshinobu, additional, Sawa, Masashi, additional, Maruyama, Yumiko, additional, Fukuda, Takahiro, additional, Nakamae, Hirohisa, additional, Kimura, Takafumi, additional, Ogata, Masao, additional, Seo, Sachiko, additional, Atsuta, Yoshiko, additional, Matsuo, Keitaro, additional, and Nakasone, Hideki, additional

Published
2023
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92. Effect of graft-versus-host disease on outcomes of HLA-haploidentical peripheral blood transplantation using post-transplant cyclophophamide

Author

Shimomura, Yoshimitsu, primary, Komukai, Sho, additional, Kitamura, Tetsuhisa, additional, Sobue, Tomotaka, additional, Akahoshi, Yu, additional, Kanda, Junya, additional, Ohigashi, Hiroyuki, additional, Nakamae, Hirohisa, additional, Hiramoto, Nobuhiro, additional, Nagafuji, Koji, additional, Tanaka, Takashi, additional, Eto, Tetsuya, additional, Ota, Shuichi, additional, Maruyama, Yumiko, additional, Akasaka, Takashi, additional, Matsuoka, Ken-ichi, additional, Mori, Yasuo, additional, Fukuda, Takahiro, additional, Atsuta, Yoshiko, additional, and Terakura, Seitaro, additional

Published
2023
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93. The prognosis and risk factors for patients with complex karyotype myelodysplastic syndrome undergoing allogeneic haematopoietic stem cell transplantation

Author

Shimomura, Yoshimitsu, primary, Komukai, Sho, additional, Kitamura, Tetsuhisa, additional, Tachibana, Takayoshi, additional, Kurosawa, Shuhei, additional, Itonaga, Hidehiro, additional, Tsukamoto, Shokichi, additional, Doki, Noriko, additional, Katayama, Yuta, additional, Ito, Ayumu, additional, Sawa, Masashi, additional, Ueda, Yasunori, additional, Nakamae, Hirohisa, additional, Nawa, Yuichiro, additional, Tanaka, Masatsugu, additional, Arai, Yasuyuki, additional, Ota, Shuichi, additional, Kataoka, Keisuke, additional, Nishida, Tetsuya, additional, Kanda, Junya, additional, Fukuda, Takahiro, additional, Atsuta, Yoshiko, additional, and Ishiyama, Ken, additional

Published
2023
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94. HLA-haploidentical Peripheral Blood Stem Cell Transplantation with Post-transplant Cyclophosphamide versus HLA-matched Unrelated Donor Transplantation for Myelodysplastic Syndrome

Author

Nakaya, Yosuke, primary, Koh, Hideo, additional, Konuma, Takaaki, additional, Shimomura, Yoshimitsu, additional, Ishiyama, Ken, additional, Itonaga, Hidehiro, additional, Hino, Masayuki, additional, Doki, Noriko, additional, Nishida, Tetsuya, additional, Ohigashi, Hiroyuki, additional, Matsuoka, Ken-ichi, additional, Kanda, Yoshinobu, additional, Maruyama, Yumiko, additional, Sawa, Masashi, additional, Eto, Tetsuya, additional, Hiramoto, Nobuhiro, additional, Fukuda, Takahiro, additional, Atsuta, Yoshiko, additional, and Nakamae, Hirohisa, additional

Published
2023
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95. Ibrutinib Induces a Dramatic Improvement for Idiopathic Refractory Ascites Following Allogeneic Hematopoietic Cell Transplantation

Author

Tazoe, Kumiyo, primary, Nishimoto, Mitsutaka, additional, Yamamoto, Akira, additional, Makuuchi, Yosuke, additional, Kuno, Masatomo, additional, Okamura, Hiroshi, additional, Nakashima, Yasuhiro, additional, Tanaka, Sayaka, additional, Ohsawa, Masahiko, additional, Hino, Masayuki, additional, and Nakamae, Hirohisa, additional

Published
2023
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96. Favorable Outcome with Conditioning Regimen of Flu/Bu4/Mel in Acute Myeloid Leukemia Patients in Remission Undergoing Cord Blood Transplantation

Author

Mizuno, Shohei, Takami, Akiyoshi, Kawamura, Koji, Shimomura, Yoshimitsu, Arai, Yasuyuki, Konuma, Takaaki, Ozawa, Yukiyasu, Sawa, Masashi, Ota, Shuichi, Takahashi, Satoshi, Anzai, Naoyuki, Hiramoto, Nobuhiro, Onizuka, Makoto, Nakamae, Hirohisa, Tanaka, Masatsugu, Murata, Makoto, Kimura, Takafumi, Kanda, Junya, Fukuda, Takahiro, Atsuta, Yoshiko, and Yanada, Masamitsu

Published
2022
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98. A noninvasive diagnostic approach using per-rectal portal scintigraphy for sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation

Author

Okamura, Hiroshi, Koh, Hideo, Takakuwa, Teruhito, Ido, Kentaro, Makuuchi, Yosuke, Ine, Shoji, Nanno, Satoru, Nakashima, Yasuhiro, Nakane, Takahiko, Jogo, Atsushi, Yamamoto, Akira, Hamuro, Masao, Kotani, Kohei, Kawabe, Joji, Higashiyama, Shigeaki, Yoshida, Atsushi, Shiomi, Susumu, Ohsawa, Masahiko, Hino, Masayuki, and Nakamae, Hirohisa

Published
2020
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99. Allogeneic Hematopoietic Stem Cell Transplantation for Adult Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia in Second Complete Remission

Author

Kaito, Satoshi, Kurosawa, Shuhei, Najima, Yuho, Sakaida, Emiko, Shingai, Naoki, Fukuda, Takahiro, Tachibana, Takayoshi, Uchida, Naoyuki, Ozawa, Yukiyasu, Sawa, Masashi, Nakazawa, Hideyuki, Ota, Shuichi, Kato, Jun, Nakamae, Hirohisa, Katayama, Yuta, Eto, Tetsuya, Tanaka, Junji, Kanda, Yoshinobu, Atsuta, Yoshiko, Arai, Yasuyuki, and Kako, Shinichi

Published
2022
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100. Final 3-year Results of the Dasatinib Discontinuation Trial in Patients With Chronic Myeloid Leukemia Who Received Dasatinib as a Second-line Treatment

Author

Okada, Masaya, Imagawa, Jun, Tanaka, Hideo, Nakamae, Hirohisa, Hino, Masayuki, Murai, Kazunori, Ishida, Yoji, Kumagai, Takashi, Sato, Seiichi, Ohashi, Kazuteru, Sakamaki, Hisashi, Wakita, Hisashi, Uoshima, Nobuhiko, Nakagawa, Yasunori, Minami, Yosuke, Ogasawara, Masahiro, Takeoka, Tomoharu, Akasaka, Hiroshi, Utsumi, Takahiko, Uike, Naokuni, Sato, Tsutomu, Ando, Sachiko, Usuki, Kensuke, Mizuta, Syuichi, Hashino, Satoshi, Nomura, Tetsuhiko, Shikami, Masato, Fukutani, Hisashi, Ohe, Yokiko, Kosugi, Hiroshi, Shibayama, Hirohiko, Maeda, Yasuhiro, Fukushima, Toshihiro, Yamazaki, Hirohito, Tsubaki, Kazuo, Kukita, Toshimasa, Adachi, Yoko, Nataduka, Toshiki, Sakoda, Hiroto, Yokoyama, Hisayuki, Okamoto, Takahiro, Shirasugi, Yukari, Onishi, Yasushi, Nohgawa, Masaharu, Yoshihara, Satoshi, Morita, Satoshi, Sakamoto, Junichi, and Kimura, Shinya

Published
2018
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