Search

Your search keyword '"Nair, Ajay"' showing total 427 results
Start Over Author "Nair, Ajay"
427 results on '"Nair, Ajay"'

60. Pediatric central nervous system (CNS) neuroblastoma: A case report.

Author

Sharkey, Brandon, Conner, Kaitlin Michelle, McGarvey, Cade R., Nair, Ajay, Dorn, Abbigail, Reinard, Kevin, and Gabel, Brandon

Subjects
MAGNETIC resonance imaging, CENTRAL nervous system, GENETIC regulation, CHILD patients, SOX transcription factors, NEUROBLASTOMA
Abstract

Background: Neuroblastomas are rare tumors activated by the FoxR2 gene commonly found in pediatric patients. Due to the novelty of these tumors, there is no standard diagnostic profile. However, they have been found to express Olig2, MAP2, SOX10, ANKRD55, and synaptophysin, and they can be identified with magnetic resonance imaging (MRI). Treatment with chemotherapy combined with stem cell rescue and craniospinal irradiation can improve non-infant patient outcomes. Case Description: We report a case of a 2-year-old patient who was diagnosed with a neuroblastoma through MRI imaging and pathology that confirmed FoxR2 gene activation. The tumor was successfully removed. However, the tumor was not high-grade like most FoxR2 neuroblastomas. Conclusion: The unusual presentation of a low-grade FoxR2 neuroblastoma demonstrates the necessity to conduct further research into the characteristics of these tumors. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

62. Author Correction: A molecular single-cell lung atlas of lethal COVID-19

Author

Melms, Johannes C., Biermann, Jana, Huang, Huachao, Wang, Yiping, Nair, Ajay, Tagore, Somnath, Katsyv, Igor, Rendeiro, André F., Amin, Amit Dipak, Schapiro, Denis, Frangieh, Chris J., Luoma, Adrienne M., Filliol, Aveline, Fang, Yinshan, Ravichandran, Hiranmayi, Clausi, Mariano G., Alba, George A., Rogava, Meri, Chen, Sean W., Ho, Patricia, Montoro, Daniel T., Kornberg, Adam E., Han, Arnold S., Bakhoum, Mathieu F., Anandasabapathy, Niroshana, Suárez-Fariñas, Mayte, Bakhoum, Samuel F., Bram, Yaron, Borczuk, Alain, Guo, Xinzheng V., Lefkowitch, Jay H., Marboe, Charles, Lagana, Stephen M., Del Portillo, Armando, Tsai, Emily J., Zorn, Emmanuel, Markowitz, Glen S., Schwabe, Robert F., Schwartz, Robert E., Elemento, Olivier, Saqi, Anjali, Hibshoosh, Hanina, Que, Jianwen, and Izar, Benjamin

Published
2021
Full Text
View/download PDF

63. Supplementary Figure 2 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

64. Supplementary Figure 5 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

65. Supplementary Figure 4 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

66. Data from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

67. Supplementary Tables from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

68. Supplementary Figure 1 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

69. Supplementary Figure 3 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

70. Supplementary Figure 6 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

71. Key Resources Tables from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

72. Supplementary Figure 7 from A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Author

Lo, Yuan-Hung, primary, Kolahi, Kevin S., primary, Du, Yuhong, primary, Chang, Chiung-Ying, primary, Krokhotin, Andrey, primary, Nair, Ajay, primary, Sobba, Walter D., primary, Karlsson, Kasper, primary, Jones, Sunny J., primary, Longacre, Teri A., primary, Mah, Amanda T., primary, Tercan, Bahar, primary, Sockell, Alexandra, primary, Xu, Hang, primary, Seoane, Jose A., primary, Chen, Jin, primary, Shmulevich, Ilya, primary, Weissman, Jonathan S., primary, Curtis, Christina, primary, Califano, Andrea, primary, Fu, Haian, primary, Crabtree, Gerald R., primary, and Kuo, Calvin J., primary

Published
2023
Full Text
View/download PDF

73. Supplementary Data from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

Author

Geethadevi, Anjali, primary, Nair, Ajay, primary, Parashar, Deepak, primary, Ku, Zhiqiang, primary, Xiong, Wei, primary, Deng, Hui, primary, Li, Yongsheng, primary, George, Jasmine, primary, McAllister, Donna M., primary, Sun, Yunguang, primary, Kadamberi, Ishaque P., primary, Gupta, Prachi, primary, Dwinell, Michael B., primary, Bradley, William H., primary, Rader, Janet S., primary, Rui, Hallgeir, primary, Schwabe, Robert F., primary, Zhang, Ningyan, primary, Pradeep, Sunila, primary, An, Zhiqiang, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

74. Data from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

Author

Geethadevi, Anjali, primary, Nair, Ajay, primary, Parashar, Deepak, primary, Ku, Zhiqiang, primary, Xiong, Wei, primary, Deng, Hui, primary, Li, Yongsheng, primary, George, Jasmine, primary, McAllister, Donna M., primary, Sun, Yunguang, primary, Kadamberi, Ishaque P., primary, Gupta, Prachi, primary, Dwinell, Michael B., primary, Bradley, William H., primary, Rader, Janet S., primary, Rui, Hallgeir, primary, Schwabe, Robert F., primary, Zhang, Ningyan, primary, Pradeep, Sunila, primary, An, Zhiqiang, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

75. Supplementary Spread Sheet 1 from Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling

Author

Parashar, Deepak, primary, Nair, Bindu, primary, Geethadevi, Anjali, primary, George, Jasmine, primary, Nair, Ajay, primary, Tsaih, Shirng-Wern, primary, Kadamberi, Ishaque P., primary, Gopinadhan Nair, Gopa Kumar, primary, Lu, Yiling, primary, Ramchandran, Ramani, primary, Uyar, Denise S., primary, Rader, Janet S., primary, Ram, Prahlad T., primary, Mills, Gordon B., primary, Pradeep, Sunila, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

76. Supplementary Spread Sheet 2 from Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling

Author

Parashar, Deepak, primary, Nair, Bindu, primary, Geethadevi, Anjali, primary, George, Jasmine, primary, Nair, Ajay, primary, Tsaih, Shirng-Wern, primary, Kadamberi, Ishaque P., primary, Gopinadhan Nair, Gopa Kumar, primary, Lu, Yiling, primary, Ramchandran, Ramani, primary, Uyar, Denise S., primary, Rader, Janet S., primary, Ram, Prahlad T., primary, Mills, Gordon B., primary, Pradeep, Sunila, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

77. Combined Supplementary Materials from Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling

Author

Parashar, Deepak, primary, Nair, Bindu, primary, Geethadevi, Anjali, primary, George, Jasmine, primary, Nair, Ajay, primary, Tsaih, Shirng-Wern, primary, Kadamberi, Ishaque P., primary, Gopinadhan Nair, Gopa Kumar, primary, Lu, Yiling, primary, Ramchandran, Ramani, primary, Uyar, Denise S., primary, Rader, Janet S., primary, Ram, Prahlad T., primary, Mills, Gordon B., primary, Pradeep, Sunila, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

78. Data from Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling

Author

Parashar, Deepak, primary, Nair, Bindu, primary, Geethadevi, Anjali, primary, George, Jasmine, primary, Nair, Ajay, primary, Tsaih, Shirng-Wern, primary, Kadamberi, Ishaque P., primary, Gopinadhan Nair, Gopa Kumar, primary, Lu, Yiling, primary, Ramchandran, Ramani, primary, Uyar, Denise S., primary, Rader, Janet S., primary, Ram, Prahlad T., primary, Mills, Gordon B., primary, Pradeep, Sunila, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

79. Combined Supplementary Data from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

Author

Geethadevi, Anjali, primary, Nair, Ajay, primary, Parashar, Deepak, primary, Ku, Zhiqiang, primary, Xiong, Wei, primary, Deng, Hui, primary, Li, Yongsheng, primary, George, Jasmine, primary, McAllister, Donna M., primary, Sun, Yunguang, primary, Kadamberi, Ishaque P., primary, Gupta, Prachi, primary, Dwinell, Michael B., primary, Bradley, William H., primary, Rader, Janet S., primary, Rui, Hallgeir, primary, Schwabe, Robert F., primary, Zhang, Ningyan, primary, Pradeep, Sunila, primary, An, Zhiqiang, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

80. SupplementaryMethods.docx from Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth

Author

Geethadevi, Anjali, primary, Nair, Ajay, primary, Parashar, Deepak, primary, Ku, Zhiqiang, primary, Xiong, Wei, primary, Deng, Hui, primary, Li, Yongsheng, primary, George, Jasmine, primary, McAllister, Donna M., primary, Sun, Yunguang, primary, Kadamberi, Ishaque P., primary, Gupta, Prachi, primary, Dwinell, Michael B., primary, Bradley, William H., primary, Rader, Janet S., primary, Rui, Hallgeir, primary, Schwabe, Robert F., primary, Zhang, Ningyan, primary, Pradeep, Sunila, primary, An, Zhiqiang, primary, and Chaluvally-Raghavan, Pradeep, primary

Published
2023
Full Text
View/download PDF

83. Significance of Non-edge Priors in Gene Regulatory Network Reconstruction

Author

Nair, Ajay, Chetty, Madhu, Wangikar, Pramod P., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Loo, Chu Kiong, editor, Yap, Keem Siah, editor, Wong, Kok Wai, editor, Teoh, Andrew, editor, and Huang, Kaizhu, editor

Published
2014
Full Text
View/download PDF

86. Self‐supervised learning improves classification of agriculturally important insect pests in plants

Author

Kar, Soumyashree, primary, Nagasubramanian, Koushik, additional, Elango, Dinakaran, additional, Carroll, Matthew E., additional, Abel, Craig A., additional, Nair, Ajay, additional, Mueller, Daren S., additional, O'Neal, Matthew E., additional, Singh, Asheesh K., additional, Sarkar, Soumik, additional, Ganapathysubramanian, Baskar, additional, and Singh, Arti, additional

Published
2023
Full Text
View/download PDF

88. Effect of summer cover crops on cabbage yield, weed suppression, and N mineralization in a low input cropping system

Author

Bilenky, Moriah T., Nair, Ajay, and McDaniel, Marshall D.

Subjects
Global and Planetary Change, Ecology, Horticulture, Management, Monitoring, Policy and Law, Agronomy and Crop Science, Food Science
Abstract

Summer cover crops (SCCs) provide valuable agroecosystem services to growers using spring and autumn vegetable crop rotations. Choosing the right SCCs to maximize agroecosystem services and fit growers' interests is challenging due to the wide array of SCC functions and one benefit may come at the cost of another (i.e., a tradeoff). In particular, fast-growing grasses may produce greater SCC biomass but may immobilize plant-available N needed by the autumn vegetable crop. We conducted a field study in Ames, Iowa US to compare agroecosystem services – weed suppression, autumn cabbage yield, soil nutrients, and net nitrogen (N) mineralization of eight SCC species over 2 years. Cover crop species were grown for an average of 55 days and included: brown top millet (Panicum ramosum L., BTM), buckwheat (Fagopyrum esculentum Moench, “Mancan”, BW), cowpea (Vigna unguiculata (L). Walp., “Iron and Clay”, CP), flax (Linum usitassimum L. “Golden”, GF), mung bean (Vigna radiata (L.) R. Wilczek, MB), sunnhemp (Crotalaria juncea L., SH), sorghum sudangrass (Sorghum bicolor L. Moench x Sorghum sudanense Piper Staph. “Sorgrow BMR Dwarf”, SS), and Teff grass (Eragrostis tef (Zuccagni) “Selam”, TEF), and a no-SCC control (NCC) treatment. The range of mean cover crop biomass was 0.8 (cowpea) to 7.5 (teff grass) Mg ha−1. There was a strong, negative correlation between SCC biomass and weed biomass (R2 = 0.83). Low biomass producing legumes resulted in greater weed biomass, but 34–58% greater cabbage yield in one of two experimental years. Ion exchange membranes (IEMs) were not able to capture differences in total net N mineralization among SCC treatments however, soil inorganic N was greater under legume SCCs at SCC termination. We show there are tradeoffs when choosing SCCs between weed suppression and net N mineralization and that the environmental conditions, i.e., climate, regulate whether these tradeoffs favor greater vegetable crop yields.

Published
2022
Full Text
View/download PDF

92. Amygdala Models

Author

Guntu, Vinay, primary, Feng, Feng, additional, Alturki, Adel, additional, Nair, Ajay, additional, Samarth, Pranit, additional, and Nair, Satish S., additional

Published
2017
Full Text
View/download PDF

93. Differences in brain connectivity of meditators during assessing neurocognition via gamified experimental logic task: A machine learning approach.

Author

Savanth, Ashwini S, PA, Vijaya, Nair, Ajay K, and Kutty, Bindu M

Abstract

Meditation practices increase attention, memory, and self-awareness. The neuroscientific study of meditation has helped gain useful insights into the functional changes in the brain. In this study, we have assessed the performance of meditators with different years of practice while performing an engaging task rather than studying the meditation practice itself. This task helps assess many neural processes simultaneously and represents task performance in presence of multiple audio-visual distractors as in a real-life scenario. The long-term practice of meditation could bring neuroplastic changes in the way cognitive processing is carried out. It could be conscious and effortful in short-term practitioners and relatively unconscious and effortless in long-term practitioners. Our goal is to understand if it is possible to differentiate between long-term and short-term meditators solely based on their cognitive processing. A group of proficient Rajayoga meditators from the Brahma Kumaris were recruited based on their meditation experience—Long-Term Practitioners (n = 12, mean 13,596 h) and Short-Term Practitioners (n = 10, mean 1095 h). A task-based functional Magnetic Resonance Imaging was acquired while the subjects performed the task. Functional Connectivity Analysis was performed to derive the correlation measures to be used as features for classification. Five supervised Machine Learning algorithms Logistic Regression, Support Vector Machine, Decision Tree, Random Forest, and Gradient Boosted Tree were used for classification. Among all the classifiers Gradient Boosted Tree performed the best with an accuracy of 77% when all the four Functional Connectivity Metrics were used. Connectivity in visual areas, cerebellum, left rostral prefrontal cortex, and middle frontal gyrus was found to be higher in long-term meditators. Such a classification demonstrates that long-term meditation practice brings about neuroplastic changes that influence cognitive processing. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

94. Asthma and neuroinflammation

Author

Nair, Ajay and Rosenkranz, Melissa

Subjects
Medical Sciences, Cognition, Neuroinflammation, immune system diseases, FOS: Clinical medicine, Neurosciences, Medicine and Health Sciences, Medical Immunology, Neurodegeneration, Alzheimer's Disease, Asthma, respiratory tract diseases
Abstract

This project aims to understand the effects of asthma on brain health by examining levels of CSF markers of neuroinflammation, neurodegeneration and Alzheimer's Disease pathology. It will also examine the effects of asthma on cognitive performance. This study will use previously acquired CSF data and will use asthma medications as a proxy for asthmatic status.

Published
2022
Full Text
View/download PDF

97. Abstract 984: Dissecting the ecosystem of treatment-naïve melanoma brain metastasis using multi-modal single-cell analysis

Author

Melms, Johannes C., primary, Biermann, Jana, additional, Amin, Amit Dipak, additional, Wang, Yiping, additional, Tagore, Somnath, additional, Andreatta, Massimo, additional, Nair, Ajay, additional, Rogava, Meri, additional, Ho, Patricia, additional, Caprio, Lindsay A., additional, Walsh, Zachary H., additional, Shah, Shivem, additional, Vacarro, Daniel H., additional, Caldwell, Blake, additional, Luoma, Adrienne M., additional, Driver, Joseph, additional, Ingham, Matthew, additional, Rapisuwon, Suthee, additional, Wargo, Jennifer, additional, Slinguff, Craig L., additional, Macosco, Evan Z., additional, Chen, Fei, additional, Carvajal, Richard, additional, Atkins, Michael B., additional, Davies, Michael A., additional, Azizi, Elham, additional, Carmona, Santiago J., additional, Hibshoosh, Hanina, additional, Canoll, Peter D., additional, Bruce, Jeffrey N., additional, Bi, Wenya L., additional, Schwartz, Gary K., additional, and Izar, Benjamin, additional

Published
2022
Full Text
View/download PDF

98. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis

Author

National Research Foundation of Korea, Ministry of Education (South Korea), European Foundation for the Study of Diabetes, Comunidad de Madrid, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, National Institutes of Health (US), National Cancer Institute (US), Garrido, Amanda, Kim, Eunjeong, Teijeiro, Ana, Sánchez Sánchez, Paula, Gallo, Rosa, Nair, Ajay, Matamala Montoya, María, Perna, Cristian, Vicent, Guillermo P., Muñoz, Javier, Campos-Olivas, Ramón, Melms, Johannes C., Izar, Benjamin, Schwabe, Robert F., Djouder, Nabil, National Research Foundation of Korea, Ministry of Education (South Korea), European Foundation for the Study of Diabetes, Comunidad de Madrid, Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, National Institutes of Health (US), National Cancer Institute (US), Garrido, Amanda, Kim, Eunjeong, Teijeiro, Ana, Sánchez Sánchez, Paula, Gallo, Rosa, Nair, Ajay, Matamala Montoya, María, Perna, Cristian, Vicent, Guillermo P., Muñoz, Javier, Campos-Olivas, Ramón, Melms, Johannes C., Izar, Benjamin, Schwabe, Robert F., and Djouder, Nabil

Abstract

[Background & Aims]: Owing to the lack of genetic animal models that adequately recreate key clinical characteristics of cirrhosis, the molecular pathogenesis of cirrhosis has been poorly characterized, and treatments remain limited. Hence, we aimed to better elucidate the pathological mechanisms of cirrhosis using a novel murine model. [Methods]: We report on the first murine genetic model mimicking human cirrhosis induced by hepatocyte-specific elimination of microspherule protein 1 (MCRS1), a member of non-specific lethal (NSL) and INO80 chromatin-modifier complexes. Using this genetic tool with other mouse models, cell culture and human samples, combined with quantitative proteomics, single nuclei/cell RNA sequencing and chromatin immunoprecipitation assays, we investigated mechanisms of cirrhosis. [Results]: MCRS1 loss in mouse hepatocytes modulates the expression of bile acid (BA) transporters – with a pronounced downregulation of Na+-taurocholate cotransporting polypeptide (NTCP) – concentrating BAs in sinusoids and thereby activating hepatic stellate cells (HSCs) via the farnesoid X receptor (FXR), which is predominantly expressed in human and mouse HSCs. Consistently, re-expression of NTCP in mice reduces cirrhosis, and genetic ablation of FXR in HSCs suppresses fibrotic marks in mice and in vitro cell culture. Mechanistically, deletion of a putative SANT domain from MCRS1 evicts histone deacetylase 1 from its histone H3 anchoring sites, increasing histone acetylation of BA transporter genes, modulating their expression and perturbing BA flow. Accordingly, human cirrhosis displays decreased nuclear MCRS1 and NTCP expression. [Conclusions]: Our data reveal a previously unrecognized function of MCRS1 as a critical histone acetylation regulator, maintaining gene expression and liver homeostasis. MCRS1 loss induces acetylation of BA transporter genes, perturbation of BA flow, and consequently, FXR activation in HSCs. This axis represents a central and universal

Published
2022

99. The Strengths and Weaknesses of ISO 9000 in Vocational Education

Author

Bevans-Gonzales, Theresa L. and Nair, Ajay T.

Abstract

ISO 9000 is a set of quality standards that assists an organization to identify, correct and prevent errors, and to promote continual improvement. Educational institutions worldwide are implementing ISO 9000 as they face increasing external pressure to maintain accountability for funding. Similar to other countries, in the United States vocational education providers are implementing ISO 9000. Although ISO has been successful in manufacturing and service industries, the application to education is relatively new and not without its problems. This study used focus group methods to investigate ISO 9000 implementation at nine career and technical centers in Pennsylvania. The findings indicated that there are strengths of ISO 9000 in vocational education such as an improvement in leadership. However, a number of weaknesses of ISO 9000 were also reported, e. g. the time-consuming implementation process. The findings are intended to assist career and technical educators during the implementation of ISO 9000.

Published
2004

100. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Author

Mederacke, Ingmar, primary, Filliol, Aveline, additional, Affo, Silvia, additional, Nair, Ajay, additional, Hernandez, Celine, additional, Sun, Qiuyan, additional, Hamberger, Florian, additional, Brundu, Francesco, additional, Chen, Yu, additional, Ravichandra, Aashreya, additional, Huebener, Peter, additional, Anke, Helena, additional, Shi, Hongxue, additional, Martínez García de la Torre, Raquel A., additional, Smith, James R., additional, Henderson, Neil C., additional, Vondran, Florian W. R., additional, Rothlin, Carla V., additional, Baehre, Heike, additional, Tabas, Ira, additional, Sancho-Bru, Pau, additional, and Schwabe, Robert F., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results