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683 results on '"Nagasaka, Tetsuro"'

70. Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade

Author

Ei Ei Khin, Kikkawa, Fumitaka, Ino, Kazuhiko, Kajiyama, Hiroaki, Suzuki, Takahiro, Shibata, Kiyosumi, Tamakoshi, Koji, Nagasaka, Tetsuro, and Mizutani, Shigehiko

Subjects
Genetic regulation -- Physiological aspects, Carcinoid -- Health aspects, Carcinoid -- Genetic aspects, T cells -- Genetic aspects, Cell proliferation -- Genetic aspects, Adenocarcinoma -- Health aspects, Adenocarcinoma -- Genetic aspects, Immunohistochemistry -- Research, Endometriosis -- Health aspects, Endometriosis -- Genetic aspects, Gene expression -- Physiological aspects, Proteases -- Genetic aspects, Obstetrics -- Research, Health
Abstract

The authors have investigated the localization and expression of dipeptidyl peptidase IV in different grades of endometrial endometrioid adenocarcinomas. Results demonstrate that dipeptidyl peptidase IV is expressed in normal endomertial glandular cells, and that its expression in endometrial adenocarcinoma is down-regulated with increasing grade.

Published
2003

82. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis

Author

Yoshihara, Masato, primary, Kajiyama, Hiroaki, additional, Tamauchi, Satoshi, additional, Iyoshi, Shohei, additional, Yokoi, Akira, additional, Suzuki, Shiro, additional, Kawai, Michiyasu, additional, Nagasaka, Tetsuro, additional, Takahashi, Kunihiko, additional, Matsui, Shigeyuki, additional, and Kikkawa, Fumitaka, additional

Published
2019
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89. Clinicopathologic study of nasal T/NK-cell lymphoma among the Japanese

Author

Nakamura, Shigeo, Katoh, Eriko, Koshikawa, Takashi, Yatabe, Yasushi, Nagasaka, Tetsuro, Ishida, Hiroji, Tokoro, Yoshiro, Koike, Koichi, Kagami, Yoshitoyo, Ogura, Michinori, Kojima, Masaru, Nara, Yoshiharu, Mizoguchi, Yoshikazu, Hara, Kazuo, Kurita, Soji, Seto, Masao, and Suchi, Taizan

Published
1997

91. A proposed staging system for primary gastric lymphoma

Author

Shimodaira, Masaya, Tsukamoto, Yoshihisa, Niwa, Yasumasa, Goto, Hidemi, Hase, Satoshi, Hayakawa, Tetsuo, and Nagasaka, Tetsuro

Subjects
Stomach cancer -- Prognosis, Tumor staging -- Methods, Lymphomas -- Prognosis, Health
Abstract

Background. Although primary gastric lymphoma is the most common extranodal lymphoma, no specific staging system exists. Methods. The authors reviewed 98 cases histologically classified according to the Working Formulation, including low grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Survival rates were calculated by the Kaplan-Meier method according to T, N, and M of the general rules of the International Union Against Cancer TNM system. The definitions of these categories are as follows: T1, tumor invades the lamina propria or submucosa; T2, the muscularis propria; T3, the subserosa; T4, the serosa without invasion of adjacent structures; T5, adjacent structures; No, no regional lymph node metastasis; N1, perigastric lymph nodes within 3 cm of the edge of the primary tumor; N2, perigastric lymph nodes more than 3 cm from the edge of the primary tumor or in lymph nodes along the left gastric, common hepatic, splenic, or celiac arteries; N3, paraaortic and hepatoduodenal lymph nodes and/or other intraabdominal lymph nodes; N4, beyond N3; MO, no distant metastasis; and M1, positive. Results. The overall 5-year survival rate was 83.5%; it was 100% in T1, 82.4% in T2, 84.2% in T3, 52.9% in T4, and 33.3% in T5; 93.9% in N0, 90.5% in N1, 66.2% in N2, and 44.4% in N3/N4; and 86.0% in M0 and 25.0% in M1. Based on these results, the authors proposed a new staging system as follows: Stage I, T1/N0, N1/M0; Stage II, T1/N2/M0, T2, T3/N0, N1, N2/M0; Stage III, T4, T5/any N/M0, any T/N3, N4/M0; and Stage IV, any T/any N/M1. According to this system, the 5-year survival rate significantly decreased as the stage progressed: 100% in Stage I, 88.9% in Stage II, 52.1% in Stage III, and 25.0% in Stage IV. In Stages I and II, survival rates were not significantly different whether chemotherapy was done or not, whereas in Stage III all patients treated with surgery alone died. Conclusions. This staging system is useful for assessing prognosis of and deciding a therapeutic plan for primary gastric lymphoma. Cancer 1994; 73:2709-15.

Published
1994

97. The possible existence of occult metastasis in patients with ovarian clear-cell carcinoma who underwent complete resection without any residual tumours

Author

Kajiyama, Hiroaki, primary, Suzuki, Shiro, additional, Yoshihara, Masato, additional, Nishino, Kimihiro, additional, Yoshikawa, Nobuhisa, additional, Utsumi, Fumi, additional, Niimi, Kaoru, additional, Mizuno, Mika, additional, Kawai, Michiyasu, additional, Oguchi, Hidenori, additional, Mizuno, Kimio, additional, Yamamuro, Osamu, additional, Nagasaka, Tetsuro, additional, Shibata, Kiyosumi, additional, and Kikkawa, Fumitaka, additional

Published
2018
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98. Immunocytochemical Analysis for Differential Diagnosis of Thyroid Lesions Using Liquid-Based Cytology

Author

HASHIMOTO, KATSUNORI, MORIMOTO, AYUMI, KATO, MAKOTO, TOMINAGA, YOSHIHIRO, MAEDA, NAGAKO, TSUZUKI, TOYONORI, YOKOI, TOYOHARU, and NAGASAKA, TETSURO

Subjects
Thyroid, Liquid-based cytology, Diagnostic cytology, Immunocytochemistry
Abstract

Recently, liquid-based cytology (LBC) has been widely applied to various samples in diagnostic cytology and its usefulness has been reported. In this study, we investigated thyroid cytology that applied LBC and immunocytochemistry to achieve more objective diagnosis and greater diagnostic accuracy. This study included 125 cases (57 papillary carcinomas (PCs), 22 follicular tumors, 43 adenomatous goiters and 3 with Basedow’s disease). After preparing the LBC slide, immunocytochemical staining was performed on each slide with six antibodies (HBME-1, cytokeratin 19 (CK19), high molecular weight cytokeratin (34βE12), galectin-3, CD15 and CA 19-9). All antibodies presented immunopositivity frequently in PCs, but only a few or some of them were positive in other cases. These antibodies were considered positive markers for PCs, and the most reliable marker was 34βE12; its sensitivity, specificity and diagnostic accuracy were 82.5%, 100% and 92.0%, respectively. Relations of immunocytochemical profiles against these markers were assessed using panel 34βE12, GAL-3 and CK19. More than or equal to two of these markers showed co-positive in 53 of 57 PCs, and negative for all markers was observed in only one case. In the other (non PC) cases, the former was 0 of 58 and the latter was 40 cases. In this panel, the sensitivity, specificity and diagnostic accuracy were 93.0%, 100% and 96.8%, respectively. All of these values were higher than or equal to single values of 34βE12. We concluded that the panel in this study is useful for more objective and accurate diagnosis of thyroid cytology.

Published
2011

99. Molecular diagnosis of malignant lymphoma : mantle cell lymphoma, anaplastic large cell lymphoma, and marginal zone B-cell lymphoma of malt

Author

Shimoyama, Yoshie, Sakakibaya, Ayako, Kawai, Kumi, Nagasaka, Tetsuro, and Nakamura, Shigeo

Subjects
Genetic alteration, immune system diseases, hemic and lymphatic diseases, Malignant lymphoma, Translocation, Therapy, Prognosis
Abstract

Malignant lymphoma is a heterogeneous category embracing three major types of lymphoid neoplasms: B cell neoplasms, T and NK cell neoplasms, and Hodgkin lymphoma. Within each type, distinct disease entities are defined based on a combination of morphology, immunophenotype, genetic features and clinical syndromes, the emphasis on which represents a new paradigm in the lymphoma classifi cation of the World Health Organization (WHO). These lymphoma entities often have distinctive cytogenetic abnormalities, usually involving translocations that place a potential cellular oncogene under the infl uence of the immunoglobulin in some low-grade B-cell lymphomas. Both pathologists and oncologists are now concerned with better understanding each disease entity and its spectrum of morphology, genetic events, and clinical behaviors. Over the last decade, signifi cant progress has been made in the molecular characterizations of mantle cell lymphoma, anaplastic large cell lymphoma, and marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), which have not only provided insights into the pathogenesis of lymphomas, but also valuable data that could lead to therapies based on their clinical behavior.

Published
2006

100. Glandular Malignant Peripheral Nerve Sheath Tumor

Author

Nagasaka, Tetsuro, Lai, Raymond, Sone, Michihiko, Nakashima, Tsutomu, and Nakashima, Nobuo

Subjects
Peripheral nerve diseases -- Care and treatment, Neurofibromatosis -- Care and treatment
Abstract

* In this report, we describe a highly unusual case of glandular malignant peripheral nerve sheath tumor presenting as a neck mass in a previously healthy 29-year-old man. Grossly, the tumor was found to arise from a swollen peripheral nerve trunk. The tumor was largely composed of spindle cells that demonstrated marked nuclear pleomorphism and numerous abnormal mitotic figures. In addition, histologically malignant glandular structures lined by simple nonciliated columnar cells with goblet cells were found clustered in the center of the tumor. Examination of the swollen peripheral nerve trunk revealed the presence of a plexiform neurofibroma. The spindle cells were positive for S100. The glands were negative for S100 but positive for keratin, epithelial membrane antigen, and neuroendocrine markers (somatostatin, chromogranin, Leu.7, and calcitonin). This patient was subsequently diagnosed as having von Recklinghausen disease and died of tumor metastasis to the lungs 34 months after the presentation. To our knowledge, only 3 similar cases have been previously described in the literature. (Arch Pathol Lab Med. 2000;124:1364-1368), Peripheral nerve sheath tumor (PNST) containing a glandular component, commonly referred to as glandular PNST, represents a rare entity found largely in patients with von Recklinghausen disease. As described in [...]

Published
2000

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