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The intercalation of indomethacin into the interlayer gallery of layered zinc hydroxide (LZH) has been successfully executed using the simple ion exchange approaches. The synthesized intercalation compound, indomethacin-LZH nanohybrid, was characterized using PXRD, FTIR, SEM, BET, and STA. From the PXRD results, the intercalation of indomethacin anions into the interlayer gallery of LZH was successful; showing the formation of a new peak at lower 2θ with a basal spacing of 21.96 Å. FTIR analysis of the nanohybrid further supported the presence of indomethacin in the interlayer of the indomethacin-LZH nanohybrid. STA analysis confirms that the nanohybrid has higher thermal stability than pure indomethacin. The in vitro release mechanism of the indomethacin anions from the indomethacin-LZH nanohybrid showed slow release, with 95% and 78% release in phosphate buffer saline (PBS) solution at pH 4.8 and 7.4, respectively. The release behavior of indomethacin from its intercalation compounds in PBS solution at pH 4.8 and 7.4 follows the Higuchi model. In addition, the nanohybrid treated with normal fibroblast cell line shows that it reduces cell viability in a dose and time-dependent manner. This study shows that the high potential of the nanohybrid as an encapsulated material for the controlled release formulation of nonsteroidal anti-inflammatory (NASID) anions. [ABSTRACT FROM AUTHOR]

New drug delivery systems are very helpful in diagnosis and treatment of diseases through controlled and targeted drug delivery. They can increase bioavailability of drugs and reduce their side effects. Metal-organic frameworks (MOFs) are alternative drug delivery systems, which are suitable for targeted drug delivery due to their adjustable pore sizes and compatibility by adding some functional groups. Application of these compounds permits simultaneous use of several advantages including biocompatibility, the ability to absorb large amounts of drugs and control drug release. The present study was designed to provide Zn2(bdc)2(dabco) MOF and evaluate its performance in absorbing and releasing gentamicin. Characterization methods, such as FTIR, XRD, SEM, BET, UV-Vis spectroscopy and TGA, were employed to characterize the gentamicin-loaded Zn2(bdc)2(dabco) structure. The amount of drug release from Zn2(bdc)2(dabco) was measured in buffer solutions with 7.4 and 5.0 pHs. Furthermore, antibacterial properties of the drug, MOF and drug-loaded MOF have been investigated against Gram-positive and Gram-negative bacteria. This study shows the potential of using Zn2(bdc)2(dabco) frameworks for controlled release of antibiotic drugs. [ABSTRACT FROM AUTHOR]

In the present study, a hydrothermal method was developed to prepare nalidixic acid-loaded [Zn2(bdc)2(dabco)] metal–organic frameworks. The self-assembly of primary building blocks was used for synthesis of [Zn2(bdc)2(dabco)] at room temperature. The zinc metal ion was used as a connector, 1,4-benzenedicarboxylate (bdc) as a chelating ligand, and 1,4-diazabicyclo[2.2.2]octane (dabco) as a bridging ligand. The metal organic frameworks were used as the carriers for drug delivery system, where it could entrap nalidixic acid as a model drug. X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), ultraviolet-visible spectroscopy (UV–vis), BET nitrogen adsorption–desorption method, and scanning electron microscopy (SEM) were used for characterization of samples. The drug release was also monitored, and 96 and 62% of the loaded drug were released over 120 h at pH values of 5.0 and 7.4, respectively. The antimicrobial activities of [Zn2(bdc)2(dabco)] and nalidixic acid-loaded [Zn2(bdc)2(dabco)] were tested against Gram-positive and Gram-negative species. The results revealed that this nanoscale metal organic framework may be regarded as a simple and stable platform for drug release in the treatment of infectious diseases. [ABSTRACT FROM AUTHOR]

Nanoparticles of sulfonamide are prepared by the reaction of a benzenesulfonyl chloride with ammonia or an amine in acetonitrile solvent. The ultrasonic treatment was applied for preparation of nanoparticles. The produced sulfonamide nanoparticles were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), transmission electron microscope (TEM), scanning electron microscope (SEM), and other techniques. The antibacterial activities of sulfonamide nanoparticles derivatives tested against microorganism and compared with bulk forms (non-nano) conditions. The antibacterial activities of synthesized compounds were studied against two Gram-negative bacteria, Escherichia coli, Klebsiella pneumoniae, and two Gram-positive species, Staphylococcus aureus and Bacillus subtilis. These compounds antifungal activities have been studied against, Candida albicans, Aspergillus flavus, Aspergillus nigar. [ABSTRACT FROM PUBLISHER]