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52. The Karachi intracranial stenosis study (KISS) Protocol: An urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan

Author

Asif Rasheed, Fawad Taj, Philippe M. Frossard, Mohammad Wasay, Nadir Ali Syed, Niaz Sheikh, Khalid Mahmood, Farrukh Shahab Khan, Moazzam Zaidi, Muhammad Masroor Ahmed, Muhammed Murtaza, Madiha Yameen, Lajpat Bansari, M Samuel, Fahad Hashmat, Karim Ullah Makki, Shahan Waheed, Sobia Naz, Uzma Saleem, Ayeesha Kamran Kamal, Bhojo A Khealani, Nabi Shah, Danish Saleheen, Naveeduddin Ahmed, Naved Iqbal, Abdul Rauf Memon, Syed Vaqas Alam, and Babar Junaidi

Subjects
Adult, Male, medicine.medical_specialty, Neurology, Clinical Neurology, Constriction, Pathologic, lcsh:RC346-429, Study Protocol, Clinical Protocols, Risk Factors, Medicine, Humans, Neurochemistry, Pakistan, Prospective Studies, cardiovascular diseases, Prospective cohort study, Stroke, lcsh:Neurology. Diseases of the nervous system, Aged, Aged, 80 and over, Cerebral Cortex, business.industry, Case-control study, General Medicine, Cerebral Arteries, Middle Aged, medicine.disease, Transcranial Doppler, Stenosis, Cerebrovascular Disorders, Case-Control Studies, Female, Neurology (clinical), Radiology, Neurosurgery, business
Abstract

Background Intracranial stenosis is the most common cause of stroke among Asians. It has a poor prognosis with a high rate of recurrence. No effective medical or surgical treatment modality has been developed for the treatment of stroke due to intracranial stenosis. We aim to identify risk factors and biomarkers for intracranial stenosis and to develop techniques such as use of transcranial doppler to help diagnose intracranial stenosis in a cost-effective manner. Methods/Design The Karachi Intracranial Stenosis Study (KISS) is a prospective, observational, case-control study to describe the clinical features and determine the risk factors of patients with stroke due to intracranial stenosis and compare them to those with stroke due to other etiologies as well as to unaffected individuals. We plan to recruit 200 patients with stroke due to intracranial stenosis and two control groups each of 150 matched individuals. The first set of controls will include patients with ischemic stroke that is due to other atherosclerotic mechanisms specifically lacunar and cardioembolic strokes. The second group will consist of stroke free individuals. Standardized interviews will be conducted to determine demographic, medical, social, and behavioral variables along with baseline medications. Mandatory procedures for inclusion in the study are clinical confirmation of stroke by a healthcare professional within 72 hours of onset, 12 lead electrocardiogram, and neuroimaging. In addition, lipid profile, serum glucose, creatinine and HbA1C will be measured in all participants. Ancillary tests will include carotid ultrasound, transcranial doppler and magnetic resonance or computed tomography angiogram to rule out concurrent carotid disease. Echocardiogram and other additional investigations will be performed at these centers at the discretion of the regional physicians. Discussion The results of this study will help inform locally relevant clinical guidelines and effective public health and individual interventions.

Published
2009

55. Additional file 1: Table S1. of Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

Author

Shafqat Ahmad, Zhao, Wei, RenstrĂśm, Frida, Rasheed, Asif, Samuel, Maria, Mozzam Zaidi, Nabi Shah, Mallick, Nadeem, Khan Zaman, Ishaq, Mohammad, Rasheed, Syed, Fazal-Ur-Rheman Memon, Hanif, Bashir, Lakhani, Muhammad, Ahmed, Faisal, Shahana Kazmi, Frossard, Philippe, Franks, Paul, and Danish Saleheen

Subjects
3. Good health
Abstract

Quality control descriptive of 95 BMI associated SNPs in the PROMIS Cohort (Nâ =â 16,157). (DOCX 52 kb)

56. Additional file 1: Table S1. of Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

Author

Shafqat Ahmad, Zhao, Wei, RenstrĂśm, Frida, Rasheed, Asif, Samuel, Maria, Mozzam Zaidi, Nabi Shah, Mallick, Nadeem, Khan Zaman, Ishaq, Mohammad, Rasheed, Syed, Fazal-Ur-Rheman Memon, Hanif, Bashir, Lakhani, Muhammad, Ahmed, Faisal, Shahana Kazmi, Frossard, Philippe, Franks, Paul, and Danish Saleheen

Subjects
3. Good health
Abstract

Quality control descriptive of 95 BMI associated SNPs in the PROMIS Cohort (Nâ =â 16,157). (DOCX 52 kb)

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