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51. Assessment of the EarlyCDT‐Lung test as an early biomarker of lung cancer in ever‐smokers: A retrospective nested case‐control study in two prospective cohorts

Author

Wu, Wendy Yi‐Ying, primary, Haider, Zahra, additional, Feng, Xiaoshuang, additional, Heath, Alicia K., additional, Tjønneland, Anne, additional, Agudo, Antonio, additional, Masala, Giovanna, additional, Robbins, Hilary A., additional, Huerta, José‐María, additional, Guevara, Marcela, additional, Schulze, Matthias B., additional, Rodriguez‐Barranco, Miguel, additional, Vineis, Paolo, additional, Tumino, Rosario, additional, Kaaks, Rudolf, additional, Fortner, Renée T., additional, Sieri, Sabina, additional, Panico, Salvatore, additional, Nøst, Therese Haugdahl, additional, Sandanger, Torkjel M., additional, Braaten, Tonje, additional, Johansson, Mattias, additional, Melin, Beatrice, additional, and Johansson, Mikael, additional

Published
2022
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55. Identifying and correcting epigenetics measurements for systematic sources of variation

Author

Perrier, Flavie, Novoloaca, Alexei, Ambatipudi, Srikant, Baglietto, Laura, Ghantous, Akram, Perduca, Vittorio, Barrdahl, Myrto, Harlid, Sophia, Ong, Ken K., Cardona, Alexia, Polidoro, Silvia, Nøst, Therese Haugdahl, Overvad, Kim, Omichessan, Hanane, Dollé, Martijn, Bamia, Christina, Huerta, José Marìa, Vineis, Paolo, Herceg, Zdenko, Romieu, Isabelle, and Ferrari, Pietro

Published
2018
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56. Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking

Author

Petrovic, Dusan, Bodinier, Barbara, Dagnino, S., Whitaker, Matthew, Karimi, Maryam, Campanella, Gianluca, Nøst, Therese Haugdahl, Polidoro, Silvia, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Lund, Eiliv, Dugué, Pierre-Antoine, Giles, Graham G., Severi, Gianluca, Southey, Melissa C., Vineis, Paolo, Stringhini, Silvia, Bochud, Murielle, Sandanger, Torkjel M, Vermeulen, Roel, Guida, Florence, Chadeau-Hyam, Marc, and IRAS OH Epidemiology Chemical Agents

Subjects
DNA methylation, Variable selection, Smoking, Lung cancer, Partial correlation network
Abstract

Smoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of smoking in these associations. We analysed CpGs in relation to lung cancer in participants from two nested case–control studies, using (LASSO)-penalised regression. We accounted for the effects of smoking using known smoking-related CpGs, and through conditional-independence network. We identified 29 CpGs (8 smoking-related, 21 smoking-unrelated) associated with lung cancer. Models additionally adjusted for Comprehensive Smoking Index-(CSI) selected 1 smoking-related and 49 smoking-unrelated CpGs. Selected CpGs yielded excellent discriminatory performances, outperforming information provided by CSI only. Of the 8 selected smoking-related CpGs, two captured lung cancer-relevant effects of smoking that were missed by CSI. Further, the 50 CpGs identified in the CSI-adjusted model complementarily explained lung cancer risk. These markers may provide further insight into lung cancer carcinogenesis and help improving early identification of high-risk patients.

Published
2022

57. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Author

Porta, Miquel, Gasull, M., Pumarega, J., Kiviranta, Hannu, Rantakokko, Panu, Raaschou-Nielsen, Ole, Bergdahl, Ingvar A, Sandanger, Torkjel Manning, Agudo, Antonio, Rylander, Charlotta, Nøst, Therese Haugdahl, Aune, Dagfinn, Heath, A.K., Cirera, Lluis, Goñi-Irigoyen, Fernando, Alguacil, Juan, Gimenez-Robert, Alex, Tjonneland, Anne, Sund, Malin, Overvad, Kim, Mancini, Francesca Romana, Rebours, V., Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Schulze, M.B., Trichopoulou, Antonia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Vermeulen, Roel, Quiros, J.R., Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Chirlaque, Maria Dolores, Ardanaz, Eva, Wareham, Nick J, Key, Timothy, Johansson, Mattias, Murphy, Neil, Ferrari, Pietro, Huybrechts, Inge, Chajes, V., González, Carlos A., Bas Bueno-de-Mesquita, Bas Bueno-de-Mesquita, Gunter, M.J., Weiderpass, Elisabete, Riboli, Elio, Duell, Eric J., Katzke, Verena, Vineis, Paolo, and IRAS OH Epidemiology Chemical Agents

Subjects
biomarkers, environmental health, Pancreatic cancer, persistent organic pollutants, methods
Abstract

Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline. Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk. Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.

Published
2022

58. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

Author

Epi Kanker Team B, Cancer, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, Jakszyn, Paula, Epi Kanker Team B, Cancer, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula

Published
2022

59. Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus

Author

Charles, Dolley, Berg, Vivian, Nøst, Therese Haugdahl, Bergdahl, Ingvar, Huber, Sandra, Ayotte, Pierre, Wilsgaard, Tom, Averina, Maria, Sandanger, Torkjel, Rylander, Charlotta, Charles, Dolley, Berg, Vivian, Nøst, Therese Haugdahl, Bergdahl, Ingvar, Huber, Sandra, Ayotte, Pierre, Wilsgaard, Tom, Averina, Maria, Sandanger, Torkjel, and Rylander, Charlotta

Abstract

Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to a complex network of factors that could impact associations with T2DM. Longitudinal studies on this topic are lacking, and few have assessed prospective and cross-sectional associations between repeated POP measurements and T2DM in the same individuals, which may shed light on causality. Objectives: To compare longitudinal trends in concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in T2DM cases and controls, and to examine prospective and cross-sectional associations between PCBs, OCPs and T2DM at different time-points before and after T2DM diagnosis in cases. Methods: We conducted a longitudinal, nested case-control study (1986–2016) of 116 T2DM cases and 139 controls from the Tromsø Study. All participants had three blood samples collected before T2DM diagnosis in cases, and up to two samples thereafter. We used linear mixed-effect models to assess temporal changes of POPs within and between T2DM cases and controls, and logistic regression models to investigate the associations between different POPs and T2DM at different time-points. Results: PCBs, trans-nonachlor, cis-nonachlor, oxychlordane, cis-heptachlor epoxide, p,p’-DDE, and p,p’-DDT declined more slowly in cases than controls, whereas β-HCH and HCB declined similarly in both groups. Most POPs showed positive associations between both pre- and post-diagnostic concentrations and T2DM, though effect estimates were imprecise. These associations were most consistent for cis-heptachlor epoxide. Discussion: The observed positive associations between certain POPs and T2DM may be becaus

Published
2022
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60. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Author

IRAS OH Epidemiology Chemical Agents, Porta, Miquel, Gasull, M., Pumarega, J., Kiviranta, Hannu, Rantakokko, Panu, Raaschou-Nielsen, Ole, Bergdahl, Ingvar A, Sandanger, Torkjel Manning, Agudo, Antonio, Rylander, Charlotta, Nøst, Therese Haugdahl, Aune, Dagfinn, Heath, A.K., Cirera, Lluis, Goñi-Irigoyen, Fernando, Alguacil, Juan, Gimenez-Robert, Alex, Tjonneland, Anne, Sund, Malin, Overvad, Kim, Mancini, Francesca Romana, Rebours, V., Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Schulze, M.B., Trichopoulou, Antonia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Vermeulen, Roel, Quiros, J.R., Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Chirlaque, Maria Dolores, Ardanaz, Eva, Wareham, Nick J, Key, Timothy, Johansson, Mattias, Murphy, Neil, Ferrari, Pietro, Huybrechts, Inge, Chajes, V., González, Carlos A., Bas Bueno-de-Mesquita, Bas Bueno-de-Mesquita, Gunter, M.J., Weiderpass, Elisabete, Riboli, Elio, Duell, Eric J., Katzke, Verena, Vineis, Paolo, IRAS OH Epidemiology Chemical Agents, Porta, Miquel, Gasull, M., Pumarega, J., Kiviranta, Hannu, Rantakokko, Panu, Raaschou-Nielsen, Ole, Bergdahl, Ingvar A, Sandanger, Torkjel Manning, Agudo, Antonio, Rylander, Charlotta, Nøst, Therese Haugdahl, Aune, Dagfinn, Heath, A.K., Cirera, Lluis, Goñi-Irigoyen, Fernando, Alguacil, Juan, Gimenez-Robert, Alex, Tjonneland, Anne, Sund, Malin, Overvad, Kim, Mancini, Francesca Romana, Rebours, V., Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Schulze, M.B., Trichopoulou, Antonia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Vermeulen, Roel, Quiros, J.R., Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Chirlaque, Maria Dolores, Ardanaz, Eva, Wareham, Nick J, Key, Timothy, Johansson, Mattias, Murphy, Neil, Ferrari, Pietro, Huybrechts, Inge, Chajes, V., González, Carlos A., Bas Bueno-de-Mesquita, Bas Bueno-de-Mesquita, Gunter, M.J., Weiderpass, Elisabete, Riboli, Elio, Duell, Eric J., Katzke, Verena, and Vineis, Paolo

Published
2022

61. Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking

Author

IRAS OH Epidemiology Chemical Agents, Petrovic, Dusan, Bodinier, Barbara, Dagnino, S., Whitaker, Matthew, Karimi, Maryam, Campanella, Gianluca, Nøst, Therese Haugdahl, Polidoro, Silvia, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Lund, Eiliv, Dugué, Pierre-Antoine, Giles, Graham G., Severi, Gianluca, Southey, Melissa C., Vineis, Paolo, Stringhini, Silvia, Bochud, Murielle, Sandanger, Torkjel M, Vermeulen, Roel, Guida, Florence, Chadeau-Hyam, Marc, IRAS OH Epidemiology Chemical Agents, Petrovic, Dusan, Bodinier, Barbara, Dagnino, S., Whitaker, Matthew, Karimi, Maryam, Campanella, Gianluca, Nøst, Therese Haugdahl, Polidoro, Silvia, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Lund, Eiliv, Dugué, Pierre-Antoine, Giles, Graham G., Severi, Gianluca, Southey, Melissa C., Vineis, Paolo, Stringhini, Silvia, Bochud, Murielle, Sandanger, Torkjel M, Vermeulen, Roel, Guida, Florence, and Chadeau-Hyam, Marc

Published
2022

62. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

Author

MS MDL 1, Epi Kanker Team B, Cancer, Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A, Muller, David C, Papadopoulou, Areti, Heath, Alicia K, Critselis, Elena, Gunter, Marc J, Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A, Lopez, David S, Bergmann, Manuela M, Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C, Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W G, Quirós, J Ramón, Severi, Gianluca, Cross, Amanda J, Riboli, Ellio, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, MS MDL 1, Epi Kanker Team B, Cancer, Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A, Muller, David C, Papadopoulou, Areti, Heath, Alicia K, Critselis, Elena, Gunter, Marc J, Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A, Lopez, David S, Bergmann, Manuela M, Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C, Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W G, Quirós, J Ramón, Severi, Gianluca, Cross, Amanda J, Riboli, Ellio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K

Published
2022

63. Assessment of the EarlyCDT‐Lung test as an early biomarker of lung cancer in ever‐smokers: A retrospective nested case‐control study in two prospective cohorts.

Author

Wu, Wendy Yi‐Ying, Haider, Zahra, Feng, Xiaoshuang, Heath, Alicia K., Tjønneland, Anne, Agudo, Antonio, Masala, Giovanna, Robbins, Hilary A., Huerta, José‐María, Guevara, Marcela, Schulze, Matthias B., Rodriguez‐Barranco, Miguel, Vineis, Paolo, Tumino, Rosario, Kaaks, Rudolf, Fortner, Renée T., Sieri, Sabina, Panico, Salvatore, Nøst, Therese Haugdahl, and Sandanger, Torkjel M.

Subjects
LUNG cancer, CASE-control method, PULMONARY nodules, COMPUTED tomography, LONGITUDINAL method, EARLY detection of cancer
Abstract

The EarlyCDT‐Lung test is a blood‐based autoantibody assay intended to identify high‐risk individuals for low‐dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT‐Lung test in ever‐smokers. We conducted a nested case‐control study within two prospective cohorts to evaluate the risk‐discriminatory performance of the EarlyCDT‐Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample <3 years prior to diagnosis. Conditional logistic regression was used to estimate the association between EarlyCDT‐Lung test results and lung cancer risk. Sensitivity and specificity of the EarlyCDT‐Lung test were calculated in all subjects and subgroups based on age, smoking history, lung cancer stage, sample collection time before diagnosis and year of sample collection. The overall lung cancer odds ratios were 0.89 (95% CI: 0.34‐2.30) for a moderate risk EarlyCDT‐Lung test result and 1.09 (95% CI: 0.48‐2.47) for a high‐risk test result compared to no significant test result. The overall sensitivity was 8.4% (95% CI: 4.6‐14) and overall specificity was 92% (95% CI: 87‐96) when considering a high‐risk result as positive. Stratified analysis indicated higher sensitivity (17%, 95% CI: 7.2‐32.1) in subjects with blood drawn up to 1 year prior to diagnosis. In conclusion, our study does not support a role of the EarlyCDT‐Lung test in identifying the high‐risk subjects in ever‐smokers for lung cancer screening in the EPIC and NSHDS cohorts. [ABSTRACT FROM AUTHOR]

Published
2023
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65. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, primary, Ferrari, Pietro, additional, Dossus, Laure, additional, Jenab, Mazda, additional, Johansson, Mattias, additional, Rinaldi, Sabina, additional, Travis, Ruth C., additional, His, Mathilde, additional, Key, Tim J., additional, Schmidt, Julie A., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Rothwell, Joseph A., additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Eichelmann, Fabian, additional, Palli, Domenico, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, Bas, additional, Olsen, Karina Standahl, additional, Sandanger, Torkjel Manning, additional, Nøst, Therese Haugdahl, additional, Quirós, J. Ramón, additional, Bonet, Catalina, additional, Barranco, Miguel Rodríguez, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Sandsveden, Malte, additional, Manjer, Jonas, additional, Vidman, Linda, additional, Rentoft, Matilda, additional, Muller, David, additional, Tsilidis, Kostas, additional, Heath, Alicia K., additional, Keun, Hector, additional, Adamski, Jerzy, additional, Keski-Rahkonen, Pekka, additional, Scalbert, Augustin, additional, Gunter, Marc J., additional, and Viallon, Vivian, additional

Published
2022
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66. Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

Author

PRACTICAL Consortium, Bouras, Emmanouil, Karhunen, Ville, Gill, Dipender, Huang, Jian, Haycock, Philip C, Gunter, Marc J, Johansson, Mattias, Brennan, Paul, Key, Tim, Lewis, Sarah J, Martin, Richard M, Murphy, Neil, Platz, Elizabeth A, Travis, Ruth, Yarmolinsky, James, Zuber, Verena, Martin, Paul, Katsoulis, Michail, Freisling, Heinz, Nøst, Therese Haugdahl, Schulze, Matthias B, Dossus, Laure, Hung, Rayjean J, Amos, Christopher I, Ahola-Olli, Ari, Palaniswamy, Saranya, Männikkö, Minna, Auvinen, Juha, Herzig, Karl-Heinz, Keinänen-Kiukaanniemi, Sirkka, Lehtimäki, Terho, Salomaa, Veikko, Raitakari, Olli, Salmi, Marko, Jalkanen, Sirpa, Jarvelin, Marjo-Riitta, Dehghan, Abbas, Tsilidis, Konstantinos K, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Tampere University, Department of Clinical Chemistry, and Clinical Medicine

Subjects
Male, SUSCEPTIBILITY LOCI, BIOMARKERS, Polymorphism, Single Nucleotide, OVARIAN-CANCER, 03 medical and health sciences, 0302 clinical medicine, MARKERS, Meta-Analysis as Topic, Risk Factors, Mendelian randomization, PROSTATE, INTERLEUKIN-1, Humans, Mendelian randomisation, METAANALYSIS, 030304 developmental biology, Cancer, Ovarian Neoplasms, Inflammation, 0303 health sciences, CHALLENGES, Cytokines/genetics, General Medicine, Mendelian Randomization Analysis, 3. Good health, 3121 General medicine, internal medicine and other clinical medicine, 030220 oncology & carcinogenesis, METASTASIS, Medicine, Cytokines, Female, 3111 Biomedicine, Ovarian Neoplasms/epidemiology, ICEP, LUNG, Research Article, Genome-Wide Association Study
Abstract

Background Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis. Methods Up to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, and the MR assumptions were evaluated in sensitivity and colocalization analyses and a false discovery rate (FDR) correction for multiple comparisons was applied. Corresponding germline GWAS summary data for five cancer outcomes (breast, endometrial, lung, ovarian, and prostate), and their subtypes were selected from the largest cancer-specific GWASs available (cases ranging from 12,906 for endometrial to 133,384 for breast cancer). Results There was evidence of inverse associations of macrophage migration inhibitory factor with breast cancer (OR per SD = 0.88, 95% CI 0.83 to 0.94), interleukin-1 receptor antagonist with endometrial cancer (0.86, 0.80 to 0.93), interleukin-18 with lung cancer (0.87, 0.81 to 0.93), and beta-chemokine-RANTES with ovarian cancer (0.70, 0.57 to 0.85) and positive associations of monokine induced by gamma interferon with endometrial cancer (3.73, 1.86 to 7.47) and cutaneous T-cell attracting chemokine with lung cancer (1.51, 1.22 to 1.87). These associations were similar in sensitivity analyses and supported in colocalization analyses. Conclusions Our study adds to current knowledge on the role of specific inflammatory biomarker pathways in cancer aetiology. Further validation is needed to assess the potential of these cytokines as pharmacological or lifestyle targets for cancer prevention.

Published
2022
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67. Additional file 1 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Abstract

Additional file 1. Supplementary material regarding (i) the definition of cancer cases for HCC, GBC, Adv.PrC and Loc.PrC; (ii) the definition and implementation of the data-shared lasso; (iii) the models used to derive point estimates and confidence intervals from the model selected by the data-shared lasso; and (iv) the univariate analysis conducted for comparison.

Published
2022
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68. Additional file 2 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Abstract

Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations identified by the data-shared lasso with (i) the original model (ii) the extended type-specific model. Figure S6. Results from the univariate analyses. Figure S7. Comparison of the associations identified by the data-shared lasso when working with the 50 features (as in our main analysis) or with the original 117 metabolites. Figure S8. Pearson correlation between the 50 clusters. Figure S9. Pearson correlation between the 19 features related to at least one cancer site in our main analysis. Table S1. list of the 117 metabolites studied in the main analysis, and of the 16 additional metabolites studied when excluding the second colorectal study. Table S2. Robustness of the associations identified in the main analysis when including all the pairs from the prostate cancer study. Table S3. Other associations identified in a large proportion of bootstrap samples when including all the pairs from the prostate cancer study.

Published
2022
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69. Seroprevalence of antibodies against SARS-CoV-2 in the adult population during the pre-vaccination period, Norway, winter 2020/21

Author

Anda, Erik Eik, primary, Braaten, Tonje, additional, Borch, Kristin Benjaminsen, additional, Nøst, Therese Haugdahl, additional, Chen, Sairah L F, additional, Lukic, Marko, additional, Lund, Eiliv, additional, Forland, Frode, additional, Leon, David A, additional, Winje, Brita Askeland, additional, Kran, Anne-Marte Bakken, additional, Kalager, Mette, additional, Johansen, Fridtjof Lund, additional, and Sandanger, Torkjel M, additional

Published
2022
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71. A New Pipeline for the Normalization and Pooling of Metabolomics Data

Author

Viallon, Vivian, primary, His, Mathilde, additional, Rinaldi, Sabina, additional, Breeur, Marie, additional, Gicquiau, Audrey, additional, Hemon, Bertrand, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Rostgaard-Hansen, Agnetha Linn, additional, Rothwell, Joseph A., additional, Lecuyer, Lucie, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Johnson, Theron, additional, Schulze, Matthias B., additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Verschuren, W. M. Monique, additional, Engelfriet, Peter, additional, Onland-Moret, Charlotte, additional, Vermeulen, Roel, additional, Nøst, Therese Haugdahl, additional, Urbarova, Ilona, additional, Zamora-Ros, Raul, additional, Rodriguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Huerta, José Maria, additional, Ardanaz, Eva, additional, Melander, Olle, additional, Ottoson, Filip, additional, Vidman, Linda, additional, Rentoft, Matilda, additional, Schmidt, Julie A., additional, Travis, Ruth C., additional, Weiderpass, Elisabete, additional, Johansson, Mattias, additional, Dossus, Laure, additional, Jenab, Mazda, additional, Gunter, Marc J., additional, Lorenzo Bermejo, Justo, additional, Scherer, Dominique, additional, Salek, Reza M., additional, Keski-Rahkonen, Pekka, additional, and Ferrari, Pietro, additional

Published
2021
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72. 588Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Author

Porta, Miquel, primary, Gasull, Magda, additional, Pumarega, José, additional, Kiviranta, Hannu, additional, Rantakokko, Panu, additional, Raaschou-Nielsen, Ole, additional, Bergdahl, Ingvar, additional, Sandanger, Torkjel Manning, additional, Rylander, Charlotta, additional, Nøst, Therese Haugdahl, additional, Duell, Eric, additional, Katzke, Verena, additional, Gunter, Marc, additional, and Vineis, Paolo, additional

Published
2021
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74. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Author

Porta, Miquel, primary, Gasull, Magda, additional, Pumarega, José, additional, Kiviranta, Hannu, additional, Rantakokko, Panu, additional, Raaschou-Nielsen, Ole, additional, Bergdahl, Ingvar A, additional, Sandanger, Torkjel Manning, additional, Agudo, Antoni, additional, Rylander, Charlotta, additional, Nøst, Therese Haugdahl, additional, Donat-Vargas, Carolina, additional, Aune, Dagfinn, additional, Heath, Alicia K, additional, Cirera, Lluís, additional, Goñi-Irigoyen, Fernando, additional, Alguacil, Juan, additional, Giménez-Robert, Àlex, additional, Tjønneland, Anne, additional, Sund, Malin, additional, Overvad, Kim, additional, Mancini, Francesca Romana, additional, Rebours, Vinciane, additional, Boutron-Ruault, Marie-Christine, additional, Kaaks, Rudolf, additional, Schulze, Matthias B, additional, Trichopoulou, Antonia, additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Panico, Salvatore, additional, Vermeulen, Roel, additional, Quirós, J Ramón, additional, Rodríguez-Barranco, Miguel, additional, Colorado-Yohar, Sandra M, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Wareham, Nick, additional, Key, Tim, additional, Johansson, Mattias, additional, Murphy, Neil, additional, Ferrari, Pietro, additional, Huybrechts, Inge, additional, Chajes, Veronique, additional, Gonzalez, Carlos Alberto, additional, Bueno-de-Mesquita, Bas, additional, Gunter, Marc, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Duell, Eric J, additional, Katzke, Verena, additional, and Vineis, Paolo, additional

Published
2021
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75. Prospective identification of elevated circulating CDCP1 in patients years before onset of lung cancer

Author

Dagnino, Sonia, Bodinier, Barbara, Guida, Florence, Smith-Byrne, Karl, Petrovic, Dusan, Whitaker, Matthew D., Nøst, Therese Haugdahl, Agnoli, Claudia, Palli, Domenico, Sacerdote, Carlotta, Panico, Salvatore, Tumino, Rosario, Schulze, Matthias B., Johansson, Mikael, Keski-Rahkonen, Pekka, Scalbert, Augustin, Vineis, Paolo, Johansson, Mattias, Sandanger, Torkjel M., Vermeulen, Roel C.H., Chadeau-Hyam, Marc, Dagnino, Sonia, Bodinier, Barbara, Guida, Florence, Smith-Byrne, Karl, Petrovic, Dusan, Whitaker, Matthew D., Nøst, Therese Haugdahl, Agnoli, Claudia, Palli, Domenico, Sacerdote, Carlotta, Panico, Salvatore, Tumino, Rosario, Schulze, Matthias B., Johansson, Mikael, Keski-Rahkonen, Pekka, Scalbert, Augustin, Vineis, Paolo, Johansson, Mattias, Sandanger, Torkjel M., Vermeulen, Roel C.H., and Chadeau-Hyam, Marc

Abstract

Increasing evidence points to a role for inflammation in lung carcinogenesis. A small number of circulating inflammatory proteins have been identified as showing elevated levels prior to lung cancer diagnosis, indicating the potential for prospective circulating protein concentration as a marker of early carcinogenesis. To identify novel markers of lung cancer risk, we measured a panel of 92 circulating inflammatory proteins in 648 prediagnostic blood samples from two prospective cohorts in Italy and Norway (women only). To preserve the comparability of results and protect against confounding factors, the main statistical analyses were conducted in women from both studies, with replication sought in men (Italian participants). Univariate and penalized regression models revealed for the first time higher blood levels of CDCP1 protein in cases that went on to develop lung cancer compared with controls, irrespective of time to diagnosis, smoking habits, and gender. This association was validated in an additional 450 samples. Associations were stronger for future cases of adenocarcinoma where CDCP1 showed better explanatory performance. Integrative analyses combining gene expression and protein levels of CDCP1 measured in the same individuals suggested a link between CDCP1 and the expression of transcripts of LRRN3 and SEM1. Enrichment analyses indicated a potential role for CDCP1 in pathways related to cell adhesion and mobility, such as the WNT/β-catenin pathway. Overall, this study identifies lung cancer–related dysregulation of CDCP1 expression years before diagnosis.

Published
2021
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76. A new pipeline for the normalization and pooling of metabolomics data

Author

Viallon, Vivian, His, Mathilde, Rinaldi, Sabina, Breeur, Marie, Gicquiau, Audrey, Hemon, Bertrand, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Rothwell, Joseph A., Lecuyer, Lucie, Severi, Gianluca, Kaaks, Rudolf, Johnson, Theron, Schulze, Matthias B., Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Monique Verschuren, W.M., Engelfriet, Peter, Onland-Moret, Charlotte, Vermeulen, Roel, Nøst, Therese Haugdahl, Urbarova, Ilona, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, José Maria, Ardanaz, Eva, Melander, Olle, Ottoson, Filip, Vidman, Linda, Rentoft, Matilda, Schmidt, Julie A., Travis, Ruth C., Weiderpass, Elisabete, Johansson, Mattias, Dossus, Laure, Jenab, Mazda, Gunter, Marc J., Bermejo, Justo Lorenzo, Scherer, Dominique, Salek, Reza M., Keski-Rahkonen, Pekka, Ferrari, Pietro, Viallon, Vivian, His, Mathilde, Rinaldi, Sabina, Breeur, Marie, Gicquiau, Audrey, Hemon, Bertrand, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Rothwell, Joseph A., Lecuyer, Lucie, Severi, Gianluca, Kaaks, Rudolf, Johnson, Theron, Schulze, Matthias B., Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Monique Verschuren, W.M., Engelfriet, Peter, Onland-Moret, Charlotte, Vermeulen, Roel, Nøst, Therese Haugdahl, Urbarova, Ilona, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, José Maria, Ardanaz, Eva, Melander, Olle, Ottoson, Filip, Vidman, Linda, Rentoft, Matilda, Schmidt, Julie A., Travis, Ruth C., Weiderpass, Elisabete, Johansson, Mattias, Dossus, Laure, Jenab, Mazda, Gunter, Marc J., Bermejo, Justo Lorenzo, Scherer, Dominique, Salek, Reza M., Keski-Rahkonen, Pekka, and Ferrari, Pietro

Abstract

Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, treated, and stored according to different protocols, and assayed in different laboratories using different instruments. To address these issues, a new pipeline was developed to normalize and pool metabolomics data through a set of sequential steps: (i) exclusions of the least informative observations and metabolites and removal of outliers; imputation of missing data; (ii) identification of the main sources of variability through principal component partial R-square (PC-PR2) analysis; (iii) application of linear mixed models to remove unwanted variability, including samples’ originating study and batch, and preserve biological variations while accounting for potential differences in the residual variances across studies. This pipeline was applied to targeted metabolomics data acquired using Biocrates AbsoluteIDQ kits in eight case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Comprehensive examination of metabolomics measurements indicated that the pipeline improved the comparability of data across the studies. Our pipeline can be adapted to normalize other molecular data, including biomarkers as well as proteomics data, and could be used for pooling molecular datasets, for example in international consortia, to limit biases introduced by inter-study variability. This versatility of the pipeline makes our work of potential interest to molecular epidemiologists., (This article belongs to the Special Issue Metabolomics Meets Epidemiology).

Published
2021
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77. Reproducible Data Management and Analysis using R

Author

Fjukstad, Bjørn, Shvetsov, Nikita, Nøst, Therese Haugdahl, Bøvelstad, Hege Marie, Halbach, Till, Holsbø, Einar, Hansen, Knut, and Bongo, Lars Ailo

Abstract

Standardizing and documenting computational analyses is necessary to ensure reproducible results. We describe an R-based implementation of data management and preprocessing that is well integrated with the analysis tools typically used for statistical analysis of omics data. We have used these tools to organize data storage and documentation, and to standardize the analysis of gene expression data, in the Norwegian Women and Cancer study.

Published
2020

78. Soil pollution at a major West African E-waste recycling site:Contamination pathways and implications for potential mitigation strategies

Author

Moeckel, Claudia, Breivik, Knut, Nøst, Therese Haugdahl, Sankoh, Alhaji, Jones, Kevin C., Sweetman, Andrew, Moeckel, Claudia, Breivik, Knut, Nøst, Therese Haugdahl, Sankoh, Alhaji, Jones, Kevin C., and Sweetman, Andrew

Abstract

Organic contaminants (polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and chlorinated paraffins (CPs)) and heavy metals and metalloids (Ag, Cd, Co, Cr, Cu, Hg, Ni, Pb, Sb, Zn) were analysed in surface soil samples from the Agbogbloshie e-waste processing and dumping site in Accra (Ghana). In order to identify which of the pollutants are likely to be linked specifically to handling of e-waste, samples were also collected from the Kingtom general waste site in Freetown (Sierra Leone). The results were compared using principal component analyses (PCA). PBDE congeners found in technical octa-BDE mixtures, highly chlorinated PCBs and several heavy metals (Cu, Pb, Ni, Cd, Ag and Hg) showed elevated concentrations in the soils that are likely due to contamination by e-waste. PCAs associated those compounds with pyrogenic PAHs, suggesting that burning of e-waste, a common practice to isolate valuable metals, may cause this contamination. Moreover, other contamination pathways, especially incorporation of waste fragments into the soil, also appeared to play an important role in determining concentrations of some of the pollutants in the soil. Concentrations of several of these compounds were extremely high (especially PBDEs, heavy metals and SCCPs) and in some cases exceeded action guideline levels for soil. This indicates that exposure to these contaminants via the soil alone is potentially harmful to the recyclers and their families living on waste sites. Many organic contaminants and other exposure pathways such as inhalation are not yet included in such guidelines but may also be significant, given that deposition from the air following waste burning was identified as a major pollutant source.

Published
2020

79. Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author

MS MDL 1, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Kliemann, Nathalie, Murphy, Neil, Viallon, Vivian, Freisling, Heinz, Tsilidis, Konstantinos K, Rinaldi, Sabina, Mancini, Francesca Romana, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Boeing, Heiner, Schulze, Matthias B, Masala, Giovanna, Krogh, Vittorio, Sacerdote, Carlotta, Santucci de Magistris, Maria, Bueno-de-Mesquita, Bas, Weiderpass, Elisabete, Kühn, Tilman, Kaaks, Rudolf, Jakszyn, Paula, Redondo-Sánchez, Daniel, Amiano, Pilar, Chirlaque, Maria-Dolores, Barricarte Gurrea, Aurelio, Ericson, Ulrica, Drake, Isabel, Nøst, Therese Haugdahl, Aune, Dagfinn, May, Anne M, Tjønneland, Anne, Dahm, Christina Catherine, Overvad, Kim, Tumino, Rosario, Ramón Quirós, Jose, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Nilsson, Lena Maria, Riboli, Elio, Huybrechts, Inge, Gunter, Marc J, MS MDL 1, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Kliemann, Nathalie, Murphy, Neil, Viallon, Vivian, Freisling, Heinz, Tsilidis, Konstantinos K, Rinaldi, Sabina, Mancini, Francesca Romana, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Boeing, Heiner, Schulze, Matthias B, Masala, Giovanna, Krogh, Vittorio, Sacerdote, Carlotta, Santucci de Magistris, Maria, Bueno-de-Mesquita, Bas, Weiderpass, Elisabete, Kühn, Tilman, Kaaks, Rudolf, Jakszyn, Paula, Redondo-Sánchez, Daniel, Amiano, Pilar, Chirlaque, Maria-Dolores, Barricarte Gurrea, Aurelio, Ericson, Ulrica, Drake, Isabel, Nøst, Therese Haugdahl, Aune, Dagfinn, May, Anne M, Tjønneland, Anne, Dahm, Christina Catherine, Overvad, Kim, Tumino, Rosario, Ramón Quirós, Jose, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Nilsson, Lena Maria, Riboli, Elio, Huybrechts, Inge, and Gunter, Marc J

Published
2020

80. Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT study

Author

Sun, Yi-Qian, primary, Richmond, Rebecca C, additional, Suderman, Matthew, additional, Min, Josine L, additional, Battram, Thomas, additional, Flatberg, Arnar, additional, Beisvag, Vidar, additional, Nøst, Therese Haugdahl, additional, Guida, Florence, additional, Jiang, Lin, additional, Wahl, Sissel Gyrid Freim, additional, Langhammer, Arnulf, additional, Skorpen, Frank, additional, Walker, Rosie M, additional, Bretherick, Andrew D, additional, Zeng, Yanni, additional, Chen, Yue, additional, Johansson, Mattias, additional, Sandanger, Torkjel M, additional, Relton, Caroline L, additional, and Mai, Xiao-Mei, additional

Published
2021
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83. Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Public Health Practice, MS MDL 1, Epi Methoden Team 3, Cancer, JC onderzoeksprogramma Kanker, Ward, Heather A., Whitman, Julia, Muller, David C., Johansson, Mattias, Jakszyn, Paula, Weiderpass, Elisabete, Palli, Domenico, Fanidi, Anouar, Vermeulen, Roel, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C., Overvad, Kim, Severi, Gianluca, Boutron-Ruault, Marie Christine, Affret, Aurélie, Kaaks, Rudolf, Fortner, Renee, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kotanidou, Anastasia, Berrino, Franco, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Quirós, Jose Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, Jose Maria, Ardanaz, Eva, Drake, Isabel, Brunnström, Hans, Johansson, Mikael, Grankvist, Kjell, Travis, Ruth C., Freisling, Heinz, Stepien, Magdalena, Merritt, Melissa A., Riboli, Elio, Cross, Amanda J., Public Health Practice, MS MDL 1, Epi Methoden Team 3, Cancer, JC onderzoeksprogramma Kanker, Ward, Heather A., Whitman, Julia, Muller, David C., Johansson, Mattias, Jakszyn, Paula, Weiderpass, Elisabete, Palli, Domenico, Fanidi, Anouar, Vermeulen, Roel, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C., Overvad, Kim, Severi, Gianluca, Boutron-Ruault, Marie Christine, Affret, Aurélie, Kaaks, Rudolf, Fortner, Renee, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kotanidou, Anastasia, Berrino, Franco, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Quirós, Jose Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, Jose Maria, Ardanaz, Eva, Drake, Isabel, Brunnström, Hans, Johansson, Mikael, Grankvist, Kjell, Travis, Ruth C., Freisling, Heinz, Stepien, Magdalena, Merritt, Melissa A., Riboli, Elio, and Cross, Amanda J.

Published
2019

85. Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Harms, Laura M., primary, Scalbert, Augustin, additional, Zamora-Ros, Raul, additional, Rinaldi, Sabina, additional, Jenab, Mazda, additional, Murphy, Neil, additional, Achaintre, David, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Romana Mancini, Francesca, additional, Mahamat-Saleh, Yahya, additional, Boutron-Ruault, Marie-Christine, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Trichopoulou, Antonia, additional, Martimianaki, Georgia, additional, Karakatsani, Anna, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel C. H., additional, Weiderpass, Elisabete, additional, Nøst, Therese Haugdahl, additional, Lasheras, Cristina, additional, Rodríguez-Barranco, Miguel, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Dorronsoro, Miren, additional, Hultdin, Johan, additional, Schmidt, Julie A., additional, Gunter, Marc, additional, Riboli, Elio, additional, and Aleksandrova, Krasimira, additional

Published
2019
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86. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status

Author

Fedirko, Veronika, primary, Jenab, Mazda, additional, Méplan, Catherine, additional, Jones, Jeb S., additional, Zhu, Wanzhe, additional, Schomburg, Lutz, additional, Siddiq, Afshan, additional, Hybsier, Sandra, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Omichessan, Hanane, additional, Perduca, Vittorio, additional, Boutron-Ruault, Marie-Christine, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Aleksandrova, Krasimira, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Kotanidou, Anastasia, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Naccarati, Alessio, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel C.H., additional, Weiderpass, Elisabete, additional, Skeie, Guri, additional, Nøst, Therese Haugdahl, additional, Lujan-Barroso, Leila, additional, Quirós, J. Ramón, additional, Huerta, José María, additional, Rodríguez-Barranco, Miguel, additional, Barricarte, Aurelio, additional, Gylling, Björn, additional, Harlid, Sophia, additional, Bradbury, Kathryn E., additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Gunter, Marc, additional, Murphy, Neil, additional, Freisling, Heinz, additional, Tsilidis, Kostas, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, Hesketh, John E., additional, and Hughes, David J., additional

Published
2019
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88. Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Ward, Heather A., Whitman, Julia, Muller, David C., Johansson, Mattias, Jakszyn, Paula, Weiderpass, Elisabete, Palli, Domenico, Fanidi, Anouar, Vermeulen, Roel, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C., Overvad, Kim, Severi, Gianluca, Boutron-Ruault, Marie Christine, Affret, Aurélie, Kaaks, Rudolf, Fortner, Renee, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kotanidou, Anastasia, Berrino, Franco, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Quirós, Jose Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, Jose Maria, Ardanaz, Eva, Drake, Isabel, Brunnström, Hans, Johansson, Mikael, Grankvist, Kjell, Travis, Ruth C., Freisling, Heinz, Stepien, Magdalena, Merritt, Melissa A., Riboli, Elio, Cross, Amanda J., Ward, Heather A., Whitman, Julia, Muller, David C., Johansson, Mattias, Jakszyn, Paula, Weiderpass, Elisabete, Palli, Domenico, Fanidi, Anouar, Vermeulen, Roel, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C., Overvad, Kim, Severi, Gianluca, Boutron-Ruault, Marie Christine, Affret, Aurélie, Kaaks, Rudolf, Fortner, Renee, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kotanidou, Anastasia, Berrino, Franco, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Quirós, Jose Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, Jose Maria, Ardanaz, Eva, Drake, Isabel, Brunnström, Hans, Johansson, Mikael, Grankvist, Kjell, Travis, Ruth C., Freisling, Heinz, Stepien, Magdalena, Merritt, Melissa A., Riboli, Elio, and Cross, Amanda J.

Abstract

BACKGROUND: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding. METHODS: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 countries completed demographic and dietary questionnaires at recruitment. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident lung cancer (n = 3731) risk relative to haem iron, non-haem iron, and total dietary iron intake. A corresponding analysis was conducted among a nested subset of 800 lung cancer cases and 1489 matched controls for whom serum cotinine was available. RESULTS: Haem iron was associated with lung cancer risk, including after adjustment for details of smoking history (time since quitting, number of cigarettes per day): as a continuous variable (HR per 0.3 mg/1000 kcal 1.03, 95% CI 1.00-1.07), and in the highest versus lowest quintile (HR 1.16, 95% CI 1.02-1.32; trend across quintiles: P = 0.035). In contrast, non-haem iron intake was related inversely with lung cancer risk; however, this association attenuated after adjustment for smoking history. Additional adjustment for serum cotinine did not considerably alter the associations detected in the nested case-control subset. CONCLUSIONS: Greater haem iron intake may be modestly associated with lung cancer risk.

Published
2018

89. Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

One Health Chemisch, dIRAS RA-2, Ward, Heather A., Whitman, Julia, Muller, David C., Johansson, Mattias, Jakszyn, Paula, Weiderpass, Elisabete, Palli, Domenico, Fanidi, Anouar, Vermeulen, Roel, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C., Overvad, Kim, Severi, Gianluca, Boutron-Ruault, Marie Christine, Affret, Aurélie, Kaaks, Rudolf, Fortner, Renee, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kotanidou, Anastasia, Berrino, Franco, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Quirós, Jose Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, Jose Maria, Ardanaz, Eva, Drake, Isabel, Brunnström, Hans, Johansson, Mikael, Grankvist, Kjell, Travis, Ruth C., Freisling, Heinz, Stepien, Magdalena, Merritt, Melissa A., Riboli, Elio, Cross, Amanda J., One Health Chemisch, dIRAS RA-2, Ward, Heather A., Whitman, Julia, Muller, David C., Johansson, Mattias, Jakszyn, Paula, Weiderpass, Elisabete, Palli, Domenico, Fanidi, Anouar, Vermeulen, Roel, Tjønneland, Anne, Hansen, Louise, Dahm, Christina C., Overvad, Kim, Severi, Gianluca, Boutron-Ruault, Marie Christine, Affret, Aurélie, Kaaks, Rudolf, Fortner, Renee, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kotanidou, Anastasia, Berrino, Franco, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Quirós, Jose Ramón, Agudo, Antonio, Rodríguez-Barranco, Miguel, Larrañaga, Nerea, Huerta, Jose Maria, Ardanaz, Eva, Drake, Isabel, Brunnström, Hans, Johansson, Mikael, Grankvist, Kjell, Travis, Ruth C., Freisling, Heinz, Stepien, Magdalena, Merritt, Melissa A., Riboli, Elio, and Cross, Amanda J.

Published
2018

90. DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort

Author

One Health Chemisch, dIRAS RA-2, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Guida, Florence, Rylander, Charlotta, Campanella, Gianluca, Muller, David C, van Dongen, Jenny, Boomsma, Dorret I, Johansson, Mattias, Vineis, Paolo, Vermeulen, Roel, Lund, Eiliv, Chadeau-Hyam, Marc, One Health Chemisch, dIRAS RA-2, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Guida, Florence, Rylander, Charlotta, Campanella, Gianluca, Muller, David C, van Dongen, Jenny, Boomsma, Dorret I, Johansson, Mattias, Vineis, Paolo, Vermeulen, Roel, Lund, Eiliv, and Chadeau-Hyam, Marc

Published
2018

91. Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Ward, Heather A., primary, Whitman, Julia, additional, Muller, David C., additional, Johansson, Mattias, additional, Jakszyn, Paula, additional, Weiderpass, Elisabete, additional, Palli, Domenico, additional, Fanidi, Anouar, additional, Vermeulen, Roel, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Dahm, Christina C., additional, Overvad, Kim, additional, Severi, Gianluca, additional, Boutron-Ruault, Marie-Christine, additional, Affret, Aurélie, additional, Kaaks, Rudolf, additional, Fortner, Renee, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, La Vecchia, Carlo, additional, Kotanidou, Anastasia, additional, Berrino, Franco, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H., additional, Nøst, Therese Haugdahl, additional, Sandanger, Torkjel M., additional, Quirós, Jose Ramón, additional, Agudo, Antonio, additional, Rodríguez-Barranco, Miguel, additional, Larrañaga, Nerea, additional, Huerta, Jose Maria, additional, Ardanaz, Eva, additional, Drake, Isabel, additional, Brunnström, Hans, additional, Johansson, Mikael, additional, Grankvist, Kjell, additional, Travis, Ruth C., additional, Freisling, Heinz, additional, Stepien, Magdalena, additional, Merritt, Melissa A., additional, Riboli, Elio, additional, and Cross, Amanda J., additional

Published
2018
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94. Understanding temporality in human concentrations of organic contaminants -Considering human concentrations over time and through life in perspective of historic production and use

Author

Nøst, Therese Haugdahl and Odland, Jon Øyvind

Subjects
DOKTOR-003, VDP::Medical disciplines: 700::Health sciences: 800::Other health science disciplines: 829, VDP::Medisinske Fag: 700::Helsefag: 800::Andre helsefag: 829, The Tromsø Study, Tromsøundersøkelsen
Abstract

Paper II of this thesis is not available in Munin.Repeated measurements of per‐ and polyfluoroalkyl substances (PFASs) from 1979 to 2007 in males from Northern Norway: Assessing time trends, compound correlations and relations to age/birth cohort. Nøst, TH, Vestergren, R, Berg, V, Nieboer, E, Odland, JØ, Sandanger, TM.Available in Environment International, 2014, vol. 67 Modern human lifestyle depends on a great number of synthetic chemicals and many designated as persistent organic pollutants (POPs). There are concerns for harmful health effects of POPs even for the background exposure experienced by the general population and especially for foetuses and children. The overarching aim of this thesis was to enhance our understanding of how human concentrations of POPs have changed in individuals over time. Five repeated measurements from 54 men in the Tromsø Study, Northern Norway provided longitudinal serum data from 1979 to 2007 for polychlorinated biphenyls (PCBs), organochlorine pesticides and per- and polyfluoroalkyl substances (PFASs). Concentrations of most PCBs and pesticides decreased from 1979 or 1986 and likely reflect the decreasing concentrations in the environment during the same period. Concentrations increased for some PFASs from 1979 until 2001 when major productions were phased out and decreased to 2007. For other PFASs, concentrations increased during the entire study period. Many of the compounds measured were banned before or during the study period and the time trends of POP concentrations display a strong link to production and use of these compounds. These time trends clearly show that initiatives to stop production and use of POPs have led to decreasing concentrations of the same POPs in humans. Measured concentrations of PCBs were compared with concentrations predicted by emission-based mechanistic exposure modelling. The model simulations for PCB concentrations demonstrated reliable performance to reproduce median measured concentrations of PCBs in the Northern Norwegian men. Person-specific predictions were obtained for pregnant and postmenopausal women and they were in agreement with measurements. Predicted concentrations from birth until blood sampling for the study subjects demonstrated large differences between individuals in peak concentrations and temporal changes. Also, these results demonstrate the potential of mechanistic models as useful tools in human biomonitoring and effect studies.

Published
2014

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