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53. Handheld cellular telephones and risk of acoustic neuroma

Author

Muscat, J. E., Malkin, M. G., Shore, R. E., Thompson, S., Neugut, Alfred I., Stellman, Steven D., and Bruce, J.

Subjects
Epidemiology
Abstract

The hypothesis that intracranial energy deposition from handheld cellular telephones causes acoustic neuroma was tested in an epidemiologic study of 90 patients and 86 control subjects. The relative risk was 0.9 (p _ 0.07) and did not vary significantly by the frequency, duration, and lifetime hours of use. In patients who used cellular telephones, the tumor occurred more often on the contralateral than ipsilateral side of the head. Further efforts should focus on potentially longer induction periods.

Published
2002
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54. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, Af, Winn, Dm, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, M, Vaughan, Tl, Lazarus, P, Purdue, Mp, Hayes, Rb, Chen, C, Schwartz, Sm, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, G, Schantz, S, Simonato, L, Brenner, H, Conway, Di, Macfarlane, Tv, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, S, Lee, Ya, Hashibe, M, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Boccia, Stefania (ORCID:0000-0002-1864-749X), Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, Af, Winn, Dm, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, M, Vaughan, Tl, Lazarus, P, Purdue, Mp, Hayes, Rb, Chen, C, Schwartz, Sm, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, G, Schantz, S, Simonato, L, Brenner, H, Conway, Di, Macfarlane, Tv, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, S, Lee, Ya, Hashibe, M, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Published
2013

55. Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Wyss, A, Hashibe, M, Chuang, S, Lee, Ya, Zhang, Z, Yu, G, Winn, Dm, Wei, Q, Talamini, R, Szeszenia Dabrowska, N, Sturgis, Em, Smith, E, Shangina, O, Schwartz, Sm, Schantz, S, Rudnai, P, Purdue, Mp, Eluf Neto, J, Muscat, J, Morgenstern, H, Michaluart, P, Menezes, A, Matos, E, Mates, In, Lissowska, J, Levi, F, Lazarus, P, La Vecchia, C, Koifman, S, Herrero, R, Hayes, Rb, Franceschi, S, Wunsch Filho, V, Fernandez, L, Fabianova, E, Daudt, Aw, Dal Maso, L, Curado, Mp, Chen, C, Castellsague, X, De Carvalho, Mb, Cadoni, Gabriella, Boccia, Stefania, Brennan, P, Boffetta, P, Olshan, Af, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Wyss, A, Hashibe, M, Chuang, S, Lee, Ya, Zhang, Z, Yu, G, Winn, Dm, Wei, Q, Talamini, R, Szeszenia Dabrowska, N, Sturgis, Em, Smith, E, Shangina, O, Schwartz, Sm, Schantz, S, Rudnai, P, Purdue, Mp, Eluf Neto, J, Muscat, J, Morgenstern, H, Michaluart, P, Menezes, A, Matos, E, Mates, In, Lissowska, J, Levi, F, Lazarus, P, La Vecchia, C, Koifman, S, Herrero, R, Hayes, Rb, Franceschi, S, Wunsch Filho, V, Fernandez, L, Fabianova, E, Daudt, Aw, Dal Maso, L, Curado, Mp, Chen, C, Castellsague, X, De Carvalho, Mb, Cadoni, Gabriella, Boccia, Stefania, Brennan, P, Boffetta, P, Olshan, Af, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend ≤ 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers

Published
2013

57. History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium

Author

Stott Miller, M, Chen, Chen, Chuang, S, Lee, Ya, Boccia, Stefania, Brenner, H, Cadoni, Gabriella, Dal Maso, L, La Vecchia, C, Lazarus, P, Levi, F, Matsuo, K, Morgenstern, H, Müller, H, Muscat, J, Olshan, Af, Purdue, Mp, Serraino, D, Vaughan, Tl, Zhang, Z, Boffetta, P, Hashibe, M, Schwartz, Sm, Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Stott Miller, M, Chen, Chen, Chuang, S, Lee, Ya, Boccia, Stefania, Brenner, H, Cadoni, Gabriella, Dal Maso, L, La Vecchia, C, Lazarus, P, Levi, F, Matsuo, K, Morgenstern, H, Müller, H, Muscat, J, Olshan, Af, Purdue, Mp, Serraino, D, Vaughan, Tl, Zhang, Z, Boffetta, P, Hashibe, M, Schwartz, Sm, Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)

Abstract

Background: A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention. Methods: We pooled data from 12 case control studies including 6,448 cases and 13,747 controls, and estimated OR and 95% CI for the associations between diabetes and HNC, adjusted for age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use, and body mass index. Results: We observed a weak association between diabetes and the incidence of HNC overall (OR, 1.09; 95% CI: 0.95-1.24). However, we observed a modest association among never smokers (OR, 1.59; 95% CI: 1.22-2.07), and no association among ever smokers (OR, 0.96; 95% CI: 0.83-1.11); likelihood ratio test for interaction P = 0.001 Conclusion: A history of diabetes was weakly associated with HNC overall, but we observed evidence of effect modification by smoking status, with a positive association among those who never smoked cigarettes. Impact: This study suggests that glucose metabolism abnormalities may be a HNC risk factor in subgroups of the population. Prospective studies incorporating biomarkers are needed to improve our understanding of the relationship between diabetes and HNC risk, possibly providing new strategies in the prevention of HNC

Published
2012

58. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Author

Chuang, S, Jenab, M, Heck, Je, Bosetti, C, Talamini, R, Matsuo, K, Castellsague, X, Franceschi, S, Herrero, R, Winn, Dm, La Vecchia, C, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, Md, Vaughan, T, Lazarus, P, Muscat, J, Ramroth, H, Chen, Chen, Schwartz, Sm, Eluf Neto, J, Hayes, Rb, Purdue, M, Boccia, Stefania, Cadoni, Gabriella, Zaridze, D, Koifman, S, Curado, Mp, Ahrens, W, Benhamou, S, Matos, E, Lagiou, P, Szeszenia Dabrowska, N, Olshan, Af, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Merletti, F, Macfarlane, Gj, Kjaerheim, K, Mates, D, Holcatova, I, Schantz, S, Yu, G, Simonato, L, Brenner, H, Mueller, H, Conway, Di, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, Cm, Ferro, Giorgia, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Chuang, S, Jenab, M, Heck, Je, Bosetti, C, Talamini, R, Matsuo, K, Castellsague, X, Franceschi, S, Herrero, R, Winn, Dm, La Vecchia, C, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, Md, Vaughan, T, Lazarus, P, Muscat, J, Ramroth, H, Chen, Chen, Schwartz, Sm, Eluf Neto, J, Hayes, Rb, Purdue, M, Boccia, Stefania, Cadoni, Gabriella, Zaridze, D, Koifman, S, Curado, Mp, Ahrens, W, Benhamou, S, Matos, E, Lagiou, P, Szeszenia Dabrowska, N, Olshan, Af, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Merletti, F, Macfarlane, Gj, Kjaerheim, K, Mates, D, Holcatova, I, Schantz, S, Yu, G, Simonato, L, Brenner, H, Mueller, H, Conway, Di, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, Cm, Ferro, Giorgia, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)

Abstract

We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).

Published
2012

59. Erratum: Recreational physical activity and risk of head and neck cancer: A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium (European Journal of Epidemiology DOI: 10.1007/s10654-011- 9612-3)

Author

Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., and Boccia S. (ORCID:0000-0002-1864-749X)

Published
2011

60. Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium

Author

Chuang, S, Agudo, A, Ahrens, W, Anantharaman, D, Benhamou, S, Boccia, Stefania, Chen, Chen, Conway, Di, Fabianova, E, Hayes, Rb, Healy, Cm, Holcatova, I, Kjaerheim, K, Lagiou, P, Lazarus, P, Macfarlane, Tv, Mahimkar, Mb, Mates, D, Matsuo, K, Merletti, F, Metspalu, A, Morgenstern, H, Muscat, J, Cadoni, Gabriella, Olshan, Af, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, Sm, Simonato, L, Smith, Em, Sturgis, Em, Szeszenia Dabrowska, N, Talamini, R, Thomson, P, Wei, Q, Zaridze, D, Zhang, Z, Znaor, A, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Chuang, S, Agudo, A, Ahrens, W, Anantharaman, D, Benhamou, S, Boccia, Stefania, Chen, Chen, Conway, Di, Fabianova, E, Hayes, Rb, Healy, Cm, Holcatova, I, Kjaerheim, K, Lagiou, P, Lazarus, P, Macfarlane, Tv, Mahimkar, Mb, Mates, D, Matsuo, K, Merletti, F, Metspalu, A, Morgenstern, H, Muscat, J, Cadoni, Gabriella, Olshan, Af, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, Sm, Simonato, L, Smith, Em, Sturgis, Em, Szeszenia Dabrowska, N, Talamini, R, Thomson, P, Wei, Q, Zaridze, D, Zhang, Z, Znaor, A, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)

Abstract

Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

Published
2011

61. Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

Author

Nicolotti, Nicola, Chuang, S, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, C, Brenner, H, Hosono, S, La Vecchia, C, Talamini, R, Matsuo, K, Müller, H, Muscat, J, Paludetti, Gaetano, Ricciardi, Walter, Boffetta, P, Hashibe, M, Boccia, Stefania, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Nicolotti, Nicola, Chuang, S, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, C, Brenner, H, Hosono, S, La Vecchia, C, Talamini, R, Matsuo, K, Müller, H, Muscat, J, Paludetti, Gaetano, Ricciardi, Walter, Boffetta, P, Hashibe, M, Boccia, Stefania, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

Increasing evidence suggests that physical activity could prevent cancer, but scanty data is available on head and neck cancer (HNC). The aim of our study is to clarify the effect of recreational physical activity (rPA) on HNC. We analyzed data from four case-control studies, including 2,289 HNC cases and 5,580 controls. rPA was classified as: none/low (reference group), moderate and high. We calculated summary Odds Ratios (ORs) by pooling study-specific ORs. Overall, moderate rPA was associated with 22% lower risk of HNC compared to those with none or very low rPA levels [OR = 0.78, 95% Confidence Interval (95% CI): 0.66, 0.91]. Moderate rPA is associated with reduced risk of oral (OR = 0.74, 95% CI: 0.56, 0.97) and pharyngeal cancer (OR = 0.67, 95% CI: 0.53, 0.85), as well as high rPA levels (OR = 0.53, 95% CI: 0.32, 0.88 for oral cavity, OR = 0.58, 95% CI: 0.38, 0.89 for pharynx). High rPA levels, however, is associated with higher risk of laryngeal cancer (OR = 1.73, 95% CI: 1.04, 2.88). Stratified analyses showed that such inverse association between moderate rPA and HNC was more evident among males (OR = 0.75, 95% CI: 0.62, 0.90), subjects ≥45 years (OR = 0.78, 95% CI: 0.66, 0.93), and ever smokers and ever drinkers (OR = 0.72, 95% CI: 0.59, 0.88). High rPA significantly reduces HNC risk among subject ≥45 years (OR = 0.66, 95% CI: 0.48, 0.91). Promoting rPA might be inversely associated with HNC.

Published
2011

67. Previous Lung Diseases and Lung Cancer Risk: A Pooled Analysis From the International Lung Cancer Consortium

Author

Brenner, D. R., primary, Boffetta, P., additional, Duell, E. J., additional, Bickeboller, H., additional, Rosenberger, A., additional, McCormack, V., additional, Muscat, J. E., additional, Yang, P., additional, Wichmann, H.- E., additional, Brueske-Hohlfeld, I., additional, Schwartz, A. G., additional, Cote, M. L., additional, Tjonneland, A., additional, Friis, S., additional, Le Marchand, L., additional, Zhang, Z.-F., additional, Morgenstern, H., additional, Szeszenia-Dabrowska, N., additional, Lissowska, J., additional, Zaridze, D., additional, Rudnai, P., additional, Fabianova, E., additional, Foretova, L., additional, Janout, V., additional, Bencko, V., additional, Schejbalova, M., additional, Brennan, P., additional, Mates, I. N., additional, Lazarus, P., additional, Field, J. K., additional, Raji, O., additional, McLaughlin, J. R., additional, Liu, G., additional, Wiencke, J., additional, Neri, M., additional, Ugolini, D., additional, Andrew, A. S., additional, Lan, Q., additional, Hu, W., additional, Orlow, I., additional, Park, B. J., additional, and Hung, R. J., additional

Published
2012
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70. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Author

Marron, M., primary, Boffetta, P., additional, Zhang, Z.-F., additional, Zaridze, D., additional, Wunsch-Filho, V., additional, Winn, D. M, additional, Wei, Q., additional, Talamini, R., additional, Szeszenia-Dabrowska, N., additional, Sturgis, E. M, additional, Smith, E., additional, Schwartz, S. M, additional, Rudnai, P., additional, Purdue, M. P, additional, Olshan, A. F, additional, Eluf-Neto, J., additional, Muscat, J., additional, Morgenstern, H., additional, Menezes, A., additional, McClean, M., additional, Matos, E., additional, Mates, I. N., additional, Lissowska, J., additional, Levi, F., additional, Lazarus, P., additional, Vecchia, C. L., additional, Koifman, S., additional, Kelsey, K., additional, Herrero, R., additional, Hayes, R. B, additional, Franceschi, S., additional, Fernandez, L., additional, Fabianova, E., additional, Daudt, A. W, additional, Maso, L. D., additional, Curado, M. P., additional, Cadoni, G., additional, Chen, C., additional, Castellsague, X., additional, Boccia, S., additional, Benhamou, S., additional, Ferro, G., additional, Berthiller, J., additional, Brennan, P., additional, Moller, H., additional, and Hashibe, M., additional

Published
2009
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71. Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies

Author

Lubin, J. H., primary, Purdue, M., additional, Kelsey, K., additional, Zhang, Z.-F., additional, Winn, D., additional, Wei, Q., additional, Talamini, R., additional, Szeszenia-Dabrowska, N., additional, Sturgis, E. M., additional, Smith, E., additional, Shangina, O., additional, Schwartz, S. M., additional, Rudnai, P., additional, Neto, J. E., additional, Muscat, J., additional, Morgenstern, H., additional, Menezes, A., additional, Matos, E., additional, Mates, I. N., additional, Lissowska, J., additional, Levi, F., additional, Lazarus, P., additional, Vecchia, C. L., additional, Koifman, S., additional, Herrero, R., additional, Franceschi, S., additional, Wunsch-Filho, V., additional, Fernandez, L., additional, Fabianova, E., additional, Daudt, A. W., additional, Maso, L. D., additional, Curado, M. P., additional, Chen, C., additional, Castellsague, X., additional, Brennan, P., additional, Boffetta, P., additional, Hashibe, M., additional, and Hayes, R. B., additional

Published
2009
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73. Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Hashibe, M., primary, Brennan, P., additional, Benhamou, S., additional, Castellsague, X., additional, Chen, C., additional, Curado, M. P., additional, Maso, L. D., additional, Daudt, A. W., additional, Fabianova, E., additional, Wunsch-Filho, V., additional, Franceschi, S., additional, Hayes, R. B., additional, Herrero, R., additional, Koifman, S., additional, La Vecchia, C., additional, Lazarus, P., additional, Levi, F., additional, Mates, D., additional, Matos, E., additional, Menezes, A., additional, Muscat, J., additional, Eluf-Neto, J., additional, Olshan, A. F., additional, Rudnai, P., additional, Schwartz, S. M., additional, Smith, E., additional, Sturgis, E. M., additional, Szeszenia-Dabrowska, N., additional, Talamini, R., additional, Wei, Q., additional, Winn, D. M., additional, Zaridze, D., additional, Zatonski, W., additional, Zhang, Z.-F., additional, Berthiller, J., additional, and Boffetta, P., additional

Published
2007
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79. The hardest known oxide

Author

Dubrovinsky, L. S., primary, Dubrovinskaia, N. A., additional, Swamy, V., additional, Muscat, J., additional, Harrison, N. M., additional, Ahuja, R., additional, Holm, B., additional, and Johansson, B., additional

Published
2001
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94. IMPOSEX AS SURVEILLANCE BIOMONITORING TOOL OF POLLUTION BY THE ANTIFOULING AGENT, TBT AFTER ITS BAN: MALTA, A CASE STUDY.

Author

Axiak, V., Galea, S., Guillaumier, R., Herrera, P., Micallef, D., Muscat, J., and Vella, N.

Abstract

Tributyl tin (TBT) has been banned as an antifouling agent in the maritime sector over the past few years, due to its impact on a wide range of non-target marine species. This includes imposex induction in prosobranch gastropods. The Maltese Archipelago was one of the first sites within the Mediterranean, where, imposex in the marine snail, Hexaplex trunculus was first used as a biomonitor to assess environmental levels of TBT. Subsequently, this same species was used in several other Mediterranean coastal areas for the same purpose. Imposex levels in Hexa plex trunculus have been studied in Malta since 1993, and have been ongoing since then. The present study will report on the trends in such imposex biomonitoring over the past 18 years in populations of H. trunculus from 13 different inshore coastal areas around the Maltese islands (Malta and Gozo). It concludes that levels of imposex have been declining in this species. Furthermore, the incidence of normal females completely free from imposex in some places, has been on the increase (it is worthwhile to note that prior to 2005 all sampled females of this species showed evidence of imposex)., Nonetheless, imposex is still being recorded, including in marine protected areas. Furthermore, different imposex developmental expressions have been identified in some localities, with some of such expressions probably rendering female specimens more susceptible to early death. [ABSTRACT FROM AUTHOR]

Published
2012

95. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.

Author

Chuang SC, Jenab M, Heck JE, Bosetti C, Talamini R, Matsuo K, Castellsague X, Franceschi S, Herrero R, Winn DM, La Vecchia C, Morgenstern H, Zhang ZF, Levi F, Dal Maso L, Kelsey K, McClean MD, Vaughan T, Lazarus P, and Muscat J

Abstract

We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97). [ABSTRACT FROM AUTHOR]

Published
2012
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96. OAC Musca soybean

Author

Beversdorf, W. D., primary, Hume, D. J., additional, Gostovic, P., additional, Muscat, J. C., additional, and Pararajasingham, S., additional

Published
1991
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97. OAC Dorado soybean

Author

Beversdorf, W. D., primary, Hume, D. J., additional, Gostovic, P., additional, Muscat, J. C., additional, and Pararajasingham, S., additional

Published
1991
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98. OAC TRIUMPH SUMMER RAPE

Author

BEVERSDORF, W. D., primary, HUME, D. J., additional, GOSTOVIC, P., additional, CHU, G., additional, MONTMINY, W., additional, and MUSCAT, J., additional

Published
1990
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