55 results on '"Murray, Phillip"'
Search Results
52. Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO
- Author
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Justin Cotney, M. Necmettin Pamir, Koray Özduman, Ahmet Okay Caglayan, Emre Ceyhun, Saliha Yilmaz, Leman Sencar, Eric C. Holland, Ryan Hebert, Geneive Carrión-Grant, Joseph M. Piepmeier, Yasar Bayri, Timucin Avsar, Ketu Mishra-Gorur, Jun Yin, Katsuhito Yasuno, Octavian Henegariu, Hanwen Bai, Jennifer Moliterno Günel, Joachim M. Baehring, Alexander O. Vortmeyer, Richard P. Lifton, Murat Gunel, Cameron Brennan, Victoria E. Clark, Matthew W. State, E. Zeynep Erson-Omay, Philip H. Gutin, Turker Kilic, Akdes Serin, Phillip B. Murray, Mehmet Bakırcıoğlu, S. Bulent Omay, Luis Kolb, Murim Choi, Baran Yılmaz, Bahattin Tanrıkulu, Jie Li, Shrikant Mane, John D. Overton, A. Fatih Atik, Hande Kaymakçalan, Kaya Bilguvar, James P. Noonan, Conor Grady, Clark, Victoria E., Erson-Omay, E. Zeynep, Serin, Akdes, Yin, Jun, Cotney, Justin, Oezduman, Koray, Avsar, Timuin, Li, Jie, Murray, Phillip B., Henegariu, Octavian, Yilmaz, Saliha, Guenel, Jennifer Moliterno, Carrion-Grant, Geneive, Yilmaz, Baran, Grady, Conor, Tanrikulu, Bahattin, Bakircioglu, Mehmet, Kaymakcalan, Hande, Caglayan, Ahmet Okay, Sencar, Leman, Ceyhun, Emre, Atik, A. Fatih, Bayri, Yasar, Bai, Hanwen, Kolb, Luis E., Hebert, Ryan M., Omay, S. Bulent, Mishra-Gorur, Ketu, Choi, Murim, Overton, John D., Holland, Eric C., Mane, Shrikant, State, Matthew W., Bilguevar, Kaya, Baehring, Joachim M., Gutin, Philip H., Piepmeier, Joseph M., Vortmeyer, Alexander, Brennan, Cameron W., Pamir, M. Necmettin, Kilic, Tuerker, Lifton, Richard P., Noonan, James P., Yasuno, Katsuhito, Guenel, Murat, and Acibadem University Dspace
- Subjects
Genome instability ,Male ,Chromosomes, Human, Pair 22 ,Mutant ,DNA Mutational Analysis ,medicine.disease_cause ,Receptors, G-Protein-Coupled ,Receptors ,80 and over ,Meningeal Neoplasms ,Cancer ,Genetics ,Aged, 80 and over ,Mutation ,Multidisciplinary ,biology ,Brain Neoplasms ,Genomics ,Middle Aged ,Smoothened Receptor ,Hedgehog signaling pathway ,Tumor Necrosis Factor Receptor-Associated Peptides and Proteins ,Ubiquitin ligase ,Female ,Meningioma ,Human ,Adult ,Neurofibromatosis 2 ,General Science & Technology ,Kruppel-Like Transcription Factors ,Chromosomes ,Genomic Instability ,G-Protein-Coupled ,Kruppel-Like Factor 4 ,Rare Diseases ,Genes, Neurofibromatosis 2 ,medicine ,Humans ,Transcription factor ,Aged ,Human Genome ,Neurosciences ,medicine.disease ,Brain Disorders ,Brain Cancer ,Genes ,biology.protein ,Pair 22 ,Neoplasm Grading ,Chromosome 22 ,Proto-Oncogene Proteins c-akt - Abstract
Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within the layer of tissue covering the brain, these tumors are usually slow-growing and benign but can cause serious neurological complications. About half of these tumors have mutations in the neurofibromin 2 gene ( NF2 ). To identify other genes that contribute to meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. Meningiomas fell into two general classes: benign tumors located at the skull base—which tend to harbor mutations in the TRAF7, KLF4, AKT1 , and SMO genes—and higher-grade tumors located in the cerebral and cerebellar hemispheres harbor mutations in NF2.
- Published
- 2013
53. Understanding spatial variability of soil properties: a key step in establishing field- to farm-scale agro-ecosystem experiments†.
- Author
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Peukert, Sabine, Bol, Roland, Roberts, William, Macleod, Christopher J. A., Murray, Phillip J., Dixon, Elizabeth R., and Brazier, Richard E.
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- 2013
- Full Text
- View/download PDF
54. Integrated genomic characterization of IDH1-mutant glioma malignant progression.
- Author
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Bai H, Harmancı AS, Erson-Omay EZ, Li J, Coşkun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan Ş, Bakırcığlu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altınok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, and Günel M
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- Central Nervous System Neoplasms pathology, DNA Methylation, Embryonic Stem Cells metabolism, Forkhead Box Protein M1, Forkhead Transcription Factors genetics, Forkhead Transcription Factors metabolism, Gene Dosage, Gene Expression Regulation, Neoplastic, Genes, myc, Glioma pathology, Humans, Isocitrate Dehydrogenase metabolism, Phosphatidylinositol 3-Kinases genetics, Phosphatidylinositol 3-Kinases metabolism, Receptor, Notch1 genetics, Receptor, Notch1 metabolism, Central Nervous System Neoplasms genetics, Glioma genetics, Isocitrate Dehydrogenase genetics, Mutation
- Abstract
Gliomas represent approximately 30% of all central nervous system tumors and 80% of malignant brain tumors. To understand the molecular mechanisms underlying the malignant progression of low-grade gliomas with mutations in IDH1 (encoding isocitrate dehydrogenase 1), we studied paired tumor samples from 41 patients, comparing higher-grade, progressed samples to their lower-grade counterparts. Integrated genomic analyses, including whole-exome sequencing and copy number, gene expression and DNA methylation profiling, demonstrated nonlinear clonal expansion of the original tumors and identified oncogenic pathways driving progression. These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells. Our results not only provide mechanistic insight into the genetic and epigenetic mechanisms driving glioma progression but also identify inhibition of the bromodomain and extraterminal (BET) family as a potential therapeutic approach.
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- 2016
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55. The Vitamin E analog Trolox reduces copper toxicity in the annelid Lumbriculus variegatus but is also toxic on its own.
- Author
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O'Gara BA, Murray PM, Hoyt EM, Leigh-Logan T, and Smeaton MB
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- Analysis of Variance, Animals, Copper toxicity, Dose-Response Relationship, Drug, Drug Administration Routes, Drug Interactions, Drug-Related Side Effects and Adverse Reactions, Electromyography methods, Lethal Dose 50, Movement drug effects, Muscles drug effects, Nerve Fibers drug effects, Neural Conduction drug effects, Oligochaeta drug effects, Swimming, Chromans toxicity, Copper antagonists & inhibitors
- Abstract
The ability of the water-soluble Vitamin E analog, Trolox, to prevent the toxic effects of copper exposure on the behavior and neuronal physiology of the freshwater oligochaete Lumbriculus variegatus was examined. Trolox produced a concentration-dependent increase in the 24 h LC(50) for copper exposure, with 100 microM Trolox elevating the LC(50) by almost seven-fold (from 0.36 to 2.43 microM). Copper exposure (0.2 microM) for 24h produced a reduction in the conduction velocity of the medial and lateral giant nerve fibers, which was prevented by 100 microM Trolox. Copper exposure (0.2 microM) for 24h also reduced the effectiveness of substrate vibration in eliciting giant nerve fiber spikes. Trolox prevented this reduction in sensory responsiveness. Trolox (100 microM) partially reversed the copper-induced (0.4 microM) decrease in touch-evoked helical swimming behavior, but had no effect on the copper-induced decrement in touch-evoked body reversal. Copper exposure (0.2 microM) for 24 h reduced the amount of spontaneous locomotion (crawling); however, Trolox did not reverse this effect. However, Trolox exposure alone produced a decrease in the distance crawled that was similar in magnitude to copper exposure. In normal worms, rapid spiking activity of the medial giant nerve fiber produces facilitation in the amplitude of the resulting muscle potentials produced by the longitudinal body wall muscles. Copper exposure had no effect on the amount of muscle potential facilitation, but Trolox exposure (100 microM) produced a significant decrease in facilitation. The results of this study indicate that many of the toxic effects of copper exposure on Lumbriculus are prevented or reduced by the antioxidant Trolox. However, the results of this study also indicate that Trolox has toxic effects on behavior and neuronal physiology. The results presented here document one of the few published reports of the detrimental effects of Vitamin E or its analogs on nervous system function or behavior.
- Published
- 2006
- Full Text
- View/download PDF
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