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52. Acute Respiratory Failure Outcomes in Patients with Hematologic Malignancies and Hematopoietic Cell Transplant: A Secondary Analysis of the EFRAIM Study

Author

Munshi, Laveena, Darmon, Michael, Soares, Marcio, Pickkers, Peter, Bauer, Philippe, Meert, Anne-Pascale, Martin-Loeches, Ignacio, Staudinger, Thomas, Pene, Frederic, Antonelli, Massimo, Barratt-Due, Andreas, Demoule, Alexandre, Metaxa, Victoria, Lemiale, Virginie, Taccone, Fabio, Mokart, Djamel, Azoulay, Elie, and Mehta, Sangeeta

Published
2020
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54. Paradigm Shift in ICU Candidacy for Allogeneic Hematopoietic Stem Cell Transplantation: Who, When, and How Long?

Author

García-de-Acilu, Marina, Munshi, Laveena, and Roca, Oriol

Subjects
HEMATOPOIETIC stem cell transplantation, STEM cell transplantation, ADULT respiratory distress syndrome, RENAL replacement therapy, DO-not-resuscitate orders, HEPATIC veno-occlusive disease
Abstract

The article discusses the paradigm shift in the candidacy for intensive care unit (ICU) admission for recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). While advancements in cancer care and critical care management have improved the prognosis for patients with cancer, allo-HSCT recipients have not experienced the same level of progress. The article presents the outcomes of a study conducted in French ICUs, highlighting the clinical heterogeneity of this population and identifying determinants of mortality. The findings suggest the need for a personalized approach to treating allo-HSCT recipients in the ICU based on various factors. The article emphasizes the importance of data-driven approaches, standardized protocols, and collaborative evaluation by hematologists and intensivists to improve outcomes for these patients. [Extracted from the article]

Published
2024
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55. Prone position in ARDS patients: why, when, how and for whom

Author

Guérin, Claude, Albert, Richard K., Beitler, Jeremy, Gattinoni, Luciano, Jaber, Samir, Marini, John J., and Munshi, Laveena

Subjects
Mortality -- France -- United Kingdom, Bedsores -- Health aspects, Health care industry
Abstract

In ARDS patients, the change from supine to prone position generates a more even distribution of the gas-tissue ratios along the dependent-nondependent axis and a more homogeneous distribution of lung stress and strain. The change to prone position is generally accompanied by a marked improvement in arterial blood gases, which is mainly due to a better overall ventilation/perfusion matching. Improvement in oxygenation and reduction in mortality are the main reasons to implement prone position in patients with ARDS. The main reason explaining a decreased mortality is less overdistension in non-dependent lung regions and less cyclical opening and closing in dependent lung regions. The only absolute contraindication for implementing prone position is an unstable spinal fracture. The maneuver to change from supine to prone and vice versa requires a skilled team of 4-5 caregivers. The most frequent adverse events are pressure sores and facial edema. Recently, the use of prone position has been extended to non-intubated spontaneously breathing patients affected with COVID-19 ARDS. The effects of this intervention on outcomes are still uncertain., Author(s): Claude Guérin [sup.1] [sup.2] [sup.3], Richard K. Albert [sup.4], Jeremy Beitler [sup.5], Luciano Gattinoni [sup.6], Samir Jaber [sup.7], John J. Marini [sup.8], Laveena Munshi [sup.9], Laurent Papazian [sup.10] [sup.11], [...]

Published
2020
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57. Diagnostic et traitement du syndrome de detresse respiratoire aigue

Author

Fernando, Shannon M., Ferreyro, Bruno L., Urner, Martin, Munshi, Laveena, and Fan, Eddy

Subjects
Acute respiratory distress syndrome -- Diagnosis -- Care and treatment -- Health aspects, Health
Abstract

Le syndrome de detresse respiratoire aigue (SDRA) est une forme gravissime d'insuffisance respiratoire, caracterisee par une atteinte pulmonaire inflammatoire diffuse aigue (1) qui entrame une augmentation de la permeabilite des [...]

Published
2021
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58. Diagnosis and management of acute respiratory distress syndrome

Author

Fernando, Shannon M., Ferreyro, Bruno L., Urner, Martin, Munshi, Laveena, and Fan, Eddy

Subjects
Acute respiratory distress syndrome -- Diagnosis -- Care and treatment, Health
Abstract

Acute respiratory distress syndrome (ARDS) is a life-threatening form of respiratory failure, characterized by acute, diffuse, inflammatory lung injury, (1) that results in increased alveolar capillary permeability and the development [...]

Published
2021
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61. Association between Arterial Oxygen and Mortality Across Critically Ill Patients with Hematologic Malignancies: Results from an International Collaborative Network

Author

Dumas, Guillaume, primary, Morris, Idunn S, additional, Hensman, Tamishta, additional, Bagshaw, Sean M, additional, Demoule, Alexandre, additional, Ferreyro, Bruno L, additional, Kouatchet, Achille, additional, Lemiale, Virginie, additional, Mokart, Djamel, additional, Pène, Frédéric, additional, Mehta, Sangeeta, additional, Azoulay, Elie, additional, and Munshi, Laveena, additional

Published
2023
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63. Prone positioning for patients with hypoxic respiratory failure related to COVID-19

Author

Venus, Kevin, Munshi, Laveena, and Fralick, Michael

Subjects
Respiratory insufficiency -- Care and treatment, Anoxia -- Care and treatment, Positioning (Patient care) -- Methods, COVID-19 -- Care and treatment -- Complications and side effects, Health
Abstract

Pneumonia is the most common reason for admission to hospital among patients with coronavirus disease 2019 (COVID-19), and many such patients will require supplemental oxygen. (1) Severe pneumonia can result [...]

Published
2020
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64. Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy

Author

Fernando, Shannon M., McIsaac, Daniel I., Rochwerg, Bram, Bagshaw, Sean M., Muscedere, John, Munshi, Laveena, and Ferguson, Niall D.

Subjects
Mortality -- Ontario -- Canada, Long-term care of the sick -- Analysis, Hospital patients -- Patient outcomes -- Prognosis, Tracheostomy -- Analysis, Health care industry, University of Ottawa
Abstract

Purpose Invasive mechanical ventilation is a common form of life support provided to critically ill patients. Frailty is an emerging prognostic factor for poor outcome in the Intensive Care Unit (ICU); however, its association with adverse outcomes following invasive mechanical ventilation is unknown. We sought to evaluate the association between frailty, defined by the Clinical Frailty Scale (CFS), and outcomes of ICU patients receiving invasive mechanical ventilation. Methods We performed a retrospective analysis (2011-2016) of a prospectively collected registry from two hospitals of consecutive ICU patients [greater than or equal to] 18 years of age receiving invasive mechanical ventilation. CFS scores were based on recorded pre-admission function at the time of hospital admission. The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of first liberation attempt, and tracheostomy. Results We included 8110 patients, and 2529 (31.2%) had frailty (CFS [greater than or equal to] 5). Frailty was associated with increased odds of hospital death (adjusted odds ratio [aOR]: 1.24 [95% confidence interval [CI] 1.10-1.40) and discharge to long-term care (aOR 1.21 [95% CI 1.13-1.35]). As compared to patients without frailty, patients with frailty had increased odds of extubation failure (aOR 1.17 [95% CI 1.04-1.37]), hospital death following extubation failure (aOR 1.18 [95% CI 1.07-1.28]), tracheostomy (aOR 1.17 [95% CI 1.01-1.36]), and hospital death following tracheostomy (aOR 1.14 [95% CI 1.03-1.25]). Conclusions The presence of frailty among patients receiving mechanical ventilation is associated with increased odds of hospital mortality, discharge to long-term care, extubation failure, and need for tracheostomy., Author(s): Shannon M. Fernando [sup.1] [sup.2], Daniel I. McIsaac [sup.3] [sup.4] [sup.5], Bram Rochwerg [sup.6] [sup.7], Sean M. Bagshaw [sup.8], John Muscedere [sup.9], Laveena Munshi [sup.10] [sup.11], Niall D. Ferguson [...]

Published
2019
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65. Mortality and costs following extracorporeal membrane oxygenation in critically ill adults: a population-based cohort study

Author

Fernando, Shannon M., Qureshi, Danial, Tanuseputro, Peter, Fan, Eddy, Munshi, Laveena, Rochwerg, Bram, and Talarico, Robert

Subjects
Ontario. Ministry of Health and Long-Term Care -- Analysis, Medical economics -- Economic aspects -- Analysis, Adults -- Economic aspects -- Analysis, Health care industry
Abstract

Purpose Extracorporeal membrane oxygenation (ECMO) is used as temporary cardiorespiratory support in critically ill patients. Little is known about population-level short- and long-term outcomes following ECMO, including healthcare use and health system cost across a wide range of sectors. Methods Population-based cohort study in Ontario, Canada (October 1, 2009-March 31, 2017) of adult patients ([greater than or equal to] 18 years) receiving ECMO for cardiorespiratory support. We captured outcomes through linkage to health administrative databases. Primary outcome was mortality during hospitalization, as well as at 7 days, 30 days, 1 year, 2 years, and 5 years following ECMO initiation. We analyzed health system costs (in Canadian dollars) in the 1 year following the date of the index admission. Results A total of 692 patients were included. Mean (standard deviation [SD]) age was 51.3 (16.0) years. Median (interquartile range [IQR]) time to ECMO initiation from date of admission was 2 (0-9) days. In-hospital mortality was 40.0%. Mortality at 1 year, 2 years, and 5 years was 45.1%, 49.0%, and 57.4%, respectively. Among survivors, 78.4% were discharged home, while 21.2% were discharged to continuing care. Median (IQR) total costs in the 1 year following admission among all patients were Canadian $130,157 (Canadian $58,645-Canadian $240,763), of which Canadian $91,192 (Canadian $38,507-Canadian $184,728) were attributed to inpatient care. Conclusions Hospital mortality among critically ill adults receiving ECMO for advanced cardiopulmonary support is relatively high, but does not markedly increase in the years following discharge. Survivors are more likely to be discharged home than to continuing care. Median costs are high, but largely reflect inpatient hospital costs, and not costs incurred following discharge., Author(s): Shannon M. Fernando [sup.1] [sup.2], Danial Qureshi [sup.3] [sup.4] [sup.20], Peter Tanuseputro [sup.3] [sup.4] [sup.5] [sup.6] [sup.20], Eddy Fan [sup.7] [sup.8], Laveena Munshi [sup.7] [sup.9], Bram Rochwerg [sup.10] [sup.11], [...]

Published
2019
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66. Critical Care Capacity During the COVID-19 Pandemic

Author

Barrett, Kali A., primary, VandeVyvere, Cindy, additional, Haque, Nasim, additional, Gao, Meiyin, additional, Yan, Shujun, additional, Lebovic, Gerald, additional, Ball, Ian, additional, Bodmer, Nicolas S., additional, Born, Karen B., additional, Dhanani, Sonny, additional, Ferguson, Niall D., additional, Neilipovitz, David, additional, Perkhun, Anna, additional, Scott, Michael, additional, Sullivan, Michael, additional, Thériault, Josée, additional, Munshi, Laveena, additional, Slutsky, Arthur S., additional, Jüni, Peter, additional, and Baker, Andrew J., additional

Published
2021
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67. Using the Hospital Frailty Risk Score to assess mortality risk in older medical patients admitted to the intensive care unit

Author

Detsky, Michael E., primary, Shin, Saeha, additional, Fralick, Michael, additional, Munshi, Laveena, additional, Kruser, Jacqueline M., additional, Courtright, Katherine R., additional, Lapointe-Shaw, Lauren, additional, Tang, Terence, additional, Rawal, Shail, additional, Kwan, Janice L., additional, Weinerman, Adina, additional, Razak, Fahad, additional, and Verma, Amol A., additional

Published
2023
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68. Understanding the Post COVID-19 Condition (Long COVID) and the Expected Burden for Ontario

Author

Razak, Fahad, primary, Katz, Gabrielle M., additional, Cheung, Angela M., additional, Herridge, Margaret S., additional, Slutsky, Arthur S., additional, Allen, Upton, additional, Brown, Adalsteinn D., additional, Evans, Gerald A., additional, Kaplan, David M., additional, Mah, Linda, additional, Munshi, Laveena, additional, Manuel, Douglas G., additional, Morris, Andrew M., additional, Rochon, Paula A., additional, Quinn, Kieran L., additional, Sander, Beate, additional, Schwartz, Brian, additional, Siddiqi, Arjumand, additional, Tuite, Ashleigh, additional, Verma, Amol A., additional, Jüni, Peter, additional, and Born, Karen B., additional

Published
2021
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69. The Incidence, Severity, and Management of COVID-19 in Critically Ill Pregnant Individuals

Author

Munshi, Laveena, primary, Wright, Julie K., additional, Zipursky, Jonathan, additional, Jorgensen, Sarah, additional, Bogler, Tali, additional, Miller, Katherine J., additional, Mandhari, Maha Al, additional, Barrett, Kali, additional, Gandhi, Shital, additional, Gundy, Serena, additional, Healey, Andrew, additional, Jüni, Peter, additional, Katz, Gabrielle M., additional, Morris, Andrew M., additional, Pai, Menaka, additional, Perkhun, Anna, additional, Ray, Joel G., additional, Shah, Prakeshkumar, additional, Lapinsky, Stephen E., additional, and Whittle, Wendy L., additional

Published
2021
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70. Heparin Anticoagulation for Hospitalized Patients with COVID-19

Author

Carlin, Stephanie, primary, Morris, Andrew M., additional, Abdurrahman, Zainab B., additional, Bailey, Jacob J., additional, Betts, Martin E., additional, Ciccotelli, William, additional, Langford, Bradley J., additional, Leung, Elizabeth, additional, Maltsev, Antonina, additional, Munshi, Laveena, additional, Neil, Ullanda, additional, Stall, Nathan M., additional, Wadhwa, Anupma, additional, Jüni, Peter, additional, and Pai, Menaka, additional

Published
2021
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74. An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline.

Author

Qadir, Nida, Sahetya, Sarina, Munshi, Laveena, Summers, Charlotte, Abrams, Darryl, Beitler, Jeremy, Bellani, Giacomo, Brower, Roy G., Burry, Lisa, Jen-Ting Chen, Hodgson, Carol, Hough, Catherine L., Lamontagne, Francois, Law, Anica, Papazian, Laurent, Tai Pham, Rubin, Eileen, Siuba, Matthew, Telias, Irene, and Patolia, Setu

Subjects
ADULT respiratory distress syndrome, POSITIVE end-expiratory pressure, PATIENT selection, EXTRACORPOREAL membrane oxygenation, NEUROMUSCULAR blocking agents
Abstract

Background: This document updates previously published Clinical Practice Guidelines for the management of patients with acute respiratory distress syndrome (ARDS), incorporating new evidence addressing the use of corticosteroids, venovenous extracorporeal membrane oxygenation, neuromuscular blocking agents, and positive end-expiratory pressure (PEEP). Methods: We summarized evidence addressing four "PICO questions" (patient, intervention, comparison, and outcome). A multidisciplinary panel with expertise in ARDS used the Grading of Recommendations, Assessment, Development, and Evaluation framework to develop clinical recommendations. Results: We suggest the use of: 1) corticosteroids for patients with ARDS (conditional recommendation, moderate certainty of evidence), 2) venovenous extracorporeal membrane oxygenation in selected patients with severe ARDS (conditional recommendation, low certainty of evidence), 3) neuromuscular blockers in patients with early severe ARDS (conditional recommendation, low certainty of evidence), and 4) higher PEEP without lung recruitment maneuvers as opposed to lower PEEP in patients with moderate to severe ARDS (conditional recommendation, low to moderate certainty), and 5) we recommend against using prolonged lung recruitment maneuvers in patients with moderate to severe ARDS (strong recommendation, moderate certainty). Conclusions: We provide updated evidence-based recommendations for the management of ARDS. Individual patient and illness characteristics should be factored into clinical decision making and implementation of these recommendations while additional evidence is generated from much-needed clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
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75. Ketamine sedation in the intensive care unit: a survey of Canadian intensivists.

Author

Sharif, Sameer, Munshi, Laveena, Burry, Lisa, Mehta, Sangeeta, Gray, Sara, Chaudhuri, Dipayan, Duffett, Mark, Siemieniuk, Reed A., and Rochwerg, Bram

Abstract

Copyright of Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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77. Pourquoi l'interdiction des visites dans les hopitaux durant l'actuelle pandemie de COVID-19 devrait etre assouplie

Author

Munshi, Laveena, Evans, Gerald, and Razak, Fahad

Subjects
Hospitals -- Health aspects -- Laws, regulations and rules -- Ontario, Coronaviruses, Government regulation, Health
Abstract

Pour tenter de limiter la transmission galopante du coronavirus du syndrome respiratoire aigu severe 2 (SRASCoV-2), les hopitaux canadiens ont adopte des politiques d'interdiction des visites durant la premiere vague [...]

Published
2021
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79. Impact of Hospital Visitor Restrictions during the COVID-19 Pandemic

Author

Munshi, Laveena, primary, Odutayo, Ayodele, additional, Evans, Gerald A., additional, Keresteci, Maggie, additional, Drury, Julie, additional, Kain, Dylan, additional, Johnstone, Jennie, additional, Stall, Nathan M., additional, Barrett, Kali, additional, Slutsky, Arthur S., additional, Maltsev, Antonina, additional, Perkhun, Anna, additional, Jüni, Peter, additional, and Razak, Fahad, additional

Published
2021
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80. Remdesivir for Hospitalized Patients with COVID-19

Author

Morris, Andrew M., primary, Juni, Peter, additional, Odutayo, Ayodele, additional, Bobos, Pavlos, additional, Andany, Nisha, additional, Barrett, Kali, additional, Betts, Martin, additional, Healey, Andrew, additional, Langford, Bradley, additional, Maltsev, Antonina, additional, Miller, Katherine J., additional, Morgenstern, Justin, additional, Munshi, Laveena, additional, Razak, Fahad, additional, Stall, Nathan M., additional, and Pai, Menaka, additional

Published
2021
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81. Benefits of Paid Sick Leave During the COVID-19 Pandemic

Author

Thompson, Alison, primary, Stall, Nathan M., additional, Born, Karen B., additional, Gibson, Jennifer L., additional, Allen, Upton, additional, Hopkins, Jessica, additional, Laporte, Audrey, additional, Maltsev, Antonina, additional, McElroy, Roisin, additional, Mishra, Sharmistha, additional, Munshi, Laveena, additional, Odutayo, Ayodele, additional, Pai, Menaka, additional, Proctor, Andrea, additional, Razak, Fahad, additional, Reid, Robert J., additional, Siddiqi, Arjumand, additional, Smylie, Janet, additional, Juni, Peter, additional, and Schwartz, Brian, additional

Published
2021
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82. Strategies to Manage Tocilizumab Supply During the COVID-19 Pandemic

Author

Morris, Andrew M., primary, Bean, Sally, additional, Bell, Chaim M., additional, Betts, Martin, additional, Gibson, Jennifer, additional, Graham, Christopher, additional, Greenberg, Rebecca, additional, Juni, Peter, additional, Justo, Julie Ann, additional, Langford, Bradley, additional, Leung, Elizabeth, additional, McCreary, Erin K., additional, Munshi, Laveena, additional, Murthy, Srinivasan, additional, Raybardhan, Sumit, additional, Stall, Nathan M., additional, Steiner, Robert, additional, and Pai, Menaka, additional

Published
2021
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84. The case for relaxing no-visitor policies in hospitals during the ongoing COVID-19 pandemic

Author

Munshi, Laveena, Evans, Gerald, and Razak, Fahad

Subjects
Infection control -- Methods, Epidemics -- Control, Health facilities -- Social aspects -- Safety and security measures, Health
Abstract

In an attempt to mitigate excess transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Canadian hospitals adopted 'no visitor' policies during the first wave of the pandemic. A reflexive [...]

Published
2021
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85. COVID-19 Hospitalizations, ICU Admissions and Deaths Associated with the New Variants of Concern

Author

Tuite, Ashleigh R., primary, Fisman, David N., additional, Odutayo, Ayodele, additional, Bobos, Pavlos, additional, Allen, Vanessa, additional, Bogoch, Isaac I., additional, Brown, Adalsteinn D., additional, Evans, Gerald A., additional, Greenberg, Anna, additional, Hopkins, Jessica, additional, Maltsev, Antonina, additional, Manuel, Douglas G., additional, McGeer, Allison, additional, Morris, Andrew M., additional, Mubareka, Samira, additional, Munshi, Laveena, additional, Murty, V. Kumar, additional, Patel, Samir N., additional, Razak, Fahad, additional, Reid, Robert J., additional, Sander, Beate, additional, Schull, Michael, additional, Schwartz, Brian, additional, Slutsky, Arthur S., additional, Stall, Nathan M., additional, and Juni, Peter, additional

Published
2021
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86. Tocilizumab for Hospitalized Patients with COVID-19

Author

Morris, Andrew M., primary, Stall, Nathan M., additional, Bobos, Pavlos, additional, Bodmer, Nicolas S., additional, Carlin, Stephanie, additional, Leung, Elizabeth, additional, Maltsev, Antonina, additional, Miller, Katherine J., additional, Munshi, Laveena, additional, Odutayo, Ayodele, additional, Razak, Fahad, additional, Raybardhan, Sumit, additional, Juni, Peter, additional, and Pai, Menaka, additional

Published
2021
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87. ESICM guidelines on acute respiratory distress syndrome:definition, phenotyping and respiratory support strategies

Author

Grasselli, Giacomo, Calfee, Carolyn S., Camporota, Luigi, Poole, Daniele, Amato, Marcelo B.P., Antonelli, Massimo, Arabi, Yaseen M., Baroncelli, Francesca, Beitler, Jeremy R., Bellani, Giacomo, Bellingan, Geoff, Blackwood, Bronagh, Bos, Lieuwe D.J., Brochard, Laurent, Brodie, Daniel, Burns, Karen E.A., Combes, Alain, D’Arrigo, Sonia, De Backer, Daniel, Demoule, Alexandre, Einav, Sharon, Fan, Eddy, Ferguson, Niall D., Frat, Jean Pierre, Gattinoni, Luciano, Guérin, Claude, Herridge, Margaret S., Hodgson, Carol, Hough, Catherine L., Jaber, Samir, Juffermans, Nicole P., Karagiannidis, Christian, Kesecioglu, Jozef, Kwizera, Arthur, Laffey, John G., Mancebo, Jordi, Matthay, Michael A., McAuley, Daniel F., Mercat, Alain, Meyer, Nuala J., Moss, Marc, Munshi, Laveena, Myatra, Sheila N., Ng Gong, Michelle, Papazian, Laurent, Patel, Bhakti K., Pellegrini, Mariangela, Perner, Anders, Pesenti, Antonio, Piquilloud, Lise, Grasselli, Giacomo, Calfee, Carolyn S., Camporota, Luigi, Poole, Daniele, Amato, Marcelo B.P., Antonelli, Massimo, Arabi, Yaseen M., Baroncelli, Francesca, Beitler, Jeremy R., Bellani, Giacomo, Bellingan, Geoff, Blackwood, Bronagh, Bos, Lieuwe D.J., Brochard, Laurent, Brodie, Daniel, Burns, Karen E.A., Combes, Alain, D’Arrigo, Sonia, De Backer, Daniel, Demoule, Alexandre, Einav, Sharon, Fan, Eddy, Ferguson, Niall D., Frat, Jean Pierre, Gattinoni, Luciano, Guérin, Claude, Herridge, Margaret S., Hodgson, Carol, Hough, Catherine L., Jaber, Samir, Juffermans, Nicole P., Karagiannidis, Christian, Kesecioglu, Jozef, Kwizera, Arthur, Laffey, John G., Mancebo, Jordi, Matthay, Michael A., McAuley, Daniel F., Mercat, Alain, Meyer, Nuala J., Moss, Marc, Munshi, Laveena, Myatra, Sheila N., Ng Gong, Michelle, Papazian, Laurent, Patel, Bhakti K., Pellegrini, Mariangela, Perner, Anders, Pesenti, Antonio, and Piquilloud, Lise

Abstract

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients’ representatives on behalf of the ESICM. The review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations and the quality of reporting of each study based on the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network guidelines. The CPG addressed 21 questions and formulates 21 recommendations on the following domains: (1) definition; (2) phenotyping, and respiratory support strategies including (3) high-flow nasal cannula oxygen (HFNO); (4) non-invasive ventilation (NIV); (5) tidal volume setting; (6) positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM); (7) prone positioning; (8) neuromuscular blockade, and (9) extracorporeal life support (ECLS). In addition, the CPG includes expert opinion on clinical practice and identifies the areas of future research.

Published
2023

88. Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts

Author

Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Yarnell, Christopher J., Angriman, Federico, Ferreyro, Bruno L., Liu, Kuan, De Grooth, Harm J., Burry, Lisa, Munshi, Laveena, Mehta, Sangeeta, Celi, Leo, Elbers, Paul, Thoral, Patrick, Brochard, Laurent, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Yarnell, Christopher J., Angriman, Federico, Ferreyro, Bruno L., Liu, Kuan, De Grooth, Harm J., Burry, Lisa, Munshi, Laveena, Mehta, Sangeeta, Celi, Leo, Elbers, Paul, Thoral, Patrick, and Brochard, Laurent

Abstract

Background The optimal thresholds for the initiation of invasive ventilation in patients with hypoxemic respiratory failure are unknown. Using the saturation-to-inspired oxygen ratio (SF), we compared lower versus higher hypoxemia severity thresholds for initiating invasive ventilation. Methods This target trial emulation included patients from the Medical Information Mart for Intensive Care (MIMIC-IV, 2008–2019) and the Amsterdam University Medical Centers (AmsterdamUMCdb, 2003–2016) databases admitted to intensive care and receiving inspired oxygen fraction ≥ 0.4 via non-rebreather mask, noninvasive ventilation, or high-flow nasal cannula. We compared the effect of using invasive ventilation initiation thresholds of SF < 110, < 98, and < 88 on 28-day mortality. MIMIC-IV was used for the primary analysis and AmsterdamUMCdb for the secondary analysis. We obtained posterior means and 95% credible intervals (CrI) with nonparametric Bayesian G-computation. Results We studied 3,357 patients in the primary analysis. For invasive ventilation initiation thresholds SF < 110, SF < 98, and SF < 88, the predicted 28-day probabilities of invasive ventilation were 72%, 47%, and 19%. Predicted 28-day mortality was lowest with threshold SF < 110 (22.2%, CrI 19.2 to 25.0), compared to SF < 98 (absolute risk increase 1.6%, CrI 0.6 to 2.6) or SF < 88 (absolute risk increase 3.5%, CrI 1.4 to 5.4). In the secondary analysis (1,279 patients), the predicted 28-day probability of invasive ventilation was 50% for initiation threshold SF < 110, 28% for SF < 98, and 19% for SF < 88. In contrast with the primary analysis, predicted mortality was highest with threshold SF < 110 (14.6%, CrI 7.7 to 22.3), compared to SF < 98 (absolute risk decrease 0.5%, CrI 0.0 to 0.9) or SF < 88 (absolute risk decrease 1.9%, CrI 0.9 to 2.8). Conclusion Initiating invasive ventilation at lower hypoxemia severity will increase the rate of invasive ventilation, but this can either increase or decrease th

Published
2023

89. In Response

Author

Medische staf Anesthesiologie, van den Bosch, Oscar F C, Chaudhry, Rabail, Wicker, James, Mubashir, Talha, Limb, Daniel, Jogendran, Rohit, Munshi, Laveena, Balki, Mrinalini, Medische staf Anesthesiologie, van den Bosch, Oscar F C, Chaudhry, Rabail, Wicker, James, Mubashir, Talha, Limb, Daniel, Jogendran, Rohit, Munshi, Laveena, and Balki, Mrinalini

Published
2023

90. Dexamethasone in Patients Hospitalized for COVID-19

Author

Jüni, Peter, primary, Odutayo, Ayodele, additional, Allen, Upton, additional, Fisman, David N., additional, Hayes, Anne, additional, Manuel, Douglas G., additional, Munshi, Laveena, additional, Razak, Fahad, additional, Sander, Beate, additional, and Slutsky, Arthur S., additional

Published
2020
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94. Do Thresholds for Invasive Ventilation in Hypoxemic Respiratory Failure Exist? A Cohort Study

Author

Yarnell, Christopher J., primary, Johnson, Alistair, additional, Dam, Tariq, additional, Jonkman, Annemijn, additional, Liu, Kuan, additional, Wunsch, Hannah, additional, Brochard, Laurent, additional, Celi, Leo Anthony, additional, De Grooth, Harm-Jan, additional, Elbers, Paul, additional, Mehta, Sangeeta, additional, Munshi, Laveena, additional, Fowler, Robert A., additional, Sung, Lillian, additional, and Tomlinson, George, additional

Published
2023
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95. Long-term Mental Health Morbidity Among Survivors of COVID-19 Critical Illness – A Population-Based Cohort Study

Author

Slutsky, Arthur, Munshi, Laveena, Talarico, Robert, Fiest, Kirsten, Ferguson, Niall, Fan, Eddy, Vigod, Simone, Myran, Daniel, Brodie, Daniel, Hodgson, Carol L, Fernando, Shannon, Tanuseputro, Peter, Needham, Dale M, Fowler, Robert, McIsaac, Daniel I, Scales, Damon, Qureshi, Danial, Rochwerg, Bram, Cook, Deborah, Herridge, Margaret, Kwado Kyeremanteng, Sood, Manish, and Bienvenu, Joseph

Subjects
Medicine and Health Sciences
Abstract

AUTHORS: Shannon M. Fernando, Danial Qureshi, Robert Talarico, Eddy Fan, Daniel I. McIsaac, Simone N. Vigod, Manish M. Sood, Daniel T. Myran, Carol L. Hodgson, Bram Rochwerg, Laveena Munshi, Kirsten M. Fiest, O. Joseph Bienvenu, Dale M. Needham, Daniel Brodie, Niall D. Ferguson, Robert A. Fowler, Deborah J. Cook, Arthur S. Slutsky, Damon C. Scales, Margaret S. Herridge, Peter Tanuseputro, Kwadwo Kyeremanteng BACKGROUND Severe Coronavirus 2019 (COVID-19) is a common cause of critical illness and intensive care unit (ICU) admission, most often due to hypoxemic respiratory failure. Incidence of ICU admission and hospital mortality among COVID-19 patients has varied geographically and across the duration of the pandemic (Tzotzos et al., Crit Care, 2020). The initial focus of research in critical care focused upon treatments for critically ill COVID-19 patients, and adequate use of resources (Alhazzani et al., Intensive Care Med, 2020; Weissman et al., Ann Intern Med, 2020). Since then, there has been great emphasis upon understanding survivorship after COVID-19 critical illness, and the long-term outcomes among COVID-19 ICU survivors (Hosey and Needham, Nat Rev Dis Primers, 2020). Survivors of critical illness are known to have substantial physical morbidity (Herridge et al., N Engl J Med, 2003; Herridge et al., N Engl J Med, 2011), and existing data also shows that these patients are at increased risk of downstream psychiatric morbidity (Wunsch et al., JAMA, 2014; Sivanathan et al., Intensive Care Med, 2019; Olafson et al., Intensive Care Med, 2021), including suicide and self-harm (Fernando et al., BMJ, 2021). Understanding long-term outcomes among survivors of COVID-19 remains an important avenue for future research (Marshall et al., Lancet Infect Dis, 2020). Survivors of COVID-19 critical illness may have experienced invasive critical care interventions, such as invasive mechanical ventilation and extracorporeal life support (Wunsch, Am J Respir Crit Care Med, 2020; Barbaro et al., Lancet, 2020), treatments that have been associated with higher physical and mental health morbidity (Wunsch et al., JAMA, 2014; Hodgson et al., Lancet Respir Med, 2022; Fernando et al., JAMA, 2022). While existing data suggest that survivors of COVID-19 critical illness may experience substantial physical morbidity (Heesakkers et al., JAMA, 2022), data on mental health morbidity is less clear (Sankar et al., Chest, 2022). Furthermore, how mental health morbidity among survivors of COVID-19 critical illness compares to other survivors of critical illness is unknown, and is an important question as the physical morbidity experienced by these patient populations does not appear to differ (Hodgson et al., Am J Respir Crit Care Med, 2022). We seek to investigate the incidence of long-term mental health morbidity in survivors of COVID-19 critical illness, using population-based data from the province of Ontario, and compare this incidence to other survivors of critical illness, as well as non-ICU hospitalized patients with COVID-19. STUDY OBJECTIVES 1. To describe the sociodemographic characteristics of survivors of COVID-19 critical illness, and to examine the incidence of new mental health diagnoses, and self-harm. 2. To examine if COVID-19 critical illness is associated with a higher incidence of mental health diagnoses among survivors, as compared to ICU survivors without COVID-19; 3. To examine the proportion of COVID-19 critical illness survivors using inpatient (i.e., requiring hospitalization for mental health diagnoses) and outpatient (e.g., visiting a psychiatrist as an outpatient, number of visits within 1-year, time to first visit, and costs related to outpatient resource use) mental health services; 4. To investigate the prognostic factors associated with incident downstream mental health diagnoses among survivors of COVID-19 critical illness. METHODS Data Sources and Setting This will be a population-level cohort study using health administrative databases from the province of Ontario in Canada (population 14.6 million). Within Ontario’s single payer healthcare system, all publicly funded healthcare services, physician, hospital, and demographic information for residents are recorded in administrative databases. These datasets are linked using unique encoded identifiers, and analyzed at ICES, an independent, non-profit research institute whose legal status under Ontario’s health information privacy law allows it to collect and analyze healthcare and demographic data, without consent, for health system evaluation and improvement. ICES is funded by an annual grant from the Ontario Ministry of Health and the Ministry of Long-term Care. Patients are linked across provincial databases using their Ontario Health Insurance Plan (OHIP) number, which is unique to each citizen in Ontario. We will link ten databases at ICES, as performed previously (Fernando et al., BMJ, 2021; Fernando et al., JAMA, 2022) at the individual patient level, from January 1, 2020, through March 31, 2022. Data on illness severity (Multiple Organ Dysfunction Score [MODS]) and co-interventions will be obtained from the Critical Care Information System (CCIS). CCIS provides near-real time information on every patient admitted to a level 2 (designation for those requiring increased observation, those “stepping down” from higher levels of care, or those requiring monitoring and support for an organ system) or level 3 (designation for those requiring advanced respiratory support alone, or monitoring and support for two or more organ systems) critical care unit in Ontario’s acute care hospitals. The system captures data on bed availability, critical care service utilization and patient outcomes. This provides consistent and reliable information on the utilization of critical care resources across the province. The system provides an important medium for monitoring and managing the province’s critical care resources more effectively, and for highlighting opportunities to implement quality improvement initiatives at individual hospitals and across Local Health Integration Networks (LHINs). Data contained in ICES are full and complete, with the exception of emigration from Ontario, which represents approximately 0.5% of patients per year. Patients The entire study period (including outcome ascertainment) will be from January 1, 2020 to September 30, 2022. We will include consecutive adult patients (≥ 18 years of age), with an index intensive care unit (ICU) discharge in Ontario from January 1, 2020, through March 30, 2022, with a diagnosis of COVID-19, and who survived to hospital discharge. For patients with multiple ICU admissions, we will randomly select one admission per patient during the accrual period. We will identify ICU admission through the use of previously validated algorithms from the Canadian Institute for Health Information Discharge Abstract Database (Scales et al., J Clin Epidemiol, 2006). Since routine SARS-CoV-2 testing has been done in Ontario hospitals during the study period, patients with COVID-19 will be identified by a positive polymerase chain reaction (PCR) test for SARS-CoV-2, linked within 14 days to an index admission where the most responsible diagnosis is COVID-19 (using International Classification of Diseases, Version 10 [ICD-10] codes U071 and U072), as performed previously (McNaughton et al., CMAJ, 2022). We will not exclusively rely on PCR testing, due to concerns surrounding incidental positive cases that may be found during ICU admission, particularly in 2022 with the Omicron variant. The primary control group will be adult patients admitted to an ICU with pulmonary infection, but without a positive PCR test for SARS-CoV-2 linked to the index admission, and surviving to hospital discharge. Pulmonary infection will be identified using validated ICD-10 coding for either pneumonia or influenza (J09-J18; Skull et al., Epidemiol Infect, 2010). We will also include additional control groups: 1) Adult patients admitted to the ICU during the study period for any cause, without a positive PCR test for SARS-CoV-2 linked to the index admission, and surviving to hospital discharge; 2) Adult patients admitted to hospital with a positive PCR test for SARS-CoV-2 linked to the index admission, but without ICU admission, and surviving to hospital discharge; and 3) Adult patients with an outpatient positive PCR test for SARS-CoV-2, and not requiring hospital admission within 30 days prior to or after the date of the positive test. We will identify important patient characteristics at the time of the index admission, including age, sex, Charlson comorbidity index (CCI), date of admission, and the number of hospital admissions in the previous year. We will calculate duration of ICU and hospital length of stay from admission and discharge dates. We will obtain neighbourhood income (categorized into quintiles), rurality, and area-level measures of essential worker and visible minority volume through postal code conversion files based on Statistics Canada census data. Recent immigrant status will be captured from the Immigration, Refugees and Citizenship Canada (IRCC) database, which includes all immigration records for people landing in Ontario from 1985 onwards. We will also capture history of pre-existing mental health diagnoses that occurred in the 5 years prior to the index admission, through the use of ICD-10 codes and whether patients had any outpatient mental health visits with a primary care provider or psychiatrist in the previous year (Fernando et al., JAMA, 2022). We will also capture the Charlson Comorbidity Index in the 5 years prior to index admission. Finally, we will record life support interventions received during hospital admission, including invasive mechanical ventilation (delivered through an endotracheal or tracheostomy tube), non-invasive mechanical ventilation (by facemask), renal replacement therapy, tracheostomy, and extracorporeal life support. Outcomes The primary outcome will be incidence of the composite of new mental health diagnoses post-discharge occurring prior to the end of the study period (September 30, 2022), the patient’s date of death, or emigration from Ontario. New mental health diagnoses are categorized in ICES using the Mental Health and Addictions Scorecard (as utilized previously: Gatov et al., Can J Psychiatry, 2017; Fernando et al., JAMA, 2022), and can be noted from either inpatient hospital admissions, or outpatient encounters (including family physician or emergency department visits). This composite outcome includes any of the following: mood or anxiety disorders (depression, anxiety, posttraumatic stress disorder), schizophrenia or psychotic disorders, and other mental health diagnoses (including adjustment reaction, reactive depression, anxiety neurosis, hysteria, neurasthenia, obsessive-compulsive neurosis, personality disorders, sexual deviations, and psychosomatic illness). In addition to a composite variable, we will also separately evaluate the incidence of each of these individual diagnoses. Secondary outcomes include social problems (including economic problems, marital difficulties, family disruption or divorce, parent-child problems, problems with aged parents, educational problems, social maladjustment, occupational problems, and legal problems), substance misuse (secondary to alcohol or drug dependence), and hospital visit for deliberate self-harm. Self-harm behaviour (e.g., deliberate drug overdose or self-inflicted traumatic injury) will be identified using the ICES Mental Health and Addictions Scorecard (Fernando et al., BMJ, 2021; Bayoumi et al., CMAJ Open, 2020). Statistical Analyses We will conduct all statistical analyses using SAS Enterprise Guide 7.1 (SAS Institute, Cary, NC). We will present data as mean values with standard deviations, or medians with interquartile ranges. Based on previous work we anticipate

Published
2023
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96. Cerebrovascular Complications of COVID-19 on Venovenous Extracorporeal Membrane Oxygenation

Author

Zaaqoq, Akram M, Griffee, Matthew J, Kelly, Thu-Lan, Fanning, Jonathon P, Heinsar, Silver, Suen, Jacky Y, Mariani, Silvia, Li Bassi, Gianluigi, Jacobs, Jeffrey P, White, Nicole, Fraser, John F, Lorusso, Roberto, Peek, Giles J, Cho, Sung-Min DO, COVID-19 Critical Care Consortium (COVID Critical), Loforte, Antonino, Al-Dabbous, Tala, Alfoudri, Huda, Shamsah, Mohammed, Elapavaluru, Subbarao, Berg, Ashley, Horn, Christina, Mayasi, Yunis, Schroll, Stephan, Meyer, Dan, Velazco, Jorge, Ploskanych, Ludmyla, Fikes, Wanda, Bagewadi, Rohini, Dao, Marvin, White, Haley, Berrios Laviena, Alondra, Ehlers, Ashley, Shalabi-McGuire, Maysoon, Witt, Trent, Grazioli, Lorenzo, Lorini, Luca, Wilson Grandin, E., Nunez, Jose, Reyes, Tiago, O’Briain, Diarmuid, Hunter, Stephanie, Ramanan, Mahesh, Affleck, Julia, Hurkadli Veerendra, Hemanth, Rai, Sumeet, Russell-Brown, Josie, Nourse, Mary, Joseph, Mark, Mitchell, Brook, Tenzer, Martha, Abe, Ryuzo, Jin Cho, Hwa, Seok Jeong, In, Rahman, Nadeem, Kakar, Vivek, Brozzi, Nicolas, Mehkri, Omar, Krishnan, Sudhir, Duggal, Abhijit, Houltham, Stuart, Graf, Jerónimo, Diaz, Roderigo, Orrego, Roderigo, Delgado, Camila, González, Joyce, Soledad Sanchez, Maria, Piagnerelli, Michael, Rahayu Dewayanti, Josefa, Zabert, Gustavo, Espinosa, Lucio, Delgado, Paulo, Delgado, Victoria, Rincón, Diego Fernando Bautista, Yanten, Angela Maria Marulanda, Bustamante Duque, Melissa, Brodie, Daniel, Elhazmi, Alyaa, Al-Hudaib, Abdullah, Callahan, Maria, Azhari Taufik, M., Yasmin Wardoyo, Elizabeth, Gunawan, Margaretha, Trisnaningrum, Nurindah S, Irawany, Vera, Rayhan, Muhammad, Panigada, Mauro, Pesenti, Antonia, Zanella, Alberto, Leone, Michela, Grasselli, Giacomo, Coppola, Silvia, Colombo, Sebastiano, Antonelli, Massimo, Carelli, Simone, Grieco, Domenico L., Asaki, Motohiro, Hoshino, Kota, Salazar, Leonardo, Duarte, Laura, Laffey, John, Mcnicholas, Bairbre, Cosgrave, David, Mccaffrey, Joseph, Bone, Allison, Hakeem, Yusuff, Winearls, James, Tallott, Mandy, Thomson, David, Arnold-Day, Christel, Cupido, Jerome, Fanie, Zainap, Miller, Malcom, Seymore, Lisa, van Straaten, Dawid, Ait Hssain, Ali, Aliudin, Jeffrey, Alqahtani, Al-Reem, Mohamed, Khoulod, Mohamed, Ahmed, Tan, Darwin, Villanueva, Joy, Zaqout, Ahmed, Kurtzman, Ethan, Ademi, Arben, Dobrita, Ana, El Aoudi, Khadija, Segura, Juliet, Giwangkancana, Gezy, Ohshimo, Shinichiro, Hoshino, Koji, Hitoshi, Saito, Osatnik, Javier, Joosten, Anne, Torres, Antoni, Yang, Minlan, Motos, Ana, Luna, Carlos, Arancibia, Francisco, Williams, Virginie, Noel, Alexandre, Luque, Nestor, Huynh Trung, Trieu, Yacoub, Sophie, Fantini, Marina, García, Ruth Noemi Jorge, Chicote Alvarez, Enrique, Greti, Anna, Ceccato, Adrian, Sanchez, Angel, Loza Vazquez, Ana, Roche-Campo, Ferran, Franch-Llasat, Diego, Tuazon, Divina, Amato, Marcelo, Cassimiro, Luciana, Pola, Flavio, Ribeiro, Francis, Fonseca, Guilherme, Dalton, Heidi, Desai, Mehul, Osborn, Erik, Deeb, Hala, Arcadipane, Antonio, Martucci, Gennaro, Panarello, Giovanna, Vitiello, Chiara, Bianco, Claudia, Occhipinti, Giovanna, Rossetti, Matteo, Cuffaro, Raffaele, Shimizu, Hiroaki, Moriyama, Naoki, Kim, Jae-Burm, Kitamura, Nobuya, Gebauer, Johannes, Yokoyama, Toshiki, Al-Fares, Abdulrahman, Buabbas, Sarah, Alamad, Esam, Alawadhi, Fatma, Alawadi, Kalthoum, Tanaka, Hiro, Hashimoto, Satoru, Yamazaki, Masaki, Tak-Hyuck, Oh, Epler, Mark, Forney, Cathleen, Kruse, Louise, Feister, Jared, Williamson, Joelle, Grobengieser, Katherine, Gnall, Eric, Golden, Sasha, Caroline, Mara, Shapiro, Timothy, Karaj, Colleen, Thome, Lisa, Sher, Lynn, Vanderland, Mark, Welch, Mary, Mcdermott, Sherry, Brain, Matthew, Mineall, Sarah, Kimura, Dai, Brazzi, Luca, Sales, Gabriele, Ogston, Tawnya, Nagpal, Dave, Fischer, Karlee, Rangappa, Rajavardhan, Rai, Sujin, Appu, Argin, Esperatti, Mariano, Carton, Edmund G., Sen, Ayan, Palacios, Amanda, Rainey, Deborah, Samoukoviv, Gordan, Campisi, Josie, Durham, Lucia, Neumann, Emily, Seefeldt, Cassandra, Falcucci, Octavio, Emmrich, Amanda, Guy, Jennifer, Johns, Carling, Potzner, Kelly, Zimmermann, Catherine, Espinal, Angelia, Buchtele, Nina, Schwameis, Michael, Stecher, Stephanie-Susanne, Singh, Delila, Barnikel, Michaela, Arenz, Lukas, Anh Galloway, Lan, Merley, Caitlin, Nichol, Alistair, Csete, Marc, Quesada, Luisa, Saba, Isabela, Kasugai, Daisuke, Hiraiwa, Hiroaki, Tanaka, Taku, Marwali, Eva, Purnama, Yoel, Rahayu Dewayanti, Santi, Ardiyan, Arifa Juzar, Dafsah, Siagian, Debby, Chen, Yih-Sharng, Ogino, Mark, Ratsep, Indrek, Oigus, Getter, Erikson, Kristo, Post, Andra-Maris, Enneveer, Lauri, Sillaots, Piret, Manetta, Frank, Mihelis, Effe, Claire Sarmiento, Iam, Narasimhan, Mangala, Varrone, Michael, Komats, Mamoru, Garcia-Diaz, Julia, Harmon, Catherine, Veena Satyapriya, S., Bhatt, Amar, Mokadam, Nahush A., Uribe, Alberto, Gonzalez, Alicia, Shi, Haixia, Mckeown, Johnny, Pasek, Joshua, Fiorda, Juan, Echeverria, Marco, Moreno, Rita, Zakhary, Bishoy, Cavana, Marco, Cucino, Alberto, Foti, Giuseppe, Giani, Marco, Russotto, Vincenzo, Chiumello, Davide, Castagna, Valentina, Dell’Amore, Andrea, Navalesi, Paolo, Shum, Hoi-Ping, Vuysteke, Alain, Usman, Asad, Acker, Andrew, Smood, Benjamin, Mergler, Blake, Sertic, Federico, Subramanian, Madhu, Sperry, Alexandra, Rizer, Nicolas, Burhan, Erlina, Rasmin, Menaldi, Akmal, Ernita, Sitompul, Faya, Lolong, Navy, Naivedh, Bhat, Erickson, Simon, Barrett, Peter, Dean, David, Daugherty, Julia, Loforte, Antonio, Khan, Irfan, Abraar Quraishi, Mohammed, Desantis, Olivia, Dominic, So, Kandamby, Darshana, Mandei, Jose M., Natanael, Hans, Yudhalantang, Eka, Lantang, Anastasia, Oto Wijaya, Surya, Jung, Anna, George, Ng, Yiu Ng, Wing, Yeung Ng, Pauline, Fang, Shu, Tabah, Alexis, Ratcliffe, Megan, Duroux, Maree, Adachi, Shingo, Nakao, Shota, Blanco, Pablo, Prieto, Ana, Sánchez, Jesús, Nicholson, Meghan, Butt, Warwick, Serratore, Alyssa, Delzoppo, Carmel, Janin, Pierre, Yarad, Elizabeth, Totaro, Richard, Coles, Jennifer, Pujo, Bambang, Balk, Robert, Vissing, Andy, Kapania, Esha, Hays, James, Fox, Samuel, Yantosh, Garrett, Mishin, Pavel, Yuliarto, Saptadi, Hari Santoso, Kohar, Djajalaksana, Susanthy, Zainul Fatoni, Arie, Fukuda, Masahiro, Liu, Keibun, Pelosi, Paolo, Battaglini, Denise, Jiménez, Juan Fernando Masa, Bastos, Diego, Gaião, Sérgio, Rusmawatiningtyas, Desy, Buchner, Jessica, Cho, Young-Jae, Hwan Lee, Su, Kawasaki, Tatsuya, Munshi, Laveena, Sakiyalak, Pranya, Nitayavardhana, Prompak, Seitz, Tamara, Arora, Rakesh, Kent, David, Marino, Daniel, Parwar, Swapnil, Cheng, Andrew, Miller, Jennene, Fujitani, Shigeki, Shimizu, Naoki, Madhok, Jai, Owyang, Clark, Buscher, Hergen, Reynolds, Claire, Maasikas, Olavi, Beljantsev, Aleksan, Mihnovits, Vladislav, Akimoto, Takako, Aizawa, Mariko, Horibe, Kanako, Onodera, Ryota, Hodgson, Carol, Burrell, Aidan, Young, Meredith, George, Timothy, Shekar, Kiran, Mcguinness, Niki, Irvine, Lacey, Flynn, Brigid, Endo, Tomoyuki, Sugiyama, Kazuhiro, Shimizu, Keiki, Fan, Eddy, Exconde, Kathleen, Ichiba, Shingo, Lussier, Leslie, Lotz, Gösta, Malfertheiner, Maximilian, Maier, Lars, Dreier, Esther, Permata Kusumastuti, Neurinda, Mccloskey, Colin, Dabaliz, Al-Awwab, Elshazly, Tarek B, Smith, Josiah, Szuldrzynski, Konstanty S., Bielański, Piotr, Wille, Keith, Murthy, Srinivas, Parhar, Ken Kuljit S., Fiest, Kirsten M., Codan, Cassidy, Shahid, Anmol, Fayed, Mohamed, Evans, Timothy, Garcia, Rebekah, Gutierrez, Ashley, Song, Tae, Rose, Rebecca, Bennett, Suzanne, Richardson, Denise, Arora, Lovkesh, Rappapport, Kristina, Rudolph, Kristina, Sibenaller, Zita, Stout, Lori, Walter, Alicia, Herr, Daniel, Vedadi, Nazli, Bartlett, Robert, Pesenti, Antonio, Thompson, Shaun, Sindt, Lace, Rajnic, Sean, Ewald, Cale, Hoffman, Julie, Ying, Xiaonan, Kennedy, Ryan, Ciullo, Anna, Kida, Yuri, Ferrer Roca, Ricard, Riera, Jordi, Contreras, Sofia, Alegre, Cynthia, Kay, Christy, Fischer, Irene, Renner, Elizabeth, Taniguci, Hayato, Barnett, Adrian, Gibbons, Kristen, Forsyth, Simon, Corley, Amanda, Yang, Ian, Pearse, India, Hinton, Samuel, Abbate, Gabriella, Hassan, Halah, Karnik, Varun A, Katrina, Ki, O'Neill, Hollier F., Obonyo, Nchafatso, Pretti Pimenta, Leticia, Reid, Janice D., Sato, Kei, Vuorinen, Aapeli, Wildi, Karin S., Wood, Emily S., Yerkovich, Stephanie, Lee, James, Plotkin, Daniel, Wanjiru Citarella, Barbara, Merson, Laura, Hartley, Emma, Lubis, Bastian, Ikeyama, Takanari, Bhaskar, Balu, Jung, Jae-Seung, Mcguinness, Shay, Eastwood, Glenn, Rossi Marta, Sandra, Guarracino, Fabio, Gerle, Stacy, Coxon, Emily, Claro, Bruno, Loverde, Daniel, Patil, Namrata, Parrini, Vieri, Mcbride, Angela, Negaard, Kathryn, Ratsch, Angela, Abdelaziz, Ahmad, David Uribe, Juan, Peris, Adriano, Sanders, Mark, Emerson, Dominic, Kamal, Muhammad, Povoa, Pedro, Francis, Roland, Cherif, Ali, Joseph, Sunimol, Di Nardo, Matteo, Heard, Micheal, Kyle, Kimberly, Blackwell, Ray A, Biston, Patrick, Won Jeong, Hye, Smith, Reanna, Prawira, Yogi, Montrucchio, Giorgia, Huerta Garcia, Arturo, Salterain, Nahikari, Meyns, Bart, Moreno, Marsha, Walia, Rajat, Mehta, Amit, Schweda, Annette, Supriatna, Moh, Kirakli, Cenk, Williams, Melissa, Hoon Kim, Kyung, Assad, Alexandra, Giraldo, Estefania, Karolak, Wojtek, Balik, Martin, Pocock, Elizabeth, Gajkowski, Evan, Masafumi, Kanamoto, Barrett, Nicholas, Takeyama, Yoshihiro, Park, Sunghoon, Amin, Faizan, Meilyana Andriyani, Fina, Sudakevych, Serhii, Vera, Magdalena, Cornejo, Rodrigo, Schwarz, Patrícia, Carolina Mardini, Ana, de Paula, Thais, Serpa Neto, Ary, Villoldo, Andrea, Siciliano Colafranceschi, Alexandre, Ubeda Iglesias, Alejandro, Granjean, Juan, Melro, Lívia Maria Garcia, Fioravante Romualdo, Giovana, Gaia, Diego, Souza, Helmgton, Galas, Filomena, Máñez Mendiluce, Rafael, Sosa, Alejandra, Martinez, Ignacio, Kurosawa, Hiroshi, Salgado, Juan, Hugi-Mayr, Beate, Charbonneau, Eric, Salvatore Barzilai, Vitor, Monteiro, Veronica, Ribeiro de Souza, Rodrigo, Harper, Michael, Suzuki, Hiroyuki, Adams, Celina, Brieva, Jorge, Nyale, George, Saleem Eltatar, Faisal, Fatani, Jihan, Baeissa, Husam, Masri, Ayman AL, Rabie, Ahmed, Yee Hui, Mok, Yamane, Masahiro, Jung, Hanna, Mojisola Margaret, Ayorinde, Nacpil, Newell, Ruck, Katja, Bakken, Rhonda, Jara, Claire, Felton, Tim, Berra, Lorenzo, Shah, Bobby, Chakraborty, Arpan, Cardona, Monika, Capatos, Gerry, Akkanti, Bindu, Orija, Abiodun, Jain, Harsh, Ito, Asami, Housni, Brahim, Low, Sennen, Iihara, Koji, Chavez, Joselito, Ramanathan, Kollengode, Naidoo, Krubin, Seppelt, Ian, Vandyk, Marlice, Macdonald, Sarah, Mcgregor, Randy, Siebenaler, Teka, Flynn, Hannah, Lofton, Kristi, Aokage, Toshiyuki, Shigemitsu, Kazuaki, Moscatelli, Andrea, Fiorentino, Giuseppe, Baumgaertel, Matthias, Eddy Mba, Serge, Assy, Jana, Hutahaean, Amelya, Roush, Holly, Sichting, Kay A, Alessandri, Francesco, Burns, Debra, Salt, Gavin, Garabedian, Carl P., Millar, Jonathan, Sim, Malcolm, Mattke, Adrian, Mcauley, Danny, Tadili, Jawad, Frenzel, Tim, Bar-Lavie, Yaron, Blandino Ortiz, Aaron, Stone, Jackie, Attokaran, Antony, Farquharson, Michael, Patel, Brij, Gunning, Derek, Baillie, Kenneth, Watson, Pia, Tamai, Kenji, Ketut Sajinadiyasa, Gede, Kanyawati, Dyah, Salgado, Marcello, Sassine, Assad, Yudo, Bhirowo, Mccaul, Scott, Lee, Bongjin, Min Lee, Sang, Afek, Arnon, Iwashita, Yoshiaki, Pujo Semedi, Bambang, Metiva, Jack, Van Belle, Nicole, Martin-Loeches, Ignacio, Ivatt, Lenny, Yew Woon, Chia, Mi Kang, Hyun, Smith, Timothy, James, Erskine, Al-Rawas, Nawar, Iwasaki, Yudai, Chan King-Chung, Kenny, Gudzenko, Vadim, Taccone, Fabio, Perdhana, Fajar, Lamarche, Yoan, Miguel Ribeiro, Joao, Bradic, Nikola, Van den Bossche, Klaartje, Lansink, Oude, Singh, Gurmeet, Debeuckelaere, Gerdy, Stelfox, Henry T., Cassia, Yi, Elia, Jennifer, Tribble, Thomas, Shankar, Shyam, Padmanabhan, Raj, Hallinan, Bill, Paoletti, Luca, Leyva, Yolanda, Fykuda, Tatuma, Badulak, Jenelle, Koch, Jillian, Hackman, Amy, Janowaik, Lisa, Hernandez, Deb, Osofsky, Jennifer, Donadello, Katia, Lawang, Aizah, Fine, Josh, Davidson, Benjamin, and Vazquez, Andres Oswaldo Razo

Published
2023

97. The association between nutritional risk index and ICU outcomes across hematologic malignancy patients with acute respiratory failure

Author

Kundu, Riddhi, primary, Seeger, Rena, additional, Elfassy, Michael D., additional, Rozenberg, Dmitry, additional, Ahluwalia, Nanki, additional, Detsky, Michael E., additional, Ferreyro, Bruno L., additional, Mehta, Sangeeta, additional, Law, Arjun Datt, additional, Minden, Mark, additional, Prica, Anca, additional, Sklar, Michael, additional, and Munshi, Laveena, additional

Published
2022
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100. Association of Extracorporeal Membrane Oxygenation With New Mental Health Diagnoses in Adult Survivors of Critical Illness

Author

Fernando, Shannon M., primary, Scott, Mary, additional, Talarico, Robert, additional, Fan, Eddy, additional, McIsaac, Daniel I., additional, Sood, Manish M., additional, Myran, Daniel T., additional, Herridge, Margaret S., additional, Needham, Dale M., additional, Hodgson, Carol L., additional, Rochwerg, Bram, additional, Munshi, Laveena, additional, Wilcox, M. Elizabeth, additional, Bienvenu, O. Joseph, additional, MacLaren, Graeme, additional, Fowler, Robert A., additional, Scales, Damon C., additional, Ferguson, Niall D., additional, Combes, Alain, additional, Slutsky, Arthur S., additional, Brodie, Daniel, additional, Tanuseputro, Peter, additional, and Kyeremanteng, Kwadwo, additional

Published
2022
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