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The Tanzania Field Epidemiology and Laboratory Training Program (TFELTP) was established in 2008 as a partnership among the Ministry of Health and Social Welfare (MOHSW), Muhimbili University of Health and Allied Sciences, National Institute for Medical Research, and local and international partners. TFELTP was established to strengthen the capacity of MOHSW to conduct public health surveillance and response, manage national disease control and prevention programs, and to enhance public health laboratory support for surveillance, diagnosis, treatment and disease monitoring. TFELTP is a 2-year full-time training program with approximately 25% time spent in class, and 75% in the field. TFELTP offers two tracks leading to an MSc degree in either Applied Epidemiology or, Epidemiology and Laboratory Management. Since 2008, the program has enrolled a total of 33 trainees (23 males, 10 females). Of these, 11 were enrolled in 2008 and 100% graduated in 2010. All 11 graduates of cohort 1 are currently employed in public health positions within the country. Demand for the program as measured by the number of applicants has grown from 28 in 2008 to 56 in 2011. While training the public health leaders of the country, TFELTP has also provided essential service to the country in responding to high-profile disease outbreaks, and evaluating and improving its public health surveillance systems and diseases control programs. TFELTP was involved in the country assessment of the revised International Health Regulations (IHR) core capabilities, development of the Tanzania IHR plan, and incorporation of IHR into the revised Tanzania Integrated Disease Surveillance and Response (IDSR) guidelines. TFELTP is training a competent core group of public health leaders for Tanzania, as well as providing much needed service to the MOHSW in the areas of routine surveillance, outbreak detection and response, and disease program management. However, the immediate challenges that the program must address include development of a full range of in-country teaching capacity for the program, as well as a career path for graduates.

Background: The United Republic of Tanzania is one of the 22 high M. tuberculosis burden countries. Data collected between 2002 and 2007 indicate that the global prevalence of drug-resistant M. tuberculosis including MDR vary greatly. The varied drug-resistance patterns make continuous surveillance of drug resistance an essential component of tuberculosis control program., Findings: M. tuberculosis isolates were obtained from consenting adult tuberculosis patients involved in a placebo-controlled study to evaluate the efficacy of multivitamin supplements on response to anti-Tb treatment in Dar es Salaam, Tanzania. Antimicrobial susceptibility testing was done on four antimicrobial agents namely streptomycin, isoniazid, ethambutol and rifampicin. HIV testing and CD4+ T lymphocytes enumeration were also done. A total of 280 M. tuberculosis isolates from 191 (68%) males and 89 (32%) female patients with no previous history of anti-tuberculosis treatment exceeding 4 weeks in the previous 12 months were tested. Among these, 133 (47%) patients were HIV seropositive. Fourteen (5.0%) isolates were resistant to any of the anti-tuberculosis drugs. The prevalence of primary resistance was 5.0%, 0.7%, 0.4% and 0% for isoniazid, streptomycin, rifampicin and ethambutol respectively. One isolate (0.4%) was MDR, with resistance to isoniazid, streptomycin and rifampicin., Conclusion: M. Tb primary resistance rate in a selected population in Dar es Salaam Tanzania is low and efforts should be undertaken to support the Tuberculosis program.

The aim of the study was to investigate social and behavioral correlates of perceived vulnerability to traffic injuries in an urban and rural setting in Tanzania. In 2002, a sample of 494 adults aged 15 years and above participated in household interviews in Dar es Salaam (urban) and Hai District (rural). The study was part of a population-based survey that collected self-report data on non-fatal injuries. In Dar es Salaam 75 and 82% of males and females, respectively, perceived it as likely that they would experience a traffic injury in general. The corresponding figures in Hai were 63 and 64%. Men rated their road traffic vulnerability similarly to women (OR=0.8, 95% CI 0.5-1.3). Factors associated with high perceived vulnerability as a pedestrian or being injured by a bicycle were amount of road safety information received from health workers and friends, having caused a car to swerve and having crossed a road while talking. Respondents perceived driver recklessness and driver drunkenness as the leading causes of traffic injuries in both areas. Differences were found between the urban and rural setting with respect to perceived risk for traffic injury. The implications of these findings in the context of traffic injury prevention are discussed.

Background: Injuries are becoming a major health problem in developing countries. Few population based studies have been carried out in African countries. We examined the pattern of nonfatal injuries and associated risk factors in an urban and rural setting of Tanzania., Methods: A population-based household survey was conducted in 2002. Participants were selected by cluster sampling. A total of 8,188 urban and 7,035 rural residents of all ages participated in the survey. All injuries reported among all household members in the year preceding the interview and resulting in one or more days of restricted activity were included in the analysis., Results: A total of 206 (2.5%) and 303 (4.3%) persons reported to have been injured in the urban and rural area respectively. Although the overall incidence was higher in the rural area, the incidence of major injuries (> or = 30 disability days) was similar in both areas. Males were at a higher risk of having an injury than females. Rural residents were more likely to experience injuries due to falls (OR = 1.6; 95% CI = 1.1 - 2.3) and cuts (OR = 4.3; 95% CI = 3.0 - 6.2) but had a lower risk of transport injuries. The most common causes of injury in the urban area were transport injuries and falls. In the rural area, cuts and stabs, of which two thirds were related to agriculture, formed the most common cause. Age was an important risk factor for certain types of injuries. Poverty levels were not significantly associated with experiencing a nonfatal injury., Conclusion: The patterns of injury differ in urban and rural areas partly as a reflection of livelihoods and infrastructure. Rural residents are at a higher overall injury risk than urban residents. This may be important in the development of injury prevention strategies.

This cross-sectional household survey was conducted in Dar es Salaam between July and August 2000. The objectives were to establish the magnitude of rape against women, the perpetrators, disclosure of events and other related factors. Among the 1004 women who completed their interviews, 20% said they were ever raped. The known perpetrators were responsible for 92% of the most recent events. Whereas 34% of events were disclosed for non-legal purposes, only 10% were disclosed to the police. Repeated rape and patterns of disclosure were significantly associated with existing social relationships with the perpetrator. The results indicate that rape against women is a serious public health problem in Dar es Salaam commonly involving people who are close to the victims.

Objectives: To determine the level of knowledge of basic symptoms of cancer of the cervix among Tanzanian females and to determine causes of late presentation with advanced disease among cancer patients., Design: Hospital based cross-sectional study., Setting: Muhimbili National Hospital, Dar es Salaam, Tanzania., Subjects: Eighty nine cervical cancer patients and 178 controls were interviewed between August 1999 and January 2000. Data was analyzed using Epi-Info version 6.04., Results: At Muhimbili National Hospital most patients are admitted in very advanced stages of the disease (Stage IIb and IV). We determined, using a structured questionnaire, knowledge of basic symptoms of cancer of the cervix, attitude and reasons for late presentation among female patients admitted at Muhimbili National Hospital gynaecological ward. The mean age of cases was 48.8(SD11.1) years and the mean parity was 6.7 years were comparable to that of control, which were 45 years(SD10.8) and mean parity of 6.6 respectively. Mean age in years at marriage was lower for cases 17.5(SD 2.9) than controls 18.8(SD3.5). Majority of cases (50.6%) and controls (23.6%) were illiterate, and 21.3% of cases and 33.7% of controls had incomplete primary education. Majority of both cases (47.23%) and controls (56.7%) had no routine gynaecological examination and they did not find it necessary. More than 90% of the cases were in advanced stages of the disease (stage IIb-IV)., Conclusion: Both cases and controls had low knowledge of basic symptoms of cancer of the cervix and as a result most of those who happen to have problems reported late with advanced disease.

Objective: To determine the susceptibility pattern of local strains of Neisseria gonorrhoeae from Dar es salaam, Tanzania to locally used antibiotics., Method: Out of 429 Neisseria gonorrhoeae strains isolated between 1993 and 1995, one hundred and ninety nine were recovered and tested. Minimum inhibitory concentrations (MIC) of penicillin, doxycycline, erythromycin, cefuroxime and ciprofloxacin were determined by the E-test method while that of spectinomycin was measured by the agar dilution method. Penicillinase producing N. gonorrhoeae were identified by the chromogenic cephalosporin method., Results: Of the 199 strains tested 128 (64%) were found to be penicillinase producing Neisseria gonorrhoeae (PPNG). Only 19 (10%) were penicillin sensitive while all penicillin resistant strains were found to be PPNG. One hundred and seventy five (88%), 11(5%) and 13 (7%) of the tested isolates were resistant, less susceptible and fully susceptible to doxycycline respectively. Resistance to cotrimoxazole, cefuroxime and ciprofloxacin was 36 (18%), 11 (6%), and 3 (2%) respectively. The trend of antibiotic susceptibility rates over the three year period of study showed a significant increase in the proportion of susceptible strains to cotrimoxazole. All of the 75 strains tested against spectinomycin were susceptible. There was a statistically significant difference between the susceptibility patterns of non-PPNG and PPNG. Non-PPNG isolates were more susceptible to doxycycline (chi 2 = 78.2, df 2, p = < 0.0001)., Conclusion: These findings have shown that spectinomycin, ciprofloxacin and cefuroxime could continue to be used to treat gonorrhoea in our settings. Continuous surveillance of susceptibility to the commonly used antibiotics is important in order to detect emergence of resistance early and control the possible wide spread of resistant strains.

To determine behavioural risk factors associated with human immunodeficiency virus (HIV) seropositivity among 1104 youth aged 15-24 years we conducted a cross-sectional survey in Moshi rural district in northern Tanzania. Information was obtained about sociodemographic characteristics as well as sexual and reproductive health behaviour. Anonymous blood samples were taken for HIV testing. Positive HIV antibodies were determined and confirmed by two Enzyme-Linked Immunosorbent Assays (ELISA). Of 1104 youth interviewed, 91% (1003) consented for blood specimen taking. Seven out of ten youth volunteered to have had sexual intercourse at least once in their lifetime; 60% reported to consume alcohol and 50% of the sexually experienced females reported to have received a gift for their sexual encounter. The overall HIV seroprevalence was 7.5% (75/1003); females compared to males were twice as likely to be HIV positive, 9.7% and 5% respectively. Behavioural risk factors associated with HIV seropositivity were different in male compared to female youth. Among male subjects, cigarette smoking, ever use of marijuana and having a past history of sexually transmitted diseases (STDs) were significant risk factors associated with increased risk of HIV seropositivity. On the other hand, in females, those with a past or current history of STDs, those who volunteered that they practiced oral sex and subjects with four or more lifetime sexual partners were more likely to be HIV positive than subjects without a history of an STD, those with single sexual partner or had never practiced oral sex. A four fold increased risk of HIV seropositivity was also observed among female subjects with a history of blood transfusion in the previous 10 years compared to having received none, the Odds ratio was 4.1 (95% CI = 1.5, 11.1). The profile of risk behaviour associated with HIV seropositivity calls for an urgent need to target health information and education interventions to bring about a change in behaviour among the youth and hopefully help to reduce the rate of transmission of HIV infection.

Setting: Little is known about the outcome of tuberculosis (TB) treatment and subsequent survival of human immunodeficiency virus (HIV) infected patients treated under routine programme conditions in a developing country. We followed a cohort of HIV-positive and HIV-negative tuberculosis patients during therapy and assessed their vital and tuberculosis status 3 years after completion of treatment in Mwanza, Tanzania., Methods: Newly diagnosed and relapse tuberculosis cases consecutively registered over a 6-month period were enrolled into an epidemiological study of TB/HIV. Treatment outcome was based on information in tuberculosis treatment registers. Patients surviving treatment were assessed 3 years later by personal interview. Cause of death was determined by verbal autopsy., Results: Of 561 patients enrolled into the study, 505 patients alive at completion of treatment were eligible for assessment at 3 years. Except for mortality, HIV infection was not statistically associated with differing treatment outcomes. At time of follow-up, the overall mortality was 19% and was associated with HIV infection (hazard ratio [hr] 3.7, 95% confidence interval [CI] 2.6-5.2) and age 35 years and over (hr 1.5, 95% CI 1.02-2.1), but not with type of tuberculosis, gender, or initial drug resistance. By life table analysis, probability of survival at 4 years was 35% for HIV-positive patients compared to 90% for HIV-negative patients. Although no relapse cases were diagnosed, verbal autopsy suggested equivalent low rates of relapse in both groups., Conclusion: These results demonstrate the effectiveness of the current approach to the treatment of tuberculosis patients regardless of HIV status. However, HIV-related mortality remains high both during and following completion of treatment, and further studies are needed to determine if this mortality might be reduced by simple interventions which are feasible in developing countries.

Male breast cancer is a rare disease. In an African population, the occurrence of this cancer is high. The male/female ratio in Tanzania is 1:14 (0.071). This narrow ratio does not differ significantly in the majority of sub-Saharan African countries. The overall ratio being 0.0143 (CI = 0.0317-0.877). When this was compared with the ratio of the African American population with breast cancer in USA, it was observed to be significantly high (p < 0.05). The narrow male/female ratio amongst indigenous people with breast cancer in sub-Saharan countries was seen only in those geographical areas where cervical malignancy ranked in the leading position. There is a clear association, with a pronounced linear correlation between these two cancers (r = 0.8). In view of this association it is hypothesised that since cervical cancer behaves as a sexually transmitted disease, then possibly this could also be the case in respect to the male breast carcinoma in sub-Saharan Africa. If these results are confirmed by other investigators, an opportunity to examine the factors contributing to the oncogenesis of this disease may be invaluable in developing prevention and treatment strategies.