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51. Challenging the Productivity Mantra: Academic Writing with Spirit in Place

Author

Johnson, Laurel, Roitman, Sonia, Morgan, Ann, and MacLeod, Jason

Abstract

Academic writing groups aim to improve the quality and/or the rate of academic publications. In this article, the authors reflect on a writing group with academic and non-academic members that evolved over two years to uphold a deeper and arguably spiritual purpose. The group commenced with the aim of increasing its members' publication rates, but it developed to be a safe space for members to search for meaning as part of a fellowship of writers. This transition was based in the members' shared commitment to social justice values and individual concerns to generate meaningful research and writing experiences. The group's distinct processes, the shared values of its members and the site of the group meetings in a socially stigmatised community, all work to deepen its purpose beyond academic productivity. Though the group functions to strengthen individual and group norms that contribute to academic productivity, emergent norms and the fellowship of the writers foster a spiritual dimension in the group. This exploration of the spiritual dimension of a writing group adds to the long list of benefits of fellowship through academic writing groups.

Published
2017
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58. A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

Author

Callejas, José Luis, Caminal-Montero, Luis, Corbera-Bellalta, Marc, de Miguel, Eugenio, López, J. Bernardino Díaz, García-Villanueva, María Jesús, Gómez-Vaquero, Carmen, Guijarro-Rojas, Mercedes, Hidalgo-Conde, Ana, Marí-Alfonso, Begoña, Berriochoa, Agustín Martínez, Zapico, Aleida Martínez, Martínez-Taboada, Víctor Manuel, Miranda-Filloy, José A., Monfort, Jordi, Ortego-Centeno, Norberto, Pérez-Conesa, Mercedes, Prieto-González, Sergio, Raya, Enrique, Fernández, Raquel Ríos, Sánchez-Martín, Julio, Sopeña, Bernardo, Tío, Laura, Unzurrunzaga, Ainhoa, Gough, Andrew, Isaacs, John D., Green, Michael, McHugh, Neil, Hordon, Lesley, Kamath, Sanjeet, Nisar, Mohammed, Patel, Yusuf, Yee, Cee-Seng, Stevens, Robert, Nandi, Pradip, Nandagudi, Anupama, Jarrett, Stephen, Li, Charles, Levy, Sarah, Mollan, Susan, Salih, Abdel, Wordsworth, Oliver, Sanders, Emma, Roads, Esme, Gill, Anne, Carr, Lisa, Routledge, Christine, Culfear, Karen, Nugaliyadde, Asanka, James, Lynne, Spimpolo, Jenny, Kempa, Andy, Mackenzie, Felicity, Fong, Rosanna, Peters, Genessa, Rowbotham, Bridie, Masqood, Zahira, Hollywood, Jane, Gondo, Prisca, Wood, Rose, Martin, Steve, Rashid, Lubna Haroon, Robinson, James I., Morgan, Mike, Sorensen, Louise, Taylor, John, Carette, Simon, Chung, Sharon, Cuthbertson, David, Forbess, Lindsy J., Gewurz-Singer, Ora, Hoffman, Gary S., Koening, Curry L., Maksimowicz-McKinnon, Kathleen M., McAlear, Carol A., Moreland, Larry W., Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Spiera, Robert F., Sreih, Antoine, Warrington, Kenneth J., Weisman, Michael, Carmona, F. David, Vaglio, Augusto, Mackie, Sarah L., Hernández-Rodríguez, José, Monach, Paul A., Castañeda, Santos, Solans, Roser, Morado, Inmaculada C., Narváez, Javier, Ramentol-Sintas, Marc, Pease, Colin T., Dasgupta, Bhaskar, Watts, Richard, Khalidi, Nader, Langford, Carol A., Ytterberg, Steven, Boiardi, Luigi, Beretta, Lorenzo, Govoni, Marcello, Emmi, Giacomo, Bonatti, Francesco, Cimmino, Marco A., Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Sailler, Laurent, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Øyvind, Diamantopoulos, Andreas P., Voskuyl, Alexandre, Brouwer, Elisabeth, Daikeler, Thomas, Berger, Christoph T., Molloy, Eamonn S., O’Neill, Lorraine, Blockmans, Daniel, Lie, Benedicte A., Mclaren, Paul, Vyse, Timothy J., Wijmenga, Cisca, Allanore, Yannick, Koeleman, Bobby P.C., Barrett, Jennifer H., Cid, María C., Salvarani, Carlo, Merkel, Peter A., Morgan, Ann W., González-Gay, Miguel A., and Martín, Javier

Published
2017
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59. Diagnostic delay is associated with uveitis and inflammatory bowel disease in AS: a study of extra-musculoskeletal manifestations in SpA.

Author

Michelena, Xabier, Zhao, Sizheng Steven, Marco-Pascual, Carla, Almirall, Miriam, Collantes-Estevez, Eduardo, Font-Ugalde, Pilar, López-Medina, Clementina, Wei, James Cheng-Chung, Morgan, Ann W, Rodríguez, Jesús, Juanola, Xavier, Vázquez-Mellado, Janitzia, and Marzo-Ortega, Helena

Subjects
MUSCULOSKELETAL system diseases, DELAYED diagnosis, PSORIATIC arthritis, RESEARCH, INFLAMMATORY bowel diseases, CONFIDENCE intervals, ANKYLOSING spondylitis, MULTIVARIATE analysis, RETROSPECTIVE studies, UVEITIS, RESEARCH funding, LONGITUDINAL method, PROPORTIONAL hazards models
Abstract

Objectives To examine the prevalence of extra-musculoskeletal manifestations (EMM) and the association between diagnostic delay and their incidence in AS and PsA. Methods This was a retrospective, cohort study comprising two single centre cohorts in Europe and one multicentre cohort in Latin America (RESPONDIA). Crude prevalence of EMMs (uveitis, IBD and psoriasis) was calculated across geographic area and adjusted by direct standardization. Cox proportional hazard analysis was performed to assess the association between diagnostic delay and EMM incidence. Results Of 3553 patients, 2097 had AS and 1456 had PsA. The overall prevalence of uveitis was 22.9% (95% CI: 21.1, 24.8) in AS and 3.8% (95% CI: 2.9, 5.0) in PsA; 8.1% (95% CI: 7.0, 9.4) and 2.1% (1.3, 2.9), respectively, for IBD; and 11.0% (95% CI: 9.7, 12.4) and 94.6% (93.0, 95.9), respectively, for psoriasis. The EMM often presented before the arthritis (uveitis 45.1% and 33.3%, and IBD 37.4% and 70%, in AS and PsA, respectively). In the multivariable model, longer diagnostic delay (≥5 years) associated with more uveitis (hazard ratio [HR] 4.01; 95% CI: 3.23, 4.07) and IBD events (HR 1.85; 95% CI: 1.28, 2.67) in AS. Diagnostic delay was not significantly associated with uveitis (HR 1.57; 95% CI: 0.69, 3.59) or IBD events (HR 1.59; 95% CI: 0.39, 6.37) in PsA. Conclusion EMMs are more prevalent in AS than PsA and often present before the onset of the articular disease. A longer diagnostic delay is associated with the ' de novo ' appearance of uveitis and IBD in AS, highlighting the need to enhance diagnostic strategies to shorten the time from first symptom to diagnosis in SpA. [ABSTRACT FROM AUTHOR]

Published
2024
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61. Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England

Author

Wu, Jianhua, Keeley, Adam, Mallen, Christian, Morgan, Ann W., and Pujades-Rodriguez, Mar

Subjects
Polymyalgia rheumatica -- Diagnosis, Temporal arteritis -- Care and treatment, Infection -- Risk factors, Glucocorticoids -- Dosage and administration -- Complications and side effects, Hospital admission and discharge, Family medicine, Mycoses, Herpes zoster, Medical research, Chronic diseases, Bacterial infections, Prednisolone, Conjunctivitis, Tocilizumab, Herpesvirus infections, Health
Abstract

BACKGROUND: Most patients with polymyalgia rheumatica or giant cell arteritis are treated with glucocorticoid therapy in primary care. We estimated dose-response risks of infection for this population in England. METHODS: We conducted a retrospective record-linkage study involving a cohort of people with polymyalgia rheumatica or giant cell arteritis registered in family practices across England (1998-2017). Estimates of first occurring infection per level of time-variant current and cumulative dose were obtained using Kaplan-Meier methods and multilevel proportional-hazards Cox models. RESULTS: Of 39938 patients attending 389 family practices, 22 234 (55.7%) had at least 1 infection over a median follow-up period of 4.8 years, with 5937 (26.7%) requiring hospital admission and 1616 (7.3%) dying within 7 days of diagnosis. Cumulative risks of all-cause infection were 18.3% (95% confidence interval [CI] 17.9%-18.7%) at 1 year, 54.7% (95% CI 54.1%-55.2%) at 5 years and 76.9% (95% CI 76.2%-77.5%) at 10 years. Lower respiratory tract infections, conjunctivitis and herpes zoster were the most commonly diagnosed infections. The increases in adjusted hazard ratios (HRs) for all-cause infection per 5 mg prednisolone-equivalent daily dose increase and per 1000 mg cumulative dose increase in the last year from the patient's end date of follow-up were 1.13 (95% CI 1.121.14) and 1.50 (95% CI 1.49-1.52), respectively. Adjusted HRs associated with periods of current glucocorticoid versus no glucocorticoid use ranged from 1.48 (95% CI 1.39-1.57) for fungal to 1.70 (95% CI 1.60-1.80) for bacterial infection. Stepwise dose-related associations were found for bacterial, viral, parasitic and fungal infections, irrespective of patient age, duration of underlying chronic disease and baseline vaccination status. INTERPRETATION: We quantified the excess risk of all-cause, bacterial, viral, parasitic and fungal infection conferred by oral glucocorticoids in people with polymyalgia rheumatica or giant cell arteritis and found strong dose responses for all types, even at daily doses of less than 5 mg prednisolone., Polymyalgia rheumatica and giant cell arteritis are chronic inflammatory diseases requiring immunosuppressive therapy with glucocorticoids to induce remission and treat subsequent episodic flares. Most patients with polymyalgia rheumatica or giant [...]

Published
2019
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62. Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

Author

Taylor, John C., Bongartz, Tim, Massey, Jonathan, Mifsud, Borbala, Spiliopoulou, Athina, Scott, Ian C., Wang, Jianmei, Morgan, Michael, Plant, Darren, Colombo, Marco, Orchard, Peter, Twigg, Sarah, McInnes, Iain B., Porter, Duncan, Freeston, Jane E., Nam, Jackie L., Cordell, Heather J., Isaacs, John D., Strathdee, Jenna L., Arnett, Donna, de Hair, Maria J. H., Tak, Paul P., Aslibekyan, Stella, van Vollenhoven, Ronald F., Padyukov, Leonid, Bridges, S. Louis, Pitzalis, Costantino, Cope, Andrew P., Verstappen, Suzanne M. M., Emery, Paul, Barnes, Michael R., Agakov, Felix, McKeigue, Paul, Mushiroda, Taisei, Kubo, Michiaki, Weinshilboum, Richard, Barton, Anne, Morgan, Ann W., Barrett, Jennifer H., on behalf of the MATURA, and PAMERA, and Consortia

Published
2018
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66. Diagnostic delay is associated with uveitis and inflammatory bowel disease in AS: a study of extra-musculoskeletal manifestations in SpA

Author

Michelena, Xabier, primary, Zhao, Sizheng Steven, additional, Marco-Pascual, Carla, additional, Almirall, Miriam, additional, Collantes-Estevez, Eduardo, additional, Font-Ugalde, Pilar, additional, López-Medina, Clementina, additional, Wei, James Cheng-Chung, additional, Morgan, Ann W, additional, Rodríguez, Jesús, additional, Juanola, Xavier, additional, Vázquez-Mellado, Janitzia, additional, and Marzo-Ortega, Helena, additional

Published
2023
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68. P114 Exploring micro-RNA content of circulating extracellular vesicles as biomarkers in early rheumatoid arthritis

Author

Maunder, Daniel, primary, Brown, Philip M, additional, Barron-Millar, Ben, additional, Lendrem, Dennis, additional, Naamane, Najib, additional, Macdonald, Jamie, additional, Wang, Xiao, additional, Anderson, Amy E, additional, Morgan, Ann W, additional, Mackie, Sarah L, additional, Crossland, Rachel, additional, and Pratt, Arthur G, additional

Published
2023
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69. Prevalence of Poorly Controlled Asthma and Factors Associated with Specialist Referral in Those with Poorly Controlled Asthma in a Paediatric Asthma Population

Author

Kallis,Constantinos, Morgan,Ann, Fleming,Louise, Quint,Jennifer, Kallis,Constantinos, Morgan,Ann, Fleming,Louise, and Quint,Jennifer

Abstract

Constantinos Kallis,1,2,&ast; Ann Morgan,1,2,&ast; Louise Fleming,1 Jennifer K Quint1,2 1National Heart and Lung Institute, Imperial College London, London, UK; 2School of Public Health, Imperial College London, London, UK&ast;These authors contributed equally to this workCorrespondence: Jennifer K Quint, National Heart and Lung Institute and School of Public Health, Imperial College London, Sir Michael Uren Building, White City Campus, Imperial College, London, UK, Tel +44 207 594 8821, Email j.quint@imperial.ac.ukBackground: Significant morbidity and mortality are associated with poor asthma control. The aim of this study was to determine factors associated with poor control and referral to specialist secondary care services.Methods: We used primary care data from the Clinical Practice Research Datalink Aurum (CPRD) linked with Hospital Episode Statistics (HES) records from 1st January 2007 to 31st December 2019. We selected patients aged 6– 17 years old. Poor control was defined as six or more prescriptions of short-acting beta-agonist (SABA) inhalers, two or more courses of oral corticosteroids (OCS), an Asthma Control test (ACT) or childhood ACT < 20, one hospital admission for asthma, or one visit to Accident & Emergency (A&E) department for asthma-related episodes in the 12 months following asthma diagnosis. Asthma severity was defined following GINA guidelines 2021.Results: About 17.6% of children aged between 6 and 17 years with active asthma had poor control. Severe asthma, eczema, food allergies, increased BMI and living in deprived areas were identified as risk factors for poor control. Among those with poor control, referral rates to specialist care were extremely low, only 2% overall. Those with severe asthma were three-times more likely to be referred than those with mild-to-moderate asthma [HRcrude = 4.04 (95% CI, 3.35– 4.87); HRadj = 2.72 (95% CI: 2.13– 3.49)]. Other factors associated with referral were food allergy and

Published
2023

70. Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing

Author

European Commission, Instituto de Salud Carlos III, CSIC - Patronato Juan de la Cierva de Investigación Científica y Técnica, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), Instituto Nacional de Salud (España), National Health and Medical Research Council (Australia), Centro de Investigación Biomédica en Red Enfermedades Raras (España), Ortiz-Fernández, Lourdes, Carmona, Elio G., Kerick, Martin, Lyons, Paul, Carmona, Francisco D, López Mejías, Raquel, Khor, Chiea Chuen, Grayson, Peter C., Tombetti, Enrico, Jiang, L., Direskeneli, Haner, Saruhan-Direskeneli, Güher, Callejas-Rubio, José Luis, Vaglio, Augusto, Salvarani, Carlo, Hernández-Rodríguez, José, Cid, María C., Morgan, Ann W., Merkel, Peter A., Burgner, David, Smith, K.G.C., González-Gay, M. A., Sawalha, Amr H., Martin, Javier, Márquez, Ana, European Commission, Instituto de Salud Carlos III, CSIC - Patronato Juan de la Cierva de Investigación Científica y Técnica, National Institute of Arthritis and Musculoskeletal and Skin Diseases (US), Instituto Nacional de Salud (España), National Health and Medical Research Council (Australia), Centro de Investigación Biomédica en Red Enfermedades Raras (España), Ortiz-Fernández, Lourdes, Carmona, Elio G., Kerick, Martin, Lyons, Paul, Carmona, Francisco D, López Mejías, Raquel, Khor, Chiea Chuen, Grayson, Peter C., Tombetti, Enrico, Jiang, L., Direskeneli, Haner, Saruhan-Direskeneli, Güher, Callejas-Rubio, José Luis, Vaglio, Augusto, Salvarani, Carlo, Hernández-Rodríguez, José, Cid, María C., Morgan, Ann W., Merkel, Peter A., Burgner, David, Smith, K.G.C., González-Gay, M. A., Sawalha, Amr H., Martin, Javier, and Márquez, Ana

Abstract

Objectives The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a consequence of the low prevalence of vasculitides. This study aimed to identify new genetic risk loci for the main systemic vasculitides through a comprehensive analysis of their genetic overlap. Methods Genome-wide data from 8467 patients with any of the main forms of vasculitis and 29 795 healthy controls were meta-analysed using ASSET. Pleiotropic variants were functionally annotated and linked to their target genes. Prioritised genes were queried in DrugBank to identify potentially repositionable drugs for the treatment of vasculitis. Results Sixteen variants were independently associated with two or more vasculitides, 15 of them representing new shared risk loci. Two of these pleiotropic signals, located close to CTLA4 and CPLX1, emerged as novel genetic risk loci in vasculitis. Most of these polymorphisms appeared to affect vasculitis by regulating gene expression. In this regard, for some of these common signals, potential causal genes were prioritised based on functional annotation, including CTLA4, RNF145, IL12B, IL5, IRF1, IFNGR1, PTK2B, TRIM35, EGR2 and ETS2, each of which has key roles in inflammation. In addition, drug repositioning analysis showed that several drugs, including abatacept and ustekinumab, could be potentially repurposed in the management of the analysed vasculitides. Conclusions We identified new shared risk loci with functional impact in vasculitis and pinpointed potential causal genes, some of which could represent promising targets for the treatment of vasculitis.

Published
2023

71. Identification of new risk loci and pathways involved in GCA pathogenesis by a genome-wide.

Author

Borrego Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Kerick, Martin, Madrid Paredes, Adela, Vaglio, Augusto, Hernández-Rodríguez, José, Mackie, Sarah, Castañeda, Santos, Solans-Laqué, Roser, Mestre, Jaume, Dasgupta, Bhaskar, Watts, Richard, Khalidi, Nader, Langford, Carol, Ytterberg, Steven R, Beretta, Lorenzo, Govoni, Marcelo, Emmi, Giacomo, Cimmino, Marco A., Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Oyvind, Diamantopoulos, Andreas P., Voskuyl, Alexandre E., Daikeler, Thomas, Berger, Christoph, Molloy, Eamonn, Blockmans, Daniel, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A., Cid, María C., González-Gay, M. A., Morgan, Ann, Martin Ibáñez, Javier, Márquez, Ana, Borrego Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Kerick, Martin, Madrid Paredes, Adela, Vaglio, Augusto, Hernández-Rodríguez, José, Mackie, Sarah, Castañeda, Santos, Solans-Laqué, Roser, Mestre, Jaume, Dasgupta, Bhaskar, Watts, Richard, Khalidi, Nader, Langford, Carol, Ytterberg, Steven R, Beretta, Lorenzo, Govoni, Marcelo, Emmi, Giacomo, Cimmino, Marco A., Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Oyvind, Diamantopoulos, Andreas P., Voskuyl, Alexandre E., Daikeler, Thomas, Berger, Christoph, Molloy, Eamonn, Blockmans, Daniel, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A., Cid, María C., González-Gay, M. A., Morgan, Ann, Martin Ibáñez, Javier, and Márquez, Ana

Published
2023

72. A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

Author

Barclay, Murray, Peyrin-Biroulet, Laurent, Chamaillard, Mathias, Colombel, Jean-Frederick, Cottone, Mario, Croft, Anthony, D’Incà, Renata, Halfvarson, Jonas, Hanigan, Katherine, Henderson, Paul, Hugot, Jean-Pierre, Karban, Amir, Kennedy, Nicholas A., Khan, Mohammed Azam, Lémann, Marc, Levine, Arie, Massey, Dunecan, Milla, Monica, Montgomery, Grant W., Ng, Sok Meng Evelyn, Oikonomou, Ioannis, Peeters, Harald, Proctor, Deborah D., Rahier, Jean-Francois, Roberts, Rebecca, Rutgeerts, Paul, Seibold, Frank, Stronati, Laura, Taylor, Kirstin M., Törkvist, Leif, Ublick, Kullak, Van Limbergen, Johan, Van Gossum, Andre, Vatn, Morten H., Zhang, Hu, Zhang, Wei, Andrews, Jane M., Bampton, Peter A., Florin, Timothy H., Gearry, Richard, Krishnaprasad, Krupa, Lawrance, Ian C., Mahy, Gillian, Radford-Smith, Graham, Roberts, Rebecca L., Simms, Lisa A., Amininijad, Leila, Cleynen, Isabelle, Dewit, Olivier, Franchimont, Denis, Georges, Michel, Laukens, Debby, Theatre, Emilie, Van Gossum, André, Vermeire, Severine, Aumais, Guy, Baidoo, Leonard, Barrie, Arthur M., III, Beck, Karen, Bernard, Edmond-Jean, Binion, David G., Bitton, Alain, Brant, Steve R., Cho, Judy H., Cohen, Albert, Croitoru, Kenneth, Daly, Mark J., Datta, Lisa W., Deslandres, Colette, Duerr, Richard H., Dutridge, Debra, Ferguson, John, Fultz, Joann, Goyette, Philippe, Greenberg, Gordon R., Haritunians, Talin, Jobin, Gilles, Katz, Seymour, Lahaie, Raymond G., McGovern, Dermot P., Nelson, Linda, Ng, Sok Meng, Ning, Kaida, Paré, Pierre, Regueiro, Miguel D., Rioux, John D., Ruggiero, Elizabeth, Schumm, L. Philip, Schwartz, Marc, Scott, Regan, Sharma, Yashoda, Silverberg, Mark S., Spears, Denise, Steinhart, A. Hillary, Stempak, Joanne M., Swoger, Jason M., Tsagarelis, Constantina, Zhang, Clarence, Zhao, Hongyu, Aerts, Jan, Ahmad, Tariq, Arbury, Hazel, Attwood, Anthony, Auton, Adam, Ball, Stephen G., Balmforth, Anthony J., Barnes, Chris, Barrett, Jeffrey C., Barroso, Inês, Barton, Anne, Bennett, Amanda J., Bhaskar, Sanjeev, Blaszczyk, Katarzyna, Bowes, John, Brand, Oliver J., Braund, Peter S., Bredin, Francesca, Breen, Gerome, Brown, Morris J., Bruce, Ian N., Bull, Jaswinder, Burren, Oliver S., Burton, John, Byrnes, Jake, Caesar, Sian, Cardin, Niall, Clee, Chris M., Coffey, Alison J., Connell, John M.C., Conrad, Donald F., Cooper, Jason D., Dominiczak, Anna F., Downes, Kate, Drummond, Hazel E., Dudakia, Darshna, Dunham, Andrew, Ebbs, Bernadette, Eccles, Diana, Edkins, Sarah, Edwards, Cathryn, Elliot, Anna, Emery, Paul, Evans, David M., Evans, Gareth, Eyre, Steve, Farmer, Anne, I, Ferrier, Nicol, Flynn, Edward, Forbes, Alistair, Forty, Liz, Franklyn, Jayne A., Frayling, Timothy M., Freathy, Rachel M., Giannoulatou, Eleni, Gibbs, Polly, Gilbert, Paul, Gordon-Smith, Katherine, Gray, Emma, Green, Elaine, Groves, Chris J., Grozeva, Detelina, Gwilliam, Rhian, Hall, Anita, Hammond, Naomi, Hardy, Matt, Harrison, Pile, Hassanali, Neelam, Hebaishi, Husam, Hines, Sarah, Hinks, Anne, Hitman, Graham A., Hocking, Lynne, Holmes, Chris, Howard, Eleanor, Howard, Philip, Howson, Joanna M.M., Hughes, Debbie, Hunt, Sarah, Isaacs, John D., Jain, Mahim, Jewell, Derek P., Johnson, Toby, Jolley, Jennifer D., Jones, Ian R., Jones, Lisa A., Kirov, George, Langford, Cordelia F., Lango-Allen, Hana, Lathrop, G. Mark, Lee, James, Lee, Kate L., Lees, Charlie, Lewis, Kevin, Lindgren, Cecilia M., Maisuria-Armer, Meeta, Maller, Julian, Mansfield, John, Marchini, Jonathan L., Martin, Paul, Massey, Dunecan C.O., McArdle, Wendy L., McGuffin, Peter, McLay, Kirsten E., McVean, Gil, Mentzer, Alex, Mimmack, Michael L., Morgan, Ann E., Morris, Andrew P., Mowat, Craig, Munroe, Patricia B., Myers, Simon, Newman, William, Nimmo, Elaine R., O’Donovan, Michael C., Onipinla, Abiodun, Ovington, Nigel R., Owen, Michael J., Palin, Kimmo, Palotie, Aarno, Parnell, Kirstie, Pearson, Richard, Pernet, David, Perry, John R.B., Phillips, Anne, Plagnol, Vincent, Prescott, Natalie J., Prokopenko, Inga, Quail, Michael A., Rafelt, Suzanne, Rayner, Nigel W., Reid, David M., Renwick, Anthony, Ring, Susan M., Robertson, Neil, Robson, Samuel, Russell, Ellie, St Clair, David, Sambrook, Jennifer G., Sanderson, Jeremy D., Sawcer, Stephen J., Schuilenburg, Helen, Scott, Carol E., Scott, Richard, Seal, Sheila, Shaw-Hawkins, Sue, Shields, Beverley M., Simmonds, Matthew J., Smyth, Debbie J., Somaskantharajah, Elilan, Spanova, Katarina, Steer, Sophia, Stephens, Jonathan, Stevens, Helen E., Stirrups, Kathy, Stone, Millicent A., Strachan, David P., Su, Zhan, Symmons, Deborah P.M., Thompson, John R., Thomson, Wendy, Tobin, Martin D., Travers, Mary E., Turnbull, Clare, Vukcevic, Damjan, Wain, Louise V., Walker, Mark, Walker, Neil M., Wallace, Chris, Warren-Perry, Margaret, Watkins, Nicholas A., Webster, John, Weedon, Michael N., Wilson, Anthony G., Woodburn, Matthew, Wordsworth, B. Paul, Yau, Chris, Young, Allan H., Zeggini, Eleftheria, Brown, Matthew A., Burton, Paul R., Caulfield, Mark J., Compston, Alastair, Farrall, Martin, Gough, Stephen C.L., Hall, Alistair S., Hattersley, Andrew T., Hill, Adrian V.S., Mathew, Christopher G., Pembrey, Marcus, Satsangi, Jack, Stratton, Michael R., Worthington, Jane, Hurles, Matthew E., Duncanson, Audrey, Ouwehand, Willem H., Parkes, Miles, Rahman, Nazneen, Todd, John A., Samani, Nilesh J., Kwiatkowski, Dominic P., McCarthy, Mark I., Craddock, Nick, Deloukas, Panos, Donnelly, Peter, Blackwell, Jenefer M., Bramon, Elvira, Casas, Juan P., Corvin, Aiden, Jankowski, Janusz, Markus, Hugh S., Palmer, Colin N.A., Plomin, Robert, Rautanen, Anna, Trembath, Richard C., Viswanathan, Ananth C., Wood, Nicholas W., Spencer, Chris C.A., Band, Gavin, Bellenguez, Céline, Freeman, Colin, Hellenthal, Garrett, Pirinen, Matti, Strange, Amy, Blackburn, Hannah, Bumpstead, Suzannah J., Dronov, Serge, Gillman, Matthew, Jayakumar, Alagurevathi, McCann, Owen T., Liddle, Jennifer, Potter, Simon C., Ravindrarajah, Radhi, Ricketts, Michelle, Waller, Matthew, Weston, Paul, Widaa, Sara, Whittaker, Pamela, Bodea, Corneliu A., Neale, Benjamin M., Ripke, Stephan, Devlin, Bernie, and Roeder, Kathryn

Published
2016
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73. Relational Ways of Being an Educator: Trauma-Informed Practice Supporting Disenfranchised Young People

Author

Morgan, Ann, Pendergast, Donna, Brown, Raymond, and Heck, Deborah

Abstract

Despite complex reasons for disengagement and exclusion from conventional schooling, all children have a right to education that is of a high quality. Disenfranchised young people require alternatives for re-engaging in education. This necessitates a rethinking of what it means to be an educator in alternative education settings and how to relate to young people who have experienced exclusion and failure in conventional school settings. Relational ways of being an educator are vital to support the creation of lifelong learners, not merely school completers. Flexible learning programmes offer a model of re-engagement in which relational ways of being an educator are prioritised. This article explores key aspects of trauma-informed practice and relational pedagogy in a network of flexi schools in Australia. Relational pedagogy can redress the impact of trauma and social exclusion experienced by young people. In flexi schools educator identities are challenged and changed by a willingness to explore and understand the impact of trauma on young people's development and capacity to learn. A commitment to trauma-informed practice and relational pedagogy requires educator identities to be co-constructed and negotiated in relationship with young people and colleagues. These shifts in educators' sense of identity in the flexi schools context are explored.

Published
2015
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79. Data from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Author

Howard, Thomas P., primary, Arnoff, Taylor E., primary, Song, Melinda R., primary, Giacomelli, Andrew O., primary, Wang, Xiaofeng, primary, Hong, Andrew L., primary, Dharia, Neekesh V., primary, Wang, Su, primary, Vazquez, Francisca, primary, Pham, Minh-Tam, primary, Morgan, Ann M., primary, Wachter, Franziska, primary, Bird, Gregory H., primary, Kugener, Guillaume, primary, Oberlick, Elaine M., primary, Rees, Matthew G., primary, Tiv, Hong L., primary, Hwang, Justin H., primary, Walsh, Katherine H., primary, Cook, April, primary, Krill-Burger, John M., primary, Tsherniak, Aviad, primary, Gokhale, Prafulla C., primary, Park, Peter J., primary, Stegmaier, Kimberly, primary, Walensky, Loren D., primary, Hahn, William C., primary, and Roberts, Charles W.M., primary

Published
2023
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80. Supplementary Figures S1-S7 from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Author

Howard, Thomas P., primary, Arnoff, Taylor E., primary, Song, Melinda R., primary, Giacomelli, Andrew O., primary, Wang, Xiaofeng, primary, Hong, Andrew L., primary, Dharia, Neekesh V., primary, Wang, Su, primary, Vazquez, Francisca, primary, Pham, Minh-Tam, primary, Morgan, Ann M., primary, Wachter, Franziska, primary, Bird, Gregory H., primary, Kugener, Guillaume, primary, Oberlick, Elaine M., primary, Rees, Matthew G., primary, Tiv, Hong L., primary, Hwang, Justin H., primary, Walsh, Katherine H., primary, Cook, April, primary, Krill-Burger, John M., primary, Tsherniak, Aviad, primary, Gokhale, Prafulla C., primary, Park, Peter J., primary, Stegmaier, Kimberly, primary, Walensky, Loren D., primary, Hahn, William C., primary, and Roberts, Charles W.M., primary

Published
2023
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81. Supplementary Tables S1-S7 from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Author

Howard, Thomas P., primary, Arnoff, Taylor E., primary, Song, Melinda R., primary, Giacomelli, Andrew O., primary, Wang, Xiaofeng, primary, Hong, Andrew L., primary, Dharia, Neekesh V., primary, Wang, Su, primary, Vazquez, Francisca, primary, Pham, Minh-Tam, primary, Morgan, Ann M., primary, Wachter, Franziska, primary, Bird, Gregory H., primary, Kugener, Guillaume, primary, Oberlick, Elaine M., primary, Rees, Matthew G., primary, Tiv, Hong L., primary, Hwang, Justin H., primary, Walsh, Katherine H., primary, Cook, April, primary, Krill-Burger, John M., primary, Tsherniak, Aviad, primary, Gokhale, Prafulla C., primary, Park, Peter J., primary, Stegmaier, Kimberly, primary, Walensky, Loren D., primary, Hahn, William C., primary, and Roberts, Charles W.M., primary

Published
2023
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82. Supplementary Methods on Data Analysis from MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

Author

Howard, Thomas P., primary, Arnoff, Taylor E., primary, Song, Melinda R., primary, Giacomelli, Andrew O., primary, Wang, Xiaofeng, primary, Hong, Andrew L., primary, Dharia, Neekesh V., primary, Wang, Su, primary, Vazquez, Francisca, primary, Pham, Minh-Tam, primary, Morgan, Ann M., primary, Wachter, Franziska, primary, Bird, Gregory H., primary, Kugener, Guillaume, primary, Oberlick, Elaine M., primary, Rees, Matthew G., primary, Tiv, Hong L., primary, Hwang, Justin H., primary, Walsh, Katherine H., primary, Cook, April, primary, Krill-Burger, John M., primary, Tsherniak, Aviad, primary, Gokhale, Prafulla C., primary, Park, Peter J., primary, Stegmaier, Kimberly, primary, Walensky, Loren D., primary, Hahn, William C., primary, and Roberts, Charles W.M., primary

Published
2023
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84. Pre-treatment calprotectin (MRP8/14) provides no added value to testing CRP alone in terms of predicting response to TNF inhibitors in rheumatoid arthritis in a post hoc analysis

Author

Smith, Samantha Louise, primary, Alexander, Sheree, additional, Nair, Nisha, additional, Viatte, Sebastien, additional, Eyre, Stephen, additional, Hyrich, Kimme L, additional, Morgan, Ann W, additional, Wilson, Anthony G, additional, Isaacs, John D, additional, Plant, Darren, additional, and Barton, Anne, additional

Published
2023
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85. Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing

Author

Ortiz-Fernández, Lourdes, primary, Carmona, Elio G, additional, Kerick, Martin, additional, Lyons, Paul, additional, Carmona, Francisco David, additional, López Mejías, Raquel, additional, Khor, Chiea Chuen, additional, Grayson, Peter C, additional, Tombetti, Enrico, additional, Jiang, Lindi, additional, Direskeneli, Haner, additional, Saruhan-Direskeneli, Guher, additional, Callejas-Rubio, José-Luis, additional, Vaglio, Augusto, additional, Salvarani, Carlo, additional, Hernández-Rodríguez, Jose, additional, Cid, Maria Cinta, additional, Morgan, Ann W, additional, Merkel, Peter A, additional, Burgner, David, additional, Smith, Kenneth GC, additional, Gonzalez-Gay, Miguel Angel, additional, Sawalha, Amr H, additional, Martin, Javier, additional, and Marquez, Ana, additional

Published
2023
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86. An Automated Method for Artifical Intelligence Assisted Diagnosis of Active Aortitis Using Radiomic Analysis of FDG PET-CT Images

Author

Duff, Lisa M., primary, Scarsbrook, Andrew F., additional, Ravikumar, Nishant, additional, Frood, Russell, additional, van Praagh, Gijs D., additional, Mackie, Sarah L., additional, Bailey, Marc A., additional, Tarkin, Jason M., additional, Mason, Justin C., additional, van der Geest, Kornelis S. M., additional, Slart, Riemer H. J. A., additional, Morgan, Ann W., additional, and Tsoumpas, Charalampos, additional

Published
2023
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90. A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

Author

Martínez-Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo-Conde, Ana, Madroñero-Vuelta, Ana B., Fernández-Nebro, Antonio, Ordóñez-Cañizares, M. Carmen, Escalante, Begoña, Marí-Alfonso, Begoña, Sopeña, Bernardo, Magro, César, Raya, Enrique, Grau, Elena, Román, José A., de Miguel, Eugenio, López-Longo, F. Javier, Martínez, Lina, Gómez-Vaquero, Carmen, Fernández-Gutiérrez, Benjamín, Rodríguez-Rodríguez, Luis, Díaz-López, J. Bernardino, Caminal-Montero, Luis, Martínez-Zapico, Aleida, Monfort, Jordi, Tío, Laura, Sánchez-Martín, Julio, Alegre-Sancho, Juan J., Sáez-Comet, Luis, Pérez-Conesa, Mercedes, Corbera-Bellalta, Marc, García-Villanueva, M. Jesús, Fernández-Contreras, M. Encarnación, Sanchez-Pernaute, Olga, Blanco, Ricardo, Ortego-Centeno, Norberto, Ríos-Fernández, Raquel, Callejas, José L., Fanlo-Mateo, Patricia, Martínez-Taboada, Víctor M., Carmona, F. David, Mackie, Sarah L., Martín, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castañeda, Santos, Cid, Maria C., Hernández-Rodríguez, José, Prieto-González, Sergio, Solans, Roser, Ramentol-Sintas, Marc, González-Escribano, M. Francisca, Ortiz-Fernández, Lourdes, Morado, Inmaculada C., Narváez, Javier, Miranda-Filloy, José A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schönau, Verena, Franke, Andre, Palm, Øyvind, Molberg, Øyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg, Steven R., Gregersen, Peter K., Pease, Colin T., Gough, Andrew, Green, Michael, Hordon, Lesley, Jarrett, Stephen, Watts, Richard, Levy, Sarah, Patel, Yusuf, Kamath, Sanjeet, Dasgupta, Bhaskar, Worthington, Jane, Koeleman, Bobby P.C., de Bakker, Paul I.W., Barrett, Jennifer H., Salvarani, Carlo, Merkel, Peter A., González-Gay, Miguel A., Morgan, Ann W., and Martín, Javier

Published
2015
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91. Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing

Author

Ortiz-Fernández, Lourdes, Carmona, Elio G, Kerick, Martin, Lyons, Paul, Carmona, Francisco David, López Mejías, Raquel, Khor, Chiea Chuen, Grayson, Peter C, Tombetti, Enrico, Jiang, Lindi, Direskeneli, Haner, Saruhan-Direskeneli, Guher, Callejas-Rubio, José-Luis, Vaglio, Augusto, Salvarani, Carlo, Hernández-Rodríguez, Jose, Cid, Maria Cinta, Morgan, Ann W, Merkel, Peter A, Burgner, David, Smith, Kenneth Gc, Gonzalez-Gay, Miguel Angel, Sawalha, Amr H, Martin, Javier, Marquez, Ana, Ortiz-Fernández, Lourdes [0000-0002-0247-4280], Carmona, Francisco David [0000-0002-1427-7639], Grayson, Peter C [0000-0002-8269-9438], Salvarani, Carlo [0000-0003-3708-3148], Hernández-Rodríguez, Jose [0000-0002-2357-2015], Cid, Maria Cinta [0000-0002-4730-0938], Gonzalez-Gay, Miguel Angel [0000-0002-7924-7406], Martin, Javier [0000-0002-2202-0622], Marquez, Ana [0000-0001-9913-7688], Apollo - University of Cambridge Repository, and Ortiz-Fernandez L., Carmona E. G., Kerick M., Lyons P., Carmona F. D., Mejias R. L., Khor C. C., Grayson P. C., Tombetti E., Jiang L., et al.

Subjects
Internal Diseases, Vasculitis, Immunology, Autoimmunity, SUSCEPTIBILITY, VARIANTS, Sağlık Bilimleri, İmmünoloji ve Romatoloji, İç Hastalıkları, Clinical Medicine (MED), General Biochemistry, Genetics and Molecular Biology, Immunology and Rheumatology, ACTIVATION, Genetic, Rheumatology, Health Sciences, Humans, Immunology and Allergy, Klinik Tıp (MED), CTLA-4 Antigen, Genetic Predisposition to Disease, Polymorphism, GENOME-WIDE ASSOCIATION, ROMATOLOJİ, Internal Medicine Sciences, Polymorphism, Genetic, Klinik Tıp, Systemic Vasculitis, Drug Repositioning, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Tıp, Medicine, Romatoloji, Apoptosis Regulatory Proteins
Abstract

Objectives The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a consequence of the low prevalence of vasculitides. This study aimed to identify new genetic risk loci for the main systemic vasculitides through a comprehensive analysis of their genetic overlap. Methods Genome-wide data from 8467 patients with any of the main forms of vasculitis and 29 795 healthy controls were meta-analysed using ASSET. Pleiotropic variants were functionally annotated and linked to their target genes. Prioritised genes were queried in DrugBank to identify potentially repositionable drugs for the treatment of vasculitis. Results Sixteen variants were independently associated with two or more vasculitides, 15 of them representing new shared risk loci. Two of these pleiotropic signals, located close to CTLA4 and CPLX1, emerged as novel genetic risk loci in vasculitis. Most of these polymorphisms appeared to affect vasculitis by regulating gene expression. In this regard, for some of these common signals, potential causal genes were prioritised based on functional annotation, including CTLA4, RNF145, IL12B, IL5, IRF1, IFNGR1, PTK2B, TRIM35, EGR2 and ETS2, each of which has key roles in inflammation. In addition, drug repositioning analysis showed that several drugs, including abatacept and ustekinumab, could be potentially repurposed in the management of the analysed vasculitides. Conclusions We identified new shared risk loci with functional impact in vasculitis and pinpointed potential causal genes, some of which could represent promising targets for the treatment of vasculitis., HELICAL Innovative Training Network, European Commission funded-under the Marie Sklodowska-Curie 813545, Cooperative Research Thematic Network programme RD16/0012/0013, Redes de Investigacion Cooperativa Orientadas a Resultados en Salud (RICORS) RD21/0002/0039, Instituto de Salud Carlos III PI18/00040, Juan de la Cierva Incorporacion fellowship IJC2019- 040746-I, United States Department of Health & Human Services, National Institutes of Health (NIH) - USA, NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01 AR070148, National Health and Medical Research Council (NHMRC) of Australia GTN1175744, Victorian Government's Operational Infrastructure Support Program, Rare Diseases Clinical Research Network (RDCRN), initiative of the Office of Rare Diseases Research (ORDR), NIH National Center for Advancing Translational Sciences (NCATS), NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) U54 AR057319, NIH National Center for Research Resources (NCRR) U54 RR019497

Published
2023

92. Dose-dependent oral glucocorticoid cardiovascular risks in people with immune-mediated inflammatory diseases: A population-based cohort study

Author

Pujades-Rodriguez, Mar, Morgan, Ann W., Cubbon, Richard M., and Wu, Jianhua

Subjects
Corticosteroids -- Usage -- Complications and side effects, Inflammatory bowel diseases -- Drug therapy, Cardiovascular diseases -- Risk factors, Autoimmune diseases -- Drug therapy, Biological sciences
Abstract

Background Glucocorticoids are widely used to reduce disease activity and inflammation in patients with a range of immune-mediated inflammatory diseases. It is uncertain whether or not low to moderate glucocorticoid dose increases cardiovascular risk. We aimed to quantify glucocorticoid dose-dependent cardiovascular risk in people with 6 immune-mediated inflammatory diseases. Methods and findings We conducted a population-based cohort analysis of medical records from 389 primary care practices contributing data to the United Kingdom Clinical Practice Research Datalink (CPRD), linked to hospital admissions and deaths in 1998-2017. We estimated time-variant daily and cumulative glucocorticoid prednisolone-equivalent dose-related risks and hazard ratios (HRs) of first all-cause and type-specific cardiovascular diseases (CVDs). There were 87,794 patients with giant cell arteritis and/or polymyalgia rheumatica (n = 25,581), inflammatory bowel disease (n = 27,739), rheumatoid arthritis (n = 25,324), systemic lupus erythematosus (n = 3,951), and/or vasculitis (n = 5,199), and no prior CVD. Mean age was 56 years and 34.1% were men. The median follow-up time was 5.0 years, and the proportions of person-years spent at each level of glucocorticoid daily exposure were 80% for non-use, 6.0% for Incident CVD occurred in 13,426 (15.3%) people, including 6,013 atrial fibrillation, 7,727 heart failure, and 2,809 acute myocardial infarction events. One-year cumulative risks of all-cause CVD increased from 1.4% in periods of non-use to 8.9% for a daily prednisolone-equivalent dose of [greater than or equal to]25.0 mg. Five-year cumulative risks increased from 7.1% to 28.0%, respectively. Compared to periods of non-glucocorticoid use, those with The lack of hospital medication records and drug adherence data might have led to underestimation of the dose prescribed when specialists provided care and overestimation of the dose taken during periods of low disease activity. The resulting dose misclassification in some patients is likely to have reduced the size of dose-response estimates. Conclusions In this study, we observed an increased risk of CVDs associated with glucocorticoid dose intake even at lower doses (, Author(s): Mar Pujades-Rodriguez 1,*, Ann W. Morgan 2,3, Richard M. Cubbon 2, Jianhua Wu 4 Introduction Patients with immune-mediated inflammatory diseases often receive courses of oral glucocorticoids to reduce disease [...]

Published
2020
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95. Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunity

Author

Robinson, James I, Md Yusof, Md Yuzaiful, Davies, Vinny, Wild, Dawn, Morgan, Michael, Taylor, John C, El-Sherbiny, Yasser, Morris, David L, Liu, Lu, Rawstron, Andy C, Buch, Maya H, Plant, Darren, Cordell, Heather J, Isaacs, John D, Bruce, Ian N, Emery, Paul, Barton, Anne, Vyse, Timothy J, Barrett, Jennifer H, Vital, Edward M, Morgan, Ann W, MATURA Consortia, MASTERPLANS Consortia, El-Sherbiny, Yasser [0000-0003-4791-3475], and Apollo - University of Cambridge Repository

Subjects
DNA Copy Number Variations, Genotype, Autoimmune diseases, Receptors, IgG, Autoimmunity, Arthritis, Rheumatoid, Systemic lupus erythematosus, FOS: Biological sciences, B-lymphocytes, Genetics, Humans, Lupus Erythematosus, Systemic, Longitudinal Studies, Rheumatoid arthritis, Rituximab
Abstract

BACKGROUND: Rituximab is widely used to treat autoimmunity but clinical response varies. Efficacy is determined by the efficiency of B-cell depletion, which may depend on various Fc gamma receptor (FcγR)-dependent mechanisms. Study of FcγR is challenging due to the complexity of the FCGR genetic locus. We sought to assess the effect of FCGR variants on clinical response, B-cell depletion and NK-cell-mediated killing in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). METHODS: A longitudinal cohort study was conducted in 835 patients [RA = 573; SLE = 262]. Clinical outcome measures were two-component disease activity score in 28-joints (2C-DAS28CRP) for RA and British Isles Lupus Assessment Group (BILAG)-2004 major clinical response (MCR) for SLE at 6 months. B-cells were evaluated by highly-sensitive flow cytometry. Single nucleotide polymorphism and copy number variation for genes encoding five FcγRs were measured using multiplex ligation-dependent probe amplification. Ex vivo studies assessed NK-cell antibody-dependent cellular cytotoxicity (ADCC) and FcγR expression. FINDINGS: In RA, carriage of FCGR3A-158V and increased FCGR3A-158V copies were associated with greater 2C-DAS28CRP response (adjusted for baseline 2C-DAS28CRP). In SLE, MCR was associated with increased FCGR3A-158V, OR 1.64 (95% CI 1.12-2.41) and FCGR2C-ORF OR 1.93 (95% CI 1.09-3.40) copies. 236/413 (57%) patients with B-cell data achieved complete depletion. Homozygosity for FCGR3A-158V and increased FCGR3A-158V copies were associated with complete depletion in combined analyses. FCGR3A genotype was associated with rituximab-induced ADCC, and increased NK-cell FcγRIIIa expression was associated with improved clinical response and depletion in vivo. Furthermore, disease status and concomitant therapies impacted both NK-cell FcγRIIIa expression and ADCC. INTERPRETATION: FcγRIIIa is the major low affinity FcγR associated with rituximab response. Increased copies of the FCGR3A-158V allele (higher affinity for IgG1), influences clinical and biological responses to rituximab in autoimmunity. Enhancing FcγR-effector functions could improve the next generation of CD20-depleting therapies and genotyping may stratify patients for optimal treatment protocols. FUNDING: Medical Research Council, National Institute for Health and Care Research, Versus Arthritis.

Published
2022

96. Top Ten Tips Palliative Care Clinicians Should Know About Navigating the Needs of Adults with Intellectual Disabilities

Author

Moore, Caitlyn M., primary, Pan, Cynthia X., additional, Roseman, Karin, additional, Stephens, Mary M., additional, Bien-Aime, Casey, additional, Morgan, Ann C., additional, Ross, Wendy, additional, Castillo, Matthew C., additional, Palathra, Brigit C., additional, Jones, Christopher A., additional, Ailey, Sarah, additional, Tuffrey-Wijne, Irene, additional, Smeltzer, Suzanne C., additional, and Tobias, Jane, additional

Published
2022
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97. Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

Author

Fielding, Ceri A., Jones, Gareth W., McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S., Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D., Williams, Geraint T., Davies, Simon J., Humphreys, Ian R., O’Donnell, Valerie B., Taylor, Philip R., Jenkins, Brendan J., Topley, Nicholas, and Jones, Simon A.

Published
2014
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99. Developing a Profiling Tool Using a Values Approach to School Renewal

Author

Brown, Raymond, Heck, Deborah, Pendergast, Donna, Kanasa, Harry, and Morgan, Ann

Abstract

Purpose: The purpose of this article is to outline the evidence-based development of a learning approach to school renewal that employs information from key members of a school community (teachers, parents, students) to promote school-based discussions about school renewal. Setting: The study took place in an independent system of Catholic schools. Schools in this tradition have an enduring history in the development of Catholic education and have partner schools in Australia, New Zealand, Papua New Guinea, India, Africa, Europe, and the Americas. Research Design: The study employed a qualitative sociocultural design focused on generating narratives that could be used to describe the school as a community of practice and the development of a valid and reliable School Renewal Profiling Tool (SRPT) that provides an empirical picture of a school's culture and practice. Data Collection and Analysis: Data collection included school visitations, classroom observations, in-depth interviews, and publicly available school documentation and data gathered from a case study site, a coeducational secondary college located in the center of a metropolitan city. Data collected were subjected to thematic analysis and principal components analysis (PCA). Data gathered from the SRPT items were then presented to the school community in the form of a collated report for feedback and school renewal purposes. Findings: Findings suggest that the SRPT has the potential to capture local ways of knowing and doing as resources to promote organizational school renewal through reflecting individual perceptions of participation in collective practice. Conclusions: The research surrounding the development of the SRPT contributes to the field of school renewal in two distinct ways. First, the development of the SRPT offers an approach to school renewal that focuses on the values upon which a school community is based. Second, the SRPT avoids the difficulty of what Fielding (2004) refers to as "speaking about and for others," where the original thoughts of respondents are couched in the language and values of the researcher.

Published
2018

100. Nurse Practitioner Lead Pediatric Baclofen Pump Program: Impact on Safety and Quality of Care

Author

Buxton, Kristin, Morgan, Ann, and Rogers, Jayne

Subjects
Patients -- Care and treatment, Injections, Spinal -- Dosage and administration -- Analysis, Health care industry
Abstract

Children with cerebral palsy experience spasticity that can be debilitating and cause significant pain and contractures. Intrathecal baclofen (ITB) therapy can help relieve this spasticity and improve the quality of life for these patients, but it comes with risk. Withdrawal from the medication in case of abrupt discontinuation of delivery can be life-threatening. Regular maintenance of the system is mandatory. Having a program in place to manage the device and support patients helps to ensure their safety. Toward this end, we developed a program with a nurse practitioner (NP) leader to secure the safety and quality of care for patients using ITB therapy. As the program grew, the NP role as an expert in the care and management of ITB pumps became essential to the safety and care of these patients. In addition to the basic outpatient and inpatient management of the baclofen pump, the NP developed a detailed educational program for the patients and leads the quality and safety initiative for the program. The NP is also in a unique position to have intimate knowledge of the patient's condition and build a strong relationship with the patient/family. The NP is able to use this knowledge and relationship as concerns arise that could be related to the ITB therapy. This has greatly improved the safety and quality of care for patients using ITB therapy at our institution. Keywords: advance practice nurse, baclofen pump, intrathecal, pain management, pediatrics, Intrathecal baclofen (ITB) therapy is a treatment option used to manage severe spasticity of cerebral or spinal origin via an implantable infusion system. The implanted pump delivers precise amounts of [...]

Published
2017
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