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255 results on '"Moore, Ronald B."'

57. ASSOCIATION BETWEEN COMORBIDITY AND SURVIVAL AFTER RADICAL CYSTECTOMY: RESULTS FROM THE ALBERTA UROLOGY INSTITUTE RADICAL CYSTECTOMY DATABASE

Author

Fairey, Adrian S, primary, Jacobsen, Niels-Erik B, additional, Chetner, Michael P, additional, Mador, David R, additional, Metcalfe, James B, additional, Moore, Ronald B, additional, Rourke, Keith F, additional, Todd, Gerald T, additional, Venner, Peter M, additional, Voaklander, Don C, additional, and Estey, Eric P, additional

Published
2009
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61. Monitoring photodynamic therapy with photoacoustic microscopy.

Author

Peng Shao, Chapman, David W., Moore, Ronald B., and Zemp, Roger J.

Subjects
PHOTODYNAMIC therapy, BLOOD vessels, ACOUSTIC imaging, PHOTOSENSITIZERS, TREATMENT effectiveness
Abstract

We present our work on examining the feasibility of monitoring photodynamic therapy (PDT)-induced vasculature change with acoustic-resolution photoacoustic microscopy (PAM). Verteporfin, an FDA-approved photosensitizer for clinical PDT, was utilized. With a 60-μm-resolution PAM system, we demonstrated the capability of PAM to monitor PDT-induced vasculature variations in a chick chorioallantoic membrane model with topical application and in a rat ear with intravenous injection of the photosensitizer. We also showed oxygen saturation change in target blood vessels due to PDT. Success of the present approach may potentially lead to the application of PAM imaging in evaluating PDT efficacy, guiding treatment, and predicting responders from nonresponders. [ABSTRACT FROM AUTHOR]

Published
2015
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78. Preclinical Assessment of Hypocrellin B and Hypocrellin B Derivatives as Sensitizers for Photodynamic Therapy of Cancer: Progress Update

Author

Miller, Gerald G., primary, Brown, Kevin, additional, Ballangrud, Åse M., additional, Barajas, Oscar, additional, Xiao, Z., additional, Tulip, John, additional, Lown, J. William, additional, Leithoff, Jacqueline M., additional, Allalunis-Turner, M. Joan, additional, Mehta, Ram D., additional, and Moore, Ronald B., additional

Published
1997
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85. UPTAKE KINETICS AND INTRACELLULAR LOCALIZATION OF HYPOCRELLIN PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY: A CONFOCAL MICROSCOPY STUDY

Author

Miller, Gerald G., primary, Brown, Kevin, additional, Moore, Ronald B., additional, McPhee, Malcolm S., additional, Diwu, Zhenjun J., additional, Liu, Jixiang, additional, Huang, Liren, additional, Lown, J. William, additional, Begg, David A., additional, Chlumecky, Vera, additional, and Tulip, John, additional

Published
1995
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95. Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy

Author

Miller, Gerald G., Brown, Kevin, Moore, Ronald B., Diwu, Zhenjun, Liu, Jixiang, Huang, Liren, Lown, J. W., Begg, David A., Chlumecky, Vera, Tulip, John, and McPhee, Malcolm S.

Abstract

Hypocrellins are naturally occurring compounds with photosensitizing properties in biological systems. We have prepared synthetic derivatives of hypocrellin B, which have promise as photosensitizers in the clinical application of photodynamic therapy. The inherent fluorescence of four selected compounds has provided a means of determining their uptake and distribution in monolayer cultures of EMT6/Ed murine tumor cells, via fluorescence confocal microscopy.

Published
1994
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96. Urothelial conversion of 5-aminolevulinic acid to protoporphyrin IX following oral or intravesical administration

Author

Moore, Ronald B., Miller, Gerald G., Brown, Kevin, Bhatnagar, Rakesh, Tulip, John, and McPhee, Malcolm S.

Abstract

Preferential conversion of 5-aminolevulinic acid (5-ALA) to protoporphyrin-IX (Pp-IX) occurs in malignant tissue, with accumulation to diagnostic and therapeutic levels. Recent studies have suggested selective conversion in epithelial tissue following oral or intravenous administration. Topical application avoids systemic photosensitization. However, the glycosaminoglycan (GAG) layer lining the urinary bladder is believed to be a protective barrier generally limiting mucosal absorption. Our objective was to evaluate uptake and conversion of 5-ALA following intravesical or oral administration. Using a rat model, Pp-IX content within epithelial and muscularis layers was quantitated by fluorescence confocal microscopy. Following intravesical administration, Pp-IX accumulated predominantly in the urothelium; whereas following oral administration, Pp-IX accumulated in both the urothelium and muscularis. Intravesical 5-ALA administration is feasible and may afford selective photosensitization of the urothelium for treatment of carcinoma in situ.

Published
1994
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97. Light distribution and optical coefficients in prostate tumor

Author

Ballangrud, Ase M., Wilson, P. J., Miller, Gerald G., Moore, Ronald B., McPhee, Malcolm S., and Tulip, John

Abstract

Treatment of a solid tumor with photodynamic therapy (PDT) requires interstitial illumination, since the penetration depth of visible light in tissue is limited. Accurate light dosimetry in solid tumors requires the use of a mathematical model describing light propagation in tissue. By comparing the modeled fluence with measurements of fluence in tissue, the optical coefficients of the tissue can be found. We prefer to use a flat cleaved probe for measurements of the fluence in tissue instead of a spherical probe. In comparing the results of the model to the experimental data, we must deal with the fact that the model gives us the radiant fluence, while the experimental data is the power measured by the flat cleaved fiber with non-isotropic response. Measurements of the angular fluence in a tissue phantom show that the degree of anisotropy in angular fluence decreases with increasing distance from the source. The same result is found in chicken muscle. A calibration factor which modifies the measurements of fluence with a flat cleaved probe to account for the change in anisotropy in the angular fluence is presented.

Published
1994
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98. Readers report.

Author

Johnston, Fred, Sanderson, T. H., Deaver, D. H., Merin, Kenneth, Moore, Ronald B., Cramer, Kenneth R., Blitz, Herbert John, Bazarian, Carl J., Rhoden, A. E., and Carter, Warren H.

Subjects
LETTERS to the editor, TAX returns, EDUCATIONAL finance, TAX refunds
Abstract

Several letters to the editor are presented in response to articles published in earlier issues including "MIT makes a bad compromise" published in November 22, 1969 issue, "ECO's computer printout is still a blank" published in the same issue and "Squeezing even more out of tax returns" published in December 6, 1969 issue.

Published
1969

99. Readers report.

Author

Smith, Raymond D., Wall, William E., Brown, G. P., Schaffner, Leon C., Follett, Dwight W., Moore, Ronald B., and Welshofer, Helen C.

Subjects
LETTERS to the editor, CLEAN energy investment, TAX reform
Abstract

Several letters to the editor are presented in response to articles in previous issues including "Con Ed runs out of Clean Energy" in the August 16, 1969 issue, "The New York phone hang up" in the August 2, 1969 issue and "What real tax reform would mean" in the August 2, 1969 issue.

Published
1969

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