1,214 results on '"Mondello, P"'
Search Results
52. Hidden threat lurking in extensive hand hygiene during the Covid-19 pandemic: investigation of sensitizing molecules in gel products by hyphenated chromatography techniques
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Salerno, Tania M. G., Trovato, Emanuela, Cafeo, Giovanna, Vento, Federica, Zoccali, Mariosimone, Donato, Paola, Dugo, Paola, and Mondello, Luigi
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- 2023
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53. RE-MIND2: comparative effectiveness of tafasitamab plus lenalidomide versus polatuzumab vedotin/bendamustine/rituximab (pola-BR), CAR-T therapies, and lenalidomide/rituximab (R2) based on real-world data in patients with relapsed/refractory diffuse large B-cell lymphoma
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Nowakowski, Grzegorz S., Yoon, Dok Hyun, Mondello, Patrizia, Joffe, Erel, Peters, Anthea, Fleury, Isabelle, Greil, Richard, Ku, Matthew, Marks, Reinhard, Kim, Kibum, Zinzani, Pier Luigi, Trotman, Judith, Sabatelli, Lorenzo, Waltl, Eva E., Winderlich, Mark, Sporchia, Andrea, Kurukulasuriya, Nuwan C., Cordoba, Raul, Hess, Georg, and Salles, Gilles
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- 2023
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54. A miniaturized comprehensive approach for total lipidome analysis and vitamin D metabolite quantification in human serum
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Donnarumma, Danilo, Arena, Alessia, Trovato, Emanuela, Rigano, Francesca, Zoccali, Mariosimone, and Mondello, Luigi
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- 2023
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55. Solid-phase microextraction Arrow combined with comprehensive two-dimensional gas chromatography–mass spectrometry for the elucidation of the volatile composition of honey samples
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Manousi, Natalia, Kalogiouri, Natasa, Ferracane, Antonio, Zachariadis, George A., Samanidou, Victoria F., Tranchida, Peter Q., Mondello, Luigi, and Rosenberg, Erwin
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- 2023
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56. A method for the determination of 70 pesticides in extra virgin olive oil based on a limited-volume solvent extraction step prior to comprehensive two-dimensional gas chromatography-tandem mass spectrometry
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Arena, Alessia, Zoccali, Mariosimone, Mondello, Luigi, and Tranchida, Peter Q.
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- 2023
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57. Determination of the polyphenolic content of berry juices using focusing-modulated comprehensive two-dimensional liquid chromatography coupled to mass spectrometry detection
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Arena, Katia, Cacciola, Francesco, Miceli, Natalizia, Taviano, Maria Fernanda, Cavò, Emilia, Murphy, Robert E., Dugo, Paola, and Mondello, Luigi
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- 2023
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58. An upper bound on the revised first Betti number and a torus stability result for RCD spaces
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Mondello, Ilaria, Mondino, Andrea, and Perales, Raquel
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Mathematics - Differential Geometry ,Mathematics - Metric Geometry - Abstract
We prove an upper bound on the rank of the abelianised revised fundamental group (called "revised first Betti number") of a compact $RCD^{*}(K,N)$ space, in the same spirit of the celebrated Gromov-Gallot upper bound on the first Betti number for a smooth compact Riemannian manifold with Ricci curvature bounded below. When the synthetic lower Ricci bound is close enough to (negative) zero and the aforementioned upper bound on the revised first Betti number is saturated (i.e. equal to the integer part of $N$, denoted by $\lfloor N \rfloor$), then we establish a torus stability result stating that the space is $\lfloor N \rfloor$-rectifiable as a metric measure space, and a finite cover must be mGH-close to an $\lfloor N \rfloor$-dimensional flat torus; moreover, in case $N$ is an integer, we prove that the space itself is bi-H\"older homeomorphic to a flat torus. This second result extends to the class of non-smooth $RCD^{*}(-\delta, N)$ spaces a celebrated torus stability theorem by Colding (later refined by Cheeger-Colding)., Comment: 38 pages. Final version, to appear in Commentarii Mathematici Helvetici
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- 2021
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59. Limits of manifolds with a Kato bound on the Ricci curvature
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Carron, Gilles, Mondello, Ilaria, and Tewodrose, David
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Mathematics - Differential Geometry - Abstract
We study the structure of Gromov-Hausdorff limits of sequences of Riemannian manifolds $\{(M_\alpha^n,g_\alpha)\}_{\alpha \in A}$ whose Ricci curvature satisfies a uniform Kato bound. We first obtain Mosco convergence of the Dirichlet energies to the Cheeger energy and show that tangent cones of such limits satisfy the $\mathrm{RCD}(0,n)$ condition. When assuming a non-collapsing assumption, we introduce a new family of monotone quantities, which allows us to prove that tangent cones are also metric cones. We then show the existence of a well-defined stratification in terms of splittings of tangent cones. We finally prove volume convergence to the Hausdorff $n$-measure.
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- 2021
60. Potential Role of mRNA in Estimating Postmortem Interval: A Systematic Review
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Vincenzo Cianci, Cristina Mondello, Daniela Sapienza, Maria Cristina Guerrera, Alessio Cianci, Annalisa Cracò, Fausto Omero, Vittorio Gioffrè, Patrizia Gualniera, Alessio Asmundo, and Antonino Germanà
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PMI estimation ,postmortem interval estimation ,RNA degradation ,mRNA degradation ,forensic pathology ,forensic sciences ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Although the postmortem interval estimation still represents one of the main goals of forensic medicine, there are still several limitations that weigh on the methods most used for its determination: for this reason, even today, precisely estimating the postmortem interval remains one of the most important challenges in the forensic pathology field. To try to overcome these limitations, in recent years, numerous studies have been conducted on the potential use of the mRNA degradation time for reaching a more precise post mortem interval (PMI) estimation. An evidence-based systematic review of the literature has been conducted to evaluate the state of the art of the knowledge focusing on the potential correlation between mRNA degradation and PMI estimation. The research has been performed using the electronic databases PubMed and Scopus. The analysis conducted made it possible to confirm the potential applicability of mRNA for reaching a more precise PMI estimation. The analysis of the results highlighted the usefulness of some mRNAs, such as β-actin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA, especially in short time frames, within a few hours or days of death. The matrices on which these analyses were conducted were also analyzed, resulting in less exposure to the external environment, including the heart, brain, and dental pulp. The major limitations were also reported, including the short time intervals analyzed in most of the articles, the lack of mathematical models, and the failure to report the error rate between the mRNA degradation time and PMI. Given the still small number of published articles, the lack of globally recognized standardized methods, and the numerous techniques used to evaluate the mRNA degradation times, numerous and larger studies are still necessary to reach more solid and shared evidence.
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- 2024
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61. Aromatic Characterisation of Moscato Giallo by GC-MS/MS and Validation of Stable Isotopic Ratio Analysis of the Major Volatile Compounds
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Mauro Paolini, Alberto Roncone, Lorenzo Cucinotta, Danilo Sciarrone, Luigi Mondello, Federica Camin, Sergio Moser, Roberto Larcher, and Luana Bontempo
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Moscato Giallo ,volatile compounds ,GC-MS/MS ,GC-C/Py-IRMS ,Microbiology ,QR1-502 - Abstract
Among the Moscato grapes, Moscato Giallo is a winegrape variety characterised by a high content of free and glycosylated monoterpenoids, which gives wines very intense notes of ripe fruit and flowers. The aromatic bouquet of Moscato Giallo is strongly influenced by the high concentration of linalool, geraniol, linalool oxides, limonene, α-terpineol, citronellol, hotrienol, diendiols, trans/cis-8-hydroxy linalool, geranic acid and myrcene, that give citrus, rose, and peach notes. Except for quali-quantitative analysis, no investigations regarding the isotopic values of the target volatile compounds in grapes and wines are documented in the literature. Nevertheless, the analysis of the stable isotope ratio represents a modern and powerful tool used by the laboratories responsible for official consumer protection, for food quality and genuineness assessment. To this aim, the aromatic compounds extracted from grapes and wine were analysed both by GC-MS/MS, to define the aroma profiles, and by GC-C/Py-IRMS, for a preliminary isotope compound-specific investigation. Seventeen samples of Moscato Giallo grapes were collected during the harvest season in 2021 from two Italian regions renowned for the cultivation of this aromatic variety, Trentino Alto Adige and Veneto, and the corresponding wines were produced at micro-winery scale. The GC-MS/MS analysis confirmed the presence of the typical terpenoids both in glycosylated and free forms, responsible for the characteristic aroma of the Moscato Giallo variety, while the compound-specific isotope ratio analysis allowed us to determine the carbon (δ13C) and hydrogen (δ2H) isotopic signatures of the major volatile compounds for the first time.
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- 2024
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62. Fatal Outcome Due to Kounis Syndrome Following Fluorescein Retinal Angiography: A Case Report
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Vincenzo Cianci, Claudia Pitrone, Daniela Sapienza, Alessandro Meduri, Antonio Ieni, Patrizia Gualniera, Alessio Asmundo, and Cristina Mondello
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Kounis syndrome ,anaphylaxis ,myocardial ischemia ,forensic pathology ,post mortem biochemistry ,post mortem immunohistochemistry ,Medicine (General) ,R5-920 - Abstract
Kounis Syndrome (KS) is a clinical entity triggered by allergic or hypersensitivity reactions capable of inducing acute coronary events. Several causes can induce KS, including drugs and insect stings. Here, a rare case of post mortem assessment of fatal KS related to fluorescein retinal angiography has been reported. An 80-year-old man in follow-up for a retinal vein thrombosis underwent a retinal fluoroangiography. Approximately 30 min later, the patient complained of sweating and dizziness, and suddenly lost consciousness due to a cardiac arrest. Despite the immediate cardiopulmonary resuscitation, he died. The autopsy revealed foamy yellowish edema in the respiratory tract and coronary atherosclerosis with eccentric plaques partially obstructing the lumen. The routine histology highlighted lung emphysema and myocyte break-up with foci of contraction band necrosis at the myocardial tissue. Biochemistry showed increased serum tryptase, troponin, and p-BNP. Activated and degranulated (tryptase) mast cells were detected, using immunohistochemistry, in the larynx, lungs, spleen, and heart. Acute myocardial ischemia due to allergic coronary vasospasm related to fluorescein hypersensitivity has been assessed as cause of death. KS-related deaths are considered rare events, and the post mortem assessment of KS quite difficult. The integration of several investigations (gross and microscopic examination, biochemistry, immunohistochemistry) can provide useful findings to support the diagnosis, helping to reduce the unrecognized cases as much as possible.
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- 2024
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63. Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations
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Huie, J Russell, Mondello, Stefania, Lindsell, Christopher J, Antiga, Luca, Yuh, Esther L, Zanier, Elisa R, Masson, Serge, Rosario, Bedda L, Ferguson, Adam R, Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Bodien, Yelena, Bullock, M Ross, Chesnut, Randall, Corrigan, John D, Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, V Ramana, Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Giacino, Joseph, Goldman, Dana, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, J Claude, Hotz, Gillian, Jain, Sonia, Korley, Frederick, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Machamer, Joan, Madden, Christopher, Manley, Geoffrey T, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B, Noel, Florence, Okonkwo, David, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rosand, Jonathan, Sander, Angelle, Schnyer, David, Seabury, Seth, Stein, Murray, Taylor, Sabrina, Temkin, Nancy, Toga, Arthur, Valadka, Alex, Vassar, Mary, Vespa, Paul, Wang, Kevin, Yue, John K, Zafonte, Ross, Ackerlund, Cecilia, Adams, Hadie, Agnoletti, Vanni, Allanson, Judith, Amrein, Krisztina, Andaluz, Norberto, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antun, Azasevac, Antoni, Anna, Ardon, Hilko, Auslands, Kaspars, Azouvi, Philippe, Luisa Azzolini, Maria, Baciu, Camelia, Badenes, Rafael, Bartels, Ronald, Barzó, Pál, Bauerfeind, Ursula, Beauvais, Romuald, Beer, Ronny, Belda, Francisco Javier, Bellander, Bo Michael, Belli, Antonio, Bellier, Rémy, Benali, Habib, Benard, Thierry, Berardino, Maurizio, Beretta, Luigi, Beynon, Christopher, Bilotta, Federico, and Binder, Harald
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Traumatic Head and Spine Injury ,Traumatic Brain Injury (TBI) ,Neurosciences ,Physical Injury - Accidents and Adverse Effects ,Brain Disorders ,Injuries and accidents ,Good Health and Well Being ,Biomarkers ,Brain Injuries ,Traumatic ,Common Data Elements ,Data Interpretation ,Statistical ,Humans ,Information Dissemination ,Reference Standards ,biomarkers ,data sharing ,traumatic brain injury ,Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators ,The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators ,Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Participants and Investigators ,Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Participants and Investigators ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
Recent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics, involve vast quantities of high-throughput and high-content data. Management, curation, analysis, and evidence synthesis of these data are not trivial tasks. In this review, we discuss data management concepts and statistical and data sharing strategies when dealing with biomarker data in the context of TBI research. We propose that application of biomarkers involves three distinct steps-discovery, evaluation, and evidence synthesis. First, complex/big data has to be reduced to useful data elements at the stage of biomarker discovery. Second, inferential statistical approaches must be applied to these biomarker data elements for assessment of biomarker clinical utility and validity. Last, synthesis of relevant research is required to support practice guidelines and enable health decisions informed by the highest quality, up-to-date evidence available. We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on four major clinical projects (Transforming Research and Clinical Knowledge in TBI, Collaborative European NeuroTrauma Effectiveness Research in TBI, Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe, and Approaches and Decisions in Acute Pediatric TBI Trial), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities, and challenges, as well as examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision medicine in TBI.
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- 2021
64. Correction: High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI
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Rezoagli, Emanuele, Petrosino, Matteo, Rebora, Paola, Menon, David K., Mondello, Stefania, Cooper, D. James, Maas, Andrew I. R., Wiegers, Eveline J. A., Galimberti, Stefania, and Citerio, Giuseppe
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- 2023
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65. Olea europaea var. Oleaster a promising nutritional food with in vitro antioxidant, antiglycation, antidiabetic and antiproliferative effects
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Kabach, Imad, Bouchmaa, Najat, Ben Mrid, Reda, Zouaoui, Zakia, Maadoudi, Mohammed El, Kounnoun, Ayoub, Asraoui, Fadoua, El Mansouri, Fouad, Zyad, Abdelmajid, Cacciola, Francesco, Oulad El Majdoub, Yassine, Mondello, Luigi, and Nhiri, Mohamed
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- 2023
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66. Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy)
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Lorenzo Gianguzzi, Riccardo Guarino, Giuseppe Bazan, Romeo Di Pietro, Alicia Teresa Rosario Acosta, Enrico Bajona, Peter Bolliger, Costantino Bonomi, Adriano Camuffo, Carlo Console, Simonetta Fascetti, Paola Fortini, Annarita Frattaroli, Giacomo Mei, Fabio Mondello, Silvia Olivari, Masin Rizzieri, Leonardo Rosati, Simona Sarmati, Leonardo Scuderi, Marco Simonazzi, Giovanni Spampinato, Lucia Viegi, and Adriano Stinca
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Botany ,QK1-989 - Abstract
The results of the annual excursion of the Working Group for Vegetation Science of the Italian Botanical Society, held in the Egadi Islands, Mount San Giuliano and Mount Cofano (W Sicily) on April 23–27 2022, are presented. This paper includes: (1) general information on the visited sites; (2) geology and geomorphology; (3) climatology and bioclimatology with tables of climatic data; (4) description of the following five geobotanical itineraries – accompanied by 29 original vegetation relevés and 11 synthetic relevés, proceeding from different bibliographic references: (a) Mount San Giuliano; (b) Marettimo Island: coastal and sub-coastal stretch of the southern part, between Punta Bassana and Contrada Chiappera; (c) Marettimo Island: Case Romane, Mount Pizzo Falcone and the north-western coastal stretch; (d) Island of Levanzo; (e) Mount Cofano – with catenal pictograms of the vegetation, surveys and description of the plant communities and related syntaxonomic scheme; (5) list of the surveyed plant taxa, collected specimens and herbaria in which they are deposited. A new syntaxon is also described (Catapodio pauciflori-Moraeetum sisyrinchii ass. nova), referring to an ephemeral dry grassland located along the north-western coastal stretch of Marettimo. The new association is framed in the Plantagini-Catapodion balearici, alliance of the Stipo-Bupleuretalia semicompositi order of the class Stipo-Trachynietea distachyae (order Stipo-Bupleuretalia semicompositi, alliance Plantagini-Catapodion balearici). An original synoptic table, regarding 17 different plant communities with high frequency of Moraea sisyrinchium, provides a comparative framework of the new association with allied vegetation units so far described throughout the Mediterranean region. Syntaxonomical and nomenclatural remarks regarding the Mediterranean vegetation occurring in this territory are also given throughout the text. Some floristic updates for the study sites are also reported, including the discovery for the first time in Sicily of Lysimachia loeflingii.
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- 2023
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67. Machine learning to improve interpretability of clinical, radiological and panel-based genomic data of glioma grade 4 patients undergoing surgical resection
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Michele Dal Bo, Maurizio Polano, Tamara Ius, Federica Di Cintio, Alessia Mondello, Ivana Manini, Enrico Pegolo, Daniela Cesselli, Carla Di Loreto, Miran Skrap, and Giuseppe Toffoli
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Glioma ,Machine learning ,Prognosis ,Carmustine wafer ,Tumor mutational burden ,Medicine - Abstract
Abstract Background Glioma grade 4 (GG4) tumors, including astrocytoma IDH-mutant grade 4 and the astrocytoma IDH wt are the most common and aggressive primary tumors of the central nervous system. Surgery followed by Stupp protocol still remains the first-line treatment in GG4 tumors. Although Stupp combination can prolong survival, prognosis of treated adult patients with GG4 still remains unfavorable. The introduction of innovative multi-parametric prognostic models may allow refinement of prognosis of these patients. Here, Machine Learning (ML) was applied to investigate the contribution in predicting overall survival (OS) of different available data (e.g. clinical data, radiological data, or panel-based sequencing data such as presence of somatic mutations and amplification) in a mono-institutional GG4 cohort. Methods By next-generation sequencing, using a panel of 523 genes, we performed analysis of copy number variations and of types and distribution of nonsynonymous mutations in 102 cases including 39 carmustine wafer (CW) treated cases. We also calculated tumor mutational burden (TMB). ML was applied using eXtreme Gradient Boosting for survival (XGBoost-Surv) to integrate clinical and radiological information with genomic data. Results By ML modeling (concordance (c)- index = 0.682 for the best model), the role of predicting OS of radiological parameters including extent of resection, preoperative volume and residual volume was confirmed. An association between CW application and longer OS was also showed. Regarding gene mutations, a role in predicting OS was defined for mutations of BRAF and of other genes involved in the PI3K-AKT-mTOR signaling pathway. Moreover, an association between high TMB and shorter OS was suggested. Consistently, when a cutoff of 1.7 mutations/megabase was applied, cases with higher TMB showed significantly shorter OS than cases with lower TMB. Conclusions The contribution of tumor volumetric data, somatic gene mutations and TBM in predicting OS of GG4 patients was defined by ML modeling.
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- 2023
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68. Flowering phenophases influence the antibacterial and anti-biofilm effects of Thymus vulgaris L. essential oil
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Csongor Bakó, Viktória Lilla Balázs, Erika Kerekes, Béla Kocsis, Dávid U. Nagy, Péter Szabó, Giuseppe Micalizzi, Luigi Mondello, Judit Krisch, Dóra Pethő, and Györgyi Horváth
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Thymus vulgaris ,Thyme essential oil ,Phenophase ,TLC-DB ,Anti-biofilm effect ,SEM ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Essential oils are becoming increasingly popular in medicinal applications because of their antimicrobial effect. Thymus vulgaris L. (Lamiaceae) is a well-known and widely cultivated medicinal plant, which is used as a remedy for cold, cough and gastrointestinal symptoms. Essential oil content of thyme is responsible for its antimicrobial activity, however, it has been reported that the chemical composition of essential oils influences its biological activity. In order to explore flowering phenophases influence on the chemical composition of thyme essential oil and its antibacterial and anti-biofilm activity, plant materials were collected at the beginning of flowering, in full bloom and at the end of flowering periods in 2019. Methods Essential oils from fresh and dried plant materials were distilled and analyzed with gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detection (GC-FID). The antibacterial activity was performed by broth microdilution and thin layer chromatography-direct bioautography (TLC-DB) assays and the anti-biofilm effect by crystal violet assay, respectively. Scanning electron microscopy was applied to illustrate the cellular changes of bacterial cells after essential oil treatment. Results Thymol (52.33–62.46%) was the main component in the thyme essential oils. Thyme oil distilled from fresh plant material and collected at the beginning of flowering period exerted the highest antibacterial and anti-biofilm activity against Haemophilus influenzae, H. parainfluenzae and Pseudomonas aeruginosa. Conclusion The different flowering periods of Thymus vulgaris influence the antibacterial and anti-biofilm activity of its essential oils, therefore, the collection time has to be taken into consideration and not only the full bloom, but the beginning of flowering period may provide biological active thyme essential oil.
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- 2023
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69. Machine learning in onco-pharmacogenomics: a path to precision medicine with many challenges
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Alessia Mondello, Michele Dal Bo, Giuseppe Toffoli, and Maurizio Polano
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pharmacogenomics ,machine learning ,omics ,targeted therapy ,drug toxicity ,drug efficacy ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Over the past two decades, Next-Generation Sequencing (NGS) has revolutionized the approach to cancer research. Applications of NGS include the identification of tumor specific alterations that can influence tumor pathobiology and also impact diagnosis, prognosis and therapeutic options. Pharmacogenomics (PGx) studies the role of inheritance of individual genetic patterns in drug response and has taken advantage of NGS technology as it provides access to high-throughput data that can, however, be difficult to manage. Machine learning (ML) has recently been used in the life sciences to discover hidden patterns from complex NGS data and to solve various PGx problems. In this review, we provide a comprehensive overview of the NGS approaches that can be employed and the different PGx studies implicating the use of NGS data. We also provide an excursus of the ML algorithms that can exert a role as fundamental strategies in the PGx field to improve personalized medicine in cancer.
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- 2024
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70. Moduli of spherical tori with one conical point
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Eremenko, Alexandre, Mondello, Gabriele, and Panov, Dmitri
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Mathematics - Differential Geometry ,Mathematics - Geometric Topology - Abstract
In this paper we determine the topology of the moduli space $\mathcal{MS}_{1,1}(\vartheta)$ of surfaces of genus one with a Riemannian metric of constant curvature $1$ and one conical point of angle $2\pi\vartheta$. In particular, for $\vartheta\in (2m-1,2m+1)$ non-odd, $\mathcal{MS}_{1,1}(\vartheta)$ is connected, has orbifold Euler characteristic $-m^2/12$, and its topology depends on the integer $m>0$ only. For $\vartheta=2m+1$ odd, $\mathcal{MS}_{1,1}(2m+1)$ has $\lceil{m(m+1)/6}\rceil$ connected components. For $\vartheta=2m$ even, $\mathcal{MS}_{1,1}(2m)$ has a natural complex structure and it is biholomorphic to $\mathbb{H}^2/G_m$ for a certain subgroup $G_m$ of $\mathrm{SL}(2,\mathbb{Z})$ of index $m^2$, which is non-normal for $m>1$., Comment: 64 pages, 9 figures
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- 2020
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71. Moduli spaces for Lam\'e functions and Abelian integrals of the second kind
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Eremenko, Alexandre, Gabrielov, Andrei, Mondello, Gabriele, and Panov, Dmitri
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Mathematics - Complex Variables ,Mathematical Physics ,Mathematics - Geometric Topology ,33E10, 30F30, 57M50 - Abstract
The space of Lam\'e functions of order m is isomorphic to the space of pairs (elliptic curve, Abelian differential) where the differential has a single zero of order 2m at the origin and m double poles with vanishing residues. We describe the topology of this space: it is a Riemann surface of finite type; we find the number of components and the genus and Euler characteristic of each component. As an application we find the degrees of Cohn's polynomials confirming a conjecture by Robert Maier. As another application we partially describe the degeneration locus of the space of spherical metrics on tori with one conic singularity where the conic angle is an odd multiple of 2$\pi$., Comment: 82 pages, 18 figures
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- 2020
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72. MicroRNA and long non-coding RNA analysis in IgM-monoclonal gammopathies reveals epigenetic influence on cellular functions and oncogenesis
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Karan Chohan, Jonas Paludo, Surendra Dasari, Patrizia Mondello, Joseph P Novak, Jithma P. Abeykoon, Kerstin Wenzl, Zhi-Zhang Yang, Shahrzad Jalali, Jordan E Krull, Esteban Braggio, Michelle K. Manske, Aneel Paulus, Craig B. Reeder, Sikander Ailawadhi, Asher Chanan-Khan, Prashant Kapoor, Robert A. Kyle, Morie A Gertz, Anne J. Novak, and Stephen M. Ansell
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
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73. Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects
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Firas Kobeissy, Mona Goli, Hamad Yadikar, Zaynab Shakkour, Milin Kurup, Muhammad Ali Haidar, Shahad Alroumi, Stefania Mondello, Kevin K. Wang, and Yehia Mechref
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proteomics ,neuroproteomics ,neurotrauma ,personalized medicine (PM) ,traumatic brain injuries (TBI) ,artificial intelligence (AI) ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has garnered significant attention in the context of neurotrauma research. Neuroproteomics involves the quantitative and qualitative analysis of nervous system components, essential for understanding the dynamic events involved in the vast areas of neuroscience, including, but not limited to, neuropsychiatric disorders, neurodegenerative disorders, mental illness, traumatic brain injury, chronic traumatic encephalopathy, and other neurodegenerative diseases. With advancements in mass spectrometry coupled with bioinformatics and systems biology, neuroproteomics has led to the development of innovative techniques such as microproteomics, single-cell proteomics, and imaging mass spectrometry, which have significantly impacted neuronal biomarker research. By analyzing the complex protein interactions and alterations that occur in the injured brain, neuroproteomics provides valuable insights into the pathophysiological mechanisms underlying neurotrauma. This review explores how such insights can be harnessed to advance personalized medicine (PM) approaches, tailoring treatments based on individual patient profiles. Additionally, we highlight the potential future prospects of neuroproteomics, such as identifying novel biomarkers and developing targeted therapies by employing artificial intelligence (AI) and machine learning (ML). By shedding light on neurotrauma’s current state and future directions, this review aims to stimulate further research and collaboration in this promising and transformative field.
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- 2023
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74. Probing Mechanisms Driving Opioid Use Disorder Comorbidity with Post-Traumatic Stress Disorder and Chronic Pain
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Mondello, Jamie Elizabeth
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Neurosciences ,Psychobiology ,Chronic Pain ,Kappa opioid receptors ,Opioids ,OUD ,PTSD ,Stress - Abstract
Opioid Use Disorder (OUD) is highly comorbid with post-traumatic stress disorder (PTSD) and chronic pain, resulting in exacerbated symptoms and poorer treatment outcomes. Studying each of these disorders in isolation fails to capture the complexity of the interrelationships between OUD and PTSD/chronic pain. OUD, PTSD and chronic pain share common symptomology, risk factors, and impacted neurocircuitry, suggesting that these disorders share common mechanistic pathways that cross-sensitize and influence each other. For instance, OUD, PTSD and chronic pain are all marked by altered learning mechanisms that impact the pathophysiology of these disorders. Additionally, alterations in the dynorphin/kappa opioid receptor (KOR) system caused by stress and chronic pain are an emerging target for OUD comorbidities, due to involvement of this system in negative affect and stress-induced relapse of drug seeking. The goal of this presented dissertation is to shed light on the stress- and pain-induced neuroadaptations that may promote vulnerability for enhanced opioid learning and reward. In Chapter 2, a rodent model of PTSD was utilized to test the impact of unpredictable stress on opioid-induced locomotion and opioid-context learning. We found that while unpredictable stress had no impact on subsequent morphine reward learning, it sensitized the locomotor response to low dose morphine. Interestingly, unpredictable stress also induced preference to contexts previously paired with low dose naltrexone, an opioid receptor antagonist that is typically considered aversive. In Chapter 3, a chronic neuropathic pain model was utilized to test the impact of neuropathic pain on KOR agonist-induced reinstatement of oxycodone place preference. Here, we found that KOR agonism-induced reinstatement in neuropathic pain females, but not neuropathic pain males, supporting previous findings that chronic pain-induced changes in the dynorphin/KOR system are sexually dimorphic. We additionally found a relationship between the magnitude of the reinstatement and mechanical withdrawal thresholds in neuropathic pain females. Specifically, females with greater mechanical allodynia had greater subsequent reinstatement of oxycodone place preference. Overall, this work underscores the need for integrated approaches to address the intricate interplay between OUD, PTSD, and chronic pain comorbidities.
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- 2024
75. Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group
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Olsen, Alexander, Babikian, Talin, Bigler, Erin D, Caeyenberghs, Karen, Conde, Virginia, Dams-O’Connor, Kristen, Dobryakova, Ekaterina, Genova, Helen, Grafman, Jordan, Håberg, Asta K, Heggland, Ingrid, Hellstrøm, Torgeir, Hodges, Cooper B, Irimia, Andrei, Jha, Ruchira M, Johnson, Paula K, Koliatsos, Vassilis E, Levin, Harvey, Li, Lucia M, Lindsey, Hannah M, Livny, Abigail, Løvstad, Marianne, Medaglia, John, Menon, David K, Mondello, Stefania, Monti, Martin M, Newcombe, Virginia FJ, Petroni, Agustin, Ponsford, Jennie, Sharp, David, Spitz, Gershon, Westlye, Lars T, Thompson, Paul M, Dennis, Emily L, Tate, David F, Wilde, Elisabeth A, and Hillary, Frank G
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Biological Psychology ,Psychology ,Traumatic Brain Injury (TBI) ,Neurosciences ,Traumatic Head and Spine Injury ,Biomedical Imaging ,Clinical Research ,Brain Disorders ,Emerging Infectious Diseases ,Physical Injury - Accidents and Adverse Effects ,Injuries and accidents ,Neurological ,Good Health and Well Being ,Adult ,Brain ,Brain Injuries ,Traumatic ,Humans ,Magnetic Resonance Imaging ,Neuroimaging ,Reproducibility of Results ,Brain injury ,Radiology ,Open Science ,Neurodegeneration ,Rehabilitation ,ENIGMA ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Experimental Psychology ,Biomedical and clinical sciences ,Health sciences - Abstract
The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group's short-term, intermediate, and long-term goals.
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- 2021
76. Automated sample preparation and fast GC–MS determination of fatty acids in blood samples and dietary supplements
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Ferracane, Antonio, Aloisi, Ivan, Galletta, Micaela, Zoccali, Mariosimone, Tranchida, Peter Q., Micalizzi, Giuseppe, and Mondello, Luigi
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- 2022
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77. High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI
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Rezoagli, Emanuele, Petrosino, Matteo, Rebora, Paola, Menon, David K., Mondello, Stefania, Cooper, D. James, Maas, Andrew I. R., Wiegers, Eveline J. A., Galimberti, Stefania, and Citerio, Giuseppe
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- 2022
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78. Strict liability, scarce generic input and duopoly competition
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Mondello, Gérard
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- 2022
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79. Hyoid Bone Fracture Pattern Assessment in the Forensic Field: The Importance of Post Mortem Radiological Imaging
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Vincenzo Cianci, Cristina Mondello, Annalisa Cracò, Alessio Cianci, Antonio Bottari, Patrizia Gualniera, Michele Gaeta, Alessio Asmundo, and Daniela Sapienza
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manual strangulation ,charred corpse ,forensic pathology ,PMCT ,post mortem CT ,hyoid bone fracture ,Medicine (General) ,R5-920 - Abstract
Post mortem hyoid bone fracture findings may be attributable to various factors, including both the onset of acute mechanical asphyxia as it happens in manual strangulation and in charred corpses. In forensic practice, the discovery of corpses burned after death to hide their real cause of death is not uncommon: in these cases, the diagnostic challenge is even greater, as the action of flames is capable of both masking previously generated lesions and/or generating new ones, as occurs for hyoid bone fractures. The case concerns a 76-year-old man found charred in his bedroom. Almost complete body charring made it impossible to evaluate any external damage. Post mortem computed tomography (PMCT) was performed, and an evident bilateral fracture of the greater horn of the hyoid bone was detected. Although the absence of typical charring signs had steered the diagnosis towards post mortem exposure to flames, PMCT proved to be very useful in increasing the accuracy in correctly determining the cause of death. In particular, making use of Maximum Intensity Projection (MIP) hyoid bone reconstructions, it was possible to measure the medial dislocation angle of the fracture fragments and then to establish the applied direction of force, which acted in a lateral–medial way. A manual strangulation diagnosis was confirmed. The increasing importance of performing post mortem radiological exams as a corollary for conventional autopsy has been further confirmed.
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- 2024
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80. The Prognostic Role of Candidate Serum Biomarkers in the Post-Acute and Chronic Phases of Disorder of Consciousness: A Preliminary Study
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Rita Formisano, Mariagrazia D’Ippolito, Marco Giustini, Sheila Catani, Stefania Mondello, Iliana Piccolino, Filomena Iannuzzi, Kevin K. Wang, and Ronald L. Hayes
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acquired brain injury ,prolonged disorders of consciousness ,serum biomarkers ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Introduction: Serum biomarkers, such as Neurofilament Light (NF-L), Glial Fibrillary Acidic Protein (GFAP), Ubiquitin C-terminal Hydrolase (UCH-L1), and Total-tau (T-Tau) have been proposed for outcome prediction in the acute phase of severe traumatic brain injury, but they have been less investigated in patients with prolonged DoC (p-DoC). Methods: We enrolled 25 p-DoC patients according to the Coma Recovery Scale-Revised (CRS-R). We identified different time points: injury onset (t0), first blood sampling at admission in Neurorehabilitation (t1), and second blood sampling at discharge (t2). Patients were split into improved (improved level of consciousness from t1 to t2) and not-improved (unchanged or worsened level of consciousness from t1 to t2). Results: All biomarker levels decreased over time, even though each biomarker reveals typical features. Serum GFAP showed a weak correlation between t1 and t2 (p = 0.001), while no correlation was observed for serum NF-L (p = 0.955), UCH-L1 (p = 0.693), and T-Tau (p = 0.535) between t1 and t2. Improved patients showed a significant decrease in the level of NF-L (p = 0.0001), UCH-L1 (p = 0.001), and T-Tau (p = 0.002), but not for serum GFAP (p = 0.283). No significant statistical differences were observed in the not-improved group. Conclusions: A significant correlation was found between the level of consciousness improvement and decreased NF-L, UCH-L1, and T-Tau levels. Future studies on the association of serum biomarkers with neurophysiological and neuroimaging prognostic indicators are recommended.
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- 2024
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81. Arrhythmogenic Right Ventricular Cardiomyopathy Post-Mortem Assessment: A Systematic Review
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Vincenzo Cianci, Elena Forzese, Daniela Sapienza, Alessio Cianci, Antonio Ieni, Antonino Germanà, Maria Cristina Guerrera, Fausto Omero, Desirèe Speranza, Annalisa Cracò, Alessio Asmundo, Patrizia Gualniera, and Cristina Mondello
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arrhythmogenic right ventricular cardiomyopathy ,post-mortem analysis ,post-mortem genetic test ,cardiomyopathy ,family screening for cardiomyopathies ,sudden cardiac death ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder characterized by the progressive fibro-fatty replacement of the right ventricular myocardium, leading to myocardial atrophy. Although the structural changes usually affect the right ventricle, the pathology may also manifest with either isolated left ventricular myocardium or biventricular involvement. As ARVC shows an autosomal dominant pattern of inheritance with variable penetrance, the clinical presentation of the disease is highly heterogeneous, with different degrees of severity and patterns of myocardial involvement even in patients of the same familiar group with the same gene mutation: the pathology spectrum ranges from the absence of symptoms to sudden cardiac death (SCD) sustained by ventricular arrhythmias, which may, in some cases, be the first manifestation of an otherwise silent pathology. An evidence-based systematic review of the literature was conducted to evaluate the state of the art of the diagnostic techniques for the correct post-mortem identification of ARVC. The research was performed using the electronic databases PubMed and Scopus. A methodological approach to reach a correct post-mortem diagnosis of ARVC was described, analyzing the main post-mortem peculiar macroscopic, microscopic and radiological alterations. In addition, the importance of performing post-mortem genetic tests has been underlined, which may lead to the correct identification and characterization of the disease, especially in those ARVC forms where anatomopathological investigation does not show evident morphostructural damage. Furthermore, the usefulness of genetic testing is not exclusively limited to the correct diagnosis of the pathology, but is essential for promoting targeted screening programs to the deceased’s family members. Nowadays, the post-mortem diagnosis of ARVC performed by forensic pathologist remains very challenging: therefore, the identification of a clear methodological approach may lead to both a reduction in under-diagnoses and to the improvement of knowledge on the disease.
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- 2024
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82. Correction to: RE‑MIND2: comparative effectiveness of tafasitamab plus lenalidomide versus polatuzumab vedotin/bendamustine/rituximab (pola‑BR), CAR‑T therapies, and lenalidomide/rituximab (R2) based on real‑world data in patients with relapsed/refractory diffuse large B‑cell lymphoma
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Nowakowski, Grzegorz S., Yoon, Dok Hyun, Mondello, Patrizia, Joffe, Erel, Peters, Anthea, Fleury, Isabelle, Greil, Richard, Ku, Matthew, Marks, Reinhard, Kim, Kibum, Zinzani, Pier Luigi, Trotman, Judith, Sabatelli, Lorenzo, Waltl, Eva E., Winderlich, Mark, Sporchia, Andrea, Kurukulasuriya, Nuwan C., Cordoba, Raul, Hess, Georg, and Salles, Gilles
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- 2023
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83. Recent advances in Forensic Geology and Botany for the reconstruction of event dynamics in outdoor crime scenes: A case study
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Roberta Somma, Maria Cascio, Filippo Cucinotta, Fabio Mondello, and Marina Morabito
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Science (General) ,Q1-390 - Abstract
The present research is devoted to criminal investigation regarding the disappearance of two persons suspected to be kidnapped. The multi-disciplinary investigation based on the application of Forensic Geology and Botany allowed to ascertain the pre-mortem active presence of the victims on the event scene. The results of the geological and botanical characterization accomplished on the traces collected on the victims and their belongings (unknown samples) and soils and plants sampled on the scene of events (known samples), allowed to ascertain with a high degree of compatibility as the source of the unknown samples could derive from environments with characteristics similar to those found in the scene of events, suggesting a same common origin for the analysed unknown and known specimens. Peculiar minerals (calcium phosphate rich clays and dolostones), very abundant vegetal particles (thorns and seeds of Erica arborea), and algae associations were particularly useful in linking the victims to the scene of events. The results of the comparative analyses provided fundamental info-investigative data useful for establishing the pre-mortem active presence of the victims on the scene. Furthermore, the most significant positive matches found allowed reconstructing a very detailed walking carried out by the two victims on the event site in the hours immediately preceding their death. These implications were of paramount importance for the judicial system in the solution of this criminal case. The careful examination of mineral composition, textural features as well as of the peculiar assemblages of inorganic and vegetal materials from unknown and known specimens carried out in the case work revealed to be able to provide very strong geological and botanical evidence for supporting criminal investigations. These robust results were achieved by the experts involved in long time-consuming and careful activities and examinations. Furthermore, the geological and botanical investigation carried out demonstrated as the analyses of the relationships ascertained between the victims and the surrounding environment could also support the coroner’s decision on the manner of death and facilitating the understanding of the event dynamics.
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- 2023
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84. Education and training activities in forensic and biomedical sciences: The laser scanner technology
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Roberta Somma, Gennaro Baldino, Alessio Altadonna, Alessio Asmundo, Vincenzo Fodale, Patrizia Gualniera, Cristina Mondello, Chiara Pennisi, Marcello Raffaele, Fabio Salmeri, Elvira Ventura Spagnolo, and Daniela Sapienza
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Science (General) ,Q1-390 - Abstract
The paper reports the results of training experiences in the field of education in forensic and biomedical sciences carried out during two editions of summer schools. Two simulated serious crimes, involving dummies used as victims, were prepared for practitioners in outdoor places. The scenes simulate a suspect murder case of homicide with staging and a corpse concealment with dismembered human remains found into a clandestine grave, respectively. During the simulations, laser scanning technology was applied to reproduce the outdoor crime scenes in order to verify the capacity of the innovative technique as advantageous tool during educational and forensic training. Judicial inspections conducted during the simulation provided preliminary physical evidence, in the fields of forensic medicine, forensic geology, and engineering, highlighting the importance of the multidisciplinary approach. These experiences, through the use of the laser scanner that allowed for the recreation of virtual environments in which practitioners were able to confront crime scenes, demonstrated how such an approach can be useful in education and training activities.
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- 2023
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85. The application of 3D virtual models in the judicial inspection of indoor and outdoor crime scenes
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Gennaro Baldino, Elvira Ventura Spagnolo, Vincenzo Fodale, Chiara Pennisi, Cristina Mondello, Alessio Altadonna, Marcello Raffaele, Fabio Salmeri, Roberta Somma, Alessio Asmundo, and Daniela Sapienza
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Science (General) ,Q1-390 - Abstract
The multidisciplinary approach has become an almost indispensable requirement in the examination of the scena criminis, especially in complex cases involving different professional profiles within the biomedical and forensic sciences. In recent times, innovative methods have been joined by the possibility of using three-dimensional laser scanners, capable of obtaining virtual reconstructions, very useful in analyzing outdoor or indoor crime scenes. In the present paper, three case studies regarding simulated indoor and outdoor crime scenes were analyzed, applying a virtual reconstruction based on a survey and acquisition of “point clouds” by using a laser scanner Leica BLK360, managed by means of the software Leica Cyclone. Victims were simulated by two hyper-realistic dummies produced by the Lifecast Body Simulation. The first crime scene regarded a suspect homicide case of a man found hanged to a metallic rod indoor, inside a room; the second crime scene regarded a homicide case of a woman, suspected to be victim of sexual assault, found indoor, on the floor of a corridor in a palace; the third scene regarded an outdoor place located in the hills of the Peloritani Mountains, simulating a crime scene where a homicide was committed. The advantages and disadvantages of virtual three-dimensional acquisitions in relation to forensic purposes were finally highlighted. The successful outcome of the scans proved the true-to-life reproducibility of virtual targets, with the possibility of easier interactions, the possibility to measure specific parameters, adequate simulations, and the essential “crystallization” of physical evidence. In the next future, it will be important improving the procedure in order to obtain protocols with high quality standards, able to ensure that the acquired data will be considered valid with evidentiary effect in judicial trials.
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- 2023
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86. Macrobotanic data implementing Forensic Geology investigations
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Marina Morabito, Fabio Mondello, and Roberta Somma
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Science (General) ,Q1-390 - Abstract
The contribution of botany to the analysis of geological traces should not be neglected in forensic investigations. Small plant traces, especially if widespread in quantity, easily adhere to the subjects involved in criminal events. However, the identification of highly fragmentated plant structures often relies to skilled experts. The present paper deals with the morphological descriptions of thorns and similar plant appendices produced by the plants thriving in the area under investigation in a court case regarding the disappearance of two subjects in a rural area of the countryside. Comparative observations between unknown and known samples, related to victims and crime scene respectively, made it possible to identify traces found on the victims as plants thriving in the area under investigations. Basing on the punctual distribution of individual plants in the investigated territory, the results of the comparative analyses allowed to reconstruct the victims’ path in the hours immediately preceding their death. Consequently, these data provided valuable information for implementing the geological investigation carried out for the judicial authority.
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- 2023
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87. P1215: CHARACTERIZATION AND CLINICAL SIGNIFICANCE OF T FOLLICULAR HELPER SUBSETS IN FOLLICULAR LYMPHOMA
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Zhi-Zhang Yang, Xinyi Tang, Hyo Jin Kim, Vaishali Bhardwaj, Prithviraj Mukherjee, Patrizia Mondello, Jose Villasboas, Anne Novak, and Stephen Ansell
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
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88. The potential role of Aureobasidium pullulans in the development of foliar symptoms of Esca disease in grapevine
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Zoltán Karácsony, Vincenzo Mondello, Florence Fontaine, and Kálmán Zoltán Váczy
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grapevine trunk disease ,pathogenesis ,Phaeomoniella chlamydospora ,microbial interaction ,Agriculture ,Botany ,QK1-989 - Abstract
Esca belongs to the group of grapevine trunk diseases - fungal diseases present worldwide in all wine-growing regions. Some aspects of the disease, like the development of external symptoms, have still not been completely discovered and are believed to be affected by several factors, including interactions within the vine microbiome. The examination of the occurrence of the yeast-like fungus Aureobasidium pullulans in the healthy wood of Esca-diseased grapevines via both isolation and qPCR measurements showed a positive correlation between its abundance and the severity of foliar symptoms, suggesting the contribution of this fungus to Esca pathogenesis via an indirect action. In vitro confrontation tests revealed antagonistic interaction between A. pullulans and the Esca pathogen Phaeomoniella chlamydospora. Mutual growth inhibition and the induction of asexual sporogenesis were observed for both fungi without cytotoxic effects. In planta confrontation tests revealed that A. pullulans in combination with P. chlamydospora can lead to severe foliar damage in a strain-dependent manner. This phenomenon could be explained by the altered metabolism of the Esca pathogen in the presence of A. pullulans, or by the cumulative/synergistic effects of the secreted polysaccharides and/or proteins of the two fungi. The present study shows the importance of microbial interactions in the development of plant diseases, highlighting that even a non-pathogenic microorganism can act as a disease-enhancer.
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- 2023
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89. Minimizing immersions of a hyperbolic surface in a hyperbolic $3$-manifold
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Bonsante, Francesco, Mondello, Gabriele, and Schlenker, Jean-Marc
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Mathematics - Differential Geometry ,Mathematics - Geometric Topology - Abstract
Let $(S,h)$ be a closed hyperbolic surface and $M$ be a quasi-Fuchsian 3-manifold. We consider incompressible maps from $S$ to $M$ that are critical points of an energy functional $F$ which is homogeneous of degree $1$. These "minimizing" maps are solutions of a non-linear elliptic equation, and reminiscent of harmonic maps -- but when the target is Fuchsian, minimizing maps are minimal Lagrangian diffeomorphisms to the totally geodesic surface in $M$. We prove the uniqueness of smooth minimizing maps from $(S,h)$ to $M$ in a given homotopy class. When $(S,h)$ is fixed, smooth minimizing maps from $(S,h)$ are described by a simple holomorphic data on $S$: a complex self-adjoint Codazzi tensor of determinant $1$. The space of admissible data is smooth and naturally equipped with a complex structure, for which the monodromy map taking a data to the holonomy representation of the image is holomorphic. Minimizing maps are in this way reminiscent of shear-bend coordinates, with the complexification of $F$ analoguous to the complex length., Comment: 30 pages, no figure
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- 2019
90. Non-existence of Yamabe minimizers on singular spheres
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Akutagawa, Kazuo and Mondello, Ilaria
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Mathematics - Differential Geometry - Abstract
We prove that a minimizer of the Yamabe functional does not exist for a sphere $\mathbb{S}^n$ of dimension $n \geq 3$, endowed with a standard edge-cone spherical metric of cone angle greater than or equal to $4\pi$, along a great circle of codimension two. When the cone angle along the singularity is smaller than $2\pi$, the corresponding metric is known to be a Yamabe metric, and we show that all Yamabe metrics in its conformal class are obtained from it by constant multiples and conformal diffeomorphisms preserving the singular set.
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- 2019
91. Sphere theorems for RCD and stratified spaces
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Honda, Shouhei and Mondello, Ilaria
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Mathematics - Differential Geometry - Abstract
We prove topological sphere theorems for RCD(n-1, n) spaces which generalize Colding's results and Petersen's result to the RCD setting. We also get an improved sphere theorem in the case of Einstein stratified spaces.
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- 2019
92. The Compact Linear Collider (CLIC) - 2018 Summary Report
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CLIC, The, collaborations, CLICdp, Charles, T. K., Giansiracusa, P. J., Lucas, T. G., Rassool, R. P., Volpi, M., Balazs, C., Afanaciev, K., Makarenko, V., Patapenka, A., Zhuk, I., Collette, C., Boland, M. J., Hoffman, A. C. Abusleme, Diaz, M. A., Garay, F., Chi, Y., He, X., Pei, G., Pei, S., Shu, G., Wang, X., Zhang, J., Zhao, F., Zhou, Z., Chen, H., Gao, Y., Huang, W., Kuang, Y. P., Li, B., Li, Y., Meng, X., Shao, J., Shi, J., Tang, C., Wang, P., Wu, X., Zha, H., Ma, L., Han, Y., Fang, W., Gu, Q., Huang, D., Huang, X., Tan, J., Wang, Z., Zhao, Z., Uggerhøj, U. I., Wistisen, T. N., Aabloo, A., Aare, R., Kuppart, K., Vigonski, S., Zadin, V., Aicheler, M., Baibuz, E., Brücken, E., Djurabekova, F., Eerola, P., Garcia, F., Haeggström, E., Huitu, K., Jansson, V., Kassamakov, I., Kimari, J., Kyritsakis, A., Lehti, S., Meriläinen, A., Montonen, R., Nordlund, K., Österberg, K., Saressalo, A., Väinölä, J., Veske, M., Farabolini, W., Mollard, A., Peauger, F., Plouin, J., Bambade, P., Chaikovska, I., Chehab, R., Delerue, N., Davier, M., Faus-Golfe, A., Irles, A., Kaabi, W., LeDiberder, F., Pöschl, R., Zerwas, D., Aimard, B., Balik, G., Blaising, J. -J., Brunetti, L., Chefdeville, M., Dominjon, A., Drancourt, C., Geoffroy, N., Jacquemier, J., Jeremie, A., Karyotakis, Y., Nappa, J. M., Serluca, M., Vilalte, S., Vouters, G., Bernhard, A., Bründermann, E., Casalbuoni, S., Hillenbrand, S., Gethmann, J., Grau, A., Huttel, E., Müller, A. -S., Peiffer, P., Perić, I., de Jauregui, D. Saez, Emberger, L., Graf, C., Simon, F., Szalay, M., van der Kolk, N., Brass, S., Kilian, W., Alexopoulos, T., Apostolopoulos, T., Gazis, E. N., Gazis, N., Kostopoulos, V., Kourkoulis, S., Heilig, B., Lichtenberger, J., Shrivastava, P., Dayyani, M. K., Ghasem, H., Hajari, S. S., Shaker, H., Ashkenazy, Y., Popov, I., Engelberg, E., Yashar, A., Abramowicz, H., Benhammou, Y., Borysov, O., Borysova, M., Levy, A., Levy, I., Alesini, D., Bellaveglia, M., Buonomo, B., Cardelli, A., Diomede, M., Ferrario, M., Gallo, A., Ghigo, A., Giribono, A., Piersanti, L., Stella, A., Vaccarezza, C., de Blas, J., Franceschini, R., D'Auria, G., Di Mitri, S., Abe, T., Aryshev, A., Fukuda, M., Furukawa, K., Hayano, H., Higashi, Y., Higo, T., Kubo, K., Kuroda, S., Matsumoto, S., Michizono, S., Naito, T., Okugi, T., Shidara, T., Tauchi, T., Terunuma, N., Urakawa, J., Yamamoto, A., Raboanary, R., Luiten, O. J., Stragier, X. F. D., Hart, R., van der Graaf, H., Eigen, G., Adli, E., Lindstrøm, C. A., Lillestøl, R., Malina, L., Pfingstner, J., Sjobak, K. N., Ahmad, A., Hoorani, H., Khan, W. A., Bugiel, S., Bugiel, R., Firlej, M., Fiutowski, T. A., Idzik, M., Moroń, J., Świentek, K. P., de Renstrom, P. Brückman, Krupa, B., Kucharczyk, M., Lesiak, T., Pawlik, B., Sopicki, P., Turbiarz, B., Wojtoń, T., Zawiejski, L. K., Kalinowski, J., Nowak, K., Żarnecki, A. F., Firu, E., Ghenescu, V., Neagu, A. T., Preda, T., Zgura, I. S., Aloev, A., Azaryan, N., Boyko, I., Budagov, J., Chizhov, M., Filippova, M., Glagolev, V., Gongadze, A., Grigoryan, S., Gudkov, D., Karjavine, V., Lyablin, M., Nefedov, Yu., Olyunin, A., Rymbekova, A., Samochkine, A., Sapronov, A., Shelkov, G., Shirkov, G., Soldatov, V., Solodko, E., Trubnikov, G., Tyapkin, I., Uzhinsky, V., Vorozhtov, A., Zhemchugov, A., Levichev, E., Mezentsev, N., Piminov, P., Shatilov, D., Vobly, P., Zolotarev, K., Jelisavčić, I. Božović, Kačarević, G., Dumbelović, G. Milutinović, Pandurović, M., Radulović, M., Stevanović, J., Vukasinović, N., Lee, D. -H., Ayala, N., Benedetti, G., Guenzel, T., Iriso, U., Marti, Z., Perez, F., Pont, M., Trenado, J., Ruiz-Jimeno, A., Vila, I., Calero, J., Dominguez, M., Garcia-Tabares, L., Gavela, D., Lopez, D., Toral, F., Gutierrez, C. Blanch, Boronat, M., Esperante, D., Fullana, E., Fuster, J., García, I., Gimeno, B., Lopez, P. Gomis, González, D., Perelló, M., Ros, E., Villarejo, M. A., Vnuchenko, A., Vos, M., Borgmann, Ch., Brenner, R., Ekelöf, T., Jacewicz, M., Olvegård, M., Ruber, R., Ziemann, V., Aguglia, D., Gonzalvo, J. Alabau, Leon, M. Alcaide, Tehrani, N. Alipour, Anastasopoulos, M., Andersson, A., Andrianala, F., Antoniou, F., Apyan, A., Arominski, D., Artoos, K., Assly, S., Atieh, S., Baccigalupi, C., Sune, R. Ballabriga, Caballero, D. Banon, Barnes, M. J., Garcia, J. Barranco, Bartalesi, A., Bauche, J., Bayar, C., Belver-Aguilar, C., Morell, A. Benot, Bernardini, M., Bett, D. 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Garcia, Garion, C., Gasior, M., Gatignon, L., Gayde, J-C., Gerbershagen, A., Gerwig, H., Giambelli, G., Gilardi, A., Goldblatt, A. N., Anton, S. Gonzalez, Grefe, C., Grudiev, A., Guerin, H., Guillot-Vignot, F. G., Gutt-Mostowy, M. L., Lutz, M. Hein, Hessler, C., Holma, J. K., Holzer, E. B., Hourican, M., Hynds, D., Ikarios, E., Levinsen, Y. Inntjore, Janssens, S., Jeff, A., Jensen, E., Jonker, M., Kamugasa, S. W., Kastriotou, M., Kemppinen, J. M. K., Khan, V., Kieffer, R. B., Klempt, W., Kokkinis, N., Kossyvakis, I., Kostka, Z., Korsback, A., Platia, E. Koukovini, Kovermann, J. W., Kozsar, C-I., Kremastiotis, I., Kröger, J., Kulis, S., Latina, A., Leaux, F., Lebrun, P., Lefevre, T., Leogrande, E., Linssen, L., Liu, X., Cudie, X. Llopart, Magnoni, S., Maidana, C., Maier, A. A., Durand, H. Mainaud, Mallows, S., Manosperti, E., Marelli, C., Lacoma, E. Marin, Marsh, S., Martin, R., Martini, I., Martyanov, M., Mazzoni, S., Mcmonagle, G., Mether, L. M., Meynier, C., Modena, M., Moilanen, A., Mondello, R., Cabral, P. B. Moniz, Irazabal, N. Mouriz, Munker, M., Muranaka, T., Nadenau, J., Navarro, J. G., Quirante, J. L. Navarro, Del Busto, E. Nebo, Nikiforou, N., Ninin, P., Nonis, M., Nisbet, D., Nuiry, F. X., Nürnberg, A., Ögren, J., Osborne, J., Ouniche, A. C., Pan, R., Papadopoulou, S., Papaphilippou, Y., Paraskaki, G., Pastushenko, A., Passarelli, A., Patecki, M., Pazdera, L., Pellegrini, D., Pepitone, K., Codina, E. Perez, Fontenla, A. Perez, Persson, T. H. B., Petrič, M., Pitman, S., Pitters, F., Pittet, S., Plassard, F., Popescu, D., Quast, T., Rajamak, R., Redford, S., Remandet, L., Renier, Y., Rey, S. F., Orozco, O. Rey, Riddone, G., Castro, E. Rodriguez, Roloff, P., Rossi, C., Rossi, F., Rude, V., Ruehl, I., Rumolo, G., Sailer, A., Sandomierski, J., Santin, E., Sanz, C., Bedolla, J. Sauza, Schnoor, U., Schmickler, H., Schulte, D., Senes, E., Serpico, C., Severino, G., Shipman, N., Sicking, E., Simoniello, R., Skowronski, P. 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Physics - Accelerator Physics - Abstract
The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear $e^+e^-$ collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years., Comment: 112 pages, 59 figures; published as CERN Yellow Report Monograph Vol. 2/2018; corresponding editors: Philip N. Burrows, Nuria Catalan Lasheras, Lucie Linssen, Marko Petri\v{c}, Aidan Robson, Daniel Schulte, Eva Sicking, Steinar Stapnes
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- 2018
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93. Insights into the tumor microenvironment of B cell lymphoma
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Wern Lynn Ng, Stephen M. Ansell, and Patrizia Mondello
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Tumor microenvironment ,B-cell lymphoma ,T cells ,T follicular helper cells ,T regulatory cells ,Tumor-associated macrophages ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract The standard therapies in lymphoma have predominantly focused on targeting tumor cells with less of a focus on the tumor microenvironment (TME), which plays a critical role in favoring tumor growth and survival. Such an approach may result in increasingly refractory disease with progressively reduced responses to subsequent treatments. To overcome this hurdle, targeting the TME has emerged as a new therapeutic strategy. The TME consists of T and B lymphocytes, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and other components. Understanding the TME can lead to a comprehensive approach to managing lymphoma, resulting in therapeutic strategies that target not only cancer cells, but also the supportive environment and thereby ultimately improve survival of lymphoma patients. Here, we review the normal function of different components of the TME, the impact of their aberrant behavior in B cell lymphoma and the current TME-direct therapeutic avenues.
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- 2022
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94. BORN study: a multicenter randomized trial investigating cord blood red blood cell transfusions to reduce the severity of retinopathy of prematurity in extremely low gestational age neonates
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Luciana Teofili, Patrizia Papacci, Nicoletta Orlando, Maria Bianchi, Tina Pasciuto, Iolanda Mozzetta, Fernando Palluzzi, Luciano Giacò, Carmen Giannantonio, Giulia Remaschi, Michela Santosuosso, Enrico Beccastrini, Marco Fabbri, Caterina Giovanna Valentini, Tiziana Bonfini, Eleonora Cloclite, Patrizia Accorsi, Antonella Dragonetti, Francesco Cresi, Giulia Ansaldi, Genny Raffaeli, Stefania Villa, Giulia Pucci, Isabella Mondello, Michele Santodirocco, Stefano Ghirardello, and Giovanni Vento
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Extremely low gestational age neonates ,Retinopathy of prematurity ,Transfusions ,Fetal hemoglobin ,Umbilical blood ,Randomized controlled trial ,Medicine (General) ,R5-920 - Abstract
Abstract Background Extremely low gestational age neonates (ELGANs, i.e., neonates born before 28 weeks of gestation) are at high risk of developing retinopathy of prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement of fetal hemoglobin (HbF) by adult hemoglobin (HbA). Furthermore, a close association exists between low levels of HbF and severe ROP, suggesting that a perturbation of the HbF-mediated oxygen release may derange retinal angiogenesis and promote ROP. Methods/design BORN (umBilical blOod to tRansfuse preterm Neonates) is a multicenter double-blinded randomized controlled trial in ELGANs, to assess the effect of allogeneic cord blood RBC transfusions (CB-RBCs) on severe ROP development. Recruitment, consent, and randomization take place at 10 neonatology intensive care units (NICUs) of 8 Italian tertiary hospitals. ELGANs with gestational age at birth comprised between 24+0 and 27+6 weeks are randomly allocated into two groups: (1) standard RBC transfusions (adult-RBCs) (control arm) and (2) CB-RBCs (intervention arm). In case of transfusion need, enrolled patients receive transfusions according to the allocation arm, unless an ABO/RhD CB-RBC is unavailable. Nine Italian public CB banks cooperate to make available a suitable amount of CB-RBC units for all participating NICUs. The primary outcome is the incidence of severe ROP (stage 3 or higher) at discharge or 40 weeks of postmenstrual age, which occurs first. Discussion BORN is a groundbreaking trial, pioneering a new transfusion approach dedicated to ELGANs at high risk for severe ROP. In previous non-randomized trials, this transfusion approach was proven feasible and able to prevent the HbF decrease in patients requiring multiple transfusions. Should the BORN trial confirm the efficacy of CB-RBCs in reducing ROP severity, this transfusion strategy would become the preferential blood product to be used in severely preterm neonates. Trial registration ClinicalTrials.gov NCT05100212. Registered on October 29, 2021
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- 2022
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95. Kostensatz für geplante Investitionen berechnen
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Mondello, Enzo
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- 2022
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96. Sustainability in (bio-)analytical chemistry
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Baeumner, Antje J., Gauglitz, Günter, Mondello, Luigi, Bondi, María Cruz Moreno, Szunerits, Sabine, Wang, Qiuquan, Wise, Stephen A., and Woolley, Adam T.
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- 2022
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97. Analytical evaluation of carotenoids, apocarotenoids, capsaicinoids, and phenolics to assess the effect of a protective treatment on chili peppers dried at different temperatures
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Grimaldi, Maria, Cavazza, Antonella, Pitirollo, Olimpia, Zoccali, Mariosimone, Mondello, Luigi, and Giuffrida, Daniele
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- 2022
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98. Flow-modulated comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry: use of hydrogen as a more sustainable alternative to helium
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Galletta, Micaela, Zoccali, Mariosimone, Jones, Nick, Mondello, Luigi, and Tranchida, Peter Q.
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- 2022
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99. Non-psychoactive cannabinoids identification by linear retention index approach applied to a hand-portable capillary liquid chromatography platform
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La Tella, Roberta, Rigano, Francesca, Guarnaccia, Paolo, Dugo, Paola, and Mondello, Luigi
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- 2022
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100. A fatal case of neonatal onset multiple acyl-CoA dehydrogenase deficiency caused by novel mutation of ETFDH gene: case report
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Loredana De Pasquale, Petronilla Meo, Francesco Fulia, Antonio Anania, Valerio Meli, Antonina Mondello, Maria Tindara Raimondo, Viviana Tulino, Maria Sole Coletta, and Caterina Cacace
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ETF ,ETFDH ,Glutaric aciduria type II ,Multiple acyl-CoA dehydrogenase deficiency ,Case report ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II is an extremely rare autosomal recessive inborn error of fatty acid beta oxidation and branched-chain amino acids, secondary to mutations in the genes encoding the electron transfer flavoproteins A and B (ETFs; ETFA or ETFB) or ETF dehydrogenase (ETFDH). The clinical manifestation of MADD are heterogeneous, from severe neonatal forms to mild late-onset forms. Case presentation We report the case of a preterm newborn who died a few days after birth for a severe picture of untreatable metabolic acidosis. The diagnosis of neonatal onset MADD was suggested on the basis of clinical features displaying congenital abnormalities and confirmed by the results of expanded newborn screening, which arrived the day the newborn died. Molecular genetic test revealed a homozygous indel variant c.606 + 1 _606 + 2insT in the ETFDH gene, localized in a canonical splite site. This variant, segregated from the two heterozygous parents, is not present in the general population frequency database and has never been reported in the literature. Discussion and conclusion Recently introduced Expanded Newborn Screening is very important for a timely diagnosis of Inherited Metabolic Disorders like MADD. In some cases which are the most severe, diagnosis may arrive after symptoms are already present or may be the neonate already died. This stress the importance of collecting all possible samples to give parents a proper diagnosis and a genetic counselling for future pregnacies.
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- 2022
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