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Zakopane Conference on Nuclear Physics - Extremes of the Nuclear Landscape -- AUG 26-SEP 02, 2018 -- Zakopane, POLAND, WOS: 000463866500051, An experiment aiming at measuring lifetimes of the second 2(+) excited states in neutron-rich C and O isotopes was recently performed at the GANIL laboratory, in France. In these nuclei, recent ab initio calculations provide a detailed description of the nuclear excited states, predicting a strong sensitivity of the electromagnetic transition probabilities to the details of the nucleon-nucleon interactions, especially in connection with the role played by the three-body (NNN) forces. Thus, the measurement of 2(+) states lifetimes in this region will be a stringent test of the importance of including the NNN forces in describing the electromagnetic properties of selected nuclear states. This contribution reports on the status of the experimental analysis for the case of lifetimes in O-20., European Union's Horizon 2020 through ENSAR2 grant [654002]; National Science Centre, Poland (NCN) [2013/08/M/ST2/00257, 2014/14/M/ST2/00738, 2016/22/M/ST2/00269]; COPININ2P3 collaboration, We acknowledge the important technical contributions of J. Goupil and the GANIL accelerator staff. The authors acknowledge support from the European Union's Horizon 2020 through ENSAR2 grant agreement No. 654002, the National Science Centre, Poland (NCN) Contract No. 2013/08/M/ST2/00257, 2014/14/M/ST2/00738 and 2016/22/M/ST2/00269 and COPININ2P3 collaboration.

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Supplemental Material, Bierstetel_LSM_Supplemental_Materials for Associations between language style matching and relationship commitment and satisfaction: An integrative data analysis by Sabrina J. Bierstetel, Allison K. Farrell, Julia L. Briskin, Michael W. Harvey, Shelly L. Gable, Thao Ha, William Ickes, Wei-Fang Lin, Minda M. Orina, Darby Saxbe, Jeffry A. Simpson, Vivian P. Ta and Richard B. Slatcher in Journal of Social and Personal Relationships

This chapter foregrounds the Lab-On-Line project, a technological innovation developed to enhance visual processing skills, improve memory and vocabulary, and increase reading fluency with the explicit aim of improving comprehension. Thirty (30) 3rd year students at one of the University of Namibia campuses participated in the pilot study. A pre-test was conducted for placement purpose. Subsequently, the selected sample commenced with the Lab-On-Line program that consists of 20 lessons that were carried out twice a week over a period of five months. Thereafter a Standardized Reading Evaluation was performed to determine their language proficiency, reading speed per minute and comprehension ability. Results show that the majority of participating students had improved their perceptual development and reading speed (VPF), cognitive development and comprehension skills (CDF), and relative reading efficiency (AIUF).

PurposeShort-term improvements in retinal anatomy are known to occur in preclinical models of photoreceptor transplantation. However, correlative changes over the long term are poorly understood. We aimed to develop a quantifiable imaging biomarker grading scheme, using non-invasive multimodal confocal scanning laser ophthalmoscopy (cSLO) imaging, to enable serial evaluation of photoreceptor transplantation over the long term.MethodsYellow-green fluorescent microspheres were transplanted into the vitreous cavity and/or subretinal space of C57/BL6J mice. Photoreceptor cell suspensions or sheets from rhodopsin-green fluorescent protein mice were transplanted subretinally, into either NOD.CB17-Prkdcscid/J or C3H/HeJ-Pde6brd1 mice. Multimodal cSLO imaging was performed serially for up to three months after transplantation. Imaging biomarkers were scored, and a grade was defined for each eye by integrating the scores. Image grades were correlated with immunohistochemistry (IHC) data.ResultsMultimodal imaging enabled the extraction of quantitative imaging biomarkers including graft size, GFP intensity, graft length, on-target graft placement, intra-graft lamination, hemorrhage, retinal atrophy, and peri-retinal proliferation. Migration of transplanted material was observed. Changes in biomarker scores and grades were detected in 13/16 and 7/16 eyes, respectively. A high correlation was found between image grades and IHC parameters.ConclusionsSerial evaluation of multiple imaging biomarkers, when integrated into a per-eye grading scheme, enabled comprehensive tracking of longitudinal changes in photoreceptor cell grafts over time. The application of systematic multimodal in vivo imaging could be useful in increasing the efficiency of preclinical retinal cell transplantation studies in rodents and other animal models.

Purpose Short-term improvements in retinal anatomy are known to occur in preclinical models of photoreceptor transplantation. However, correlative changes over the long term are poorly understood. We aimed to develop a quantifiable imaging biomarker grading scheme, using noninvasive multimodal confocal scanning laser ophthalmoscopy (cSLO) imaging, to enable serial evaluation of photoreceptor transplantation over the long term. Methods Photoreceptor cell suspensions or sheets from rhodopsin-green fluorescent protein mice were transplanted subretinally, into either NOD.CB17-Prkdcscid/J or C3H/HeJ-Pde6brd1 mice. Multimodal cSLO imaging was performed serially for up to three months after transplantation. Imaging biomarkers were scored, and a grade was defined for each eye by integrating the scores. Image grades were correlated with immunohistochemistry (IHC) data. Results Multimodal imaging enabled the extraction of quantitative imaging biomarkers including graft size, GFP intensity, graft length, on-target graft placement, intra-graft lamination, hemorrhage, retinal atrophy, and periretinal proliferation. Migration of transplanted material was observed. Changes in biomarker scores and grades were detected in 14/16 and 7/16 eyes, respectively. A high correlation was found between image grades and IHC parameters. Conclusions Serial evaluation of multiple imaging biomarkers, when integrated into a per-eye grading scheme, enabled comprehensive tracking of longitudinal changes in photoreceptor cell grafts over time. The application of systematic multimodal in vivo imaging could be useful in increasing the efficiency of preclinical retinal cell transplantation studies in rodents and other animal models. Translational relevance By allowing longitudinal evaluation of the same animal over time, and providing quantifiable biomarkers, non-invasive multimodal imaging improves the efficiency of retinal transplantation studies in animal models. Such assays will facilitate the development of cell therapy for retinal diseases.

Background: The nuclear shape is a macroscopic feature of an atomic nucleus that is sensitive to the underlying nuclear structure in terms of collectivity and the interaction between nucleons. Therefore, the evolution of nuclear shapes has attracted many theoretical and experimental nuclear structure studies. The structure of the A≈ 70 , N≈ Z nuclei, lying far from the stability line, is interesting because a particularly strong proton-neutron correlation may occur here due to the occupation of the same orbits by nucleons of both types. In this region, different particle configurations drive a nucleus towards various deformed shapes: prolate, oblate, octupole, or nonaxial. These nuclear shapes change rapidly with nucleon number and also with angular momentum. This is reflected by a presence of different structures (bands) of excited states which exhibit a broad range of lifetimes. Purpose: The aim of this paper is to determine lifetimes of some high-spin excited states in 69 As and 66 Ge nuclei to examine the shape evolution in these neutron-deficient nuclei. Methods: Lifetimes of high-spin states in 69 As and 66 Ge have been measured by using the Doppler-shift attenuation technique with the GASP and recoil filter detector setup at the Laboratori Nazionali di Legnaro. The nuclei of interest were produced in the 32 S ( 95 MeV ) + 0.8 mg / cm 2 40 Ca fusion-evaporation reaction. The strongest reaction channels 3p and α 2 p led to the 69 As and 66 Ge final nuclei, respectively. Using γ − γ -recoil coincidences we were able to determine very short lifetimes (in the femtosecond range) in the residual nuclei of interest. Results: In 69 As , the extracted lifetimes are τ = 72 ( − 32 , +45 ) fs for the 33 / 2 + state at 7897 keV and τ < 85 fs for the 37 / 2 + state at 9820 keV. For the 66 Ge case, the lifetime of the 11 − state at 7130 keV is τ = 122 ( ± 41 ) fs. Lifetimes in 69 As and 66 Ge reported in this paper have been measured for the first time in the present experiment. Conclusions: The results are discussed in the terms of deformation and shape evolution in 69 As and 66 Ge . The quadrupole moments deduced from the measured lifetimes were compared with the cranked Woods-Saxon-Strutinsky calculations by means of the total Routhian surface method. It turns out that Band 3 in 69 As shows an oblate-prolate shape transition, and above spin 33 / 2 + it corresponds to a prolate collective structure with β 2 ≈ 0.27 and γ ≈ 20 ∘ . In turn, in 66 Ge the negative-parity band built on the 7− state at 4205 keV corresponds to a triaxial shape with β 2 = 0.33 and γ = 31 ∘ . Analysis of the transitional quadrupole moments derived from the experimental and theoretical ones points to a significant change of deformation in the 69 As and 66 Ge nuclei with increasing rotational frequency.

Background: The nuclear shape is a macroscopic feature of an atomic nucleus that is sensitive to the underlying nuclear structure in terms of collectivity and the interaction between nucleons. Therefore, the evolution of nuclear shapes has attracted many theoretical and experimental nuclear structure studies. The structure of the A≈70, N≈Z nuclei, lying far from the stability line, is interesting because a particularly strong proton-neutron correlation may occur here due to the occupation of the same orbits by nucleons of both types. In this region, different particle configurations drive a nucleus towards various deformed shapes: prolate, oblate, octupole, or nonaxial. These nuclear shapes change rapidly with nucleon number and also with angular momentum. This is reflected by a presence of different structures (bands) of excited states which exhibit a broad range of lifetimes. Purpose: The aim of this paper is to determine lifetimes of some high-spin excited states in As69 and Ge66 nuclei to examine the shape evolution in these neutron-deficient nuclei. Methods: Lifetimes of high-spin states in As69 and Ge66 have been measured by using the Doppler-shift attenuation technique with the GASP and recoil filter detector setup at the Laboratori Nazionali di Legnaro. The nuclei of interest were produced in the S32(95MeV)+0.8mg/cm2 Ca40 fusion-evaporation reaction. The strongest reaction channels 3p and α2p led to the As69 and Ge66 final nuclei, respectively. Using γ-γ-recoil coincidences we were able to determine very short lifetimes (in the femtosecond range) in the residual nuclei of interest. Results: In As69, the extracted lifetimes are τ=72 (-32, +45) fs for the 33/2+ state at 7897 keV and τ

International audience; Background: The nuclear shape is a macroscopic feature of an atomic nucleus that is sensitive to the underlying nuclear structure in terms of collectivity and the interaction between nucleons. Therefore, the evolution of nuclear shapes has attracted many theoretical and experimental nuclear structure studies. The structure of the A≈70, N≈Z nuclei, lying far from the stability line, is interesting because a particularly strong proton-neutron correlation may occur here due to the occupation of the same orbits by nucleons of both types. In this region, different particle configurations drive a nucleus towards various deformed shapes: prolate, oblate, octupole, or nonaxial. These nuclear shapes change rapidly with nucleon number and also with angular momentum. This is reflected by a presence of different structures (bands) of excited states which exhibit a broad range of lifetimes. Purpose: The aim of this paper is to determine lifetimes of some high-spin excited states in As69 and Ge66 nuclei to examine the shape evolution in these neutron-deficient nuclei. Methods: Lifetimes of high-spin states in As69 and Ge66 have been measured by using the Doppler-shift attenuation technique with the GASP and recoil filter detector setup at the Laboratori Nazionali di Legnaro. The nuclei of interest were produced in the S32(95MeV)+0.8mg/cm2 Ca40 fusion-evaporation reaction. The strongest reaction channels 3p and α2p led to the As69 and Ge66 final nuclei, respectively. Using γ-γ-recoil coincidences we were able to determine very short lifetimes (in the femtosecond range) in the residual nuclei of interest. Results: In As69, the extracted lifetimes are τ=72 (−32, +45) fs for the 33/2+ state at 7897 keV and τ

Aydın, Sezgin ( Aksaray, Yazar ), Background: The nuclear shape is a macroscopic feature of an atomic nucleus that is sensitive to the underlying nuclear structure in terms of collectivity and the interaction between nucleons. Therefore, the evolution of nuclear shapes has attracted many theoretical and experimental nuclear structure studies. The structure of the A≈70, N≈Z nuclei, lying far from the stability line, is interesting because a particularly strong proton-neutron correlation may occur here due to the occupation of the same orbits by nucleons of both types. In this region, different particle configurations drive a nucleus towards various deformed shapes: prolate, oblate, octupole, or nonaxial. These nuclear shapes change rapidly with nucleon number and also with angular momentum. This is reflected by a presence of different structures (bands) of excited states which exhibit a broad range of lifetimes. Purpose: The aim of this paper is to determine lifetimes of some high-spin excited states in As69 and Ge66 nuclei to examine the shape evolution in these neutron-deficient nuclei. Methods: Lifetimes of high-spin states in As69 and Ge66 have been measured by using the Doppler-shift attenuation technique with the GASP and recoil filter detector setup at the Laboratori Nazionali di Legnaro. The nuclei of interest were produced in the S32(95MeV)+0.8mg/cm2 Ca40 fusion-evaporation reaction. The strongest reaction channels 3p and α2p led to the As69 and Ge66 final nuclei, respectively. Using γ-γ-recoil coincidences we were able to determine very short lifetimes (in the femtosecond range) in the residual nuclei of interest. Results: In As69, the extracted lifetimes are τ=72 (-32, +45) fs for the 33/2+ state at 7897 keV and τ

International audience; In the region around 132Sn, the structure of even-even nuclei demonstrates diverse phenomenon including the transition between some typical quadrupole collective states. The doubly magic isotopic chain of Sn-isotopes seems to be the most interesting mass-region to be studied. Several theoretical and experimental studies have been focused in this mass region, recently [1]. The low-lying spectroscopy of these nuclei is one of the most powerful sources of information about nuclear shapes and shape transitions. Experimental/adopted B(E2↑) values for this mass-region are depicted in Fig. 1.

The advent of stem cell-derived retinal organoids has brought forth unprecedented opportunities for developmental and physiological studies, while presenting new therapeutic promise for retinal degenerative diseases. From a translational perspective, organoid systems provide exciting new prospects for drug discovery, offering the possibility to perform compound screening in a three-dimensional (3D) human tissue context that resembles the native histoarchitecture and to some extent recapitulates cellular interactions. However, inherent variability issues and a general lack of robust quantitative technologies for analyzing organoids on a large scale pose severe limitations for their use in translational applications. To address this need, we have developed a screening platform that enables accurate quantification of fluorescent reporters in complex human iPSC-derived retinal organoids. This platform incorporates a fluorescence microplate reader that allows xyz-dimensional detection and fine-tuned wavelength selection. We have established optimal parameters for fluorescent reporter signal detection, devised methods to compensate for organoid size variability, evaluated performance and sensitivity parameters, and validated this technology for functional applications.

Background Increasingly, people diagnosed with cancer are surviving and continuing to participate in the work force. This trend brings with it new issues regarding survivors' employment-related needs. Objective The research team's objective is to explore cancer survivors' employment-related needs and supports with the ultimate goal of developing a training intervention for them. Methods Data were collected via an online survey. This article reports on the findings from the pilot stage of the study, which included 32 respondents. Results Many cancer survivors experience cancer symptoms at work, but do not tend to seek reasonable accommodations. Levels of awareness of possible programmatic and legal supports are low. Respondents reported that neither employers nor medical practitioners are primary sources of information regarding their individual employment-related concerns. Instead, they relied on general information from cancer advocacy organizations. Conclusions Survivors, employers, and practitioners who treat cancer patients could benefit from training resources about how survivors might address their employment-related needs.

A study of fusion-evaporation and (partly) fusion-fission channels for the $^{88}$Mo compound nucleus, produced at different excitation energies in the reaction $^{48}$Ti + $^{40}$Ca at 300, 450 and 600 MeV beam energies, is presented. Fusion-evaporation and fusion-fission cross sections have been extracted and compared with the existing systematics. Experimental data concerning light charged particles have been compared with the prediction of the statistical model in its implementation in the Gemini++ code, well suited even for high spin systems, in order to tune the main model parameters in a mass region not abundantly covered by exclusive experimental data. Multiplicities for light charged particles emitted in fusion evaporation events are also presented. Some discrepancies with respect to the prediction of the statistical model have been found for forward emitted $\alpha$-particles; they may be due both to pre-equilibrium emission and to reaction channels (such as Deep Inelastic Collisions, QuasiFission/QuasiFusion) different from the compound nucleus formation., Comment: 14 pages, 14 figures