51. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
- Author
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Haley Hunter-Zinck, Joel Gelernter, Mihaela Aslan, Saiju Pyarajan, John Concato, Frederick G. Sayward, Robert H. Pietrzak, J. Michael Gaziano, Quan Chen, Julien Bryois, Ning Sun, Yiming Hu, Million Veteran Program, Boyang Li, Daniel F. Levey, Krishnan Radhakrishnan, Yunling Shi, Nallakkandi Rajeevan, Yuli Li, Qiongshi Lu, Renato Polimanti, Kelly M. Harrington, Murray B. Stein, Kei-Hoi Cheung, Kelly Cho, Rachel Quaden, Patrick F. Sullivan, and Hongyu Zhao
- Subjects
Adult ,Male ,0301 basic medicine ,Veterans Health ,High linkage disequilibrium ,Genome-wide association study ,Article ,Cohort Studies ,Stress Disorders, Post-Traumatic ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Genetic Predisposition to Disease ,Genetic risk ,Veterans ,African american ,General Neuroscience ,Traumatic stress ,Biobank ,United States ,030104 developmental biology ,Cohort ,Female ,Neuroscience ,030217 neurology & neurosurgery ,Genome-Wide Association Study ,Cohort study ,Clinical psychology - Abstract
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P
- Published
- 2019