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52. Mucosal injury of small intestine in patients with advanced gastric cancer who developed chemotherapy induced diarrhea (CID).

Author

Sakumura, Miho, primary, Ando, Takayuki, additional, Hosokawa, Ayumu, additional, Mihara, Hiroshi, additional, Takagi, Hiroaki, additional, Yoshita, Hiroki, additional, Nanjo, Sohachi, additional, Ueda, Akira, additional, Fujinami, Haruka, additional, Kajiura, Shinya, additional, Ogawa, Kohei, additional, and Sugiyama, Toshiro, additional

Published
2018
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53. Baseline factors associated with acute progression of metastatic lesions after primary tumor resection in patients with unresectable colorectal cancer.

Author

Akashi, Momoko, primary, Ando, Takayuki, additional, Hosokawa, Ayumu, additional, Yoshita, Hiroki, additional, Nanjyo, Sohachi, additional, Ueda, Akira, additional, Mihara, Hiroshi, additional, Fujinami, Haruka, additional, Kajiura, Shinya, additional, Ogawa, Kohei, additional, and Sugiyama, Toshiro, additional

Published
2018
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56. Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.

Author

Mihara, Hiroshi, Boudaka, Ammar, Tominaga, Makoto, and Sugiyama, Toshiro

Subjects
*ADENOSINE triphosphate, *VISCERAL pain, *SECRETORY granules, *EPOXYEICOSATRIENOIC acids, *EXOCYTOSIS, *INFLAMMATION
Abstract

Background: Transient receptor potential vanilloid 4 (TRPV4) is activated by stretch (mechanical), warm temperature, some epoxyeicosatrienoic acids, and lipopolysaccharide. TRPV4 is expressed throughout the gastrointestinal epithelia and its activation induces adenosine triphosphate (ATP) exocytosis that is involved in visceral hypersensitivity. As an ATP transporter, vesicular nucleotide transporter (VNUT) mediates ATP storage in secretory vesicles and ATP release via exocytosis upon stimulation. Summary: TRPV4 is sensitized under inflammatory conditions by a variety of factors, including proteases and serotonin, whereas methylation-dependent silencing of TRPV4 expression is associated with various pathophysiological conditions. Gastrointestinal epithelia also release ATP in response to hypo-osmolality or acid through molecular mechanisms that remain unclear. These synergistically released ATP could be involved in visceral hypersensitivity. Low concentrations of the first generation bisphosphate, clodronate, were recently reported to inhibit VNUT activity and thus clodronate may be a safe and potent therapeutic option to treat visceral pain. Key Messages: This review focuses on: (1) ATP and TRPV4 activities in gastrointestinal epithelia; (2) factors that could modulate TRPV4 activity in gastrointestinal epithelia; and (3) the inhibition of VNUT as a potential novel therapeutic strategy for functional gastrointestinal disorders. [ABSTRACT FROM AUTHOR]

Published
2020
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61. The Practice Guidelines for Primary Care of Acute Abdomen 2015

Author

Mayumi, Toshihiko, primary, Yoshida, Masahiro, additional, Tazuma, Susumu, additional, Furukawa, Akira, additional, Nishii, Osamu, additional, Shigematsu, Kunihiro, additional, Azuhata, Takeo, additional, Itakura, Atsuo, additional, Kamei, Seiji, additional, Kondo, Hiroshi, additional, Maeda, Shigenobu, additional, Mihara, Hiroshi, additional, Mizooka, Masafumi, additional, Nishidate, Toshihiko, additional, Obara, Hideaki, additional, Sato, Norio, additional, Takayama, Yuichi, additional, Tsujikawa, Tomoyuki, additional, Fujii, Tomoyuki, additional, Miyata, Tetsuro, additional, Maruyama, Izumi, additional, Honda, Hiroshi, additional, and Hirata, Koichi, additional

Published
2016
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62. Phase I Study of Docetaxel Plus Nedaplatin in Patients With Metastatic or Recurrent Esophageal Squamous Cell Carcinoma After Cisplatin Plus 5-Fluorouracil Treatment

Author

Kajiura, Shinya, primary, Hosokawa, Ayumu, additional, Yoshita, Hiroki, additional, Ueda, Yuko, additional, Ueda, Akira, additional, Mihara, Hiroshi, additional, Ando, Takayuki, additional, Fujinami, Haruka, additional, Nishikawa, Jun, additional, Ogawa, Kohei, additional, Minemura, Masami, additional, and Sugiyama, Toshiro, additional

Published
2016
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64. Practice Guidelines for Primary Care of Acute Abdomen 2015

Author

Mayumi, Toshihiko, primary, Yoshida, Masahiro, additional, Tazuma, Susumu, additional, Furukawa, Akira, additional, Nishii, Osamu, additional, Shigematsu, Kunihiro, additional, Azuhata, Takeo, additional, Itakura, Atsuo, additional, Kamei, Seiji, additional, Kondo, Hiroshi, additional, Maeda, Shigenobu, additional, Mihara, Hiroshi, additional, Mizooka, Masafumi, additional, Nishidate, Toshihiko, additional, Obara, Hideaki, additional, Sato, Norio, additional, Takayama, Yuichi, additional, Tsujikawa, Tomoyuki, additional, Fujii, Tomoyuki, additional, Miyata, Tetsuro, additional, Maruyama, Izumi, additional, Honda, Hiroshi, additional, and Hirata, Koichi, additional

Published
2015
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65. The Practice Guidelines for Primary Care of Acute Abdomen 2015

Author

Mayumi, Toshihiko, primary, Yoshida, Masahiro, additional, Tazuma, Susumu, additional, Furukawa, Akira, additional, Nishii, Osamu, additional, Shigematsu, Kunihiro, additional, Azuhata, Takeo, additional, Itakura, Atsuo, additional, Kamei, Seiji, additional, Kondo, Hiroshi, additional, Maeda, Shigenobu, additional, Mihara, Hiroshi, additional, Mizooka, Masafumi, additional, Nishidate, Toshihiko, additional, Obara, Hideaki, additional, Sato, Norio, additional, Takayama, Yuichi, additional, Tsujikawa, Tomoyuki, additional, Fujii, Tomoyuki, additional, Miyata, Tetsuro, additional, Maruyama, Izumi, additional, Honda, Hiroshi, additional, and Hirata, Koichi, additional

Published
2015
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68. Transient receptor potential vanilloid 4 ( TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium.

Author

Mihara, Hiroshi, Suzuki, Nobuhiro, Muhammad, Jibran Sualeh, Nanjo, Sohachi, Ando, Takayuki, Fujinami, Haruka, Kajiura, Shinya, Hosokawa, Ayumu, and Sugiyama, Toshiro

Subjects
*HELICOBACTER pylori infections, *EPITHELIUM, *TRP channels, *TRPV cation channels, *LUCIFERASES, *MESSENGER RNA, *DNA
Abstract

Background Helicobacter pylori ( HP) infection induces methylation silencing of specific genes in gastric epithelium. Various stimuli activate the nonselective cation channel TRPV4, which is expressed in gastric epithelium where it detects mechanical stimuli and promotes ATP release. As CpG islands in TRPV4 are methylated in HP-infected gastric epithelium, we evaluated HP infection-dependent changes in TRPV4 expression in gastric epithelium. Materials and Methods Human gastric biopsy samples, a human gastric cancer cell line ( AGS), and a normal gastric epithelial cell line ( GES-1) were used to detect TRPV4 mRNA and protein expression by RT- PCR and Western blotting, respectively. Ca2+ imaging was used to evaluate TRPV4 ion channel activity. TRPV4 methylation status was assessed by methylation-specific PCR ( MSP). ATP release was measured by a luciferin-luciferase assay. Results TRPV4 mRNA and protein were detected in human gastric biopsy samples and in GES-1 cells. MSP and demethylation assays showed TRPV4 methylation silencing in AGS cells. HP coculture directly induced methylation silencing of TRPV4 in GES-1 cells. In human samples, HP infection was associated with TRPV4 methylation silencing that recovered after HP eradication in a time-dependent manner. Conclusion HP infection-dependent DNA methylation suppressed TRPV4 expression in human gastric epithelia, suggesting that TRPV4 methylation may be involved in HP-associated dyspepsia. [ABSTRACT FROM AUTHOR]

Published
2017
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71. Multiple Colon Ulcers with Typical Small Intestinal Lesions Induced by Non-Steroidal Anti-Inflammatory Drugs

Author

Akashi, Momoko, primary, Ando, Takayuki, additional, Hamashima, Takeru, additional, Yoshita, Hiroki, additional, Nanjo, Sohachi, additional, Mihara, Hiroshi, additional, Fujinami, Haruka, additional, Kajiura, Shinya, additional, Nishikawa, Jun, additional, Miura, Yoshiaki, additional, Hosokawa, Ayumu, additional, and Sugiyama, Toshiro, additional

Published
2015
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72. The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia

Author

Aijima, Reona, primary, Wang, Bing, additional, Takao, Tomoka, additional, Mihara, Hiroshi, additional, Kashio, Makiko, additional, Ohsaki, Yasuyoshi, additional, Zhang, Jing‐Qi, additional, Mizuno, Atsuko, additional, Suzuki, Makoto, additional, Yamashita, Yoshio, additional, Masuko, Sadahiko, additional, Goto, Masaaki, additional, Tominaga, Makoto, additional, and Kido, Mizuho A., additional

Published
2014
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76. Immune-mediated Protein-losing Enteropathy with Down Syndrome

Author

Nanjo, Sohachi, primary, Nishikawa, Jun, additional, Miwa, Shigeharu, additional, Mihara, Hiroshi, additional, Fujinami, Haruka, additional, Yoshita, Hiroki, additional, Ueda, Akira, additional, Kajiura, Shinya, additional, Hasumoto, Yushi, additional, Ando, Takayuki, additional, Hosokawa, Ayumu, additional, and Sugiyama, Toshiro, additional

Published
2014
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79. Su2081 Silencing of Transient Receptor Potential Vanilloid 4 (TRPV4) in Gastric Epithelium With Its Methylation Could Affect Gastric Emptying in H. pylori Infected Individuals

Author

Mihara, Hiroshi, primary, Suzuki, Nobuhiro, additional, Ueda, Yuko, additional, Nanjo, Sohachi, additional, Ando, Takayuki, additional, Nishikawa, Jun, additional, Fujinami, Haruka, additional, Hosokawa, Ayumu, additional, Tominaga, Makoto, additional, and Sugiyama, Toshiro, additional

Published
2013
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80. Early decline of CA125 to chemotherapy in advanced gastric cancer with peritoneal effusion.

Author

Ando, Takayuki, primary, Hosokawa, Ayumu, additional, Ueda, Yuko, additional, Yoshita, Hiroki, additional, Ueda, Akira, additional, Mihara, Hiroshi, additional, Hasumoto, Yuushi, additional, Fujinami, Haruka, additional, Kajiura, Shinya, additional, Nishikawa, Jun, additional, Ogawa, Kohei, additional, Tsukioka, Yuji, additional, Kobayashi, Takashi, additional, Horikawa, Naoki, additional, and Sugiyama, Toshiro, additional

Published
2013
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82. Preventive effect of rikkunshito, traditional Japanese medicine, for chemotherapy-induced nausea and vomiting.

Author

Kajiura, Shinya, primary, Hosokawa, Ayumu, additional, Nanjyo, Sohachi, additional, Yoshita, Hiroki, additional, Suzuki, Nobuhiro, additional, Yamawaki, Hidemoto, additional, Ueda, Yuko, additional, Ueda, Akira, additional, Mihara, Hiroshi, additional, Hasumoto, Yuushi, additional, Ando, Takayuki, additional, Fujinami, Haruka, additional, Nishikawa, Jun, additional, Ogawa, Kohei, additional, and Sugiyama, Toshiro, additional

Published
2013
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86. Irinotecan Plus Mitomycin C as Second-Line Chemotherapy for Advanced Gastric Cancer Resistant to Fluoropyrimidine and Cisplatin: A Retrospective Study

Author

Ogawa, Kohei, primary, Hosokawa, Ayumu, additional, Ueda, Akira, additional, Saito, Seiko, additional, Mihara, Hiroshi, additional, Ando, Takayuki, additional, Kajiura, Shinya, additional, Terada, Mitsuhiro, additional, Tsukioka, Yuji, additional, Horikawa, Naoki, additional, Kobayashi, Takashi, additional, Note, Masayuki, additional, Sawasaki, Kunihiro, additional, Fukuoka, Junya, additional, and Sugiyama, Toshiro, additional

Published
2012
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92. Amrubicin Monotherapy for Patients with Platinum-Refractory Gastroenteropancreatic Neuroendocrine Carcinoma.

Author

Ando, Takayuki, Hosokawa, Ayumu, Yoshita, Hiroki, Ueda, Akira, Kajiura, Shinya, Mihara, Hiroshi, Nanjo, Sohachi, Fujinami, Haruka, Nishikawa, Jun, Ogawa, Kohei, Nakajima, Takahiko, Imura, Johji, and Sugiyama, Toshiro

Subjects
CANCER patients, PANCREATIC cancer, NEUROENDOCRINE tumors, CANCER chemotherapy, GASTROENTEROLOGY, NEUTROPENIA, PROGRESSION-free survival, PROGNOSIS
Abstract

Objective. Patients with gastroenteropancreatic neuroendocrine carcinoma (NEC) have a poor prognosis. Platinum-based combination chemotherapy is commonly used as first-line treatment; however, the role of salvage chemotherapy remains unknown. This study aimed to analyze the efficacy and safety of amrubicin monotherapy in patients with platinum-refractory gastroenteropancreatic NEC. Methods. Among 22 patients with advanced gastroenteropancreatic NEC, 10 received amrubicin monotherapy between September 2007 and May 2014 after failure of platinum-based chemotherapy. The efficacy and toxicity of the treatment were analyzed retrospectively. Results. Eight males and two females (median age, 67 years (range, 52–78)) received platinum-based chemotherapy, including cisplatin plus irinotecan (n=7, 70%), cisplatin plus etoposide (n=2, 20%), and carboplatin plus etoposide (n=1, 10%) before amrubicin therapy. Median progression-free survival and overall survival after amrubicin therapy were 2.6 and 5.0 months, respectively. Two patients had partial response (20% response rate), and their PFS were 6.2 months and 6.3 months, respectively. Furthermore, NEC with response for amrubicin had characteristics with a high Ki-67 index and receipt of prior chemotherapy with cisplatin and irinotecan. Grade 3-4 neutropenia and anemia were observed in four and five patients, respectively. Conclusion. Amrubicin monotherapy appears to be potentially active and well-tolerated for platinum-refractory gastroenteropancreatic NEC. [ABSTRACT FROM AUTHOR]

Published
2015
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93. Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide

Author

Abe, Toshinori, primary, Aikawa, Tatsuya, additional, Akahane, Yoshihiro, additional, Arai, Masahiro, additional, Asahina, Yasuhiro, additional, Atarashi, Yoshinari, additional, Chayama, Kazuaki, additional, Harada, Hideharu, additional, Hashimoto, Naoaki, additional, Hori, Akiko, additional, Ichida, Takafumi, additional, Ikeda, Hiroki, additional, Ishikawa, Akihisa, additional, Ito, Takayoshi, additional, Kang, Jong-Hon, additional, Karino, Yoshiyasu, additional, Kato, Hideaki, additional, Kato, Masaru, additional, Kawakami, Mari, additional, Kitajima, Naoto, additional, Kitamura, Tsuneo, additional, Masaki, Naohiko, additional, Matsubayashi, Keiji, additional, Matsuda, Hiroyuki, additional, Matsui, Atsushi, additional, Michitaka, Kojiro, additional, Mihara, Hiroshi, additional, Miyaji, Katsuhiko, additional, Miyakawa, Hiroshi, additional, Mizuo, Hitoshi, additional, Mochida, Satoshi, additional, Moriyama, Mitsuhiko, additional, Nishiguchi, Shuhei, additional, Okada, Katsuo, additional, Saito, Hidetsugu, additional, Sakugawa, Hiroshi, additional, Shibata, Minoru, additional, Suzuki, Kazuyuki, additional, Takahashi, Kazuaki, additional, Yamada, Gotaro, additional, Yamamoto, Kazuhide, additional, Yamanaka, Taro, additional, Yamato, Hiroaki, additional, Yano, Koji, additional, and Mishiro, Shunji, additional

Published
2006
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94. Involvement of TRPV2 Activation in Intestinal Movement through Nitric Oxide Production in Mice.

Author

Mihara, Hiroshi, Boudaka, Ammar, Shibasaki, Koji, Yamanaka, Akihiro, Sugiyama, Toshiro, and Tominaga, Makoto

Subjects
*NITRIC oxide, *LABORATORY mice, *TRP channels, *PROBENECID (Drug), *LYSOPHOSPHOLIPIDS, *GASTROINTESTINAL system, *MOTOR neurons
Abstract

Transient receptor potential channel vanilloid 2 (TRPV2) can detect various stimuli such as temperature (>52°C), stretch, and chemicals, including 2-aminoethoxydiphenyl borate, probenecid, and lysophospholipids. Although expressed in many tissues, including sensory and motor neurons, TRPV2 expression and function in the gastrointestinal tract is poorly understood. Here, we show TRPV2 expression in the murine intestine and its involvement in intestinal function. Almost all mouse intestinal intrinsic sensory and inhibitory motor neurons, both cell bodies and nerve fibers, showed TRPV2 immunoreactivity. Several known TRPV2 activators increased cytosolic Ca2+ concentrations and evoked TRPV2-like current responses in dissociated myenteric neurons. Interestingly, mechanical stimuli activated inward currents in a strength-dependent manner, which were inhibited by a TRPV2 inhibitor tranilast. TRPV2 activation in isolated intestine inhibited spontaneous circular muscle contraction, which did not occur in the presence of the TRPV2 antagonist, tetrodotoxin or nitro oxide (NO) synthase pathway inhibitors. Also, increased intestinal NO production was observed in response to a TRPV2 agonist, and gastrointestinal transit in vivo was accelerated by TRPV2 agonists or an NO donor. In conclusion, TRPV2 may contribute to intestinal motility through NO production, and TRPV2 is a promising target for controlling intestinal movement. [ABSTRACT FROM AUTHOR]

Published
2010
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95. CEREBRAL ANGIOGRAPHIC STUDY ON C.V.D. IN JAPAN.

Author

Tomita, Takashi and Mihara, Hiroshi

Subjects
CEREBRAL angiography, ANGIOGRAPHY, CENTRAL nervous system diseases, CAUSES of death, CEREBROVASCULAR disease, BRAIN diseases
Abstract

1) Consecutive 1.107 patients with central nervous system vascular lesion were studied by means of four vessel angiography in Japan. 2) Complications of this series were rare, 2.8 per cent, mostly from technical failures, death and infection; causes of angiograpbic complication have not occurred. 3) The methods for prevention of cerebral angiographic complications have been discussed. 4) Findings of angiograpby are described; almost fifty per cent of these patients had cerebral arterial sclerosis only. 5) Some differences on finding of cerebral angiography were discovered, between the Japanese, American, and Danish. We have more cases with hemorrhagic diseases, but less cases with occlusive diseases, then the other countries. 6) We found many patients who required the surgical treatment in this series. 7) Shift of basilar artery itself, shift of bifurcation of basilar artery and window formation of vertebral artery with intracranial aneurysm were included in this preliminary report. Presented at the International College of Surgeons, XVI Biennial International Congress, Tokyo, Japan, October 7, 1968. [ABSTRACT FROM AUTHOR]

Published
1972
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