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The use of energy storage systems in standalone photovoltaic installations is essential to supply energy demands, independently of solar generation. Accurate prediction of the battery state is critical for the safe, durable, and reliable operation of systems in this type of installations. In this study, an installation located in the area of Aragon (Spain) has been considered. Two methods, based on different types of Recurrent Neural Networks (RNN), are proposed to predict the battery voltage of the installation two days ahead. Specifically, the Nonlinear Auto Regressive with Exogenous Input (NARX) network and the Long Short-Term Memory (LSTM) network are studied and compared. The implemented algorithms process battery voltage, temperature and current waveforms; and rely on the selection of different future scenarios based on weather forecasting to estimate the future voltage of the battery. The proposed methodology is capable of predicting the voltage with a Root Mean Squared Error (RMSE) error of 1.2 V for batteries of 48 V, in critical situations where the installation is running out of energy. The study contributes to the ongoing research of developing preventive control systems that help reduce costs and improve the performance of remote energy storage systems based on renewable energies with a positive outcome.

Resumen Este documento de posicionamiento, auspiciado por la Asociacion Espanola de Gastroenterologia, la Sociedad Espanola de Endoscopia Digestiva y la Sociedad Espanola de Anatomia Patologica, tiene como objetivo establecer recomendaciones para el cribado del cancer gastrico (CG) en poblaciones con incidencia baja, como la espanola. Para establecer la calidad de la evidencia y los niveles de recomendacion se ha utilizado la metodologia basada en el sistema GRADE (Grading of Recommendations Assessment, Development and Evaluation). Se obtuvo el consenso entre expertos mediante un metodo Delphi. El documento evalua el cribado en poblacion general, individuos con familiares con CG y lesiones precursoras de CG (LPCG). El objetivo de las intervenciones debe ser la reduccion de la mortalidad por CG. Se recomienda el uso de la clasificacion OLGIM y determinar el subtipo de metaplasia intestinal (MI) para evaluar las LPCG. No se recomienda establecer cribado poblacional endoscopico de CG ni de Helicobacter pylori. Sin embargo, el documento establece una recomendacion fuerte para el tratamiento de H. pylori si se detecta la infeccion, y su investigacion y tratamiento en individuos con antecedentes familiares de CG o con LPCG. En cambio, no se recomienda el uso de test serologicos para detectar LPCG. Se sugiere cribado endoscopico unicamente en los individuos con criterios de CG familiar. En cuanto a los individuos con LPCG, solo se sugiere vigilancia endoscopica ante MI extensa asociada a algun factor de riesgo adicional (MI incompleta y/o antecedentes familiares de CG) tras la reseccion de lesiones displasicas o en pacientes con displasia sin lesion visible tras una endoscopia digestiva alta de calidad con cromoendoscopia.

This paper studies how two recent neo-slave narratives have been translated into Spanish: The Good Lord Bird, by James McBride, and The Underground Railroad, by Colson Whitehead. Since they were both published simultaneously in Spain in September 2017, special attention is paid to the strategies used to render Black English, which marks slaves’ otherness, in the target polysystem. An overview of the origin, rise, and evolution of neo-slave narratives precedes the features of African-American Vernacular English portrayed in the novels that belong to this sub-genre. After some insights into the issue of translating literary dialect, the risks it entails, and the different strategies that can be used, the Spanish versions of McBride’s and Whitehead’s works are analyzed accordingly and contrasted.

Producción Científica, We report a state-of-the-art spectroscopic study of an archetypical barbaralone, conclusively revealing the valence tautomerism phenomena for this bistable molecular system. The two distinct 1- and 5-substituted valence tautomers have been isolated in a supersonic expansion for the first time and successfully characterized by high-resolution rotational spectroscopy. This work provides irrefutable experimental evidence of the [3,3]-rearrangement in barbaralones and highlights the use of rotational spectroscopy to analyze shape-shifting mixtures. Moreover, this observation opens the window toward the characterization of new fluxional systems in the isolation conditions of the gas phase and should serve as a reference point in the general understanding of valence tautomerism., Ministerio de Ciencia e Innovación y Agencia Estatal de Investigación (grants MCIN/A EI/10.13039/ 501100011 033, PID2019-111396GB-I00, PID2019-104815GB-I00, CEX2019-000925-S), Junta de Castilla y Leon (projects VA077U16 and VA244P20), Agencia de Gestión de Ayudas Universitarias y de Investigación y el Programa CERCA/Generalitat de Catalunya de apoyo financiero (2017 SGR 1257), Ministerio de Ciencia, Innovación y Universidades (grant FPU17/02987)

The continuous flow, enantioselective, organophotoredox catalytic asymmetric alkylation of aldehydes was studied, by using a homemade, custom-designed photoreactor for reactions under cryogenic conditions. Going from microfluidic conditions up to a 10 mL mesofluidic reactor, an increase of productivity by almost 18000 % compared to the batch reaction was demonstrated. Finally, for the first time, a stereoselective photoredox organocatalytic continuous flow reaction in a fully telescoped process for an active pharmaceutical ingredient (API)synthesis was successfully achieved. The final process consists of four units of operation: visible light-driven asymmetric catalytic benzylation under continuous flow, inline continuous work-up, neutralisation and a final oxidative amidation step afforded the pharmaceutically active molecule in 95 % e.e.

The Convention for the Protection of the Architectural Heritage of Europe, adopted in 1985, constitutes the doctrinal core of the protection and conservation of the Architectural Heritage at an international level. Spain ratifies the Convention in 1989, after the approval of Law 16/1985 of the Spanish Historical Heritage adhering to the international legal framework. In the context of the autonomous state, since the 1990s all the Autonomous Communities have gradually adopted their own Cultural Heritage laws. The present study analyses the State’s law and the Autonomous laws of the Basque Country and Canary Islands, focusing on two of the aspects in which the Convention sets guidelines: the definition of Architectural Heritage and the identification of the assets subject to protection.

La Convención para la Salvaguarda del Patrimonio Arquitectónico de Europa, aprobada en 1985, constituye el núcleo doctrinal de la protección y conservación del Patrimonio Arquitectónico a nivel internacional. España ratifica la Convención en el año 1989, tras la aprobación de la Ley 16/1985 del Patrimonio Histórico Español con la que se adapta al marco jurídico internacional. En el contexto del estado autonómico, desde los años 90 todas las Comunidades Autónomas han aprobado gradualmente sus propias leyes de Patrimonio Cultural. El presente estudio analiza la ley estatal y las recién aprobadas leyes autonómicas del País Vasco y Canarias, centrado en dos aspectos en los que la Convención marca unas directrices: la definición de Patrimonio Arquitectónico y la identificación de los bienes objeto de protección. ----------ABSTRACT---------- The Convention for the Protection of the Architectural Heritage of Europe, adopted in 1985, constitutes the doctrinal core of the protection and conservation of the Architectural Heritage at an international level. Spain ratifies the Convention in 1989, after the approval of Law 16/1985 of the Spanish Historical Heritage adhering to the international legal framework. In the context of the autonomous state, since the 1990s all the Autonomous Communities have gradually adopted their own Cultural Heritage laws. The present study analyses the State’s law and the Autonomous laws of the Basque Country and Canary Islands, focusing on two of the aspects in which the Convention sets guidelines: the definition of Architectural Heritage and the identification of the assets subject to protection. ----------RESUMO---------- A Convenção para a Salvaguarda do Património Arquitetónico da Europa, aprovada em 1985, constitui o núcleo doutrinário da proteção e conservação do Património Arquitetónico a nível internacional. A Espanha ratifica a Convenção em 1989, após a aprovação da Lei 16/1985 sobre o Património Histórico Espanhol, com a qual se adapta ao quadro jurídico internacional. No contexto do estado autónomo, desde os anos 90, todas as comunidades autónomas passaram gradualmente as suas próprias leis de Património Cultural. O presente estudo analisa a lei estadual e as leis autónomas recentemente aprovadas do País Basco e das Ilhas Canárias, concentrando-se em dois aspetos nos quais a Convenção estabelece diretrizes: a definição de Património Arquitetónico e a identificação dos bens sujeitos à proteção.

Herein, we report the first rotational study of neutral L-DOPA, an extensively used supramolecular synthon and an amino acid precursor of the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) using broadband and narrowband Fourier transform microwave spectroscopies coupled with a laser ablation vaporization system. The spectroscopic parameters derived from the analysis of the rotational spectrum conclusively identify the existence of four distinct conformers of L-DOPA in the supersonic jet, further rejecting the previously reported catechol ring-induced conformational restriction. The analysis of the

Herein we present a laboratory rotational study of cyanoacetic acid (CH2(CN)C(O)OH), an organic acid as well as a -CN bearing molecule, that is a candidate molecular system to be detected in the interstellar medium (ISM). Our investigation aims to provide direct experimental frequencies of cyanoacetic acid to guide its eventual astronomical search in low-frequency surveys. Using different jet-cooled rotational spectroscopic techniques in the time domain, we have determined a precise set of the relevant rotational spectroscopic constants, including the 14N nuclear quadrupole coupling constants for the two distinct structures, cis- and gauche- cyanoacetic acid. We believe this work will potentially allow the detection of cyanoacetic acid in the interstellar medium, whose rotational features have remained unknown until now., The authors thank the financial funding from Ministerio de Ciencia e Innovación (CTQ2016-76393-P and PID2019-111396GB-I00), Junta de Castilla y Leon (VA077U16 and VA244P20), and European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC-2013-SyG, grant agreement No. 610256 NANOCOSMOS. E.R.A. thanks Ministerio de Ciencia, Innovacion y Universidades for Juan de la Cierva grant (FJC2018-037320-I). M.S.N. acknowledges funding from the Spanish "Ministerio de Ciencia, Innovacion y Universidades" under predoctoral FPU Grant (FPU17/02987).

En este trabajo se expone una experiencia diseñada para dar respuesta a los bajos niveles de implementación de las actividades en el medio natural en los colegios del barrio de Las Delicias en la ciudad de Zaragoza. El coste económico de las actividades y la falta de infraestructuras y materiales son los factores que más limitan a los maestros de Educación Física para poder incorporar estos contenidos en sus centros. La experiencia presentada tiene por objetivo superar estas dificultades. De este modo, queda constituida por dos apartados: en primer lugar, la construcción de un rocódromo a bajo coste. En segundo lugar, una unidad didáctica de ocho sesiones. Las actividades presentadas favorecen un uso responsable del rocódromo, favoreciendo la autonomía del alumnado en la iniciación a este deporte, pasando por los roles de escalador, asegurador y guía. La propuesta ha tenido gran acogida en el centro, implicando también a docentes del área de Educación Infantil en la decoración de la nueva infraestructura.Abstract: This paper presents an experience designed to address the low levels of implementation of outdoor activities in schools in ‘Las Delicias’ neighborhood, Zaragoza. The (high) cost of these activities and the lack of equipment and facilities are the main limitations that Physical Education teachers face when they try to carry them out in schools. The main objective of the experience we present is to overcome the aforementioned difficulties. To this end, it consists of two parts: firstly, the construction of a low-cost climbing wall. Secondly, the development of an eight-session teaching unit that will take place using the aforesaid climbing wall. These actions promote a responsible use of the climbing wall as well as the autonomy of the students through their introduction to this sport, where they will be requested to take the roles of climber, insurer, and guide.

Producción Científica, Enantioenriched 3‐amino‐3‐substituted oxindoles have been obtained by addition of different nucleophiles to N‐Boc ketimines derived from isatin catalyzed by chiral bifunctional supported thioureas. The Mannich reaction occurs with excellent enantioselection, but poor diastereoselection when prochiral nucleophiles were used. The supported catalyst were recovered and reused for five times without loss of activity. The mixture of diastereoisomers formed when a prochiral structure was used as nucleophile was converted into a single enantioenriched pyrazolyl derivative., Ministerio de Economía, Industria y Competitividad (Project FEDER-CTQ2014–59870-P), Junta de Castilla y León (Projects FEDER-VA115P17 / VA149G18)

Herein, we report a computational investigation of the binding affinity of dexamethasone, betamethasone, chloroquine and hydroxychloroquine to SARS-CoV-2 main protease using molecular and quantum mechanics as well as molecular docking methodologies. We aim to provide information on the anti-COVID-19 mechanism of the abovementioned potential drugs against SARS-CoV-2 coronavirus. Hence, the 6w63 structure of the SARS-CoV-2 main protease was selected as potential target site for the docking analysis. The study includes an initial conformational analysis of dexamethasone, betamethasone, chloroquine and hydroxychloroquine. For the most stable conformers, a spectroscopic analysis has been carried out. In addition, global and local reactivity indexes have been calculated to predict the chemical reactivity of these molecules. The molecular docking results indicate that dexamethasone and betamethasone have a higher affinity than chloroquine and hydroxychloroquine for their theoretical 6w63 target. Additionally, dexamethasone and betamethasone show a hydrogen bond with the His41 residue of the 6w63 protein, while the interaction between chloroquine and hydroxychloroquine with this amino acid is weak. Thus, we confirm the importance of His41 amino acid as a target to inhibit the SARS-CoV-2 Mpro activity.

Implementation of policies to reduce CO2 emissions relies on an increasing prominence of renewable energies. However, application of renewable energy sources also poses challenges. As these energy sources fluctuate during time, it is necessary to develop methods to store the produced energy. Hydrogen is a promising material for chemical storage, but storage of hydrogen is a challenging task as requirements of storage capacity, release kinetics and weight must be met. Extensive research on solid hydrogen storage materials has been carried out in order to accomplish these objectives. Metallic and chemical hydrides are among the most promising storage materials, but they are still limited by thermodynamic and kinetic properties. Nanoconfinement of hydrides in mesoporous or microporous compounds has been proposed as a method to overcome these limitations using supercritical fluids as technique to control the particle sizes. In this work, the main results reported in this expanding research field are reviewed.

Producción Científica, Context. Cyanoacetamide is a –CN bearing molecule that is also an amide derivative target molecule in the interstellar medium. Aims. The aim of our investigation is to analyze the feasibility of a plausible formation process of protonated cyanoacetamide under interstellar conditions and to provide direct experimental frequencies of the ground vibrational state of the neutral form in the microwave region in order to enable its eventual identification in the interstellar medium. Methods. We used high-level theoretical computations to study the formation process of protonated cyanoacetamide. Furthermore, we employed a high-resolution laser-ablation molecular beam Fourier transform spectroscopic technique to measure the frequencies of the neutral form. Results. We report the first rotational characterization of cyanoacetamide, and a precise set of the relevant rotational spectroscopic constants have been determined as a first step to identifying the molecule in the interstellar medium. We fully explored the potential energy surface to study a gas-phase reaction on the formation process of protonated cyanoacetamide. We found that an exothermic process with no net activation barrier is initiated by the high-energy isomer of protonated hydroxylamine, which leads to protonated cyanoacetamide., Ministerio de Ciencia, Innovación y Universidades (Project CTQ2016-76393-P), Ministerio de Economía, Industria y Competitividad (Grant AYA2017-87515-P), Junta de Castilla y León (Grants VA077U16 and Grant VA010G18), European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC-2013- SyG, Grant Agreement no. 610 256 NANOCOSMOS

Objective and Outcomes Measures: Our aim was to characterize the population of patients diagnosed with AML who were attended in 7 health institutions in Colombia, from 2009 to 2020, included based on RENEHOC (online platform) and PETHEMA (Spanish Program for Hematology Treatments). Kaplan-Meier analysis was used to assess overall survival at 1 year (1-OS) and 5 years (5-OS) of follow-up and relapse-free survival (1-RFS, 5-RFS). Results: A total of 289 patients were included; almost half (50.2%) were female, and the median age at diagnosis was 62 years old (14–95). Most patients were ECOG 1 (39.3%) and ECOG 2 (38.8%). The patients (12.5%) presented with secondary AML, and 0.3% had hereditary predisposition syndromes to AML (Down syndrome). Complete remission was achieved in 45.0% of patients, 17.8% absolute resistance, and 13.6% patients died in induction, the majority after day 15 (66.7%). Most of the patients received intensive chemotherapy 7+3 induction regimen (55.8%). Hematopoietic stem cell transplantation (HSCT) was a treatment option for 21.2% of patients, and 77.4% met criteria for HSCT. Allogeneic HSCT (alloTPH) was performed in 19% and autologous HSCT (autoTPH) in 2.2%. The survival at 1-OS and 5-OS was 56.1% (95%CI 48.0–63.4) and 26.7% (95%CI 18.1–36.1), respectively. The RFS was 56.6% (95%CI 48.4–64.0) at 1-year and 22.2% (95%CI 14.0–31.6) at 5-years. For patients younger than 65 years ( Conclusion: Our results also show AML in an older population and that age is associated with shorter survival. We identified a low proportion of AlloHSCT, despite the survival benefit compared to non-transplant patients.

Context: Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Objective: To determine the OS of patients diagnosed with AML according to the type of AML, de novo (n-AML) or secondary (s-AML), in the Clinica Foscal, a university hospital in Colombia during 2013–2020. Results: A total of 157 patients were registered; 50.3% were male; the median age at the time of diagnosis was 58.8 years (range: 18–95); for n-AML median age was 57.4 years (range: 18–95), and 62.3 years (range: 26–84) for s-AML. Regarding the etiology of AML, 75.2% presented n-AML and 24.8% s-AML, distributed as follows: 23.1% secondary to chronic myeloproliferative neoplasms, 10.3% to therapy, and 4% to myelodysplasia. In patients with n-AML, 74.3% were classified as ECOG Conclusions: Our results demonstrated worse outcomes for patients with s-AML compared with patients with n-AML. It is important to identify s-AML patients and review their genetic and molecular expressions, so a directed treatment can be offered with major effectivity and early allogeneic transplant.

Context: The overall survival (OS) of acute myeloid leukemia (AML) decreases as age increases among patients. Studies have shown that several factors, such as socioeconomic and demographic factors, are associated with worse OS outcomes among patients. Objective: To determine the OS of patients diagnosed with AML according to age: under 65 years ( 65) at Clinica FOSCAL, a University Hospital in Colombia, during 2013–2020. Results: A total of 157 patients were registered, with a median age at the time of diagnosis of 58.8 years (range: 18–95). Regarding age, 57.2% of patients were 65. The OS in patients Conclusion: As has been shown in other studies, our analyses agree and show a decrease in survival in older patients (≥65 years). It is important to recognize older adult patients with these pathologies to evaluate treatment strategies with new alternatives with which better responses can be achieved with less toxicity.

During live events the organizers often would want to deploy audience engagement systems to analyze people behaviour, perform user profiling or modify the show according to the participant feedback. Such systems usually need computer vision algorithms whose performance are severely affected by constraints such as illumination and cameras position. In this paper we present a fully automatic audience engagement system, optimized for live music events with rapidly changing illumination conditions. The system uses a multi-modal approach which combines wireless-based person detection together with computer vision algorithms for pose and face analysis. We show that such hybrid approach, while running in real-time, performs better than standard approaches that only employ computer vision techniques. The system has been tested both in a laboratory environment as well as in a concert hall and it will be deployed in distributed live events.

This paper presents a fault detection system for photovoltaic standalone applications based on Gaussian Process Regression (GPR). The installation is a communication repeater from the Confederación Hidrográfica del Ebro (CHE), public institution which manages the hydrographic system of Aragón, Spain. Therefore, fault-tolerance is a mandatory requirement, complex to fulfill since it depends on the meteorology, the state of the batteries and the power demand. To solve it, we propose an online voltage prediction solution where GPR is applied in a real and large dataset of two years to predict the behavior of the installation up to 48 hour. The dataset captures electrical and thermal measures of the lead-acid batteries which sustain the installation. In particular, the crucial aspect to avoid failures is to determine the voltage at the end of the night, so different GPR methods are studied. Firstly, the photovoltaic standalone installation is described, along with the dataset. Then, there is an overview of GPR, emphasizing in the key aspects to deal with real and large datasets. Besides, three online recursive multistep GPR model alternatives are tailored, justifying the selection of the hyperparameters: Regular GPR, Sparse GPR and Multiple Experts (ME) GPR. An exhaustive assessment is performed, validating the results with those obtained by Long Short-Term Memory (LSTM) and Nonlinear Autoregressive Exogenous Model (NARX) networks. A maximum error of 127 mV and 308 mV at the end of the night with Sparse and ME, respectively, corroborates GPR as a promising tool.

Introduction: Nowadays clinicians don't have a useful tumoral marker to perform the follow up of patients affected of head and neck cancers (H&NC). Objectives: To analyse the operative characteristics of prealbumin (PRB) as a tumoral activity marker in those affected of head and neck cancer compared with albumin, total proteins, carcinoembryonic antigen, and alfa fetoprotein. Methods: It was performed an observational prospective study with patients visited in Hospital Universitari Arnau de Vilanova de Lleida (Spain) with the main diagnosis of H&NC. During study time main epidemiological, clinical, and analytical (including PRB) characteristics were collected in 3 times: at diagnosis, after finishing the treatment and 12 months later. Results: Blood samples were obtained from 138 patients from the 1st January 2007 till the 1st February 2010. Median age was 62.5 (29-89) years and 121 (88%) were males. Most frequent histological diagnosis was scamous carcinoma 87 cases (63%). 19 patients (14.5) died during that time. Sensitivity, specificity, positive and negative predictive values of PRB were 63%, 100%, 100%, 87% respectively. The area under receiver operating characteristic curve was 0.87 (CI 0.76-0.98), that was better than other parameters studied. Conclusions: Prealbumin is a useful tumoral activity marker in those affected of head and neck cancer and it could be a useful tool in these patients follow up.

This paper presents a Partial-Power processing architecture implemented on a Battery Energy Storage System (BESS). This model allows for easy control of the battery charging current. The purpose has been to improve the overall efficiency of the system while reducing power losses with respect to the full-power converter. Now the converter only processes the differential power, which allows a reduction of the nominal power in the DC-DC converter, and therefore the power losses decrease. The topology used for the design of the partial-power converter has been an isolated Full-Bridge converter with synchronous rectifier. This architecture has some advantages over traditional topology such as high power density, small size, or low cost since the DC-DC converter only processes a fraction of the total power. The effectiveness of the strategy has been validated by the Matlab/Simulink software simulation.

Metal cyanides and isocyanides play a relevant role in the metal chemistry of the carbon-rich circumstellar envelope IRC+10216. It is thought that hydrometal cyanides/isocyanides could also be present in these environments; in fact, HMgNC has been detected in the same source that MgCN, MgNC, and AlNC. The aim of this work is to provide information about hydroaluminum cyanide/isocyanide. For this goal, a comprehensive analysis of the doublet and quartet potential energy surfaces of the [Al, C, H, N] system has been carried out. Different quantum chemistry methodologies from density functional theory to ab initio have been employed. For the [Al, C, H, N] isomers, the stability against dissociation and their interconversion processes have been analyzed. Our results show that the most relevant isomers from an experimental point of view are HAlCN and HAlNC. HAlNC has been found to be the most stable isomer followed by HAlCN, which is located at 1.59 kcal mol−1 (0.0689 eV) at the composite level. The interconversion process between HAlCN and HAlNC presents an energy barrier of 10.0 kcal mol−1 (5032 K) that makes this process not viable in the interstellar medium. We provide a complete set of relevant spectroscopic parameters for rotational spectroscopy for both HAlCN and HAlNC isomers using state-of-the-art quantum chemical computations, mandatory to guide an eventual laboratory or interstellar detection. Moreover, both isomers present sizable μ a dipole moment components (3.7 and 3.3 D, respectively), which are large enough to enable a characterization by means of rotational spectroscopy, further increasing their interest as interstellar candidates.

This positioning document, sponsored by the Asociacion Espanola de Gastroenterologia, the Sociedad Espanola de Endoscopia Digestiva and the Sociedad Espanola de Anatomia Patologica, aims to establish recommendations for the screening of gastric cancer (GC) in low incidence populations, such as the Spanish. To establish the quality of the evidence and the levels of recommendation, we used the methodology based on the GRADE system (Grading of Recommendations Assessment, Development and Evaluation). We obtained a consensus among experts using a Delphi method. The document evaluates screening in the general population, individuals with relatives with GC and subjects with GC precursor lesions (GCPL). The goal of the interventions should be to reduce GC related mortality. We recommend the use of the OLGIM classification and determine the intestinal metaplasia (IM) subtype in the evaluation of GCPL. We do not recommend to establish endoscopic mass screening for GC or Helicobacter pylori. However, the document strongly recommends to treat H.pylori if the infection is detected, and the investigation and treatment in individuals with a family history of GC or with GCPL. Instead, we recommend against the use of serological tests to detect GCPL. Endoscopic screening is suggested only in individuals that meet familial GC criteria. As for individuals with GCPL, endoscopic surveillance is only suggested in extensive IM associated with additional risk factors (incomplete IM and/or a family history of GC), after resection of dysplastic lesions or in patients with dysplasia without visible lesion after a high quality gastroscopy with chromoendoscopy.

Background Peru has a public health problem because of asbestos imports. We analyzed the mortality trends for mesothelioma in Peru and its provinces from 2005 to 2014 and estimated their relationship with the amount of asbestos imported previously. Methods We computed age-standardized mortality rates (ASMRs) per 100,000 population (direct method and SEGI world standard population reference), and the standardized mortality ratio (SMR). The relationship between the amount of asbestos imported annually along the period 1965–2010 and the number of mesothelioma deaths per year from 2005 to 2014 was estimated by log-linear Poisson regression models and Pearson correlation calculations. Results After correcting the number of deaths, Peru registered 428 cases (or 430 when corrected cases are rounded by sex) between 2005 and 2014. The highest ASMRs were in Arequipa and Callao (range: 0.40−0.41/100,000 population), followed by Huancavelica (0.36/100,000 population). This translates into approximately one death per each 68–111 of asbestos tons imported. The latency period for the higher level of positive correlation found was 8 years (r = 0.8). Male female sex ratio was lower in provinces such as Junin and Hunacavelica with geological asbestos risk. Conclusions Two patterns of mesothelioma risk have been detected, occupational and environmental. During the 2002–2006 years, Peru increased the asbestos use. If crocidolite imports were also increased, this could be behind the 8 years latency period detected. Peru should boost strategies towards the total ban of all forms of asbestos.

Background Despite progress in medical and skilled delivery care worldwide, neonatal and maternal mortality is still a major public health problem in resource-limited settings.Objective To determine whether psychosocial interventions (PSI) can reduce neonatal and maternal mortality in low-and middle-income countries, and which approaches are most promising.Methods Randomised controlled trials comparing a PSI with a control condition were identified through systematic searches in seven databases. Effects were pooled as risk ratios in random-effects meta-analyses. Risk of bias was assessed using the Cochrane risk of bias tool, and publication bias was estimated. Sensitivity analyses were conducted to investigate sources of heterogeneity.ResultsOf 22 eligible RCTs (20 cluster randomised trials), the outcomes of 21 were synthesized for the outcome of neonatal mortality and 14 for maternal mortality. PSIs effectively reduced the risk of neonatal mortality by about 15% (RR 0.85, 95% CI 0.78-0.94). The risk of maternal death was reduced by almost 21% (RR 0.79, 95% CI 0.68-0.93) with low levels of heterogeneity. There was low to medium risk of bias and no indication for substantial publication bias.Conclusions Results suggest that PSIs, mainly multi-method and group-based approaches, have the potential to substantially decrease the risk of maternal and neonatal death in low- and middle-income countries. The results of the latter outcome are marked by high heterogeneity and thus to be taken with caution.

Raman Laser Spectrometer (RLS) is the Pasteur Payload instrument of the ExoMars mission that will perform Raman spectroscopy for the first time in a planetary space mission. RLS main units are: SPU (SPectrometer Unit), iOH (internal Optical Head), and ICEU (Instrument Control and Excitation Unit), that includes the laser for samples excitation purposes. The iOH focuses the excitation laser into the crushed samples (located at the ALD, Analytical Laboratory Drawer, carrousel) through the excitation path, and collects the Raman emission from the sample (collection path). Its original design presented a high laser trace reaching to the SPU detector, and although a certain level was required for instrument calibration, the found level was expected to be capable of degrading the acquired spectra confounding some Raman peaks. So, the iOH optical and opto-mechanical designs were needed to be updated from the BB (Bread Board) to the engineering and qualification model (iOH EQM), in order to fix the desired amount of laser trace, and after the fabrication and the commitment of the commercial elements, the assembly and integration verification (AIV) process was carried out. Considering the results obtained during the EQM integration verification and the first functional tests, the RLS calibration target (CT) emission analysis, additional changes were found to be required for the Flight Model, FM. In this paper, the RLS iOH designs and functional tests evolutions for the different models are summarized, focusing on the iOH AIV process and emphasizing on the iOH performance evaluation (by using CT spectra) from the re-design activities., Ministerio de Economía y Competitividad. Grant Numbers: ESP2013‐48427‐C3‐3, ESP2014‐56138‐C3‐3‐R; With funding from the Spanish government through the "María de Maeztu Unit of Excellence" accreditation (MDM-2017-0737)

Producción Científica, We present a computational study of the different conformers of amino acetaldehyde. This molecule is a precursor of glycine and also an isomer of the detected molecules acetaldehyde and methylformamide. In addition, a previous theoretical result shows that amino acetaldehyde could be formed from the gas phase reaction of formamide with CH+5⁠. Different computational approaches, going from density functional theory (DFT) to coupled cluster (CC) calculations, are employed for the characterization of the amino acetaldehyde conformers. We locate four low-lying conformation on the singlet potential energy surface (PES), two with a synperiplanar arrangement of the carboxylic oxygen atom and the NH2 group, and the other two conformers with an anticlinal disposition. All levels of theory predict the conformer with a synperiplanar arrangement and the H atoms of the NH2 group pointing in the direction of the oxygen, denoted as in-sp-amino acetaldehyde, as the most stable. The viability of the interconversion processes between the four conformers in space is analysed. Relevant spectroscopic parameters to rotational spectroscopy with ‘spectroscopic’ accuracy at the composite level are reported. Vibrational frequencies and infrared intensities are also computed at the CC with single and double excitations (CCSD) level including anharmonic corrections. This information could help in the experimental characterization of amino acetaldehyde that could be considered as a good candidate molecule to be searched for in space., Ministerio de Economía, Industria y Competitividad (Grant AYA2017-87515-P), Junta de Castilla y León (Ref. project VA010G18)

Consumers are more disposed towards paying price premiums for sustainable food products. This fact is especially important for products with a PDO (Protected Designation of Origin) label, such as the high-acidity apple cultivar ‘Reinette du Canada’. However, ‘Reinette du Canada’ apple fruit is affected by two of the main post-harvest disorders in apple cultivars, bitter pit and senescent breakdown. As a means to achieve sustainable production of this high-quality apple cultivar, the effect of a sustainable preharvest technique, summer pruning, in combination with a zero-residue postharvest treatment allowed in organic farming on calcium-related disorders and quality in global terms in this PDO-labelled apple cultivar was assessed during storage. The combination of the two sustainable practices was an effective tool in diminishing senescent breakdown from 43% to 17% and to decrease bitter pit incidence by up to 21% (from 36% to 15%) throughout storage, especially in fruit with high susceptibility to this disorder during storage. Moreover, the overall acceptability was kept high (values of more than 3 on a 5-point scale) when applying this environment-friendly sustainable horticulture practice, which will not only reduce the synthetic pesticide input in the apple agroecosystem, but also contribute to producing fruit with zero residues.

Gastric carcinogenesis proceeds through a series of gastric cancer precursor lesions (GCPLs) leading to gastric cancer (GC) development. Although Helicobacter pylori infection initiates this process, genetic factors also play a role. We previously reported that genetic variability in MUC2 is associated with the evolution of GCPLs. In order to replicate previous results in an independent sample series and to explore whether genetic variability in other candidate genes plays a role in the evolution of GCPL, genomic DNA from 559 patients with GCPLs, recruited from 9 Spanish hospitals and followed for a mean of 12 years, was genotyped for 141 SNPs in 29 genes. After follow-up, 45.5% of the lesions remained stable, 37% regressed and 17.5% progressed to a more severe lesion. Genetic association with the evolution of the lesions (progression or regression) was analyzed by multinomial and binomial logistic regression. After correction for multiple comparisons, the results obtained confirmed the inverse association between MUC2 variants and the regression of the lesions. A significant association was also observed between NFKB1 and CD14 variants and the evolution of the lesions; interestingly, this association was with both progression and regression in the same direction, which could reflect the dual role of inflammation in cancer. Stratified analyses according to H. pylori virulence factors indicated some significant and differential effects but none of them passed the FDR test. These results confirm that genetic variability in MUC2, NFKB1 and CD14 may have a role in the evolution of the GCPLs along time and in gastric carcinogenesis.

Synthesis of materials with combined chemistry and textural properties of carbon and silica aerogels was studied. The synthesized support was modified with ruthenium using evaporation impregnation and deposition–precipitation methods. The ruthenium modification methods were observed to influence the particle size, dispersion, surface area, pore volume and acidity of Ru–C–SiO2 catalysts. Ruthenium particles of 1–2 nm were obtained with a simple impregnation–evaporation method, while deposition precipitations technique gave ruthenium particles ranging from 1 to 8 nm. Small Ru nanoparticles (1–2 nm) were stable even after being exposed at 700 °C or washed with ethanol for regeneration. Furthermore, the catalytic properties of Ru–C–SiO2 catalysts in sugar hydrogenation were also observed to be influenced by the synthesis methods. The catalysts were tested in hydrogenation of sugars with different molecule sizes (i.e. glucose and cellobiose). d-Glucose was more reactive than d-cellobiose when they were studied separately. For the mixture of sugars higher reactivity of both sugars was observed in comparison with neat substrates for the catalyst made by evaporation-impregnation. On the contrary no significant differences between kinetics of the separated sugars and their mixture were observed for the catalyst prepared by deposition–precipitation. The results can be attributed to acidity and a combination of meso and microporosity of the catalysts. The support composite material could also be produced as a monolith, being a promising candidate for future industrial applications.

III Jornades d’Investigació per a l’Alumnat de la Facultat de Ciències de la Salut Introducción: Las intervenciones auto-aplicadas a través de Internet cuentan con resultadosconsistentes respecto a su eficacia como tratamiento psicológico. Sin embargo,las altas tasas de abandono siguen suponiendo un reto. El apoyo recibido por partedel terapeuta a lo largo de la intervención es una de las variables que pueden influiren estas tasas (Karyotaki et al., 2017). Objetivo: Este estudio pretende analizar lasdiferencias en satisfacción, agrado y utilidad respecto a recibir o no apoyo telefónicoen una intervención auto-aplicada a través de Internet para la depresión. Método: 80participantes con síntomas depresivos fueron aleatorizados en dos condiciones experimentales:Intervención auto-aplicada con apoyo (N = 44) y sin apoyo telefónico (N =36). En el post-tratamiento se evaluó el grado de satisfacción con la intervención, asícomo el agrado y utilidad de las llamadas. Resultados: Ambos grupos valoraron, sindiferencias significativas entre ellos, que estaban satisfechos con el tratamiento. Únicamentese observaron diferencias significativas (F = 4,67; p = 0,035) en relación a laaversividad del mismo, valorándolo como más aversivo el grupo sin apoyo telefónico.El grupo que contaba con el contacto telefónico lo evaluó con un alto porcentaje deagrado y utilidad, mientras que el grupo sin apoyo no valoró tan positivamente la posibilidadde haber dispuesto de éste. Conclusiones: Los resultados obtenidos sugierenla importancia de ofrecer apoyo telefónico durante la intervención auto-aplicada, sinembargo, también plantean que, en los programas con los que el usuario se sientesatisfecho, el apoyo explícito se vuelve menos necesario. Introduction: Self-applied interventions via the Internet have shown consistent resultsregarding their efficacy as psychological treatment. However, they are characterized bya high dropout rate. This issue can be influenced by the support the therapist offersthroughout the intervention (Karyotaki et al., 2017). Objective: This study intends toanalyse whether «satisfaction», liking and «utility» indexes are different between patientsreceiving or not this telephone support during a self-applied intervention for depressionvia the Internet. Methods: 80 participants presenting depressive symptomswere randomized in two experimental conditions: Self-applied interventions via the Internetwith and without telephone support (N = 44 and N = 36, respectively). When thetreatment was finished, satisfaction with the intervention, and liking and utility degreeof these calls were evaluated. Results: No significant differences were observed betweengroups in terms of satisfaction, being both groups satisfied with the treatment.Significant differences were only found on treatment aversion (F = 4.67; p = 0.035),being considered more aversive by the group without telephone support. The group thatreceived telephone support assessed this human intervention with a high percentageof satisfaction and utility, while the group without this kind of support did not appreciatethe possibility of having this contact. Conclusions: Present results suggest the importanceof offering support during the self-applied intervention. However, they also pointout that in programs in which participants feel satisfied, explicit support becomes lessnecessary.