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52. European Society of Cardiology Quality Indicators for the care and outcomes of cardiac pacing: developed by the Working Group for Cardiac Pacing Quality Indicators in collaboration with the European Heart Rhythm Association of the European Society of Cardiology

Author

Aktaa, Suleman, primary, Abdin, Amr, additional, Arbelo, Elena, additional, Burri, Haran, additional, Vernooy, Kevin, additional, Blomström-Lundqvist, Carina, additional, Boriani, Giuseppe, additional, Defaye, Pascal, additional, Deharo, Jean-Claude, additional, Drossart, Inga, additional, Foldager, Dan, additional, Gold, Michael R, additional, Johansen, Jens Brock, additional, Leyva, Francisco, additional, Linde, Cecilia, additional, Michowitz, Yoav, additional, Kronborg, Mads Brix, additional, Slotwiner, David, additional, Steen, Torkel, additional, Tolosana, José Maria, additional, Tzeis, Stylianos, additional, Varma, Niraj, additional, Glikson, Michael, additional, Nielsen, Jens Cosedis, additional, and Gale, Chris P, additional

Published
2021
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53. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Glikson, Michael, primary, Nielsen, Jens Cosedis, additional, Kronborg, Mads Brix, additional, Michowitz, Yoav, additional, Auricchio, Angelo, additional, Barbash, Israel Moshe, additional, Barrabés, José A., additional, Boriani, Giuseppe, additional, Braunschweig, Frieder, additional, Brignole, Michele, additional, Burri, Haran, additional, Coats, Andrew J. S., additional, Deharo, Jean-Claude, additional, Delgado, Victoria, additional, Diller, Gerhard-Paul, additional, Israel, Carsten W., additional, Keren, Andre, additional, Knops, Reinoud E., additional, Kotecha, Dipak, additional, Leclercq, Christophe, additional, Merkely, Béla, additional, Starck, Christoph, additional, Thylén, Ingela, additional, Tolosana, José Maria, additional, Leyva, Francisco, additional, Linde, Cecilia, additional, Abdelhamid, Magdy, additional, Aboyans, Victor, additional, Arbelo, Elena, additional, Asteggiano, Riccardo, additional, Barón-Esquivias, Gonzalo, additional, Bauersachs, Johann, additional, Biffi, Mauro, additional, Birgersdotter-Green, Ulrika, additional, Bongiorni, Maria Grazia, additional, Borger, Michael A., additional, Čelutkienė, Jelena, additional, Cikes, Maja, additional, Daubert, Jean-Claude, additional, Drossart, Inga, additional, Ellenbogen, Kenneth, additional, Elliott, Perry M., additional, Fabritz, Larissa, additional, Falk, Volkmar, additional, Fauchier, Laurent, additional, Fernández-Avilés, Francisco, additional, Foldager, Dan, additional, Gadler, Fredrik, additional, De Vinuesa, Pastora Gallego Garcia, additional, Gorenek, Bulent, additional, Guerra, Jose M., additional, Hermann Haugaa, Kristina, additional, Hendriks, Jeroen, additional, Kahan, Thomas, additional, Katus, Hugo A., additional, Konradi, Aleksandra, additional, Koskinas, Konstantinos C., additional, Law, Hannah, additional, Lewis, Basil S., additional, Linker, Nicholas John, additional, Løchen, Maja-Lisa, additional, Lumens, Joost, additional, Mascherbauer, Julia, additional, Mullens, Wilfried, additional, Nagy, Klaudia Vivien, additional, Prescott, Eva, additional, Raatikainen, Pekka, additional, Rakisheva, Amina, additional, Reichlin, Tobias, additional, Ricci, Renato Pietro, additional, Shlyakhto, Evgeny, additional, Sitges, Marta, additional, Sousa-Uva, Miguel, additional, Sutton, Richard, additional, Suwalski, Piotr, additional, Svendsen, Jesper Hastrup, additional, Touyz, Rhian M., additional, Van Gelder, Isabelle C., additional, Vernooy, Kevin, additional, Waltenberger, Johannes, additional, Whinnett, Zachary, additional, and Witte, Klaus K., additional

Published
2021
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56. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)

Author

Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabes, Jose A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, Maria Tolosana, Jose, Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabes, Jose A., Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J. S., Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W., Keren, Andre, Knops, Reinoud E., Kotecha, Dipak, Leclercq, Christophe, Merkely, Bela, Starck, Christoph, Thylén, Ingela, and Maria Tolosana, Jose

Abstract

n/a

Published
2021
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60. Cardiac arrhythmias amongst hospitalised Coronavirus 2019 (COVID‐19) patients: Prevalence, characterisation, and clinical algorithm to classify arrhythmic risk

Author

Rav‐Acha, Moshe, primary, Orlev, Amir, additional, Itzhaki, Itay, additional, Zimmerman, Shmuel F., additional, Fteiha, Bashar, additional, Bohm, Davina, additional, Kurd, Ramzi, additional, Samuel, Tal Y., additional, Asher, Elad, additional, Helviz, Yigal, additional, Glikson, Michael, additional, and Michowitz, Yoav, additional

Published
2021
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61. Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms:results from a multicentre long-term registry

Author

Conte, Giulio, Belhassen, Bernard, Lambiase, Pier, Ciconte, Giuseppe, de Asmundis, Carlo, Arbelo, Elena, Schaer, Beat, Frontera, Antonio, Burri, Haran, Calo', Leonardo, Letsas, Kostantinos P., Leyva, Francisco, Porter, Bradley, Saenen, Johan, Zacà, Valerio, Berne, Paola, Ammann, Peter, Zardini, Marco, Luani, Blerim, Rordorf, Roberto, Sarquella Brugada, Georgia, Medeiros-Domingo, Argelia, Geller, Johann Christoph, de Potter, Tom, Stokke, Mathis K., Márquez, Manlio F., Michowitz, Yoav, Honarbakhsh, Shohreh, Conti, Manuel, Sticherling, Christian, Martino, Annamaria, Zegard, Abbasin, Özkartal, Tardu, Caputo, Maria Luce, Regoli, François, Braun-Dullaeus, Rüdiger C., Notarangelo, Francesca, Moccetti, Tiziano, Casu, Gavino, Rinaldi, Christopher A., Levinstein, Moises, Haugaa, Kristina H., Derval, Nicolas, Klersy, Catherine, Curti, Moreno, Pappone, Carlo, Heidbuchel, Hein, Brugada, Josép, Haïssaguerre, Michel, Brugada, Pedro, and Auricchio, Angelo

Abstract

AIMS : To define the clinical characteristics and long-term clinical outcomes of a large cohort of patients with idiopathic ventricular fibrillation (IVF) and normal 12-lead electrocardiograms (ECGs). METHODS AND RESULTS: Patients with ventricular fibrillation as the presenting rhythm, normal baseline, and follow-up ECGs with no signs of cardiac channelopathy including early repolarization or atrioventricular conduction abnormalities, and without structural heart disease were included in a registry. A total of 245 patients (median age: 38 years; males 59%) were recruited from 25 centres. An implantable cardioverter-defibrillator (ICD) was implanted in 226 patients (92%), while 18 patients (8%) were treated with drug therapy only. Over a median follow-up of 63 months (interquartile range: 25-110 months), 12 patients died (5%); in four of them (1.6%) the lethal event was of cardiac origin. Patients treated with antiarrhythmic drugs only had a higher rate of cardiovascular death compared to patients who received an ICD (16% vs. 0.4%, P = 0.001). Fifty-two patients (21%) experienced an arrhythmic recurrence. Age ≤16 years at the time of the first ventricular arrhythmia was the only predictor of arrhythmic recurrence on multivariable analysis [hazard ratio (HR) 0.41, 95% confidence interval (CI) 0.18-0.92; P = 0.03]. CONCLUSION : Patients with IVF and persistently normal ECGs frequently have arrhythmic recurrences, but a good prognosis when treated with an ICD. Children are a category of IVF patients at higher risk of arrhythmic recurrences.

Published
2019

62. Prior peripheral arterial disease and cerebrovascular disease are independent predictors of adverse outcome in patients with acute coronary syndromes: Are we doing enough? Results from the Orbofiban in patients with unstable coronary syndromes-Trombolysis in myocardial infarction (OPUS-TIMI) 16 study

Author

Cotter, Gad, Cannon, Christopher P., McCabe, Carolyn H., Michowitz, Yoav, Kaluski, Edo, Charlesworth, Andrew, Milo, Olga, Bentley, Jane, Blatt, Alex, Krakover, Rikardo, Zimlichman, Reuven, Reisin, Leonardo, Marmor, Alon, Lewis, Basil, Vered, Zvi, Caspi, Avi, and Braunwald, Eugene

Subjects
Heart attack -- Analysis, Cerebrovascular disease -- Research, Peripheral vascular diseases -- Research, Health
Published
2003

69. Cardiac arrhythmias among hospitalized Coronavirus 2019 (COVID-19) patients: prevalence, characterization, and clinical algorithm to classify arrhythmic risk

Author

Acha, Moshe Rav, primary, Orlev, Amir, additional, Itzhaki, Itay, additional, Zimmerman, Shmuel F, additional, Fteiha, Bashar, additional, Bohm, Davina, additional, Kurd, Ramzi, additional, Samuel, Tal Y, additional, Asher, Elad, additional, Helviz, Yigal, additional, Glikson, Michael, additional, and Michowitz, Yoav, additional

Published
2020
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76. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de cardiologie pédiatrique, Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez, Maria Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J M, Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G, Hochstadt, Aviram, Wijeyeratne, Yanushi D, Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F, Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R, Wilde, Arthur A M, Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, Belhassen, Bernard, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de cardiologie pédiatrique, Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez, Maria Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J M, Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G, Hochstadt, Aviram, Wijeyeratne, Yanushi D, Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F, Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R, Wilde, Arthur A M, Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, and Belhassen, Bernard

Abstract

BACKGROUND: Information on young patients with Brugada syndrome (BrS) and arrhythmic events (AEs) is limited. OBJECTIVES: The purpose of this study was to describe their characteristics and management as well as risk factors for AE recurrence. METHODS: A total of 57 patients (age ≤20 years), all with BrS and AEs, were divided into pediatric (age ≤12 years; n = 26) and adolescents (age 13 to 20 years; n = 31). RESULTS: Patients' median age at time of first AE was 14 years, with a majority of males (74%), Caucasians (70%), and probands (79%) who presented as aborted cardiac arrest (84%). A significant proportion of patients (28%) exhibited fever-related AE. Family history of sudden cardiac death (SCD), prior syncope, spontaneous type 1 Brugada electrocardiogram (ECG), inducible ventricular fibrillation at electrophysiological study, and SCN5A mutations were present in 26%, 49%, 65%, 28%, and 58% of patients, respectively. The pediatric group differed from the adolescents, with a greater proportion of females, Caucasians, fever-related AEs, and spontaneous type-1 ECG. During follow-up, 68% of pediatric and 64% of adolescents had recurrent AE, with median time of 9.9 and 27.0 months, respectively. Approximately one-third of recurrent AEs occurred on quinidine therapy, and among the pediatric group, 60% of recurrent AEs were fever-related. Risk factors for recurrent AE included sinus node dysfunction, atrial arrhythmias, intraventricular conduction delay, or large S-wave on ECG lead I in the pediatric group and the presence of SCN5A mutation among adolescents. CONCLUSIONS: Young BrS patients with AE represent a very arrhythmogenic group. Current management after first arrhythmia episode is associated with high recurrence rate. Alternative therapies, besides defibrillator implantation, should be considered.

Published
2019

77. Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator:data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, Hochstadt, Aviram, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Conte, Giulio, Arbelo, Elena, Kamakura, Tsukasa, Aiba, Takeshi, Napolitano, Carlo, Giustetto, Carla, Denjoy, Isabelle, Juang, Jimmy J M, Maeda, Shingo, Takahashi, Yoshihide, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Jespersen, Camilla H, Wijeyeratne, Yanushi D, Champagne, Jean, Calo, Leonardo, Huang, Zhengrong, Mizusawa, Yuka, Postema, Pieter G, Brugada, Ramon, Wilde, Arthur A M, Yan, Gan-Xin, Behr, Elijah R, Tfelt-Hansen, Jacob, Hirao, Kenzo, Veltmann, Christian, Leenhardt, Antoine, Corrado, Domenico, Gaita, Fiorenzo, Priori, Silvia G, Kusano, Kengo F, Takagi, Masahiko, Delise, Pietro, Brugada, Josep, Brugada, Pedro, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Hochstadt, Aviram, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Conte, Giulio, Arbelo, Elena, Kamakura, Tsukasa, Aiba, Takeshi, Napolitano, Carlo, Giustetto, Carla, Denjoy, Isabelle, Juang, Jimmy J M, Maeda, Shingo, Takahashi, Yoshihide, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Jespersen, Camilla H, Wijeyeratne, Yanushi D, Champagne, Jean, Calo, Leonardo, Huang, Zhengrong, Mizusawa, Yuka, Postema, Pieter G, Brugada, Ramon, Wilde, Arthur A M, Yan, Gan-Xin, Behr, Elijah R, Tfelt-Hansen, Jacob, Hirao, Kenzo, Veltmann, Christian, Leenhardt, Antoine, Corrado, Domenico, Gaita, Fiorenzo, Priori, Silvia G, Kusano, Kengo F, Takagi, Masahiko, Delise, Pietro, Brugada, Josep, Brugada, Pedro, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Aims: Data on predictors of time-to-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce.Methods and results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-to-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-to-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-to-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built.Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy.

Published
2019

78. Ethnic differences in patients with Brugada syndrome and arrhythmic events:New insights from Survey on Arrhythmic Events in Brugada Syndrome

Author

Milman, Anat, Andorin, Antoine, Postema, Pieter G., Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Michowitz, Yoav, Fogelman, Rami, Hochstadt, Aviram, Mizusawa, Yuka, Giustetto, Carla, Arbelo, Elena, Huang, Zhengrong, Corrado, Domenico, Delise, Pietro, Allocca, Giuseppe, Takagi, Masahiko, Wijeyeratne, Yanushi D., Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Jespersen, Camilla H., Tfelt-Hansen, Jacob, Veltmann, Christian, Priori, Silvia G., Behr, Elijah R., Yan, Gan Xin, Brugada, Josep, Gaita, Fiorenzo, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Andorin, Antoine, Postema, Pieter G., Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Michowitz, Yoav, Fogelman, Rami, Hochstadt, Aviram, Mizusawa, Yuka, Giustetto, Carla, Arbelo, Elena, Huang, Zhengrong, Corrado, Domenico, Delise, Pietro, Allocca, Giuseppe, Takagi, Masahiko, Wijeyeratne, Yanushi D., Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Jespersen, Camilla H., Tfelt-Hansen, Jacob, Veltmann, Christian, Priori, Silvia G., Behr, Elijah R., Yan, Gan Xin, Brugada, Josep, Gaita, Fiorenzo, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Background: There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs). Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS and AEs. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter survey from Western and Asian countries, gathering 678 patients with BrS and first documented AE. After excluding patients with other (n = 14 [2.1%]) or unknown (n = 30 [4.4%]) ethnicity, 364 (53.7%) whites and 270 (39.8%) Asians comprised the study group. Results: There was no difference in AE age onset (41.3 ± 16.1 years in whites vs 43.3 ± 12.3 years in Asians; P = .285). Higher proportions of whites were observed in pediatric and elderly populations. Asians were predominantly men (98.1% vs 85.7% in whites; P < .001) and frequently presented with aborted cardiac arrest (71.1% vs 56%; P < .001). Asians tended to display more spontaneous type 1 BrS-ECG pattern (71.5% vs 64.3%; P = .068). A family history of sudden cardiac death was noted more in whites (29.1% vs 11.5%; P < .001), with a higher rate of SCN5A mutation carriers (40.1% vs 13.2% in Asians; P < .001), as well as more fever-related AEs (8.5% vs 2.9%; P = .011). No difference was observed between the 2 groups regarding history of syncope and ventricular arrhythmia inducibility. Conclusion: There are important differences between Asian and white patients with BrS. Asian patients present almost exclusively as male adults, more often with aborted cardiac arrest and spontaneous type 1 BrS-ECG. However, they have less family history of sudden cardiac death and markedly lower SCN5A mutation rates. The striking difference in SCN5A mutation rates should be tested in future studies.

Published
2019

79. Profile of Brugada Syndrome Patients Presenting with Their First Documented Arrhythmic Event. Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, Andorin, Antoine, Gourraud, Jean-Baptiste, Postema, Pieter G, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Juang, Jimmy Jm, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Sarquella-Brugada, Georgia, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A. M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Other departments, and ACS - Heart failure & arrhythmias

Subjects
arrhythmic risk stratification, ICD, electrophysiologic study, genetics, sudden cardiac death
Abstract

BACKGROUND: Detailed information on the profile of Brugada syndrome (BrS) patients presenting their first arrhythmic event (AE) after prophylactic implantation of a cardioverter defibrillator (ICD) is limited. OBJECTIVES: 1) To compare clinical, electrocardiographic, electrophysiologic and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (CA) (group A) with those in whom the AE was documented after prophylactic ICD implantation (group B); 2) To characterize group B patients' profile using the Class II indications for ICD implantation established by HRS/EHRA/APHRS Expert Consensus Statement in 2013. METHODS: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 BrS patients with AE (group A, n=426; group B, n=252). RESULTS: First AE occurred in group B patients 6.7 years later than in group A (46.1+ 13.3 vs. 39.4+15.1, P

Published
2018

80. Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry

Author

Conte, Giulio, primary, Belhassen, Bernard, additional, Lambiase, Pier, additional, Ciconte, Giuseppe, additional, de Asmundis, Carlo, additional, Arbelo, Elena, additional, Schaer, Beat, additional, Frontera, Antonio, additional, Burri, Haran, additional, Calo’, Leonardo, additional, Letsas, Kostantinos P, additional, Leyva, Francisco, additional, Porter, Bradley, additional, Saenen, Johan, additional, Zacà, Valerio, additional, Berne, Paola, additional, Ammann, Peter, additional, Zardini, Marco, additional, Luani, Blerim, additional, Rordorf, Roberto, additional, Sarquella Brugada, Georgia, additional, Medeiros-Domingo, Argelia, additional, Geller, Johann-Christoph, additional, de Potter, Tom, additional, Stokke, Mathis K, additional, Márquez, Manlio F, additional, Michowitz, Yoav, additional, Honarbakhsh, Shohreh, additional, Conti, Manuel, additional, Sticherling, Christian, additional, Martino, Annamaria, additional, Zegard, Abbasin, additional, Özkartal, Tardu, additional, Caputo, Maria Luce, additional, Regoli, François, additional, Braun-Dullaeus, Rüdiger C, additional, Notarangelo, Francesca, additional, Moccetti, Tiziano, additional, Casu, Gavino, additional, Rinaldi, Christopher A, additional, Levinstein, Moises, additional, Haugaa, Kristina H, additional, Derval, Nicolas, additional, Klersy, Catherine, additional, Curti, Moreno, additional, Pappone, Carlo, additional, Heidbuchel, Hein, additional, Brugada, Josép, additional, Haïssaguerre, Michel, additional, Brugada, Pedro, additional, and Auricchio, Angelo, additional

Published
2019
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81. Idiopathic Ventricular Fibrillation and Otherwise Normal Electrocardiograms

Author

Conte, Giulio, primary, Belhassen, Bernard, additional, Lambiase, Pier, additional, Ciconte, Giuseppe, additional, de Asmundis, Carlo, additional, Arbelo, Elena, additional, Schaer, Beat, additional, Frontera, Antonio, additional, Burri, Haran, additional, Calo, Leonardo, additional, Letsas, Kostantinos P., additional, Leyva, Francisco, additional, Porter, Bradley, additional, Saenen, Johan, additional, Zacà, Valerio, additional, Berne, Paola, additional, Ammann, Peter, additional, Zardini, Marco, additional, Luani, Blerim, additional, Rordorf, Roberto, additional, Sarquella Brugada, Georgia, additional, Medeiros-Domingo, Argelia, additional, Geller, Johann-Christoph, additional, de Potter, Tom, additional, Stokke, Mathis K., additional, Márquez, Manlio F., additional, Michowitz, Yoav, additional, Honarbakhsh, Shohreh, additional, Conti, Manuel, additional, Sticherling, Christian, additional, Martino, Annamaria, additional, Zegard, Abbasin, additional, Özkartal, Tardu, additional, Luce Caputo, Maria, additional, Regoli, François, additional, Braun-Dullaeus, Rüdiger C., additional, Notarangelo, Francesca, additional, Moccetti, Tiziano, additional, Casu, Gavino, additional, Rinaldi, Christopher A, additional, Levinstein, Moises, additional, Haugaa, Kristina H., additional, Derval, Nicolas, additional, Klersy, Catherine, additional, Curti, Moreno, additional, Pappone, Carlo, additional, Heidbuchel, Hein, additional, Brugada, Josép, additional, Haïssaguerre, Michel, additional, Brugada, Pedro, additional, and Auricchio, Angelo, additional

Published
2019
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82. Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, primary, Hochstadt, Aviram, additional, Andorin, Antoine, additional, Gourraud, Jean-Baptiste, additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Kim, Sung-Hwan, additional, Conte, Giulio, additional, Arbelo, Elena, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Napolitano, Carlo, additional, Giustetto, Carla, additional, Denjoy, Isabelle, additional, Juang, Jimmy J M, additional, Maeda, Shingo, additional, Takahashi, Yoshihide, additional, Leshem, Eran, additional, Michowitz, Yoav, additional, Rahkovich, Michael, additional, Jespersen, Camilla H, additional, Wijeyeratne, Yanushi D, additional, Champagne, Jean, additional, Calo, Leonardo, additional, Huang, Zhengrong, additional, Mizusawa, Yuka, additional, Postema, Pieter G, additional, Brugada, Ramon, additional, Wilde, Arthur A M, additional, Yan, Gan-Xin, additional, Behr, Elijah R, additional, Tfelt-Hansen, Jacob, additional, Hirao, Kenzo, additional, Veltmann, Christian, additional, Leenhardt, Antoine, additional, Corrado, Domenico, additional, Gaita, Fiorenzo, additional, Priori, Silvia G, additional, Kusano, Kengo F, additional, Takagi, Masahiko, additional, Delise, Pietro, additional, Brugada, Josep, additional, Brugada, Pedro, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2018
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83. Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event:Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, Andorin, Antoine, Gourraud, Jean Baptiste, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Sarquella-Brugada, Georgia, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D., Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Andorin, Antoine, Gourraud, Jean Baptiste, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Sarquella-Brugada, Georgia, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D., Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

BACKGROUND: Detailed information on the profile of patients with Brugada syndrome (BrS) presenting their first arrhythmic event (AE) after prophylactic implantation of an implantable cardioverter-defibrillator (ICD) is limited.OBJECTIVES: The objectives of this study were (1) to compare clinical, electrocardiographic, electrophysiologic, and genetic profiles of patients who exhibited their first documented AE as aborted cardiac arrest (group A) with profiles of those in whom the AE was documented after prophylactic ICD implantation (group B) and (2) to characterize group B patients' profile using the class II indications for ICD implantation established by HRS/EHRA/APHRS expert consensus statement in 2013.METHODS: A survey of 23 centers from 10 Western and 4 Asian countries enabled data collection of 678 patients with BrS who exhibited their AE (group A, n = 426; group B, n = 252).RESULTS: The first AE occurred in group B patients 6.7 years later than in group A (mean age 46.1 ± 13.3 years vs 39.4 ± 15.1 years; P < .001). Group B patients had a higher incidence of family history of sudden cardiac death and SCN5A mutations. Of the 252 group B patients, 189 (75%) complied with the HRS/EHRA/APHRS indications whereas the remaining 63 (25%) did not.CONCLUSION: Patients with BrS with the first AE documented after prophylactic ICD implantation exhibited their AE at a later age with a higher incidence of positive family history of sudden cardiac death and SCN5A mutations as compared with those presenting with aborted cardiac arrest. Only 75% of patients who exhibited an AE after receiving a prophylactic ICD complied with the 2013 class II indications, suggesting that efforts are still required for improving risk stratification.

Published
2018

84. Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Author

Michowitz, Yoav, Milman, Anat, Sarquella-Brugada, Georgia, Andorin, Antoine, Champagne, Jean, Postema, Pieter G., Casado-Arroyo, Ruben, Leshem, Eran, Juang, Jimmy J.M., Giustetto, Carla, Tfelt-Hansen, Jacob, Wijeyeratne, Yanushi D., Veltmann, Christian, Corrado, Domenico, Kim, Sung Hwan, Delise, Pietro, Maeda, Shingo, Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Hochstadt, Aviram, Mizusawa, Yuka, Rahkovich, Michael, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Napolitano, Carlo, Brugada, Ramon, Calo, Leonardo, Priori, Silvia G., Takagi, Masahiko, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Michowitz, Yoav, Milman, Anat, Sarquella-Brugada, Georgia, Andorin, Antoine, Champagne, Jean, Postema, Pieter G., Casado-Arroyo, Ruben, Leshem, Eran, Juang, Jimmy J.M., Giustetto, Carla, Tfelt-Hansen, Jacob, Wijeyeratne, Yanushi D., Veltmann, Christian, Corrado, Domenico, Kim, Sung Hwan, Delise, Pietro, Maeda, Shingo, Gourraud, Jean Baptiste, Sacher, Frederic, Mabo, Philippe, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Hochstadt, Aviram, Mizusawa, Yuka, Rahkovich, Michael, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Napolitano, Carlo, Brugada, Ramon, Calo, Leonardo, Priori, Silvia G., Takagi, Masahiko, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Background: The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. Objective: The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. Methods: The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). Results: In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. Conclusion: The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.

Published
2018

85. Gender differences in patients with Brugada syndrome and arrhythmic events:Data from a survey on arrhythmic events in 678 patients

Author

Milman, Anat, Gourraud, Jean Baptiste, Andorin, Antoine, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Conte, Giulio, Giustetto, Carla, Sarquella-Brugada, Georgia, Hochstadt, Aviram, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Wijeyeratne, Yanushi D., Napolitano, Carlo, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Gourraud, Jean Baptiste, Andorin, Antoine, Postema, Pieter G., Sacher, Frederic, Mabo, Philippe, Conte, Giulio, Giustetto, Carla, Sarquella-Brugada, Georgia, Hochstadt, Aviram, Kim, Sung Hwan, Juang, Jimmy J.M., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Leshem, Eran, Michowitz, Yoav, Rahkovich, Michael, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Wijeyeratne, Yanushi D., Napolitano, Carlo, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

Background: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). Objective: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. Methods: The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27–84 years (mean age 42.5 ± 14.1 years) at the time of AE occurrence. Results: After excluding pediatric patients, it was found that females were older than males (49.5 ± 14.4 years vs 43 ± 12.7 years, respectively; P =.001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was ≈9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (≈65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P <.001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P <.001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P =.007). Conclusion: This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than do males. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity.

Published
2018

87. Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients

Author

Milman, Anat, primary, Gourraud, Jean-Baptiste, additional, Andorin, Antoine, additional, Postema, Pieter G., additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Conte, Giulio, additional, Giustetto, Carla, additional, Sarquella-Brugada, Georgia, additional, Hochstadt, Aviram, additional, Kim, Sung-Hwan, additional, Juang, Jimmy J.M., additional, Maeda, Shingo, additional, Takahashi, Yoshihide, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Leshem, Eran, additional, Michowitz, Yoav, additional, Rahkovich, Michael, additional, Mizusawa, Yuka, additional, Arbelo, Elena, additional, Huang, Zhengrong, additional, Denjoy, Isabelle, additional, Wijeyeratne, Yanushi D., additional, Napolitano, Carlo, additional, Brugada, Ramon, additional, Casado-Arroyo, Ruben, additional, Champagne, Jean, additional, Calo, Leonardo, additional, Tfelt-Hansen, Jacob, additional, Priori, Silvia G., additional, Takagi, Masahiko, additional, Veltmann, Christian, additional, Delise, Pietro, additional, Corrado, Domenico, additional, Behr, Elijah R., additional, Gaita, Fiorenzo, additional, Yan, Gan-Xin, additional, Brugada, Josep, additional, Leenhardt, Antoine, additional, Wilde, Arthur A.M., additional, Brugada, Pedro, additional, Kusano, Kengo F., additional, Hirao, Kenzo, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2018
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89. Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Author

Michowitz, Yoav, primary, Milman, Anat, additional, Sarquella-Brugada, Georgia, additional, Andorin, Antoine, additional, Champagne, Jean, additional, Postema, Pieter G., additional, Casado-Arroyo, Ruben, additional, Leshem, Eran, additional, Juang, Jimmy J.M., additional, Giustetto, Carla, additional, Tfelt-Hansen, Jacob, additional, Wijeyeratne, Yanushi D., additional, Veltmann, Christian, additional, Corrado, Domenico, additional, Kim, Sung-Hwan, additional, Delise, Pietro, additional, Maeda, Shingo, additional, Gourraud, Jean-Baptiste, additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Takahashi, Yoshihide, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Conte, Giulio, additional, Hochstadt, Aviram, additional, Mizusawa, Yuka, additional, Rahkovich, Michael, additional, Arbelo, Elena, additional, Huang, Zhengrong, additional, Denjoy, Isabelle, additional, Napolitano, Carlo, additional, Brugada, Ramon, additional, Calo, Leonardo, additional, Priori, Silvia G., additional, Takagi, Masahiko, additional, Behr, Elijah R., additional, Gaita, Fiorenzo, additional, Yan, Gan-Xin, additional, Brugada, Josep, additional, Leenhardt, Antoine, additional, Wilde, Arthur A.M., additional, Brugada, Pedro, additional, Kusano, Kengo F., additional, Hirao, Kenzo, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2018
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90. Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: Data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS)

Author

Milman, Anat, primary, Andorin, Antoine, additional, Gourraud, Jean-Baptiste, additional, Postema, Pieter G., additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Kim, Sung-Hwan, additional, Juang, Jimmy J.M., additional, Maeda, Shingo, additional, Takahashi, Yoshihide, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Conte, Giulio, additional, Sarquella-Brugada, Georgia, additional, Leshem, Eran, additional, Rahkovich, Michael, additional, Hochstadt, Aviram, additional, Mizusawa, Yuka, additional, Arbelo, Elena, additional, Huang, Zhengrong, additional, Denjoy, Isabelle, additional, Giustetto, Carla, additional, Wijeyeratne, Yanushi D., additional, Napolitano, Carlo, additional, Michowitz, Yoav, additional, Brugada, Ramon, additional, Casado-Arroyo, Ruben, additional, Champagne, Jean, additional, Calo, Leonardo, additional, Tfelt-Hansen, Jacob, additional, Priori, Silvia G., additional, Takagi, Masahiko, additional, Veltmann, Christian, additional, Delise, Pietro, additional, Corrado, Domenico, additional, Behr, Elijah R., additional, Gaita, Fiorenzo, additional, Yan, Gan-Xin, additional, Brugada, Josep, additional, Leenhardt, Antoine, additional, Wilde, Arthur A.M., additional, Brugada, Pedro, additional, Kusano, Kengo F., additional, Hirao, Kenzo, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2018
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92. Age of First Arrhythmic Event in Brugada Syndrome:Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

Author

Milman, Anat, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J M, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Postema, Pieter G, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J M, Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Postema, Pieter G, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE.METHODS AND RESULTS: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years).CONCLUSIONS: SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

Published
2017

98. Time-to-first appropriate shock in patients implanted prophylactically with an implantable cardioverter-defibrillator: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS).

Author

Milman, Anat, Hochstadt, Aviram, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Conte, Giulio, Arbelo, Elena, Kamakura, Tsukasa, Aiba, Takeshi, Napolitano, Carlo, Giustetto, Carla, Denjoy, Isabelle, Juang, Jimmy J M, Maeda, Shingo, Takahashi, Yoshihide, Leshem, Eran, Michowitz, Yoav, and Rahkovich, Michael

Abstract

Aims: Data on predictors of time-to-first appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with Brugada Syndrome (BrS) and prophylactically implanted ICD's are scarce.Methods and Results: SABRUS (Survey on Arrhythmic Events in BRUgada Syndrome) is an international survey on 678 BrS patients who experienced arrhythmic event (AE) including 252 patients in whom AE occurred after prophylactic ICD implantation. Analysis was performed on time-to-first appropriate ICD discharge regarding patients' characteristics. Multivariate logistic regression models were utilized to identify which parameters predicted time to arrhythmia ≤5 years. The median time-to-first appropriate ICD therapy was 24.8 ± 2.8 months. A shorter time was observed in patients from Asian ethnicity (P < 0.05), those with syncope (P = 0.001), and those with Class IIa indication for ICD (P = 0.001). A longer time was associated with a positive family history of sudden cardiac death (P < 0.05). Multivariate Cox regression revealed shorter time-to-ICD therapy in patients with syncope [odds ratio (OR) 1.65, P = 0.001]. In 193 patients (76.6%), therapy was delivered during the first 5 years. Factors associated with this time were syncope (OR 0.36, P = 0.001), spontaneous Type 1 Brugada electrocardiogram (ECG) (OR 0.5, P < 0.05), and Class IIa indication (OR 0.38, P < 0.01) as opposed to Class IIb (OR 2.41, P < 0.01). A near-significant trend for female gender was also noted (OR 0.13, P = 0.052). Two score models for prediction of <5 years to shock were built.Conclusion: First appropriate therapy in BrS patients with prophylactic ICD's occurred during the first 5 years in 76.6% of patients. Syncope and spontaneous Type 1 Brugada ECG correlated with a shorter time to ICD therapy. [ABSTRACT FROM AUTHOR]

Published
2019
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99. Effects of Gender on the Incidence of Cardiac Tamponade Following Catheter Ablation of Atrial Fibrillation: Results from a Worldwide Survey in 34,943 AF Ablation Procedures

Author

Michowitz, Yoav, Rahkovich, Michael, Oral, Hakan, Zado, Erica S., Tilz, Roland, John, Silke, Denis, Arnaud, Di Biase, Luigi, Winkle, Roger A., Mikhaylov, Evgeny N., Ruskin, Jeremy N., Yao, Yan, Josephson, Mark E., Tanner, Hildegard, Miller, John M., Champagne, Jean, Della Bella, Paolo, Kumagai, Koichiro, Defaye, Pascal, Luria, David, Lebedev, Dmitry S., Natale, Andrea, Jaïs, Pierre, Hindricks, Gerhard, Kuck, Karl-Heinz, Marchlinski, Francis E., Morady, Fred, and Belhassen, Bernard

Subjects
610 Medicine & health
Abstract

BACKGROUND -Cardiac tamponade is the most dramatic complication observed during atrial fibrillation (AF) ablation and the leading cause of procedure-related mortality. Female gender is a known risk factor for complications during AF ablation; however, it is unknown whether women have a higher risk of tamponade. METHODS AND RESULTS -A systematic Medline search was used to locate academic electrophysiologic (EP) centers that reported cases of tamponade occurring during AF ablation. Centers were asked to provide information on cases of acute tamponade according to gender and their mode of management including any case of related mortality. Nineteen EP centers provided information on 34,943 ablation procedures involving 25,261 (72%) males. Overall 289 (0.9%) cases of tamponade were reported: 120 (1.24%) in females and 169 (0.67%) in males (odds ratio 1.83, P

Published
2014
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