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Your search keyword '"Meylan M"' showing total 476 results
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476 results on '"Meylan M"'

55. Kidney ccRCC immune classification (KIC) enhances the predictive value of T effector (Teff) and angiogenesis (Angio) signatures in response to nivolumab (N)

Author

Meylan, M., Beuselinck, B, Dalban, C., Vano, Y., Leclercq, N. Rioux, Sautès-Fridman, C., Roussel, E., Verbiest, A, Chaput, N., Terry, S., Chevreau, C., Gross-Goupil, M., Flechon, A, Laguerre, B., Chabaud, S., Tantot, F., Lambrechts, D., Escudier, B., Fridman, W.-H., Albiges, L., Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), University Hospitals Leuven [Leuven], Centre Léon Bérard [Lyon], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Institut Gustave Roussy (IGR), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, Institut Claudius Regaud, CHU Bordeaux [Bordeaux], Centre Eugène Marquis (CRLCC), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), UNICANCER, Leuven Center for Cancer Biology (VIB-KU-CCB), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Vlaams Instituut voor Biotechnologie [Ghent, Belgique] (VIB), Institut National du CancerInstitut National du Cancer (INCA) France, Bristol-Myers SquibbBristol-Myers Squibb, École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

57. 5-hydroxytryptamine-4 receptor messenger ribonucleic acid levels and densities in gastrointestinal muscle layers from healthy dairy cows

Author

Ontsouka, E.C., Blum, J.W., Steiner, A., and Meylan, M.

Subjects
Cows -- Research, Cows -- Genetic aspects, Cows -- Physiological aspects, Messenger RNA -- Research, Serotonin -- Receptors, Serotonin -- Research, Zoology and wildlife conservation
Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is involved in gastrointestinal tract (GIT) motor functions through binding to specific receptors located in the GIT walls. The objectives of the current study were to compare mRNA levels and binding sites of 5-H[T.sub.4] receptors (5-HT[R.sub.4]) in smooth muscle layers from the fundus abomasi, pylorus, ileum, cecum, proximal loop of the ascending colon (PLAC), and external loop of the spiral colon (ELSC) of healthy dairy cows, and to verify whether mRNA and protein expression were correlated. Smooth muscle samples were prepared by scraping the mucosa and submucosa from full-thickness intestinal wall samples. The mRNA levels of 5-HT[R.sub.4] were measured by real-time PCR and expressed relative to those of the housekeeping gene glyceralde-hyde phosphate dehydrogenase. Binding studies were performed using the 5-HT[R.sub.4] antagonist [[.sup.3]H] GR113808. The mRNA levels of 5-HT[R.sub.4] were affected (P < 0.05) by location along the GIT. The mRNA levels of 5-HT[R.sub.4] in the ELSC and the ileum were greater than in the PLAC (P = 0.05 and P = 0.07, respectively) but similar to those of all other locations. The competitive binding of [[.sup.3]H]GR113808 to suspended membranes from the fundus abomasi, pylorus, cecum, and ELSC was best fit by a 2-site receptor model, whereas it was best fit by a 1-site receptor model in the ileum and PLAC. The mRNA levels and numbers of 5-HT[R.sub.4] were not correlated (r = 0.14; P = 0.71). In conclusion, mRNA and binding sites for 5-HT[R.sub.4] are present in the smooth muscle layer of the entire GIT of dairy cows and may play a role with respect to motility. The effects of activation of this receptor subtype may be different among GIT locations due to differences in the amount of high-relative to low-affinity binding sites. Key words: dairy cow, gastrointestinal tract, 5-hydroxytryptamine (serotonin) receptor

Published
2006

61. 700O Kidney ccRCC immune classification (KIC) enhances the predictive value of T effector (Teff) and angiogenesis (Angio) signatures in response to nivolumab (N)

Author

Meylan, M., primary, Beuselinck, B., additional, Dalban, C., additional, Vano, Y., additional, Rioux Leclercq, N., additional, Sautès-Fridman, C., additional, Roussel, E., additional, Verbiest, A., additional, Chaput, N., additional, Terry, S., additional, Chevreau, C., additional, Gross-Goupil, M., additional, Fléchon, A., additional, Laguerre, B., additional, Chabaud, S., additional, Tantot, F., additional, Lambrechts, D., additional, Escudier, B., additional, Fridman, W-H., additional, and Albiges, L., additional

Published
2020
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66. Scattering of flexural-gravity waves by a crack in a floating ice sheet due to mode conversion during blocking.

Author

Barman, S. C., Das, S., Sahoo, T., and Meylan, M. H.

Subjects
ICE sheets, SCATTERING (Physics), FLEXURAL vibrations (Mechanics), S-matrix theory, DISPERSION relations, GROUP velocity
Abstract

The scattering of flexural-gravity waves in a thin floating plate is investigated in the presence of compression. In this case, wave blocking occurs, which is associated with both a zero in the group velocity and coalition of two or more roots of the related dispersion relation. There exists a region in the frequency space in which there are three real roots of the dispersion equation and hence three propagating modes. This multiplicity leads to mode conversion when scattering occurs. In one of these modes, the energy propagation direction is opposite to the wavenumber, making enforcement of the Sommerfeld radiation condition challenging. The focus here is on a canonical problem in flexural-gravity wave scattering, the scattering of waves by a crack. Formulae are developed that apply uniformly at all frequencies, including through the blocking frequencies. This solution is developed by tracking the movement of the dispersion relation roots carefully in the complex plane. The mode conversion is verified by the scattering matrix of the process and through an energy identity. This energy identity for the case of more than one progressive modes is established using Green’s theorem and later applied in the scattering matrix to identify the incident and transmitted waves in the scattering process and derive the radiation condition. Appropriate scaling of the reflection and transmission coefficients are provided with the energy identity. The solution method is illustrated with numerical examples. [ABSTRACT FROM AUTHOR]

Published
2021
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67. AntibioticScout.ch: Entscheidungshilfe für den umsichtigen Einsatz von antimikrobiellen Wirkstoffen: Anwendung beim Rind

Author

Peter, R, Müntener, Cedric R, Demuth, Daniel C, Heim, D, Stucki, F, Mevissen, Meike, Gerspach, Christian, Kaske, M, Steiner, A, Meylan, M, Bodmer, M, Schüpbach-Regula, G, Feldmann, M, Naegeli, Hanspeter, University of Zurich, and Peter, R

Subjects
Nutztiere, antibiotic resistance, decision support, 630 Agriculture, Entscheidungshilfe, 3400 General Veterinary, antimicrobial agents, 10079 Institute of Veterinary Pharmacology and Toxicology, Prävention, Rind, 10187 Department of Farm Animals, livestock, prevention, cattle, Antibiotikaresistenz, 570 Life sciences, biology, antimikrobielle Wirkstoffe
Published
2018

68. Die Bedeutung der Cryptosporidiose für die Kälbergesundheit in der Schweiz

Author

Olias, P, Dettwiler, I, Hemphill, A, Deplazes, P, Steiner, A, Meylan, M, University of Zurich, and Olias, P

Subjects
10078 Institute of Parasitology, Kalb, diarrhée du veau, calf, Cryptosporidiose, Bovins, cryptosporidiosis, veau, 3400 General Veterinary, Kälberdurchfall, diarrhea, diarrhée, Cryptosporidium, 610 Medicine & health, criptosporidiosi, calf diarrhea, Bovini, Rind, diarrea del vitello, vitello, 600 Technology, diarrea, 570 Life sciences, biology, Diarrhoe, Beef
Published
2018

83. DISCUSSION

Author

Mastellone, M., Margolin, M., Soulié, Mlle, Reulos, M., Delumeau, M., Stauffer, M., Labrousse, Vogler, M., Meylan, M., Dubief, M., and Estebe

Published
1974

84. DISCUSSION

Author

Bataillon, M., Stauffer, M., Margolin, M., Cantineau, M., Chamaran, Saint, Shimizu-Stuveras, Soulié, Mlle, Meylan, M., Allier, Jacques, Robert, Daniel, Delteil, Frank, Dricot, Abbé Michel, Kingdon, Robert, Dufour, Alain, Stauffer, Richard, Dufour, M., Robert, M., Boase, Alain, Rott, Jean, Rott, M., and Makkai, Laslzo

Published
1974

85. DISCUSSION

Author

François, M., Meylan, M., Allier, M., Cloulas, M., Soulié, Mlle, Orban, Mlle, Venard, M., Dufour, M., Kingdon, M., Delteil, M., and Wemyss, Alice Cunnack

Published
1974

86. DISCUSSION

Author

Dubief, M., Monnier, M., Robert, M., Reulos, M., Estèbe, Delteil, M., Venard, M., Méjan, M., Soulié, Mlle, Cunnack-Wemyss, Alice, Rott, M., Stauffer, M., Sutherland, Braekman, M., Jacquiot, Mlle, Weber, Mlle, Margolin, M., Meylan, M., Guey, M., and Labrousse

Published
1974

97. Sea state and boundary layer physics of the emerging arctic ocean

Author

Thomson, J., Squire, V., Ackley, S., Rogers, E., Babanin, Alexander, Guest, P., Maksym, T., Wadhams, P., Stammerjohn, S., Fairall, C., Perrson, O., Doble, M., Graber, H., Shen, H., Gemmrich, J., Lehner, Susanne, Holt, B., Williams, T., Meylan, M., and Bidlot, J.

Subjects
Beaufort Sea, Arctic Ocean, marginal ice zone, Chukchi Sea, sea ice
Published
2013

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