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793 results on '"Meng, Fenghua"'

77. Bioresponsive Chimaeric Polymersomes Mediate Sustained and Liver-Specific siRNATransfection In Vivo

Author

Huang, Ri, Wang, Feifei, Fu, He, Qi, Xinming, Xing, Guozhen, Ren, Jin, Cheng, Liang, Meng, Fenghua, and Zhong, Zhiyuan

Abstract

The silencing of disease-causing genes with small interfering RNA (siRNA) offers a particularly effective therapeutic strategy for different disorders; however, its clinical efficacy relies on the development of nontoxic and tissue-specific delivery vehicles. Herein, we report that bioresponsive chimaeric polymersomes (BCP) with short poly(ethylenimine) as inner shell mediate highly efficacious, sustained, and liver-specific siRNAtransfection in vivo. BCP exhibited remarkable encapsulation efficiencies of siRNA(95–100%) at siRNA-feeding contents of 15–25 wt %, to afford stable, small-sized (55–64 nm), and neutral-charged BCP-siRNA. siApoB-Loaded BCP (BCP-siApoB) outperformed lipofectamine counterparts and silenced 93% of ApoBmRNA in HepG2 cells at 50 nM siApoBwithout inducing cytotoxicity. Intriguingly, the in vivostudies using wild-type C57BL/6 mice revealed that BCP-siApoBpreferentially accumulated in the liver, and a single dose of 4.5 mg/kg achieved over 90% downregulation of ApoBmRNA for at least 10 days. The systemic administration of BCP-siApoBat 4.5 mg/kg every 2 weeks or 1.5 mg/kg weekly in diet-induced obese mice could also achieve up to 80% silencing of ApoBmRNA. The liver specificity and silencing efficacy of BCP-siApoBcould further be improved by decorating it with the trivalent N-acetylgalactosamine (TriGalNAc) ligand. These bioresponsive and liver-specific chimaeric polymersomes provide an enabling technology for siRNAtherapy of various liver-related diseases.

Published
2023
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85. Across-Cancer Immune Responses Induced by Nanovaccines or Microvaccines to Prevent Different Cancers and Cancer Metastasis

Author

Diao, Lu, primary, Ma, Lin, additional, Cheng, Junping, additional, Pan, Yunzhi, additional, Peng, Zuofu, additional, Li, Yupei, additional, Zhang, Xuenong, additional, Zhang, Lianjun, additional, Jiang, Honglv, additional, Xu, Guoqiang, additional, Meng, Fenghua, additional, Zhong, Zhiyuan, additional, and Liu, Mi, additional

Published
2022
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90. Immunotherapy and Prevention of Cancer by Nanovaccines Loaded with Whole‐Cell Components of Tumor Tissues or Cells (Adv. Mater. 43/2021)

Author

Ma, Lin, primary, Diao, Lu, additional, Peng, Zuofu, additional, Jia, Yun, additional, Xie, Huimin, additional, Li, Baisong, additional, Ma, Jianting, additional, Zhang, Meng, additional, Cheng, Lifang, additional, Ding, Dawei, additional, Zhang, Xuenong, additional, Chen, Huabing, additional, Mo, Fengfeng, additional, Jiang, Honglv, additional, Xu, Guoqiang, additional, Meng, Fenghua, additional, Zhong, Zhiyuan, additional, and Liu, Mi, additional

Published
2021
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97. Biodegradable polymersomes with structure Inherent fluorescence and targeting capacity for enhanced photo-dynamic therapy

Author

Cao, Shoupeng, Xia, Yifeng, Shao, Jingxin, Guo, Beibei, Dong, Yangyang, Pijpers, Imke A.B., Zhong, Zhiyuan, Meng, Fenghua, Abdelmohsen, Loai K.E.A., Williams, David S., van Hest, Jan C.M., Cao, Shoupeng, Xia, Yifeng, Shao, Jingxin, Guo, Beibei, Dong, Yangyang, Pijpers, Imke A.B., Zhong, Zhiyuan, Meng, Fenghua, Abdelmohsen, Loai K.E.A., Williams, David S., and van Hest, Jan C.M.

Abstract

Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features of loading capacity, emission brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, which self-assembled into well-defined polymersomes. The resultant AIEgenic polymersomes are intrinsically fluorescent delivery vehicles. The presence of the pyridinium moiety endows the polymersomes with mitochondrial targeting ability, which improves the efficiency of co-encapsulated photosensitizers and improves therapeutic index against cancer cells both in vitro and in vivo. This contribution showcases the ability to engineer AIEgenic polymersomes with structure inherent fluorescence and targeting capacity for enhanced photodynamic therapy.

Published
2021

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