5,866 results on '"Mebazaa A"'
Search Results
52. High Circulating Dipeptidyl Peptidase 3 Predicts Mortality and Need for Organ Support in Cardiogenic Shock: An Ancillary Analysis of the ACCOST-HH Trial
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PICOD, ADRIEN, NORDIN, HUGO, JARCZAK, DOMINIK, ZELLER, TANJA, ODDOS, CLAIRE, SANTOS, KARINE, HARTMANN, OLIVER, HERPAIN, ANTOINE, MEBAZAA, ALEXANDRE, KLUGE, STEFAN, AZIBANI, FERIEL, and KARAKAS, MAHIR
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- 2024
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53. Conséquences à l’adolescence des violences sexuelles dans l’enfance : penser le repérage au cours de l’hospitalisation pédopsychiatrique des adolescents
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d’Harcourt, B., Mebazaa, C., Gilsanz, M., Nadereau, L., Leble, N., and Rappaport, C.
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- 2024
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54. Left ventricular ejection fraction digit bias and reclassification of heart failure with mildly reduced vs reduced ejection fraction based on the 2021 definition and classification of heart failure
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Savarese, Gianluigi, Gatti, Paolo, Benson, Lina, Adamo, Marianna, Chioncel, Ovidiu, Crespo-Leiro, Maria G., Anker, Stefan D., Coats, Andrew J.S., Filippatos, Gerasimos, Lainscak, Mitja, McDonagh, Theresa, Mebazaa, Alexandre, Metra, Marco, Piepoli, Massimo F., Rosano, Giuseppe M.C., Ruschitzka, Frank, Seferovic, Petar, Volterrani, Maurizio, Maggioni, Aldo P., and Lund, Lars H.
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- 2024
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55. Management of Acute Right Ventricular Failure
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Asakage, Ayu, Bækgaard, Josefine, Mebazaa, Alexandre, and Deniau, Benjamin
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- 2023
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56. Radiomic analysis of abdominal organs during sepsis of digestive origin in a French intensive care unit
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Louis Boutin, Louis Morisson, Florence Riché, Romain Barthélémy, Alexandre Mebazaa, Philippe Soyer, Benoit Gallix, Anthony Dohan, and Benjamin G Chousterman
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acute kidney injury ,computed tomography ,image processing ,intensive care unit ,sepsis ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Background Sepsis is a severe and common cause of admission to the intensive care unit (ICU). Radiomic analysis (RA) may predict organ failure and patient outcomes. The objective of this study was to assess a model of RA and to evaluate its performance in predicting in-ICU mortality and acute kidney injury (AKI) during abdominal sepsis. Methods This single-center, retrospective study included patients admitted to the ICU for abdominal sepsis. To predict in-ICU mortality or AKI, elastic net regularized logistic regression and the random forest algorithm were used in a five-fold cross-validation set repeated 10 times. Results Fifty-five patients were included. In-ICU mortality was 25.5%, and 76.4% of patients developed AKI. To predict in-ICU mortality, elastic net and random forest models, respectively, achieved areas under the curve (AUCs) of 0.48 (95% confidence interval [CI], 0.43–0.54) and 0.51 (95% CI, 0.46–0.57) and were not improved combined with Simplified Acute Physiology Score (SAPS) II. To predict AKI with RA, the AUC was 0.71 (95% CI, 0.66–0.77) for elastic net and 0.69 (95% CI, 0.64–0.74) for random forest, and these were improved combined with SAPS II, respectively; AUC of 0.94 (95% CI, 0.91–0.96) and 0.75 (95% CI, 0.70–0.80) for elastic net and random forest, respectively. Conclusions This study suggests that RA has poor predictive performance for in-ICU mortality but good predictive performance for AKI in patients with abdominal sepsis. A secondary validation cohort is needed to confirm these results and the assessed model.
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- 2023
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57. Distinct host-response signatures in circulatory shock: a narrative review
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Sabri Soussi, Claudia dos Santos, Jacob C. Jentzer, Alexandre Mebazaa, Etienne Gayat, Janine Pöss, Hannah Schaubroeck, Filio Billia, John C. Marshall, and Patrick R. Lawler
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Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Circulatory shock is defined syndromically as hypotension associated with tissue hypoperfusion and often subcategorized according to hemodynamic profile (e.g., distributive, cardiogenic, hypovolemic) and etiology (e.g., infection, myocardial infarction, trauma, among others). These shock subgroups are generally considered homogeneous entities in research and clinical practice. This current definition fails to consider the complex pathophysiology of shock and the influence of patient heterogeneity. Recent translational evidence highlights previously under-appreciated heterogeneity regarding the underlying pathways with distinct host-response patterns in circulatory shock syndromes. This heterogeneity may confound the interpretation of trial results as a given treatment may preferentially impact distinct subgroups. Re-analyzing results of major ‘neutral’ treatment trials from the perspective of biological mechanisms (i.e., host-response signatures) may reveal treatment effects in subgroups of patients that share treatable traits (i.e., specific biological signatures that portend a predictable response to a given treatment). In this review, we discuss the emerging literature suggesting the existence of distinct biomarker-based host-response patterns of circulatory shock syndrome independent of etiology or hemodynamic profile. We further review responses to newly prescribed treatments in the intensive care unit designed to personalize treatments (biomarker-driven or endotype-driven patient selection in support of future clinical trials).
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- 2023
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58. Global differences in acute heart failure treatment: analysis of the STRONG‐HF site feasibility questionnaire
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Maria Novosadova, Lauren Gianchetti, Koji Takagi, Priyanka Morishetty, Lauren Gaeta, Christopher Edwards, Beth A. Davison, Adrien Picod, Alexandre Mebazaa, and Gad Cotter
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Acute heart failure ,Feasibility questionnaire ,Regions ,Adherence ,Guidelines ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Acute heart failure (AHF) has an impact on human health worldwide. Despite guidelines for treatment and management of AHF, mortality rates remain high. The main objective of this study was to compare standard in‐hospital treatment and management of AHF against current clinical guidelines and variations across regions. Methods Between February 2018 and May 2021, investigators were approached to participate in the STRONG‐HF study. The lead investigator at 158 sites in 20 countries completed a site feasibility questionnaire. Sites were grouped by country into five different regions: Africa and the Middle East, Eastern Europe, Russia, South America, and Western Europe. Results According to the questionnaires, there are large differences in how patients present due to AHF and where in the hospital they are treated. There were significant differences in reported percentage of AHF patients receiving angiotensin converting enzymes inhibitors across the regions (P
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- 2023
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59. Ketamine restriction correlates with reduced cholestatic liver injury and improved outcomes in critically ill patients with burn injury
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Christian De Tymowski, François Dépret, Emmanuel Dudoignon, Nabila Moreno, Anne-Marie Zagdanski, Kyann Hodjat, Benjamin Deniau, Alexandre Mebazaa, Matthieu Legrand, and Vincent Mallet
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Ketamine ,Cholestatic liver injury ,Drug-induced liver injury ,Drug toxicity ,Mortality ,Burn injury ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Ketamine-associated cholestatic liver injury is reported in patients with severe burn injury, but its association with patient outcome is unclear. We investigated the relationship between ketamine exposure, cholestatic liver injury, and outcome of critically ill patients with burn injury. Methods: In a retrospective study, patients with severe burn injury were analysed across two periods: unrestricted ketamine prescription (ketamine-liberal) and capped ketamine dosage (ketamine-restricted). The primary endpoint was cholestatic liver injury, and the secondary endpoint was 3-month mortality. Binary logistic regression models and the revised electronic causality assessment method were used to measure the strength of associations and causality assessment, respectively. Results: Of 279 patients (median age 51 [IQR 31–67] years; 63.1% men; burned surface area 28.5%, IQR 20–45%), 155 (56%) were in the ketamine-liberal group, and 124 (44%) were in the ketamine-restricted group, with comparable clinical characteristics, except for ketamine exposure (median doses 265.0 [IQR 0–8,021] mg and 20 [IQR 0–105] mg, respectively; p
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- 2024
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60. Proteomic Profiling in Patients With Peripartum Cardiomyopathy: A Biomarker Study of the ESC EORP PPCM Registry
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Kodogo, Vitaris, Viljoen, Charle, Hoevelmann, Julian, Chakafana, Graham, Tromp, Jasper, Farhan, Hasan Ali, Goland, Sorel, van der Meer, Peter, Karaye, Kamilu, Kryczka, Karolina, Hilfiker-Kleiner, Denise, Jackson, Alice, Mebazaa, Alexandre, Böhm, Michael, Pieske, Burkert, Bauersachs, Johann, Bell, Liam, and Sliwa, Karen
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- 2023
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61. The benefits of the video-laryngoscope in learning intubation for undergraduate medical students: A randomized crossover study in airway manikin
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Haddad, Faten, Trabelsi, Yasmine, Jebri, Alia, Hafien, Abdelmajid, Becheikh, Khalil, Trabelsi, Becem, and Mebazaa, Mhamed Sami
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- 2023
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62. Performance evaluation of a PCR panel (FilmArray® Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: A systematic review and meta-analysis
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Gastli, Nabil, Cattoir, Vincent, Maataoui, Naouale, Armand-Lefèvre, Laurence, Mitton, Barend, Hoover, Jonathan, Greenland, John R., Posteraro, Brunella, Sanguinetti, Maurizio, Kyriazopoulou, Evdoxia, Giamarellos-Bourboulis, Evangelos J., Menchinelli, Giulia, Joannard, Brune, Moy, Anne-Clotilde, Kimmoun, Antoine, Merkling, Thomas, Berçot, Béatrice, Caméléna, François, Poncin, Thibaut, Deniau, Benjamin, Mebazaa, Alexandre, Dudoignon, Emmanuel, and Dépret, François
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- 2023
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63. Relationship between positive end-expiratory pressure levels, central venous pressure, systemic inflammation and acute renal failure in critically ill ventilated COVID-19 patients: a monocenter retrospective study in France
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Pierre Basse, Louis Morisson, Romain Barthélémy, Nathan Julian, Manuel Kindermans, Magalie Collet, Benjamin Huot, Etienne Gayat, Alexandre Mebazaa, and Benjamin G. Chousterman
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acute kidney injury ,central venous pressure ,covid-19 ,inflammation ,positive end-expiratory pressure ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Background The role of positive pressure ventilation, central venous pressure (CVP) and inflammation on the occurrence of acute kidney injury (AKI) have been poorly described in mechanically ventilated patient secondary to coronavirus disease 2019 (COVID-19). Methods This was a monocenter retrospective cohort study of consecutive ventilated COVID-19 patients admitted in a French surgical intensive care unit between March 2020 and July 2020. Worsening renal function (WRF) was defined as development of a new AKI or a persistent AKI during the 5 days after mechanical ventilation initiation. We studied the association between WRF and ventilatory parameters including positive end-expiratory pressure (PEEP), CVP, and leukocytes count. Results Fifty-seven patients were included, 12 (21%) presented WRF. Daily PEEP, 5 days mean PEEP and daily CVP values were not associated with occurrence of WRF. 5 days mean CVP was higher in the WRF group compared to patients without WRF (median [IQR], 12 mm Hg [11-13] vs. 10 mm Hg [9–12]; P=0.03). Multivariate models with adjustment on leukocytes and Simplified Acute Physiology Score (SAPS) II confirmed the association between CVP value and risk of WRF (odd ratio, 1.97; 95% confidence interval, 1.12–4.33). Leukocytes count was also associated with occurrence of WRF in the WRF group (14 G/L [11–18]) and the no-WRF group (9 G/L [8–11]) (P=0.002). Conclusions In mechanically ventilated COVID-19 patients, PEEP levels did not appear to influence occurrence of WRF. High CVP levels and leukocytes count are associated with risk of WRF.
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- 2023
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64. Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial
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Asfar, Pierre, Nay, Mai-Anh, Guitton, Christophe, Quenot, Jean-Pierre, Tran-Van, David, Bohe, Julien, Plantefève, Gaëtan, Nseir, Saadalla, Lefrant, Jean-Yves, Monnet, Xavier, Papazian, Laurent, Vinsonneau, Christophe, Constantin, Jean-Michel, Mebazaa, Alexandre, Oueslati, Haikel, Escudero, Dolores, Martinez Sagasti, Fernando, Piacentini, Enrique, Ramirez Galleymore, Paula, Dugernier, Thierry, Fagnoul, David, Michaux, Isabelle, Seibert, Allan, Reinikainen, Matti, Grøfte, Thorbjørn, Martin-Loeches, Ignacio, Laffey, John, François, Bruno, Lambden, Simon, Fivez, Tom, Gibot, Sebastien, Derive, Marc, Grouin, Jean-Marie, Salcedo-Magguilli, Margarita, Lemarié, Jérémie, De Schryver, Nicolas, Jalkanen, Ville, Hicheur, Tarik, Garaud, Jean-Jacques, Cuvier, Valérie, Ferrer, Ricard, Bestle, Morten, Pettilä, Ville, Mira, Jean-Paul, Bouisse, Camille, Mercier, Emmanuelle, Vermassen, Joris, Huberlant, Vincent, Vinatier, Isabelle, Anguel, Nadia, Levy, Mitchell, and Laterre, Pierre-François
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- 2023
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65. Repurposing electroencephalogram monitoring of general anaesthesia for building biomarkers of brain ageing: an exploratory study
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Sabbagh, David, Cartailler, Jérôme, Touchard, Cyril, Joachim, Jona, Mebazaa, Alexandre, Vallée, Fabrice, Gayat, Étienne, Gramfort, Alexandre, and Engemann, Denis A.
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- 2023
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66. Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients
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Dépret, François, Amzallag, Juliette, Pollina, Adrien, Fayolle-Pivot, Laure, Coutrot, Maxime, Chaussard, Maïté, Santos, Karine, Hartmann, Oliver, Jully, Marion, Fratani, Alexandre, Oueslati, Haikel, Cupaciu, Alexandru, Benyamina, Mourad, Guillemet, Lucie, Deniau, Benjamin, Mebazaa, Alexandre, Gayat, Etienne, Farny, Boris, Textoris, Julien, and Legrand, Matthieu
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Kidney Disease ,Physical Injury - Accidents and Adverse Effects ,Good Health and Well Being ,Acute Kidney Injury ,Aged ,Burns ,Cohort Studies ,Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ,Female ,Humans ,Male ,Middle Aged ,Patient Admission ,Prognosis ,Prospective Studies ,Risk Factors ,Severity of Illness Index ,Shock ,Dipeptidyl peptidase-3 ,Burn patients ,Mortality ,Acute kidney injury ,Biomarkers ,PRONOBURN group ,Medical and Health Sciences ,Emergency & Critical Care Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundDipeptidyl peptidase-3 (DPP3) is a metallopeptidase which cleaves bioactive peptides, notably angiotensin II, and is involved in inflammation regulation. DPP3 has been proposed to be a myocardial depressant factor and to be involved in circulatory failure in acute illnesses, possibly due to angiotensin II cleavage. In this study, we evaluated the association between plasmatic DPP3 level and outcome (mortality and hemodynamic failure) in severely ill burn patients.MethodsIn this biomarker analysis of a prospective cohort study, we included severely ill adult burn patients in two tertiary burn intensive care units. DPP3 was measured at admission (DPP3admin) and 3 days after. The primary endpoint was 90-day mortality. Secondary endpoints were hemodynamic failure and acute kidney injury (AKI).ResultsOne hundred and eleven consecutive patients were enrolled. The median age was 48 (32.5-63) years, with a median total body surface area burned of 35% (25-53.5) and Abbreviated Burn Severity Index (ABSI) of 8 (7-11). Ninety-day mortality was 32%. The median DPP3admin was significantly higher in non-survivors versus survivors (53.3 ng/mL [IQR 28.8-103.5] versus 27.1 ng/mL [IQR 19.4-38.9]; p
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- 2020
67. Acute Heart Failure Is a Malignant Process: But We Can Induce Remission
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Gad Cotter, Beth A. Davison, Carolyn S. P. Lam, Marco Metra, Piotr Ponikowski, John R. Teerlink, and Alexandre Mebazaa
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acute heart failure ,medications ,remission induction ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
ABSTRACT Acute heart failure is a common and increasingly prevalent condition, affecting >10 million people annually. For those patients who survive to discharge, early readmissions and death rates are >30% everywhere on the planet, making it a malignant condition. Beyond these adverse outcomes, it represents one of the largest drivers of health care costs globally. Studies in the past 2 years have demonstrated that we can induce remissions in this malignant process if therapy is instituted rapidly, at the first acute heart failure episode, using full doses of all available effective medications. Multiple studies have demonstrated that this goal can be achieved safely and effectively. Now the urgent call is for all stakeholders, patients, physicians, payers, politicians, and the public at large to come together to address the gaps in implementation and enable health care providers to induce durable remissions in patients with acute heart failure.
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- 2023
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68. Repurposing electroencephalogram monitoring of general anaesthesia for building biomarkers of brain ageing: an exploratory study
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David Sabbagh, Jérôme Cartailler, Cyril Touchard, Jona Joachim, Alexandre Mebazaa, Fabrice Vallée, Étienne Gayat, Alexandre Gramfort, and Denis A. Engemann
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brain age ,burst suppression ,electroencephalogram (EEG) ,general anaesthesia ,machine learning ,propofol ,Anesthesiology ,RD78.3-87.3 - Abstract
Background: Electroencephalography (EEG) is increasingly used for monitoring the depth of general anaesthesia, but EEG data from general anaesthesia monitoring are rarely reused for research. Here, we explored repurposing EEG monitoring from general anaesthesia for brain-age modelling using machine learning. We hypothesised that brain age estimated from EEG during general anaesthesia is associated with perioperative risk. Methods: We reanalysed four-electrode EEGs of 323 patients under stable propofol or sevoflurane anaesthesia to study four EEG signatures (95% of EEG power
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- 2023
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69. Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support: A Practical Approach
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Van Edom, Charlotte J., Gramegna, Mario, Baldetti, Luca, Beneduce, Alessandro, Castelein, Thomas, Dauwe, Dieter, Frederiks, Pascal, Giustino, Gennaro, Jacquemin, Marc, Janssens, Stefan P., Panoulas, Vasileios F., Pöss, Janine, Rosenberg, Alexander, Schaubroeck, Hannah A.I., Schrage, Benedikt, Tavazzi, Guido, Vanassche, Thomas, Vercaemst, Leen, Vlasselaers, Dirk, Vranckx, Pascal, Belohlavek, Jan, Gorog, Diana A., Huber, Kurt, Mebazaa, Alexandre, Meyns, Bart, Pappalardo, Federico, Scandroglio, Anna M., Stone, Gregg W., Westermann, Dirk, Chieffo, Alaide, Price, Susanna, and Vandenbriele, Christophe
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- 2023
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70. Impact of Early Out-of-Bed Mobilization on Functional Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Cohort Study
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Foudhaili, Adéla, Barthélémy, Romain, Collet, Magalie, de Roquetaillade, Charles, Kerever, Sébastien, Vitiello, Damien, Mebazaa, Alexandre, and Chousterman, Benjamin G.
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- 2023
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71. Accuracy of a multiparametric score based on pulse wave analysis for prediction of fluid responsiveness: ancillary analysis of an observational study
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Neuschwander, Arthur, Barthélémy, Romain, Ditchi, David, Dramé, Fatou, Redouté, Maximilien, Stern, Jules, Cholley, Bernard, Mebazaa, Alexandre, Chousterman, Benjamin Glenn, and Pirracchio, Romain
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Biomedical and Clinical Sciences ,Clinical Sciences ,Cardiovascular ,Clinical Research ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Aged ,Blood Pressure ,Cardiac Output ,Female ,Fluid Therapy ,Hemodynamics ,Humans ,Male ,Middle Aged ,Prospective Studies ,Pulse Wave Analysis ,Respiration ,Artificial ,Stroke Volume ,pressure recording analytical method ,pulse contour ,fluid responsiveness ,cardiac output ,Anesthesiology ,Clinical sciences - Abstract
PurposeThe pressure recording analytical method (PRAM) monitor is a non-invasive pulse contour cardiac output (CO) device that cannot be considered interchangeable with the gold standard for CO estimation. It, however, generates additional hemodynamic indices that need to be evaluated. Our objective was to investigate the performance of a multiparametric predictive score based on a combination of several parameters generated by the PRAM monitor to predict fluid responsiveness.MethodsSecondary analysis of a prospective observational study from April 2016 to December 2017 in two French teaching hospitals. We included critically ill patients who were monitored by esophageal Doppler monitoring and an invasive arterial line, and received a 250-500 mL crystalloid fluid challenge. The main outcome measure was the predictive score discrimination evaluated by the area under the receiver operating characteristics curve.ResultsThe three baseline PRAM-derived parameters associated with fluid responsiveness in univariate analysis were pulse pressure variation, cardiac cycle efficiency, and arterial elastance (P
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- 2020
72. Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19.
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Dudoignon, Emmanuel, Moreno, Nabila, Deniau, Benjamin, Coutrot, Maxime, Longer, Romain, Amiot, Quentin, Mebazaa, Alexandre, Pirracchio, Romain, Depret, François, and Legrand, Matthieu
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Humans ,Pneumonia ,Viral ,Coronavirus Infections ,Critical Illness ,Creatinine ,Aldosterone ,Renin-Angiotensin System ,Aged ,Middle Aged ,Intensive Care Units ,Female ,Male ,Acute Kidney Injury ,Pandemics ,Betacoronavirus ,COVID-19 ,SARS-CoV-2 ,Renin-angiotensin-aldosterone system ,Pneumonia ,Viral - Abstract
The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV-2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI.
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- 2020
73. Impact of renin-angiotensin system inhibitors continuation versus discontinuation on outcome after major surgery: protocol of a multicenter randomized, controlled trial (STOP-or-NOT trial)
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Legrand, Matthieu, Futier, Emmanuel, Leone, Marc, Deniau, Benjamin, Mebazaa, Alexandre, Plaud, Benoît, Coriat, Pierre, Rossignol, Patrick, Vicaut, Eric, and Gayat, Etienne
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Patient Safety ,Cardiovascular ,Comparative Effectiveness Research ,Clinical Research ,Hypertension ,Heart Disease ,5.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Development of treatments and therapeutic interventions ,6.4 Surgery ,6.1 Pharmaceuticals ,Angiotensin Receptor Antagonists ,Angiotensin-Converting Enzyme Inhibitors ,Drug Administration Schedule ,France ,Heart Failure ,Humans ,Multicenter Studies as Topic ,Perioperative Care ,Postoperative Complications ,Randomized Controlled Trials as Topic ,Renin-Angiotensin System ,Risk Factors ,Time Factors ,Treatment Outcome ,STOP-OR-NOT study investigators ,ACE inhibitors ,ARB ,Acute kidney injury ,Complications ,Mortality ,Outcome ,Strategy ,Surgery ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,General & Internal Medicine ,Clinical sciences ,Epidemiology ,Health services and systems - Abstract
BackgroundChronic treatment of hypertension or heart failure very often includes an angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) as renin-angiotensin system inhibitors (RASi) treatments. To stop or not to stop these medications before major surgery remains an unresolved issue. The lack of evidence leads to conflicting guidelines with respect to RASi management before major surgery. The purpose of this study is to evaluate the impact of a strategy of RASi continuation or discontinuation on perioperative complications in patients undergoing major non-cardiac surgery.MethodsThis is a multicenter, open-labeled randomized controlled trial in > 30 French centers. In the experimental group, RASi will be continued while the treatment will be stopped 48 h before the surgery in the control arm. The primary endpoint is a composite endpoint of major complications after surgery. An endpoint adjudication committee will review clinical data and adjudicate efficacy endpoints while blinded to the assigned study drug group. Main analysis will be by intention-to-treat comparing the composite outcome measure at 28 days in the two groups. A total of 2222 patients are planned to detect an absolute complications difference of 5%.DiscussionThe results of the trial should provide robust evidence to anesthesiologists and surgeons regarding management of RASi before major non-cardiac surgery.Trial registrationClinicalTrials.gov, NCT03374449 . Registered on 11 December 2017.
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- 2019
74. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
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Abrough, Fekri, Acharya, Subhash P, Amin, Pravin, Arabi, Yaseen, Aragao, Irene, Bauer, Philippe, Beduneau, Gaëtan, Beitler, Jeremy, Berkius, Johan, Bugedo, Guillermo, Camporota, Luigi, Cerny, Vladimir, Cho, Young-Jae, Clarkson, Kevin, Estenssoro, Elisa, Goligher, Ewan, Grasselli, Giacomo, Gritsan, Alexey, Hashemian, Seyed Mohammadreza, Hermans, Greet, Heunks, Leo M, Jovanovic, Bojan, Kurahashi, Kiyoyasu, Laake, Jon Henrik, Matamis, Dimitrios, Moerer, Onnen, Molnar, Zsolt, Ozyilmaz, Ezgi, Panka, Bernardo, Papali, Alfred, Peñuelas, Óscar, Perbet, Sébastien, Piquilloud, Lise, Qiu, Haibo, Razek, Assem Abdel, Rittayamai, Nuttapol, Roldan, Rollin, Serpa Neto, Ary, Szuldrzynski, Konstanty, Talmor, Daniel, Tomescu, Dana, Van Haren, Frank, Villagomez, Asisclo, Zeggwagh, Amine Ali, Abe, Toshikazu, Aboshady, Abdelrhman, Acampo-de Jong, Melanie, Acharya, Subhash, Adderley, Jane, Adiguzel, Nalan, Agrawal, Vijay Kumar, Aguilar, Gerardo, Aguirre, Gaston, Aguirre-Bermeo, Hernan, Ahlström, Björn, Akbas, Türkay, Akker, Mustafa, Al Sadeh, Ghamdan, Alamri, Sultan, Algaba, Angela, Ali, Muneeb, Aliberti, Anna, Allegue, Jose Manuel, Alvarez, Diana, Amador, Joaquin, Andersen, Finn H, Ansari, Sharique, Apichatbutr, Yutthana, Apostolopoulou, Olympia, Arellano, Daniel, Arica, Mestanza, Arikan, Huseyin, Arinaga, Koichi, Arnal, Jean-Michel, Asano, Kengo, Asín-Corrochano, Marta, Avalos Cabrera, Jesus Milagrito, Avila Fuentes, Silvia, Aydemir, Semih, Aygencel, Gulbin, Azevedo, Luciano, Bacakoglu, Feza, Badie, Julio, Baedorf Kassis, Elias, Bai, Gabriela, Balaraj, Govindan, Ballico, Bruno, Banner-Goodspeed, Valerie, Banwarie, Preveen, Barbieri, Rosella, Baronia, Arvind, Barrett, Jonathan, Barrot, Loïc, Barrueco-Francioni, Jesus Emilio, Barry, Jeffrey, Bawangade, Harshal, Beavis, Sarah, Beck, Eduardo, Beehre, Nina, Belenguer Muncharaz, Alberto, Bellani, Giacomo, Belliato, Mirko, Bellissima, Agrippino, Beltramelli, Rodrigo, Ben Souissi, Asma, Benitez-Cano, Adela, Benlamin, Mohamed, Benslama, Abdellatif, Bento, Luis, Benvenuti, Daniela, Bernabe, Laura, Bersten, Andrew, Berta, Giacomo, Bertini, Pietro, Bertram-Ralph, Elliot, Besbes, Mohamed, Bettini, Lisandro Roberto, Beuret, Pascal, Bewley, Jeremy, Bezzi, Marco, Bhakhtiani, Lakshay, Bhandary, Rakesh, Bhowmick, Kaushik, Bihari, Shailesh, Bissett, Bernie, Blythe, David, Bocher, Simon, Boedjawan, Narain, Bojanowski, Christine M, Boni, Elisa, Boraso, Sabrina, Borelli, Massimo, Borello, Silvina, Borislavova, Margarita, Bosma, Karen J, Bottiroli, Maurizio, Boyd, Owen, Bozbay, Suha, Briva, Arturo, Brochard, Laurent, Bruel, Cédric, Bruni, Andrea, Buehner, Ulrike, Bulpa, Pierre, Burt, Karen, Buscot, Mathieu, Buttera, Stefania, Cabrera, Jorge, Caccese, Roberta, Caironi, Pietro, Canchos Gutierrez, Ivan, Canedo, Nancy, Cani, Alma, Cappellini, Iacopo, Carazo, Jesus, Cardonnet, Luis Pablo, Carpio, David, Carriedo, Demetrio, Carrillo, Ramón, Carvalho, João, Caser, Eliana, Castelli, Antonio, Castillo Quintero, Manuel, Castro, Heloisa, 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Federico, Gouin, Philippe, Graf Santos, Jerónimo, Grainne, Rooney, Grando, Matilde, Granov Grabovica, Sanja, Grasso, Salvatore, Grasso, Rinaldo, Grimmer, Lisa, Grissom, Colin, Gu, Qing, Guan, Xiang-Dong, Guarracino, Fabio, Guasch, Neus, Guatteri, Luca, Gueret, Renaud, Guérin, Claude, Guerot, Emmanuel, Guitard, Pierre-Gildas, Gül, Fethi, Gumus, Ayca, Gurjar, Mohan, Gutierrez, Patricia, Hachimi, Abdelhamid, Hadzibegovic, Adi, Hagan, Samantha, Hammel, Clare, Han Song, Joo, Hanlon, Gabrielle, Heines, Serge, Henriksson, Johanna, Herbrecht, Jean-Etienne, Heredia Orbegoso, Gabriel Omar, Hermon, Andrew, Hernandez, Rosana, Hernandez, Carmen, Herrera, Luis, Herrera-Gutierrez, Manuel, Heunks, Leo, Hidalgo, Juan, Hill, Dianne, Holmquist, Dagmar, Homez, Marcela, Hongtao, Xia, Hormis, Anil, Horner, Daniel, Hornos, M Carmen, Hou, Meihong, House, Stacy, Housni, Brahim, Hugill, Keith, Humphreys, Sally, Humbert, Louis, Hunter, Stephanie, Hwa Young, Lee, Iezzi, Nicolas, Ilutovich, Santiago, Inal, Volkan, Innes, Richard, Ioannides, Panagiotis, Iotti, Giorgio Antonio, Ippolito, Mariachiara, Irie, Hiromasa, Iriyama, Hiroki, Itagaki, Taiga, Izura, Javier, Izza, Santiago, Jabeen, Rakhshanda, Jamaati, Hamidreza, Jamadarkhana, Sunil, Jamoussi, Amira, Jankowski, Milosz, Jaramillo, Luis Alberto, Jeon, Kyeongman, Jeong Lee, Seok, Jeswani, Deepak, Jha, Simant, Jiang, Liangyan, Jing, Chen, Jochmans, Sébastien, Johnstad, Bror Anders, Jongmin, Lee, Joret, Aurélie, Junhasavasdikul, Detajin, Jurado, Maria Teresa, Kam, Elisa, Kamohara, Hidenobu, Kane, Caroline, Kara, Iskender, Karakurt, Sait, Karnjanarachata, Cherdkiat, Kataoka, Jun, Katayama, Shinshu, Kaushik, Shuchi, Kelebek Girgin, Nermin, Kerr, Kathryn, Kerslake, Ian, Khairnar, Prakash, Khalid, Abidi, Khan, Akram, Khanna, Ashish K, Khorasanee, Reza, Kienhorst, Dieneke, Kirakli, Cenk, Knafelj, Rihard, Kol, Mark Kol, Kongpolprom, Napplika, Kopitko, Csaba, Korkmaz Ekren, Pervin, Kubisz-Pudelko, Agnieszka, Kulcsar, Zoltan, Kumasawa, Junji, Kuriyama, 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Martin, Felix, Martin, Alex, Martin Dal Gesso, Cristina, Martinez, Felipe, Martínez-Fidalgo, Conchita, Martin-Loeches, Ignacio, Mas, Arantxa, Masaaki, Sakuraya, Maseda, Emilio, Massa, Eleni, Mattsson, Anna, Maugeri, Jessica, McCredie, Victoria, McCullough, James, McGuinness, Shay, McKown, Andrew, Medve, László, Mei, Chengqing, Mellado Artigas, Ricard, Mendes, Vitor, Mervat, Mohamed Khalaf Ebraheim, Michaux, Isabelle, Mikhaeil, Michael, Milagros, Olga, Milet, Igor, Millan, Maria Teresa, Minwei, Zhang, Mirabella, Lucia, Mishra, Sanghamitra, Mistraletti, Giovanni, Mochizuki, Katsunori, Moghal, Arif, Mojoli, Francesco, Molin, Alexandre, Montiel, Raquel, Montini, Luca, Monza, Gianmario, Mora Aznar, Maria, Morakul, Sunthiti, Morales, Maria, Moreno Torres, Daniel, Morocho Tutillo, Diego Rolando, Motherway, Catherine, Mouhssine, Doumiri, Mouloudi, Eleni, Muñoz, Tapia, Munoz de Cabo, Carlos, Mustafa, Mohamed, Muthuchellappan, Radhakrishnan, Muthukrishnan, Muraleekrishnan, Muttini, Stefano, Nagata, Isao, Nahar, Dick, Nakanishi, Misuzu, Nakayama, Izumi, Namendys-Silva, Silvio Antonio, Nanchal, Rahul, Nandakumar, Sivakumar, Nasi, Alessandra, Nasir, Kamal, Navalesi, Paolo, Naz Aslam, Tayyba, Nga Phan, Thuy, Nichol, Alistair, Niiyama, Shuhei, Nikolakopoulou, Sofia, Nikolic, Elena, Nitta, Kenichi, Noc, Marko, Nonas, Stephanie, Nseir, Saad, Nur Soyturk, Ayse, Obata, Yukako, Oeckler, Richard, Oguchi, Moe, Ohshimo, Shinichiro, Oikonomou, Marina, Ojados, Agueda, Oliveira, Maria Teresa, Oliveira Filho, Wilson, Oliveri, Carlo, Olmos, Aitor, Omura, Kazuya, Orlandi, Maria Cristina, Orsenigo, Francesca, Ortiz-Ruiz De Gordoa, Laura, Ota, Kei, Ovalle Olmos, Rainier, Öveges, Nándo, Oziemski, Peter, Ozkan Kuscu, Ozlem, Pachas Alvarado, Fernando, Pagella, Gonzalo, Palaniswamy, Vijayanand, Palazon Sanchez, Eugenio Luis, Palmese, Salvatore, Pan, Guojun, Pan, Wensen, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Parekh, Ameet, Parke, Rachael, Parrilla, Francisco J, Parrilla, Dácil, Pasha, Taha, Pasin, Laura, Patão, Luis, Patel, Mayur, Patel, Grisma, Pati, Basanta Kumar, Patil, Jayaprakash, Pattnaik, Saroj, Paul, Daniel, Pavesi, Maurizio, Pavlotsky, Vanesa Alejandra, Paz, Graciela, Paz, Enrique, Pecci, Elisabetta, Pellegrini, Carlos, Peña Padilla, Andrea Gabriela, Perchiazzi, Gaetano, Pereira, Tiago, Pereira, Vera, Perez, Manuel, Perez Calvo, Cesar, Perez Cheng, Meisy, Perez Maita, Ronald, Pérez-Araos, Rodrigo, Perez-Teran, Purificación, Perez-Torres, David, Perkins, Gavin, Persona, Paolo, Petnak, Tananchai, Petrova, Marina, Pham, Tai, Philippart, François, Picetti, Edoardo, Pierucci, Elisabetta, Piervincenzi, Edoardo, Pinciroli, Riccardo, Pintado, Maria-Consuelo, Piraino, Thomas, Piras, Stephanie, Piras, Claudio, Pirompanich, Pattarin, Pisani, Luigi, Platas, Enrique, Plotnikow, Gustavo, Porras, Willy, Porta, Virginia, Portilla, Mariana, Portugal, José, Povoa, Pedro, Prat, Gwenael, Pratto, Romina, Preda, Gabriel, Prieto, Isidro, Prol-Silva, Estefania, Pugh, Richard, Qi, Yupeng, Qian, Chuanyun, Qin, Tiehe, Qu, Hongping, Quintana, Teobaldo, Quispe Sierra, Rosari, Quispe Soto, Rocio, Rabbani, Raihan, Rabee, Mohamed, Rabie, Ahmed, Rahe Pereira, Maria Augusta, Rai, Ashish, Raj Ashok, Sundar, Rajab, Mostafa, Ramdhani, Navin, Ramey, Elizabeth, Ranieri, Marco, Rathod, Darshana, Ray, Banambar, Redwanul Huq, Shihan Mahmud, Regli, Adrian, Reina, Rosa, Resano Sarmiento, Natalia, Reynaud, Faustine, Rialp, Gemma, Ricart, Pilar, Rice, Todd, Richardson, Angus, Rieder, Marcelo, Rinket, Martin, Rios, Fernando, Risso Vazquez, Alejandro, Riva, Ivano, Rivette, Monaly, Roca, Oriol, Roche-Campo, Ferran, Rodriguez, Covadonga, Rodriguez, Gabriel, Rodriguez Gonzalez, Daniel, Rodriguez Tucto, Xandra Yanina, Rogers, Angela, Romano, María Elena, Rørtveit, Linda, Rose, Alastair, Roux, Damien, Rouze, Anahita, Rubatto Birri, Paolo Nahuel, Ruilan, Wang, Ruiz Robledo, Aldana, Ruiz-Aguilar, Antonio Luis, Sadahiro, Tomohito, Saez, Ignacio, Sagardia, Judith, Saha, Rajnish, 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- 2023
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75. Changes in the Inferior Vena Cava Are More Sensitive Than Venous Pressure During Fluid Removal: A Proof-of-Concept Study
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Posada-Martinez, EDITH L., COX, ZACHARY L., CANO-NIETO, MARIANA M., IBARRA-MARQUEZ, NIKEIN D., MORENO-VILLAGOMEZ, JULIETA, GUDIÑO-BRAVO, PEDRO, ARIAS-GODINEZ, JOSE A., LOPEZ-GIL, SALVADOR, MADERO, MAGDALENA, RAO, VEENA S., MEBAZAA, ALEXANDRE, BURKHOFF, DANIEL, COWIE, MARTIN R., FUDIM, MARAT, DAMMAN, KEVIN, BORLAUG, BARRY A., TESTANI, JEFFREY M., and IVEY-MIRANDA, JUAN B.
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- 2023
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76. Impact of lockdown on cardiovascular disease hospitalizations in a Zero-COVID-19 country
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Moury, P.-H., Ochida, N., Motiejunaite, J., Collart, V., Série, M., Gervolino, S., Mangeas, M., Bouvier, J.-B., Couadau, E., Mebazaa, A., and Dupont-Rouzeyrol, M.
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- 2023
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77. Immunity and inflammation: the neglected key players in congenital heart disease?
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Wienecke, Laura M., Cohen, Sarah, Bauersachs, Johann, Mebazaa, Alexandre, and Chousterman, Benjamin G.
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- 2022
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78. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
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Marchal, A, Cirulli, E, Neveux, I, Bellos, E, Thwaites, R, Schiabor Barrett, K, Zhang, Y, Nemes-Bokun, I, Kalinova, M, Catchpole, A, Tangye, S, Spaan, A, Lack, J, Ghosn, J, Burdet, C, Gorochov, G, Tubach, F, Hausfater, P, Abel, L, Aiuti, A, Al-Muhsen, S, Al-Mulla, F, Amara, A, Anderson, M, Andreakos, E, Arias, A, Arkin, L, Feldman, H, Bastard, P, Belot, A, Biggs, C, Bogunovic, D, Bolze, A, Bondarenko, A, Borghesi, A, Bousfiha, A, Brodin, P, Bryceson, Y, Butte, M, Casanova, J, Casari, G, Christodoulou, J, Cobat, A, Colobran, R, Condino-Neto, A, Constantinescu, S, Cooper, M, Dalgard, C, Desai, M, Drolet, B, Duval, X, El Baghdadi, J, Eloy, P, Espinosa-Padilla, S, Fellay, J, Flores, C, Franco, J, Froidure, A, Gregersen, P, Grimbacher, B, Haerynck, F, Hagin, D, Halwani, R, Hammarstrom, L, Heath, J, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jouanguy, E, Kaja, E, Karamitros, T, Kisand, K, Ku, C, Lau, Y, Ling, Y, Lucas, C, Maniatis, T, Mansouri, D, Marodi, L, Mentre, F, Meyts, I, Milner, J, 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L. E., Montagne S., Richard L., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Kouakam C., Nicolas L., Roufai L., Amat K., Hendou S., Foti G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Bellani G., Abad J., Accordino G., Angelini M., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Darazam I. A., Roblero Albisures J. A., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Allende L. M., Alonso-Arias R., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Aytekin G., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Barzaghi F., Basso S., Bayhan G. 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P., Euvrard R., Fabio G., Faivre L., Falck A., Fartoukh M., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Cifuentes Godinez K. A., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Gut M., Hadjadj J., Hancerli S., Hariyan T., Hatipoglu N., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Kanik-Yuksek S., Kara Y., Karahan A., Karbuz A., Yasar K. K., Kasapcopur O., Kashimada K., Keles S., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Lopez R. L., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Adrian Bolanos Lima E. J., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Martin-Nalda A., Pueyo D. M., Martinez-Picado J., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Migeotte I., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Morange P. -E., Mordacq C., Morelle G., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Hubert Nielly, Medina Y. N., Cuadros E. N., Karabela S. N., Ocejo-Vinyals J. G., Oualha M., Ouedrani A., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Gonzalez Pellecer N. C., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Pineton de Chambrun M., Piralla A., Planas-Serra L., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., Rivet N., Riviere J. G., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., Ruiz del Prado M. Y., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schluter A., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Sobh A., Solanich X., Sole-Violan J., Soler C., Sozeri B., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorn K., Thumerelle C., Tipu I., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Troya J., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Tuter Oz S. K., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Zuniga Veliz S. P., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Van der Linden D., Volokha A., Vuotto F., Wauters E., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Young M. -A., Willis A., Lapuente-Suanzes P., de Andres-Martin A., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Chouchane O., Cloherty A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geerlings S., Geijtenbeek T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Hermans S. M., Heunks L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D. P., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Delmonte O. M., Danielson J. J., Biondi A., Bettini L. R., D'Angio M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Castagnoli R., Montagna D., Licari A., Marseglia G. L., Chiu C., and Grzymski J. J.
- Abstract
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
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- 2024
79. Trending Ability of End-Tidal Capnography Monitoring During Mechanical Ventilation to Track Changes in Arterial Partial Pressure of Carbon Dioxide in Critically Ill Patients With Acute Brain Injury: A Monocenter Retrospective Study
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Coëffic, Adrien, Joaquim, Jona, Manquat, Elsa, Felliot, Élodie, Vallée, Fabrice, Mebazaa, Alexandre, Gayat, Étienne, Chousterman, Benjamin Glenn, and Barthélémy, Romain
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- 2023
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80. Intraoperative Electroencephalography Alpha-Band Power Is a Better Proxy for Preoperative Low MoCA Under Propofol Compared With Sevoflurane
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Guessous, K., Touchard, C., Glezerson, B., Levé, C., Sabbagh, D., Mebazaa, A., Gayat, E., Paquet, C., Vallée, F., and Cartailler, J.
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- 2023
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81. Advances in the Management of Cardiogenic Shock
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Jentzer, Jacob C., Pöss, Janine, Schaubroeck, Hannah, Morrow, David A., Hollenberg, Steven M., and Mebazaa, Alexandre
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- 2023
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82. A universal predictive and mechanistic urinary peptide signature in acute kidney injury
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Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger, Kidney Attack Study Group, Julia Grossac, Harald Mischak, Alberto Ortiz, Stéphane Gazut, Joost P. Schanstra, Stanislas Faguer, Nicolas Mayeur, Audrey Casemayou, and François Labaste
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Acute kidney injury ,Cardiac surgery ,Intensive care unit ,Urinary peptidomics ,Prediction ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of specificity of current single AKI biomarkers hamper its management. Urinary peptidome analysis may help to identify early molecular changes in AKI and grasp its complexity to identify potential targetable molecular pathways. Methods In derivation and validation cohorts totalizing 1170 major cardiac bypass surgery patients and in an external cohort of 1569 intensive care unit (ICU) patients, a peptide-based score predictive of AKI (7-day KDIGO classification) was developed, validated, and compared to the reference biomarker urinary NGAL and NephroCheck and clinical scores. Results A set of 204 urinary peptides derived from 48 proteins related to hemolysis, inflammation, immune cells trafficking, innate immunity, and cell growth and survival was identified and validated for the early discrimination (
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- 2022
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83. Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors
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Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h, Imke Mayer, Malha Sadoune, Pierre-François Laterre, Romain Sonneville, Lorraine Ware, Alexandre Mebazaa, and Antoine Kimmoun
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Transfusion ,Mortality ,Critical care unit ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mortality. Methods FROG-ICU, a multicenter European study enrolling all-comers critical care patients was analyzed (n = 1551). Association between red blood cells transfusion administered in intensive care unit and 1-year mortality in critical care survivors was analyzed using an augmented inverse probability of treatment weighting-augmented inverse probability of censoring weighting method to control confounders. Results Among the 1551 ICU-survivors, 42% received at least one unit of red blood cells while in intensive care unit. Patients in the transfusion group had greater severity scores than those in the no-transfusion group. According to unweighted analysis, 1-year post-critical care mortality was greater in the transfusion group compared to the no-transfusion group (hazard ratio (HR) 1.78, 95% CI 1.45–2.16). Weighted analyses including 40 confounders, showed that transfusion remained associated with a higher risk of long-term mortality (HR 1.21, 95% CI 1.06–1.46). Conclusions Our results suggest a high incidence of in-ICU RBC transfusion and that in-ICU transfusion is associated with a higher 1-year mortality among in-ICU survivors. Trial registration ( NCT01367093 ; Registered 6 June 2011). Graphic Abstract
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- 2022
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84. A network meta-analysis of therapeutic and prophylactic management of vasospasm on aneurysmal subarachnoid hemorrhage outcomes
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Benjamin Chousterman, Brice Leclère, Louis Morisson, Yannick Eude, Etienne Gayat, Alexandre Mebazaa, and Raphael Cinotti
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subarachnoid hemorrhage ,network meta-analysis ,mortality ,outcome ,vasospasm ,delayed ischemic deficit ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundVasospasm and cerebral ischemia after aneurysmal subarachnoid hemorrhage are associated with mortality and poor neurological outcomes. We studied the efficacy of all available strategies targeting vasospasm and cerebral ischemia on outcomes in a network meta-analysis.MethodsWe searched EMBASE and MEDLINE databases from 1 January 1990 and 28 November 2021 according to PRISMA guidelines. Randomized controlled trials and longitudinal studies were included. All curative or preventive strategies targeting vasospasm and/or cerebral ischemia were eligible. A network meta-analysis was performed to compare all interventions with one another in a primary (randomized controlled trials only) and a secondary analysis (both trials and longitudinal studies). Mortality by 3 months was the primary outcome. Secondary outcomes were vasospasm, neurological outcome by 3 months, and dichotomized as “good” or “poor” recovery according to each study definition.ResultsA total of 2,382 studies were screened which resulted in the selection of 192 clinical trials (92 (47.9%) and 100 cohorts (52.1%) and the inclusion of 41,299 patients. In randomized controlled studies, no strategy decreased mortality by 3 months. Statins (0.79 [0.62–1]), tirilazad (0.82 [0.69–0.97]), CSF drainage (0.47 [0.29–0.77]), and clazosentan (0.51 [0.36–0.71]) significantly decreased the incidence of vasospasm. Cilostazol was the only treatment associated with improved neurological outcomes by 3 months in the primary (OR 1.16, 95% CI [1.05–1.28]) and secondary analyses (OR 2.97, 95% CI [1.39–6.32]).DiscussionIn the modern era of subarachnoid hemorrhage, all strategies targeting vasospasm failed to decrease mortality. Cilostazol should be confirmed as a treatment to improve neurological outcomes. The link between vasospasm and neurological outcome appears questionable.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=116073, identifier: PROSPERO CRD42018116073.
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- 2023
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85. The association of myocardial strain with cardiac magnetic resonance and clinical outcomes in patients with acute myocarditis
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Alexandre M. Soeiro, Aline S. Bossa, Maria C. César, Tatiana C. A. T. Leal, Guilherme Garcia, Rafael A. Fonseca, Débora Nakamura, Patrícia O. Guimarães, Maria C. F. A. Soeiro, Carlos V. Serrano, Paulo R. Soares, Christian Mueller, Alexandre Mebazaa, Fábio Fernandes, Cesar H. Nomura, Carlos E. Rochitte, and Múcio T. de Oliveira
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magnetic resoance imaging ,pericarditis ,myocarditis ,myocardial strain ,diagnosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
IntroductionThe role of myocardial strain in risk prediction for acute myocarditis (AMC) patients, measured by cardiac magnetic resonance (CMR), deserves further investigation. Our objective was to evaluate the association between myocardial strain measured by CMR and clinical events in AMC patients.Material and methodsThis was a prospective single-center study of patients with AMC. We included 100 patients with AMC with CMR confirmation. The primary outcome was the composite of all-cause mortality, heart failure and AMC recurrence in 24 months. A subgroup analysis was performed on a sample of 36 patients who underwent a second CMR between 6 and 18 months. The association between strain measures and clinical events or an increase in left ventricular ejection fraction (LVEF) was explored using Cox regression analysis. Global peak radial, circumferential and longitudinal strain in the left and right ventricles was assessed. ROC curve analysis was performed to identify cutoff points for clinical event prediction.ResultsThe mean follow-up was 18.7 ± 2.3 months, and the composite primary outcome occurred in 26 patients. The median LVEF at CMR at baseline was 57.5% (14.6%). LV radial strain (HR = 0.918, 95% CI: 0.858–0.982, p = 0.012), LV circumferential strain (HR = 1.177, 95% CI: 1.046–1.325, p = 0.007) and LV longitudinal strain (HR = 1.173, 95% CI: 1.031–1.334, p = 0.015) were independently associated with clinical event occurrence. The areas under the ROC curve for clinical event prediction were 0.80, 0.79 and 0.80 for LV radial, circumferential, and longitudinal strain, respectively. LV longitudinal strain was independently correlated with prognosis (HR = 1.282, CI 95%: 1.022–1.524, p = 0.007), even when analyzed together with ejection fraction and delayed enhancement. LV and right ventricle (RV) strain were not associated with an increase in LVEF. Finally, when the initial CMR findings were compared with the follow-up CMR findings, improvements in the measures of LV and RV myocardial strain were observed.ConclusionMeasurement of myocardial strain by CMR can provide prognostic information on AMC patients. LV radial, circumferential and longitudinal strain were associated with long-term clinical events in these patients.
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- 2023
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86. Activity of the adrenomedullin system to personalise post-discharge diuretic treatment in acute heart failure
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Kozhuharov, Nikola, Ng, Leong, Wussler, Desiree, Strebel, Ivo, Sabti, Zaid, Hartmann, Oliver, Eltayeb, Mohamed, Squire, Iain, Nowak, Albina, Rieger, Max, Martin, Jasmin, Michou, Eleni, Stefanelli, Sabrina, Puelacher, Christian, Shrestha, Samyut, Belkin, Maria, Zimmermann, Tobias, Lopez-Ayala, Pedro, Struck, Joachim, Bergmann, Andreas, Mebazaa, Alexandre, Blet, Alice, Gualandro, Danielle Menosi, Breidthardt, Tobias, and Mueller, Christian
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- 2022
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87. Soluble triggering receptor expressed on myeloid cells-1 is a marker of organ injuries in cardiogenic shock: results from the CardShock Study
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Kimmoun, Antoine, Duarte, Kevin, Harjola, Veli-Pekka, Tarvasmäki, Tuukka, Levy, Bruno, Mebazaa, Alexandre, and Gibot, Sebastien
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- 2022
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88. Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial
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Mebazaa, Alexandre, Davison, Beth, Chioncel, Ovidiu, Cohen-Solal, Alain, Diaz, Rafael, Filippatos, Gerasimos, Metra, Marco, Ponikowski, Piotr, Sliwa, Karen, Voors, Adriaan A, Edwards, Christopher, Novosadova, Maria, Takagi, Koji, Damasceno, Albertino, Saidu, Hadiza, Gayat, Etienne, Pang, Peter S, Celutkiene, Jelena, and Cotter, Gad
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- 2022
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89. The Intersection Between Heart Failure and Critical Care Cardiology: An International Perspective on Structure, Staffing, and Design Considerations
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Sinha, SHASHANK S., BOHULA, ERIN A., DIEPEN, SEAN VAN, LEONARDI, SERGIO, Mebazaa, Alexandre, Proudfoot, Alastair G., SIONIS, ALESSANDRO, CHIA, YEW WOON, ZAMPIERI, FERNANDO G., LOPES, RENATO D., and KATZ, JASON N.
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- 2022
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90. Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway.
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Prud'homme, Mathilde, Coutrot, Maxime, Michel, Thibault, Boutin, Louis, Genest, Magali, Poirier, Françoise, Launay, Jean-Marie, Kane, Bocar, Kinugasa, Satoshi, Prakoura, Niki, Vandermeersch, Sophie, Cohen-Solal, Alain, Delcayre, Claude, Samuel, Jane-Lise, Mehta, Ravindra, Gayat, Etienne, Mebazaa, Alexandre, Chadjichristos, Christos E, and Legrand, Matthieu
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AKI ,acute kidney injury ,BM ,bone marrow ,BUN ,blood urea nitrogen ,Cr ,creatinine ,Gal-3 ,galectin-3 ,ICAM ,intercellular adhesion molecule ,ICU ,intensive care unit ,IL ,interleukin ,IR ,ischemia-reperfusion ,KDIGO ,Kidney Disease Improving Global Outcome ,KO ,knock-out ,MCP ,modified citrus pectin ,NT-proBNP ,N-terminal-pro-brain natriuretic peptide ,TGF ,transforming growth factor ,TNF ,tumor necrosis factor ,UUO ,unilateral ureteral obstruction ,WT ,wild type ,eGFR ,estimated glomerular filtration rate ,fibrosis ,heart failure ,inflammation ,macrophages ,renal failure ,AKI ,acute kidney injury ,BM ,bone marrow ,BUN ,blood urea nitrogen ,Cr ,creatinine ,Gal-3 ,galectin-3 ,ICAM ,intercellular adhesion molecule ,ICU ,intensive care unit ,IL ,interleukin ,IR ,ischemia-reperfusion ,KDIGO ,Kidney Disease Improving Global Outcome ,KO ,knock-out ,MCP ,modified citrus pectin ,NT-proBNP ,N-terminal-pro-brain natriuretic peptide ,TGF ,transforming growth factor ,TNF ,tumor necrosis factor ,UUO ,unilateral ureteral obstruction ,WT ,wild type ,eGFR ,estimated glomerular filtration rate ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences - Abstract
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.
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- 2019
91. Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
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Prud’homme, Mathilde, Coutrot, Maxime, Michel, Thibault, Boutin, Louis, Genest, Magali, Poirier, Françoise, Launay, Jean-Marie, Kane, Bocar, Kinugasa, Satoshi, Prakoura, Niki, Vandermeersch, Sophie, Cohen-Solal, Alain, Delcayre, Claude, Samuel, Jane-Lise, Mehta, Ravindra, Gayat, Etienne, Mebazaa, Alexandre, Chadjichristos, Christos E, and Legrand, Matthieu
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Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Prevention ,Cardiovascular ,Heart Disease ,Aetiology ,2.1 Biological and endogenous factors ,Renal and urogenital ,Good Health and Well Being ,fibrosis ,heart failure ,inflammation ,macrophages ,renal failure ,AKI ,acute kidney injury ,BM ,bone marrow ,BUN ,blood urea nitrogen ,Cr ,creatinine ,Gal-3 ,galectin-3 ,ICAM ,intercellular adhesion molecule ,ICU ,intensive care unit ,IL ,interleukin ,IR ,ischemia-reperfusion ,KDIGO ,Kidney Disease Improving Global Outcome ,KO ,knock-out ,MCP ,modified citrus pectin ,NT-proBNP ,N-terminal-pro-brain natriuretic peptide ,TGF ,transforming growth factor ,TNF ,tumor necrosis factor ,UUO ,unilateral ureteral obstruction ,WT ,wild type ,eGFR ,estimated glomerular filtration rate ,Cardiorespiratory Medicine and Haematology ,Cardiovascular medicine and haematology - Abstract
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.
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- 2019
92. Effect of systemic corticosteroid therapy for acute heart failure patients with elevated C‐reactive protein
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Òscar Miró, Koji Takagi, Beth A. Davison, Christopher Edwards, Yonathan Freund, Javier Jacob, Pere Llorens, Alexandre Mebazaa, and Gad Cotter
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Acute heart failure ,Inflammation ,Corticosteroids ,Emergency department ,Mortality ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims The current study explores whether degree of inflammation, reflected by C‐reactive protein (CRP) level, modifies the effect of intravenous (IV) corticosteroid administered in the emergency department (ED) on clinical outcomes in patients with acute heart failure (AHF). Methods and results We selected patients diagnosed with AHF in the ED, with confirmed N‐terminal pro‐B‐type natriuretic peptide > 300 pg/mL and CRP > 5 mg/L in the ED from the Epidemiology of Acute Heart Failure in the Emergency Departments (EAHFE) registry. In these 1109 patients, 121 were treated by corticosteroid. The corticosteroid therapy hazard ratio (HR) for 30 day all‐cause mortality was 1.26 [95% confidence interval (CI) 0.75–2.09, P = 0.38]. Although not statistically significant, HRs tended to decrease with increasing CRP level, with point estimates favouring corticosteroid at CRP levels above 20. In patients with CRP > 40 mg/L, with adjusted HRs of 0.56 (95% CI 0.20–1.55, P = 0.27) for 30 day all‐cause mortality, 0.92 (95% CI 0.52–1.62, P = 0.78) for 30 day post‐discharge ED revisit, hospitalization, or death, and adjusted odds ratio of 0.61 (95% CI 0.17–2.14, P = 0.44) for in‐hospital all‐cause mortality. Conclusions The present analysis suggests that corticosteroids might have the potential to improve outcomes in AHF patients with inflammatory activation. Larger, prospective studies of anti‐inflammatory therapy should be considered to assess potential benefit in patients with the highest degree of inflammation.
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- 2022
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93. Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.
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Mebazaa, Alexandre, Geven, Christopher, Hollinger, Alexa, Wittebole, Xavier, Chousterman, Benjamin Glen, Blet, Alice, Gayat, Etienne, Hartmann, Oliver, Scigalla, Paul, Struck, Joachim, Bergmann, Andreas, Antonelli, Massimo, Beishuizen, Albertus, Constantin, Jean-Michel, Damoisel, Charles, Deye, Nicolas, Di Somma, Salvatore, Dugernier, Thierry, François, Bruno, Gaudry, Stephane, Huberlant, Vincent, Lascarrou, Jean-Baptiste, Marx, Gernot, Mercier, Emmanuelle, Oueslati, Haikel, Pickkers, Peter, Sonneville, Romain, Legrand, Matthieu, Laterre, Pierre-François, and AdrenOSS-1 study investigators
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AdrenOSS-1 study investigators ,Humans ,Sepsis ,Multiple Organ Failure ,Hospitalization ,Length of Stay ,Hospital Mortality ,Proportional Hazards Models ,Chi-Square Distribution ,Survival Analysis ,Prospective Studies ,Aged ,Middle Aged ,Intensive Care Units ,Belgium ,France ,Germany ,Italy ,Netherlands ,Female ,Male ,Adrenomedullin ,Patient Outcome Assessment ,Biomarkers ,Biomarker ,Outcome ,Sepsis-2 ,Sepsis-3 ,Emergency & Critical Care Medicine ,Medical and Health Sciences - Abstract
BackgroundAdrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.MethodsAdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock.ResultsCirculating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8).ConclusionsAdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial.Trial registrationClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.
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- 2018
94. Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study
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Gayat, Etienne, Cariou, Alain, Deye, Nicolas, Vieillard-Baron, Antoine, Jaber, Samir, Damoisel, Charles, Lu, Qin, Monnet, Xavier, Rennuit, Isabelle, Azoulay, Elie, Léone, Marc, Oueslati, Heikel, Guidet, Bertrand, Friedman, Diane, Tesnière, Antoine, Sonneville, Romain, Montravers, Philippe, Pili-Floury, Sébastien, Lefrant, Jean-Yves, Duranteau, Jacques, Laterre, Pierre-François, Brechot, Nicolas, Chevreul, Karine, Michel, Morgane, Cholley, Bernard, Legrand, Matthieu, Launay, Jean-Marie, Vicaut, Eric, Singer, Mervyn, Resche-Rigon, Matthieu, and Mebazaa, Alexandre
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Patient Safety ,Cardiovascular ,Heart Disease ,Good Health and Well Being ,Aged ,Belgium ,Cohort Studies ,Critical Illness ,Female ,France ,Hospital Mortality ,Hospitalization ,Humans ,Intensive Care Units ,Length of Stay ,Male ,Middle Aged ,Odds Ratio ,Outcome Assessment ,Health Care ,Prospective Studies ,Respiration ,Artificial ,Survivors ,Time Factors ,Vasoconstrictor Agents ,Biomarkers ,Discharge ,Long-term survival ,Post-intensive care syndrome ,Score ,Medical and Health Sciences ,Emergency & Critical Care Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundIntensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was to identify clinical and biological determinants of death in the year following ICU discharge.MethodsFROG-ICU was a prospective, observational, multicenter cohort study of ICU survivors followed 1 year after discharge, including 21 medical, surgical or mixed ICUs in France and Belgium. All consecutive patients admitted to intensive care with a requirement for invasive mechanical ventilation and/or vasoactive drug support for more than 24 h following ICU admission and discharged from ICU were included. The main outcome measure was all-cause mortality at 1 year after ICU discharge. Clinical and biological parameters on ICU discharge were measured, including the circulating cardiovascular biomarkers N-terminal pro-B type natriuretic peptide, high-sensitive troponin I, bioactive-adrenomedullin and soluble-ST2. Socioeconomic status was assessed using a validated deprivation index (FDep).ResultsOf 1570 patients discharged alive from the ICU, 333 (21%) died over the following year. Multivariable analysis identified age, comorbidity, red blood cell transfusion, ICU length of stay and abnormalities in common clinical factors at the time of ICU discharge (low systolic blood pressure, temperature, total protein, platelet and white cell count) as independent factors associated with 1-year mortality. Elevated biomarkers of cardiac and vascular failure independently associated with 1-year death when they are added to multivariable model, with an almost 3-fold increase in the risk of death when combined (adjusted odds ratio 2.84 (95% confidence interval 1.73-4.65), p
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- 2018
95. Machine Learning Approaches for Phenotyping in Cardiogenic Shock and Critical Illness: Part 2 of 2
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Jentzer, Jacob C., Rayfield, Corbin, Soussi, Sabri, Berg, David D., Kennedy, Jason N., Sinha, Shashank S., Baran, David A., Brant, Emily, Mebazaa, Alexandre, Billia, Filio, Kapur, Navin K., Henry, Timothy D., and Lawler, Patrick R.
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- 2022
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96. Advances in the Staging and Phenotyping of Cardiogenic Shock: Part 1 of 2
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Jentzer, Jacob C., Rayfield, Corbin, Soussi, Sabri, Berg, David D., Kennedy, Jason N., Sinha, Shashank S., Baran, David A., Brant, Emily, Mebazaa, Alexandre, Billia, Filio, Kapur, Navin K., Henry, Timothy D., and Lawler, Patrick R.
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- 2022
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97. Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study
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Staessen, Jan A, Wendt, Ralph, Yu, Yu-Ling, Kalbitz, Sven, Thijs, Lutgarde, Siwy, Justyna, Raad, Julia, Metzger, Jochen, Neuhaus, Barbara, Papkalla, Armin, von der Leyen, Heiko, Mebazaa, Alexandre, Dudoignon, Emmanuel, Spasovski, Goce, Milenkova, Mimoza, Canevska-Taneska, Aleksandra, Lazo, Mercedes Salgueira, Psichogiou, Mina, Rajzer, Marek W, Fulawka, Lukasz, Dzitkowska-Zabielska, Magdalena, Weiss, Guenter, Feldt, Torsten, Stegemann, Miriam, Normark, Johan, Zoufaly, Alexander, Schmiedel, Stefan, Seilmaier, Michael, Rumpf, Benedikt, Banasik, Mirosław, Krajewska, Magdalena, Catanese, Lorenzo, Rupprecht, Harald, Czerwienska, Beata, Peters, Björn, Nilsson, Åsa, Rothfuss, Katja, Lübbert, Christoph, Mischak, Harald, Beige, Joachim, Ermisch, Jörg, Kellner, Nils, Peruth-Stutzmann, Lydia, Schroth, Stefanie, Schmidt, Jonathan, Schmidt, Ulrike, Breuer, Daniel, Abeud, Fariza, Fournier, Marie-Celine, Louadah, Badr, Molas, Rocio, Rojas, Fraile Loreto, García, Fabiola Alonso, Sánchez, Isabel Garcia, Hrom, Ioana Cezara, Więczek., Andrzej, Schwab, Matthias, K Asayama, Kei, Hansen, Tine W, Maestre, Gladys E, Basoulis, Dimitrios, Karamanakos., Georgios, Lis, Pawel, Olszanecka, Agnieszka, Bellmann-Weiler, Rosa, Lanser, Lucas, Edin, Alicia, Forsell, Matthias NE, Stegmayr, Bernd, Jensen, Björn-Erik Ole, Orth, Hans-Martin, Borstel, Sylke, Mikolajewska, Agata, Hecking, Manfred, Schmölz, Lukas, Hoffmann, Michał, Narkiewicz, Krzysztof, Matera-Witkiewicz, Agnieszka, Zachciał, Justyna, Litwin, Monika, Marciniak, Patrycja, Salgueira Lazo, Mercedes, Fuławka, Łukasz, Rupprecht, Harald D, and Czerwieńska, Beata
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- 2022
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98. Opportunities for improved clinical trial designs in acute respiratory distress syndrome
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Wick, Katherine D, Aggarwal, Neil R, Curley, Martha A Q, Fowler, Alpha A, III, Jaber, Samir, Kostrubiec, Maciej, Lassau, Nathalie, Laterre, Pierre François, Lebreton, Guillaume, Levitt, Joseph E, Mebazaa, Alexandre, Rubin, Eileen, Sinha, Pratik, Ware, Lorraine B, and Matthay, Michael A
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- 2022
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99. Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19
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Casey, Jonathan D, Beskow, Laura M, Brown, Jeremy, Brown, Samuel M, Gayat, Étienne, Ng Gong, Michelle, Harhay, Michael O, Jaber, Samir, Jentzer, Jacob C, Laterre, Pierre-François, Marshall, John C, Matthay, Michael A, Rice, Todd W, Rosenberg, Yves, Turnbull, Alison E, Ware, Lorraine B, Self, Wesley H, Mebazaa, Alexandre, and Collins, Sean P
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- 2022
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100. Biologically Active Adrenomedullin (bio-ADM) is of Potential Value in Identifying Congestion and Selecting Patients for Neurohormonal Blockade in Acute Dyspnea
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Simonavičius, Justas, Mikalauskas, Aurimas, Čerlinskaitė, Kamilė, Gayat, Etienne, Juknevičius, Vytautas, Palevičiūtė, Eglė, Alitoit-Marrote, Irina, Kablučko, Denis, Bagdonaitė, Loreta, Balčiūnas, Mindaugas, Vaičiulienė, Dovilė, Jonauskienė, Ieva, Motiejūnaitė, Justina, Stašaitis, Kęstutis, Kukulskis, Audrys, Damalakas, Šarūnas, Šimbelytė, Toma, Taparauskaitė, Neringa, Pukanasienė, Gintarė, Laucevičius, Aleksandras, Kavoliūnienė, Aušra, Mebazaa, Alexandre, and Čelutkienė, Jelena
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- 2022
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