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52. Eating habits of young children with Down syndrome in the Netherlands: adequate nutrient intakes but delayed introduction of solid food

Author

Hopman, Erica, Csizmadia, Cassandra G., Bastiani, Wieke F., Engels, Quirina M., De Graaf, Erik A., Le Cessie, Saskia, and Mearin, M. Luisa

Subjects
Nutrition -- Research, Children -- Food and nutrition, Food habits -- Research, Food/cooking/nutrition, Research, Food and nutrition
Abstract

Objectives To investigate nutritional status, pattern of being breast-fed, age at introduction of solid food, and adequacy of energy and nutrient intakes in children with Down syndrome in The Netherlands. Design Nutritional status was assessed by height and weight measurements. The dietary history method was used to collect information on the diet. Data obtained from children with Down syndrome were compared with data from control subjects and from the general population of Dutch children. Adequacy of energy and nutrient intakes was assessed by comparison to US recommendations. Subjects Forty-four Dutch children with Down syndrome (newborns to 4-year-olds) and 37 healthy control subjects without this syndrome. Statistical analyses The prevalence of breast-feeding of children with and without Down syndrome was compared using the [Χ.sup.2] test. To compare ages at which solid food was introduced, the log-rank test and Kaplan-Meier curves were used. Anthropometric data and mean dietary intake were compared between the groups using 2-way analysis of variance. Comparison to recommended levels of dietary intake was performed using 95% confidence intervals. Results Heights and weights of the children with Down syndrome were in the normal range. Down syndrome does not affect the prevalence of breast-feeding of children or the adequacy of their energy and nutrient intakes, but it does significantly delay the age at which solid food is introduced, which can be deleterious to oral-motor development. Application If late introduction of solid food is observed in children with Down syndrome, pre-speech therapy should be considered., Feeding problems in children with developmental disabilities can predispose them to low energy and nutrient intake (1). Although studies have reported different serum levels of vitamins and minerals in children [...]

Published
1998

53. Raising the Cut-Off Level of Anti-Tissue Transglutaminase Antibodies to Detect Celiac Disease Reduces the Number of Small Bowel Biopsies in Children with Type 1 Diabetes: A Retrospective Study

Author

MDL, Child Health, Wessels, Margreet, Velthuis, Anouk, van Lochem, Ellen, Duijndam, Eline, Hoorweg-Nijman, Gera, de Kruijff, Ineke, Wolters, Victorien, Berghout, Eveline, Meijer, Jos, Bokma, Jan Alle, Mul, Dick, van der Velden, Janielle, Roovers, Lian, Mearin, M Luisa, van Setten, Petra, MDL, Child Health, Wessels, Margreet, Velthuis, Anouk, van Lochem, Ellen, Duijndam, Eline, Hoorweg-Nijman, Gera, de Kruijff, Ineke, Wolters, Victorien, Berghout, Eveline, Meijer, Jos, Bokma, Jan Alle, Mul, Dick, van der Velden, Janielle, Roovers, Lian, Mearin, M Luisa, and van Setten, Petra

Published
2020

56. Longitudinal Variation of Amino Acid Levels in Human Milk and Their Associations with Infant Gender

Author

van Sadelhoff, Joris H J, van de Heijning, Bert J M, Stahl, Bernd, Amodio, Sonia, Rings, Edmond H H M, Mearin, M Luisa, Garssen, Johan, Hartog, Anita, Afd Pharmacology, Pharmacology, Pediatrics, Afd Pharmacology, and Pharmacology

Subjects
0301 basic medicine, Male, breastfeeding, Breastfeeding, Physiology, Amino Acids/analysis, free amino acids, Lactation, Human/chemistry, Longitudinal Studies, Amino Acids, Glutamine/analysis, Netherlands, chemistry.chemical_classification, Nutrition and Dietetics, Postpartum Period, Gender Identity, Milk Proteins, Early life, Amino acid, Milk, medicine.anatomical_structure, Breast Feeding, glutamine, Female, lcsh:Nutrition. Foods and food supply, Adult, Mothers, lcsh:TX341-641, glutamate, Biology, Article, 03 medical and health sciences, Sex Factors, medicine, Humans, 030109 nutrition & dietetics, Milk, Human, Lactation/metabolism, Infant, Newborn, Infant, Milk, Human/chemistry, Small sample, Newborn, Glutamine, chemistry, Milk Proteins/analysis, Breast feeding, Postpartum period, Food Science
Abstract

It is discussed that specific amino acids (AAs) have functional roles in early life. Understanding the AA composition in human milk (HM) during lactation assists in specifying these roles. To this end we assessed the levels of free AAs (FAAs), total AAs (free and bound, TAAs) and protein levels in HM in the first 6 months of lactation, and evaluated possible associations with infant gender. HM samples of 25 healthy Dutch mothers participating in the PreventCD study were collected monthly during the first 6 months of lactation. Of the participating mothers, 12 gave birth to a boy and 13 gave birth to a girl. Analyses of the HM samples revealed that levels of free glutamate, glutamine, aspartate, glycine, and serine significantly increased during months 1&ndash, 3 of lactation, both in absolute sense and relative to TAA levels. Evaluation of gender differences by mixed model analyses revealed an association between female infant gender and higher protein content (p = 0.0465) and TAA content (p = 0.0362) in HM during the first 3 months of lactation. Furthermore, there was a tendency for an association of male infant gender with higher levels of free glutamine (p = 0.0948) in HM during the first 3 months of lactation. These results show that FAA, TAA and protein levels in HM display a time-specific occurrence during lactation. Moreover, although confirmation is necessary in view of the small sample size, this study indicates that the AA composition in HM shows differential effects of the infant&rsquo, s sex.

Published
2018
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57. The impact of human breast milk components on the infant metabolism

Author

Hellmuth, Christian, primary, Uhl, Olaf, additional, Demmelmair, Hans, additional, Grunewald, Maria, additional, Auricchio, Renata, additional, Castillejo, Gemma, additional, Korponay-Szabo, Ilma R., additional, Polanco, Isabel, additional, Roca, María, additional, Vriezinga, Sabine L., additional, Werkstetter, Katharina J., additional, Koletzko, Berthold, additional, Mearin, M. Luisa, additional, and Kirchberg, Franca F., additional

Published
2018
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58. Longitudinal Variation of Amino Acid Levels in Human Milk and Their Associations with Infant Gender

Author

Afd Pharmacology, Pharmacology, van Sadelhoff, Joris H J, van de Heijning, Bert J M, Stahl, Bernd, Amodio, Sonia, Rings, Edmond H H M, Mearin, M Luisa, Garssen, Johan, Hartog, Anita, Afd Pharmacology, Pharmacology, van Sadelhoff, Joris H J, van de Heijning, Bert J M, Stahl, Bernd, Amodio, Sonia, Rings, Edmond H H M, Mearin, M Luisa, Garssen, Johan, and Hartog, Anita

Published
2018

60. Pediatric IBD-unclassified Is Less Common than Previously Reported; Results of an 8-Year Audit of the EUROKIDS Registry

Author

Dwight A., Winter, Karolewska-Bochenek, Katarzyna, Lazowska-Przeorek, Izabella, Lionetti, Paolo, Mearin, M. Luisa, Chong, Sonny K., Roma-Giannikou, Eleftheria, Maly, Jan, Kolho, Kaija-Leena, Shaoul, Ron, Staiano, Annamaria, Damen, Gerard M., de Meij, Tim, Hendriks, Danielle, George, Elvira K., Turner, Dan, Escher, Johanna C., The Paediatric IBD Porto group of ESPGHAN, Sładek, Małgorzata, Pediatric surgery, CCA - Innovative therapy, Pediatrics, Dwight A., Winter, Katarzyna Karolewska, Bochenek, Izabella Lazowska, Przeorek, Paolo, Lionetti, M., Luisa Mearin, Sonny K., Chong, Eleftheria Roma, Giannikou, Jan, Maly, Kaija Leena, Kolho, Ron, Shaoul, Staiano, Annamaria, Gerard M., Damen, Tim de, Meij, Daniëlle, Hendrik, Elvira K., George, Dan, Turner, Johanna C., Escher, Growth and Development, and Clinical sciences

Subjects
Male, Pancolitis, Pediatrics, medicine.medical_specialty, Adolescent, diagnosis, Audit, Disease, Endoscopy, Gastrointestinal, Interquartile range, Intestine, Small, IBD-unclassified, medicine, Immunology and Allergy, Humans, Eurokids registry, Registries, Diagnostic Errors, Israel, Child, Retrospective Studies, Medical Audit, Adolescent onset, medicine.diagnostic_test, business.industry, Gastroenterology, Retrospective cohort study, medicine.disease, Inflammatory Bowel Diseases, Ulcerative colitis, digestive system diseases, Endoscopy, childhood and adolescence, Europe, Radiography, Porto criteria, Female, medicine.symptom, business, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Abstract

Background: Inflammatory bowel disease-unclassified (IBD-U) is diagnosed in ∼10% of pediatric and adolescent onset IBD patients. The EUROKIDS registry (2004) initiated by the Porto IBD working group of ESPGHAN prospectively monitors diagnostic workup of newly diagnosed pediatric and adolescent onset IBD patients. We aimed to describe diagnostic workup, phenotype, and change of diagnosis over time in pediatric IBD-U patients. Methods: Data were collected on children from 52 centers across 20 European countries and Israel, diagnosed with IBD from May 2005 through November 2013. Full endoscopy plus small bowel radiology was considered complete diagnostic workup. Participating centers reporting IBD-U patients were queried in 2014 for follow-up data. Results: IBD-U was the provisional first diagnosis in 265 of 3461 children (7.7%) (91/158 [58%] with pancolitis; 140 [53%] male), diagnosed more frequently under the age of 10 (median age 12.3 years, 89 [34%] under 10 years). Half (48%) had undergone complete diagnostic workup. Lack of small bowel radiology was the prevailing reason for incomplete workup. As a result of reinvestigations (endoscopy in 54%, radiology in 38%) during a median follow-up of 5.7 years (interquartile range, 2.5-7.8), a change in diagnosis from IBD-U to Crohn's disease (12%) or ulcerative colitis (20%) was reported. Conclusions: Only half of patients reported as IBD-U in EUROKIDS had undergone complete diagnostic workup. Follow-up with reinvestigations resulted in a reduction of IBD-U rate to 5.6%. A diagnosis of IBD-U becomes less likely in case of complete diagnostic workup. Implementation of clear diagnostic criteria will further reduce the rate of IBD-U in the future. © 2015 Crohn's & Colitis Foundation of America, Inc.

Published
2015
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61. Transition from childhood to adulthood in coeliac disease: the Prague consensus report

Author

Ludvigsson, Jonas F, primary, Agreus, Lars, additional, Ciacci, Carolina, additional, Crowe, Sheila E, additional, Geller, Marilyn G, additional, Green, Peter H R, additional, Hill, Ivor, additional, Hungin, A Pali, additional, Koletzko, Sibylle, additional, Koltai, Tunde, additional, Lundin, Knut E A, additional, Mearin, M Luisa, additional, Murray, Joseph A, additional, Reilly, Norelle, additional, Walker, Marjorie M, additional, Sanders, David S, additional, Shamir, Raanan, additional, Troncone, Riccardo, additional, and Husby, Steffen, additional

Published
2016
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62. Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR

Author

van Lummel, Menno, primary, van Veelen, Peter A., additional, de Ru, Arnoud H., additional, Janssen, George M. C., additional, Pool, Jos, additional, Laban, Sandra, additional, Joosten, Antoinette M., additional, Nikolic, Tatjana, additional, Drijfhout, Jan W., additional, Mearin, M. Luisa, additional, Aanstoot, Henk J., additional, Peakman, Mark, additional, and Roep, Bart O., additional

Published
2016
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64. Pediatric IBD-unclassified Is Less Common than Previously Reported; Results of an 8-Year Audit of the EUROKIDS Registry

Author

Winter, Dwight A., primary, Karolewska-Bochenek, Katarzyna, additional, Lazowska-Przeorek, Izabella, additional, Lionetti, Paolo, additional, Mearin, M. Luisa, additional, Chong, Sonny K., additional, Roma-Giannikou, Eleftheria, additional, Maly, Jan, additional, Kolho, Kaija-Leena, additional, Shaoul, Ron, additional, Staiano, Annamaria, additional, Damen, Gerard M., additional, de Meij, Tim, additional, Hendriks, Daniëlle, additional, George, Elvira K., additional, Turner, Dan, additional, and Escher, Johanna C., additional

Published
2015
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66. The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease

Author

Schmitz, Frederike, primary, Kooy-Winkelaar, Yvonne, additional, Wiekmeijer, Anna-Sophia, additional, Brugman, Martijn H, additional, Mearin, M Luisa, additional, Mulder, Chris, additional, Chuva de Sousa Lopes, Susana, additional, Mummery, Christine L, additional, Staal, Frank JT, additional, van Bergen, Jeroen, additional, and Koning, Frits, additional

Published
2015
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70. The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.

Author

Schmitz, Frederike, Kooy-Winkelaar, Yvonne, Wiekmeijer, Anna-Sophia, Brugman, Martijn H., Mearin, M. Luisa, Mulder, Chris, de Sousa Lopes, Susana Chuva, Mummery, Christine L., Staal, Frank J. T., van Bergen, Jeroen, and Koning, Frits

Subjects
DUODENAL diseases, LYMPHOCYTES, CELIAC disease, T cells, PHENOTYPES, HIERARCHICAL clustering (Cluster analysis), KILLER cells, CD antigens
Published
2016
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72. Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease : a biopsy-proven European multicentre study.

Author

Collin, Pekka, Kaukinen, Katri, Vogelsang, Harald, Korponay-Szabó, Ilma, Sommer, Rudolf, Schreier, Elisabeth, Volta, Umberto, Granito, Alessandro, Veronesi, Lorenza, Mascart, Françoise, Ocmant, Annick, Ivarsson, Anneli, Lagerqvist, Carina, Bürgin-Wolff, Annemarie, Hadziselimovic, Faruk, Furlano, Raoul I, Sidler, Marc A, Mulder, Chris J J, Goerres, Marije S, Mearin, M Luisa, Ninaber, Maarten K, Gudmand-Høyer, Eivind, Fabiani, Elisabetta, Catassi, Carlo, Tidlund, Helena, Alainentalo, Lisbeth, Mäki, Markku, Collin, Pekka, Kaukinen, Katri, Vogelsang, Harald, Korponay-Szabó, Ilma, Sommer, Rudolf, Schreier, Elisabeth, Volta, Umberto, Granito, Alessandro, Veronesi, Lorenza, Mascart, Françoise, Ocmant, Annick, Ivarsson, Anneli, Lagerqvist, Carina, Bürgin-Wolff, Annemarie, Hadziselimovic, Faruk, Furlano, Raoul I, Sidler, Marc A, Mulder, Chris J J, Goerres, Marije S, Mearin, M Luisa, Ninaber, Maarten K, Gudmand-Høyer, Eivind, Fabiani, Elisabetta, Catassi, Carlo, Tidlund, Helena, Alainentalo, Lisbeth, and Mäki, Markku

Published
2005

74. Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II

Author

Schmitz, Frederike, primary, Tjon, Jennifer M L, additional, Lai, Yuching, additional, Thompson, Allan, additional, Kooy-Winkelaar, Yvonne, additional, Lemmers, Richard J L F, additional, Verspaget, Hein W, additional, Mearin, M Luisa, additional, Staal, Frank J, additional, Schreurs, Marco W, additional, Cupedo, Tom, additional, Langerak, Anton W, additional, Mulder, Chris J, additional, van Bergen, Jeroen, additional, and Koning, Frits, additional

Published
2012
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78. Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet

Author

Esch, Caroline E. Hogen, primary, Wolters, Victorien M., additional, Gerritsen, Susan A. M., additional, Putter, Hein, additional, von Blomberg, B. Mary, additional, van Hoogstraten, Ingrid M. W., additional, Houwen, Roderick H. J., additional, van der Lely, Nico, additional, and Mearin, M. Luisa, additional

Published
2011
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79. Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations

Author

Einarsdottir, Elisabet, primary, Bevova, Marianna R, additional, Zhernakova, Alexandra, additional, Monsuur, Alienke, additional, Koskinen, Lotta LE, additional, Slot, Ruben van't, additional, Mulder, Chris, additional, Mearin, M Luisa, additional, Korponay-Szabo, Ilma R, additional, Kaukinen, Katri, additional, Kurppa, Kalle, additional, Kere, Juha, additional, Mäki, Markku, additional, Wijmenga, Cisca, additional, and Saavalainen, Päivi, additional

Published
2011
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80. Erratum: Corrigendum: Multiple common variants for celiac disease influencing immune gene expression

Author

Dubois, Patrick C A, primary, Trynka, Gosia, additional, Franke, Lude, additional, Hunt, Karen A, additional, Romanos, Jihane, additional, Curtotti, Alessandra, additional, Zhernakova, Alexandra, additional, Heap, Graham A R, additional, Ádány, Róza, additional, Aromaa, Arpo, additional, Bardella, Maria Teresa, additional, van den Berg, Leonard H, additional, Bockett, Nicholas A, additional, de la Concha, Emilio G, additional, Dema, Bárbara, additional, Fehrmann, Rudolf S N, additional, Fernández-Arquero, Miguel, additional, Fiatal, Szilvia, additional, Grandone, Elvira, additional, Green, Peter M, additional, Groen, Harry J M, additional, Gwilliam, Rhian, additional, Houwen, Roderick H J, additional, Hunt, Sarah E, additional, Kaukinen, Katri, additional, Kelleher, Dermot, additional, Korponay-Szabo, Ilma, additional, Kurppa, Kalle, additional, MacMathuna, Padraic, additional, Mäki, Markku, additional, Mazzilli, Maria Cristina, additional, McCann, Owen T, additional, Mearin, M Luisa, additional, Mein, Charles A, additional, Mirza, Muddassar M, additional, Mistry, Vanisha, additional, Mora, Barbara, additional, Morley, Katherine I, additional, Mulder, Chris J, additional, Murray, Joseph A, additional, Núñez, Concepción, additional, Oosterom, Elvira, additional, Ophoff, Roel A, additional, Polanco, Isabel, additional, Peltonen, Leena, additional, Platteel, Mathieu, additional, Rybak, Anna, additional, Salomaa, Veikko, additional, Schweizer, Joachim J, additional, Sperandeo, Maria Pia, additional, Tack, Greetje J, additional, Turner, Graham, additional, Veldink, Jan H, additional, Verbeek, Wieke H M, additional, Weersma, Rinse K, additional, Wolters, Victorien M, additional, Urcelay, Elena, additional, Cukrowska, Bozena, additional, Greco, Luigi, additional, Neuhausen, Susan L, additional, McManus, Ross, additional, Barisani, Donatella, additional, Deloukas, Panos, additional, Barrett, Jeffrey C, additional, Saavalainen, Paivi, additional, Wijmenga, Cisca, additional, and van Heel, David A, additional

Published
2010
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83. Newly identified genetic risk variants for celiac disease related to the immune response

Author

Hunt, Karen A, primary, Zhernakova, Alexandra, additional, Turner, Graham, additional, Heap, Graham A R, additional, Franke, Lude, additional, Bruinenberg, Marcel, additional, Romanos, Jihane, additional, Dinesen, Lotte C, additional, Ryan, Anthony W, additional, Panesar, Davinder, additional, Gwilliam, Rhian, additional, Takeuchi, Fumihiko, additional, McLaren, William M, additional, Holmes, Geoffrey K T, additional, Howdle, Peter D, additional, Walters, Julian R F, additional, Sanders, David S, additional, Playford, Raymond J, additional, Trynka, Gosia, additional, Mulder, Chris J J, additional, Mearin, M Luisa, additional, Verbeek, Wieke H M, additional, Trimble, Valerie, additional, Stevens, Fiona M, additional, O'Morain, Colm, additional, Kennedy, Nicholas P, additional, Kelleher, Dermot, additional, Pennington, Daniel J, additional, Strachan, David P, additional, McArdle, Wendy L, additional, Mein, Charles A, additional, Wapenaar, Martin C, additional, Deloukas, Panos, additional, McGinnis, Ralph, additional, McManus, Ross, additional, Wijmenga, Cisca, additional, and van Heel, David A, additional

Published
2008
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84. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

Author

van Heel, David A, primary, Franke, Lude, additional, Hunt, Karen A, additional, Gwilliam, Rhian, additional, Zhernakova, Alexandra, additional, Inouye, Mike, additional, Wapenaar, Martin C, additional, Barnardo, Martin C N M, additional, Bethel, Graeme, additional, Holmes, Geoffrey K T, additional, Feighery, Con, additional, Jewell, Derek, additional, Kelleher, Dermot, additional, Kumar, Parveen, additional, Travis, Simon, additional, Walters, Julian RF, additional, Sanders, David S, additional, Howdle, Peter, additional, Swift, Jill, additional, Playford, Raymond J, additional, McLaren, William M, additional, Mearin, M Luisa, additional, Mulder, Chris J, additional, McManus, Ross, additional, McGinnis, Ralph, additional, Cardon, Lon R, additional, Deloukas, Panos, additional, and Wijmenga, Cisca, additional

Published
2007
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87. Impact on parents of HLA-DQ2/DQ8 genotyping in healthy children from coeliac families.

Author

Wessels, Margreet M S, Vriezinga, Sabine L, Koletzko, Sybille, Werkstetter, Katharina, Castillejo-De Villasante, Gemma, Shamir, Raanan, Hartman, Corina, Putter, Hein, van der Pal, Sylvia M, Wijmenga, Cisca, Bravi, Enzo, and Mearin, M Luisa

Subjects
CELIAC disease in children, HLA histocompatibility antigen genetics, GENOTYPES, CELIAC disease, CHILDREN'S health, QUALITY of life, GENETICS, PREVENTION
Abstract

Due to the association of coeliac disease and HLA-specificities DQ2 and DQ8, HLA-typing can be used for risk determination of the disease. This study was designed to evaluate the knowledge of parents from coeliac families regarding HLA-typing and the impact of HLA-typing on the perception of the health of their children. A structured questionnaire was sent to the Dutch, Spanish and German parents participating with their child in the European PreventCD study on disease prevention in high-risk families, addressing parents' understanding of and attitude towards HLA-typing, distress related to HLA-typing and perceived health and health-related quality of life of their children. Sixty-eight percent of parents of 515 children returned the questionnaires, with 85% of children being DQ2/DQ8 positive. The majority of all parents answered the questions on knowledge correctly. Forty-eight percent of parents of DQ2/DQ8-negative children thought their child could develop coeliac disease. More distress was reported by parents of DQ2/DQ8-positive children (P<0.001). All parents showed few regrets and would repeat HLA-typing in future children. Perceived health and health-related quality of life were similar. In conclusion, we can say that misinterpretation of DQ2/DQ8-negative results by parents is frequent. DQ2/DQ8-positive results do not affect perceived health and health-related quality of life of children but may cause temporary negative feelings among parents. Parents of coeliac families seem to support HLA-typing. [ABSTRACT FROM AUTHOR]

Published
2015
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89. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect

Author

Monsuur, Alienke J, primary, Bakker, Paul I W de, additional, Alizadeh, Behrooz Z, additional, Zhernakova, Alexandra, additional, Bevova, Marianna R, additional, Strengman, Eric, additional, Franke, Lude, additional, Slot, Ruben van't, additional, Belzen, Martine J van, additional, Lavrijsen, Ineke C M, additional, Diosdado, Begoña, additional, Daly, Mark J, additional, Mulder, Chris J J, additional, Mearin, M Luisa, additional, Meijer, Jos W R, additional, Meijer, Gerrit A, additional, Oort, Erica van, additional, Wapenaar, Martin C, additional, Koeleman, Bobby P C, additional, and Wijmenga, Cisca, additional

Published
2005
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90. Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease

Author

Collin, Pekka, primary, Kaukinen, Katri, additional, Vogelsang, Harald, additional, Korponay-Szab??, Ilma, additional, Sommer, Rudolf, additional, Schreier, Elisabeth, additional, Volta, Umberto, additional, Granito, Alessandro, additional, Veronesi, Lorenza, additional, Mascart, Fran??oise, additional, Ocmant, Annick, additional, Ivarsson, Anneli, additional, Lagerqvist, Carina, additional, B??rgin-Wolff, Annemarie, additional, Hadziselimovic, Faruk, additional, Furlano, Raoul I, additional, Sidler, Marc A, additional, Mulder, Chris JJ, additional, Goerres, Marije S, additional, Mearin, M Luisa, additional, Ninaber, Maarten K, additional, Gudmand-H??yer, Eivind, additional, Fabiani, Elisabetta, additional, Catassi, Carlo, additional, Tidlund, Helena, additional, Alainentalo, Lisbeth, additional, and M??ki, Markku, additional

Published
2005
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94. Neonatal hemochromatosis: management, outcome, and prevention.

Author

Lopriore, Enrico, Mearin, M. Luisa, Oepkes, Dick, Devlieger, Roland, and Whitington, Peter F.

Abstract

ABSTRACT Neonatal hemochromatosis (NH) is a rare disorder but the most common cause of acute liver failure in neonates. NH is characterized by severe hepatic injury and iron overload and is associated with high perinatal mortality and morbidity rates. NH is often preceded by oligohydramnios and intrauterine growth restriction, suggesting an important impact of NH during fetal life. Stillbirth and prematurity are not uncommon. During the last decade, major discoveries on the etiology of NH have radically changed the management and outcome of this disease. NH is now regarded as an alloimmune disease and is, as such, often referred to as gestational alloimmune liver disease. Antenatal treatment with intravenous immunoglobulins starting at 14 weeks' gestation has been shown to prevent the development of NH in subsequent pregnancies. Postnatal treatment, previously based on the use of anti-oxidants and chelation therapy, has now successfully been replaced by exchange transfusions and intravenous immunoglobulins substitution. This review summarizes the latest discoveries on the etiology of NH and the new recommendations concerning its management and prevention. © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2013
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95. European multi-centre study on coeliac disease and non-Hodgkin lymphoma.

Author

Mearin ML, Catassi C, Brousse N, Brand R, Collin P, Fabiani E, Schweizer JJ, Abuzakouk M, Szajewska H, Hallert C, Farré Masip C, Holmes GK, Biomed Study Group on Coeliac Disease and Non-Hodgkin Lymphoma, Mearin, M Luisa, Catassi, Carlo, Brousse, Nicole, Brand, Ronald, Collin, Pekka, Fabiani, Elisabetta, and Schweizer, Joachim J

Published
2006
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96. CDDUX: A Disease-specific Health-related Quality-of-life Questionnaire for Children With Celiac Disease

Author

Doorn, Roesja K, Winkler, Lex MF, Zwinderman, Koos H, Mearin, M Luisa, and Koopman, Hendrik M

Abstract

The development of a disease-specific, health-related, quality-of-life questionnaire for children ages 8 to 18 with celiac disease (CD), together with a parent-as-proxy version. We used a focus-group method (bottom-up approach) to investigate the impact of CD on children's everyday lives and selected 24 items to create a preliminary disease-specific questionnaire. This questionnaire, together with the complementary generic quality-of-life questionnaire DUX-25, was sent to 756 children with CD in the Netherlands and was returned by 530 of them. With the help of statistical analyses (Cronbach a, factor analysis, Pearson correlation, Student ttest, paired samples ttest, and item response theory), we tested the psychometric performance of the 24 items. We reduced the questionnaire to 12 items: the Celiac Disease DUX (CDDUX). The CDDUX has 3 subscales: “Communication” (3), “Diet” (6), and “Having CD” (3). This questionnaire proved to be reliable, valid, and feasible and able to discriminate between perception of severity in cases of CD as assessed by parents. Children with a better perception of their own health status have a higher score on the CDDUX questionnaire. The whole group seems to have a lower quality of life than the healthy reference group on all domains of the DUX-25. The new disease-specific questionnaire CDDUX provides information about how children with CD think and feel about their illness. The questionnaire may enable researchers and clinicians to determine the consequences of this illness and the effects of clinical interventions on several aspects of daily living.

Published
2008
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98. Gluten and dyspepsia.

Author

Mearin, M. Luisa

Subjects
*CELIAC disease diagnosis, *INDIGESTION diagnosis, *CELIAC disease, *EPITHELIUM, *GASTROENTEROLOGY, *GLUTEN, *IMMUNOGLOBULINS, *HLA-B27 antigen
Abstract

The author reflects on the occurrence, symptoms and diagnosis of celiac disease (CD), which leads to the flattening of epithelial lining of small bowel and usually lead to malabsorption, malnutrition and diaarhoea. The study conducted by Rostami Nejad and colleagues demonstrate the presence of CD in dyspepsia patients. The study also demonstrates the benefits of adopting a gluten free diet for better symptoms in such patients.

Published
2012

99. Systematic review: early feeding practices and the risk of coeliac disease. A 2022 update and revision

Author

Szajewska, H., Shamir, R., Strozyk, A., Chmielewska, A., Zalewski, B.M., Auricchio, R., Koletzko, S., Korponay-Szabo, I.R., Mearin, M.L., Meijer, C., Ribes-Koninckx, C., Troncone, R., PreventCD Project Grp, Szajewska, Hania, Shamir, Raanan, Stróżyk, Agata, Chmielewska, Anna, Zalewski, Bartłomiej M, Auricchio, Renata, Koletzko, Sibylle, Korponay-Szabo, Ilma R, Mearin, M Luisa, Meijer, Caroline, Ribes-Koninckx, Carmen, and Troncone, Riccardo

Subjects
Celiac Disease, Hepatology, Gastroenterology, Humans, Pharmacology (medical), Evidence Gaps
Abstract

Background: The effects of early feeding practices on the risk of coeliac disease (CD) remain debated. Aims: To update evidence on these practices on the risk of CD and/or CD-related autoimmunity (CDA), defined as anti-transglutaminase or anti-endomysial antibody positivity. Methods: We searched MEDLINE, EMBASE and the Cochrane Library to May 2022 for randomised controlled trials (RCTs) and observational studies. Results: We included 36 publications (30 studies). In the population at genetic risk of developing CD (HLA DQ2/DQ8-positive), exclusive or any breastfeeding and longer breastfeeding duration did not reduce the risk of developing CD/CDA during childhood. While a meta-analysis of four case–control studies showed a decreased risk for CD when gluten was introduced during breastfeeding, this was not shown in RCTs and cohort studies. Age at gluten introduction was not associated with cumulative CD/CDA risk, although two RCTs suggested that earlier gluten introduction was associated with earlier CDA appearance. Evidence from six observational studies suggests that consumption of a higher amount of gluten at weaning and/or thereafter may increase CD risk. There is insufficient evidence to determine the amount of gluten associated with an increased CD/CDA risk. Regarding whether infant feeding practices modulate the risk conferred by different HLA genotypes results were inconsistent. Conclusions: For the population at genetic risk of CD, breastfeeding and age at gluten introduction have no effect on its cumulative incidence during childhood. There is some evidence for an effect of the amount of gluten consumed at weaning and/or thereafter on CD/CDA risk.

Published
2022

100. The impact of human breast milk components on the infant metabolism

Author

Olaf Uhl, Isabel Polanco, María Roca, Sabine L. Vriezinga, Renata Auricchio, Maria Grunewald, Gemma Castillejo, M. Luisa Mearin, Ilma Rita Korponay-Szabó, Franca F. Kirchberg, Katharina J. Werkstetter, Christian Hellmuth, Hans Demmelmair, Berthold Koletzko, Hellmuth, Christian, Uhl, Olaf, Demmelmair, Han, Grunewald, Maria, Auricchio, Renata, Castillejo, Gemma, Korponay-Szabo, Ilma R, Polanco, Isabel, Roca, María, Vriezinga, Sabine L, Werkstetter, Katharina J, Koletzko, Berthold, Mearin, M Luisa, and Kirchberg, Franca F

Subjects
0301 basic medicine, Serum Proteins, Physiology, Protein metabolism, Breastfeeding, lcsh:Medicine, Biochemistry, chemistry.chemical_compound, Families, 0302 clinical medicine, Endocrinology, Lactation, Medicine and Health Sciences, Metabolites, Insulin, lcsh:Science, Child, Infant Nutritional Physiological Phenomena, Breast Milk, Children, Protein Metabolism, 2. Zero hunger, chemistry.chemical_classification, Mother, Multidisciplinary, Lysophosphatidylcholine, food and beverages, Orvostudományok, Milk Proteins, Blood proteins, Infant Formula, 3. Good health, Body Fluids, medicine.anatomical_structure, Milk, Blood, Breast Feeding, Female, Anatomy, Infants, Human, Polyunsaturated fatty acid, Research Article, Adult, Mothers, 030209 endocrinology & metabolism, Breast milk, Klinikai orvostudományok, Milk Protein, Beverages, 03 medical and health sciences, Fatty Acids, Omega-6, Fatty Acids, Omega-3, medicine, Humans, Nutrition, Diabetic Endocrinology, 030109 nutrition & dietetics, Milk, Human, business.industry, lcsh:R, Infant, Newborn, Biology and Life Sciences, Proteins, Infant, Lysophosphatidylcholines, Hormones, Diet, Metabolism, chemistry, Infant formula, Age Groups, People and Places, lcsh:Q, Population Groupings, business, Breast feeding
Abstract

Background & aims Breastfeeding is beneficial for mothers and infants. Underlying mechanisms and biochemical mediators thus need to be investigated to develop and support improved infant nutrition practices promoting the child health. We analysed the relation between maternal breast milk composition and infant metabolism. Methods 196 pairs of mothers and infants from a European research project (PreventCD) were studied. Maternal milk samples collected at month 1 and month 4 after birth were analysed for macronutrient classes, hormone, and fatty acid (FA) content. Phospholipids, acylcarnitines, and amino acids were measured in serum samples of 4-month old infants. Associations between milk components and infant metabolites were analysed with spearman correlation and linear mixed effect models (LME). P-values were corrected for multiple testing (P-LME). Results Month 1 milk protein content was strongly associated with infant serum lyso-phosphatidylcholine (LPC) 14: 0 (P-LME = 0.009). Month 1 milk insulin was associated to infant acetylcarnitine (P-LME = 0.01). There were no associations between milk protein content and serum amino acids and milk total fat content and serum polar lipids. Middle- and odd-chain FA% in breast milk at both ages were significantly related to serum LPC and sphingomyelins (SM) species in infant serum (all P-LME < 0.05), while FA% 20: 5n(-3) and 22: 6n(-3) percentages were significantly associated to serum LPC 22:6 (P-LME = 1.91x10(-4)/7.93x10(-5)) in milk only at month 4. Other polyunsaturated fatty acids and hormones in milk showed only weak associations with infant serum metabolites. Conclusions Infant serum LPC are influenced by breast milk FA composition and, intriguingly, milk protein content in early but not late lactation. LPC 14:0, previously found positively associated with obesity risk, was the serum metabolite which was the most strongly associated to milk protein content. Thus, LPC 14:0 might be a key metabolite not only reflecting milk protein intake in infants, but also relating high protein content in milk or infant formula to childhood obesity risk.

Published
2018

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