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59. Abstract 12940: Shared Senescence Pathophysiology in Preeclampsia and Peripartum Cardiomyopathy

Author

Roh, Jason D, primary, Yu, Andy, additional, Rana, Sarosh, additional, SHAHUL, Sajid, additional, Castro, Claire, additional, Honigberg, Michael, additional, Ricke-Hoch, Melanie, additional, Yeri, Ashish, additional, Kitchen, Robert, additional, Hobson, Ryan, additional, Chaudhari, Vinita, additional, Chang, Bliss, additional, Sarma, Amy, additional, Kirkland, James, additional, Karumanchi, Ananth, additional, Gorcsan, John, additional, Masataka, Sugahara, additional, Damp, Julie B, additional, Hanley-Yanez, Karen, additional, Arany, Zoltan, additional, McNamara, Dennis M, additional, Hilfiker-Kleiner, Denise, additional, and Rosenzweig, Anthony, additional

Published
2021
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60. Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies

Author

Ware, James S., Li, Jian, Mazaika, Erica, Yasso, Christopher M., DeSouza, Tiffany, Cappola, Thomas P., Tsai, Emily J., Hilfiker-Kleiner, Denise, Kamiya, Chizuko A., Mazzarotto, Francesco, Cook, Stuart A., Halder, Indrani, Prasad, Sanjay K., Pisarcik, Jessica, Hanley-Yanez, Karen, Alharethi, Rami, Damp, Julie, Hsich, Eileen, Elkayam, Uri, Sheppard, Richard, Kealey, Angela, Alexis, Jeffrey, Ramani, Gautam, Safirstein, Jordan, Boehmer, John, Pauly, Daniel F., Wittstein, Ilan S., Thohan, Vinay, Zucker, Mark J., Liu, Peter, Gorcsan, John, III, McNamara, Dennis M., Seidman, Christine E., Seidman, Jonathan G., and Arany, Zoltan

Published
2016
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62. Proinflammatory TH17 cytokine activation, disease severity and outcomes in peripartum cardiomyopathy

Author

Koczo, Agnes, primary, Marino, Amy, additional, Rocco, Joseph, additional, Ewald, Gregory, additional, Givertz, Michael M., additional, Rajagopalan, Navin, additional, Bozkurt, Biykem, additional, Elkayam, Uri, additional, Cooper, Leslie T., additional, Fett, James, additional, McTiernan, Charles F., additional, Morel, Penelope A., additional, Hanley-Yanez, Karen, additional, and McNamara, Dennis M., additional

Published
2021
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64. Genetic Variants Are Not Associated with Outcome in Patients with Coronary Artery Disease and Left Ventricular Dysfunction: Results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) Trials

Author

Feldman, Arthur M., She, Lilin, McNamara, Dennis M., Mann, Douglas L., Bristow, Michael R., Maisel, Alan S., Wagner, Daniel R., Andersson, Bert, Chiariello, Luigi, Hayward, Christopher S., Hendry, Paul, Parker, John D., Racine, Normand, Selzman, Craig H., Senni, Michele, Stepinska, Janina, Zembala, Marian, Rouleau, Jean, Velazquez, Eric J., and Lee, Kerry L.

Published
2015
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66. Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease

Author

Teekakirikul, Polakit, primary, Zhu, Wenjuan, additional, Gabriel, George C., additional, Young, Cullen B., additional, Williams, Kylia, additional, Martin, Lisa J., additional, Hill, Jennifer C., additional, Richards, Tara, additional, Billaud, Marie, additional, Phillippi, Julie A., additional, Wang, Jianbin, additional, Wu, Yijen, additional, Tan, Tuantuan, additional, Devine, William, additional, Lin, Jiuann-huey, additional, Bais, Abha S., additional, Klonowski, Jonathan, additional, de Bellaing, Anne Moreau, additional, Saini, Ankur, additional, Wang, Michael X., additional, Emerel, Leonid, additional, Salamacha, Nathan, additional, Wyman, Samuel K., additional, Lee, Carrie, additional, Li, Hung Sing, additional, Miron, Anastasia, additional, Zhang, Jingyu, additional, Xing, Jianhua, additional, McNamara, Dennis M., additional, Fung, Erik, additional, Kirshbom, Paul, additional, Mahle, William, additional, Kochilas, Lazaros K., additional, He, Yihua, additional, Garg, Vidu, additional, White, Peter, additional, McBride, Kim L., additional, Benson, D. Woodrow, additional, Gleason, Thomas G., additional, Mital, Seema, additional, and Lo, Cecilia W., additional

Published
2021
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67. Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy

Author

Seferović, Petar M., primary, Tsutsui, Hiroyuki, additional, McNamara, Dennis M., additional, Ristić, Arsen D., additional, Basso, Cristina, additional, Bozkurt, Biykem, additional, Cooper, Leslie T., additional, Filippatos, Gerasimos, additional, Ide, Tomomi, additional, Inomata, Takayuki, additional, Klingel, Karin, additional, Linhart, Aleš, additional, Lyon, Alexander R., additional, Mehra, Mandeep R., additional, Polovina, Marija, additional, Milinković, Ivan, additional, Nakamura, Kazufumi, additional, Anker, Stefan D., additional, Veljić, Ivana, additional, Ohtani, Tomohito, additional, Okumura, Takahiro, additional, Thum, Thomas, additional, Tschöpe, Carsten, additional, Rosano, Giuseppe, additional, Coats, Andrew J.S., additional, and Starling, Randall C., additional

Published
2021
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68. Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy

Author

Goli, Rahul, Li, Jian, Brandimarto, Jeff, Levine, Lisa D., Riis, Valerie, McAfee, Quentin, Depalma, Steven, Haghighi, Alireza, Seidman, J. G., Seidman, Christine E., Jacoby, Daniel, Macones, George, Judge, Daniel P., Rana, Sarosh, Margulies, Kenneth B., Cappola, Thomas P., Alharethi, Rami, Damp, Julie, Hsich, Eileen, Elkayam, Uri, Sheppard, Richard, Alexis, Jeffrey D., Boehmer, John, Kamiya, Chizuko, Gustafsson, Finn, Damm, Peter, Ersbøll, Anne S., Goland, Sorel, Hilfiker-Kleiner, Denise, McNamara, Dennis M., Arany, Zolt, Goli, Rahul, Li, Jian, Brandimarto, Jeff, Levine, Lisa D., Riis, Valerie, McAfee, Quentin, Depalma, Steven, Haghighi, Alireza, Seidman, J. G., Seidman, Christine E., Jacoby, Daniel, Macones, George, Judge, Daniel P., Rana, Sarosh, Margulies, Kenneth B., Cappola, Thomas P., Alharethi, Rami, Damp, Julie, Hsich, Eileen, Elkayam, Uri, Sheppard, Richard, Alexis, Jeffrey D., Boehmer, John, Kamiya, Chizuko, Gustafsson, Finn, Damm, Peter, Ersbøll, Anne S., Goland, Sorel, Hilfiker-Kleiner, Denise, McNamara, Dennis M., and Arany, Zolt

Abstract

Background: Peripartum cardiomyopathy (PPCM) occurs in ≈1:2000 deliveries in the United States and worldwide. The genetic underpinnings of PPCM remain poorly defined. Approximately 10% of women with PPCM harbor truncating variants in TTN (TTNtvs). Whether mutations in other genes can predispose to PPCM is not known. It is also not known if the presence of TTNtvs predicts clinical presentation or outcomes. Nor is it known if the prevalence of TTNtvs differs in women with PPCM and preeclampsia, the strongest risk factor for PPCM. Methods: Women with PPCM were retrospectively identified from several US and international academic centers, and clinical information and DNA samples were acquired. Next-generation sequencing was performed on 67 genes, including TTN, and evaluated for burden of truncating and missense variants. The impact of TTNtvs on the severity of clinical presentation, and on clinical outcomes, was evaluated. Results: Four hundred sixty-nine women met inclusion criteria. Of the women with PPCM, 10.4% bore TTNtvs (odds ratio=9.4 compared with 1.2% in the reference population; Bonferroni-corrected P [P∗]=1.2×10-46). We additionally identified overrepresentation of truncating variants in FLNC (odds ratio=24.8, P∗=7.0×10-8), DSP (odds ratio=14.9, P∗=1.0×10-8), and BAG3 (odds ratio=53.1, P∗=0.02), genes not previously associated with PPCM. This profile is highly similar to that found in nonischemic dilated cardiomyopathy. Women with TTNtvs had lower left ventricular ejection fraction on presentation than did women without TTNtvs (23.5% versus 29%, P=2.5×10-4), but did not differ significantly in timing of presentation after delivery, in prevalence of preeclampsia, or in rates of clinical recovery. Conclusions: This study provides the first extensive genetic and phenotypic landscape of PPCM and demonstrates that predisposition to heart failure is an important risk factor for PPCM. The work reveals a degree of genet

Published
2021

76. Contributors

Author

Acker, Michael, primary, Adams, Kirkwood F., additional, Anand, Inder S., additional, Anker, Stefan D., additional, Anversa, Piero, additional, Baicu, Catalin F., additional, Baker, Kenneth M., additional, Beanlands, Rob S., additional, Bethmann, Kerstin, additional, Bickford, Courtney L., additional, Boerrigter, Guido, additional, Bogaev, Roberta C., additional, Bonow, Robert O., additional, Booker, Julian, additional, Bozkurt, Biykem, additional, Bristow, Michael R., additional, Burnett, John C., additional, Cantillon, Daniel J., additional, Carabello, Blase A., additional, Cohn, Jay N., additional, Colucci, Wilson S., additional, Cooper, Leslie T., additional, Costello-Boerrigter, Lisa, additional, Daniels, Lori B., additional, Delgado, Reynolds M., additional, Deswal, Anita, additional, Diwan, Abhinav, additional, Doehner, Wolfram, additional, Dokainish, Hisham, additional, Dorn, Gerald W., additional, Drexler, Helmut, additional, Feldman, Arthur M., additional, Felker, G. Michael, additional, Flaherty, James D., additional, Floras, John S., additional, Florea, Viorel G., additional, Francis, Gary S., additional, Franklin, Wayne, additional, Frazier, O.H., additional, Freidrich, Matthias, additional, Freudenberger, Ronald S., additional, Gheorghiade, Mihai, additional, Giles, Thomas D., additional, Gottlieb, Stephen, additional, Hassan, Yusuf, additional, Havranek, Edward P., additional, Homma, Shunichi, additional, Hornig, Burkhard, additional, Houser, Steven R., additional, Ingwall, Joanne S., additional, Javaheri, Shahrokh, additional, Jefferies, John Lynn, additional, Jessup, Mariell, additional, Jha, Saurabh, additional, Kajstura, Jan, additional, Kass, David A., additional, Katz, Arnold M., additional, Kitsis, Richard N., additional, Konstam, Marvin A., additional, Konstam, Varda, additional, Kraus, William E., additional, Kumar, Rajesh, additional, Landmesser, Ulf, additional, Le Jemtel, Thierry H., additional, Lehmann, Ilana, additional, Leri, Annarosa, additional, LeWinter, Martin M., additional, Liang, Chang-Seng, additional, Maisel, Alan S., additional, Mancini, Donna M., additional, Mann, Douglas L., additional, Marian, Ali J., additional, Margulies, Kenneth B., additional, Maurer, Matthew, additional, McNamara, Dennis M., additional, Mehra, Mandeep R., additional, Méndez Machado, Gustavo F., additional, Metra, Marco, additional, Moser, Debra K., additional, Mullens, Wilfried, additional, Owen, Ashleigh A., additional, Pan, Jing, additional, Patten, Richard D., additional, Pereira, Naveen, additional, Peterson, Linda R., additional, Piña, Ileana L., additional, Podrid, Philip J., additional, Port, J. David, additional, Ramasubbu, Kumudha, additional, Riegel, Barbara, additional, Sandler, G.E., additional, Sawyer, Douglas B., additional, Schilling, Joel, additional, Slavin, Leo, additional, Spinale, Francis G., additional, Starling, Randall C., additional, Stevenson, Lynne Warner, additional, Sucharov, Carmen, additional, Taegtmeyer, Heinrich, additional, Tang, W.H. Wilson, additional, Taylor, Anne L., additional, Teerlink, John R., additional, Topkara, Veli K., additional, Towbin, Jeffrey A., additional, Uber, Patricia A., additional, VanBuren, Peter, additional, Vasan, Ramachandran S., additional, Velagaleti, Raghava S., additional, von Haehling, Stephan, additional, Wilkoff, Bruce L., additional, Wollert, Kai C., additional, Yeh, Edward T.H., additional, Young, James B., additional, Ziadi, Maria C., additional, and Zile, Michael R., additional

Published
2011
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78. Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study

Author

Chen, Qi, Reis, Steven E., Kammerer, Candace M., McNamara, Dennis M., Holubkov, Richard, Sharaf, Barry L., Sopko, George, Pauly, Daniel F., Merz, C. Noel Bairey, and Kamboh, M. Ilyas

Subjects
High density lipoproteins -- Physiological aspects, High density lipoproteins -- Genetic aspects, Coronary heart disease -- Physiological aspects, Coronary heart disease -- Genetic aspects, Ischemia -- Physiological aspects, Ischemia -- Genetic aspects, Polymorphism (Zoology) -- Physiological aspects, Polymorphism (Zoology) -- Genetic aspects, Biological sciences
Published
2003

82. Heart Transplantation

Author

Hsich, Eileen M., primary, Blackstone, Eugene H., additional, Thuita, Lucy W., additional, McNamara, Dennis M., additional, Rogers, Joseph G., additional, Yancy, Clyde W., additional, Goldberg, Lee R., additional, Valapour, Maryam, additional, Xu, Gang, additional, and Ishwaran, Hemant, additional

Published
2020
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84. Peripartum Cardiomyopathy

Author

Davis, Melinda B., primary, Arany, Zolt, additional, McNamara, Dennis M., additional, Goland, Sorel, additional, and Elkayam, Uri, additional

Published
2020
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85. Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy

Author

Koczo, Agnes, primary, Marino, Amy, additional, Jeyabalan, Arun, additional, Elkayam, Uri, additional, Cooper, Leslie T., additional, Fett, James, additional, Briller, Joan, additional, Hsich, Eileen, additional, Blauwet, Lori, additional, McTiernan, Charles, additional, Morel, Penelope A., additional, Hanley-Yanez, Karen, additional, McNamara, Dennis M., additional, McNamara, Dennis M, additional, Fett, James D., additional, Pisarcik, Jessica, additional, Gorcsan, John, additional, Schelbert, Erik, additional, Alharethi, Rami, additional, Rasmusson, Kismet, additional, Brunisholz, Kim, additional, Butler, Amy, additional, Budge, Deborah, additional, Kfoury, A.G., additional, Horne, Benjamin, additional, Tuinei, Joe, additional, Brown, Heather, additional, Damp, Julie, additional, Naftilan, Allen J., additional, Russell, Jill, additional, Freehardt, Darla, additional, Oblak, Cynthia, additional, Ewald, Greg, additional, Whitehead, Donna, additional, Flanagan, Jean, additional, Platts, Anne, additional, Caro, Jorge, additional, Mullin, Stephanie, additional, Givertz, Michael M., additional, Anello, M. Susan, additional, Rajagopalan, Navin, additional, Booth, David, additional, Sandlin, Tiffany, additional, Wijesiri, Wendy, additional, Blauwet, Lori A., additional, Brunner, Joann, additional, Phelps, Mary, additional, Kempf, Ruth, additional, Modi, Kalgi, additional, Norwood, Tracy, additional, Griza, Decebal Sorin, additional, Felker, G. Michael, additional, Kociol, Robb, additional, Adams, Patricia, additional, Wells, Gretchen, additional, Thohan, Vinay, additional, Wesley-Farrington, Deborah, additional, Soots, Sandra, additional, Sheppard, Richard, additional, Michel, Caroline, additional, Lapointe, Nathalie, additional, Nathaniel, Heather, additional, Kealey, Angela, additional, Semigran, Marc, additional, Daher, Maureen, additional, Boehmer, John, additional, Silber, David, additional, Popjes, Eric, additional, Frey, Patricia, additional, Nicklas, Todd, additional, Alexis, Jeffrey, additional, Caufield, Lori, additional, Thornton, John W., additional, Gentry, Mindy, additional, Robinson, Vincent J.B., additional, Sharma, Gyanendra K., additional, Holloway, Joan, additional, Powell, Maria, additional, Markham, David, additional, Drazner, Mark, additional, Fernandez, Lynn, additional, Zucker, Mark, additional, Baran, David A., additional, Gimovsky, Martin L., additional, Hochbaum, Natalia, additional, Patel, Bharati, additional, Adams, Laura, additional, Ramani, Gautam, additional, Gottlieb, Stephen, additional, Robinson, Shawn, additional, Fisher, Stacy, additional, Marshall, Joanne, additional, Haythe, Jennifer, additional, Mancini, Donna, additional, Bijou, Rachel, additional, Farr, Maryjane, additional, Marks, Marybeth, additional, Arango, Henry, additional, Bozkurt, Biykem, additional, Bolos, Mariana, additional, Mather, Paul, additional, Rubin, Sharon, additional, Bonita, Raphael, additional, Eberwine, Susan, additional, Skopicki, Hal, additional, Stergiopoulos, Kathleen, additional, McCathy-Santoro, Ellen, additional, Intravaia, Jennifer, additional, Maas, Elizabeth, additional, Safirstein, Jordan, additional, Kleet, Audrey, additional, Martinez, Nancy, additional, Corpoin, Christine, additional, Hesari, Donna, additional, Chaparro, Sandra, additional, Hudson, Laura J., additional, Ghali, Jalal K., additional, Injic, Zora, additional, and Wittstein, Ilan S., additional

Published
2019
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86. Reply

Author

Koczo, Agnes, primary, Marino, Amy, additional, and McNamara, Dennis M., additional

Published
2019
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94. Myocarditis

Author

Feldman, Arthur M. and McNamara, Dennis M.

Published
2001

96. Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography

Author

LaFramboise William A, Dhir Rajiv, Kelly Lori A, Petrosko Patricia, Krill-Burger John M, Sciulli Christin M, Lyons-Weiler Maureen A, Chandran Uma R, Lomakin Aleksey, Masterson Robert V, Marroquin Oscar C, Mulukutla Suresh R, and McNamara Dennis M

Subjects
atherosclerosis, biomarkers, cardiac catheterization, coronary angiography, coronary stenosis, multiplex proteomics, Medicine
Abstract

Abstract Background More than a million diagnostic cardiac catheterizations are performed annually in the US for evaluation of coronary artery anatomy and the presence of atherosclerosis. Nearly half of these patients have no significant coronary lesions or do not require mechanical or surgical revascularization. Consequently, the ability to rule out clinically significant coronary artery disease (CAD) using low cost, low risk tests of serum biomarkers in even a small percentage of patients with normal coronary arteries could be highly beneficial. Methods Serum from 359 symptomatic subjects referred for catheterization was interrogated for proteins involved in atherogenesis, atherosclerosis, and plaque vulnerability. Coronary angiography classified 150 patients without flow-limiting CAD who did not require percutaneous intervention (PCI) while 209 required coronary revascularization (stents, angioplasty, or coronary artery bypass graft surgery). Continuous variables were compared across the two patient groups for each analyte including calculation of false discovery rate (FDR ≤ 1%) and Q value (P value for statistical significance adjusted to ≤ 0.01). Results Significant differences were detected in circulating proteins from patients requiring revascularization including increased apolipoprotein B100 (APO-B100), C-reactive protein (CRP), fibrinogen, vascular cell adhesion molecule 1 (VCAM-1), myeloperoxidase (MPO), resistin, osteopontin, interleukin (IL)-1β, IL-6, IL-10 and N-terminal fragment protein precursor brain natriuretic peptide (NT-pBNP) and decreased apolipoprotein A1 (APO-A1). Biomarker classification signatures comprising up to 5 analytes were identified using a tunable scoring function trained against 239 samples and validated with 120 additional samples. A total of 14 overlapping signatures classified patients without significant coronary disease (38% to 59% specificity) while maintaining 95% sensitivity for patients requiring revascularization. Osteopontin (14 times) and resistin (10 times) were most frequently represented among these diagnostic signatures. The most efficacious protein signature in validation studies comprised osteopontin (OPN), resistin, matrix metalloproteinase 7 (MMP7) and interferon γ (IFNγ) as a four-marker panel while the addition of either CRP or adiponectin (ACRP-30) yielded comparable results in five protein signatures. Conclusions Proteins in the serum of CAD patients predominantly reflected (1) a positive acute phase, inflammatory response and (2) alterations in lipid metabolism, transport, peroxidation and accumulation. There were surprisingly few indicators of growth factor activation or extracellular matrix remodeling in the serum of CAD patients except for elevated OPN. These data suggest that many symptomatic patients without significant CAD could be identified by a targeted multiplex serum protein test without cardiac catheterization thereby eliminating exposure to ionizing radiation and decreasing the economic burden of angiographic testing for these patients.

Published
2012
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97. Electromagnetic Interference from Left Ventricular Assist Device (LVAD) Inhibiting the Pacing Function of an Implantable Cardioverter-Defibrillator (ICD) Device

Author

Erqou, Sebhat, Kormos, Robert L., Wang, Norman C., McNamara, Dennis M., and Bazaz, Raveen

Subjects
Article Subject, equipment and supplies
Abstract

There is an increasing prevalence of patients with concomitant implantable cardioverter-defibrillators (ICDs) and left ventricular devices (LVADs). The potential for negative interactions between these continually evolving technologies is a valid concern. Previously reported interactions include inappropriate ICD therapy and interference with ICD telemetry function. Understanding the nature of such interactions and developing a comprehensive strategy to approach such situations are important. In this report, we describe a case of electromagnetic interference from LVAD inhibiting the pacing function of an ICD that was corrected by reprograming the device. We would encourage investigators to review patients with ICD and LVAD in their institutions in order to help assess the frequency and nature of these and other interactions.

Published
2018
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100. Elevated Sera sST2 Is Associated With Heart Failure in Men ≤50 Years Old With Myocarditis

Author

Coronado, Michael J., primary, Bruno, Katelyn A., additional, Blauwet, Lori A., additional, Tschöpe, Carsten, additional, Cunningham, Madeleine W., additional, Pankuweit, Sabine, additional, van Linthout, Sophie, additional, Jeon, Eun‐Seok, additional, McNamara, Dennis M., additional, Krejčí, Jan, additional, Bienertová‐Vašků, Julie, additional, Douglass, Erika J., additional, Abston, Eric D., additional, Bucek, Adriana, additional, Frisancho, J. Augusto, additional, Greenaway, Merci S., additional, Hill, Anneliese R., additional, Schultheiss, Heinz‐Peter, additional, Cooper, Leslie T., additional, and Fairweather, DeLisa, additional

Published
2019
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