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51. Irish endocrine society: Proceedings of meeting held 7th/8th November, 1997

Author

Gleeson, A., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Sexton, D. M., Creedon, G., Ledwith, M., Griffin, M., O’Meara, N., Collins, P. B., Kilbane, M. T., Tuite, A. M., Shering, S. G., Smith, D. F., McDermott, F. W. M., O’Higgins, N. J., Smyth, P. P. A., McKenna, K., Thompson, C. J., Kohler, W. M., O’Shea, D., Alaghband-Zadeh, J., Latham, K., Carter, G., Smyth, P. P. A., Shering, S. G., Kilbane, M. T., McDermott, E. W. M., Smith, D. F., O’Higgins, N. J., Lovell, S. L., Leslie, H., Doherty, C., Hadden, D. R., McGeown, Mary G., Kinsley, B. T., McKenna, T. J., Byrne, P. M., Gallagher, C., McKennal, M. J., Li Voon Chong, S. W., Darby, C., Freyne, P., Cullen, M. J., McKone, E., Heffernan, A., Darko, D. A., Kyrialcides, E., O’Shea, D., Burr, R., Carter, G., Armstrong, V. L., Ennis, C. N., Hunter, S. J., Sheridan, B., Atkinson, A. B., Bell, P. M., Giblin, L., Griffin, M. E., Otridge, B., O’Meara, N. M., Kinsley, B. T., Weinger, K., Bajaj, M., Levy, C. J., Waters, M., Simonson, D. C., Cox, D. J., Jacobson, A. M., Armstrong, V. L., Ennis, C. N., Sheridan, B., Atkinson, A. B., Bell, P. M., Traub, A. I., Creedon, G., Sexton, D., Griffin, M., O’Meara, N., Collins, P., Wiggam, M. I., Bell, P. M., Sheridan, B., Walmsley, A. E., Atkinson, A. B., Leary, A. C., Grealy, G., Higgins, T. M., Buckley, N., Barry, D. G., Murphy, D., Ferriss, J. B., McConnell, E. M., Bell, P. M., Hadden, D. R., McCance, R., Atkinson, A. B., Nikookam, K., Suliman, M. E., Carroll, M., Webster, J., Wilson, R. M., Cullen, D. R., McAllister, A. S., McCance, D. R., Hadden, D. R., Bell, P. M., Leslie, H., Sheridan, B., Atkinson, A. B., Alavi, Z., O’Hare, J. A., McAllister, A. S., Atkinson, A. B., McCance, D. R., Johnston, G. D., McKenna, M. J., and Freaney, R.

Published
1998
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52. Elexacaftor-tezacaftor-ivacaftor for cystic fibrosis with a single Phe508del allele

Author

Middleton, P. G., Mall, M. A., Drevinek, P., Lands, L. C., Mckone, E. F., Polineni, D., Ramsey, B. W., Taylor-Cousar, J. L., Tullis, E., Vermeulen, F., Marigowda, G., Mckee, C. M., Moskowitz, S. M., Nair, N., Savage, J., Simard, C., Tian, S., Waltz, D., Xuan, F., Rowe, S. M., Jain, R., Magazzu, G., Clinical sciences, Physiotherapy, Human Physiology and Anatomy, and Pediatrics

Subjects
Male, Adolescent, Adult, Aminophenols, Benzodioxoles, Child, Chloride Channel Agonists, Chlorides, Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator, Double-Blind Method, Drug Combinations, Female, Forced Expiratory Volume, Genotype, Humans, Indoles, Pyrazoles, Pyridines, Pyrrolidines, Quinolones, Sweat, Young Adult, Mutation, 030204 cardiovascular system & hematology, medicine.disease_cause, Gastroenterology, Cystic fibrosis, Ivacaftor, chemistry.chemical_compound, 0302 clinical medicine, 030212 general & internal medicine, biology, Lumacaftor, General Medicine, Cystic fibrosis transmembrane conductance regulator, medicine.drug, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Article, 03 medical and health sciences, Internal medicine, medicine, Allele, business.industry, Potentiator, medicine.disease, chemistry, biology.protein, business
Abstract

BACKGROUND: Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, and nearly 90% of patients have at least one copy of the Phe508del CFTR mutation. In a phase 2 trial involving patients who were heterozygous for the Phe508del CFTR mutation and a minimal-function mutation (Phe508del-minimal function genotype), the next-generation CFTR corrector elexacaftor, in combination with tezacaftor and ivacaftor, improved Phe508del CFTR function and clinical outcomes. METHODS: We conducted a phase 3, randomized, double-blind, placebo-controlled trial to confirm the efficacy and safety of elexacaftor-tezacaftor-ivacaftor in patients 12 years of age or older with cystic fibrosis with Phe508del-minimal function genotypes. Patients were randomly assigned to receive elexacaftor-tezacaftor-ivacaftor or placebo for 24 weeks. The primary end point was absolute change from baseline in percentage of predicted forced expiratory volume in 1 second (FEV1) at week 4. RESULTS: A total of 403 patients underwent randomization and received at least one dose of active treatment or placebo. Elexacaftor-tezacaftor-ivacaftor, relative to placebo, resulted in a percentage of predicted FEV1 that was 13.8 points higher at 4 weeks and 14.3 points higher through 24 weeks, a rate of pulmonary exacerbations that was 63% lower, a respiratory domain score on the Cystic Fibrosis Questionnaire-Revised (range, 0 to 100, with higher scores indicating a higher patient-reported quality of life with regard to respiratory symptoms; minimum clinically important difference, 4 points) that was 20.2 points higher, and a sweat chloride concentration that was 41.8 mmol per liter lower (P

Published
2019

55. Royal Academy of Medicine in Ireland Section of Biological Sciences Proceedings of Winter Meeting at Earlsfort Terrace, University College Dublin, 4th January 1991

Author

Boyle, C., Sheppard, B. L., Bonnar, J., Jordan, Marie, Norris, L. A., Sharma, S. C., McKone, E., Gleeson, N., Quigley, J., Gonsalves, R., McGuinness, E., Rowan, M. J., Penney, L., Anwyl, R., O’Mahony, D., Feely, J., Walsh, J. B., Coakley, D., Omara, A. A. M., Lambert, M. B., Deasy, P. B., Chambers, B. J., Klein, N. W., Hall, Elizabeth F., Hall, W. J., Nugent, Anne-Marie, Carragher, Angela M., Prasanna, K., Nicholls, D. P., Gibbons, J. R. P., McGuigan, J. A., McMillan, C. M., Dundee, J. W., Abram, W. P., Fee, J. P. H., Collier, P. S., Clarke, R. S. J., McKinney, M. S., Craig, S. F., Grealy, M., Kelly, J., O’Donnell, J. M., Martin, Catherine A., Leonard, B. E., Baxter, G. D., Allen, J. M., Bell, A. J., Ravey, J., Mokhtar, B., Doherty, D., Houghton, J. A., Gaffney, P. J., Creighton-Kempsford, L. J., Tymkewycz, P. M., Parmo, J. A., Gascoine, P. S., Pring, J. B., Longstaff, C., Grimm, T., Mulpeter, K., Chan, R., Doolan, C., Burke-Gaffney, Anne, Cooney, Deirdre, Keenan, A. K., Kelly, M., Reilly, M., Ryan, F., Keegan, L., Martin, F. Finian, O’Keane, P., Mannion, D., Fitzpatrick, G., Kirby, F., McCaul, C., McGrath, K., O’Donovan, F., McDonald, N., McShane, A. J., Bannigan, J., Cottell, D. C., Bradford, A., Mahon, J., Barrett, R. P., Homer, C. H., Arbuthnott, E., O’Brien, M., Crotty, T. P., Cooney, C. M., O’Leary, E., Bourke, J., Phelan, D., Moriarty, D. C., and Blunnie, W. P.

Published
1991
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56. Royal academy of medicine in ireland section of biological sciences: Proceedings of the section of biological sciences section, summer meeting, ucg, 23rd & 24th june, 1989.

Author

McCabe, J. P., Waldron, R. P., Kerin, M. J., Courtney, D. F., Given, H. F., McAnena, O. J., Grimes, H., Tymkewycz, P. M., Gascoine, P. S., Gaffney, P. J., Felle, P., Gaine, S., Cox, J., England, R., Walsh, J., Coakley, D., Feely, J., O’Brien, E., O’Malley, K., Daly, L., Sheppard, B. L., Carroll, E., Hennelly, B., Bonnar, J., Fahy, M. M., Carragher, V., Kane, M. T., McGuinness, S., Pratt, I., Ryan, M. P., Cahill, P. A., Daly, S., Keenan, A. K., Barrett, R. P., Rowan, M. J., Smyth, Maria, O’Cuinn, G., Sharma, S. C., Sheppard, B. L., Bonnar, J., Feely, S., Kennedy, M., O’Regan, R. G., Hughes, Gwen, Allen, J. M., McHale, N. G., Thombury, K. D., Croal, S., Anderson, J. McC, Allen, J. D., Jamison, J. P., Mercer, C. G., Gracey, A. E., Flynn, N., Otoole, D. P., O’Malley, K., Clery, A. P., Cunningham, A. J., Dundee, J. W., Ghaly, R. G., Yang, Jing, Sharma, S. C., Etwebi, A. B., Alazreg, A. A., Lavelle, S. M., Etwebi, A., Comerford, F. R., Donohoe, N., Kagashe, Godeliver A. B., Leonard, B. E., Kelly, J. P., Bannon, C., Nolan, P., Bradford, A., McGlynn, H., Kavanagh, B., Bullock, Caroline G., O’Connor, Brigid A., Pippard, Corinna J., Wallace, W. F. M., Holland, P. C., Pratt, I., Ryan, M. P., Blake, M., Redmond, E., Keenan, A. K., Redmond, E. M., Brennan, M., Anwyl, R., Gaynor, A., Luckwill, R. G., Caldwell, M., Lyons, O., McNamara, D., Lynott, A., Fleming, F., Walsh, R., Farrell, L., Homer, C. H., Glacken, P., O’Brien, M., Caird, J., Grogan, A., Ng, C. Y., Glacken, P., O’Brien, M., Arora, A., Carroll, M., McKone, E., O’Gradaigh, D., O’Reilly, P. M. R., FitzGerald, M. J. T., Tierney, S., Russell, J., and Folan, J. C.

Published
1990
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62. Irish endocrine society

Author

Gleeson, A., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Sexton, D. M., Creedon, G., Ledwith, M., Griffin, M., OʼMeara, N., Collins, P. B., Kilbane, M. T., Tuite, A. M., Shering, S. G., Smith, D. F., McDermott, F. W. M., OʼHiggins, N. J., Smyth, P. P. A., McKenna, K., Thompson, C. J., Kohler, W. M., OʼShea, D., Alaghband-Zadeh, J., Latham, K., Carter, G., McDermott, E. W. M., Lovell, S. L., Leslie, H., Doherty, C., Hadden, D. R., McGeown, Mary G., Kinsley, B. T., McKenna, T. J., Byrne, P. M., Gallagher, C., McKennal, M. J., Li Voon Chong, S. W., Darby, C., Freyne, P., Cullen, M. J., McKone, E., Heffernan, A., Darko, D. A., Kyrialcides, E., Burr, R., Armstrong, V. L., Ennis, C. N., Hunter, S. J., Sheridan, B., Atkinson, A. B., Bell, P. M., Giblin, L., Griffin, M. E., Otridge, B., OʼMeara, N. M., Weinger, K., Bajaj, M., Levy, C. J., Waters, M., Simonson, D. C., Cox, D. J., Jacobson, A. M., Traub, A. I., Sexton, D., Wiggam, M. I., Walmsley, A. E., Leary, A. C., Grealy, G., Higgins, T. M., Buckley, N., Barry, D. G., Murphy, D., Ferriss, J. B., McConnell, E. M., McCance, R., Nikookam, K., Suliman, M. E., Carroll, M., Webster, J., Wilson, R. M., Cullen, D. R., McAllister, A. S., McCance, D. R., Alavi, Z., OʼHare, J. A., Johnston, G. D., McKenna, M. J., and Freaney, R.

Published
1998
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64. Subjective self-assessment of face recognition ability is only weakly related to objective measures of face recognition performance

Author

Laguesse, R, Tez, T, Hall, B, Irons, J, Mckone, E, Daini, R, Albonico, A, Malaspina, M, Taylor, E, Rhodes, G, Charpentier, A, Rossion, B, Palermo, R, McKone, E, Palermo, R., DAINI, ROBERTA, ALBONICO, ANDREA, MALASPINA, MANUELA, Laguesse, R, Tez, T, Hall, B, Irons, J, Mckone, E, Daini, R, Albonico, A, Malaspina, M, Taylor, E, Rhodes, G, Charpentier, A, Rossion, B, Palermo, R, McKone, E, Palermo, R., DAINI, ROBERTA, ALBONICO, ANDREA, and MALASPINA, MANUELA

Published
2013

74. Importance of the inverted control in measuring holistic face processing with the composite effect and part-whole effect.

Author

McKone, E, Davies, AA, Darke, H, Crookes, K, Wickramariyaratne, T, Zappia, S, Fiorentini, C, Favelle, S, Broughton, M, Fernando, D, McKone, E, Davies, AA, Darke, H, Crookes, K, Wickramariyaratne, T, Zappia, S, Fiorentini, C, Favelle, S, Broughton, M, and Fernando, D

Abstract

Holistic coding for faces is shown in several illusions that demonstrate integration of the percept across the entire face. The illusions occur upright but, crucially, not inverted. Converting the illusions into experimental tasks that measure their strength - and thus index degree of holistic coding - is often considered straightforward yet in fact relies on a hidden assumption, namely that there is no contribution to the experimental measure from secondary cognitive factors. For the composite effect, a relevant secondary factor is size of the "spotlight" of visuospatial attention. The composite task assumes this spotlight can be easily restricted to the target half (e.g., top-half) of the compound face stimulus. Yet, if this assumption were not true then a large spotlight, in the absence of holistic perception, could produce a false composite effect, present even for inverted faces and contributing partially to the score for upright faces. We review evidence that various factors can influence spotlight size: race/culture (Asians often prefer a more global distribution of attention than Caucasians); sex (females can be more global); appearance of the join or gap between face halves; and location of the eyes, which typically attract attention. Results from five experiments then show inverted faces can sometimes produce large false composite effects, and imply that whether this happens or not depends on complex interactions between causal factors. We also report, for both identity and expression, that only top-half face targets (containing eyes) produce valid composite measures. A sixth experiment demonstrates an example of a false inverted part-whole effect, where encoding-specificity is the secondary cognitive factor. We conclude the inverted face control should be tested in all composite and part-whole studies, and an effect for upright faces should be interpreted as a pure measure of holistic processing only when the experimental design produces no effect inverte

Published
2013

81. Subjective self-assessment of face recognition ability is only weakly related to objective measures of face recognition performance

Author

Laguesse, R., primary, Tez, T., additional, Hall, B., additional, Irons, J., additional, McKone, E., additional, Daini, R., additional, Albonico, A., additional, Malaspina, M., additional, Taylor, E., additional, Rhodes, G., additional, Charpentier, A., additional, Rossion, B., additional, and Palermo, R., additional

Published
2013
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90. Validation and use of a parametric model for projecting cystic fibrosis survivorship beyond observed data: a birth cohort analysis

Author

Jackson, A. D., primary, Daly, L., additional, Jackson, A. L., additional, Kelleher, C., additional, Marshall, B. C., additional, Quinton, H. B., additional, Fletcher, G., additional, Harrington, M., additional, Zhou, S., additional, McKone, E. F., additional, Gallagher, C., additional, Foley, L., additional, and Fitzpatrick, P., additional

Published
2011
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