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527 results on '"McEvoy, Andrew W."'

51. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults

Author

Ferreira-Atuesta, Carolina, primary, de Tisi, Jane, additional, McEvoy, Andrew W, additional, Miserocchi, Anna, additional, Khoury, Jean, additional, Yardi, Ruta, additional, Vegh, Deborah T, additional, Butler, James, additional, Lee, Hamin J, additional, Deli-Peri, Victoria, additional, Yao, Yi, additional, Wang, Feng-Peng, additional, Zhang, Xiao-Bin, additional, Shakhatreh, Lubna, additional, Siriratnam, Pakeeran, additional, Neal, Andrew, additional, Sen, Arjune, additional, Tristram, Maggie, additional, Varghese, Elizabeth, additional, Biney, Wendy, additional, Gray, William P, additional, Peralta, Ana Rita, additional, Rainha-Campos, Alexandre, additional, Gonçalves-Ferreira, António J C, additional, Pimentel, José, additional, Arias, Juan Fernando, additional, Terman, Samuel, additional, Terziev, Robert, additional, Lamberink, Herm J, additional, Braun, Kees P J, additional, Otte, Willem M, additional, Rugg-Gunn, Fergus J, additional, Gonzalez, Walter, additional, Bentes, Carla, additional, Hamandi, Khalid, additional, O'Brien, Terence J, additional, Perucca, Piero, additional, Yao, Chen, additional, Burman, Richard J, additional, Jehi, Lara, additional, Duncan, John S, additional, Sander, Josemir W, additional, Koepp, Matthias, additional, and Galovic, Marian, additional

Published
2022
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60. Optimal Surgical Extent for Memory and Seizure Outcome in Temporal Lobe Epilepsy

Author

Sone, Daichi; https://orcid.org/0000-0001-9617-706X, Ahmad, Maria, Thompson, Pamela J, Baxendale, Sallie, Vos, Sjoerd B, Xiao, Fenglai; https://orcid.org/0000-0003-1308-6539, de Tisi, Jane, McEvoy, Andrew W, Miserocchi, Anna, Duncan, John S, Koepp, Matthias J, Galovic, Marian; https://orcid.org/0000-0002-2307-071X, Sone, Daichi; https://orcid.org/0000-0001-9617-706X, Ahmad, Maria, Thompson, Pamela J, Baxendale, Sallie, Vos, Sjoerd B, Xiao, Fenglai; https://orcid.org/0000-0003-1308-6539, de Tisi, Jane, McEvoy, Andrew W, Miserocchi, Anna, Duncan, John S, Koepp, Matthias J, and Galovic, Marian; https://orcid.org/0000-0002-2307-071X

Abstract

OBJECTIVE Postoperative memory decline is an important consequence of anterior temporal lobe resection (ATLR) for temporal lobe epilepsy (TLE), and the extent of resection may be a modifiable factor. This study aimed to define optimal resection margins for cognitive outcome while maintaining a high rate of postoperative seizure freedom. METHODS This cohort study evaluated the resection extent on postoperative structural MRI using automated voxel-based methods and manual measurements in 142 consecutive patients with unilateral drug refractory TLE (74 left, 68 right TLE) who underwent standard ATLR. RESULTS Voxel-wise analyses revealed that postsurgical verbal memory decline correlated with resections of the posterior hippocampus and inferior temporal gyrus, whereas larger resections of the fusiform gyrus were associated with worsening of visual memory in left TLE. Limiting the posterior extent of left hippocampal resection to 55% reduced the odds of significant postoperative verbal memory decline by a factor of 8.1 (95% CI 1.5-44.4, p = 0.02). Seizure freedom was not related to posterior resection extent, but to the piriform cortex removal after left ATLR. In right TLE, variability of the posterior extent of resection was not associated with verbal and visual memory decline or seizures after surgery. INTERPRETATION The extent of surgical resection is an independent and modifiable risk factor for cognitive decline and seizures after left ATLR. Adapting the posterior extent of left ATLR might optimize postoperative outcome, with reduced risk of memory impairment while maintaining comparable seizure-freedom rates. The current, more lenient, approach might be appropriate for right ATLR. ANN NEUROL 2021.

Published
2022

62. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

Author

Blumcke, Ingmar, Spreafico, Roberto, Haaker, Gerrit, Coras, Roland, Kobow, Katja, Bien, Christian G., Pfäfflin, Margarete, Elger, Christian, Widman, Guido, Schramm, Johannes, Becker, Albert, Braun, Kees P., Leijten, Frans, Baayen, Johannes C., Aronica, Eleonora, Chassoux, Francine, Hamer, Hajo, Stefan, Hermann, Rössler, Karl, Thom, Maria, Walker, Matthew C., Sisodiya, Sanjay M., Duncan, John S., McEvoy, Andrew W., Pieper, Tom, Holthausen, Hans, Kudernatsch, Manfred, Meencke, Joachim H., Kahane, Philippe, Schulze-Bonhage, Andreas, Zentner, Josef, Heiland, Dieter H., Urbach, Horst, Steinhoff, Bernhard J., Bast, Thomas, Tassi, Laura, Lo Russo, Giorgio, Özkara, Cigdem, Oz, Buge, Krsek, Pavel, Vogelgesang, Silke, Runge, Uwe, Lerche, Holger, Weber, Yvonne, Honavar, Mrinalini, Pimentel, José, Arzimanoglou, Alexis, Ulate-Campos, Adriana, Noachtar, Soheyl, Hartl, Elisabeth, Schijns, Olaf, Guerrini, Renzo, Barba, Carmen, Jacques, Thomas S., Cross, Helen J., Feucht, Martha, Mühlebner, Angelika, Grunwald, Thomas, Trinka, Eugen, Winkler, Peter A., Gil-Nagel, Antonio, Delgado, Rafael Toledano, Mayer, Thomas, Lutz, Martin, Zountsas, Basilios, Garganis, Kyriakos, Rosenow, Felix, Hermsen, Anke, von Oertzen, Tim J., Diepgen, Thomas L., and Avanzini, Giuliano

Published
2017
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68. Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near‐infrared window

Author

Shapey, Jonathan, primary, Xie, Yijing, additional, Nabavi, Elham, additional, Ebner, Michael, additional, Saeed, Shakeel R., additional, Kitchen, Neil, additional, Dorward, Neil, additional, Grieve, Joan, additional, McEvoy, Andrew W., additional, Miserocchi, Anna, additional, Grover, Patrick, additional, Bradford, Robert, additional, Lim, Yau‐Mun, additional, Ourselin, Sebastien, additional, Brandner, Sebastian, additional, Jaunmuktane, Zane, additional, and Vercauteren, Tom, additional

Published
2022
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71. Normative brain mapping of interictal intracranial EEG to localize epileptogenic tissue

Author

Taylor, Peter N, primary, Papasavvas, Christoforos A, additional, Owen, Thomas W, additional, Schroeder, Gabrielle M, additional, Hutchings, Frances E, additional, Chowdhury, Fahmida A, additional, Diehl, Beate, additional, Duncan, John S, additional, McEvoy, Andrew W, additional, Miserocchi, Anna, additional, de Tisi, Jane, additional, Vos, Sjoerd B, additional, Walker, Matthew C, additional, and Wang, Yujiang, additional

Published
2022
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74. Orienting to fear under transient focal disruption of the human amygdala.

Author

Jha, Ashwani, Diehl, Beate, Strange, Bryan, Miserocchi, Anna, Chowdhury, Fahmida, McEvoy, Andrew W, and Nachev, Parashkev

Subjects
AMYGDALOID body, SUPERIOR colliculus, PARTIAL epilepsy, SELF-expression, FEAR, ELECTRIC stimulation
Abstract

Responding to threat is under strong survival pressure, promoting the evolution of systems highly optimized for the task. Though the amygdala is implicated in 'detecting' threat, its role in the action that immediately follows—'orienting'—remains unclear. Critical to mounting a targeted response, such early action requires speed, accuracy, and resilience optimally achieved through conserved, parsimonious, dedicated systems, insured against neural loss by a parallelized functional organization. These characteristics tend to conceal the underlying substrate not only from correlative methods but also from focal disruption over time scales long enough for compensatory adaptation to take place. In a study of six patients with intracranial electrodes temporarily implanted for the clinical evaluation of focal epilepsy, we investigated gaze orienting to fear during focal, transient, unilateral direct electrical disruption of the amygdala. We showed that the amygdala is necessary for rapid gaze shifts towards faces presented in the contralateral hemifield regardless of their emotional expression, establishing its functional lateralization. Behaviourally dissociating the location of presented fear from the direction of the response, we implicated the amygdala not only in detecting contralateral faces, but also in automatically orienting specifically towards fearful ones. This salience-specific role was demonstrated within a drift-diffusion model of action to manifest as an orientation bias towards the location of potential threat. Pixel-wise analysis of target facial morphology revealed scleral exposure as its primary driver, and induced gamma oscillations—obtained from intracranial local field potentials—as its time-locked electrophysiological correlate. The amygdala is here reconceptualized as a functionally lateralized instrument of early action, reconciling previous conflicting accounts confined to detection, and revealing a neural organisation analogous to the superior colliculus, with which it is phylogenetically kin. Greater clarity on its role has the potential to guide therapeutic resection, still frequently complicated by impairments of cognition and behaviour related to threat, and inform novel focal stimulation techniques for the management of neuropsychiatric conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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76. Resection of the piriform cortex for temporal lobe epilepsy: a Novel approach on imaging segmentation and surgical application

Author

Leon-Rojas, Jose E, Iqbal, Sabahat, Vos, Sjoerd B, Rodionov, Roman, Miserocchi, Anna, McEvoy, Andrew W, Vakharia, Vejay N, Mancini, Laura, Galovic, Marian, Sparks, Rachel E, Ourselin, Sebastien, Cardoso, Jorge M, Koepp, Matthias J, Duncan, John S, University of Zurich, and Duncan, John S

Subjects
2728 Neurology (clinical), 610 Medicine & health, 10040 Clinic for Neurology, 2746 Surgery
Published
2021

83. Simulated Field Maps: Toward Improved Susceptibility Artefact Correction in Interventional MRI

Author

Kochan, Martin, primary, Daga, Pankaj, additional, Burgos, Ninon, additional, White, Mark, additional, Cardoso, M. Jorge, additional, Mancini, Laura, additional, Winston, Gavin P., additional, McEvoy, Andrew W., additional, Thornton, John, additional, Yousry, Tarek, additional, Duncan, John S., additional, Stoyanov, Danail, additional, and Ourselin, Sébastien, additional

Published
2014
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86. Resection of the piriform cortex for temporal lobe epilepsy: a Novel approach on imaging segmentation and surgical application

Author

Leon-Rojas, Jose E., primary, Iqbal, Sabahat, additional, Vos, Sjoerd B., additional, Rodionov, Roman, additional, Miserocchi, Anna, additional, McEvoy, Andrew W, additional, Vakharia, Vejay N, additional, Mancini, Laura, additional, Galovic, Marian, additional, Sparks, Rachel E, additional, Ourselin, Sebastien, additional, Cardoso, Jorge M, additional, Koepp, Matthias J, additional, and Duncan, John S, additional

Published
2021
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87. 'Hemispherical asymmetry in the Meyer's loop': a prospective study of visual-field deficits in 105 cases undergoing anterior temporal lobe resection for epilepsy

Author

Jeelani, N.u Owase, Jindahra, Panitha, Tamber, Mandeep S., Poon, Tak Lap, Kabasele, Paul, James-Galton, Merle, Stevens, John, Duncan, John, McEvoy, Andrew W., Harkness, William, and Plant, Gordon T.

Subjects
Temporal lobe epilepsy -- Care and treatment, Temporal lobe epilepsy -- Complications and side effects, Temporal lobe epilepsy -- Research, Hemispherectomy -- Complications and side effects, Hemispherectomy -- Research, Vision disorders -- Research, Visual cortex -- Physiological aspects, Visual cortex -- Research, Visual fields -- Physiological aspects, Visual fields -- Research, Health, Psychology and mental health
Published
2010

88. EEG correlated functional MRI and postoperative outcome in focal epilepsy

Author

Thornton, Rachel, Laufs, Helmut, Rodionov, Roman, Cannadathu, Sajitha, Carmichael, David W., Vulliemoz, Serge, Salek-Haddadi, Afraim, McEvoy, Andrew W., Smith, Shelagh M., Lhatoo, Samden, Elwes, Robert D.C., Guye, Maxime, Walker, Matthew C., Lemieux, Louis, and Duncan, John S.

Subjects
Epilepsy -- Care and treatment, Epilepsy -- Patient outcomes, Epilepsy -- Research, Electroencephalography -- Usage, Electroencephalography -- Research, Magnetic resonance imaging -- Usage, Magnetic resonance imaging -- Research, Outcome and process assessment (Health Care) -- Research, Hemispherectomy -- Patient outcomes, Hemispherectomy -- Research, Health, Psychology and mental health
Published
2010

96. The impact of epilepsy surgery on the structural connectome and its relation to outcome

Author

Taylor, Peter N, Sinha, Nishant, Wang, Yujiang, Vos, Sjoerd B, de Tisi, Jane, Miserocchi, Anna, McEvoy, Andrew W, Winston, Gavin P, and Duncan, John S

Subjects
Adult, Male, Support Vector Machine, Network, lcsh:Computer applications to medicine. Medical informatics, lcsh:RC346-429, Machine learning, Neural Pathways, Connectome, Image Processing, Computer-Assisted, Humans, Temporal lobe epilepsy, lcsh:Neurology. Diseases of the nervous system, Retrospective Studies, Brain Mapping, Epilepsy, Regular Article, Middle Aged, Anterior Temporal Lobectomy, Diffusion Magnetic Resonance Imaging, Treatment Outcome, FOS: Biological sciences, Quantitative Biology - Neurons and Cognition, lcsh:R858-859.7, Neurons and Cognition (q-bio.NC), Surgery, Female, Support vector machine (SVM)
Abstract

Background Temporal lobe surgical resection brings seizure remission in up to 80% of patients, with long-term complete seizure freedom in 41%. However, it is unclear how surgery impacts on the structural white matter network, and how the network changes relate to seizure outcome. Methods We used white matter fibre tractography on preoperative diffusion MRI to generate a structural white matter network, and postoperative T1-weighted MRI to retrospectively infer the impact of surgical resection on this network. We then applied graph theory and machine learning to investigate the properties of change between the preoperative and predicted postoperative networks. Results Temporal lobe surgery had a modest impact on global network efficiency, despite the disruption caused. This was due to alternative shortest paths in the network leading to widespread increases in betweenness centrality post-surgery. Measurements of network change could retrospectively predict seizure outcomes with 79% accuracy and 65% specificity, which is twice as high as the empirical distribution. Fifteen connections which changed due to surgery were identified as useful for prediction of outcome, eight of which connected to the ipsilateral temporal pole. Conclusion Our results suggest that the use of network change metrics may have clinical value for predicting seizure outcome. This approach could be used to prospectively predict outcomes given a suggested resection mask using preoperative data only., Highlights • Connection change pipeline predicts impact of epilepsy surgery on connectome. • Surgery leads to patient-specific reductions in efficiency, strength, region volumes. • Machine learning classifier retrospectively predicts outcome using network changes. • Pipeline could be used prospectively for intended surgery in future.

Published
2018

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