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53. Development of a PCR algorithm to detect and characterize Neisseria meningitidis carriage isolates in the African meningitis belt.

Author

Diallo, Kanny, Coulibaly, Mamadou D., Rebbetts, Lisa S., Harrison, Odile B., Lucidarme, Jay, Gamougam, Kadidja, Tekletsion, Yenenesh K., Bugri, Akalifa, Toure, Aliou, Issaka, Bassira, Dieng, Marietou, Trotter, Caroline, Collard, Jean-Marc, Sow, Samba O., Wang, Xin, Mayer, Leonard W., Borrow, Ray, Greenwood, Brian M., Maiden, Martin C. J., and Manigart, Olivier

Subjects
NEISSERIA meningitidis, DIAGNOSIS of bacterial diseases, POLYMERASE chain reaction, BACTERIA classification, IMMUNOSPECIFICITY
Abstract

Improved methods for the detection and characterization of carried Neisseria meningitidis isolates are needed. We evaluated a multiplex PCR algorithm for the detection of a variety of carriage strains in the meningitis belt. To further improve the sensitivity and specificity of the existing PCR assays, primers for gel-based PCR assays (sodC, H, Z) and primers/probe for real-time quantitative PCR (qPCR) assays (porA, cnl, sodC, H, E, Z) were modified or created using Primer Express software. Optimized multiplex PCR assays were tested on 247 well-characterised carriage isolates from six countries of the African meningitis belt. The PCR algorithm developed enabled the detection of N. meningitidis species using gel-based and real-time multiplex PCR targeting porA, sodC, cnl and characterization of capsule genes through sequential multiplex PCR assays for genogroups (A, W, X, then B, C, Y and finally H, E and Z). Targeting both porA and sodC genes together allowed the detection of meningococci with a sensitivity of 96% and 89% and a specificity of 78% and 67%, for qPCR and gel-based PCR respectively. The sensitivity and specificity ranges for capsular genogrouping of N. meningitidis are 67% - 100% and 98%-100% respectively for gel-based PCR and 90%-100% and 99%-100% for qPCR. We developed a PCR algorithm that allows simple, rapid and systematic detection and characterisation of most major and minor N. meningitidis capsular groups, including uncommon capsular groups (H, E, Z). [ABSTRACT FROM AUTHOR]

Published
2018
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54. Penicillin Use in Meningococcal Disease Management: Active Bacterial Core Surveillance Sites, 2009.

Author

Blain, Amy E, Blain, Amy E, Mandal, Sema, Wu, Henry, MacNeil, Jessica R, Harrison, Lee H, Farley, Monica M, Lynfield, Ruth, Miller, Lisa, Nichols, Megin, Petit, Sue, Reingold, Arthur, Schaffner, William, Thomas, Ann, Zansky, Shelley M, Anderson, Raydel, Harcourt, Brian H, Mayer, Leonard W, Clark, Thomas A, Cohn, Amanda C, Blain, Amy E, Blain, Amy E, Mandal, Sema, Wu, Henry, MacNeil, Jessica R, Harrison, Lee H, Farley, Monica M, Lynfield, Ruth, Miller, Lisa, Nichols, Megin, Petit, Sue, Reingold, Arthur, Schaffner, William, Thomas, Ann, Zansky, Shelley M, Anderson, Raydel, Harcourt, Brian H, Mayer, Leonard W, Clark, Thomas A, and Cohn, Amanda C

Abstract

In 2009, in the Active Bacterial Core surveillance sites, penicillin was not commonly used to treat meningococcal disease. This is likely because of inconsistent availability of antimicrobial susceptibility testing and ease of use of third-generation cephalosporins. Consideration of current practices may inform future meningococcal disease management guidelines.

Published
2016

55. Lack of Evidence for Chloramphenicol Resistance in Neisseria meningitidis, Africa

Author

Tondella, Maria-Lucia C., Rosenstein, Nancy E., Mayer, Leonard W., Tenover, Fred C., Stocker, Sheila A., Reeves, Mike W., and Popovic, Tanja

Subjects
Chloramphenicol -- Health aspects, Neisseria meningitidis -- Drug therapy, Drug resistance in microorganisms -- Research
Abstract

To the Editor: High-level chloramphenicol resistance has been reported in 11 epidemiologically unrelated Neisseria meningitidis serogroup B strains in Vietnam and in a single strain in France, all isolated between [...]

Published
2001

56. Genomic Investigation Reveals Highly Conserved, Mosaic, Recombination Events Associated with Capsular Switching among InvasiveNeisseria meningitidisSerogroup W Sequence Type (ST)-11 Strains

Author

Mustapha, Mustapha M., primary, Marsh, Jane W., additional, Krauland, Mary G., additional, Fernandez, Jorge O., additional, de Lemos, Ana Paula S., additional, Hotopp, Julie C. Dunning, additional, Wang, Xin, additional, Mayer, Leonard W., additional, Lawrence, Jeffrey G., additional, Hiller, N. Luisa, additional, and Harrison, Lee H., additional

Published
2016
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57. Development of Real-Time PCR Methods for the Detection of Bacterial Meningitis Pathogens without DNA Extraction

Author

Vuong, Jeni, primary, Collard, Jean-Marc, additional, Whaley, Melissa J., additional, Bassira, Issaka, additional, Seidou, Issaka, additional, Diarra, Seydou, additional, Ouédraogo, Rasmata T., additional, Kambiré, Dinanibè, additional, Taylor, Thomas H., additional, Sacchi, Claudio, additional, Mayer, Leonard W., additional, and Wang, Xin, additional

Published
2016
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58. Comparison of Phenotypic and Genotypic Approaches to Capsule Typing of Neisseria meningitidis by Use of Invasive and Carriage Isolate Collections

Author

Jones, C. Hal, primary, Mohamed, Naglaa, additional, Rojas, Eduardo, additional, Andrew, Lubomira, additional, Hoyos, Johanna, additional, Hawkins, Julio C., additional, McNeil, Lisa K., additional, Jiang, Qin, additional, Mayer, Leonard W., additional, Wang, Xin, additional, Gilca, Rodica, additional, De Wals, Philippe, additional, Pedneault, Louise, additional, Eiden, Joseph, additional, Jansen, Kathrin U., additional, and Anderson, Annaliesa S., additional

Published
2016
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59. Public Health Impact After the Introduction of PsA-TT: The First 4 Years

Author

Diomandé, Fabien V. K., primary, Djingarey, Mamoudou H., additional, Daugla, Doumagoum M., additional, Novak, Ryan T., additional, Kristiansen, Paul A., additional, Collard, Jean-Marc, additional, Gamougam, Kadidja, additional, Kandolo, Denis, additional, Mbakuliyemo, Nehemie, additional, Mayer, Leonard, additional, Stuart, James, additional, Clark, Thomas, additional, Tevi-Benissan, Carol, additional, Perea, William A., additional, Preziosi, Marie-Pierre, additional, Marc LaForce, F., additional, Caugant, Dominique, additional, Messonnier, Nancy, additional, Walker, Oladapo, additional, and Greenwood, Brian, additional

Published
2015
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61. BMC Infectious Diseases

Author

Wu, Henry M., Cordeiro, Soraia Machado, Harcourt, Brian H., Carvalho, Maria da Gloria S., Azevedo, Jailton, Oliveira, Tainara Q., Leite, Mariela C., Salgado, Katia, Reis, Mitermayer Galvão dos, Plikaytis, Brian D., Clark, Thomas A., Mayer, Leonard W., Ko, Albert I, Martin, Stacey W., and Reis, Joice N.

Subjects
Streptococcus pneumoniae Neisseria meningitidis, Bacterial meningitis, Haemophilus influenzae, Diagnostic test evaluation, Real-time PCR
Abstract

p. 1-10 Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-07-08T13:05:43Z No. of bitstreams: 1 444444444444.pdf: 281795 bytes, checksum: 594f3384ea132f663567fb63c1ab1d4e (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:43:19Z (GMT) No. of bitstreams: 1 444444444444.pdf: 281795 bytes, checksum: 594f3384ea132f663567fb63c1ab1d4e (MD5) Made available in DSpace on 2013-10-31T17:43:19Z (GMT). No. of bitstreams: 1 444444444444.pdf: 281795 bytes, checksum: 594f3384ea132f663567fb63c1ab1d4e (MD5) Previous issue date: 2013 Background: Although cerebrospinal fluid (CSF) culture is the diagnostic reference standard for bacterial meningitis, its sensitivity is limited, particularly when antibiotics were previously administered. CSF Gram staining and real-time PCR are theoretically less affected by antibiotics; however, it is difficult to evaluate these tests with an imperfect reference standard. Methods and findings: CSF from patients with suspected meningitis from Salvador, Brazil were tested with culture, Gram stain, and real-time PCR using S. pneumoniae, N. meningitidis, and H. influenzae specific primers and probes. An antibiotic detection disk bioassay was used to test for the presence of antibiotic activity in CSF. The diagnostic accuracy of tests were evaluated using multiple methods, including direct evaluation of Gram stain and real-time PCR against CSF culture, evaluation of real-time PCR against a composite reference standard, and latent class analysis modeling to evaluate all three tests simultaneously. Results: Among 451 CSF specimens, 80 (17.7%) had culture isolation of one of the three pathogens (40 S. pneumoniae, 36 N. meningitidis, and 4 H. influenzae), and 113 (25.1%) were real-time PCR positive (51 S. pneumoniae, 57 N. meningitidis, and 5 H. influenzae). Compared to culture, real-time PCR sensitivity and specificity were 95.0% and 90.0%, respectively. In a latent class analysis model, the sensitivity and specificity estimates were: culture, 81.3% and 99.7%; Gram stain, 98.2% and 98.7%; and real-time PCR, 95.7% and 94.3%, respectively. Gram stain and real-time PCR sensitivity did not change significantly when there was antibiotic activity in the CSF. Conclusion: Real-time PCR and Gram stain were highly accurate in diagnosing meningitis caused by S. pneumoniae, N. meningitidis, and H. influenzae, though there were few cases of H. influenzae. Furthermore, real-time PCR and Gram staining were less affected by antibiotic presence and might be useful when antibiotics were previously administered. Gram staining, which is inexpensive and commonly available, should be encouraged in all clinical settings. Salvador

Published
2013
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62. Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt

Author

Dakar discussion group on priorities for research on epidemic me, Altmann, Danny, Aseffa, Abraham, Bash, Margaret, Basta, Nicole, Borrow, Ray, Broome, Claire, Caugant, Dominique, Clark, Tom, Collard, Jean-Marc, Djingarey, Mamoudou, Goldblatt, David, Greenwood, Brian, Griffiths, Ulla, Hajjeh, Rana, Hassan-King, Musa, Hugonnet, Stephane, Kimball, Ann Marie, LaForce, Marc, MacLennan, Calman, Maiden, Martin CJ, Manigart, Olivier, Mayer, Leonard, Messonnier, Nancy, Moisi, Jennifer, Moore, Katie, Moto, Daugla Doumagoum, Mueller, Judith, Nascimento, Maria, Obaro, Stephen, Ouedraogo, Rasmata, Page, Anne-Laure, Perea, Willima, Pluschke, Gerd, Preziosi, Mari-Pierre, Sow, Samba, Stephens, David, Stuart, James, Thomson, Madeleiene, Tiendrebeogo, Sylvestre, Trape, Jean-Francois, and Vernet, Guy

Abstract

For over 100 years, large epidemics of meningococcal meningitis have occurred every few years in areas of the African Sahel and sub-Sahel known as the African meningitis belt. Until recently, the main approach to the control of these epidemics has been reactive vaccination with a polysaccharide vaccine after an outbreak has reached a defined threshold and provision of easy access to effective treatment but this approach has not prevented the occurrence of new epidemics. Meningococcal conjugate vaccines, which can prevent meningococcal carriage and thus interrupt transmission, may be more effective than polysaccharide vaccines at preventing epidemics. Because the majority of African epidemics have been caused by serogroup A meningococci, a serogroup A polysaccharide/tetanus toxoid protein conjugate vaccine (PsA-TT) has recently been developed. Results from an initial evaluation of the impact of this vaccine on meningococcal disease and meningococcal carriage in Burkina Faso have been encouraging. To review how the research agenda for meningococcal disease in Africa has been changed by the advent of PsA-TT and to define a new set of research priorities for study of meningococcal infection in Africa, a meeting of 41 scientists was held in Dakar, Senegal on April 24th and 25th 2012. The research recommendations developed during the course of this meeting are presented in this paper. The need for enhanced surveillance for meningitis in defined populations with good diagnostic facilities in African countries at risk of epidemics was identified as the highest priority. This is needed to determine the duration of protection against serogroup A meningococcal disease provided by PsA-TT and to determine the risk of disease and carriage caused by meningococci of other serogroups. Other research areas given high priority included identification and validation of serological correlates of protection against meningococcal disease and carriage, development of improved methods for detecting carriage and epidemiological studies aimed at determining the reasons underlying the peculiar epidemiology of meningococcal disease in the African meningitis belt. Minutes and working papers from the meeting are provided in supplementary tables and some of the presentations made at the meeting are available on the MenAfriCar consortium website (www.menafricar.org) and on the web site of the Centers for Disease Control (www.cdc.gov).

Published
2013

63. Outbreak of meningococcal disease associated with an elementary school--Oklahoma, March 2010

Author

Bradley, Kristy, Smithee, Lauri, Clark, Thomas, Wu, Henry, Mair, Raydel, Harcourt, Brian, Mayer, Leonard, Schmink, Susanna, Paddock, Christopher, Zaki, Sherif, and Grube, Steven

Subjects
Meningitis, Medical research, Medicine, Experimental, School districts, Elementary school students, Health
Abstract

During March 10-31, 2010, the Oklahoma State Department of Health (OSDH) investigated an outbreak of meningococcal (Neisseria meningitidis) disease involving a consolidated school district of 1,850 students in rural northeastern [...]

Published
2012

64. Genomic Epidemiology of Hypervirulent Serogroup W, ST-11 Neisseria meningitidis

Author

Mustapha, Mustapha M., primary, Marsh, Jane W., additional, Krauland, Mary G., additional, Fernandez, Jorge O., additional, de Lemos, Ana Paula S., additional, Dunning Hotopp, Julie C., additional, Wang, Xin, additional, Mayer, Leonard W., additional, Lawrence, Jeffrey G., additional, Hiller, N. Luisa, additional, and Harrison, Lee H., additional

Published
2015
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65. Changes in the Population Structure of InvasiveNeisseria meningitidisin the United States After Quadrivalent Meningococcal Conjugate Vaccine Licensure

Author

Wang, Xin, primary, Shutt, Kathleen A., additional, Vuong, Jeni T., additional, Cohn, Amanda, additional, MacNeil, Jessica, additional, Schmink, Susanna, additional, Plikaytis, Brian, additional, Messonnier, Nancy E., additional, Harrison, Lee H., additional, Clark, Thomas A., additional, and Mayer, Leonard W., additional

Published
2015
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67. Meningococcal Carriage Among Georgia and Maryland High School Students

Author

Harrison, Lee H., primary, Shutt, Kathleen A., additional, Arnold, Kathryn E., additional, Stern, Eric J., additional, Pondo, Tracy, additional, Kiehlbauch, Julia A., additional, Myers, Robert A., additional, Hollick, Rosemary A., additional, Schmink, Susanna, additional, Vello, Marianne, additional, Stephens, David S., additional, Messonnier, Nancy E., additional, Mayer, Leonard W., additional, and Clark, Thomas A., additional

Published
2014
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68. PCR-Based National Bacterial Meningitis Surveillance in Turkey

Author

Toprak, Demet, primary, Soysal, Ahmet, additional, Torunoğlu, Mehmet Ali, additional, Turgut, Mehmet, additional, Türkoğlu, Salih, additional, Pimenta, Fabiana Cristina, additional, da Gloria Carvalho, Maria, additional, Wang, Xin, additional, Mayer, Leonard, additional, Altnkanat, Gülşen, additional, Söyletir, Güner, additional, Mete, Birgül, additional, and Bakr, Mustafa, additional

Published
2014
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69. Neisseria meningitidisSerogroup W, Burkina Faso, 2012

Author

MacNeil, Jessica R., primary, Medah, Isaïe, additional, Koussoubé, Daouda, additional, Novak, Ryan T., additional, Cohn, Amanda C., additional, Diomandé, Fabien V.K., additional, Yelbeogo, Denis, additional, Kambou, Jean Ludovic, additional, Tarbangdo, Tiga F., additional, Ouédraogo-Traoré, Rasmata, additional, Sangaré, Lassana, additional, Hatcher, Cynthia, additional, Vuong, Jeni, additional, Mayer, Leonard W., additional, Djingarey, Mamoudou H., additional, Clark, Thomas A., additional, and Messonnier, Nancy E., additional

Published
2014
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70. Molecular characterization of Listeria monocytogenes isolated from foods

Author

Pimenta, Fabiana Cristina, Furlanetto, Sirdéia Maura Perrone, Mayer, Leonard W., Timenetsky, Jorge, and Santos, Manoel Armando Azevedo dos

Subjects
virulence, fatores de virulência, food, ribotipagem, alimentos, factors, ribotyping, Listeria monocytogenes
Abstract

A total of 30 strains of Listeria monocytogenes isolated from different foods (16 of differents kinds of sausage, 14 cheese,) purchased at groceries of São Paulo City were ribotyped and analysed for the presence and expression of hemolysin gene and production of phosphatidylinositol-specific phosphalipase C - PI-PLC enzyme. The L. monocytogenes strains were differentiated into six ribotype classes. A total of 13 (43.3%) from these strains belong to the same ribotype (ribotype I), and was coincident to the ribotype of the standard L. monocytogenes prototype strain (ATCC-15313). The hemolytic activity was observed in 29 (96.7%) strains when incubated at 37oC, but not at 4oC. The direct colony hybridization method for hemolysin gene detection showed a positive reaction whit all the 30 L. monocytogenes strains, while showed negative reaction with other Listeria spp. The PI-PLC was produced by 27 (90%) of the strains analysed. There was no correlation between the six identified ribotypes and the virulence factors (hemolysin and PI-PLC) studied. Foram estudadas 30 cepas de Listeria monocytogenes isoladas a partir de diferentes alimentos (16 diferentes tipos de linguiça, 14 de queijo), adquiridos em supermercados da cidade de São Paulo. As cepas foram classificadas através da ribotipagem e analisadas quanto à presença e expressão do gene da hemolisina e à produção da enzima fosfolipase C fosfatidilinositol-específica PI-PLC. As cepas de L. monocytogenes foram diferenciadas em 6 ribotipos. As cepas do tipo I possuiam o mesmo perfil da amostra padrão de L.monocytogenes (ATCC 15313), sendo 13 (43,3%) das cepas estudadas correspondentes a ele. A atividade hemolítica foi observada em 29 (96,7%) das cepas, quando incubadas a 37°C em agar sangue, mas não a 4°C. O método da hibridização direta de colônias, utilizando sonda para hemolisina, revelou resultado positivo para todas as cepas. A PI-PLC foi produzida por 90% das amostras analisadas. Deste modo, foi possível concluir que não há relação entre os seis ribotipos de L. monocytogenes identificados nesse estudo e os fatores de virulência estudados (hemolisina e PI-PLC).

Published
1999

71. A Multi-country Evaluation of Neisseria meningitidis Serogroup B Factor H–Binding Proteins and Implications for Vaccine Coverage in Different Age Groups

Author

Hoiseth, Susan K., primary, Murphy, Ellen, additional, Andrew, Lubomira, additional, Vogel, Ulrich, additional, Frosch, Matthias, additional, Hellenbrand, Wiebke, additional, Abad, Raquel, additional, Vazquez, Julio A., additional, Borrow, Ray, additional, Findlow, Jamie, additional, Taha, Muhamed-Kheir, additional, Deghmane, Ala-Eddine, additional, Caugant, Dominique A., additional, Kriz, Paula, additional, Musilek, Martin, additional, Mayer, Leonard W., additional, Wang, Xin, additional, MacNeil, Jessica R., additional, York, Laura, additional, Tan, Charles Y., additional, Jansen, Kathrin U., additional, and Anderson, Annaliesa S., additional

Published
2013
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73. Genomic Investigation Reveals Highly Conserved, Mosaic, Recombination Events Associated with Capsular Switching among Invasive Neisseria meningitidis SerogroupW Sequence Type (ST)-11 Strains.

Author

Mustapha, Mustapha M., Marsh, Jane W., Krauland, Mary G., Fernandez, Jorge O., De Lemos, Ana Paula S., Dunning Hotopp, Julie C., Xin Wang, Mayer, Leonard W., Lawrence, Jeffrey G., Luisa Hiller, N., and Harrison, Lee H.

Subjects
NEISSERIA meningitidis, SEQUENCE analysis, DNA mutational analysis, GENOMES, NUCLEOTIDE sequencing
Abstract

Neisseria meningitidis is an important cause of meningococcal disease globally. Sequence type (ST)-11 clonal complex (cc11) is a hypervirulentmeningococcal lineage historically associated with serogroupCcapsule and is believed to have acquired theWcapsule through a C toWcapsular switching event.We studied the sequence of capsule gene cluster (cps) and adjoining genomic regions of 524 invasiveWcc11 strains isolated globally.We identified recombination breakpoints corresponding to two distinct recombination events withinWcc11: A 8.4-kb recombinant region likely acquired fromWcc22 including the sialic acid/glycosyl-transferase gene, csw resulted in a C→W change in capsular phenotype and a 13.7-kb recombinant segment likely acquired from Y cc23 lineage includes 4.5 kbof cps genes and8.2 kbdownstreamof the cps cluster resulting in allelic changes in capsule translocation genes.Avast majority ofWcc11strains (497/524,94.8%) retainbothrecombination events as evidencedby sharing identicalor very closely related capsular allelic profiles. These data suggest that theW cc11 capsular switch involved two separate recombination events and that current globalWcc11 meningococcal disease is caused by strains bearing this mosaic capsular switch. [ABSTRACT FROM AUTHOR]

Published
2016
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75. Molecular Characterization of Invasive Meningococcal Isolates from Countries in the African Meningitis Belt before Introduction of a Serogroup A Conjugate Vaccine

Author

Caugant, Dominique A., primary, Kristiansen, Paul A., additional, Wang, Xin, additional, Mayer, Leonard W., additional, Taha, Muhamed-Kheir, additional, Ouédraogo, Rasmata, additional, Kandolo, Denis, additional, Bougoudogo, Flabou, additional, Sow, Samba, additional, and Bonte, Laurence, additional

Published
2012
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78. Effectively introducing a new meningococcal A conjugate vaccine in Africa: The Burkina Faso experience

Author

Djingarey, Mamoudou H., primary, Barry, Rodrigue, additional, Bonkoungou, Mete, additional, Tiendrebeogo, Sylvestre, additional, Sebgo, Rene, additional, Kandolo, Denis, additional, Lingani, Clement, additional, Preziosi, Marie-Pierre, additional, Zuber, Patrick L.F., additional, Perea, William, additional, Hugonnet, Stéphane, additional, Dellepiane de Rey Tolve, Nora, additional, Tevi-Benissan, Carole, additional, Clark, Thomas A., additional, Mayer, Leonard W., additional, Novak, Ryan, additional, Messonier, Nancy E., additional, Berlier, Monique, additional, Toboe, Desire, additional, Nshimirimana, Deo, additional, Mihigo, Richard, additional, Aguado, Teresa, additional, Diomandé, Fabien, additional, Kristiansen, Paul A., additional, Caugant, Dominique A., additional, and LaForce, F. Marc, additional

Published
2012
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80. Clinical Validation of Multiplex Real-Time PCR Assays for Detection of Bacterial Meningitis Pathogens

Author

Wang, Xin, primary, Theodore, M. Jordan, additional, Mair, Raydel, additional, Trujillo-Lopez, Elizabeth, additional, du Plessis, Mignon, additional, Wolter, Nicole, additional, Baughman, Andrew L., additional, Hatcher, Cynthia, additional, Vuong, Jeni, additional, Lott, Lisa, additional, von Gottberg, Anne, additional, Sacchi, Claudio, additional, McDonald, J. Matthew, additional, Messonnier, Nancy E., additional, and Mayer, Leonard W., additional

Published
2012
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81. Haemophilus influenzae Type b Carriage among Young Children in Metropolitan Atlanta in the Context of Vaccine Shortage and Booster Dose Deferral

Author

Thomas, Jennifer Dolan, primary, Jackson, Michael L., additional, Sharma, Dolly, additional, Mair, Raydel, additional, Bach, Michelle C., additional, Castillo, Dana, additional, Ejigiri, O. Grace, additional, Satola, Sarah, additional, Cohn, Amanda C., additional, Jerris, Robert, additional, Jain, Shabnam, additional, Farley, Monica M., additional, Mayer, Leonard W., additional, and Messonnier, Nancy E., additional

Published
2011
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82. Diversity of factor H-binding protein in Neisseria meningitidis carriage isolates

Author

Marsh, Jane W., primary, Shutt, Kathleen A., additional, Pajon, Rolando, additional, Tulenko, Mary M., additional, Liu, Stephen, additional, Hollick, Rosemary A., additional, Kiehlbauch, Julia A., additional, Clark, Thomas A., additional, Stephens, David S., additional, Arnold, Kathryn E., additional, Myers, Robert A., additional, Mayer, Leonard W., additional, and Harrison, Lee H., additional

Published
2011
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84. Prevalence and genetic diversity of candidate vaccine antigens among invasive Neisseria meningitidis isolates in the United States

Author

Wang, Xin, primary, Cohn, Amanda, additional, Comanducci, Maurizio, additional, Andrew, Lubomira, additional, Zhao, Xin, additional, MacNeil, Jessica R., additional, Schmink, Susanna, additional, Muzzi, Alessandro, additional, Bambini, Stefania, additional, Rappuoli, Rino, additional, Pizza, Mariagrazia, additional, Murphy, Ellen, additional, Hoiseth, Susan K., additional, Jansen, Kathrin U., additional, Anderson, Annaliesa S., additional, Harrison, Lee H., additional, Clark, Thomas A., additional, Messonnier, Nancy E., additional, and Mayer, Leonard W., additional

Published
2011
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85. Application of TaqMan Low-Density Arrays for Simultaneous Detection of Multiple Respiratory Pathogens

Author

Kodani, Maja, primary, Yang, Genyan, additional, Conklin, Laura M., additional, Travis, Tatiana C., additional, Whitney, Cynthia G., additional, Anderson, Larry J., additional, Schrag, Stephanie J., additional, Taylor, Thomas H., additional, Beall, Bernard W., additional, Breiman, Robert F., additional, Feikin, Daniel R., additional, Njenga, M. Kariuki, additional, Mayer, Leonard W., additional, Oberste, M. Steven, additional, Tondella, Maria Lucia C., additional, Winchell, Jonas M., additional, Lindstrom, Stephen L., additional, Erdman, Dean D., additional, and Fields, Barry S., additional

Published
2011
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86. sodC-Based Real-Time PCR for Detection of Neisseria meningitidis

Author

Dolan Thomas, Jennifer, primary, Hatcher, Cynthia P., additional, Satterfield, Dara A., additional, Theodore, M. Jordan, additional, Bach, Michelle C., additional, Linscott, Kristin B., additional, Zhao, Xin, additional, Wang, Xin, additional, Mair, Raydel, additional, Schmink, Susanna, additional, Arnold, Kathryn E., additional, Stephens, David S., additional, Harrison, Lee H., additional, Hollick, Rosemary A., additional, Andrade, Ana Lucia, additional, Lamaro-Cardoso, Juliana, additional, de Lemos, Ana Paula S., additional, Gritzfeld, Jenna, additional, Gordon, Stephen, additional, Soysal, Ahmet, additional, Bakir, Mustafa, additional, Sharma, Dolly, additional, Jain, Shabnam, additional, Satola, Sarah W., additional, Messonnier, Nancy E., additional, and Mayer, Leonard W., additional

Published
2011
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88. Neisseria Base: a comparative genomics database for Neisseria meningitidis

Author

Katz, Lee S., primary, Humphrey, Jay C., additional, Conley, Andrew B., additional, Nelakuditi, Viswateja, additional, Kislyuk, Andrey O., additional, Agrawal, Sonia, additional, Jayaraman, Pushkala, additional, Harcourt, Brian H., additional, Olsen-Rasmussen, Melissa A., additional, Frace, Michael, additional, Sharma, Nitya V., additional, Mayer, Leonard W., additional, and Jordan, I. King, additional

Published
2011
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89. Population Structure and Capsular Switching of InvasiveNeisseria meningitidisIsolates in the Pre–Meningococcal Conjugate Vaccine Era—United States, 2000–2005

Author

Harrison, Lee H., primary, Shutt, Kathleen A., additional, Schmink, Susanna E., additional, Marsh, Jane W., additional, Harcourt, Brian H., additional, Wang, Xin, additional, Whitney, Anne M., additional, Stephens, David S., additional, Cohn, Amanda A., additional, Messonnier, Nancy E., additional, and Mayer, Leonard W., additional

Published
2010
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90. Changes inNeisseria meningitidisDisease Epidemiology in the United States, 1998–2007: Implications for Prevention of Meningococcal Disease

Author

Cohn, Amanda C., primary, MacNeil, Jessica R., additional, Harrison, Lee H., additional, Hatcher, Cynthia, additional, Theodore, Jordan, additional, Schmidt, Mark, additional, Pondo, Tracy, additional, Arnold, Kathryn E., additional, Baumbach, Joan, additional, Bennett, Nancy, additional, Craig, Allen S., additional, Farley, Monica, additional, Gershman, Ken, additional, Petit, Susan, additional, Lynfield, Ruth, additional, Reingold, Arthur, additional, Schaffner, William, additional, Shutt, Kathleen A., additional, Zell, Elizabeth R., additional, Mayer, Leonard W., additional, Clark, Thomas, additional, Stephens, David, additional, and Messonnier, Nancy E., additional

Published
2010
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92. Etiologies of Bacterial Meningitis in Bangladesh: Results from a Hospital-Based Study

Author

Gurley, Emily S., primary, Hossain, M. Jahangir, additional, Montgomery, Susan P., additional, Petersen, Lyle R., additional, Sejvar, James J., additional, Mayer, Leonard W., additional, Whitney, Anne, additional, Dull, Peter, additional, Nahar, Nazmun, additional, Uddin, A. K. M. Rafique, additional, Rahman, M. Ekhlasur, additional, Ekram, A. R. M. Saifuddin, additional, Luby, Stephen P., additional, and Breiman, Robert F., additional

Published
2009
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93. Sequence Diversity of the Factor H Binding Protein Vaccine Candidate in Epidemiologically Relevant Strains of Serogroup BNeisseria meningitidis

Author

Murphy, Ellen, primary, Andrew, Lubomira, additional, Lee, Kwok‐Leung, additional, Dilts, Deborah A., additional, Nunez, Lorna, additional, Fink, Pamela S., additional, Ambrose, Karita, additional, Borrow, Ray, additional, Findlow, Jamie, additional, Taha, Muhamed‐Kheir, additional, Deghmane, Ala‐Eddine, additional, Kriz, Paula, additional, Musilek, Martin, additional, Kalmusova, Jitka, additional, Caugant, Dominique A., additional, Alvestad, Torill, additional, Mayer, Leonard W., additional, Sacchi, Claudio T., additional, Wang, Xin, additional, Martin, Diana, additional, von Gottberg, Anne, additional, du Plessis, Mignon, additional, Klugman, Keith P., additional, Anderson, Annaliesa S., additional, Jansen, Kathrin U., additional, Zlotnick, Gary W., additional, and Hoiseth, Susan K., additional

Published
2009
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96. Molecular Epidemiology of Neisseria meningitidis Isolates from an Outbreak of Meningococcal Disease among Men Who Have Sex with Men, Chicago, Illinois, 2003

Author

Schmink, Susanna, primary, Watson, John T., additional, Coulson, Garry B., additional, Jones, Roderick C., additional, Diaz, Pamela S., additional, Mayer, Leonard W., additional, Wilkins, Patricia P., additional, Messonnier, Nancy, additional, Gerber, Susan I., additional, and Fischer, Marc, additional

Published
2007
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97. Evaluation and Improvement of Real-Time PCR Assays Targeting lytA , ply , and psaA Genes for Detection of Pneumococcal DNA

Author

Carvalho, Maria da Gloria S., primary, Tondella, Maria Lucia, additional, McCaustland, Karen, additional, Weidlich, Luciana, additional, McGee, Lesley, additional, Mayer, Leonard W., additional, Steigerwalt, Arnold, additional, Whaley, Melissa, additional, Facklam, Richard R., additional, Fields, Barry, additional, Carlone, George, additional, Ades, Edwin W., additional, Dagan, Ron, additional, and Sampson, Jacquelyn S., additional

Published
2007
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98. Changes in the Population Structure of Invasive Neisseria meningitidis in the United States After Quadrivalent Meningococcal Conjugate Vaccine Licensure.

Author

Xin Wang, Shutt, Kathleen A., Vuong, Jeni T., Cohn, Amanda, MacNeil, Jessica, Schmink, Susanna, Plikaytis, Brian, Messonnier, Nancy E., Harrison, Lee H., Clark, Thomas A., and Mayer, Leonard W.

Subjects
NEISSERIA meningitidis, MENINGOCOCCAL vaccines, MOLECULAR epidemiology, HORIZONTAL gene transfer, VACCINE effectiveness, THERAPEUTICS
Abstract

Background. Meningococcal conjugate vaccines against serogroups A, C, W, and Y (MenACWY) are recommended for routine use in adolescents aged 11-18 years. The impact of these vaccines on the meningococcal population structure in the United States have yet to be evaluated. Methods. Meningococcal isolates recovered during 2006-2010 (ie, after introduction of MenACWY) collected through Active Bacterial Core surveillance (ABCs) were characterized; serogroup distribution and molecular features of these isolates were compared to previously published data on ABCs isolates recovered from 2000 to 2005 (ie, before introduction of MenACWY). P values were generated using χ2 statistics and exact methods. Results. There was a significant change (P < .05) in serogroup distribution among all age groups between the 2 periods. A small proportion of isolates showed evidence of capsular switching in both periods. Between the 2 periods, significant changes were observed in the distribution of porin A, ferric enterobactin transport, and strain genotypes among vaccine and nonvaccine serogroups. Conclusions. The population structure of US meningococcal isolates is dynamic; some changes occurred over time, but the basic structure remained. Vaccine-induced serogroup replacement was not observed, although a small proportion of isolates had undergone capsule switching, possibly driven by non-vaccine-mediated selection. Changes in the distribution of molecular features are likely due to horizontal gene transfer and changes in serogroup distribution. [ABSTRACT FROM AUTHOR]

Published
2015
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