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52. Effects of in‐hospital exercise on sarcopenia in hepatoma patients who underwent transcatheter arterial chemoembolization

Author

Koya, Shunji, primary, Kawaguchi, Takumi, additional, Hashida, Ryuki, additional, Hirota, Keisuke, additional, Bekki, Masafumi, additional, Goto, Emiko, additional, Yamada, Maiko, additional, Sugimoto, Masako, additional, Hayashi, Saki, additional, Goshima, Norihiro, additional, Yoshiyama, Teruhito, additional, Otsuka, Takashi, additional, Nozoe, Ryosuke, additional, Nagamatsu, Ayu, additional, Nakano, Dan, additional, Shirono, Tomotake, additional, Shimose, Shigeo, additional, Iwamoto, Hideki, additional, Niizeki, Takashi, additional, Matsuse, Hiroo, additional, Koga, Hironori, additional, Miura, Hiroko, additional, Shiba, Naoto, additional, and Torimura, Takuji, additional

Published
2018
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53. Patient‐reported outcomes in patients with non‐alcoholic fatty liver disease: A narrative review of Chronic Liver Disease Questionnaire‐non‐alcoholic fatty liver disease/non‐alcoholic steatohepatitis.

Author

Yamamura, Sakura, Nakano, Dan, Hashida, Ryuki, Tsutsumi, Tsubasa, Kawaguchi, Takumi, Okada, Michiaki, Isoda, Hiroshi, Takahashi, Hirokazu, Matsuse, Hiroo, Eguchi, Yuichiro, Sumida, Yoshio, Nakajima, Atsushi, Gerber, Lynn, Younossi, Zobair M, and Torimura, Takuji

Subjects
NON-alcoholic fatty liver disease, PATIENT reported outcome measures, HEPATIC fibrosis, SYMPTOMS, LIVER diseases, CHRONIC diseases
Abstract

Non‐alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and one of the leading causes of hepatocellular carcinoma and liver transplantation. Moreover, patients with NAFLD frequently complain of non‐specific symptoms including fatigue, abdominal discomfort, as well as anxiety, and NAFLD is reported to affect patient‐reported outcomes (PROs). Thus, for clarifying the total burden of NAFLD, it is crucial to assess all associated outcomes, including not only clinical and economic outcomes but also PROs. PROs are thought to reflect what is happening in one's daily life and is an important way patients and health‐care professionals communicate. There are various instruments for the assessment of PROs. Recently, a NAFLD/non‐alcoholic steatohepatitis (NASH)‐specific instrument called "Chronic Liver Disease Questionnaire (CLDQ)‐NAFLD/NASH" has been developed. CLDQ‐NAFLD/NASH comprises six domains: (i) abdominal symptoms, (ii) activity/energy, (iii) emotional health, (iv) fatigue, (v) systemic symptoms, and (vi) worry. CLDQ‐NAFLD/NASH has demonstrated excellent internal consistency, face validity, content validity, and test–retest reliability. It has been sufficiently validated in two international phase 3 clinical trials. In this review, we summarize features of various instruments for assessing PROs by focusing on CLDQ‐NAFLD/NASH. We also examine the validity of CLDQ‐NAFLD/NASH in Japanese patients and alterations in CLDQ‐NAFLD/NASH score in Japanese patients with significant hepatic fibrosis. Moreover, we discuss the utility of CLDQ‐NAFLD/NASH in phase 3 clinical trials and in a real‐world clinical setting. [ABSTRACT FROM AUTHOR]

Published
2021
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54. Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma.

Author

Hirota, Keisuke, Kawaguchi, Takumi, Koya, Shunji, Nagamatsu, Ayu, Tomita, Manabu, Hashida, Ryuki, Nakano, Dan, Niizeki, Takashi, Matsuse, Hiroo, Shiba, Naoto, and Torimura, Takuji

Subjects
CHRONICALLY ill, HEPATOCELLULAR carcinoma, ATROPHY, RECEIVER operating characteristic curves, MUSCLE mass
Abstract

Aim: Muscle atrophy is a prognostic factor for patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). The Liver Frailty Index (LFI) is a simple physical function test; however, an association between LFI and muscle mass remains unclear. We aimed to investigate the utility of LFI for predicting muscle atrophy in CLD patients with HCC. Methods: We enrolled 138 CLD patients with HCC (aged 77 years, female/male 34.8%/65.2%). Muscle mass was assessed by skeletal muscle index, and patients were classified into the muscle atrophy group (n = 109) or the non‐muscle atrophy group (n = 29). Physical frailty was assessed by LFI. The optimal cut‐off value of LFI for predicting muscle atrophy was identified by receiver operating characteristic analysis. Results: In the muscle atrophy group, the prevalence of pre‐frail/frail was significantly higher than the non‐muscle atrophy group (87.2% vs. 58.6%, P = 0.0005). In the logistic regression analysis, being female and pre‐frail/frail were identified as independent factors associated with muscle atrophy (pre‐frail/frail; OR 3.601, 95% CI 1.381–9.400, P = 0.0088). In patients with normal grip strength, 71.1% of patients were pre‐frail/frail, in which 82.8% of patients showed muscle atrophy. Receiver operating characteristic statistics provided an area under the curve of 0.74, and an LFI cut‐off value of 2.94 for predicting muscle atrophy (sensitivity 88.06%, specificity 52.17%, accuracy 77.91%). Conclusions: We showed that pre‐frail/frail was an independent factor for muscle atrophy in CLD patients with HCC. Furthermore, LFI predicted muscle atrophy with high sensitivity, even in patients with normal grip strength. Thus, LFI might be a useful screening tool for muscle atrophy in CLD patients with HCC. [ABSTRACT FROM AUTHOR]

Published
2020
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55. The Effect of Neuromuscular Electrical Stimulation During Walking on Muscle Strength and Knee Pain in Obese Women With Knee Pain: A Randomized Controlled Trial.

Author

Matsuse, Hiroo, Segal, Neil A., Rabe, Kaitlin G., and Shiba, Naoto

Subjects
*COMPARATIVE studies, *ELECTRIC stimulation, *EXERCISE tests, *MUSCLE strength, *OBESITY, *QUALITY of life, *QUESTIONNAIRES, *REGRESSION analysis, *RESEARCH funding, *T-test (Statistics), *WALKING, *WOMEN'S health, *RANDOMIZED controlled trials, *TREATMENT effectiveness, *PRE-tests & post-tests, *BLIND experiment, *KNEE pain
Abstract

Supplemental digital content is available in the text. Objective: The aim of the study was to assess the effectiveness of a hybrid training system with walking that simultaneously applies electrical stimulation to the knee extensors/flexors during walking in obese women with knee pain. Design: This is a randomized, single-blind (assessor), controlled trial. Twenty-eight obese women with knee pain were randomized to 12 weeks of biweekly walking with either hybrid training system with walking or with transcutaneous electrical nerve stimulation (control). Primary outcomes (maximum isokinetic knee extensor torque and maximum isokinetic knee flexor torque) and secondary outcomes (20-m walk time, chair-stand time, stair-climb time, knee pain, and knee-related quality life) were evaluated. Change-point regression analyses were used to model the interaction for the primary outcomes. Two-sample t tests were used on pre-post change scores in secondary outcomes. Results: Knee extensor torque increased significantly more in the hybrid training system with walking group than the control group when baseline knee extensor torque was greater than 57.2 Nm (P = 0.0033). When baseline knee flexor torque was at 30 or 50 Nm, there was a trend toward greater increase in the hybrid training system with walking group than the control group (P = 0.0566, P = 0.0737, respectively). There were no significant differences between groups in secondary outcomes. Conclusions: These results suggest that hybrid training system with walking is effective for improving knee extensor torque in obese women with knee pain. However, the superiority of hybrid training system with walking may vary depending on baseline knee muscle strength. [ABSTRACT FROM AUTHOR]

Published
2020
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61. The association between sarcopenia and decorin, an exercise-induced myokine, in patients with liver cirrhosis: a pilot study

Author

Bekki, Masafumi, primary, Hashida, Ryuki, additional, Kawaguchi, Takumi, additional, Goshima, Norihiro, additional, Yoshiyama, Teruhito, additional, Otsuka, Takashi, additional, Koya, Shunji, additional, Hirota, Keisuke, additional, Matsuse, Hiroo, additional, Niizeki, Takashi, additional, Torimura, Takuji, additional, and Shiba, Naoto, additional

Published
2018
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62. Profiles Associated with Sarcopenia in Hepatoma Patients Underwent Transcatheter Arterial Chemoembolization: A Data‐Mining Analysis

Author

Hirota, Keisuke, primary, Kawaguchi, Takumi, additional, Hashida, Ryuki, additional, Koya, Shunji, additional, Bekki, Masafumi, additional, Goshima, Norihiro, additional, Yoshiyama, Teruhito, additional, Otsuka, Takashi, additional, Nozoe, Ryosuke, additional, Nakano, Dan, additional, Shirono, Tomotake, additional, Shimose, Shigeo, additional, Iwamoto, Hideki, additional, Niizeki, Takashi, additional, Matsuse, Hiroo, additional, Koga, Hironori, additional, Shiba, Naoto, additional, and Torimura, Takuji, additional

Published
2018
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63. Evaluation of Motor-Assisted Gloves (SEM Glove) for Patients with Functional Finger Disorders: A Clinical Pilot Study

Author

HASHIDA, RYUKI, primary, MATSUSE, HIROO, additional, BEKKI, MASAFUMI, additional, OMOTO, MASAYUKI, additional, MORIMOTO, SHIMPEI, additional, HINO, TOMOKO, additional, HARANO, YUUJI, additional, IWASA, CHIKAHIRO, additional, MIYAMOTO, KAZUKI, additional, HARAGUCHI, MASAKUNI, additional, NAGO, TAKESHI, additional, and SHIBA, NAOTO, additional

Published
2018
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65. Cardiac cycle-synchronized electrical muscle stimulator for lower limb training with the potential to reduce the heart's pumping workload

Author

Sasaki, Ken-ichiro, primary, Matsuse, Hiroo, additional, Akimoto, Ryuji, additional, Kamiya, Shiro, additional, Moritani, Toshio, additional, Sasaki, Motoki, additional, Ishizaki, Yuta, additional, Ohtsuka, Masanori, additional, Nakayoshi, Takaharu, additional, Ueno, Takafumi, additional, Shiba, Naoto, additional, and Fukumoto, Yoshihiro, additional

Published
2017
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71. Effects of in‐hospital exercise on sarcopenia in hepatoma patients who underwent transcatheter arterial chemoembolization.

Author

Koya, Shunji, Kawaguchi, Takumi, Hashida, Ryuki, Hirota, Keisuke, Bekki, Masafumi, Goto, Emiko, Yamada, Maiko, Sugimoto, Masako, Hayashi, Saki, Goshima, Norihiro, Yoshiyama, Teruhito, Otsuka, Takashi, Nozoe, Ryosuke, Nagamatsu, Ayu, Nakano, Dan, Shirono, Tomotake, Shimose, Shigeo, Iwamoto, Hideki, Niizeki, Takashi, and Matsuse, Hiroo

Subjects
CHEMOEMBOLIZATION, EXERCISE
Abstract

Background and Aim: Sarcopenia is a prognostic factor in hepatocellular carcinoma (HCC) patients. HCC patients who underwent transcatheter arterial chemoembolization (TACE) are at a risk of muscle atrophy. We aimed to investigate the effects of in‐hospital exercise on muscle mass and factors associated with muscle hypertrophy in HCC patients who underwent TACE. Methods: We enrolled 209 HCC patients who underwent TACE. Patients were classified into either an exercise (n = 102) or control (n = 107) group. In the exercise group, patients were treated with in‐hospital exercise (median 2.5 metabolic equivalents/20–40 min/day). The effects of exercise on muscle mass were evaluated by changes in skeletal muscle index (ΔSMI) between before and after TACE. Factors associated with an increase in SMI were analyzed by logistic regression and decision‐tree analyses. Results: There was no significant difference in serum albumin and bilirubin levels between the two groups. ΔSMI was significantly higher in the exercise group than in the control group (0.28 cm2/m2vs −1.11 cm2/m2, P = 0.0029). In the logistic regression analysis, exercise was an independent factor for an increase in SMI (hazard ratio 2.13; 95% confidence interval 1.215–3.846; P = 0.0085). Moreover, the decision‐tree analysis showed that exercise was the initial divergence variable for an increase in SMI (the ratio of increased SMI: 53% in the exercise group vs 36% in the control group). Conclusions: In‐hospital exercises increased muscle mass in HCC patients who underwent TACE. In addition, exercise was an independent factor for muscle hypertrophy. Thus, in‐hospital exercise may prevent sarcopenia in HCC patients who underwent TACE. [ABSTRACT FROM AUTHOR]

Published
2019
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72. Study of the development of the effective device for maintaining the skeletal muscle in the space

Author

Shiba, Naoto, Matsuse, Hiroo, Nago, Takeshi, Umezu, Yuichi, and Tagawa, Yoshihiko

Subjects
analysis of variance, muscle, 関節運動, 身体的訓練, antagonist muscle, joint movement, 分散分析, 筋肉, atrophy, physical exercise, ハイブリッド訓練, 無重力, 電気刺激, electric stimulus, 拮抗筋, biceps muscle of arm, hybrid exercise, 萎縮, 上腕二頭筋, weightlessness
Abstract

A 'hybrid exercise' technique that uses the force generated by an electrically stimulated antagonist muscle to provide resistance to a volitionally contracting agonist was developed. In other words, the agonist performs a volitional concentric contraction against an electrically stimulated eccentric contraction of the antagonist. Hybrid exercise has several advantages. These include; 1) activation of type 1 muscle fiber as a result of the volitional contraction of agonist muscles, 2) simultaneous exercise both agonist and antagonist musculature, 3) longitudinal bone force loads, 4) requiring minimal external stabilization of the subjects, and 5) the proven safety of the electrical stimulation as a physical therapy modality. Hybrid exercise, which utilizes electrically stimulated antagonist force as a resistance of joint motion instead of the gravity, would become a useful exercise method in the weightlessness environment., 資料番号: AA0048095054

Published
2005

75. Effects of in-hospital exercise on liver function, physical ability, and muscle mass during treatment of hepatoma in patients with chronic liver disease

Author

Koya, Shunji, primary, Kawaguchi, Takumi, additional, Hashida, Ryuki, additional, Goto, Emiko, additional, Matsuse, Hiroo, additional, Saito, Hiromichi, additional, Hirota, Keisuke, additional, Taira, Ryoko, additional, Matsushita, Yoshiko, additional, Imanaga, Minami, additional, Nagamatsu, Ayu, additional, Shirono, Tomotake, additional, Shimose, Shigeo, additional, Iwamoto, Hideki, additional, Niizeki, Takashi, additional, Kuromatsu, Ryoko, additional, Miura, Hiroko, additional, Shiba, Naoto, additional, and Torimura, Takuji, additional

Published
2016
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78. Correction: Electrically Stimulated Antagonist Muscle Contraction Increased Muscle Mass and Bone Mineral Density of One Astronaut - Initial Verification on the International Space Station

Author

Shiba, Naoto, primary, Matsuse, Hiroo, additional, Takano, Yoshio, additional, Yoshimitsu, Kazuhiro, additional, Omoto, Masayuki, additional, Hashida, Ryuki, additional, Tagawa, Yoshihiko, additional, Inada, Tomohisa, additional, Yamada, Shin, additional, and Ohshima, Hiroshi, additional

Published
2015
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79. Electrically Stimulated Antagonist Muscle Contraction Increased Muscle Mass and Bone Mineral Density of One Astronaut - Initial Verification on the International Space Station

Author

Shiba, Naoto, primary, Matsuse, Hiroo, additional, Takano, Yoshio, additional, Yoshimitsu, Kazuhiro, additional, Omoto, Masayuki, additional, Hashida, Ryuki, additional, Tagawa, Yoshihiko, additional, Inada, Tomohisa, additional, Yamada, Shin, additional, and Ohshima, Hiroshi, additional

Published
2015
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81. Study of Effective Device to Maintain Musculoskeletal System in Space

Author

Shiba, Naoto, Matsuse, Hiroo, Nago, Takeshi, Maeda, Takashi, Umezu, Yuichi, and Tagawa, Yoshihiko

Subjects
disuse atrophy, musculoskeletal system, countermeasure
Abstract

第22回宇宙利用シンポジウム(2006年1月17日-19日, 日本学術会議6階会議室 六本木、東京), The Twenty-second Space Utilization Symposium (January 17-19, 2006: Science Council of Japan, Roppongi, Tokyo, Japan), We have developed "hybrid exercise"that is designed to strengthen and maintain the muscles by using electrically stimulated antagonist muscles to resist volitional contraction of agonist muscles as they move through their range of motion. This approach produces a minimum of inertial reaction forces and has the advantage that it may minimize the need for external stabilization that is currently necessary during exercise in a weightlessness environment., 共催: 日本学術会議, Meeting sponsors: The Science Council of Japan, The Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA), 資料番号: AA0064113061

Published
2006

100. Effects of Cognitive Task During Unstable Walking on the Frontal Cerebral Blood Flow in Elderly Retirement Home Residents Leading an Independent Daily Life.

Author

Hashiguchi S, Matsuse H, Ito K, Kamura C, and Takano Y

Abstract

Objectives: This study aimed to examine the effects of cognitive tasks during walking with perturbation on the cerebral blood flow., Methods: The subjects were a total of 20 persons, consisting of 12 healthy adults aged 21-47 years (adult group) and 8 retirement home residents aged 67-85 years who led an independent daily life and could walk independently (elderly group). Oxyhemoglobin was measured using wireless functional near-infrared spectroscopy (fNIRS). An analysis was conducted using the Wilcoxon rank sum test to compare the variation of oxyhemoglobin between walking with perturbation (WP) and walking with perturbation and cognitive tasks (WPC) in each group. In addition, we compared the variation of oxyhemoglobin between groups by analysis of covariance adjusting for the value of WP., Results: In the adult group, the left and right oxyhemoglobin significantly increased under WPC (p=0.0122, 0.0015, respectively). On the other hand, in the elderly group, the right and left oxyhemoglobin did not significantly change under WPC., Conclusions: These results suggest that the effect of a cognitive task during unstable walking conditions differs between healthy adults and elderly persons, and that this may be important when considering postural control strategies, especially in the elderly.

Published
2024
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