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53. Preparation of Pt–Ru Alloyed Thin Films Using a Single-Source CVD Precursor<FNR HREF="fn1"></FNR><FN ID="fn1">We thank the National Sciences Council of Taiwan (NSC 90-2113-M-007-056) and the National Research Council Canada for support of the work.</FN>

Author

Huang, S.-F., Chi, Y., Liu, C.-S., Carty, A.J., Mast, K., Bock, C., MacDougall, B., Peng, S.-M., and Lee, G.-H.

Abstract

Treatment of (dimethylaminomethyl)ruthenocene with cis-Pt(DMSO)2Cl2 led to the formation of a ruthenocenyl platinum complex [CpRu(η5-C5H3CH2NMe2)Pt(DMSO)Cl] (1); subsequent treatment of 1 with [Na(hfac)] afforded an air-stable Pt–Ru complex [CpRu(η5-C5H3CH2NMe2)Pt(hfac)] (2). Its volatility and other physical data relevant to CVD experiments were assessed by thermogravimetric analysis (TGA). The Pt–Ru thin films were then deposited at two deposition temperatures, 300 °C and 400 °C, using O2 as the reactive carrier gas. The as-deposited thin films were characterized using energy dispersive X-ray (EDX), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). Results indicated the formation of a homogeneous Pt–Ru solid solution at the lower deposition temperature. However, upon raising the temperature to 400 °C, phase separation between Pt and Ru occurred, which then induced the growth of RuO2 grains at the substrate surface and caused depletion of the alloy in ruthenium. The electrocatalytic activities of the films, in respect of methanol oxidation, were investigated, in half-cell experiments, by cyclic voltammetry.

Published
2003
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56. (PhAs)6und (tBuAs)4als Edukte für Komplexe mit einem acyclischen As3sowie einem tBu7As9‐Liganden

Author

Mast, K., Scherer, O. J., and Wolmershäuser, G.

Abstract

Die Cothermolyse von [Cp″Ta(CO)4] (1) (Cp″ = C5H3But2‐1,3) und (PhAs)6(2) ergibt den Tantal‐Dreikerncluster [{Cp″Ta}3(μ‐O)2(μ3‐CPh)(As3)] (3) mit einem Ta3As3‐Gerüst aus drei stark verzerrten Tetraedern mit zwei gemeinsamen Flächen. (RAs)4(6) reagiert bei Raumtemperatur mit [Fe2(CO)9] (7) zu [(R7As9){Fe(CO)4}] (8), R = tBu, dessen neuer R7As9‐Ligand aus zwei Arsen‐Vierringen besteht, die durch eine RAs‐Brücke verbunden sind.

Published
1999
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59. The ASDEX Integrated Data Analysis System AIDA

Author

Graßie, K., Gruber, O., Kardaun, O., Kaufmann, M., Lackner, K., Martin, P., Mast, K.-F., McCarthy, P. J., Mertens, V., Pohl, D., Rang, U., Wunderlich, R., and ASDEX Team

Published
1989

60. Pellet Injection with Improved Confinement in ASDEX

Author

Mertens, V., Kaufmann, M., Büchl, K., Fußmann, G., Gehre, O., Graßie, K., Gruber, O., Haas, G., Janeschitz, G., Kornherr, M., Lackner, K., Lang, R., Mast, K., McCormick, K., Neuhauser, J., Niedermeyer, H., Sandmann, W., Zasche, D., Zehrfeld, H., and Pietrzyk, Z.

Published
1987

61. Evolution of radiation power profiles in ASDEX h-mode discharges

Author

Mueller, E., Janeschitz, G., Smeulders, P., Fußmann, G., Kornherr, M., Mast, K., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Karger, F., Keilhacker, M., Klüber, O., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Murmann, H., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Söldner, F., Speth, E., Steuer, K., Vollmer, O., Wagner, F., and Zasche, D.

Published
1986

63. Radiation behaviour of gas and pellet refuelled high density discharges in ASDEX

Author

Mast, K., Müller, E., Fahrbach, H., Krause, H., Lang, R., McCarthy, P., Sandmann, W., Zasche, D., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Söldner, F., Steinmetz, K., Steuer, K., Ugniewski, S., Vollmer, O., and Wagner, F.

Published
1987

64. ASDEX Contributions to the 14th European Conference on Controlled Fusion and Plasma Physics. Madrid, June 22-26, 1987

Author

Mertens, V., Mast, K. F., Kornherr, M., Feneberg, W., Steinmetz, K., Noterdaeme, J.-M., Behrisch, R., van Nieuwenhove, R., Söldner, F. X., Speth, E., Gruber, O., Dodel, G., Riedel, K. S., Wagner, F., Fussmann, G., Gehre, O., Zasche, D., Becker, G., McCarthy, P. J., Zehrfeld, H. P., Lisitano, G., McCormick, K., Tsois, N., Hübner, K., and Robouch, B. V.

Published
1987

68. Neoclassical Impurity Transport in Ohmically Heated Pellet Discharges

Author

Feneberg, W., Mast, K., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Söldner, F., Steinmetz, K., Steuer, K., Tsois, N., Ugniewski, S., Vollmer, O., Wagner, F., and Zasche, D.

Published
1987

69. Bolometric diagnostics in JET.

Author

Mast, K. F., Krause, H., Behringer, K., Bulliard, A., and Magyar, G.

Subjects
*RADIATION measurements, *JETS (Fluid dynamics), *CAMERAS, *BOLOMETERS
Abstract

Radiation losses from the JET plasma are measured (temporally and spatially resolved) with three pin-hole cameras which observe one poloidal plasma cross section from underneath (one vertical camera with 14 bolometers) and from the side (two horizontal cameras with 10 bolometers each). In addition, eight collimated single bolometers monitor toroidal symmetry of plasma emissivity. An improved metal resistor bolometer capable of surviving at least 5000 D-T pulses in JET is composed of two identical foils (4-µm-thick gold absorber, 7.5-µm-thick Kapton substrate, and 0.1-µm-thick gold resistor), mounted one behind another in one housing. The rear foil serves as a reference bolometer in a bridge circuit. With an integration time constant of 20 ms a detection limit of 70 µW/cm² was measured in JET. Examples of measuring results in JET are presented: strong poloidal asymmetries of the radiation density as precursor signals of a density limit disruption and the formation of a poloidally symmetric, cold plasma mantle before a disruption. [ABSTRACT FROM AUTHOR]

Published
1985
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70. Observation of continuous divertor detachment in H-mode discharges in ASDEX Upgrade

Author

Gruber, O., Kallenbach, A., Kaufmann, M., Lackner, K., Mertens, V., Neuhauser, J., Ryter, F., Zohm, H., Bessenrodt-Weberpals, M., Büchl, K., Fiedler, S., Field, A., Fuchs, Ch, Garcia-Rosales, C., Haas, G., Herrmann, A., Herrmann, W., Hirsch, S., Köppendörfer, W., Lang, P., Lieder, G., Mast, K. -F, Pitcher, C. S., Schittenhelm, M., Stober, J., Suttrop, W., Troppmann, M., Weinlich, M., Albrecht, M., Alexander, M., Asmussen, K., Ballico, M., Behler, K., Behringer, K., Bosch, H. S., Brambilla, M., Carlson, A., Coster, D., Cupido, L., Deblank, H. J., Pena Hempel, S., Deschka, S., Dorn, C., Drube, R., Dux, R., Eberhagen, A., Engelhardt, W., Fahrbach, H. -U, Feist, H. -U, Fieg, D., Fußmann, G., Gehre, O., Gernhardt, J., Ignacz, P., Jüttner, B., Junker, W., Kass, T., Kiemer, K., Kollotzek, H., Kornherr, M., Krieger, K., Kurzan, B., Lang, R., Laux, M., Maria Manso, Maraschek, M., Mayer, H. -M, Mccarthy, P., Meisel, D., Merkel, R., Murmann, H., Napiontek, B., Naujoks, D., Neu, G., Neu, R., Noterdaeme, J. -M, Pautasso, G., Poschenrieder, W., Raupp, G., Richter, H., Richter, T., Röhr, H., Roth, J., Salmon, N., Salzmann, H., Sandmann, W., Schilling, H. -B, Schneider, H., Schneider, R., Schneider, W., Schönmann, K., Schramm, G., Schumacher, U., Schweinzer, J., Seidel, U., Serra, F., Silva, A., Sokoll, M., and Speth, E.

72. Preliminary ICRF results from JET

Author

Jacquinot, J, primary, Anderson, R, additional, Arbez, J, additional, Bartlett, D, additional, Beaumont, B, additional, Behringer, K, additional, Bertolini, E, additional, Bosia, G, additional, Brinkschulte, H, additional, Bures, M, additional, Campbell, D, additional, Christiansen, K, additional, Christodoulopoulos, C, additional, Claesen, R, additional, Cordey, J, additional, Corti, S, additional, Costley, A, additional, Cottrell, G, additional, Denne, B, additional, Evrard, M, additional, Gambier, D, additional, Green, B, additional, Grosso, G, additional, Huguet, M, additional, Jarvis, O N, additional, Kaye, A, additional, Kimura, H, additional, Krause, H, additional, Lallia, P P, additional, Lomas, P, additional, Magyar, G, additional, Mansfield, M, additional, Mast, K, additional, Mondino, P L, additional, Morgan, P, additional, Plancoulaine, J, additional, O'Rourke, J, additional, Rebut, P H, additional, Sadler, G, additional, Sand, F, additional, Schmid, M, additional, Segre, S, additional, Sibley, A, additional, Stamp, M, additional, Summers, D, additional, Thomsen, K, additional, Tanga, A, additional, Valisa, M, additional, Wade, T, additional, and Walker, C, additional

Published
1985
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73. Tungsten as target material in fusion devices.

Author

Naujoks, D., Asmussen, K., Bessenrodt-Weberpals, M., Deschka, S., Dux, R., Engelhardt, W., Field, A. R., Fussmann, G., Fuchs, J. C., Garcia-Rosales, C., Hirsch, S., Ignacz, P., Lieder, G., Mast, K. F., Neu, R., Radtke, R., Roth, J., and Wenzel, U.

Published
1996
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74. Disruptions in JET.

Author

Wesson, J. A., Gill, R. D., Hugon, M., Schüller, F. C., Snipes, J. A., Ward, D. J., Bartlett, D. V., Campbell, D. J., Duperrex, P. A., Edwards, A. W., Granetz, R. S., Gottardi, N. A. O., Hender, T. C., Lazzaro, E., Lomas, P. J., Lopes Cardozo, N., Mast, K. F., Nave, M. F. F., Salmon, N. A., and Smeulders, P.

Published
1989
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75. Pellet injection with improved confinement in ASDEX.

Author

Kaufmann, M., Büchl, K., Fussmann, G., Gehre, O., Grassie, K., Gruber, O., Haas, G., Janeschitz, G., Kornherr, M., Lackner, K., Lang, R. S., Mast, K. F., McCormick, K., Mertens, V., Neuhauser, J., Niedermeyer, H., Sandmann, W., Schneider, W., Zasche, D., and Zehrfeld, H. -P

Published
1988
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76. Overview of ASDEX Upgrade results

Author

Kallenbach, A., Aguiam, D., Aho-Mantila, L., Angioni, C., Arden, N., Parra, R. Arredondo, Asunta, O., Baar, M., Balden, M., Behler, K., Bergmann, A., Bernardo, J., Bernert, M., Beurskens, M., Biancalani, A., Bilato, R., Birkenmeier, G., Bobkov, V., Bock, A., Bogomolov, A., Bolzonella, T., Boswirth, B., Bottereau, C., Bottino, A., Brand, H., Brezinsek, S., Brida, D., Brochard, F., Bruhn, C., Buchanan, J., Buhler, A., Burckhart, A., Cambon-Silva, D., Camenen, Y., Carvalho, P., Carrasco, G., Cazzaniga, C., Carr, M., Carralero, D., Casali, L., Castaldo, C., Cavedon, M., Challis, C., Chankin, A., Chapman, I., Clairet, F., Classen, I., Coda, S., Coelho, R., Coenen, J. W., Colas, L., Conway, G., Costea, S., Coster, D. P., Croci, G., Cseh, G., Czarnecka, A., D Arcangelo, O., Day, C., Delogu, R., Marne, P., Denk, S., Denner, P., Dibon, M., D Inca, R., Di Siena, A., Douai, D., Drenik, A., Drube, R., Dunne, M., Duval, B. P., Dux, R., Eich, T., Elgeti, S., Engelhardt, K., Erdos, B., Erofeev, I., Esposito, B., Fable, E., Faitsch, M., Fantz, U., Faugel, H., Felici, F., Fietz, S., Figueredo, A., Fischer, R., Ford, O., Frassinetti, L., Freethy, S., Froschle, M., Fuchert, G., Fuchs, J. C., Funfgelder, H., Galazka, K., Galdon-Quiroga, J., Gallo, A., Gao, Y., Garavaglia, S., Garcia-Munoz, M., Geiger, B., Cianfarani, C., Giannone, L., Giovannozzi, E., Gleason-Gonzalez, C., Gloggler, S., Gobbin, M., Gorler, T., Goodman, T., Gorini, G., Gradic, D., Grater, A., Granucci, G., Greuner, H., Griener, M., Groth, M., Gude, A., Gunter, S., Guimarais, L., Haas, G., Hakola, A. H., Ham, C., Happel, T., Harrison, J., Hatch, D., Hauer, V., Hayward, T., Heinemann, B., Heinzel, S., Hellsten, T., Henderson, S., Hennequin, P., Herrmann, A., Heyn, E., Hitzler, F., Hobirk, J., Holzl, M., Hoschen, T., Holm, J. H., Hopf, C., Hoppe, F., Horvath, L., Houben, A., Huber, A., Igochine, V., Ilkei, T., Ivanova-Stanik, I., Jacob, W., Jacobsen, A. S., Jacquot, J., Janky, F., Jardin, A., Jaulmes, F., Jenko, F., Jensen, T., Joffrin, E., Kasemann, C., Kalvin, S., Kantor, M., Kappatou, A., Kardaun, O., Karhunen, J., Kasilov, S., Kernbichler, W., Kim, D., Kimmig, S., Kirk, A., Klingshirn, H. -J, Koch, F., Kocsis, G., Kohn, A., Kraus, M., Krieger, K., Krivska, A., Kramer-Flecken, A., Kurki-Suonio, T., Kurzan, B., Lackner, K., Laggner, F., Lang, P. T., Lauber, P., Lazanyi, N., Lazaros, A., Lebschy, A., Li, L., Li, M., Liang, Y., Lipschultz, B., Liu, Y., Lohs, A., Luhmann, N. C., Lunt, T., Lyssoivan, A., Madsen, J., Maier, H., Maj, O., Mailloux, J., Maljaars, E., Manas, P., Mancini, A., Manhard, A., Manso, M. -E, Mantica, P., Mantsinen, M., Manz, P., Maraschek, M., Martens, C., Martin Oberkofler, Marrelli, L., Martitsch, A., Mastrostefano, S., Mayer, A., Mayer, M., Mazon, D., Mccarthy, P. J., Mcdermott, R., Meisl, G., Meister, H., Medvedeva, A., Merkel, P., Merkel, R., Merle, A., Mertens, V., Meshcheriakov, D., Meyer, H., Meyer, O., Miettunen, J., Milanesio, D., Mink, F., Mlynek, A., Monaco, F., Moon, C., Nazikian, R., Nemes-Czopf, A., Neu, G., Neu, R., Nielsen, A. H., Nielsen, S. K., Nikolaeva, V., Nocente, M., Noterdaeme, J. -M, Nowak, S., Oberkofler, M., Oberparleiter, M., Ochoukov, R., Odstrcil, T., Olsen, J., Orain, F., Palermo, F., Papp, G., Perez, I. Paradela, Pautasso, G., Enzel, F., Petersson, P., Pinzon, J., Piovesan, P., Piron, C., Plaum, B., Plockl, B., Plyusnin, V., Pokol, G., Poli, E., Porte, L., Potzel, S., Prisiazhniuk, D., Putterich, T., Ramisch, M., Rapson, C., Rasmussen, J., Raupp, G., Refy, D., Reich, M., Reimold, F., Ribeiro, T., Riedl, R., Rittich, D., Rocchi, G., Rodriguez-Ramos, M., Rohde, V., Ross, A., Rott, M., Rubel, M., Ryan, D., Ryter, F., Saarelma, S., Salewski, M., Salmi, A., Sanchis-Sanchez, L., Santos, G., Santos, J., Sauter, O., Scarabosio, A., Schall, G., Schmid, K., Schmitz, O., Schneider, P. A., Schneller, M., Schrittwieser, R., Schubert, M., Schwarz-Selinger, T., Schweinzer, J., Scott, B., Sehmer, T., Sertoli, M., Shabbir, A., Shalpegin, A., Shao, L., Sharapov, S., Siccinio, M., Sieglin, B., Sigalov, A., Silva, A., Silva, C., Simon, P., Simpson, J., Snicker, A., Sommariva, C., Sozzi, C., Spolaore, M., Stejner, M., Stober, J., Stobbe, F., Stroth, U., Strumberger, E., Suarez, G., Sugiyama, K., Sun, H. -J, Suttrop, W., Szepesi, T., Tal, B., Tala, T., Tardini, G., Tardocchi, M., Terranova, D., Tierens, W., Told, D., Tudisco, O., Trevisan, G., Treutterer, W., Trier, E., Tripsky, M., Valisa, M., Valovic, M., Vanovac, B., Varela, P., Varoutis, S., Verdoolaege, G., Vezinet, D., Vianello, N., Vicente, J., Vierle, T., Viezzer, E., Toussaint, U., Wagner, D., Wang, N., Wang, X., Weidl, M., Weiland, M., White, A. E., Willensdorfer, M., Wiringer, B., Wischmeier, M., Wolf, R., Wolfrum, E., Xiang, L., Yang, Q., Yang, Z., Yu, Q., Zagorski, R., Zammuto, I., Zarzoso, D., Zhang, W., Zeeland, M., Zehetbauer, T., Zilker, M., Zoletnik, S., Zohm, H., Team, Asdex Upgrade, Team, Eurofusion Mst, Institute of Forest Botany, Georg-August-University [Göttingen], Dutch Institute for Fundamental Energy Research [Eindhoven] (DIFFER), Institute of Applied Physics (IFA - CSIC), GRIDSEN, IPFN, Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Univ Tennessee, Dept Mat Sci & Engn, The University of Tennessee [Knoxville], Technical Research Centre of Finland, VTT Technical Research Centre of Finland (VTT), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), CEA Cadarache, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Information Technology (INTEC), Universiteit Gent = Ghent University [Belgium] (UGENT), Institut für Geophysik [Clausthal-Zellerfeld], Technische Universität Clausthal (TU Clausthal), Association EURATOM-ÖAW, University of Innsbruck, Institut für Plasmaforschung [Stuttgart] (IPF), Universität Stuttgart [Stuttgart], Institute of Plasma Physics, Association Euratom/IPP.CR (IPP PRAGUE), Czech Academy of Sciences [Prague] (CAS), Department of Cancer Biology, University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS)-University of Massachusetts System (UMASS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Dipartimento di Fisica Università di Torino and INFN (DF_TORINO), Dipartimento di Fisica infi & Università di Torino, Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences des Procédés et des Matériaux (LSPM), Université Paris 13 (UP13)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), Institute for World Forestry, Johann Heinrich von Thünen Institute, Sygen International Plc, Genus Plc, Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut für Experimentelle und Angewandte Physik [Kiel] (IEAP), Christian-Albrechts-Universität zu Kiel (CAU), Department of Experimental Medical Science, AUTRES, Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Department of Obstetrics and Gynecology, Goethe-Universität Frankfurt am Main, Euratom/CCFE Fusion Association, Atomic Energy Research Institute [Budapest], Centre for Energy Research [Budapest] (MTAE), Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Chimie du CNRS (INC)-Institut National Polytechnique de Grenoble (INPG), ENEA C.R. Frascati, Via E. Fermi, 45, 00044 Frascati, Roma, Italy, affiliation inconnue, Department of Radiology, St. James's Hospital, Dept of Mechanical and Process Engineering, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Database group, Computer Science and engeenering Department [San Diego] (DB CSE UCSD), University of California [San Diego] (UC San Diego), University of California-University of California, F. Hoffmann-La RocheAG, Dutch Institute for Fundamental Energy Research [Eindhoven] ( DIFFER ), Institute of Applied Physics ( IFA - CSIC ), Instituto Superior Técnico, Universidade Técnica de Lisboa ( IST ), Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation ( IMEP-LAHC ), Centre National de la Recherche Scientifique ( CNRS ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Institut National Polytechnique de Grenoble ( INPG ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Université Grenoble Alpes ( UGA ), Institut de biologie et chimie des protéines [Lyon] ( IBCP ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), VTT Technical Research Centre of Finland ( VTT ), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung ( AWI ), Laboratoire de Science et Génie des Matériaux et de Métallurgie ( LSG2M ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Department of Information Technology ( INTEC ), Ghent University [Belgium] ( UGENT ), Institut fur Geophysical, IPF, Institute of Plasma Physics, Association Euratom/IPP.CR ( IPP PRAGUE ), Czech Academy of Sciences [Prague] ( ASCR ), University of Massachusetts Medical School [Worcester] ( UMASS ), Institut de Recherche sur la Fusion par confinement Magnétique ( IRFM ), Dipartimento di Fisica Università di Torino and INFN ( DF_TORINO ), Forschungszentrum Jülich GmbH, Institut d'Electronique du Solide et des Systèmes ( InESS ), Centre National de la Recherche Scientifique ( CNRS ), Institut Jean Lamour ( IJL ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Lorraine ( UL ), Laboratoire des Sciences des Procédés et des Matériaux ( LSPM ), Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Institut Galilée-Centre National de la Recherche Scientifique ( CNRS ), Institut de biologie moléculaire des plantes ( IBMP ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), IEAP, Christian-Albrechts-Universität zu Kiel ( CAU ), Max-Planck-Institut für Plasmaphysik [Garching] ( IPP ), J. W. Goethe-University, Hungarian Academy of Sciences KFKI Atomic Energy Research Institute, Science et Ingénierie des Matériaux et Procédés ( SIMaP ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Laboratoire de Physique Corpusculaire - Clermont-Ferrand ( LPC ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), university college cork, University College Cork ( UCC ), Eidgenössische Technische Hochschule [Zürich] ( ETH Zürich ), Database group, Computer Science and engeenering Department [San Diego] ( DB CSE UCSD ), University of California [San Diego] ( UC San Diego ), Aguiam, D, Aho-Mantila, L, Angioni, C, Arden, N, Parra, R, Asunta, O, Debaar, M, Balden, M, Behler, K, Bergmann, A, Bernardo, J, Bernert, M, Beurskens, M, Biancalani, A, Bilato, R, Birkenmeier, G, Bobkov, V, Bock, A, Bogomolov, A, Bolzonella, T, Boeswirth, B, Bottereau, C, Bottino, A, Van den Brand, H, Brezinsek, S, Brida, D, Brochard, F, Bruhn, C, Buchanan, J, Buhler, A, Burckhart, A, Cambon-Silva, D, Camenen, Y, Carvalho, P, Carrasco, G, Cazzaniga, C, Carr, M, Carralero, D, Casali, L, Castaldo, C, Cavedon, M, Challis, C, Chankin, A, Chapman, I, Clairet, F, Classen, I, Coda, S, Coelho, R, Coenen, J, Colas, L, Conway, G, Costea, S, Coster, D, Croci, G, Cseh, G, Czarnecka, A, D'Arcangelo, O, Day, C, Delogu, R, de Marne, P, Denk, S, Denner, P, Dibon, M, D'Inca, R, Disiena, A, Douai, D, Drenik, A, Drube, R, Dunne, M, Duval, B, Dux, R, Eich, T, Elgeti, S, Engelhardt, K, Erdos, B, Erofeev, I, Esposito, B, Fable, E, Faitsch, M, Fantz, U, Faugel, H, Felici, F, Fietz, S, Figueredo, A, Fischer, R, Ford, O, Frassinetti, L, Freethy, S, Froeschle, M, Fuchert, G, Fuchs, J, Fuenfgelder, H, Galazka, K, Galdon-Quiroga, J, Gallo, A, Gao, Y, Garavaglia, S, Garcia-Munoz, M, Geiger, B, Cianfarani, C, Giannone, L, Giovannozzi, E, Gleason-Gonzalez, C, Gloeggler, S, Gobbin, M, Goerler, T, Goodman, T, Gorini, G, Gradic, D, Graeter, A, Granucci, G, Greuner, H, Griener, M, Groth, M, Gude, A, Guenter, S, Guimarais, L, Haas, G, Hakola, A, Ham, C, Happel, T, Harrison, J, Hatch, D, Hauer, V, Hayward, T, Heinemann, B, Heinzel, S, Hellsten, T, Henderson, S, Hennequin, P, Herrmann, A, Heyn, E, Hitzler, F, Hobirk, J, Hoelzl, M, Hoeschen, T, Holm, J, Hopf, C, Hoppe, F, Horvath, L, Houben, A, Huber, A, Igochine, V, Ilkei, T, Ivanova-Stanik, I, Jacob, W, Jacobsen, A, Jacquot, J, Janky, F, Jardin, A, Jaulmes, F, Jenko, F, Jensen, T, Joffrin, E, Kaesemann, C, Kallenbach, A, Kalvin, S, Kantor, M, Kappatou, A, Kardaun, O, Karhunen, J, Kasilov, S, Kernbichler, W, Kim, D, Kimmig, S, Kirk, A, Klingshirn, H, Koch, F, Kocsis, G, Koehn, A, Kraus, M, Krieger, K, Krivska, A, Kraemr-Flecken, A, Kurki-Suonio, T, Kurzan, B, Lackner, K, Laggner, F, Lang, P, Lauber, P, Lazanyi, N, Lazaros, A, Lebschy, A, Li, L, Li, M, Liang, Y, Lipschultz, B, Liu, Y, Lohs, A, Luhmann, N, Lunt, T, Lyssoivan, A, Madsen, J, Maier, H, Maj, O, Mailloux, J, Maljaars, E, Manas, P, Mancini, A, Manhard, A, Manso, M, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Martens, C, Martin, P, Marrelli, L, Martitsch, A, Mastrostefano, S, Mayer, A, Mayer, M, Mazon, D, Mccarthy, P, Mcdermott, R, Meisl, G, Meister, H, Medvedeva, A, Merkel, P, Merkel, R, Merle, A, Mertens, V, Meshcheriakov, D, Meyer, H, Meyer, O, Miettunen, J, Milanesio, D, Mink, F, Mlynek, A, Monaco, F, Moon, C, Nazikian, R, Nemes-Czopf, A, Neu, G, Neu, R, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Noterdaeme, J, Nowak, S, Oberkofler, M, Oberparleiter, M, Ochoukov, R, Odstrcil, T, Olsen, J, Orain, F, Palermo, F, Papp, G, Paradela Perez, I, Pautasso, G, Enzel, F, Petersson, P, Pinzon, J, Piovesan, P, Piron, C, Plaum, B, Ploeckl, B, Plyusnin, V, Pokol, G, Poli, E, Porte, L, Potzel, S, Prisiazhniuk, D, Puetterich, T, Ramisch, M, Rapson, C, Rasmussen, J, Raupp, G, Refy, D, Reich, M, Reimold, F, Ribeiro, T, Riedl, R, Rittich, D, Rocchi, G, Rodriguez-Ramos, M, Rohde, V, Ross, A, Rott, M, Rubel, M, Ryan, D, Ryter, F, Saarelma, S, Salewski, M, Salmi, A, Sanchis-Sanchez, L, Santos, G, Santos, J, Sauter, O, Scarabosio, A, Schall, G, Schmid, K, Schmitz, O, Schneider, P, Schneller, M, Schrittwieser, R, Schubert, M, Schwarz-Selinger, T, Schweinzer, J, Scott, B, Sehmer, T, Sertoli, M, Shabbir, A, Shalpegin, A, Shao, L, Sharapov, S, Siccinio, M, Sieglin, B, Sigalov, A, Silva, A, Silva, C, Simon, P, Simpson, J, Snicker, A, Sommariva, C, Sozzi, C, Spolaore, M, Stejner, M, Stober, J, Stobbe, F, Stroth, U, Strumberger, E, Suarez, G, Sugiyama, K, Sun, H, Suttrop, W, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Terranova, D, Tierens, W, Told, D, Tudisco, O, Trevisan, G, Treutterer, W, Trier, E, Tripsky, M, Valisa, M, Valovic, M, Vanovac, B, Varela, P, Varoutis, S, Verdoolaege, G, Vezinet, D, Vianello, N, Vicente, J, Vierle, T, Viezzer, E, von Toussaint, U, Wagner, D, Wang, N, Wang, X, Weidl, M, Weil, White, A, Willensdorfer, M, Wiringer, B, Wischmeier, M, Wolf, R, Wolfrum, E, Xiang, L, Yang, Q, Yang, Z, Yu, Q, Zagorski, R, Zammuto, I, Zarzoso, D, Zhang, W, van Zeeland, M, Zehetbauer, T, Zilker, M, Zoletnik, S, Zohm, H, Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratoire de Physique des Plasmas (LPP), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), York Plasma Institute (YPI), University of York [York, UK], EURATOM/CCFE Fusion Association, Culham Science Centre [Abingdon], Istituto di Fisica del Plasma, EURATOM-ENEA-CNR Association, Consiglio Nazionale delle Ricerche [Roma] (CNR), Leopold Franzens Universität Innsbruck - University of Innsbruck, Institute of Plasma Physics [Praha], Association EURATOM-TEKES, Helsinki University of Technology, Finland, Instituto de Plasmas e Fusão Nuclear [Lisboa] (IPFN), Institute of Atomic Physics, Université de Roumanie, FOM Institute for Atomic and Molecular Physics (AMOLF), FOM Institute DIFFER - Dutch Institute for Fundamental Energy Research, The Netherlands, Culham Centre for Fusion Energy (CCFE), University College Cork (UCC), Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), KFKI Research Institute for Particle and Nuclear Physics (KFKI-RMKI), National Technical University of Athens [Athens] (NTUA), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Department of Mechanical and Aerospace Engineering [Univ California San Diego] (MAE - UC San Diego), University of California (UC)-University of California (UC), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), General Atomics [San Diego], Ricerca Formazione Innovazione (Consorzio RFX), Warsaw University of Technology [Warsaw], Physique des interactions ioniques et moléculaires ( PIIM ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Max Planck Institute for Plasma Physics, Ecole Polytechnique Fédérale de Lausanne ( EPFL ), Laboratoire de Physique des Plasmas ( LPP ), Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Observatoire de Paris-École polytechnique ( X ) -Sorbonne Universités-PSL Research University ( PSL ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), York Plasma Institute ( YPI ), Culham Science Centre, Consiglio Nazionale delle Ricerche [Roma] ( CNR ), Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. RNM138: Física Nuclear Aplicada, IST, VTT Technical Research Centre of Finland, Max Planck Inst Astrophys, Max Planck Society, Department of Applied Physics, TEC, JET EFDA, Culham Sci Ctr, Technische Universität München, Consorzio RFX, IRFM, Assoc EURATOM FZJ, Euratom, Julich Research Center, Forschungszentrum Julich, Inst Energy & Climate Res, University of Lorraine, ENEA, Istituto Fisica del Plasma 'Piero Caldirola' (IFP-CNR), Swiss Federal Institute of Technology Lausanne, Innsbruck Medical University, Hungarian Academy of Sciences, Institute of Plasma Physics & Laser Microfusion (IFPiLM), Karlsruhe Institute of Technology, Eindhoven University of Technology, Swedish Research Council (VR), General Atomics & Affiliated Companies, University of Sevilla, University of Texas at Austin, Max Planck Comp & Data Facil, Ecole Polytechnique, Hochschule der Medien, Technical University of Denmark, Budapest University of Technology and Economics, University of California at Santa Barbara, School services, SCI, LPP-ERM/KMS EURATOM Association, Vienna University of Technology, Assoc EURATOM Hellen Republ, NCSR Demokritos, IPP, York University, CCFE Fusion Assoc, BSC, Univ Coll Cork UCC, Princeton University, Ghent University, Chinese Acad Sci, Chinese Academy of Sciences, Natl Astron Observ, Department of Radio Science and Engineering, Massachusetts Institute of Technology, Chinese Academy of Sciences, Univ Aix Marseille 1, Centre National de la Recherche Scientifique (CNRS), University of Aix-Marseille, Universite de Provence - Aix-Marseille I, UMR 6098, CNRS, Aalto-yliopisto, Aalto University, Massachusetts Institute of Technology. Plasma Science and Fusion Center, White, Anne E., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Arslanbekov, R, Atanasiu, C, Becker, G, Becker, W, Behringer, K, Bolshukhin, D, Borrass, K, Brambilla, M, Braun, F, Carlson, A, Egorov, S, Fahrbach, H, Finken, K, Foley, M, Franzen, P, Gafert, J, Fournier, K, Gantenbein, G, Gehre, O, Geier, A, Gernhardt, J, Gruber, O, Gunter, S, Hartmann, D, Heger, B, Hofmeister, F, Hohenocker, H, Horton, L, Jacchia, A, Jakobi, M, Kaufmann, M, Keller, A, Kendl, A, Kim, J, Kirov, K, Kochergov, R, Kollotzek, H, Kraus, W, Lasnier, C, Laux, M, Leonard, A, Leuterer, F, Lorenz, A, Lorenzini, R, Maggi, C, Mank, K, Martines, E, Mast, K, Meisel, D, Meo, F, Merkl, D, Muck, A, Muller, H, Munich, M, Murmann, H, Na, Y, Neuhauser, J, Nguyen, F, Nishijima, D, Nishimura, Y, Nunes, I, Peeters, A, Pereverzev, G, Pinches, S, Proschek, M, Pugno, R, Quigley, E, Roth, J, Sandmann, W, Savtchkov, A, Schade, S, Schilling, H, Schneider, W, Schramm, G, Schwarz, E, Schweizer, S, Seidel, U, Serra, F, Sesnic, S, Sihler, C, Sips, A, Speth, E, Stabler, A, Steuer, K, Streibl, B, Tabasso, A, Tanga, A, Tichmann, C, Troppmann, M, Urano, H, Vollmer, O, Wenzel, U, Wesner, F, Westerhof, E, Wursching, E, Yoon, S, Zasche, D, Zehrfeld, H, Barcelona Supercomputing Center, ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, EUROfusion MST1 Team, Adamek, J, Aho Mantila, L, Akaslompolo, S, Amdor, C, Bardin, S, Orte, L, Belonohy, E, Boom, J, Brochard, T, Bruedgam, M, Casson, F, Curran, D, da Silva, F, Eixenberger, H, Endstrasser, N, Gal, K, Munoz, M, da Graca, S, Hangan, D, Haertl, T, Hauff, T, Hoehnle, H, Ionita, C, Janzer, A, Kasparek, W, Kocan, M, Konz, C, Koslowski, R, Kubic, M, Kurki Suonio, T, Leipold, F, Lindig, S, Lisgo, S, Makkonen, T, Mehlmann, F, Menchero, L, Merz, F, Mueller, S, Mueller, H, Muenich, M, Neuwirth, D, Nold, B, Podoba, Y, Pompon, F, Polozhiy, K, Pueschel, M, Rathgeber, S, Rooij, G, Sauter, P, Sempf, M, Sommer, F, Staebler, A, Teschke, M, Tsalas, M, Van Zeeland, M, Veres, G, Viola, B, Vorpahl, C, Wachowski, M, Wauters, T, Weller, A, Wenninger, R, Wieland, B, Wuersching, E, Zhang, Y, Science and Technology of Nuclear Fusion, Max Planck IPP-EURATOM Assoziation, Universidade de Lisboa, Dutch Institute for Fundamental Energy Research, Technical University of Munich, IRFM-CEA, Forschungszentrum Jülich, Université de Lorraine, and École Polytechnique Fedérale de Lausanne

Subjects
Nuclear and High Energy Physics, Tokamak, Materials science, Energies [Àrees temàtiques de la UPC], 114 Physical sciences, 7. Clean energy, 01 natural sciences, Electron cyclotron resonance, H-MODE DISCHARGES, 010305 fluids & plasmas, law.invention, ASDEX Upgrade, overview, ASDEX Upgrade, law, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Physics::Plasma Physics, ITER, 0103 physical sciences, Fusió nuclear, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, 010306 general physics, tokamak, DEMO, tokamak physic, Fusion reactions, nuclear fusion, Divertor, Magnetic confinement fusion, [ SPI.GPROC ] Engineering Sciences [physics]/Chemical and Process Engineering, [ PHYS.PHYS.PHYS-PLASM-PH ] Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], Fusion power, Condensed Matter Physics, ___, Plasma parameter, Plasma diagnostics, Atomic physics, tokamak physics
Abstract

The ASDEX Upgrade (AUG) programme is directed towards physics input to critical elements of the ITER design and the preparation of ITER operation, as well as addressing physics issues for a future DEMO design. Since 2015, AUG is equipped with a new pair of 3-strap ICRF antennas, which were designed for a reduction of tungsten release during ICRF operation. As predicted, a factor two reduction on the ICRF-induced W plasma content could be achieved by the reduction of the sheath voltage at the antenna limiters via the compensation of the image currents of the central and side straps in the antenna frame. There are two main operational scenario lines in AUG. Experiments with low collisionality, which comprise current drive, ELM mitigation/suppression and fast ion physics, are mainly done with freshly boronized walls to reduce the tungsten influx at these high edge temperature conditions. Full ELM suppression and non-inductive operation up to a plasma current of I p = 0.8 MA could be obtained at low plasma density. Plasma exhaust is studied under conditions of high neutral divertor pressure and separatrix electron density, where a fresh boronization is not required. Substantial progress could be achieved for the understanding of the confinement degradation by strong D puffing and the improvement with nitrogen or carbon seeding. Inward/outward shifts of the electron density profile relative to the temperature profile effect the edge stability via the pressure profile changes and lead to improved/decreased pedestal performance. Seeding and D gas puffing are found to effect the core fueling via changes in a region of high density on the high field side (HFSHD). The integration of all above mentioned operational scenarios will be feasible and naturally obtained in a large device where the edge is more opaque for neutrals and higher plasma temperatures provide a lower collisionality. The combination of exhaust control with pellet fueling has been successfully demonstrated. High divertor enrichment values of nitrogen E N ⩾ 10 have been obtained during pellet injection, which is a prerequisite for the simultaneous achievement of good core plasma purity and high divertor radiation levels. Impurity accumulation observed in the all-metal AUG device caused by the strong neoclassical inward transport of tungsten in the pedestal is expected to be relieved by the higher neoclassical temperature screening in larger devices.

77. Balloon catheter for induction of labor in women with one previous cesarean and an unfavorable cervix.

Author

Huisman CMA, Ten Eikelder MLG, Mast K, Oude Rengerink K, Jozwiak M, van Dunné F, Duvekot JJ, van Eyck J, Gaugler-Senden I, de Groot CJM, Franssen MTM, van Gemund N, Langenveld J, de Leeuw JW, Oude Lohuis EJ, Oudijk MA, Papatsonis D, van Pampus M, Porath M, Rombout-de Weerd S, van Roosmalen JJ, van der Salm PCM, Scheepers HCJ, Sikkema MJ, Sporken J, Stigter RH, van Wijngaarden WJ, Woiski M, Mol BWJ, and Bloemenkamp KWM

Subjects
Adult, Cervical Ripening, Cesarean Section, Repeat, Female, Humans, Infant, Newborn, Netherlands, Pregnancy, Pregnancy Outcome, Prospective Studies, Uterine Rupture etiology, Catheterization methods, Cervix Uteri pathology, Dystocia therapy, Labor, Induced methods, Vaginal Birth after Cesarean
Abstract

Introduction: When women with a previous cesarean section and an unfavorable cervix have an indication for delivery, the choice is to induce labor or to perform a cesarean section. This study aims to assess the effectiveness and safety of a balloon catheter as a method of induction of labor in women with one previous cesarean section and an unfavorable cervix compared with an elective repeat cesarean section., Material and Methods: We performed a prospective cohort study in 51 hospitals in the Netherlands on term women with one previous cesarean section, a live singleton fetus in cephalic position, an unfavorable cervix and an indication for delivery. We recorded obstetric, maternal and neonatal characteristics. We compared the outcome of women who were induced with a balloon catheter with the outcome of women who delivered by elective repeat cesarean section. Main outcomes were maternal and neonatal morbidity. Mode of delivery was a secondary outcome for women who were induced. Adjusted odds ratios (aOR) were calculated using logistic regression, adjusted for potential confounders., Results: Analysis was performed on 993 women who were induced and 321 women who had a repeat cesarean section (August 2011 until September 2012). Among the women who were induced, 560 (56.4%) delivered vaginally and 11 (1.1%) sustained a uterine rupture. Composite adverse maternal outcome (uterine rupture, severe postpartum hemorrhage or postpartum infection) occurred in 73 (7.4%) in the balloon and 14 (4.5%) women in the repeat cesarean section group (aOR 1.58, 95% confidence interval [CI] 0.85-2.96). Composite adverse neonatal outcome (Apgar score <7 at 5 minutes or umbilical pH <7.10) occurred in 57 (5.7%) and 10 (3.2%) neonates, respectively (aOR 1.40, 95% CI 0.87-3.48). Women who were induced had a shorter postpartum admission time (2.0 vs 3.0 days (P < 0.0001))., Conclusions: In women with a previous cesarean section and a need for delivery, induction of labor with a balloon catheter does not result in a significant increase in adverse maternal and neonatal outcomes as compared with planned cesarean section., (© 2019 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).)

Published
2019
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78. First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.

Author

Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, and Holinstat M

Subjects
Animals, Dose-Response Relationship, Drug, Humans, Lipoxygenase Inhibitors administration & dosage, Lipoxygenase Inhibitors blood, Mice, Platelet Adhesiveness drug effects, Sulfonamides administration & dosage, Sulfonamides blood, Thrombin physiology, Hemostasis drug effects, Lipoxygenase Inhibitors pharmacology, Platelet Aggregation drug effects, Sulfonamides pharmacology, Thrombosis prevention & control
Abstract

Objective: Adequate platelet reactivity is required for maintaining hemostasis. However, excessive platelet reactivity can also lead to the formation of occlusive thrombi. Platelet 12(S)-lipoxygenase (12-LOX), an oxygenase highly expressed in the platelet, has been demonstrated to regulate platelet function and thrombosis ex vivo, supporting a key role for 12-LOX in the regulation of in vivo thrombosis. However, the ability to pharmacologically target 12-LOX in vivo has not been established to date. Here, we studied the effect of the first highly selective 12-LOX inhibitor, ML355, on in vivo thrombosis and hemostasis., Approach and Results: ML355 dose-dependently inhibited human platelet aggregation and 12-LOX oxylipin production, as confirmed by mass spectrometry. Interestingly, the antiplatelet effects of ML355 were reversed after exposure to high concentrations of thrombin in vitro. Ex vivo flow chamber assays confirmed that human platelet adhesion and thrombus formation at arterial shear over collagen were attenuated in whole blood treated with ML355 comparable to aspirin. Oral administration of ML355 in mice showed reasonable plasma drug levels by pharmacokinetic assessment. ML355 treatment impaired thrombus growth and vessel occlusion in FeCl 3 -induced mesenteric and laser-induced cremaster arteriole thrombosis models in mice. Importantly, hemostatic plug formation and bleeding after treatment with ML355 was minimal in mice in response to laser ablation on the saphenous vein or in a cremaster microvasculature laser-induced rupture model., Conclusions: Our data strongly support 12-LOX as a key determinant of platelet reactivity in vivo, and inhibition of platelet 12-LOX with ML355 may represent a new class of antiplatelet therapy., (© 2017 American Heart Association, Inc.)

Published
2017
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79. Improved outcomes for myeloid leukemia of Down syndrome: a report from the Children's Oncology Group AAML0431 trial.

Author

Taub JW, Berman JN, Hitzler JK, Sorrell AD, Lacayo NJ, Mast K, Head D, Raimondi S, Hirsch B, Ge Y, Gerbing RB, Wang YC, Alonzo TA, Campana D, Coustan-Smith E, Mathew P, and Gamis AS

Subjects
Antibiotics, Antineoplastic administration & dosage, Antibiotics, Antineoplastic adverse effects, Antimetabolites, Antineoplastic administration & dosage, Antimetabolites, Antineoplastic adverse effects, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Child, Preschool, Cytarabine administration & dosage, Cytarabine adverse effects, Cytogenetic Analysis, Daunorubicin administration & dosage, Daunorubicin adverse effects, Disease-Free Survival, Down Syndrome genetics, Female, Humans, Infant, Leukemia, Myeloid, Acute complications, Leukemia, Myeloid, Acute genetics, Male, Myelodysplastic Syndromes complications, Myelodysplastic Syndromes genetics, Neoplasm, Residual diagnosis, Neoplasm, Residual genetics, Treatment Outcome, Antibiotics, Antineoplastic therapeutic use, Antimetabolites, Antineoplastic therapeutic use, Cytarabine therapeutic use, Daunorubicin therapeutic use, Down Syndrome complications, Leukemia, Myeloid, Acute drug therapy, Myelodysplastic Syndromes drug therapy
Abstract

Patients with myeloid leukemia of Down syndrome (ML-DS) have favorable event-free survival (EFS), but experience significant treatment-related morbidity and mortality. ML-DS blast cells ex vivo have increased sensitivity to cytarabine (araC) and daunorubicin, suggesting that optimizing drug dosing may improve outcomes while reducing toxicity. The Children's Oncology Group (COG) AAML0431 trial consisted of 4 cycles of induction and 2 cycles of intensification therapy based on the treatment schema of the previous COG A2971 trial with several modifications. High-dose araC (HD-araC) was used in the second induction cycle instead of the intensification cycle, and 1 of 4 daunorubicin-containing induction cycles was eliminated. For 204 eligible patients, 5-year EFS was 89.9% and overall survival (OS) was 93.0%. The 5-year OS for 17 patients with refractory/relapsed leukemia was 34.3%. We determined the clinical significance of minimal residual disease (MRD) levels as measured by flow cytometry on day 28 of induction I. MRD measurements, available for 146 of the 204 patients, were highly predictive of treatment outcome; 5-year disease-free survival for MRD-negative patients (n = 125) was 92.7% vs 76.2% for MRD-positive patients (n = 21) (log-rank P = .011). Our results indicated that earlier use of HD-araC led to better EFS and OS in AAML0431 than in past COG studies. A 25% reduction in the cumulative daunorubicin dose did not impact outcome. MRD, identified as a new prognostic factor for ML-DS patients, can be used for risk stratification in future clinical trials. This trial was registered at www.clinicaltrials.gov as #NCT00369317., (© 2017 by The American Society of Hematology.)

Published
2017
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80. Women's Experiences with and Preference for Induction of Labor with Oral Misoprostol or Foley Catheter at Term.

Author

Ten Eikelder ML, van de Meent MM, Mast K, Rengerink KO, Jozwiak M, de Graaf IM, Scholtenhuis MA, Roumen FJ, Porath MM, van Loon AJ, van den Akker ES, Rijnders RJ, Feitsma AH, Adriaanse AH, Muller MA, de Leeuw JW, Visser H, Woiski MD, Weerd SR, van Unnik GA, Pernet PJ, Versendaal H, Mol BW, and Bloemenkamp KW

Subjects
Administration, Oral, Adult, Fear, Female, Humans, Internal-External Control, Labor, Induced psychology, Labor, Obstetric, Misoprostol administration & dosage, Pain etiology, Pregnancy, Random Allocation, Surveys and Questionnaires, Term Birth, Time Factors, Young Adult, Catheterization, Labor, Induced methods, Misoprostol therapeutic use, Oxytocics, Patient Preference statistics & numerical data
Abstract

Objective  We assessed experience and preferences among term women undergoing induction of labor with oral misoprostol or Foley catheter. Study Design  In 18 of the 29 participating hospitals in the PROBAAT-II trial, women were asked to complete a questionnaire within 24 hours after delivery. We adapted a validated questionnaire about expectancy and experience of labor and asked women whether they would prefer the same method again in a future pregnancy. Results  The questionnaire was completed by 502 (72%) of 695 eligible women; 273 (54%) had been randomly allocated to oral misoprostol and 229 (46%) to Foley catheter. Experience of the duration of labor, pain during labor, general satisfaction with labor, and feelings of control and fear related to their expectation were comparable between both the groups. In the oral misoprostol group, 6% of the women would prefer the other method if induction is necessary in future pregnancy, versus 12% in the Foley catheter group (risk ratio: 0.70; 95% confidence interval: 0.55-0.90; p =  0.02). Conclusion  Women's experiences of labor after induction with oral misoprostol or Foley catheter are comparable. However, women in the Foley catheter group prefer more often to choose a different method for future inductions., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)

Published
2017
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81. Induction of Labor Using a Foley Catheter or Misoprostol: A Systematic Review and Meta-analysis.

Author

Ten Eikelder ML, Mast K, van der Velden A, Bloemenkamp KW, and Mol BW

Subjects
Catheterization adverse effects, Catheterization methods, Female, Humans, Oxytocics pharmacology, Pregnancy, Pregnancy Outcome, Risk Assessment, Labor, Induced adverse effects, Labor, Induced methods, Misoprostol pharmacology
Abstract

Importance: Induction of labor is a widely used obstetric intervention, occurring in one in four pregnancies. When the cervix is unfavorable, still many different induction methods are used., Objective: We compared Foley catheter alone to different misoprostol dosages and administration routes, and the combination of Foley catheter with misoprostol., Evidence Acquisition: We reviewed the literature on the best induction method regarding their safety and effectiveness, using the outcome measures hyperstimulation, fetal distress, neonatal morbidity and mortality as well as cesarean delivery, vaginal instrumental delivery, and maternal morbidity. We searched Pubmed, Cochrane, and Web of Science from January 1, 1980 to February 12, 2016. Twenty-two randomized controlled trials (RCTs) were included, comparing Foley catheter with or without misoprostol to misoprostol alone (both vaginal and oral) for induction of labor (5,015 women)., Results: Most included studies were underpowered to detect differences in safety outcomes, as the majority are powered for time to delivery or cesarean delivery. Meta-analysis of these studies does not allow assessment of the safety profile of Foley catheter compared to misoprostol (any dose, any administration route) with sufficient power. For the safety outcomes of the total group of Foley catheter versus misoprostol (any dose, any administration route) (17 studies, 4,234 women) we found that Foley catheter results in less hyperstimulation compared to misoprostol (2% versus 4%; risk ratio [RR], 0.54; 95% confidence interval [CI], 0.37-0.79) and fewer cesarean deliveries for nonreassuring fetal heart rate, 5% vs 7%; RR, 0.72; 95% CI, 0.55-0.95; while there were no statistically significant differences in neonatal outcomes. The total number of cesarean deliveries was 26% versus 22% (RR, 1.16; 95% CI, 1.00-1.34). There were fewer vaginal instrumental deliveries with a Foley catheter compared to misoprostol (10% vs 14%; RR, 0.74; 95% CI, 0.60-0.91). Foley catheter with misoprostol compared to misoprostol alone (any dose, any administration route) (7 studies, 1,073 women) resulted in less hyperstimulation than misoprostol alone (17% vs 23%; RR, 0.71; 95% CI, 0.52-0.97). Cesarean deliveries for nonreassuring fetal heart rate were comparable (7% vs 9%; RR, 0.79; 95% CI, 0.51-1.22). Neonatal outcomes were infrequently reported. The total number of cesarean deliveries was 34% versus 34% (RR, 1.01; 95% CI, 0.86-1.19)., Conclusion: In women with an unripe cervix at term, Foley catheter seems to have a better safety profile than misoprostol (any dose, any administration route) for induction of labor. Larger studies are needed to investigate the safety profile of a Foley catheter compared to separate dosing and administration regimens of misoprostol.

Published
2016
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83. Large granules in the peripheral blood smear and bone marrow aspirate of a 3-year-old male with lymphadenopathy and fever.

Author

McCoy MH, Mast K, Relich RF, Girgis G, and Nassiri M

Subjects
Blood, Child, Preschool, Humans, Infectious Mononucleosis diagnosis, Male, Bone Marrow pathology, Fever pathology, Lymphatic Diseases pathology
Abstract

A 3-year-old male with oculocutaneous albinism presented with lymphadenopathy and fever. Serological testing revealed Epstein-Barr virus (EBV)-specific immunoglobulin M (IgM) and a diagnosis of infectious mononucleosis was made. A complete blood count and peripheral blood smear demonstrated mild anemia, thrombocytopenia, and neutropenia with leukocytes that contained large azurophilic and eosinophilic granules. Bone marrow examination demonstrated increased hemophagocytic histiocytes along with granulocytes that contained large eosinophilic granules. In addition to hemophagocytic lymphohistiocytosis, presumably due to acute EBV infection, the patient was diagnosed with Chediak-Higashi syndrome based on the pathognomonic granules within peripheral leukocytes and precursors. The differential diagnosis of a young patient with oculocutaneous albinism presenting with an acute viral infection includes a relatively narrow range of genetic syndromes based solely on the history of albinism. This case demonstrates the application of clinical laboratory data to presumptively diagnose Chediak-Higashi syndrome in the midst of a presentation of hemophagocytic lymphohistiocytosis secondary to acute EBV infection., (Copyright© by the American Society for Clinical Pathology (ASCP).)

Published
2014
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84. Ribavirin-induced externalization of phosphatidylserine in erythrocytes is predominantly caused by inhibition of aminophospholipid translocase activity.

Author

Kleinegris MC, Koek GH, Mast K, Mestrom EH, Wolfs JL, and Bevers EM

Subjects
Adenosine Triphosphate metabolism, Cells, Cultured, Erythrocytes metabolism, Hemolysis drug effects, Humans, Phospholipid Transfer Proteins metabolism, Antiviral Agents pharmacology, Erythrocytes drug effects, Ionomycin pharmacology, Phosphatidylserines metabolism, Phospholipid Transfer Proteins antagonists & inhibitors, Ribavirin pharmacology
Abstract

Ribavirin in combination with interferon-α is the standard treatment for chronic hepatitis C, but often induces severe anemia forcing discontinuation of the therapy. Whereas suppression of bone marrow by interferon may impact on the production of erythrocytes, it has been suggested that accumulation of ribavirin in erythrocytes induces alterations causing an early removal of these cells by the mononuclear phagocytic system. Externalization of phosphatidylserine, which is exclusively present in the cytoplasmic leaflet of the plasma membrane, is a recognition signal for phagocytosis in particular of apoptotic cells. Here, we demonstrate that surface exposure of phosphatidylserine upon prolonged treatment of erythrocytes with ribavirin results mainly from inactivation of the aminophospholipid translocase, an ATP-dependent lipid pump, which specifically transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane. Inactivation is due to severe ATP depletion, although competitive inhibition by ribavirin or its phosphorylated derivatives cannot be excluded. Phospholipid scramblase, responsible for collapse of lipid asymmetry, appears to be of minor importance as erythrocytes of patients with the Scott syndrome, lacking Ca(2+)-induced lipid scrambling, are equally sensitive to ribavirin treatment. Neither the antioxidant N-acetylcysteine nor the pan-caspase inhibitor Q-VD-OPH did affect ribavirin-induced phosphatidylserine exposure, suggesting that oxidative stress or apoptotic-related mechanisms are not involved in this process. In conclusion, we propose that spontaneous loss of lipid asymmetry, not corrected by aminophospholipid translocase activity, is the mechanism for ribavirin-induced phosphatidylserine exposure that may contribute to ribavirin-induced anemia., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2012
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85. Observation of continuous divertor detachment in H-mode discharges in ASDEX upgrade.

Author

Gruber O, Kallenbach A, Kaufmann M, Lackner K, Mertens V V, Neuhauser J, Ryter F, Zohm H, Bessenrodt-Weberpals M, Büchl K, Fiedler S, Field A, Fuchs C, Garcia-Rosales C, Haas G, Herrmann A, Herrmann W, Hirsch S, Köppendörfer W, Lang P, Lieder G, Mast K, Pitcher CS, Schittenhelm M, Stober J, Suttrop W, Troppmann M, Weinlich M, Albrecht M, Alexander M, Asmussen K, Ballico M, Behler K, Behringer K, Bosch HS, Brambilla M, Carlson A, Coster D, Cupido L, DeBlank HJ, De Pena Hempel S, Deschka S, Dorn C, Drube R, Dux R, Eberhagen A, Engelhardt W, Fahrbach H, Feist H, Fieg D, Fu beta mann G, Gehre O, Gernhardt J, Ignacz P, Jüttner B, Junker W, Kass T, Kiemer K, Kollotzek H, Kornherr M, Krieger K, Kurzan B, Lang R, and Laux M

Published
1995
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