51. A case of anti-GA1 antibody-positive Fisher syndrome with elevated tau protein in cerebrospinal fluid
- Author
-
Ichiro Kamioka, Noriko Ohnishi, Masao Adachi, Aika Watanabe, Hiroaki Taniguchi, Takashi Shiihara, Atsushi Nishiyama, Mitsuro Kobayashi, Yoshinobu Oyazato, and Susumu Kusunoki
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Tau protein ,tau Proteins ,Autoimmune Diseases of the Nervous System ,Cerebrospinal fluid ,Developmental Neuroscience ,Gangliosides ,Campylobacter Infections ,medicine ,Humans ,Child ,Autoantibodies ,Diplopia ,Enterocolitis ,Miller Fisher Syndrome ,biology ,Guillain-Barre syndrome ,business.industry ,External ophthalmoplegia ,Fisher Syndrome ,General Medicine ,medicine.disease ,Up-Regulation ,Pediatrics, Perinatology and Child Health ,biology.protein ,Neurology (clinical) ,medicine.symptom ,Antibody ,business - Abstract
We describe a boy with Fisher syndrome. He presented the typical symptoms of Fisher syndrome, including external ophthalmoplegia, abnormality of convergence, and areflexia, after an episode of Campylobacter enterocolitis. Atypically, however, anti-GA1 antibody was detected in his serum, though anti-GQ1b and anti-GT1a antibodies were not. In addition, the tau protein level in his cerebrospinal fluid was elevated. Generally, Fisher syndrome is a self-limiting disease and has a good prognosis. In our patient, however, mild diplopia and areflexia persisted 6 months after their onset. Here, we report on the first Fisher syndrome patient with anti-GA1 antibody in the serum and elevated tau protein in the cerebrospinal fluid.
- Published
- 2012