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442 results on '"Marzilli M."'

51. Assessment of Residual Viability by Enoximone Echocardiography in Patients with Previous Myocardial Infarction Correlation with Positron Emission Tomographic Studies and Functional Follow-Up

Author

Lu, F, Carlino, M, Lu, C, Landoni, C, Lucignani, G, Fragasso, G, Bello, V, Margonato, A, Chierchia, S, Marzilli, M, Balbarini, A, Bello, VD, Chierchia, SL, Balbarini, A., LANDONI, CLAUDIO, Lu, F, Carlino, M, Lu, C, Landoni, C, Lucignani, G, Fragasso, G, Bello, V, Margonato, A, Chierchia, S, Marzilli, M, Balbarini, A, Bello, VD, Chierchia, SL, Balbarini, A., and LANDONI, CLAUDIO

Abstract

Background: The aim of this study was to evaluate enoximone echocardiography (EE) for the identification of residual myocardial viability in postinfarction patients. Findings obtained during EE were compared with those acquired by myocardial uptake of fluorine-18 fluorodeoxyglucose ( 18F-FDG) positron emission tomography (PET) and functional follow-up results. Methods: Twenty-five patients underwent EE and PET 18F-FDG studies. An asynergic segment was considered as having contractile enhancement when the wall motion score decreased by ≥1 grade during EE and was defined as viable if 18F-FDG uptake score was ≥2 grade on PET. Results: Of 293 dysfunctional segments at baseline, 139 (47%) were viable by PET criteria; 117 (40%) had contractile enhancement induced by enoximone (P = 0.07). Agreement between EE and PET was found in 75% of involved segments (K = 0.46, P < 0.001). The majority of discrepancies (65%, P < 0.01) were mainly due to discordant segments in which PET revealed evidence of 18F-FDG uptake but EE showed no change in wall motion. In 179 revascularized segments, negative predictive value for functional recovery of both tests reached the same value (89% for both), whereas positive predictive value was 82% for EE and 68% for PET, respectively (P < 0.05). Sensitivity was 85% for EE and 88% for PET (P = ns); specificity was 87% and 70%, respectively (P < 0.01). Conclusions: EE yields a fair concordance with PET study. Compared with PET, despite a similar negative accuracy, EE shows a greater specificity for prediction of function recovery after revascularization

Published
2010

52. Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction

Author

Giannotti, G, Doerries, C, Mocharla, P S, Mueller, M F, Bahlmann, F H, Horvàth, T, Jiang, H, Sorrentino, S A, Steenken, N, Manes, C, Marzilli, M, Rudolph, K L, Lüscher, T F, Drexler, H, Landmesser, U, Giannotti, G, Doerries, C, Mocharla, P S, Mueller, M F, Bahlmann, F H, Horvàth, T, Jiang, H, Sorrentino, S A, Steenken, N, Manes, C, Marzilli, M, Rudolph, K L, Lüscher, T F, Drexler, H, and Landmesser, U

Abstract

Prehypertension is a highly frequent condition associated with an increased cardiovascular risk. Endothelial dysfunction is thought to promote the development of hypertension and vascular disease; however, underlying mechanisms remain to be further determined. The present study characterizes for the first time the in vivo endothelial repair capacity of early endothelial progenitor cells (EPCs) in patients with prehypertension/hypertension and examines its relation with endothelial function. Early EPCs were isolated from healthy subjects and newly diagnosed prehypertensive and hypertensive patients (n=52). In vivo endothelial repair capacity of EPCs was examined by transplantation into a nude mouse carotid injury model. EPC senescence was determined (RT-PCR of telomere length). NO and superoxide production of EPCs were measured using electron spin resonance spectroscopy analysis. CD34(+)/KDR(+) mononuclear cells and circulating endothelial microparticles were examined by fluorescence-activated cell sorter analysis. Endothelium-dependent and -independent vasodilations were determined by high-resolution ultrasound. In vivo endothelial repair capacity of EPCs was substantially impaired in prehypertensive/hypertensive patients as compared with healthy subjects (re-endothelialized area: 15+/-3%/13+/-2% versus 28+/-3%; P<0.05 versus healthy subjects). Senescence of EPCs in prehypertension/hypertension was substantially increased, and NO production was markedly reduced. Moreover, reduced endothelial repair capacity of early EPCs was significantly related to an accelerated senescence of early EPCs and impaired endothelial function. The present study demonstrates for the first time that in vivo endothelial repair capacity of early EPCs is reduced in patients with prehypertension and hypertension, is related to EPC senescence and impaired endothelial function, and likely represents an early event in the development of hypertension.

Published
2010

59. Valutazione quantitativa della dinamica della parete coronarica nell'uomo: Descrizione di un nuovo metodo basato sulla ricostruzione tridimensionale tempo dipendente di immagini ecografiche intravascolari

Author

Marraccini P., Salvetti O., Marzilli M., Braccini G., Levorato D., Bragagni P., and L'Abbate A.

Subjects
Vasomotion, Three-dimensional recostruction, Intravascular ultrasound, Coronary dynamics
Abstract

BACKGROUND. Intravascular ultrasound imaging provides information on vascular lumen and arterial wall structure and it has potential application in arterial wall dynamic study. The aim of this study was to develop a computer assisted system for analysing digitised cross sectional ultrasound images of coronaries to easily display and quantify coronary dynamic and its relationship with arterial wall morphology. METHODS AND RESULTS. To extract the anatomical regions of interest from the digitised sonograms, automatic image segmentation and interactive procedures for manual correction were implemented. This step included the recognition of the lumen edge and an analysis of gray level intensity of the wall. Subsequently, a virtual 3D reconstruction of lumen and vessel wall was done in a Cartesian system where the XY plane was parallel to each cross-sectional sonogram, while the Z axis corresponded to the acquisition time. The baricentre of vascular lumen was used as a reference for alignment. We obtained a cylinder-like solid representing the behaviour of the arterial cross-sectional sonogram in time, with the possibility to look either at the wall or at the lumen. In this virtual solid it was possible to measure the variation of lumen area and of 16 emidiameters; in addition, the derivatives of these values, allowing an estimate of the velocity of events, can be obtained. CONCLUSIONS. The described computerised system for the analysis of intravascular ultrasound images could become a very useful tool for 3D representation and quantitative monitoring of coronary compliance and their relationship with segmental arterial wall morphology.

Published
1996

62. Hemostatic parameters do not predict restenosis after coronary angioplasty;

Author

Uebis, R., Thompson, S.G., Marzilli, M., Bertina, R.M., Dahl, M. vom, Fechtrup, C., Casaccia, M., Pyke, S., Haverkate, F., and TNO Preventie en Gezondheid

Subjects
Health, Healthy for Life, Healthy Living
Abstract

s From the 68th Scientific Sessions, Anaheim Convention Center Anaheim, California November 13-16, 1995

Published
1995

63. Quantitative analysis of coronary dynamics by time-dependent ultrasound imaging

Author

Marraccini P., Salvetti O., Braccini G., Bragagni P., Levorato D., L'Abbate A., and Marzilli M.

Subjects
Image Processing and computer vision, Ultrasound imaging
Abstract

Intravascular ultrasound imaging is a new technique that displays information on lumen and arterial walls, and is capable of providing real-time monitoring of cross-sectional high- resolution images. This technique has potential application for studying the dynamics of the arterial wall with respect to the presence or absence of pathology and the vascular response to physiological or pharmacological stimuli. Although the extraction of information related to coronary dynamics and wall pathologies is possible by manual procedures it is very time consuming and influenced by intra- and interobserver errors. We developed an evaluation system for analyzing 3D spaces defined by digitized cross-sectional ultrasound images of coronaries quantifying the vasomotion in relation to the morphology of the arterial wall. Sequences of echographic images were obtained and recorded as ordered stacks of 2D frames on a VHS videotape. For each image, an automatic lumen edge segmentation was performed, then 3D reconstruction was obtained to evaluate time-dependent lumen and vessel wall changes. These 3D representations serve to demonstrate dynamic phenomena and to perform quantitative analyses (e.g., area/hemidiameter variations, projections, sections, 'carving,' etc.).

Published
1995

66. Coronary vasomotion evaluation by three-dimensional reconstruction of intravascular ultrasound images

Author

Salvetti O., Marraccini P., Braccini G., Bragagni P., Levorato D., L'Abbate A., and Marzilli M.

Subjects
Life and medical sciences, Utrasaund, Image
Abstract

The aim of this study was to develop a diagnostic and evaluation system for analyzing 3D spaces defined by digitized cross-sectional US images of coronaries to quantify the vasomotion in relation to the morphology of arterial wall. Sequences of echographic images were obtained to have ordered stacks of 2D frames recorded on a VHS videotape. For each image, an automatic lumen edge segmentation is performed, then 3D reconstruction is obtained to evaluate time-dependent lumen and vessel wall modifications. Directly on 3D volumes, dynamic phenomena can be evidenced and quantitative analysis can be performed (e.g., area/hemidiameter variations, projections, sections, `carving', etc.).

Published
1994

68. Moderated Posters session I: The role of echocardiography in valvular interventions * Thursday 9 December 2010, 10:00-11:00

Author

Zhao, Y., primary, Lindqvist, P., additional, Nilsson, J., additional, Holmgren, A., additional, Naslund, U., additional, Henein, M. Y., additional, Bhan, A., additional, Dworakowski, R., additional, Smith, L., additional, Brickham, B., additional, Maccarthy, P., additional, Monaghan, M. J., additional, Schattke, S., additional, Baldenhofer, G., additional, Prauka, I., additional, Laule, M., additional, Stangl, V., additional, Stangl, K., additional, Baumann, G., additional, Knebel, F., additional, Seck, C., additional, Mueller-Ehmsen, J., additional, Strauch, J., additional, Hoppe, U. C., additional, Zobel, C., additional, Di Bello, V., additional, Giannini, C., additional, Talini, E., additional, De Carlo, M., additional, Guarracino, F., additional, Delle Donne, M. G., additional, Nardi, C., additional, Dini, F. L., additional, Marzilli, M., additional, Petronio, A. S., additional, Gripari, P., additional, Tamborini, G., additional, Muratori, M., additional, Maffessanti, F., additional, Fusini, L., additional, Fusari, M., additional, Bona, V., additional, Bartorelli, A., additional, Biglioli, P., additional, Pepi, M., additional, Maier, R., additional, Stoschitzky, G., additional, Hoedl, R., additional, Watzinger, N., additional, Blazek, S., additional, Paetzold, D., additional, Pieske, B., additional, Luha, O., additional, Yong, Z. Y., additional, Boerlage - Van Dijk, K., additional, Koch, K. T., additional, Vis, M. M., additional, Bouma, B. J., additional, Henriques, J. P. S., additional, Cocchieri, R., additional, De Mol, B. A. J. M., additional, Piek, J. J., additional, Baan, J., additional, Kapetanakis, S., additional, Byrne, J., additional, Redwood, S., additional, Thomas, M. R., additional, Hancock, J., additional, Ben Zekry, S., additional, Little, S. H., additional, Mcculloch, M. L., additional, Karanbir, S., additional, Herrera, E. L., additional, Xu, J., additional, Lawrie, G. M., additional, and Zoghbi, W. A., additional

Published
2010
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69. Oral session V: New Insights on left ventricular function in aortic stenosis * Friday 10 December 2010, 08:30-10:00

Author

Calin, A., primary, Popescu, B. A., additional, Beladan, C. C., additional, Rosca, M., additional, Muraru, D., additional, Lupascu, L., additional, Calin, C., additional, Jurcut, R., additional, Sandu, C., additional, Ginghina, C., additional, O'Connor, K., additional, Romano, G., additional, Magne, J., additional, Calin, A., additional, Pierard, L., additional, Lancellotti, P., additional, Attias, D., additional, Dreyfus, J., additional, Brochet, E., additional, Berjeb, N., additional, Cueff, C., additional, Cimadevilla, C., additional, Lepage, L., additional, Iung, B., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Kempny, A., additional, Diller, G. P., additional, Orwat, S., additional, Kaleschke, G., additional, Kerckhoff, G., additional, Radke, R. M., additional, Schmidt, R., additional, Mascherbauer, J., additional, Reinecke, H., additional, Baumgartner, H., additional, Di Bello, V., additional, Giannini, C., additional, Talini, E., additional, De Carlo, M., additional, Delle Donne, M. G., additional, Guarracino, F., additional, Nardi, C., additional, Dini, F. L., additional, Marzilli, M., additional, and Petronio, A. S., additional

Published
2010
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70. Early Left Ventricular Mechanics Abnormalities in Prehypertension: A Two-Dimensional Strain Echocardiography Study

Author

Bello, V. D., primary, Talini, E., additional, Dell'Omo, G., additional, Giannini, C., additional, Delle Donne, M. G., additional, Canale, M. L., additional, Nardi, C., additional, Palagi, C., additional, Dini, F. L., additional, Penno, G., additional, Prato, S. D., additional, Marzilli, M., additional, and Pedrinelli, R., additional

Published
2010
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72. Transvenous removal of pacing and implantable cardiac defibrillating leads using single sheath mechanical dilatation and multiple venous approaches: high success rate and safety in more than 2000 leads

Author

Bongiorni, M. G., primary, Soldati, E., additional, Zucchelli, G., additional, Di Cori, A., additional, Segreti, L., additional, De Lucia, R., additional, Solarino, G., additional, Balbarini, A., additional, Marzilli, M., additional, and Mariani, M., additional

Published
2008
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86. 118. Increased pressor responsiveness to exercise and reduced exercise tolerance are associated with abnormal myocardial perfusion in patients with essential hypertension and normal coronary angiograms

Author

Palombo, Carlo, primary, Neglia, D., additional, Marabotti, Claudio, additional, Genovesi-Ebert, Alberto, additional, Marraccini, P., additional, Sambuceti, G., additional, Salvadori, P., additional, Nista, N., additional, Fusani, L., additional, Ghione, Sergio, additional, Marzilli, M., additional, Parodi, O., additional, and L??Abbate, Antonio, additional

Published
1991
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91. Possibilities, limitations, and technique for the study of regional myocardial perfusion in man by Xenon-1331.

Author

MASERI, A., L'ABBATE, A., MICHELASSI, C., PESOLA, A., PISANI, P., MARZILLI, M., DE NES, M., and MANCINI, P.

Abstract

The theoretical possibilities and the practical limitations of the Xenon-133 (133Xe) method for the study of regional myocardial perfusion in man are discussed.The techniques for data acquisition and processing developed over the past 5 years are described in detail. Illustrative examples of experimental findings are reported. The practical interpretation of the data, at the light of the influence of injection site, initial tracer distribution, constancy of counting geometry, spatial resolution, and Xenon retention in fat, is presented. [ABSTRACT FROM PUBLISHER]

Published
1977

92. Coronary effects of adenosine in conscious man.

Author

Marzilli, M., Klassen, G. A., Marraccini, P., Camici, P., Trivella, M. G., and L'Abbate, A.

Abstract

Adenosine has been reported to play an important role in several cardiac functions, including the regulation of total and regional myocardial perfusion. This hypothesis is based on extensive investigations in animal models, but very limited information is available on the cardiovascular actions of adenosine in conscious man and the effects of the intracoronary administration of adenosine are unknown.The purpose of this study was to measure total and regional coronary blood flow after bolus injections of 0·1, 0·5, 1·0, and 2·5 mg of adenosine into the left anterior descending coronary branch. A three-thermistor thermodilution catheter was advanced into the coronary sinus to measure simultaneously the great cardiac vein flow and the coronary sinus flow. Six patients with normal coronary angiograms and normal ventricular function completed the study.Intracoronary injections of adenosine were free from significant adverse effect and caused a dose-related increase of great cardiac vein flow. A linear relation was found between flow increment and the log of adenosine dose (y=18·929x + 74·84, r2 = 0·951). The highest flow, measured after the maximal dose, was almost three times greater than control flow (155±2 vs 58±3 ml min−1, P< 0·001).We also observed a flow response in the territory not directly exposed to adenosine, as indicated by a marked increase of coronary sinus blood flow that was linearly related to the adenosine dose (y=29·113x=112·635, r2=0·98).These preliminary observations suggest: (1) Intracoronary injections of adenosine in conscious man can be performed without significant adverse effects. (2) Intracoronary injections of adenosine result in a dose-related increment of coronary blood flow; maximal flow was obtained after 2·5mg and was almost three times greater than control flow. (3) The response to adenosine was extended to a larger territory than expected. [ABSTRACT FROM PUBLISHER]

Published
1989
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93. Platelet activation in angina at rest. Evidence by paired measurement of plasma beta-thromboglobulin and platelet factor 4*.

Author

DE CATERINA, R., GAZZETTI, P., MAZZONE, A., MARZILLI, M., and L'ABBATE, A.

Abstract

Indexes of in vivo platelet activation, beta-thromboglobulin and platelet factor 4 were measured in triplicate in plasma from venous blood of 69 patients with proven ischaemic heart disease (IHD), discarding samples with a ratio of the plasma concentrations of the two proteins <2.6, in order to rule out sampling artifacts. Compared with 60 control volunteers, differences were not significant [for beta-thromboglobulin controls (ng ml, mean±SD) 27.8–8.6, ischaemic patients 32.3±17.1; for platelet factor 4 controls 4.3±1.4, ischaemic patients 5.9±5.7]. However, when patients were stratified according to disease activity (Group I—;patients without spontaneous ischaemic episodes at rest during 4 days of continuous electrocardiographic monitoring; Group II—patients with l episode/day), these indexes were increased in ‘active’ patients (for beta-thromboglobulin, in Group II—32.4±10.5 ng ml, P<0.05 vs. Group I; in Group III—42.6±14.6 ng ml, P<0.01 vs. Group I, P<0.05 vs. control. Platelet factor 4 was increased only in Group III—8.9±7.2ng ml, P<0.05 vs. control). Beta-thromboglobulin and platelet factor 4 were 25.0±6.7 ng ml and 4.9±4.8 ng ml, respectively, in Group I (P=NS vs. control). A relationship with the number of spontaenous ischaemic episodes at rest was confirmed by linear regression analysis (in Group III patients for beta-thromboglobulin: r=0.76, P<0.01, and for platelet factor 4 r=0.62, P<0.01). Levles were not elevated in patients with pervious myocardial infarction without ischaemia at rest and/or patients with stable angina, and were not influenced by the occurrence of a positive exercise stress test. Coronary angiograms of ischaemic patients were analyzed to assess the extent and severity of atherosclerotic involvement; for both extent and severity, involvement was similar in the three groups. These data support the hypothesis of the occurrence of platelet activation in patients with spontaneous angina at rest, but not in other subsets of IHD patients, and establish the possibility of detecting in vivo platelet activation in IHD by means of such circulating markers. [ABSTRACT FROM PUBLISHER]

Published
1988
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94. Systolic and diastolic alterations of left ventricular function: Prevalence in ischaemic heart disease and importance in the management of individual patients.

Author

Marzilli, M.

Abstract

Myocardial perfusion and contractile performance are strictly interrelated. Conclusive experimental data show that changes in perfusion cause immediate changes in function, and conversely, that changes in contraction affect both total and regional myocardial blood flow.In ischaemic heart disease, both transient and permanent changes in global and/or regional left ventricular (LV) function have been described.In myocardial ischaemia, an impairment of LV relaxation, as indicated by a reduction of negative dP/dt, is the first appreciable haemodynamic event. When ischaemia is sustained, impairment of LV contraction follows, as indicated by a drop of positive dP/dt, reduction of systolic LV pressure, rise of end-diastolic LV pressure.Unrestricted reperfusion, as in experimental coronary occlusion and in Prinz-Metal angina, is associated with a transient rebound in regional systolic function.Spontaneous and/or induced changes of regional ventricular function provide relevant information for the management of the individual patient. In PTCA candidates monitoring regional contractile performance by mono and two-dimensional echocardiography during dypiridamole infusion has proven to be a sensitive and specific test for (1) assessing the haemodynamic significance of a coronary stenosis in patients with single-vessel disease, (2) identifying the ‘culprit’ lesion in patients with multiple-vessel disease.During PTCA, right and left ventricular function assessed by radionuclide angiography both at rest and during atrial pacing appears to be a sensitive method for the immediate evaluation of the efficacy of the procedure. [ABSTRACT FROM PUBLISHER]

Published
1988
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96. Is alanine release an early marker of acute myocardial infarction?

Author

CAMICI , PAOLO, Marraccini P, Buzzigoli G, Boni C, Ciociaro D, Maltinti G, Marzilli M., Camici, Paolo, Marraccini, P, Buzzigoli, G, Boni, C, Ciociaro, D, Maltinti, G, and Marzilli, M.

Subjects
Necrosis, Alanine, Myocardium, Myocardial Infarction, Humans, Female, Middle Aged
Published
1987

98. [Progressive increase of the coronary flow above peak reactive hyperemia during prolonged intracoronary infusion of adenosine (author's transl)]. FT Aumento progressivo del flusso coronarico oltre i valori dell'iperemia reattiva durante infusione intracoronarica prolungata di adenosina

Author

L'Abbate A, Trivella M. G, Pelosi G, Marzilli M, Ballestra A. M, Levantesi D, Taddei L., CAMICI , PAOLO, L'Abbate, A, Trivella M., G, Camici, Paolo, Pelosi, G, Marzilli, M, Ballestra A., M, Levantesi, D, and Taddei, L.

Published
1981

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