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465 results on '"Martin-Eauclaire, Marie-France"'

51. Structural basis of α-scorpion toxin action on Nav channels

Author

Clairfeuille, Thomas, Cloake, Alexander, Infield, Daniel, Llongueras, José, Arthur, Christopher, Li, Zhong Rong, Jian, Yuwen, Martin-Eauclaire, Marie-France, Bougis, Pierre, Ciferri, Claudio, Ahern, Christopher, Bosmans, Frank, Hackos, David, Rohou, Alexis, Jian, Jian, Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and BOUGIS, Pierre

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

55. Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels

Author

Romi-Lebrun, Regine, Lebrun, Bruno, Martin-Eauclaire, Marie-France, Ishiguro, Masaji, Escoubas, Pierre, Wu, Fang Qi, Hisada, Miki, Pongs, Olaf, and Nakajima, Terumi

Subjects
Scorpions -- Venom, Venom -- Research, Potassium channels -- Research, Ion channels -- Research, Neurotoxic agents -- Research, Biological sciences, Chemistry
Abstract

The venom of the Chinese scorpion Buthus martensi was purified and characterized for its content in toxins active on potassium ion channels. The physicochemical characterization of three toxins from Buthus martensi as well as their pharmacological properties toward the potassium ion channels were described. Results showed that the toxins are lethal neurotoxic agents in mice and potent inhibitors of the voltage-gated potassium ion channels.

Published
1997

68. Structural basis of α-scorpion toxin action on Na v channels

Author

Clairfeuille, Thomas, primary, Cloake, Alexander, additional, Infield, Daniel T., additional, Llongueras, José P., additional, Arthur, Christopher P., additional, Li, Zhong Rong, additional, Jian, Yuwen, additional, Martin-Eauclaire, Marie-France, additional, Bougis, Pierre E., additional, Ciferri, Claudio, additional, Ahern, Christopher A., additional, Bosmans, Frank, additional, Hackos, David H., additional, Rohou, Alexis, additional, and Payandeh, Jian, additional

Published
2019
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78. Neuro-Modulation of Immuno-Endocrine Response Induced by Kaliotoxin of Androctonus Scorpion Venom

Author

Ladjel-Mendil, Amina, Martin-Eauclaire, Marie-France, Laraba-Djebari, Fatima, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Calcitonin, Neutrophils, Intraventricular, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Hormone Release, Hypothalamus, Thyroid Gland, Scorpion Venoms, Thyrotropin, Injections, Scorpions, Mice, Malondialdehyde, Nitriles, Animals, Injections, Intraventricular, Catalase, Glutathione, Eosinophils, Oxidative Stress, Thyroxine, Neutrophil Infiltration, inflammation, Kaliotoxin, Triiodothyronine, Oxidation-Reduction
Abstract

International audience; Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system. Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro-immuno-endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural-functional alterations of both hypothalamus and thyroid. These alterations were characterized by a massive release of hormones' markers of thyroid function associated with damaged tissue which was infiltrated by inflammatory cell and an imbalanced redox status. Taken together, these data highlight that KTX is able to modulate the neuro-endocrine response after binding to its targets leading to the hypothalamus and the thyroid stimulation, probably by inflammatory response activation and the installation of oxidative stress in these organs.

Published
2016
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79. Solution structure of discrepin, a new K(super +)-channel blocking peptide from the alpha-KT x 15 subfamily

Author

Prochnicka-Chaufour, Ada, Prestipino, Gianfranco, Corzo, Gerardo, D'Suze, Gina, Satake, Honoo, Possani, Lourival D., Martin-Eauclaire, Marie-France, Delepierre, Muriel, and Murgia, Anna Rosa

Subjects
Molecular structure -- Research, Nuclear magnetic resonance spectroscopy -- Usage, Peptides -- Research, Biological sciences, Chemistry
Abstract

Natural discrepin (n-discrepin) was prepared from scorpion venom, and its synthetic analogue (s-discrepin) was obtained in solid-phase synthesis. The analysis of two-dimensional (super 1)H NMR spectra of the n-discrepin and s-discrepin indicated that both the peptides had the same structures.

Published
2006

80. Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms

Author

Bougis, Pierre Edouard, Martin-Eauclaire, Marie-France, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and BOUGIS, Pierre

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Scorpion Venoms, MESH: Scorpions, Scorpions, Shal Potassium Channels, MESH: Scorpion Venoms, MESH: Potassium Channel Blockers, MESH: Shal Potassium Channels, Potassium Channel Blockers, cardiovascular system, Animals, MESH: Animals, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
Abstract

International audience; Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to the α-KTx15 subfamily and which act as pore blockers, a different mode of action by comparison to spider toxins known as gating modifiers. This review summarizes our present chemical and pharmacological knowledge on the α-KTx15 toxins.

Published
2015

83. Editorial : Special issue on 'toxins: from threats to benefits'

Author

Martin-Eauclaire, Marie-France, Benoit, Evelyne, Marchot, P., Barbier, Julien, Molgó, Jordi, Servent, Denis, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Centre National de la Recherche Scientifique (CNRS), Neurobiologie et Développement (N&eD), Institut de Biologie et de Technologies de Saclay (IBITECS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013
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84. Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels

Author

Maffie, Jon K, Dvoretskova, Elena, Bougis, Pierre Edouard, Martin-Eauclaire, Marie-France, and Rudy, Bernardo

Subjects
Mice, Knockout, Neurons, Scorpion Venoms, CHO Cells, Neuroscience: Cellular/Molecular, Recombinant Proteins, Mice, Cricetulus, Shal Potassium Channels, Cerebellum, Cricetinae, cardiovascular system, Animals, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Cells, Cultured
Abstract

K+ channels containing Kv4.2 and Kv4.3 pore-forming subunits mediate most of the subthreshold-operating somatodendritic A-type K+ current in CNS neurons. These channels are believed to be important in regulating the frequency of repetitive firing, the backpropagation of action potential into dendrites, and dendritic integration and plasticity. Moreover, they have been implicated in several diseases from pain to epilepsy and autism spectrum disorders. The lack of toxins that specifically and efficiently block these channels has hampered studies aimed at confirming their functional role and their involvement in disease. AmmTX3 and other related members of the α-KTX15 family of scorpion toxins have been shown to block the A-type K+ current in cultured neurons, but their specificity has been questioned because the toxins do not efficiently block the currents mediated by Kv4.2 or Kv4.3 subunits expressed in heterologous cells. Here we show that the high-affinity blockade of Kv4.2 and Kv4.3 channels by AmmTX3 depends on the presence of the auxiliary subunits DPP6 and DPP10. These proteins are thought to be components of the Kv4 channel complex in neurons and to be important for channel expression in dendrites. These studies validate the use of AmmTX3 as a blocker of the Kv4-mediated A-type K+ current in neurons.

Published
2013

85. Ca²⁺/cAMP-sensitive covariation of I(A) and I(H) voltage dependences tunes rebound firing in dopaminergic neurons

Author

Amendola, Julien, Woodhouse, Adele, Martin-Eauclaire, Marie-France, Goaillard, Jean-Marc, Plasticité et physio-pathologie de la motricité (P3M) (PPPMP), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS)

Subjects
MESH: Rats, MESH: Potassium Channels, MESH: Rats, Wistar, MESH: Animals, Newborn, MESH: Male, MESH: Cyclic Nucleotide-Gated Cation Channels, nervous system, MESH: Calcium, MESH: Dopaminergic Neurons, MESH: Calcium Channels, MESH: Animals, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Female, MESH: Action Potentials, MESH: Cyclic AMP
Abstract

International audience; The level of expression of ion channels has been demonstrated to vary over a threefold to fourfold range from neuron to neuron, although the expression of distinct channels may be strongly correlated in the same neurons. We demonstrate that variability and covariation also apply to the biophysical properties of ion channels. We show that, in rat substantia nigra pars compacta dopaminergic neurons, the voltage dependences of the A-type (I(A)) and H-type (I(H)) currents exhibit a high degree of cell-to-cell variability, although they are strongly correlated in these cells. Our data also demonstrate that this cell-to-cell covariability of voltage dependences is sensitive to cytosolic cAMP and calcium levels. Finally, using dynamic clamp, we demonstrate that covarying I(A) and I(H) voltage dependences increases the dynamic range of rebound firing while covarying their amplitudes has a homeostatic effect on rebound firing. We propose that the covariation of voltage dependences of ion channels represents a flexible and energy-efficient way of tuning firing in neurons.

Published
2012
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86. Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus

Author

Martin-Eauclaire, Marie-France, Bougis, Pierre E, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Dumonceaud, Corinne

Subjects
Article Subject, lcsh:RA1190-1270, Review Article, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], complex mixtures, lcsh:Toxicology. Poisons
Abstract

International audience; K(+) channels selectively transport K(+) ions across cell membranes and play a key role in regulating the physiology of excitable and nonexcitable cells. Their activation allows the cell to repolarize after action potential firing and reduces excitability, whereas channel inhibition increases excitability. In eukaryotes, the pharmacology and pore topology of several structural classes of K(+) channels have been well characterized in the past two decades. This information has come about through the extensive use of scorpion toxins. We have participated in the isolation and in the characterization of several structurally distinct families of scorpion toxin peptides exhibiting different K(+) channel blocking functions. In particular, the venom from the Moroccan scorpion Androctonus mauretanicus mauretanicus provided several high-affinity blockers selective for diverse K(+) channels (SK(Ca), K(v)4.x, and K(v)1.x K(+) channel families). In this paper, we summarize our work on these toxin/channel interactions.

Published
2012
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87. Toxins and Ion transfers

Author

Barbier, Julien, Benoit, Evelyne, Gilles, Nicolas, Ladant, Daniel, Martin-Eauclaire, Marie-France, Mattei, César, Molgó, Jordi, Popoff, Michel R., Servent, Denis, Laboratoire de neurobiologie cellulaire et moléculaire (NBCM), Centre National de la Recherche Scientifique (CNRS), Neurobiologie et Développement (N&eD), Institut de Neurobiologie Alfred Fessard (INAF), Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biochimie des Interactions Macromoléculaires, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bactéries anaérobies et Toxines, Institut Pasteur [Paris] (IP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), and Institut Pasteur [Paris]

Subjects
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Abstract

Collection Rencontres en Toxinologie, ISSN 1760-6004 ; http://sfet.asso.fr/international/images/stories/SFET/pdf/Ebook-RT19-2011-signets.pdf; International audience

Published
2011

94. Scorpion α-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects

Author

Cestèle, Sandrine, Stankiewicz, Maria, Mansuelle, Pascal, De Waard, Michel, Dargent, Bénédicte, Gilles, Nicolas, Pelhate, Marcel, Rochat, Hervé, Martin-Eauclaire, Marie-France, Gordon, Dalia, Université Côte d'Azur, CNRS, UMR 7275, Institut de Pharmacologie Moléculaire et Cellulaire, Sophia Antipolis, Institute of General and Molecular Biology [Torun], Nicolaus Copernicus University [Toruń], CNRS FRE2738 (FRE2738), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre National de la Recherche Scientifique (CNRS), Département d'Ingénierie et d'Etudes des Protéines, CEN/Saclay, Laboratoire de Neurophysiologie, UFR Sciences-Centre National de la Recherche Scientifique (CNRS), Biochimie - Ingénierie des protéines, Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Plant Sciences, Tel Aviv University (TAU), Centre National de la Recherche Scientifique (CNRS)-Université de la Méditerranée - Aix-Marseille 2, and Tel Aviv University [Tel Aviv]

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1999
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96. Neuro-Modulation of Immuno-Endocrine Response Induced by Kaliotoxin of Androctonus Scorpion Venom.

Author

Ladjel‐Mendil, Amina, Martin‐Eauclaire, Marie‐France, and Laraba‐Djebari, Fatima

Abstract

ABSTRACT Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system. Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro-immuno-endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural-functional alterations of both hypothalamus and thyroid. These alterations were characterized by a massive release of hormones' markers of thyroid function associated with damaged tissue which was infiltrated by inflammatory cell and an imbalanced redox status. Taken together, these data highlight that KTX is able to modulate the neuro-endocrine response after binding to its targets leading to the hypothalamus and the thyroid stimulation, probably by inflammatory response activation and the installation of oxidative stress in these organs. [ABSTRACT FROM AUTHOR]

Published
2016
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