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53. Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Psychological Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Author

Xu, Xiaomin, Xu, Mei, Su, Yon, Cao, Thanh Vinh, Nikolin, Stevan, Moffa, Adriano, Loo, Colleen, and Martin, Donel

Subjects
PSYCHOTHERAPY, TRANSCRANIAL magnetic stimulation, RANDOMIZED controlled trials, BEHAVIOR therapy, TRANSCRANIAL direct current stimulation, COGNITIVE therapy
Abstract

(1) Background: Psychological interventions are effective in alleviating neuropsychiatric symptoms, though results can vary between patients. Repetitive transcranial magnetic stimulation (rTMS) has been proven to improve clinical symptoms and cognition. It remains unclear whether rTMS can augment the efficacy of psychological interventions. (2) Methods: We examined the effects of rTMS combined with psychological interventions on clinical, functional, and cognitive outcomes from randomized controlled trials conducted in healthy and clinical populations. We searched PubMed, EMBASE, Cochrane Library, and PsycINFO databases up to April 2023. (3) Results: Twenty-seven studies were ultimately included. Compared to sham rTMS combined with psychological interventions, active rTMS combined with psychological interventions significantly improved overall clinical symptoms (k = 16, SMD  =  0.31, CIs 0.08 to 0.54, p  <  0.01). We found that 10 or more sessions of rTMS combined with cognitive behavioural therapy significantly improved clinical outcomes overall (k = 3, SMD  =  0.21, CIs  0.05 to 0.36, Z = 2.49, p  <  0.01). RTMS combined with cognitive training (CT) significantly improved cognition overall compared to sham rTMS combined with CT (k = 13, SMD  =  0.28, CIs 0.15 to 0.42, p  <  0.01), with a significant effect on global cognition (k = 11, SMD  =  0.45, CIs 0.21 to 0.68, p  < 0.01), but not on the other cognitive domains. (4) Conclusion: The current results provide preliminary support for the augmentation effects of active rTMS on clinical and cognitive outcomes across diverse populations. Future clinical trials are required to confirm these augmentation effects for specific psychological interventions in specific clinical populations. [ABSTRACT FROM AUTHOR]

Published
2023
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54. Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial.

Author

Loo, Colleen, Glozier, Nick, Barton, David, Baune, Bernhard T., Mills, Natalie T., Fitzgerald, Paul, Glue, Paul, Sarma, Shanthi, Galvez-Ortiz, Veronica, Hadzi-Pavlovic, Dusan, Alonzo, Angelo, Dong, Vanessa, Martin, Donel, Nikolin, Stevan, Mitchell, Philip B., Berk, Michael, Carter, Gregory, Hackett, Maree, Leyden, John, and Hood, Sean

Subjects
SUBCUTANEOUS injections, CLINICAL trials, KETAMINE, BLOOD pressure, AFFECTIVE disorders
Abstract

Background: Prior trials suggest that intravenous racemic ketamine is a highly effective for treatment-resistant depression (TRD), but phase 3 trials of racemic ketamine are needed. Aims: To assess the acute efficacy and safety of a 4-week course of subcutaneous racemic ketamine in participants with TRD. Trial registration: ACTRN12616001096448 at www.anzctr.org.au. Method: This phase 3, double-blind, randomised, active-controlled multicentre trial was conducted at seven mood disorders centres in Australia and New Zealand. Participants received twice-weekly subcutaneous racemic ketamine or midazolam for 4 weeks. Initially, the trial tested fixed-dose ketamine 0.5 mg/kg versus midazolam 0.025 mg/kg (cohort 1). Dosing was revised, after a Data Safety Monitoring Board recommendation, to flexible-dose ketamine 0.5–0.9 mg/kg or midazolam 0.025–0.045 mg/kg, with response-guided dosing increments (cohort 2). The primary outcome was remission (Montgomery-Åsberg Rating Scale for Depression score ≤10) at the end of week 4. Results: The final analysis (those who received at least one treatment) comprised 68 in cohort 1 (fixed-dose), 106 in cohort 2 (flexible-dose). Ketamine was more efficacious than midazolam in cohort 2 (remission rate 19.6% v. 2.0%; OR = 12.1, 95% CI 2.1–69.2, P = 0.005), but not different in cohort 1 (remission rate 6.3% v. 8.8%; OR = 1.3, 95% CI 0.2–8.2, P = 0.76). Ketamine was well tolerated. Acute adverse effects (psychotomimetic, blood pressure increases) resolved within 2 h. Conclusions: Adequately dosed subcutaneous racemic ketamine was efficacious and safe in treating TRD over a 4-week treatment period. The subcutaneous route is practical and feasible. [ABSTRACT FROM AUTHOR]

Published
2023
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58. Transcranial Direct Current Stimulation Modulates Working Memory Maintenance Processes in Healthy Individuals

Author

Nikolin, Stevan, Martin, Donel, Loo, Colleen K, Boonstra, Tjeerd W., Nikolin, Stevan, Martin, Donel, Loo, Colleen K, and Boonstra, Tjeerd W.

Abstract

BACKGROUND: The effects of transcranial direct current stimulation (tDCS) at the pFC are often investigated using cognitive paradigms, particularly working memory tasks. However, the neural basis for the neuromodulatory cognitive effects of tDCS, including which subprocesses are affected by stimulation, is not completely understood.AIMS: We investigated the effects of tDCS on working memory task-related spectral activity during and after tDCS to gain better insights into the neurophysiological changes associated with stimulation.METHODS: We reanalyzed data from 100 healthy participants grouped by allocation to receive either sham (0 mA, 0.016 mA, and 0.034 mA) or active (1 mA or 2 mA) stimulation during a 3-back task. EEG data were used to analyze event-related spectral power in frequency bands associated with working memory performance.RESULTS: Frontal theta event-related synchronization (ERS) was significantly reduced post-tDCS in the active group. Participants receiving active tDCS had slower RTs following tDCS compared with sham, suggesting interference with practice effects associated with task repetition. Theta ERS was not significantly correlated with RTs or accuracy.CONCLUSIONS: tDCS reduced frontal theta ERS poststimulation, suggesting a selective disruption to working memory cognitive control and maintenance processes. These findings suggest that tDCS selectively affects specific subprocesses during working memory, which may explain heterogenous behavioral effects.

Published
2023

67. Comparative efficacy, cognitive effects and acceptability of electroconvulsive therapies for the treatment of depression: protocol for a systematic review and network meta-analysis

Author

Nikolin, Stevan, primary, Owens, Kieran, additional, Francis-Taylor, Rohan, additional, Chaimani, Anna, additional, Martin, Donel M, additional, Bull, Michael, additional, Sackeim, Harold A, additional, McLoughlin, Declan M, additional, Sienaert, Pascal, additional, Kellner, Charles H, additional, and Loo, Colleen, additional

Published
2022
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68. "Closing the Loop" With Transcranial Electrical Stimulation for Depression.

Author

Martin, Donel M. and Nikolin, Stevan

Subjects
*TRANSCRANIAL alternating current stimulation, *TRANSCRANIAL direct current stimulation, *DEEP brain stimulation, *TRANSCRANIAL magnetic stimulation, *TREATMENT effectiveness
Abstract

The article discusses a pilot study on the use of individualized closed loop transcranial alternating current stimulation (tACS) for the treatment of depression. Transcranial electrical stimulation (tES) has been used for depression since the 1960s and has advantages over transcranial magnetic stimulation (TMS) in terms of safety and cost. The study focused on administering tACS at an individualized frequency matched to the participant's resting state alpha frequency, with the aim of reducing neural oscillatory activity and improving mood. While the findings are promising, further research is needed to optimize parameters, assess safety, and compare the efficacy of tACS to other stimulation modalities. [Extracted from the article]

Published
2024
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77. The Clinical Alliance and Research in Electroconvulsive Therapy Network: An Australian Initiative for Improving Service Delivery of Electroconvulsive Therapy

Author

Martin, Donel M., Gálvez, Verònica, Lauf, Shani, Dong, Vanessa, Baily, Stephen A., Cardoner, Narcís, Chan, Herng N., Davidson, Don, Fam, Johnson, De Felice, Nick, Martinez-Amoros, Erika, Mohan, Titus, Ramalingam, Jothi, Sarma, Shanthi I., Tor, Phern C., Waite, Susan, and Loo, Colleen K.

Published
2018
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84. The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry

Author

Bayes, Adam, primary, Short, Brooke, additional, Zarate, Carlos A., additional, Park, Lawrence, additional, Murrough, James W., additional, McLoughlin, Declan M., additional, Riva-Posse, Patricio, additional, Schoevers, Robert, additional, Veraart, Jolien, additional, Parikh, Sagar, additional, Glue, Paul, additional, Fam, Johnson, additional, McShane, Rupert, additional, Galvez, Veronica, additional, Martin, Donel, additional, Tor, Phern-Chern, additional, Brunoni, Andre R., additional, and Loo, Colleen K., additional

Published
2022
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91. Digitizing Non-Invasive Neuromodulation Trials: Scoping Review, Process Mapping, and Recommendations from a Delphi Panel

Author

Brunoni, Andre R, primary, Ekhtiari, Hamed, additional, Antal, Andrea, additional, Auvichayapat, Paradee, additional, Baeken, Chris, additional, Benseñor, Isabela M., additional, Bikson, Marom, additional, Boggio, Paulo, additional, Borroni, Barbara, additional, Brighina, Filippo, additional, Brunelin, Jerome, additional, Carvalho, Sandra, additional, Caumo, Wolnei, additional, Ciechanski, Patrick, additional, Charvet, Leigh, additional, Clark, Vincent P., additional, Kadosh, Roi Cohen, additional, Cotelli, Maria, additional, Datta, Abhishek, additional, Deng, Zhi-De, additional, De Raedt, Rudi, additional, De Ridder, Dirk, additional, Fitzgerald, Paul B., additional, Floel, Agnes, additional, Frohlich, Flavio, additional, George, Mark S., additional, Ghobadi-Azbari, Peyman, additional, Goerigk, Stephan, additional, Hamilton, Roy H., additional, Jaberzadeh, Shapour J., additional, Hoy, Kate, additional, Kidgell, Dawson J., additional, Zonoozi, Arash Khojasteh, additional, Kirton, Adam, additional, Laureys, Steven, additional, Lavidor, Michal, additional, Lee, Kiwon, additional, Leite, Jorge, additional, Lisanby, Sarah H., additional, Loo, Colleen, additional, Martin, Donel M., additional, Miniussi, Carlo, additional, Mondino, Marine, additional, Monte-Silva, Katia, additional, Morales-Quezada, Leon, additional, Nitsche, Michael A., additional, Okano, Alexandre H., additional, Oliveira, Claudia S., additional, Onarheim, Balder, additional, Pacheco-Barrios, Kevin, additional, Padberg, Frank, additional, Nakamura-Palacios, Ester M, additional, Palm, Ulrich, additional, Paulus, Walter, additional, Plewnia, Christian, additional, Priori, Alberto, additional, Rajji, Tarek K., additional, Razza, Lais B., additional, Rehn, Erik M., additional, Ruffini, Giulio, additional, Schellhorn, Klaus, additional, Zare-Bidoky, Mehran, additional, Simis, Marcel, additional, Skorupinski, Pawel, additional, Suen, Paulo, additional, Thibaut, Aurore, additional, Valiengo, Leandro C. L., additional, Vanderhasselt, Marie-Anne, additional, Vanneste, Sven, additional, Venkatasubramanian, Ganesan, additional, Violante, Ines R., additional, Wexler, Anna, additional, Woods, Adam J., additional, and Fregni, Felipe, additional

Published
2022
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95. Digitizing Non-Invasive Neuromodulation Trials: Scoping Review, Process Mapping, and Recommendations from a Delphi Panel

Author

Brunoni, André Russowsky, primary, Ekhtiari, Hamed, additional, Antal, Andrea, additional, Auvichayapat, Paradee, additional, Baeken, Chris, additional, Benseñor, Isabela M., additional, Bikson, Marom, additional, Boggio, Paulo, additional, Borroni, Barbara, additional, Brighina, Filippo, additional, Brunelin, Jerome, additional, Carvalho, Sandra, additional, Caumo, Wolnei, additional, Ciechanski, Patrick, additional, Charvet, Leigh, additional, Clark, Vincent P., additional, Cohen Kadosh, Roi, additional, Cotelli, Maria, additional, Datta, Abhishek, additional, Deng, Zhi-De, additional, De Raedt, Rudi, additional, De Ridder, Dirk, additional, Fitzgerald, Paul B., additional, Floel, Agnes, additional, Frohlich, Flavio, additional, George, Mark S., additional, Ghobadi-Azbari, Peyman, additional, Goerigk, Stephan, additional, Hamilton, Roy H., additional, Jaberzadeh, Shapour, additional, Hoy, Kate, additional, Kidgell, Dawson, additional, Khojasteh Zonoozi, Arash, additional, Kirton, Adam, additional, Laureys, Steven, additional, Lavidor, Michal, additional, Lee, Kiwon, additional, Leite, Jorge, additional, Lisanby, Sarah H., additional, Loo, Colleen, additional, Martin, Donel M., additional, Miniussi, Carlo, additional, Mondino, Marine, additional, Monte-Silva, Kátia, additional, Morales-Quezada, Leon, additional, Nitsche, Michael, additional, Hideki Okano, Alexandre, additional, S. Oliveira, Claudia, additional, Onarheim, Balder, additional, Pacheco-Barrios, Kevin, additional, Padberg, Frank, additional, Nakamura-Palacios, Ester M., additional, Palm, Ulrich, additional, Paulus, Walter, additional, Plewnia, Christian, additional, Priori, Alberto, additional, Rajji, Tarek K., additional, Razza, Lais B., additional, Rehn, Erik M., additional, Ruffini, Giulio, additional, Schellhorn, Klaus, additional, Zare-Bidoky, Mehran, additional, Simis, Marcel, additional, Skorupinski, Pawel, additional, Suen, Paulo, additional, Thibaut, Aurore, additional, Valiengo, Leandro C. L., additional, Vanderhasselt, Marie-Anne, additional, Vanneste, Sven, additional, Venkatasubramanian, Ganesan, additional, Violante, Ines R., additional, Wexler, Anna, additional, Woods, Adam J., additional, and Fregni, Felipe, additional

Published
2022
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96. Efficacy and Safety of Repeated Subcutaneous Ketamine Injections for Treatment Resistant Depression - The KADS Study: A Randomised, Double-Blind, Comparator-Controlled Trial

Author

Loo, Colleen, primary, Glozier, Nicholas, additional, Barton, David, additional, Baune, Bernhard, additional, Mills, Natalie, additional, Fitzgerald, Paul B., additional, Glue, Paul, additional, Sarma, Shanthi, additional, Galvez-Ortiz, Veronica, additional, Hadzi-Pavlovic, Dusan, additional, Alonzo, Angelo, additional, Dong, Vanessa, additional, Martin, Donel M., additional, Nikolin, Stevan, additional, Mitchell, Philip, additional, Berk, Michael, additional, Carter, Gregory, additional, Hackett, Maree, additional, Leyden, John, additional, Hood, Sean, additional, Somogyi, Andrew, additional, Lapidus, Kyle, additional, stratton, elizabeth, additional, Lyrtzis, Ellen, additional, Gainsford, Kirsten, additional, Neehoff, Shona, additional, Garg, Deepak, additional, Thornton, Nicollette, additional, Fourrier, Célia, additional, Richardson, Karyn, additional, Rozakis, Demi, additional, Scaria, Anish, additional, Mihalopoulos, Cathrine, additional, Chatterton, Mary Lou, additional, McDonald, William, additional, Boyce, Philip, additional, Holtzheimer, Paul, additional, Kozel, Frank Andrew, additional, Riva-Posse, Patricio, additional, and Rodgers, Anthony, additional

Published
2022
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