Search

Your search keyword '"Marquez, Victor E."' showing total 1,219 results
Start Over Author "Marquez, Victor E."
1,219 results on '"Marquez, Victor E."'

51. Supplementary Table 5 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
Full Text
View/download PDF

52. Supplementary Figure 1 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
Full Text
View/download PDF

55. Supplementary Table 2 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
Full Text
View/download PDF

56. Supplementary Table 3 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
Full Text
View/download PDF

58. Supplementary Figure 5 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
Full Text
View/download PDF

60. Supplementary Table 4 from Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

Author

Kemp, Clinton D., primary, Rao, Mahadev, primary, Xi, Sichuan, primary, Inchauste, Suzanne, primary, Mani, Haresh, primary, Fetsch, Patricia, primary, Filie, Armando, primary, Zhang, Mary, primary, Hong, Julie A., primary, Walker, Robert L., primary, Zhu, Yuelin J., primary, Ripley, R. Taylor, primary, Mathur, Aarti, primary, Liu, Fang, primary, Yang, Maocheng, primary, Meltzer, Paul A., primary, Marquez, Victor E., primary, De Rienzo, Assunta, primary, Bueno, Raphael, primary, and Schrump, David S., primary

Published
2023
Full Text
View/download PDF

62. Data from Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer

Author

Ren, Shun X., primary, Cheng, Alfred S.L., primary, To, Ka F., primary, Tong, Joanna H.M., primary, Li, May S., primary, Shen, Jin, primary, Wong, Clover C.M., primary, Zhang, Lin, primary, Chan, Ruby L.Y., primary, Wang, Xiao J., primary, Ng, Simon S.M., primary, Chiu, Lawrence C.M., primary, Marquez, Victor E., primary, Gallo, Richard L., primary, Chan, Francis K.L., primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Wu, William K.K., primary, and Cho, Chi H., primary

Published
2023
Full Text
View/download PDF

63. Supplementary Figure 1 from Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer

Author

Ren, Shun X., primary, Cheng, Alfred S.L., primary, To, Ka F., primary, Tong, Joanna H.M., primary, Li, May S., primary, Shen, Jin, primary, Wong, Clover C.M., primary, Zhang, Lin, primary, Chan, Ruby L.Y., primary, Wang, Xiao J., primary, Ng, Simon S.M., primary, Chiu, Lawrence C.M., primary, Marquez, Victor E., primary, Gallo, Richard L., primary, Chan, Francis K.L., primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Wu, William K.K., primary, and Cho, Chi H., primary

Published
2023
Full Text
View/download PDF

64. Data from EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

Author

Suvà, Mario-Luca, primary, Riggi, Nicolò, primary, Janiszewska, Michalina, primary, Radovanovic, Ivan, primary, Provero, Paolo, primary, Stehle, Jean-Christophe, primary, Baumer, Karine, primary, Le Bitoux, Marie-Aude, primary, Marino, Denis, primary, Cironi, Luisa, primary, Marquez, Victor E., primary, Clément, Virginie, primary, and Stamenkovic, Ivan, primary

Published
2023
Full Text
View/download PDF

66. Supplementary Figure Legend from Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer

Author

Ren, Shun X., primary, Cheng, Alfred S.L., primary, To, Ka F., primary, Tong, Joanna H.M., primary, Li, May S., primary, Shen, Jin, primary, Wong, Clover C.M., primary, Zhang, Lin, primary, Chan, Ruby L.Y., primary, Wang, Xiao J., primary, Ng, Simon S.M., primary, Chiu, Lawrence C.M., primary, Marquez, Victor E., primary, Gallo, Richard L., primary, Chan, Francis K.L., primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Wu, William K.K., primary, and Cho, Chi H., primary

Published
2023
Full Text
View/download PDF

69. Supplementary Data 2 from EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

Author

Suvà, Mario-Luca, primary, Riggi, Nicolò, primary, Janiszewska, Michalina, primary, Radovanovic, Ivan, primary, Provero, Paolo, primary, Stehle, Jean-Christophe, primary, Baumer, Karine, primary, Le Bitoux, Marie-Aude, primary, Marino, Denis, primary, Cironi, Luisa, primary, Marquez, Victor E., primary, Clément, Virginie, primary, and Stamenkovic, Ivan, primary

Published
2023
Full Text
View/download PDF

71. Supplementary Data 1 from EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

Author

Suvà, Mario-Luca, primary, Riggi, Nicolò, primary, Janiszewska, Michalina, primary, Radovanovic, Ivan, primary, Provero, Paolo, primary, Stehle, Jean-Christophe, primary, Baumer, Karine, primary, Le Bitoux, Marie-Aude, primary, Marino, Denis, primary, Cironi, Luisa, primary, Marquez, Victor E., primary, Clément, Virginie, primary, and Stamenkovic, Ivan, primary

Published
2023
Full Text
View/download PDF

75. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

Author

Fillmore, Christine M., Xu, Chunxiao, Desai, Pooja T., Berry, Joanne M., Rowbotham, Samuel P., Lin, Yi-Jang, Zhang, Haikuo, Marquez, Victor E., Hammerman, Peter S., Wong, Kwok-Kin, and Kim, Carla F.

Subjects
Oncology, Experimental, Gene expression -- Research, Protein research, Cancer -- Care and treatment -- Research, Lung cancer, Non-small cell -- Genetic aspects -- Drug therapy, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Non-small-cell lung cancer is the leading cause of cancer-related death worldwide (1). Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce disease in a minority of patients with this cancer (2,3); therefore, alternative drug targets, including epigenetic enzymes, are under consideration for therapeutic intervention (4). A promising potential epigenetic target is the methyltransferase EZH2, which in the context of the polycomb repressive complex 2 (PRC2) is well known to tri-methylate histone H3 at lysine 27 (H3K27me3) and elicit gene silencing (5). Here we demonstrate that EZH2 inhibition has differential effects on the TopoII inhibitor response of non-small-cell lung cancers in vitro and in vivo. EGFR and BRG1mutations are genetic biomarkers that predict enhanced sensitivity to TopoII inhibitor in response to EZH2 inhibition. BRG1 loss-of-function mutant tumours respond to EZH2 inhibition with increased S phase, anaphase bridging, apoptosis and TopoII inhibitor sensitivity. Conversely, EGFR and BRG1 wild-type tumours upregulate BRG1in response to EZH2 inhibition and ultimately become more resistant to TopoII inhibitor. EGFR gain-of-function mutant tumours are also sensitive to dual EZH2 inhibition and TopoII inhibitor, because of genetic antagonism between EGFR and BRG1. These findings suggest an opportunity for precision medicine in the genetically complex disease of non-small-cell lung cancer., To validate that EZH2 is an important target for non-small-cell lung cancer (NSCLC), we generated a 116-gene lung cancer EZH2 co-expression gene signature (Supplementary Table 1). This signature had predictive [...]

Published
2015

84. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Author

Yap, Damian B., Chu, Justin, Berg, Tobias, Schapira, Matthieu, Cheng, S.-W. Grace, Moradian, Annie, Morin, Ryan D., Mungall, Andrew J., Meissner, Barbara, Boyle, Merrill, Marquez, Victor E., Marra, Marco A., Gascoyne, Randy D., Humphries, R. Keith, Arrowsmith, Cheryl H., Morin, Gregg B., and Aparicio, Samuel A.J.R.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results