157 results on '"Mark O'Neill"'
Search Results
52. An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias
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Fernando O. Campos, Aurel Neic, Caroline Mendonca Costa, John Whitaker, Mark O’Neill, Reza Razavi, Christopher A. Rinaldi, null DanielScherr, Steven A. Niederer, Gernot Plank, and Martin J. Bishop
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Radiological and Ultrasound Technology ,Swine ,Myocardial Infarction ,FOS: Physical sciences ,Arrhythmias, Cardiac ,Health Informatics ,Computer Graphics and Computer-Aided Design ,Physics - Medical Physics ,Cicatrix ,Electrocardiography ,Catheter Ablation ,Tachycardia, Ventricular ,Animals ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical Physics (physics.med-ph) ,Computer Vision and Pattern Recognition - Abstract
Catheter ablation is currently the only curative treatment for scar-related ventricular tachycardias (VTs). However, not only are ablation procedures long, with relatively high risk, but success rates are punitively low, with frequent VT recurrence. Personalized in-silico approaches have the opportunity to address these limitations. However, state-of-the-art reaction diffusion (R-D) simulations of VT induction and subsequent circuits used for in-silico ablation target identification require long execution times, along with vast computational resources, which are incompatible with the clinical workflow. Here, we present the Virtual Induction and Treatment of Arrhythmias (VITA), a novel, rapid and fully automated computational approach that uses reaction-Eikonal methodology to induce VT and identify subsequent ablation targets. The rationale for VITA is based on finding isosurfaces associated with an activation wavefront that splits in the ventricles due to the presence of an isolated isthmus of conduction within the scar; once identified, each isthmus may be assessed for their vulnerability to sustain a reentrant circuit, and the corresponding exit site automatically identified for potential ablation targeting. VITA was tested on a virtual cohort of 7 post-infarcted porcine hearts and the results compared to R-D simulations. Using only a standard desktop machine, VITA could detect all scar-related VTs, simulating activation time maps and ECGs (for clinical comparison) as well as computing ablation targets in 48 minutes. The comparable VTs probed by the R-D simulations took 68.5 hours on 256 cores of high-performance computing infrastructure. The set of lesions computed by VITA was shown to render the ventricular model VT-free. VITA could be used in near real-time as a complementary modality aiding in clinical decision-making in the treatment of post-infarction VTs.
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- 2021
53. Application of SPOD analysis to PIV data obtained in the wake of a circular cylinder undergoing vortex induced vibrations
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Chris Morton, Robert J. Martinuzzi, Moritz Sieber, Christopher Mark O'Neill, and Yannick Schubert
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Physics::Fluid Dynamics ,Vibration ,Physics ,symbols.namesake ,Point of delivery ,Vortex-induced vibration ,symbols ,Cylinder ,Strouhal number ,Mechanics ,Wake ,Vortex shedding ,Vortex - Abstract
Vortex induced vibrations (VIV) of a circular cylinder have been investigated experimentally using a cyberphysical apparatus with m∗ = 8, ζ = 0.005, and Re = 4000. This study considers the application of proper orthogonal decomposition (POD) and spectral POD (SPOD) analysis to the wake dynamics of the low-mass-ratio VIV of a circular cylinder in the lower branch at U∗ = 7.5. SPOD has been previously shown to better separate frequency-centered modal dynamics, compared to POD. Coherent POD and SPOD modes were compared and the newly separated third SPOD mode pair was found to have a periodicity characteristic of vortex shedding and a peak in the temporal coefficient spectra at St = f D/U∞ = 0.2248. The literature has identified that the wake dynamics within the lower branch are synchronized to the cylinder motion; however the present study suggests that some hidden dynamics persist at the Strouhal frequency. Low order models based on the first eight POD and SPOD modes were compared, and it was found that the filtering operation in SPOD removes the uncorrelated stochastic energy component of the POD modes while producing a comparable representation of the coherent deterministic part of the wake dynamics. Using SPOD to separate the distinct frequency-centered dynamics into unique, interpretable mode pairs will simplify future efforts to develop sparse dynamical models of the flow.
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- 2021
54. TLS Proxies: Friend or Foe?
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Mark O'Neill, Scott Ruoti, Kent E. Seamons, and Daniel Zappala
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- 2014
55. Dose‐dependent glycometabolic effects of sotagliflozin on type 1 diabetes over 12 weeks: The inTandem4 trial
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Darren K. McGuire, Mark O'Neill, Frank Mikell, Anne L. Peters, Claire Baker, Phillip Banks, Diane Gesty‐Palmer, Suman Wason, Thomas Danne, Sangeeta Sawhney, Paul Strumph, Anna Chang, and Jake A. Kushner
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Adult ,Male ,medicine.medical_specialty ,Diabetic ketoacidosis ,type 1 diabetes ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Placebo ,Gastroenterology ,Excretion ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Double-Blind Method ,Internal medicine ,randomized trial ,Internal Medicine ,medicine ,Clinical endpoint ,Humans ,Glycosides ,Sodium-Glucose Transporter 2 Inhibitors ,Glycated Hemoglobin ,Type 1 diabetes ,business.industry ,Insulin ,phase 2 study ,SGLT2 inhibitor ,Ketosis ,Original Articles ,Middle Aged ,medicine.disease ,Hypoglycemia ,Diabetes Mellitus, Type 1 ,glycaemic control ,Postprandial ,insulin therapy ,Population study ,Female ,Original Article ,business - Abstract
Aims To assess the dose‐related effects of sotagliflozin, a novel dual inhibitor of sodium‐glucose co‐transporters‐1 and ‐2, in type 1 diabetes (T1D). Materials and methods In this 12‐week, multicentre, randomized, double‐blind, placebo‐controlled dose‐ranging trial, adults with T1D were randomized to once‐daily placebo (n = 36) or sotagliflozin 75 mg (n = 35), 200 mg (n = 35) or 400 mg (n = 35). Insulin was maintained at baseline doses. The primary endpoint was least squares mean (LSM) change in glycated haemoglobin (HbA1c) from baseline. Other endpoints included proportion of participants with ≥0.5% HbA1c reduction and assessments of 2‐hour postprandial glucose (PPG), weight, and urinary glucose excretion (UGE). Results From a mean baseline of 8.0% ± 0.8% (full study population), placebo‐adjusted LSM HbA1c decreased by 0.3% (P = .07), 0.5% (P
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- 2019
56. A Usability Study of Four Secure Email Tools Using Paired Participants
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Daniel Zappala, Justin Wu, Mark O'Neill, Luke Dickinson, Scott Ruoti, Brad Spendlove, Ken Reese, Elham Vaziripour, Tyler Monson, Kent E. Seamons, Jeff Andersen, and Scott Heidbrink
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Government ,General Computer Science ,Computer science ,business.industry ,Internet privacy ,020207 software engineering ,Usability ,02 engineering and technology ,USable ,Grassroots ,Email encryption ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Safety, Risk, Reliability and Quality ,Key management ,business - Abstract
Secure email is increasingly being touted as usable by novice users, with a push for adoption based on recent concerns about government surveillance. To determine whether secure email is ready for grassroots adoption, we employ a laboratory user study that recruits pairs of novice users to install and use several of the latest systems to exchange secure messages. We present both quantitative and qualitative results from 28 pairs of novices as they use Private WebMail (Pwm), Tutanota, and Virtru and 10 pairs of novices as they use Mailvelope. Participants report being more at ease with this type of study and better able to cope with mistakes since both participants are “on the same page.” We find that users prefer integrated solutions over depot-based solutions and that tutorials are important in helping first-time users. Finally, our results demonstrate that Pretty Good Privacy using manual key management is still unusable for novice users, with 9 of 10 participant pairs failing to complete the study.
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- 2019
57. Looking back: understanding visits to museums in the UK and beyond since the nineteenth century
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Mark O'Neill, Astrid Swenson, and Sara Selwood
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Cultural Studies ,History ,DA ,Visual Arts and Performing Arts ,Communication ,05 social sciences ,0211 other engineering and technologies ,Media studies ,050801 communication & media studies ,021107 urban & regional planning ,D204 ,02 engineering and technology ,DC ,0508 media and communications ,DU - Abstract
This editorial introduces the second of two special issues of Cultural Trends dedicated to identifying and interpreting numbers of visits to museums since the nineteenth century. The first exclusively considered UK museums – English museums, in particular. The present issue adds to that coverage of museum visiting in England, Wales and Scotland, as well as addressing visiting in France, Australia and New Zealand. The editorial reflects on the transnational and global dynamics that shaped the development and counting of museum visits.
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- 2019
58. Museum visiting in Edinburgh and Glasgow – 150 years of change and continuity
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Mark O'Neill
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Cultural Studies ,0508 media and communications ,History ,Visual Arts and Performing Arts ,Anthropology ,Communication ,Cultural diversity ,05 social sciences ,0211 other engineering and technologies ,050801 communication & media studies ,021107 urban & regional planning ,02 engineering and technology - Abstract
Despite, or perhaps because of, being only 45 miles apart and of a similar size, Glasgow and Edinburgh are famous for their historical and cultural differences and notorious for their rival...
- Published
- 2019
59. Outcomes for gastrostomy-fed children and their parents: qualitative findings from the 'Your Tube' study
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Janet E Cade, K Horridge, Mark O'Neill, A McCarter, Jo Taylor, Jane Maddison, Bryony Beresford, Lorna K Fraser, and Catherine Hewitt
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Male ,Parents ,Adolescent ,medicine.medical_treatment ,Health Personnel ,MEDLINE ,Complex interventions ,Blended food ,03 medical and health sciences ,0302 clinical medicine ,Enteral Nutrition ,Developmental Neuroscience ,030225 pediatrics ,medicine ,Humans ,Set (psychology) ,Child ,Qualitative Research ,Gastrostomy ,business.industry ,Physical health ,Focus group ,Diet ,Food ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Qualitative research ,Clinical psychology - Abstract
AIM To identify child and parent outcomes relevant to having a gastrostomy, and to specify outcomes believed to be particularly salient to type of diet (formula vs blended food). METHOD Twenty parents, two children (both 12y), and 41 professionals (dietitians [n=10]; nurses [n=12]; paediatricians [n=12]; speech and language therapists [n=7)]) were recruited. Parents and children were interviewed; professionals participated in focus groups. Children (2-18y) represented included those on formula (n=11), blended-food (n=7), and mixed (n=2) diets. All had been tube-fed for at least 6 months. Neurological, genetic, and metabolic conditions were represented. RESULTS Participants identified a range of children's outcomes relevant to a gastrostomy, including physical health, gastrointestinal symptoms, sleep, and time spent feeding. The children described experiences of exclusion caused by being tube-fed. Time, sleep, and emotional health were regarded as most salient to understanding parents' gastrostomy outcomes. Participants believed type of diet would most likely effect gastrointestinal symptoms, time spent feeding, sleep, and physical health. INTERPRETATION Findings indicate a number of refinements to, and allow further specification of, the current 'initial' core outcome set for tube-fed children. Findings also have implications for choice of outcomes measures. Further qualitative research with children and young people is needed. What this paper adds Sleep is a key outcome for children and parents. Gastrointestinal symptoms and physical health were regarded as outcomes most likely to be affected by type of diet. Well-being and participation were identified as key distal outcomes. Gastrostomies are complex interventions. Further specification of the core outcome set is possible.
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- 2021
60. Introduction
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Mark O’Neill, Jette Sandahl, and Marlen Mouliou
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- 2020
61. European Museum of the Year Awards 1977–2019
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Marlen Mouliou, Mark O’Neill, and Jette Sandahl
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- 2020
62. Revisiting Museums of Influence : Four Decades of Innovation and Public Quality in European Museums
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Mark O'Neill, Jette Sandahl, Marlen Mouliou, Mark O'Neill, Jette Sandahl, and Marlen Mouliou
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- European Museum of the Year Award--History, Museums--Europe
- Abstract
Revisiting Museums of Influence presents 50 portraits of a range of European museums that have made striking innovations in public quality over the past 40 years. In so doing, the book demonstrates that excellence can be found in museums no matter their subject matter, scale, or source of funding. Written by leading professionals in the field of museology, who have acted as judges for the European Museum of the Year Award, the portraits describe museums that had, or should have had, an influence on other museums around the world. The portraits aim to capture the moment when this potential was identified, and the introduction will locate the institutions in the wider history of museums in Europe over the period, as well as drawing out common themes of change and innovation that unite the portraits. Providing many very diverse portraits, Revisiting Museums of Influence captures the immense capacity of the museum to respond to changing societal needs. As a result, the book will be essential reading for students of museology and museum professionals around the world in shaping the museums they wish to create. Scholars and students of art history, archaeology, ethnography, anthropology, cultural and visual studies, architecture, memory studies and history will also find much to interest them.
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- 2021
63. Museums and the Repatriation of Objects, 1945–2015
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Mark O’Neill
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- 2017
64. Intra-Atrial Conduction Delay Revealed by Multisite Incremental Atrial Pacing is an Independent Marker of Remodeling in Human Atrial Fibrillation
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Steven E, Williams, Nick W F, Linton, James, Harrison, Henry, Chubb, John, Whitaker, Jaswinder, Gill, Christopher A, Rinaldi, Reza, Razavi, Steven, Niederer, Matthew, Wright, and Mark, O'Neill
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Male ,atrial remodeling ,AF, atrial fibrillation ,S1S2block, the shortest S1S2 coupling interval that conducts from pacing site to left atrium ,ΔEV, rate dependence of electrogram voltage ,AF substrate ,Electrocardiography ,Heart Conduction System ,HRA, high right atrium ,Atrial Fibrillation ,LA, left atrial ,Humans ,atrial fibrillation ,cardiovascular diseases ,Heart Atria ,Aged ,PAF, paroxysmal AF ,ADT, activation dispersion time ,ΔED, rate dependence of electrogram duration ,Cardiac Pacing, Artificial ,Middle Aged ,CS, coronary sinus ,ERP, effective refractory period ,Pulmonary Veins ,S1S2delay, the shortest S1S2 coupling interval conducting without decrement to the left atrium ,ED, electrogram duration ,EV, electrogram voltage ,cardiovascular system ,Female ,New Research Paper ,Electrophysiologic Techniques, Cardiac ,electrophysiology testing - Abstract
Objectives This study sought to characterize direction-dependent and coupling interval–dependent changes in left atrial conduction and electrogram morphology in uniformly classified patients with paroxysmal atrial fibrillation (AF) and normal bipolar voltage mapping. Background Although AF classifications are based on arrhythmia duration, the clinical course, and treatment response vary between patients within these groups. Electrophysiological mechanisms responsible for this variability are incompletely described. Methods Intracardiac contact mapping during incremental atrial pacing was used to characterize atrial conduction, activation dispersion, and electrogram morphology in 15 consecutive paroxysmal AF patients undergoing first-time pulmonary vein isolation. Outcome measures were vulnerability to AF induction at electrophysiology study and 2-year follow-up for arrhythmia recurrence. Results Conduction delay showed a bimodal distribution, occurring at either long (high right atrium pacing: 326 ± 13 ms; coronary sinus pacing: 319 ± 16 ms) or short (high right atrium pacing: 275 ± 11 ms; coronary sinus pacing: 271 ± 11 ms) extrastimulus coupling intervals. Arrhythmia recurrence was found only in patients with conduction delay at long extrastimulus coupling intervals, and patients with inducible AF were characterized by increased activation dispersion (activation dispersion time: 168 ± 29 ms vs. 136 ± 11 ms). Electrogram voltage and duration varied throughout the left atrium, between patients, and with pacing site but were not correlated with AF vulnerability or arrhythmia recurrence. Conclusions Within the single clinical entity of paroxysmal AF, incremental atrial pacing identified a spectrum of activation patterns correlating with AF vulnerability and arrhythmia recurrence. In contrast, electrogram morphology (characterized by electrogram voltage and duration) was highly variable and not associated with AF vulnerability or recurrence. An improved understanding of the electrical phenotype in AF could lead to improved mechanistic classifications., Graphical abstract
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- 2017
65. Introduction
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Mark O’Neill
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- 2019
66. I Don't Even Have to Bother Them!
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Daniel Zappala, Jake Tyler, Justin Wu, Mark O'Neill, Elham Vaziripour, Kent E. Seamons, and Devon Howard
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Authentication ,Distrust ,business.industry ,Computer science ,media_common.quotation_subject ,Internet privacy ,SIGNAL (programming language) ,Service provider ,Encryption ,Ceremony ,Authentication (law) ,Secure messaging ,Social media ,business ,media_common - Abstract
The privacy guaranteed by secure messaging applications relies on users completing an authentication ceremony to verify they are using the proper encryption keys. We examine the feasibility of social authentication, which partially automates the ceremony using social media accounts. We implemented social authentication in Signal and conducted a within-subject user study with 42 participants to compare this with existing methods. To generalize our results, we conducted a Mechanical Turk survey involving 421 respondents. Our results show that users found social authentication to be convenient and fast. They particularly liked verifying keys asynchronously, and viewing social media profiles naturally coincided with how participants thought of verification. However, some participants reacted negatively to integrating social media with Signal, primarily because they distrust social media services. Overall, automating the authentication ceremony and distributing trust with additional service providers is promising, but this infrastructure needs to be more trusted than social media companies.
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- 2019
67. Author response for 'Dose‐Dependent Glycometabolic Effects of Sotagliflozin on Type 1 Diabetes Over 12 Weeks: the inTandem4 Trial'
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Phillip Banks, Sangeeta Sawhney, Darren K. McGuire, Diane Gesty‐Palmer, Anna Chang, Thomas Danne, Anne L. Peters, Paul Strumph, Frank Mikell, Suman Wason, Jake A. Kushner, Mark O'Neill, and Claire Baker
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medicine.medical_specialty ,Type 1 diabetes ,business.industry ,Internal medicine ,Dose dependence ,Sotagliflozin ,medicine ,business ,medicine.disease - Published
- 2019
68. Impact of evidence-based stroke care on patient outcomes : A multilevel analysis of an international study
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Paula Muñoz Venturelli, Xian Li, Sandy Middleton, Caroline Watkins, Pablo M. Lavados, Verónica V. Olavarría, Alejandro Brunser, Octavio Pontes‐Neto, Taiza E. G. Santos, Hisatomi Arima, Laurent Billot, Maree L. Hackett, Lily Song, Thompson Robinson, Craig S. Anderson, Gillian Mead, H. Asita De Silva, Jeyaraj D. Pandian, Ruey‐Tay Lin, Tsong‐Hai Lee, Liying Cui, Bin Peng, Stephane Heritier, Richard Lindley, Stephen Jan, Elizabeth Boaden, Christopher P. L. H. Chen, Anne Forster, Mark Woodward, Kris Rogers, Anish Scaria, Joyce Y. Lim, Natalie Espinosa, Lucy McEvoy, Lee Blackburn, Sarah S. Richtering, Shoujiang You, Simon Ladwig, Gabrielle P. Merritt, Bryce Thomsen, Kerry Jenson, Penelope Gordon, Dennis Ryan Nguyen, Wei Wei Quan, Tessa Pei‐Yi Lo, Jonathan Lim, Selena Goh, Leibo Liu, Mirza Ahmad Baig, Ravider Singh, Paul Donnelly, Manuela Armenis, Marna Van Zyl, Helen Monaghan, Phillipa Smith, Parisa Glass, Fanli Zhou, Yun Shen, Li Lei, Di Li, Ting Zhang, Xiaoyan Zhang, Yun Peng, Lingling Feng, Zhiping Ye, Philip Gregory, Jeyaraj D. Pandain, Deepti Arora, Francisca Gonzalez, Bernardita Portales, Taiza Santos‐Pontelli, Brunna Rimoli, Monica Braga, Carolina Vidal, Dafna Benadof, Rodrigo J. Rivas, Laura Carvallo, Pamela Carvallo, Rubia Miranda, Brunna Pileggi, H. Asita de Silva, Shalomi Weerawardena, Thanushanthan Jeevarajah, Devaki Dharmawardena, Dumindi Ranasinghe, Matheesha Dharshana, Nilesh Nandadeva, Savithri Nawarathna, Jiu‐Haw Yin, Shoou‐Jeng Yeh, Ruei‐Jen Ma, Caroline L. Watkins, Gemma Whiteley, Denise Forshaw, Catherine Elizabeth Lightbody, Joanna Cox, Jane Fitzgerald, John F. Heney, Helen Byfield, Simone Finley, Hayley E. Tyrer, Carole Bruce, Alison Gibbon, Brett Jones, Emma Siracusa, Koushik Gowda, Shahla Cowans, Briana Forman, Sherin Jacob, Kristine Caprecho, Roshan Khatri, Po Yi Wan, Maria Lopez, Sifiso Vanika, Wilhelmina Bleeker, Marinka Ireland, Sheila Jala, Susan Day, Eric Ha, Martin Krause, Melissa Passer, Sarah Giaccari, Nadia Burkolter, Michael Braithwaite, Kylie Tastula, Darshan Ghia, Tapuwa Musuka, Anthony Alvaro, Gillian Edmonds, Nicole O'Loughin, Rebecca Phair, Joanne Kaoutal, David J. Blacker, Belinda L Saint, Kim Parrey, Michelle Coad, Matthew Kinchington, Nishantha Senanayake, Johanna Alaban, Irma Kuehne, Millene Camilo, Milena Libardi, Sheila Martins, Batista Carlos, Magda Martins, Leonardo Carbonera, Andrea Almeida, Martin Kelin, Carla Pauli, Mariana Lunardi, Luciane Silveira, Olga Chagas, Daily Souza, Gabriel Braga, Priscila Ribeiro, Gustavo Luvizutto, Marcia Polin, Fernanda Winckler, Jinfeng Liu, Zhenjiang Wang, Huibing Wang, Suying Lin, Jing Dong, Junshan Zhou, Suping Qin, Hui Zhan, Yongquan Xue, Dong Tian, Dan Yang, Yan Yin, He Li, Changming Geng, Jieyi Liu, Xiaolin Jiang, Yujun Wu, Wei Sun, Bingqi Yu, Yanmei Guan, Qin Wang, Bo Wei, Huirong Wang, Yan Wang, Liwen Tai, Wenchao Zhang, Weili Zhao, Xueying Wang, Guoli Li, Zhiming Ni, Fudong Guo, Lan Cen, Jun Lu, Zheng Chen, Guoming Yin, Yingchun Wang, Jiping Zheng, Zhimin Zhou, Hongquan Wang, Renlin Zou, Bin Xue, Airu Li, Jing Guo, Ying Guo, Xingguo Jiang, Xiuge Tan, Chunpeng Zhang, Bei Shao, Xiaoting Niu, Chunfeng Liu, Dongqin Chen, Ping Liang, Xia Zhang, Chunqing Zhang, Wenjie Gong, Zhichao Huang, Huihui Liu, Junying Huang, Rongfang Shi, Cuilan Wang, Ying Liu, Jinchao Wang, Guojun Wu, Zhihong Gao, Qunli Lin, Cong Xu, Huile Zheng, Xinghai Ye, Xiaoqiong Jin, Junyan Liu, Xiaoyun Cao, Yan Zhang, Jinyang Wang, Yuzhu Xu, Yan Li, Xin Ma, Qi Kong, Yanlei Hao, Baojun Qiao, Hui Yan, Zhiyong Huang, Baoqiang Chang, Jinjin Yan, Pinjun Liao, Wei Zhang, Ling Liu, Tingting Zhu, Xuehui Liu, Yongping Li, Ruifang Dong, Miao Chen, Xiaoli Ge, Hairong Wang, Lihua Dai, Jiafu Liu, Shixia Wang, Jihui Du, Aixiu Song, Yunhai Li, Jie Feng, Cheng Yu, Honglin Feng, Xiaojia Sun, Ruihong Sun, Weisong Liu, Jianfeng Liu, Xuesheng Lu, Enzhuo Chen, Wei Gao, Hui Liu, Heping Wang, Yanxia Wang, Juan Song, Dongqi Liu, Wenhui Du, Guixia Li, Cuiling Li, Yanling Liang, Xuekun Cai, Jinli Zhang, Xiaowei Tao, Pingshun An, Ranran Tang, Xu Qin, Yingling Wang, Wenjun Zhang, Rong Ma, Xiaoqiong Huang, Yonglin Liu, Yazhi Wang, Ping Fan, Hailan Yang, Lianyuan Feng, Jianxia Zhi, Jiewen Zhang, Yao Zhou, Danhong Wu, Haiyan He, Xiaohong Chen, Yongge Hou, Xiaohui Su, Siyuan Fan, Luis Suárez, Juan de Dios Polanco, Patricio Sotomayor, Ricardo Urzúa, Daniela Urrutia, Nathalie Conejan, Arturo Escobar, Monica Gonzalez, Danisa Vargas, Angel Constante, Erika Vásquez, Elizabeth Godoy, Christian Figueroa, Vanesa San Martin, Nataly Vidal, Madeleyn Muñoz, María Spencer, Juan Almeida, Ignacio Acosta, Rodrigo Guerrero, Prudencio Lozano, Camila Aguayo, Jimena Pizarro, Alvaro Soto, Flor Bonilla, Pía García, Carolina Del Castillo, Marcela Grandjean, Alexis Von Johnn, Ignacio Gutierrez, Francisca Rivero, Ignacio López, Federico Silva, Marlen Pachón, José Mendoza, Alexander Pabón, Mahesh Kate, Naushad Akhtar, Gibbsdeep S. Narang, Ashish Deepak, Vikram Huded, Romnesh De Sowza, Alben Sigamani, Karthikeyan Rajendran, Anisha Vishwanath, Anusha K, Somasundaram Kumaravelu, Syed Rahamath, Sandeep Kannneganti, Dheeraj Khurana, Cheena Katoch, Taranpreet Kaur, Ummer Karadan, Anu Kuriakose, Jaison John, Mumthaz Basheer, Harsha Hemal Gunasekara, Gamlath Chandima Udeni De Silva, Peetagam Harshi Lakmali Ubeywickrama, Kavisha Chathumali Silva, Eshani Anuradha De Silva, Udaya Ranawaka, Chamila Mettananda, Yamuna Nanayakkara, Tharini Mendis, Gayathri Fernando, Ahamed Imthikab, Kandula Pieris, Saman B. Gunatilake, Pamuditha M. W. Madanayake, Shiran A. Paranavitane, Bimsara Senanayake, Vaidhehi Vishwanathan, Maathury Sivapalan, Ruwangi U. Murage, Uthpala Chandradeva, Yao‐Hua Liu, Chih‐Lung Lin, Hsiu‐Fen Lin, Kuan‐Ting Liu, Chien‐Fu Chen, Meng‐Ni Wu, Su‐Hua Tsai, Chi‐Ching Chen, Lan‐Yi Chen, Chien‐Hung Chang, Yeu‐Jhy Chang, Kuo‐Lun Huang, Ting‐Yu Chang, Chi‐Hung Liu, Chen‐June Seak, Yu‐Li Lin, Jia‐Yi Luo, Hsiao‐Ying Yang, Ching‐Yi Wang, Lung Chan, Chaur‐Jong Hu, Nai‐Fang Chi, Dean Wu, Yao‐Hsien Huang, Yi‐Chun Kuan, Chien‐Tai Hong, Yi‐Chun Chen, Yu Sun, Cheng‐Huai Lin, Chien‐Jung Lu, Hai‐Jui Chu, Yi‐Chia Lo, Wen‐Hui Chang, Wan‐Jung Lin, Hui‐Chen Su, Tien‐Yu Lin, Chi‐Hsuan Cho, Shu‐Lan Lu, Ya‐Fang Hsueh, Ching‐Yi Lai, David Jarrett, Claire James, Stacey Valentine, Clare Whistler, Rebecca Butler, Simone Browning, Caroline Watchurst, Renuka Erande, Emma Elliott, Krishna Patel, Maria Brezitski, Caroline Hogan, Asra Banaras, Lucinda Crook, Rashidat Ahmed, Lindsay Potter, Rosie Laird, Natasha Clarke, Alison Loosemore, J. Godber, Sara Gawned, K. A. Hamilton, Rachael Jones, Paul Guyler, Sharon Tysoe, Raji Prabakaran, Sweni Shah, Joanne Calver, Laszlo K. Sztriha, Maria Fitzpatrick, Stephanie Drysdale, John Aeron‐Thomas, Emma McKenzie, Belinda Chitando, Paul Willcoxson, Elizabeth Iveson, Peter Wanklyn, Natasha Dyer, Michael Keeling, Romina Rodriguez, Kerry Elliott, Mia Porteous, Mark O'Neill, Sheridan Orme, Carla Richardson, Janet Tomlinson, Suzanne Hawkins, Delia Bester, Carol Jeffs, Joanne Howard, Pauline Brown, Deborah Ward, Jennifer Turfrey, Leanne Raybould, Allison Bates, Sue O'Connell, Margaret O'Connor, Samantha Williams, Hedley C. A. Emsley, Alison McLoughlin, Sonia Raj, Bindu Gregary, Donna Doyle, G. M. Courtauld, C. Schofield, L. Lucas, A. Lydon, A. James, Kari Saastamoinen, Laura Howaniec, Premchand Daboo, Ali N. Ali, Emma Richards, Joanne Howe, Christine Kamara, Kathy Stocks, Ralf Lindert, Diana J. Day, Sarah Finlay, Joanne McGee, Jennifer Mitchell, Elaine Amis, Rosemary Macey, Suzanne Tauro, Lauren Henry, Sarah Cuddy, Andrew Steele, Kerry Mullen, Sarah Kirker, Murudappa Bhattad, Michael Carpenter, Prabal Datta, Ann Needle, Linda Jackson, Julie Ball, Rosie Beckitt, Nicola Chivers, Angela Bowring, Sara Eddy, Kevin Thorpe, Samantha Keenan, Alison Griffin, Stuart Maguire, Chris Patterson, Hawraman Ramadan, Ruth Bellfield, Michaela Hooley, Kelvin Stewart, Lucy Williams, Cara Gurney, Deborah Oliver, Maria Gardiner, Sarah Grayland, Mohit Bhandari, David M. Collas, Tolu Adesina, Saul Sundayi, Ruth Harvey, Emma Pope, Audrey Lam, Elaine Walker, Colin Merrill, Soma Banerjee, Kirsten Hannah Harvey, Sheila Mashate, Peter Wilding, Linda Johnson, Robert Namushi, Patricia Jacob, Sreeman Andole, Karen Dunne, Naveen Gadapa, Sam King, Sonata Siliuzaite, Sharon Dealing, Karen Attwood, Annette Woods, Banher Sandhu, Maam Mamun, Afzal Mahmood, June Jones, Abimbola Ojo, Denise Carter‐Evans, Royal Liverpool, Aravind Manoj, Glyn Fletcher, Paula Lopez, Jill Greig, Matthew Robinson, Sarah Jones, Lorinda Jones, Claire West, Helen Tench, Rachel Gascoyne, Amanda Whileman, Emily Hall, Stephanie Wright, Julie Toms, Duke Phiri, Sakthivel Sethuraman, Niaz Mohammed, Frances Justin, Margaret Louise Tate, Meena Chauhan, Syed I. Haider, Arumugam Nallasivan, Tim Webster, Sandra Leason, Samantha Seagrave, Peterborough City Hospital, Peter Owksu‐Agyei, Natalie Temple, Nicola Butterworth‐Cowin, Frederick Magezi, Leicester Royal Infirmary, Shagufta Khan, Claire Stephens, Amit Mistri, Aidan Murphy, Manda Lam, Paul Underwood, Catherine Thompson, Clare Buckley, Diane Wood, Sarah Board, Linda Howard, Ashraf Ahmed, Bethany Oates, Sara Leonard, Royal Bournemouth Hospital, Royal Bournemouth, Kamy Thavanesan, Michelle Dharmasiri, Sathyabama Logianathan, Catherine Ovington, Gail Hann, Chantel Cox, Craigavon Area Hospital, Southern Health, Social Care Trust, Catherine Douglas, Michael Goggin, Patricia Fearon, Sara Gilpin, Margaret O'Hagan, Pilgrim Hospital, Anne Hardwick, Kimberley Netherton, Judith Quinn, Tulu Bozkaplan, Josin Jose, Univ New South Wales, Ctr Estudios Clin, Clin Alemana Univ Desarrollo, Peking Univ, Australian Catholic Univ, Univ Cent Lancashire, Univ Chile, Universidade de São Paulo (USP), Fukuoka Univ, Univ Leicester, Univ Edinburgh, George Inst Global Hlth, Univ Desarrollo, St Vincents Hlth Australia Sydney, Univ Kelaniya, Christian Med Coll & Hosp, Kaohsiung Med Univ & Hosp, Linkou Chang Gung Mem Hosp, Peking Union Med Coll Hosp, Monash Univ, Natl Univ Singapore, Bradford Royal Infirm, Christian Med College, RemediumOne Pvt Ltd, Kaohsiung Med Univ, Calvary Publ Hosp Bruce, Royal North Shore Hosp, Royal Prince Alfred Hosp, Concord Repatriat Gen Hosp, Fiona Stanley Hosp, Macquarie Base Hosp, Hosp Governador Celso Ramos, Universidade Estadual Paulista (Unesp), Yangquan Coalmine Grp Gen Hosp, Nanjing Med Univ, 85 Hosp Peoples Liberat Army, Chifeng Univ, Beijing Pinggu Hosp, Wenzhou Med Univ, Soochow Univ, Hebei Med Univ, Capital Med Univ, Jining Med Univ, Third Peoples Hosp Huizhou, Second Cangzhou Cent Hosp, Shanghai Jiao Tong Univ, Baogang Hosp, Harbin Med Univ, Shanghai Jiao Tong Univ Sch, Guangzhou Med Univ, Second Hosp Nanchang, Bethune Int Peace Hosp, Hua Henan Prov Peoples Hosp, Shijiazhuang Cent Hosp, Hosp Base San Jos de Osorno, Unit Narayana Hrudayalaya Ltd, Dr Ramesh Cardiac & Multispecial Hosp Pvt Ltd, Post Grad Inst Med Educ & Res, Baby Mem Hosp Ltd, Sree Chitra Tirunal Inst Med Sci & Technol, Sri Jayawardenepura Gen Hosp, Colombo North Teaching Hosp, Colombo South Coching Hosp, Taipei Med Univ, En Chu Kong Hosp, Natl Cheng Kung Univ Hosp, Queen Alexandra Hosp, Portsmouth Hosp NHS Natl Hlth Serv iTrust, Univ Coll London Hosp NHS Fdn Trust, Univ Hosp Birmingham NHS Fdn Trust, Southend Univ Hosp NHS Fdn Trust, Kings Coll Hosp London, York Teaching Hosp NHS Fdn Trust, Nottingham Univ Hosp NHS Trust, Blackpool Teaching Hosp NHS Fdn Trust, Gloucestershire Hosp NHS Fdn Trust, Teaching Hospi NHS Fdn Trust, Royal Cornwall Hosp NHS Trust, Royal London Hosp, Sheffield Teaching Hosp NHS Fdn Trust, Cambridge Univ Hosp NHS Fdn Trust, Royal Victoria Hosp, Pinderfields Gen Hosp, Royal Devon & Exeter NHS Fdn Trust, Bradford Teaching Hosp NHS Fdn Trust, Great Western Hosp NHS Fdn Trust, Watford Dist Gen Hosp, Imperial Coll Healthcare NHS Trust, Medway NHS Fdn Trust, Royal Liverpool & Broadgreen Univ NHS Trust, Calderdale & Huddersfield NHS Fdn Trust, Hywel Dda Univ Hlth Board, Chesterfield Royal Hosp NHS Fdn Trust, Luton & Dunstable Univ Hosp NHS Fdn Trust, Countess Chester Hosp NHS Fdn Trust, Peterborough City Hosp, Univ Hosp Leicester NHS Trust, Dist Hosp NHS Fdn Trust, Barnsley Hosp NHS Fdn Trust, Dorset Cty Hosp NHS Fdn Trust, Royal Bournemouth & Christchurch Hosp NHS Fdn Tru, Southern Hlth & Social Care Trust, United Lincolnshire Hosp NHS Trust, and Bedford Hosp NHS Trust
- Subjects
Male ,Stroke care ,Brain Ischemia ,0302 clinical medicine ,Atrial Fibrillation ,Clinical Studies ,Thrombolytic Therapy ,030212 general & internal medicine ,Acute ischemic stroke ,Stroke ,Thrombectomy ,Original Research ,Aged, 80 and over ,Evidence-Based Medicine ,Quality and Outcomes ,Multilevel model ,Middle Aged ,16. Peace & justice ,3. Good health ,Outcome and Process Assessment, Health Care ,quality ,outcome ,Female ,multilevel analysis ,Cardiology and Cardiovascular Medicine ,China ,medicine.medical_specialty ,Evidence-based practice ,Taiwan ,India ,Patient Positioning ,03 medical and health sciences ,medicine ,Humans ,Intensive care medicine ,Antihypertensive Agents ,Physical Therapy Modalities ,Aged ,Sri Lanka ,Ischemic Stroke ,business.industry ,Australia ,Anticoagulants ,South America ,A300 ,Process of care ,medicine.disease ,United Kingdom ,Logistic Models ,acute stroke care ,Cerebrovascular Disease/Stroke ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Deglutition Disorders ,business ,Platelet Aggregation Inhibitors ,030217 neurology & neurosurgery - Abstract
Made available in DSpace on 2019-10-04T12:41:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-02 National Health and Medical Research Council of Australia Background-The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence-based processes of care for acute ischemic stroke (AIS) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stroke Trial), a multicenter cluster crossover trial of lying flat versus sitting up, head positioning in acute stroke. Methods and Results-Use of 8 AIS processes of care were considered: reperfusion therapy in eligible patients; acute stroke unit care; antihypertensive, antiplatelet, statin, and anticoagulation for atrial fibrillation; dysphagia assessment; and physiotherapist review. Hierarchical, mixed, logistic regression models were performed to determine associations with good outcome (modified Rankin Scale scores 0-2) at 90 days, adjusted for patient and hospital variables. Among 9485 patients with AIS, implementation of all processes of care in eligible patients, or defect-free care, was associated with improved outcome (odds ratio, 1.40; 95% CI, 1.18-1.65) and better survival (odds ratio, 2.23; 95% CI, 1.62-3.09). Defect-free stroke care was also significantly associated with excellent outcome (modified Rankin Scale score 0-1) (odds ratio, 1.22; 95% CI, 1.04-1.43). No hospital characteristic was independently predictive of outcome. Only 1445 (15%) of eligible patients with AIS received all processes of care, with significant regional variations in overall and individual rates. Conclusions-Use of evidence-based care is associated with improved clinical outcome in AIS. Strategies are required to address regional variation in the use of proven AIS treatments. Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia Ctr Estudios Clin, Inst Ciencias & Innovac Med, Santiago, Chile Clin Alemana Univ Desarrollo, Fac Med, Serv Neurol, Dept Neurol & Psiquiatria, Santiago, Chile Peking Univ, Hlth Sci Ctr, George Inst Global Hlth, Beijing, Peoples R China Australian Catholic Univ, Nursing Res Inst, St Vincents Hlth Australia Sydney, Sydney, NSW, Australia Univ Cent Lancashire, Fac Hlth & Wellbeing, Preston, Lancs, England Univ Chile, Fac Med, Dept Ciencias Neurol, Santiago, Chile Univ Sao Paulo, Ribeirao Preto Med Sch, Stroke Serv Neurol Div, Ribeirao Preto, Brazil Fukuoka Univ, Fac Med, Dept Prevent Med & Publ Hlth, Fukuoka, Fukuoka, Japan Univ Leicester, Dept Cardiovasc Sci, Leicester Biomed Res Ctr, Leicester, Leics, England Univ Leicester, Natl Inst Hlth Res, Leicester Biomed Res Ctr, Leicester, Leics, England Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland George Inst Global Hlth, Sydney, NSW, Australia Univ Desarrollo, Serv Neurol, Dept Neurol & Psiquiatria Clin Alemana Santiago, Santiago, Chile St Vincents Hlth Australia Sydney, Sydney, NSW, Australia Australian Catholic Univ, Sydney, NSW, Australia Univ Cent Lancashire, Stroke Practice Res Unit, Sch Hlth, Lancashire Clin Trials Unit, Preston, Lancs, England Univ Leicester, Dept Cardiovasc Sci, Cardiovasc Res Ctr, British Heart Fdn, Leicester, Leics, England Univ Kelaniya, Dept Pharmacol, Fac Med, Colombo, Sri Lanka Christian Med Coll & Hosp, Dept Neurol, Ludhiana, India Kaohsiung Med Univ & Hosp, Dept Neurol, Kaohsiung, Taiwan Linkou Chang Gung Mem Hosp, Dept Neurol, Taipei, Taiwan Peking Union Med Coll Hosp, Beijing, Peoples R China Univ Sao Paulo, Ribeirao Preto Sch Med, Ribeirao Preto, Brazil Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia Univ Cent Lancashire, Sch Hlth Sci, Coll Hlth & Wellbeing, Preston, Lancs, England Univ Desarrollo, Santiago, Chile Univ New South Wales, Neurosci Res Australia, Sydney, NSW, Australia Natl Univ Singapore, Dept Pharmacol, Singapore, Singapore Bradford Royal Infirm, Bradford Inst Hlth Res, Leeds, W Yorkshire, England Christian Med College, Ludhiana, Punjab, India RemediumOne Pvt Ltd, Kandy, Sri Lanka Kaohsiung Med Univ, Chung Ho Mem Hosp, Kaohsiung, Taiwan Calvary Publ Hosp Bruce, Bruce, Australia Royal North Shore Hosp, St Leonards, NSW, Australia Royal Prince Alfred Hosp, Camperdown, NSW, Australia Concord Repatriat Gen Hosp, Camperdown, NSW, Australia Fiona Stanley Hosp, Camperdown, NSW, Australia Macquarie Base Hosp, Melbourne, Vic, Australia Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin, Sao Paulo, Brazil Hosp Governador Celso Ramos, Florianopolis, SC, Brazil Sao Paulo State Univ, Hosp Fac Med Botucatu, UNESP, Sao Paulo, Brazil Yangquan Coalmine Grp Gen Hosp, Yangquan, Peoples R China Nanjing Med Univ, Nanjing Hosp 1, Nanjing, Jiangsu, Peoples R China 85 Hosp Peoples Liberat Army, Beijing, Peoples R China Chifeng Univ, Affiliated Hosp, Chifeng, Peoples R China Beijing Pinggu Hosp, Beijing, Peoples R China Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China Soochow Univ, Affiliated Hosp 2, Suzhou, Peoples R China Hebei Med Univ, Hosp 3, Shijiazhuang, Hebei, Peoples R China Capital Med Univ, Xuanwu Hosp, Beijing, Peoples R China Jining Med Univ, Affiliated Hosp, Jining, Peoples R China Third Peoples Hosp Huizhou, Huizhou, Peoples R China Second Cangzhou Cent Hosp, Cangzhou, Peoples R China Shanghai Jiao Tong Univ, Hosp Affiliated, Sch Med, Shanghai, Peoples R China Baogang Hosp, Baotou, Peoples R China Harbin Med Univ, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China Shanghai Jiao Tong Univ Sch, Tong Ren Hosp, Peoples Hosp Hejian City, Shanghai, Peoples R China Peking Univ, Shougang Hosp, Beijing, Peoples R China Guangzhou Med Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China Second Hosp Nanchang, Nanchang, Jiangxi, Peoples R China Bethune Int Peace Hosp, Beijing, Peoples R China Hua Henan Prov Peoples Hosp, Beijing, Peoples R China Hua Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Ninth Peoples Hosp, Shanghai, Peoples R China Shijiazhuang Cent Hosp, Shijiazhuang, Hebei, Peoples R China Hosp Base San Jos de Osorno, Osorno, Chile Christian Med Coll & Hosp, Ludhiana, Punjab, India Unit Narayana Hrudayalaya Ltd, Mazumdar Shaw Med Ctr, Bangalore, Karnataka, India Dr Ramesh Cardiac & Multispecial Hosp Pvt Ltd, Guntur, India Post Grad Inst Med Educ & Res, Chandigarh, India Baby Mem Hosp Ltd, Calicut, Kerala, India Sree Chitra Tirunal Inst Med Sci & Technol, Thiruvananthapuram, Kerala, India Sri Jayawardenepura Gen Hosp, Sri Jayawardenepura Kott, Sri Lanka Colombo North Teaching Hosp, Colombo, Sri Lanka Colombo South Coching Hosp, Colombo, Sri Lanka Linkou Chang Gung Mem Hosp, Taoyuan, Taiwan Taipei Med Univ, Shuang Ho Hosp, Taipei, Taiwan En Chu Kong Hosp, New Taipei, Taiwan Natl Cheng Kung Univ Hosp, Tainan, Taiwan Queen Alexandra Hosp, Portsmouth, Hants, England Portsmouth Hosp NHS Natl Hlth Serv iTrust, Portsmouth, Hants, England Univ Coll London Hosp NHS Fdn Trust, London, England Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp Birmingham, Birmingham, W Midlands, England Southend Univ Hosp NHS Fdn Trust, Southend On Sea, England Kings Coll Hosp London, London, England York Teaching Hosp NHS Fdn Trust, York, N Yorkshire, England Nottingham Univ Hosp NHS Trust, Nottingham, England Blackpool Teaching Hosp NHS Fdn Trust, Blackpool, England Gloucestershire Hosp NHS Fdn Trust, Gloucestershire Royal Hosp, Gloucester, England Teaching Hospi NHS Fdn Trust, London, England Royal Cornwall Hosp NHS Trust, Truro, England Royal London Hosp, Barts Hlth NHS Trust, London, England Sheffield Teaching Hosp NHS Fdn Trust, Sheffield, S Yorkshire, England Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge, England Royal Victoria Hosp, Belfast Hlth & Social Care Trust, London, England Pinderfields Gen Hosp, Mid Yorkshire Hosp NHS Trust, Wakefield, England Royal Devon & Exeter NHS Fdn Trust, London, England Bradford Teaching Hosp NHS Fdn Trust, Bradford, W Yorkshire, England Great Western Hosp NHS Fdn Trust, Swindon, Wilts, England Watford Dist Gen Hosp, Watford, England Imperial Coll Healthcare NHS Trust, London, England Medway NHS Fdn Trust, Gillingham, England Royal Liverpool & Broadgreen Univ NHS Trust, Liverpool, Merseyside, England Calderdale & Huddersfield NHS Fdn Trust, Huddersfield, W Yorkshire, England Hywel Dda Univ Hlth Board, Haverfordwest, Wales Chesterfield Royal Hosp NHS Fdn Trust, Calow, England Luton & Dunstable Univ Hosp NHS Fdn Trust, Luton, Beds, England Countess Chester Hosp NHS Fdn Trust, Chester, Cheshire, England Peterborough City Hosp, Peterborough, Cambs, England Univ Hosp Leicester NHS Trust, Leicester Royal Infirm, Leicester, Leics, England Dist Hosp NHS Fdn Trust, London, England Barnsley Hosp NHS Fdn Trust, Barnsley, England Dorset Cty Hosp NHS Fdn Trust, Dorchester, England Royal Bournemouth & Christchurch Hosp NHS Fdn Tru, Royal Bournemouth Hosp, Bournemouth, Dorset, England Southern Hlth & Social Care Trust, Craigavon Area Hosp, Portadown, England United Lincolnshire Hosp NHS Trust, Pilgrim Hosp, Lincoln, England Bedford Hosp NHS Trust, Bedford, England Sao Paulo State Univ, Hosp Fac Med Botucatu, UNESP, Sao Paulo, Brazil National Health and Medical Research Council of Australia: 1066966
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- 2019
69. Modelling left atrial flow, energy, blood heating distribution in response to catheter ablation therapy
- Author
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Desmond, Dillon-Murphy, David, Marlevi, Bram, Ruijsink, Ahmed, Qureshi, Henry, Chubb, Eric, Kerfoot, Mark, O'Neill, David, Nordsletten, Oleg, Aslanidi, and Adelaide, de Vecchi
- Subjects
thermal modeling ,lcsh:QP1-981 ,Physiology ,catheter ablation ,atrial fibrillation ,computational fluid dynamics ,lcsh:Physiology ,Original Research ,left atrium - Abstract
INTRODUCTION: Atrial fibrillation (AF) is a widespread cardiac arrhythmia that commonly affects the left atrium (LA), causing it toquiver instead of contracting effectively. This behavior is triggered by abnormal electrical impulses at a specific site in the atrial wall. Catheter ablation (CA) treatment consists of isolating this driver site by burning the surrounding tissue to restore sinus rhythm (SR). However, evidence suggests that CA can concur to the formation of blood clots by promoting coagulation near the heat source and in regions with low flow velocity and blood stagnation.METHODS: A patient-specific modelling workflow was created and applied to simulate thermal-fluid dynamics in two patients pre- and post-CA. Each model was personalised based on pre- and post-CA imaging datasets. The wall motion and anatomy were derived from SSFP Cine MRI data, while the trans-valvular flow was based on Doppler ultrasound data. The temperature distribution in the blood was modelled using a modified Pennes bioheat equation implemented in a finite-element based Navier-Stokes solver. Blood particles were also classified based on their residence time in the LA using a particle-tracking algorithm.RESULTS: SR simulations showed multiple short-lived vortices with an average blood velocity of 0.2-0.22 m/s. In contrast, AF patients presented a slower vortex and stagnant flow in the LA appendage, with the average blood velocity reduced to 0.08-0.14 m/s. Restoration of SR also increased the blood kinetic energy and the viscous dissipation due to the presence of multiple vortices. Particle tracking showed a dramatic decrease in the percentage of blood remaining in the LA for longer than one cycle after CA (65.9% vs 43.3% in patient A and 62.2% vs 54.8% in patient B). Maximum temperatures of 76 C and 58 C were observed when CA was performed near the appendage and in a pulmonary vein, respectively.CONCLUSION: This computational study presents novel models to elucidate relations between catheter temperature, patient-specific atrial anatomy and blood velocity, and predict how they change from SR to AF. The models can quantify blood flow in critical regions, including residence times and temperature distribution for different catheter positions, providing a basis for quantifying stroke risks.
- Published
- 2018
70. Wake dynamics and heuristic modelling in the desynchronization region of 1-DOF VIV
- Author
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Chris Morton, Christopher Mark O'Neill, and Graham Riches
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Fluid Flow and Transfer Processes ,Physics ,Oscillation ,Mechanical Engineering ,Phase (waves) ,Natural frequency ,02 engineering and technology ,Mechanics ,Wake ,Condensed Matter Physics ,Vortex shedding ,01 natural sciences ,010305 fluids & plasmas ,Physics::Fluid Dynamics ,020303 mechanical engineering & transports ,Amplitude ,0203 mechanical engineering ,0103 physical sciences ,Cylinder ,Wake turbulence - Abstract
Vortex-induced vibrations of a circular cylinder has been investigated experimentally using a cyber-physical apparatus with m ∗ = 8 and ζ = 0.005 . The Reynolds number is held fixed at Re = 4000 , with the reduced velocity being modified via a change in the structural natural frequency in a cyber-physical controller. The study focus is on a detailed analysis of the wake dynamics in the desynchronization region of VIV, where the cylinder motion is no longer synchronized to the wake vortex shedding. The analysis is presented using Proper Orthogonal Decomposition (POD), Phase Averaging, and a novel technique that improves the POD approach by shifting the reference frame of the velocity field data. Each analysis approach is targeted towards efficiently extracting the coherent motions from the wake flow and developing a heuristic model that empirically links the dynamically relevant modes. The results demonstrate that coherent motions persist in the desynchronization region and involve the interaction of two frequencies: the vortex shedding frequency, f VS and the lock-in oscillation frequency of the cylinder, f o . The interaction between these two frequencies produces changes in the fluctuating field dynamics that are centered on the beat frequency, f VS - f o . When the vortex shedding frequency and oscillation frequency are in phase, the cylinder exhibits a strong dynamic response. As they move out of phase, the cylinder response decays. These dynamics of the wake are captured in the first six POD modes. Moreover, the amplitude of these modes is shown to be linked to POD modes representing low frequency variations in the base flow with time.
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- 2021
71. God - A Christmas Visit
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Mark O'Neill and Mark O'Neill
- Abstract
What if God decided to celebrate his son's birthday on earth? God – A Christmas Visit is an entertaining fantasy that deals with the positive aspects of the human psyche in a fun and light-hearted way, a story of loss, hope and redemption.
- Published
- 2020
72. La Spia Rinnegata
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Mark O'Neill and Mark O'Neill
- Abstract
Il Capitano Sophie Decker, del Servizio Segreto Tedesco, è nota perché non le piace giocare seguendo le regole. Questo le ha procurato molti nemici, specie nell'organizzazione dove lavora. Ma quando un informatore svela un complotto per uccidere la Cancelliera Tedesca, a Decker viene affidato l'incarico di proteggere la Cancelliera e far fuori l'assassino. Sembra quella giusta per il lavoro, una che farà qualsiasi cosa per completare la propria missione. Ma la Decker non si è mai trovata a fronteggiare un avversario come Lo Scorpione. E'inarrestabile e senza scrupoli, un killer senza volto con una quasi prodigiosa abilità di sparire senza lasciare traccia. Sul suo cammino, solo una scia di cadaveri. Sconfiggere lo Scorpione richiederà un lavoro di squadra, precisione e usare il sistema, tutte cose che la Decker non usa di solito. Ma questa volta, l'atteggiamento ribelle della Decker potrebbe costare la vita della Cancelliera.
- Published
- 2020
73. L’oro della Reichsbank : Il passato non è ancora finito
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Mark O'Neill and Mark O'Neill
- Abstract
Quando la Germania è sotto attacco, l'unica risposta è la morte. Febbraio 1945 : Con la fine della guerra ormai vicina, il regime Nazista sposta tutti i propri soldi e le riserve della Reichsbank, da Berlino alle miniere di sale di Merkers. Ma un po'di quell'oro viene rubato e non verrà mai più ritrovato. Settembre 2017 : Una campagna elettorale nazionale piena di colpi bassi si svolge in Germania. Nazionalisti di estrema destra, collegati ad uno dei candidati di punta, terrorizzano le strade ammazzando a volontà. La Decker riceve l'ordine dalla Cancelliera Tedesca di mettere fine alla violenza. Ma non sanno che l'oro scomparso della Reichsbank ed una icona Nazista che si credeva perduta, avrebbero reso Berlino una polveriera pronta ad esplodere.
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- 2020
74. Connecting Museums
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Mark O'Neill, Glenn Hooper, Mark O'Neill, and Glenn Hooper
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- Museums--Social aspects, Museums and community, Museums--Management
- Abstract
Connecting Museums explores the boundaries of museums and how external relationships are affected by internal commitments, structures and traditions. Focusing on museums'relationship with heath, inclusion, and community, the book provides a detailed assessment of the alliances between museums and other stakeholders in recent years.With contributions from practitioners and established and early-career academics, this volume explore the ideas and practices through which museums are seeking to move beyond what might be called one-off contributions to society, to reach places where the museum is dynamic and facilitates self-generation and renewal, where it can become not just a provider of a cultural service, but an active participant in the rehabilitation of social trust and democratic participation. The contributors to this volume provide conceptual critiques and clarification of a number of key ideas which form the basis of the ethics of museum legitimacy, as well as a number of reports from the front line about the experience of trying to renew museums as more valuable and more relevant institutions.Providing internal and external perspectives, Connecting Museums presents a mix of applied and theoretical understandings of the changing roles of museums today. As such, the book should be of interest to academics, researchers and students working in the broad fields of museum and heritage studies, material culture, and arts and museum management.
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- 2020
75. Museums and their Paradoxes
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Mark O'Neill
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Value (ethics) ,060101 anthropology ,media_common.quotation_subject ,05 social sciences ,Perspective (graphical) ,General Engineering ,06 humanities and the arts ,Aesthetics ,0502 economics and business ,0601 history and archaeology ,Sociology ,Function (engineering) ,050212 sport, leisure & tourism ,media_common - Abstract
This chapter is written from the perspective of a practitioner and explores a range of paradoxes in museums and in the museological literature which may serve as starting points for conversations with philosophers. These include questions of definition and mission, intrinsic versus instrumental value, whether museums actively shape society or serve as a passive reflection, whether their main function is to produce liberating knowledge or express communal identities, whether traditional or progressive museums are the most ‘traditional’, whether museums are trying to serve idealized or real visitors and, ultimately, whether museums are rational or ritual institutions.
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- 2016
76. ORAL AB AGORA1362Cardiac Involvement in Patients With Different Rheumatic Disorders1366Gender differences in the development of cardiac complications: a multicentric prospective study in a large cohort of thalassemia major patients1646Comparison of T1-mapping, T2-weighted and contrast-enhanced cine imaging at 3.0T CMR for diagnostic oedema assessment in ST-segment elevation myocardial infarction1375Evaluation of Tissue Changes in Remote Noninfarcted Myocardium after Acute Myocardial Infarction using T1-mapping1377Right ventricular long axis strain – The prognostic value of a novel parameter in non-ischemic dilated cardiomyopathy using standard cardiac magnetic resonance imaging1389The role of the right ventricular insertion point in heart failure patients with preserved ejection fraction: Insights from a cardiovascular magnetic resonance study1398Myocardial fibrosis associates with B-type natriuretic peptide levels and outcomes more than wall stress1478Prognostic Value of Pulmonary Blood Volume by Contrast-Enhanced Magnetic Resonance Imaging in Heart Failure Outpatients – The PROVE-HF Study1370Magnetic Resonance Adenosine Perfusion Imaging as Gatekeeper of Invasive Coronary1509Influence of non-invasive hemodynamic CMR parameters on maximal exercise capacity in surgically untreated patients with Ebstein's anomaly1356Proximal aortic stiffening in Turner patients is more pronounced in the presence of a bicuspid valve. A segmental functional MRI study1503Flow pattern and vascular distensibility of the pulmonary arteries in patients after repair of tetralogy of Fallot. Insights from 4D flow CMR1516Myocardial deformation characteristics of the systemic right ventricle after atrial switch operation for transposition of the great arteries1633Three-dimensional vortex formation in patients with a Fontan circulation: evaluation with 4D flow CMR1483Mitral valve prolapse: arrhythmogenic substrates by cardiac magnetic imaging1596Increased local wall shear stress after coarctation repair is associated with descending aorta pulse wave velocity: evaluation with CMR and 4D flow1636Three-dimensional wall shear stress assessed by 4Dflow CMR in bicuspid aortic valve disease1464Cardiac Amyloidosis and Aortic Stenosis – The Convergence of Two Aging Processes1630Blood T1 variability explained in healthy volunteers: an analysis on MOLLI, ShMOLLI and SASHA1408Myocardial deformation on CMR predicts adverse outcomes in carcinoid heart disease - a new marker of risk1492Myocardial Perfusion Reserve and Global Longitudinal Strain in Early Rheumatoid Arthritis1500Exercise CMR to differentiate athlete's heart from patients with early dilated cardiomyopathy1559Real-Time, x-mri guidance to optimise left ventricular lead placement for delivery of cardiac resynchronisation therapy1560The role of Cardiac magnetic resonance imaging in patients undergoing ablation for ventricular tachycardia- Defining the substrate and visualizing the outcome1590Impact of cardiovascular magnetic resonance on clinical management and decision-making of out of hospital cardiac arrest survivors with inconclusive coronary angiogram1561Detection of coronary stenosis at rest using Oxygenation-Sensitive Magnetic Resonance Imaging
- Author
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J. Ranjit Arnold, A. Baritussio, S. Oebel, Jonathan Behar, G. Claessen, G.J. Fent, B. Liu, Stefania Rosmini, João L. Cavalcante, Lydia Dux-Santoy, I. Nederend, Manuel De Lazzari, Vivian P. Kamphuis, B.E.U. Burkhardt, Beate Ruecker, Daniel G.H. Devos, Christian Meierhofer, Peter Bernhardt, F. Ricci, Aatif Sayeed, Andreas A. Kammerlander, Nisha Arenja, P. Stefan Biesbroek, Sheraz A. Nazir, A. Meloni, S. Greulich, D. Kitterer, J. Latus, J. Henes, R. Kurmann, S. Gloekler, A. Wahl, S. Buss, H. Katus, M. Bobbo, M. Lombardi, N. Braun, M.D. Alscher, U. Sechtem, H. Mahrholdt, M.G. Neri, P. Preziosi, E. Grassedonio, N. Schicchi, P. Keilberg, S. Pulini, E. Facchini, V. Positano, A. Pepe, Abhishek Shetye, Jamal N. Khan, Anvesha Singh, Prathap Kanagala, Daniel Swarbrick, Gaurav Gulsin, Matthew Graham-Brown, Iain Squire, Anthony Gershlick, Gerry P. McCann, Raquel P. Amier, Paul F.A. Teunissen, Lourens F.H.J. Robbers, Aernout M. Beek, Albert C. van Rossum, Mark B.M. Hofman, Niels van Royen, Robin Nijveldt, Johannes H Riffel, Charly Noel Djiokou, Florian Andre, Thomas Fritz, Manuel Halder, Zelniker Thomas, Grigorios Korosoglou, Hugo A Katus, Sebastian J Buss, Marianne L. Schwaiger, Franz Duca, Stefan Aschauer, Beatrice A. Marzluf, Caroline Zotter-Tufaro, Daniel Dalos, Stefan Pfaffenberger, Diana Bonderman, Julia Mascherbauer, Yaron Fridman, Brianne Hackman, Ajay Kadakkal, Maren Maanja, Hussein Abu Daya, Timothy C. Wong, Erik B. Schelbert, A. Barison, G. Todiere, R. Gaeta, S. Galllina, M. Emdin, R. De Caterina, G.D. Aquaro, Dominik Buckert, Nils Dyckmanns, Wolfgang Rottbauer, Andreas Kühn, Nerejda Shehu, Jan Müller, Heiko Stern, Peter Ewert, Sohrab Fratz, Manfred Vogt, Katya De Groote, Danilo Babin, Laurent Demulier, Yves Taeymans, Jos J. Westenberg, Luc Van Bortel, Patrick Segers, Eric Achten, Jean De Schepper, Ernst Rietzschel, Julia Geiger, Malek Makki, Barbara Burkhardt, Christian J. Kellenberger, Emanuela R. Valsangiacomo Buechel, C.J. Kellenberger, J. Geiger, B. Ruecker, E.R. Valsangiacomo Buechel, Mohammed S.M. Elbaz, Lucia J.M. Kroft, Rob J. van der Geest, Albert de Roos, Nico A. Blom, Jos J.M. Westenberg, Arno A.W. Roest, Alberto Cipriani, Angela Susana, Stefania Rizzo, Benedetta Giorgi, Lacognata Carmelo, Emanuele Bertaglia, Barbara Bauce, Domenico Corrado, Gaetano Thiene, Martina Perazzolo Marra, Cristina Basso, Sabino Iliceto, A.A.W. Roest, P.J. van den Boogaard, A.D.J. ten Harkel, J.C.N. de Geus, L.J.M. Kroft, A. de Roos, J.J.M. Westenberg, Raquel Kale, Gisela Teixido-Tura, Giuliana Maldonado, Marina Huguet, David Garcia-Dorado, Artur Evangelista, Jose Rodriguez-Palomares, Shasank Rijal, John T. Schindler, Thomas G. Gleason, Joon S. Lee, Heerajnarain Bulluck, Thomas A Treibel, Anish Bhuva, Amna Abdel-Gadir, Veronica Culotta, Ahmed Merghani, Viviana Maestrini, Anna S Herrey, Peter Kellman, Charlotte Manisty, James C Moon, M.K. Hayer, S. Baig, T. Shah, S.J. Rooney, N.C. Edwards, R.P. Steeds, P. Garg, P. Swoboda, L.E. Dobson, T.A. Musa, J.F. Foley, P. Haaf, J.P. Greenwood, S. Plein, F. Schnell, J. Bogaert, S. Dymarkowski, N. Pattyn, P. Claus, J. Van Cleemput, A. La Gerche, H. Heidbuchel, Daniel Toth, Sabrina Reiml, Maria Panayiotou, Simon Claridge, Tom Jackson, Manav Sohal, Jessica Webb, Mark O'Neill, Alexander Brost, Peter Mountney, Reza Razavi, Kawal Rhode, Christopher Aldo Rinaldi, A. Arya, S. Hilbert, A. Bollmann, G. Hindricks, C. Jahnke, I. Paetsch, B. Dinov, M. Perazzolo Marra, A. Ghosh Dastidar, J. Rodrigues, A. Zorzi, A. Susana, A. Scatteia, E. De Garate, G. Mattesi, J. Strange, D. Corrado, C. Bucciarelli-Ducci, Michael Jerosch-Herold, Theodoros D. Karamitsos, Jane M. Francis, Paul Bhamra-Ariza, Rizwan Sarwar, Robin Choudhury, Joseph B. Selvanayagam, and Stefan Neubauer
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medicine.medical_specialty ,business.industry ,Bicuspid valve ,Internal medicine ,Cardiology ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Cardiology and Cardiovascular Medicine ,business ,Stiffening - Published
- 2016
77. That’s all very well in practice, but what about the theory?
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Mark O'Neill and Robert Rogerson
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Politics ,Battle ,Austerity ,media_common.quotation_subject ,Political science ,Financial crisis ,Social change ,Public administration ,Thatcherism ,The arts ,media_common ,Social policy - Abstract
Pressure on UK local authority managed or funded cultural services has become a given at least since the Thatcherite rejection in the 1980s of the post-war consensus. While there was significant investment under New Labour, this was tied to economic and social policy in ways that reflected a continuation of underlying neoliberal principles (Hesmondhalgh et al, 2015a, b). Heightened by the global financial crisis of 2008, the current regime of austerity has created a continuous battle to retain and manage diminishing cultural services and grants to independent cultural organisations. In response, the cultural sector has over the past few decades become more aligned with wider economic and social development agendas (Gray, 2007; 2017, Throsby, 2010) and consequently has had to adapt organisational structures and approaches in order to reposition arts and culture. Kent Council’s recent transfer of culture into the economic development department, and the construction of narratives of its operations as “delivering economic growth, skills development and community wellbeing” (Witton, 2015) is a familiar move, replicated across the UK and internationally (Knell and Taylor, 2011; Grodach and Seman, 2013; Overmans and Noordegraf, 2014). In this context the experience of Glasgow City Council’s organisational change in how it supported arts, culture and sport is viewed as one of success, particularly in helping the city redefine its image enhancing its economic wellbeing and developing its cultural infrastructure. This case study focuses on Culture and Sport Glasgow (CSG) – branded now as Glasgow Life – which is the result of a series of major organisational shifts over the past 30 years and is widely seen as effective in supporting the wider strategy of urban redevelopment undertaken since the 1980s. Glasgow Life has avoided the need for large-scale closures of services such as libraries and museums and has been able to maintain or increase capital investment in new and refurbished facilities, despite the City being under financial pressures similar to those experienced by most UK local authorities. This case study explores how such success has been achieved and asks whether in adapting to the fiscal and political environment council services have faced, the Glasgow Life experience offers wider learning and insights – both to large scale civic services and to the cultural sector in general.
- Published
- 2018
78. The effects of supercritical fluids on amorphous polymers
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Mark O'Neill
- Published
- 2018
79. Pit Crew Approach to Pre Hospital Trauma Resuscitation
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Ray Quinn, Angela Sheridan, Danny Dowdall, David Menzies, Phil Darcy, Mark O'Neill, and Mark O'Byrne
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lcsh:R5-920 ,Resuscitation ,business.industry ,Major trauma ,education ,Crew ,Psychological intervention ,medicine.disease ,Trauma care ,Multidisciplinary team ,Trauma ,medicine ,Medical team ,Medical emergency ,lcsh:Medicine (General) ,Trauma resuscitation ,business ,Pit Crew ,Team - Abstract
IntroductionPre hospital trauma care is often delivered by dual crewed ambulances supported by additional resources as necessary and available. Coordinating resuscitation of a critically injured patient may require multiple simultaneous actions. Equally, a large number of practitioners can hinder patient care if not coordinated.AimsTo describe a multi disciplinary, scaleabe approach to pre hospital trauma care suitable for small and large multi disciplinary teams. Methods The MCI medical team (as part of Motorsport Rescue Services) is a PHECC-registered multidisciplinary team, which provides medical cover at Motorcycle road racing events in Ireland. The MCI medical team has significant experience of major trauma and routinely performs prehospital anaesthesia for trauma patients. We have evolved a pit crew approach to trauma care with pre defined roles and interventions assigned to a five person team, three clinical members, a scribe and a team lead. The approach is both scalable and collapsible, meaning that if multiple patients are present, roles can be merged; if additional clinical input is required, roles can also be supplemented. Each team member carries equipment and medications specific to their role, allowing efficiencies at the patients side.ResultsThe pit crew approach to pre hospital trauma care has evolved over a decade and is routinely implemented at motorcycle road races in Ireland.ConclusionsThe pit crew trauma approach, although applicable to a pre defined five person team in unique circumstances, may also be applicable to ad hoc clinical teams that typically form in the pre hospital arena.
- Published
- 2018
80. 'A Completely New Approach' to Indigenous Cultural Heritage: Evaluating the Queensland Aboriginal Cultural Heritage Act
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Mark O'Neill
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Cultural Studies ,Hegemony ,060102 archaeology ,Sociology and Political Science ,State control ,Field (Bourdieu) ,05 social sciences ,0507 social and economic geography ,lcsh:Political science ,Environmental ethics ,06 humanities and the arts ,Indigenous ,Variety (cybernetics) ,lcsh:Social Sciences ,lcsh:H ,Cultural heritage ,Anthropology ,Political science ,0601 history and archaeology ,050703 geography ,lcsh:J - Abstract
The Aboriginal Cultural Heritage Act 2003 challenged the hegemony that Western, archaeological methodologies has held over Indigenous cultural heritage in Australia. By choosing to relinquish state control and authority over cultural heritage in favour of the expertise of Indigenous people, the Act created a unique and innovative heritage policy. Over the 10 years the Act has been in force, it has seen a variety of approaches adopted as part of myriad projects. This has created a mature field of practice for investigation and analysis. This article examines and critiques the Act to determine its successes and weaknesses. In doing so, it offers opportunities for other policy-makers to consider as part of policy review.
- Published
- 2018
81. Cardiac MR Characterization of left ventricular remodeling in a swine model of infarct followed by reperfusion
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John, Whitaker, Cory M, Tschabrunn, Jihye, Jang, Eran, Leshem, Mark, O'Neill, Warren J, Manning, Elad, Anter, and Reza, Nezafat
- Abstract
Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias.We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia-reperfusion-mediated MI.Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia-reperfusion experimental model of MI.1.5T Philips Achieva scanner. Serial cardiac MRI was performed at 16, 33, and 62 days post-MI, including cine imaging, native and postcontrast TRegions of interest were selected on the parametric maps to assess native TParameters estimated at more than two timepoints were compared with a one-way repeated measures analysis of variance. Parametric mapping data were analyzed using a generalized linear mixed model corrected for multiple observations. A result was considered statistically significant at P 0.05.All animals developed anteroseptal akinesia and hyperenhancement on DB-LGE with a central core of nonenhancing tissue. Mean hyperenhancement volume did not change during the observation period, while the central core contracted from 2.2 ± 1.8 ml at 16 days to 0.08 ± 0.19 ml at 62 days (P = 0.008). Native TIn this swine model of MI, serial quantitative cardiac MR exams allow characterization of LV remodeling and scar formation.2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
- Published
- 2018
82. A Survey Of the Privacy Preferences and Practices of Iranian Users of Telegram
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Mark O'Neill, Daniel Zappala, Justin Wu, Reza Farahbakhsh, Kent E. Seamons, and Elham Vaziripour
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Computer science - Published
- 2018
83. Management of atrial fibrillation and anticoagulant therapies
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Mark O’Neill, John Whitaker, Jonathan Birns, and Matthew Wright
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cardiovascular diseases - Abstract
Atrial fibrillation (AF) is a common supraventricular arrhythmia which is commonly found in older adults. It is associated with an increased risk of stroke and has a detrimental effect on quality of life. Management of AF involves an attempt to reduce the increased risk of stroke and to treat the symptoms that result from a high (or low) ventricular rate as well as, in some cases, the atrial rhythm itself. The management of AF involves a comprehensive assessment of a patient’s individual stroke and bleeding risk and a careful documentation of the impact of their symptoms on quality of life. Treatment options range from conservative to highly invasive. Selecting the appropriate combination from the range of options necessitates an understanding of the risks and benefits of each, so that the patient and physician can jointly identify the most appropriate management strategy.
- Published
- 2017
84. Measure What Can Be Measured: Multimodal Examination of the Atrial Fibrillation Substrate
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Mark, O'Neill and Steven E, Williams
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Magnetic Resonance Spectroscopy ,Atrial Fibrillation ,Catheter Ablation ,Humans ,Heart Atria ,Electrodes ,Article - Published
- 2017
85. A work flow to build and validate patient specific left atrium electrophysiology models from catheter measurements
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Cesare, Corrado, Steven, Williams, Rashed, Karim, Gernot, Plank, Mark, O'Neill, and Steven, Niederer
- Subjects
Epicardial Mapping ,Cardiac Catheterization ,Cardiac Pacing, Artificial ,Models, Cardiovascular ,Biophysical modelling ,macromolecular substances ,Patient specific ,Article ,Workflow ,Electrocardiography ,Heart Conduction System ,Atrial Fibrillation ,Atria ,Validation ,cardiovascular system ,Humans ,cardiovascular diseases ,Heart Atria ,Algorithms - Abstract
Highlights • Locally personalised atrial electrophysiology. • Predictive simulations. • Catheter measurements. • Clinical time scale. • Atrial fibrillation., Graphical abstract, Biophysical models of the atrium provide a physically constrained framework for describing the current state of an atrium and allow predictions of how that atrium will respond to therapy. We propose a work flow to simulate patient specific electrophysiological heterogeneity from clinical data and validate the resulting biophysical models. In 7 patients, we recorded the atrial anatomy with an electroanatomical mapping system (St Jude Velocity); we then applied an S1–S2 electrical stimulation protocol from the coronary sinus (CS) and the high right atrium (HRA) whilst recording the activation patterns using a PentaRay catheter with 10 bipolar electrodes at 12 ± 2 sites across the atrium. Using only the activation times measured with a PentaRay catheter and caused by a stimulus applied in the CS with a remote catheter we fitted the four parameters for a modified Mitchell–Schaeffer model and the tissue conductivity to the recorded local conduction velocity restitution curve and estimated local effective refractory period. Model parameters were then interpolated across each atrium. The fitted model recapitulated the S1–S2 activation times for CS pacing giving a correlation ranging between 0.81 and 0.98. The model was validated by comparing simulated activations times with the independently recorded HRA pacing S1–S2 activation times, giving a correlation ranging between 0.65 and 0.96. The resulting work flow provides the first validated cohort of models that capture clinically measured patient specific electrophysiological heterogeneity.
- Published
- 2017
86. Epicardial electroanatomical mapping, radiofrequency ablation, and lesion imaging in the porcine left ventricle under real-time magnetic resonance imaging guidance-an in vivo feasibility study
- Author
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Rahul K, Mukherjee, Sébastien, Roujol, Henry, Chubb, James, Harrison, Steven, Williams, John, Whitaker, Louisa, O'Neill, John, Silberbauer, Radhouene, Neji, Rainer, Schneider, Thomas, Pohl, Tom, Lloyd, Mark, O'Neill, and Reza, Razavi
- Subjects
Gadolinium DTPA ,Time Factors ,Heart Ventricles ,Sus scrofa ,Action Potentials ,Contrast Media ,Magnetic Resonance Imaging, Interventional ,Cardiac Catheters ,Heart Rate ,Predictive Value of Tests ,Models, Animal ,Catheter Ablation ,Animals ,Feasibility Studies ,Female ,Electrophysiologic Techniques, Cardiac - Abstract
Magnetic resonance imaging (MRI) is the gold standard for defining myocardial substrate in 3D and can be used to guide ventricular tachycardia ablation. We describe the feasibility of using a prototype magnetic resonance-guided electrophysiology (MR-EP) system in a pre-clinical model to perform real-time MRI-guided epicardial mapping, ablation, and lesion imaging with active catheter tracking.Experiments were performed in vivo in pigs (n = 6) using an MR-EP guidance system research prototype (Siemens Healthcare) with an irrigated ablation catheter (Vision-MR, Imricor) and a dedicated electrophysiology recording system (Advantage-MR, Imricor). Following epicardial access, local activation and voltage maps were acquired, and targeted radiofrequency (RF) ablation lesions were delivered. Ablation lesions were visualized in real time during RF delivery using MR-thermometry and dosimetry. Hyper-acute and acute assessment of ablation lesions was also performed using native T1 mapping and late-gadolinium enhancement (LGE), respectively. High-quality epicardial bipolar electrograms were recorded with a signal-to-noise ratio of greater than 10:1 for a signal of 1.5 mV. During epicardial ablation, localized temperature elevation could be visualized with a maximum temperature rise of 35 °C within 2 mm of the catheter tip relative to remote myocardium. Decreased native T1 times were observed (882 ± 107 ms) in the lesion core 3-5 min after lesion delivery and relative location of lesions matched well to LGE. There was a good correlation between ablation lesion site on the iCMR platform and autopsy.The MR-EP system was able to successfully acquire epicardial voltage and activation maps in swine, deliver, and visualize ablation lesions, demonstrating feasibility for intraprocedural guidance and real-time assessment of ablation injury.
- Published
- 2017
87. Intrusion Detection with Unsupervised Heterogeneous Ensembles Using Cluster-Based Normalization
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Scott Heidbrink, Mark O'Neill, Yung Ryn Choe, Eric Gustafson, and Scott Ruoti
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Normalization (statistics) ,Computer science ,business.industry ,020208 electrical & electronic engineering ,02 engineering and technology ,Intrusion detection system ,computer.software_genre ,Machine learning ,ComputingMethodologies_PATTERNRECOGNITION ,0202 electrical engineering, electronic engineering, information engineering ,Anomaly detection ,Algorithm design ,Network intrusion detection ,Artificial intelligence ,Data mining ,Web service ,Cluster analysis ,business ,computer ,Cluster based - Abstract
Outlier detection has been shown to be a promising machine learning technique for a diverse array of felds and problem areas. However, traditional, supervised outlier detection is not well suited for problems such as network intrusion detection, where proper labelled data is scarce. This has created a focus on extending these approaches to be unsupervised, removing the need for explicit labels, but at a cost of poorer performance compared to their supervised counterparts. Recent work has explored ways of making up for this, such as creating ensembles of diverse models, or even diverse learning algorithms, to jointly classify data. While using unsupervised, heterogeneous ensembles of learning algorithms has been proposed as a viable next step for research, the implications of how these ensembles are built and used has not been explored.
- Published
- 2017
88. Condensing Steam
- Author
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Daniel Zappala, Mark O'Neill, Elham Vaziripour, and Justin Wu
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Engineering ,business.industry ,05 social sciences ,Internet privacy ,050801 communication & media studies ,020206 networking & telecommunications ,02 engineering and technology ,Popularity ,World Wide Web ,0508 media and communications ,Measurement study ,0202 electrical engineering, electronic engineering, information engineering ,Snapshot (computer storage) ,business - Abstract
We present a comprehensive measurement study of the Steam gaming network, the first complete examination of any major gaming network, comprising all 108.7 million user accounts and 384.3 million owned games. We examine gamer behavior across the dimensions of social connectivity, playtime, game ownership, genre affinity, and monetary expenditure. As a whole, gamer behavior is highly diverse and characterized by heavy-tailed distributions. Most players exhibit modest behaviors in terms of the number of minutes played per day and the amount of money spent on games, though there is a long tail withoutliers, such as gamers who maximize achievements or playtime stats, or gamers who collect games they don't play. We find some strong correlations that show that players tend to befriend those who are similar in terms of popularity, playtime, money spent, and games owned. We collect a second snapshot of the Steam network and show that our findings are robust across both measurements. We conclude by relating these findings to other relevant studies, including gamer stereotypes, game addiction, and social networking.
- Published
- 2016
89. TLS Proxies
- Author
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Mark O'Neill, Kent E. Seamons, Scott Ruoti, and Daniel Zappala
- Subjects
Computer science ,business.industry ,Internet privacy ,020206 networking & telecommunications ,02 engineering and technology ,User awareness ,Man-in-the-middle attack ,computer.software_genre ,Computer security ,Certificate ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Malware ,business ,computer - Abstract
We measure the prevalence and uses of TLS proxies using a Flash tool deployed with a Google AdWords campaign. We generate 2.9 million certificate tests and find that 1 in 250 TLS connections are TLS-proxied. The majority of these proxies appear to be benevolent, however we identify over 1,000 cases where three malware products are using this technology nefariously. We also find numerous instances of negligent, duplicitous, and suspicious behavior, some of which degrade security for users without their knowledge. Distinguishing these types of practices is challenging in practice, indicating a need for transparency and user awareness.
- Published
- 2016
90. Mechanistic Understanding of the Planarization Behavior of Low κ Organosilicate Glass Films with Beol Barrier Slurries
- Author
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Anupama Mallikarjunan, Jennifer Achtyl, Rung-Je Yang, Chen-Yuan Huang, Shih-Hsuan Chao, Lu Gan, Robert Ridgeway, James Schlueter, Ming-Shih Tsai, Chris Li, and Mark O'Neill
- Abstract
Low κ Organosilicate Glass (OSG) films are being proliferated into new IC device architectures with CMP requirements spanning a wide range (highly selective to non-selective, low polish rates to high polish rates). This study aims to understand the relationship between these OSG film properties (both bulk and surface) and their planarization response, especially removal rate (RR). Eight OSG films were polished along with TEOS oxide using two barrier slurries. The films ranged in carbon content from 8 to 24 % and in nanoindentation elastic modulus from 5.5 to 21.8 GPa. Counterintuitively, higher mechanical strength (i.e., hardness, elastic modulus) of the low κ film did not result in lower polish rates; but was in agreement with previously noted behavior [1]. Removal rates also did not correlate to key OSG film properties such as refractive index (RI), dielectric constant (κ), or total carbon content (by X-ray photoelectron spectroscopy). However, an inverse relationship was observed between RR and the bulk chemical bonding structure (Si-CH3/Si-O ratio) as determined by transmission infrared spectroscopy (FT-IR) measurements (see Figure 1). In addition, a correlation between RR and OSG film’s surface free energy post-polish (measured from water and diiodomethane contact angles) was also observed. Based on the above findings, a mechanistic understanding of low κ OSG polishing was developed. [1] L. Matz, M. Haas, M. O’Neill, R. Sawayda, A. Meyers, in Advanced Metallization Conference (AMC) (eds A. J. McKerrow, Y. Shacham-Diamand, S. Shingubara and Y. Shimogaki), Materials Research Society, Warrandale, PA, 463 (2009) Figure 1
- Published
- 2019
91. Muzeji. Zdravlje i blagostanje: oslanjanje na tradiciju u cilju povećanja učinka muzeja
- Author
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Mark O'Neill and Mark O'Neill
- Abstract
Obrazlažući poveznicu između muzeja i zdravlja stanovništva, autor se oslanja na dva argumenta: prvo, da je pojava javnih muzeja u 19. stoljeću bila dijelom pokreta širokih razmjera usmjerenoga na poboljšanje javnoga zdravlja i blagostanja te drugo, da postoje značajni dokazi, prema statistikama o javnom zdravlju, prema kojima posjet muzeju doista ima stvaran učinak na zdravlje ljudi., In order to elaborate the connection between museums and public health and wellbeing, the author builds a case around two arguments: first that the emergence of public museums in the 19th century was part of a broad movement to improve public health and wellbeing; and second, that there is significant evidence from public health statistics that museum visiting does make a real difference to people’s health.
- Published
- 2017
92. Real-Time X-MRI-Guided Left Ventricular Lead Implantation for Targeted Delivery of Cardiac Resynchronization Therapy
- Author
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Jonathan M, Behar, Peter, Mountney, Daniel, Toth, Sabrina, Reiml, Maria, Panayiotou, Alexander, Brost, Bernhard, Fahn, Rashed, Karim, Simon, Claridge, Tom, Jackson, Ben, Sieniewicz, Nik, Patel, Mark, O'Neill, Reza, Razavi, Kawal, Rhode, and Christopher Aldo, Rinaldi
- Subjects
Cardiac Resynchronization Therapy ,Prosthesis Implantation ,Humans ,Magnetic Resonance Imaging, Interventional ,Magnetic Resonance Imaging ,Aged ,Defibrillators, Implantable - Abstract
This study sought to test the feasibility of a purpose-built, integrated software platform to process, analyze, and overlay cardiac magnetic resonance (CMR) data in real time within a combined cardiac catheter laboratory and magnetic resonance imaging scanner suite (X-MRI) to guide left ventricular (LV) lead implantation.Suboptimal LV lead position is a major determinant of poor cardiac resynchronization therapy (CRT) response, and the optimal site is highly patient specific. Pacing myocardial scar is associated with poorer outcomes; conversely, targeting latest mechanical activation (LMA) may improve them.Fourteen patients (age 74 ± 5.1 years; New York Heart Association functional class: 2.7 ± 0.4; 86% ischemic with ejection fraction 27 ± 7.6%; QRSd: 157 ± 19 ms) underwent CMR followed by immediate CRT implantation using derived scar and dyssynchrony data, overlaid onto fluoroscopy in an X-MRI suite. Rapid LV segmentation enabled detailed scar quantification, identification of LMA segments, and selection of myocardial targets. At coronary venography, the CMR-derived 3-dimensional shell was fused, enabling identification of viable venous targets subtended by target segments for LV lead placement.The platform was successful in all 14 patients, of whom 10 (71%) were paced in pre-procedurally defined target segments. Pacing in CMR-defined target segments (out of scar) showed a significant decrease in the LV capture threshold (mean difference: 2.4 [1.5 to 3.2]; p 0.001) and shorter paced QRS duration (mean difference: 25 [15 to 34]; p 0.001) compared with pacing in areas of CMR determined scar. In 5 (36%) patients with extensive scar in the posterolateral wall, CMR guidance enabled successful lead delivery in an alternative anatomically favorable site. Radiation dose and implant times were similar to historical controls (p = NS).Real-time CMR-guided LV lead placement is feasible and achievable in a single clinical setting and may prove helpful to preferentially select sites for LV lead placement.
- Published
- 2016
93. 'We're on the Same Page'
- Author
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Scott Heidbrink, Elham Vaziripour, Scott Ruoti, Mark O'Neill, Justin Wu, Kent E. Seamons, Daniel Zappala, and Jeff Andersen
- Subjects
FOS: Computer and information sciences ,Computer Science - Cryptography and Security ,business.industry ,Computer science ,H.1.2 ,H.5.2 ,Internet privacy ,Computer Science - Human-Computer Interaction ,Usability ,02 engineering and technology ,Human-Computer Interaction (cs.HC) ,Grassroots ,Email encryption ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,business ,Cryptography and Security (cs.CR) - Abstract
Secure email is increasingly being touted as usable by novice users, with a push for adoption based on recent concerns about government surveillance. To determine whether secure email is for grassroots adoption, we employ a laboratory user study that recruits pairs of novice to install and use several of the latest systems to exchange secure messages. We present quantitative and qualitative results from 25 pairs of novice users as they use Pwm, Tutanota, and Virtru. Participants report being more at ease with this type of study and better able to cope with mistakes since both participants are "on the same page". We find that users prefer integrated solutions over depot-based solutions, and that tutorials are important in helping first-time users. Hiding the details of how a secure email system provides security can lead to a lack of trust in the system. Participants expressed a desire to use secure email, but few wanted to use it regularly and most were unsure of when they might use it., 34th Annual ACM Conference on Human Factors in Computing Systems (CHI 2016)
- Published
- 2016
94. ‘My Place or Yours?’ Reconciling Tourist and Local Needs in the Regeneration of Glasgow through Culture and Heritage
- Author
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Mark O’Neill
- Subjects
media_common.quotation_subject ,Cultural capital ,Cultural tourism ,language.human_language ,Georgian ,Geography ,European Capital of Culture ,Economy ,Rebranding ,language ,Humanities ,Tourism ,Cultural policy ,Reputation ,media_common - Abstract
Glasgow’s reputation as a leader in culture-led urban regeneration dates from 1990, when it was European Capital of Culture. While this event successfully rebranded the city, accounts (both positive and negative) miss two key histories. First, in the Georgian and Victorian periods and even in the 1970s (when the city was at its nadir), Glasgow had a substantial tourist economy. Second, Glasgow’s rebranding as a cultural tourist destination was not just based on marketing of expensive events and new attractions targeting tourists, but was founded on substantial pre-existing assets of international quality which attracted large numbers of local people from all socio-economic groups. Glasgow’s use of cultural amenities for economic regeneration only worked because these formed part of an overall inclusive vision of civic life.
- Published
- 2016
95. Museums and mortality
- Author
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Mark O'Neill
- Subjects
Visual Arts and Performing Arts ,media_common.quotation_subject ,Religious studies ,Terror management theory ,Sociology ,Immortality ,humanities ,Visual arts ,media_common - Abstract
This article applies the idea that culture is a response to human awareness of mortality to museums through the lens of two contrasting approaches to understanding death and dying: Terror managemen...
- Published
- 2012
96. Religion and cultural policy: two museum case studies
- Author
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Mark O’Neill
- Subjects
Cultural Studies ,Sociology and Political Science ,media_common.quotation_subject ,Gender studies ,Christianity ,The arts ,Appropriation ,Modern art ,Transgender ,Homosexuality ,Sociology ,Lesbian ,Cultural policy ,media_common - Abstract
This case study compares the controversies arising from two museum displays relating to the religion in Glasgow, written from the perspective of a practitioner involved in both. One, in 1993, involved the opening of the first museum of world religions in the UK and the other, in 2009, a programme of lesbian, gay, bisexual, transgender and intersex art in Glasgow’s Gallery of Modern Art. The main continuity amongst the protesters was that museums should represent Christianity and Christian values as the majority heritage of the country and not give ‘special treatment’ to minorities. The main changes over the period were: the appropriation by Christian protestors of the language of rights, and in particular a claim to a ‘right’ not to be offended; a resentment that putatively violent minority faiths were able to enforce greater respect than Christianity; and the way the Internet enabled protestors to organise and sustain a campaign over a long period. The article concludes with reflections on the implicatio...
- Published
- 2011
97. Cultural attendance and public mental health ‐ from research to practice
- Author
-
Mark O'Neill
- Subjects
medicine.medical_specialty ,Inequality ,business.industry ,Public health ,media_common.quotation_subject ,Art therapy ,Public sector ,Public Health, Environmental and Occupational Health ,Attendance ,Public relations ,Mental health ,The arts ,Psychiatry and Mental health ,Statutory law ,Pedagogy ,medicine ,Sociology ,business ,media_common - Abstract
The research on the health benefits of intensive engagement with creative and cultural activities through art therapy and workshops led by artists is well recognised in the literature on cultural impact. In general, this engagement involves small numbers and, in the current climate, is unlikely to receive sufficient investment to make a difference at a population level. Less recognised is an emerging field of epidemiological research on the health impact of ‘general cultural attendance’. This provides evidence that simply going to a museum, art gallery, film or concert on a regular basis increases longevity, and that culture is a separate variable. This article summarises this evidence and looks at the strategic implications for cultural organisations from the perspective of a practitioner. If cultural attendance can help address health inequalities, and if the best way to overcome the psychological and social barriers to cultural attendance is personal contact with a trusted guide, the article outlines a system where voluntary and statutory organisations can refer people to cultural organisations who might benefit from them. The former would need to be able to guarantee a high quality and friendly welcome that recognises the needs of first‐time users from excluded groups. Developed among a network of cultural organisations with voluntary and public sector partners, such a system could reach sufficient numbers to have a health impact on a population level.
- Published
- 2010
98. Sport, Film, and Australian Cultural Identity: Reading Hero to a Nation
- Author
-
Murray G. Phillips and Mark O'Neill
- Subjects
History ,Cultural identity ,Reading (process) ,media_common.quotation_subject ,HERO ,Physical Therapy, Sports Therapy and Rehabilitation ,Gender studies ,Sociology ,media_common - Published
- 2010
99. The social impact of the arts
- Author
-
Mark O'Neill
- Subjects
Cultural Studies ,Visual Arts and Performing Arts ,Communication ,Social impact ,Media studies ,Sociology ,Social engagement ,The arts - Abstract
The social impact of the arts, by Eleonora Belfiore and Oliver Bennett, Basingstoke, Palgrave, 2008, 240 pp., £45 (hardback), ISBN 978-0-230-57255-3 This short book is a great read, full of fascina...
- Published
- 2009
100. Le sens de la vie: le musée St Mungo de la religion dans la vie et dans l'art
- Author
-
Mark O'Neill
- Abstract
Le dernier en date des musees ecossais a suscite bien des controverses, il a ete l'objet de critiques ou de louanges egalement vehementes. En presentant un large panorama de quelques-unes des grandes religions du monde, le musee St Mungo veut avant tout transmettre un vibrant message en faveur de la comprehension et du respect mutuels. L'auteur, conservateur principal (pour l'histoire) des musees de Glasgow, etait a la tete de l'equipe qui a concu le nouveau musee. Avant d'entrer au service des musees de la ville de Glasgow en 1990, il etait conservateur du musee Springburn, etablissement independant repute pour etre «le premier musee communautaire authentique de Grande-Bretagne».
- Published
- 2009
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