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986 results on '"Manning, H."'

51. Supplementary Movie S1 from TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions

Author

Cohen, Allison S., primary, Li, Jun, primary, Hight, Matthew R., primary, McKinley, Eliot, primary, Fu, Allie, primary, Payne, Adria, primary, Liu, Yang, primary, Zhang, Dawei, primary, Xie, Qing, primary, Bai, Mingfeng, primary, Ayers, Gregory D., primary, Tantawy, Mohammed Noor, primary, Smith, Jarrod A., primary, Revetta, Frank, primary, Washington, M. Kay, primary, Shi, Chanjuan, primary, Merchant, Nipun, primary, and Manning, H. Charles, primary

Published
2023
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53. Supplementary Figures S1-S4 from Molecular Imaging of Therapeutic Response to Epidermal Growth Factor Receptor Blockade in Colorectal Cancer

Author

Manning, H. Charles, primary, Merchant, Nipun B., primary, Foutch, A. Coe, primary, Virostko, John M., primary, Wyatt, Shelby K., primary, Shah, Chirayu, primary, McKinley, Eliot T., primary, Xie, Jingping, primary, Mutic, Nathan J., primary, Washington, M. Kay, primary, LaFleur, Bonnie, primary, Tantawy, Mohammed Noor, primary, Peterson, Todd E., primary, Ansari, M. Sib, primary, Baldwin, Ronald M., primary, Rothenberg, Mace L., primary, Bornhop, Darryl J., primary, Gore, John C., primary, and Coffey, Robert J., primary

Published
2023
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55. Supplementary Data from Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells

Author

Miller, Todd W., primary, Forbes, James T., primary, Shah, Chirayu, primary, Wyatt, Shelby K., primary, Manning, H. Charles, primary, Olivares, Maria G., primary, Sanchez, Violeta, primary, Dugger, Teresa C., primary, de Matos Granja, Nara, primary, Narasanna, Archana, primary, Cook, Rebecca S., primary, Kennedy, J. Phillip, primary, Lindsley, Craig W., primary, and Arteaga, Carlos L., primary

Published
2023
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56. Supplementary Figure 1 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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57. Data from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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60. Supplementary Figure 4 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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61. Supplementary Figure 3 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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63. Supplementary Figure 9 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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64. Supplementary Figure 6 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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65. Supplementary Figure 5 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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66. Supplementary Figure 7 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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67. Supplementary Methods, Figure Legends 1-13, Table 1 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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68. Supplementary Figure 8 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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69. Supplementary Figure 2 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Author

Fox, Emily M., primary, Miller, Todd W., primary, Balko, Justin M., primary, Kuba, Maria G., primary, Sánchez, Violeta, primary, Smith, R. Adam, primary, Liu, Shuying, primary, González-Angulo, Ana María, primary, Mills, Gordon B., primary, Ye, Fei, primary, Shyr, Yu, primary, Manning, H. Charles, primary, Buck, Elizabeth, primary, and Arteaga, Carlos L., primary

Published
2023
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71. Acetate Dependence of Tumors

Author

Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., and Tu, Benjamin P.

Published
2014
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78. Simplified and highly-reliable automated production of [18F]FSPG for clinical studies.

Author

Lin, Mai, Ta, Robert T., and Manning, H. Charles

Subjects
LUNGS, RADIOCHEMICAL purification, NON-small-cell lung carcinoma, POSITRON emission tomography
Abstract

Background: (S)-4-(3-18F-Fluoropropyl)-L-Glutamic Acid ([18F]FSPG) is a positron emission tomography (PET) tracer that specifically targets the cystine/glutamate antiporter (xc−), which is frequently overexpressed in cancer and several neurological disorders. Pilot studies examining the dosimetry and biodistribution of [18F]FSPG in healthy volunteers and tumor detection in patients with non-small cell lung cancer, hepatocellular carcinoma, and brain tumors showed promising results. In particular, low background uptake in the brain, lung, liver, and bowel was observed that further leads to excellent imaging contrasts of [18F]FSPG PET. However, reliable production-scale cGMP-compliant automated procedures for [18F]FSPG production are still lacking to further increase the utility and clinical adoption of this radiotracer. Herein, we report the optimized automated approaches to produce [18F]FSPG through two commercially available radiosynthesizers capable of supporting centralized and large-scale production for clinical use. Results: Starting with activity levels of 60–85 GBq, the fully-automated process to produce [18F]FSPG took less than 45 min with average radiochemical yields of 22.56 ± 0.97% and 30.82 ± 1.60% (non-decay corrected) using TRACERlab™ FXFN and FASTlab™, respectively. The radiochemical purities were > 95% and the formulated [18F]FSPG solution was determined to be sterile and colorless with the pH of 6.5–7.5. No radiolysis of the product was observed up to 8 h after final batch formulation. Conclusions: In summary, cGMP-compliant radiosyntheses and quality control of [18F]FSPG have been established on two commercially available synthesizers leveraging high activity concentration and radiochemical purity. While the clinical trials using [18F]FSPG PET are currently underway, the automated approaches reported herein will accelerate the clinical adoption of this radiotracer and warrant centralized and large-scale production of [18F]FSPG. [ABSTRACT FROM AUTHOR]

Published
2023
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82. The Craft of Reference: The Welsh Language and the Division of Labor in Nineteenth Century Slate Quarries.

Author

Manning, H. Paul

Abstract

Discusses ideologies of language and the division of labor in nineteenth century Wales, where the slate quarries drew their labor exclusively from monoglot Welsh populations. The division between labor and capital in these quarries correlated to a virtually categorical linguistic opposition between Welsh quarriers and English owners, with the question of proper linguistic and ethnic identity of managers hotly debated on during the period. (Author/VWL)

Published
2001

85. Cost and Planning Factors in Engineering Education - A Report to the Administrative Unit of the Southeastern Section of ASEE.

Author

Manning, H. L. and Carson, R. G.

Abstract

This report covers a detailed tabulation of costs and related factors for the years 1971-72, and is divided into two groups. One group of nine has been reporting this data for 5 consecutive years and represents a fairly good cross-section sample of the schools of the area. The other group of ten have reported data for 1 to 4 years. The group of nine's data was analyzed to show trends on a year-by-year basis for the 5 years of this study. Comparisons were made of student credit hours taught, fulltime equivalent students, net space, teaching faculty, total salary expenditures for teaching faculty plus teaching assistance, fulltime equivalent clerical and technician support, salary expenditures for clerical and technician support, operating expenditures, and equipment expenditures. The data was analyzed to show relative impact in terms of use of the resources. An 8-item bibliography and appendix with definitions are included. (Author/MJM)

Published
1973

87. Feasibility of [ 18 F]FSPG PET for Early Response Assessment to Combined Blockade of EGFR and Glutamine Metabolism in Wild-Type KRAS Colorectal Cancer.

Author

Bae, Seong-Woo, Wang, Jianbo, Georgiou, Dimitra K., Wen, Xiaoxia, Cohen, Allison S., Geng, Ling, Tantawy, Mohammed Noor, and Manning, H. Charles

Subjects
GLUTAMINE, COLORECTAL cancer, EPIDERMAL growth factor receptors, MONOCLONAL antibodies, POSITRON emission tomography
Abstract

Early response assessment is critical for personalizing cancer therapy. Emerging therapeutic regimens with encouraging results in the wild-type (WT) KRAS colorectal cancer (CRC) setting include inhibitors of epidermal growth factor receptor (EGFR) and glutaminolysis. Towards predicting clinical outcome, this preclinical study evaluated non-invasive positron emission tomography (PET) with (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) in treatment-sensitive and treatment-resistant WT KRAS CRC patient-derived xenografts (PDXs). Tumor-bearing mice were imaged with [18F]FSPG PET before and one week following the initiation of treatment with either EGFR-targeted monoclonal antibody (mAb) therapy, glutaminase inhibitor therapy, or the combination. Imaging was correlated with tumor volume and histology. In PDX that responded to therapy, [18F]FSPG PET was significantly decreased from baseline at 1-week post-therapy, prior to changes in tumor volume. In contrast, [18F]FSPG PET was not decreased in non-responding PDX. These data suggest that [18F]FSPG PET may serve as an early metric of response to EGFR and glutaminase inhibition in the WT KRAS CRC setting. [ABSTRACT FROM AUTHOR]

Published
2023
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88. In Situ Measurement of Atmospheric Krypton and Xenon on Mars with Mars Science Laboratory

Author

Conrad, P. G, Malespin, C. A, Franz, H. B, Pepin, R. O, Trainer, M. G, Schwenzer, S. P, Atreya, S. K, Freissinet, C, Jones, J. H, Manning, H, Owen, T, Pavlov, A. A, Wiens, R. C, Wong, M. H, and Mahaffy, P. R

Subjects
Solar Physics, Statistics And Probability, Inorganic, Organic And Physical Chemistry, Lunar And Planetary Science And Exploration
Abstract

Mars Science Laboratorys Sample Analysis at Mars (SAM) investigation has measured all of the stable isotopes of the heavy noble gases krypton and xenon in the martian atmosphere, in situ, from the Curiosity Rover at Gale Crater, Mars. Previous knowledge of martian atmospheric krypton and xenon isotope ratios has been based upon a combination of the Viking missions krypton and xenon detections and measurements of noble gas isotope ratios in martian meteorites. However, the meteorite measurements reveal an impure mixture of atmospheric, mantle, and spallation contributions. The xenon and krypton isotopic measurements reported here include the complete set of stable isotopes, unmeasured by Viking. The new results generally agree with Mars meteorite measurements but also provide a unique opportunity to identify various non-atmospheric heavy noble gas components in the meteorites. Kr isotopic measurements define a solar-like atmospheric composition, but deviating from the solar wind pattern at 80Kr and 82Kr in a manner consistent with contributions originating from neutron capture in Br. The Xe measurements suggest an intriguing possibility that isotopes lighter than 132Xe have been enriched to varying degrees by spallation and neutron capture products degassed to the atmosphere from the regolith, and a model is constructed to explore this possibility. Such a spallation component, however, is not apparent in atmospheric Xe trapped in the glassy phases of martian meteorites.

Published
2016
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92. Collective capacitive and memristive responses in random nanowire networks: Emergence of critical connectivity pathways.

Author

O'Callaghan, C., Rocha, C. G., Niosi, F., Manning, H. G., Boland, J. J., and Ferreira, M. S.

Subjects
NANOWIRES, NONVOLATILE memory, NEUROMORPHICS, MEMRISTORS, ELECTRIC potential
Abstract

Random nanowire networks (NWNs) are promising synthetic architectures for non-volatile memory devices and hardware-based neuromorphic applications due to their history-dependent responses, recurrent connectivity, and neurosynaptic-like behaviors. Such brain-like functions occur due to emergent resistive switching phenomena taking place in the interwire junctions which are viewed as memristive systems; they operate as smart analogue switches whose resistance depends on the history of the input voltage/current. We successfully demonstrated that NWNs made with a particular class of memristive junctions can exhibit a highly-selective conduction mechanism which uses the lowest-energy connectivity path in the network identified as the "winner-takes-all" state. However, these complex networks do not always behave in the same fashion; in the limit of sufficiently low input currents (preceding this selective conduction regime), the system behaves as a leakage capacitive network and its electrical activation is driven by cascades of breakdown-based activation events involving binary capacitive transitions. Understanding these two regimes is crucial to establish the potential of these materials for neuromorphics, and for this, we present two computational modelling schemes designed to describe the capacitive and memristive responses of NWNs interrogated adiabatically by voltage/current sources. Our results are corroborated by experimental evidence that reveal the fine electrical properties of NWN materials in their respective formation (capacitive) and conducting (memristive) stages. [ABSTRACT FROM AUTHOR]

Published
2018
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94. 2801

Author

Hathaway, A. S., Archibald, R. C., and Manning, H. P.

Published
1921
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